TermID	Term	Enrichment	logP	Genes in Term	Target Genes in Term	Fraction of Targets in Term	Total Target Genes	Total Genes	Entrez Gene IDs	Gene Symbols
plk1_pathway	PLK1 signaling events	7.5115116856766e-06	-11.7990738227403	44	27	0.0415384615384615	650	2227	5058,23291,10112,4659,991,1894,701,5861,79866,995,983,79682,26271,3796,7465,2801,8555,5518,51343,5500,147841,1062,151648,9475,8945,7178,10726	PAK1,FBXW11,KIF20A,PPP1R12A,CDC20,ECT2,BUB1B,RAB1A,BORA,CDC25C,CDK1,CENPU,FBXO5,KIF2A,WEE1,GOLGA2,CDC14B,PPP2R1A,FZR1,PPP1CB,SPC24,CENPE,SGOL1,ROCK2,BTRC,TPT1,NUDC
pi3kciaktpathway	Class I PI3K signaling events mediated by Akt	1.61750078586058e-05	-11.0320432317285	34	22	0.0338461538461538	650	2227	5170,6517,2931,2475,5894,208,842,10971,1147,7531,5566,7532,572,2932,1027,7534,253260,3320,4217,7533,9882,64223	PDPK1,SLC2A4,GSK3A,MTOR,RAF1,AKT2,CASP9,YWHAQ,CHUK,YWHAE,PRKACA,YWHAG,BAD,GSK3B,CDKN1B,YWHAZ,RICTOR,HSP90AA1,MAP3K5,YWHAH,TBC1D4,MLST8
myc_activpathway	Validated targets of C-MYC transcriptional activation	7.59556955927812e-05	-9.48536034038751	81	40	0.0615384615384615	650	2227	8886,7157,3398,4869,9913,7037,6135,661,11235,5366,4609,581,4831,3320,5292,1977,993,6881,2597,7083,6470,1019,1871,3939,1973,4691,6875,8464,7343,3658,654364,3308,8607,332,5757,3159,6883,57678,8061,86	DDX18,TP53,ID2,NPM1,SUPT7L,TFRC,RPL11,POLR3D,PDCD10,PMAIP1,MYC,BAX,NME2,HSP90AA1,PIM1,EIF4E,CDC25A,TAF10,GAPDH,TK1,SHMT1,CDK4,E2F3,LDHA,EIF4A1,NCL,TAF4B,SUPT3H,UBTF,IREB2,NME1-NME2,HSPA4,RUVBL1,BIRC5,PTMA,HMGA1,TAF12,GPAM,FOSL1,ACTL6A
erbb1_downstream_pathway	ErbB1 downstream signaling	0.000350162070421118	-7.95711445231319	102	46	0.0707692307692308	650	2227	10163,673,5607,1848,1958,2475,5894,10096,5604,5900,81624,7531,9252,805,3725,466,55845,998,5518,4609,5601,6194,6548,253260,10097,5598,6774,1386,10006,9610,1843,64223,5170,10971,5868,2002,2353,7532,378,572,8976,6772,6722,7534,10109,7533	WASF2,BRAF,MAP2K5,DUSP6,EGR1,MTOR,RAF1,ACTR3,MAP2K1,RALGDS,DIAPH3,YWHAE,RPS6KA5,CALM2,JUN,ATF1,BRK1,CDC42,PPP2R1A,MYC,MAPK9,RPS6,SLC9A1,RICTOR,ACTR2,MAPK7,STAT3,ATF2,ABI1,RIN1,DUSP1,MLST8,PDPK1,YWHAQ,RAB5A,ELK1,FOS,YWHAG,ARF4,BAD,WASL,STAT1,SRF,YWHAZ,ARPC2,YWHAH
telomerasepathway	Regulation of Telomerase	0.000610182521848912	-7.40175242940738	66	32	0.0492307692307692	650	2227	23309,54984,5883,5810,5931,2475,10038,3183,4691,641,25942,7531,2353,8658,4084,7520,595,3725,54386,65057,4609,2547,26277,1027,6198,3320,10728,10284,3066,6667,8819,7014	SIN3B,PINX1,RAD9A,RAD1,RBBP7,MTOR,PARP2,HNRNPC,NCL,BLM,SIN3A,YWHAE,FOS,TNKS,MXD1,XRCC5,CCND1,JUN,TERF2IP,ACD,MYC,XRCC6,TINF2,CDKN1B,RPS6KB1,HSP90AA1,PTGES3,SAP18,HDAC2,SP1,SAP30,TERF2
mtor_4pathway	mTOR signaling pathway	0.00116799163126485	-6.75246955961474	60	29	0.0446153846153846	650	2227	5170,23291,673,1975,2475,5894,5604,10971,1973,54205,84335,7531,7532,6009,54541,7248,54700,1938,3551,6446,9776,6198,7534,253260,10891,7533,1977,8945,64223	PDPK1,FBXW11,BRAF,EIF4B,MTOR,RAF1,MAP2K1,YWHAQ,EIF4A1,CYCS,AKT1S1,YWHAE,YWHAG,RHEB,DDIT4,TSC1,RRN3,EEF2,IKBKB,SGK1,ATG13,RPS6KB1,YWHAZ,RICTOR,PPARGC1A,YWHAH,EIF4E,BTRC,MLST8
hdac_classi_pathway	Signaling events mediated by HDAC Class I	0.00144818119983418	-6.53744685484069	66	31	0.0476923076923077	650	2227	23411,23309,57459,5931,7024,51548,9219,4092,79084,22933,25942,10013,7329,53615,5566,2287,10014,4084,7341,54815,5903,7514,9759,10284,10419,6774,5970,7181,8945,3066,8819	SIRT1,SIN3B,GATAD2B,RBBP7,TFCP2,SIRT6,MTA2,SMAD7,WDR77,SIRT2,SIN3A,HDAC6,UBE2I,MBD3,PRKACA,FKBP3,HDAC5,MXD1,SUMO1,GATAD2A,RANBP2,XPO1,HDAC4,SAP18,PRMT5,STAT3,RELA,NR2C1,BTRC,HDAC2,SAP30
ps1pathway	Presenilin action in Notch and Wnt signaling	0.00213761098866946	-6.14806643397767	46	23	0.0353846153846154	650	2227	23291,51107,324,2353,1452,5663,4734,22943,595,3725,5467,1499,10023,4609,2932,4040,3516,6885,10454,23385,5528,8945,8321	FBXW11,APH1A,APC,FOS,CSNK1A1,PSEN1,NEDD4,DKK1,CCND1,JUN,PPARD,CTNNB1,FRAT1,MYC,GSK3B,LRP6,RBPJ,MAP3K7,TAB1,NCSTN,PPP2R5D,BTRC,FZD1
tnfpathway	TNF receptor signaling pathway	0.00266065464038609	-5.9291830810592	44	22	0.0338461538461538	650	2227	4215,6868,1540,5609,7128,330,7186,6609,1147,10399,857,329,8772,5606,8517,8878,3551,5584,6772,4217,6885,5970	MAP3K3,ADAM17,CYLD,MAP2K7,TNFAIP3,BIRC3,TRAF2,SMPD1,CHUK,GNB2L1,CAV1,BIRC2,FADD,MAP2K3,IKBKG,SQSTM1,IKBKB,PRKCI,STAT1,MAP3K5,MAP3K7,RELA
insulin_glucose_pathway	Insulin-mediated glucose transport	0.00285002604049057	-5.86042714772909	29	16	0.0246153846153846	650	2227	6517,23433,9322,208,4012,10971,6810,7531,7532,805,5584,2932,2997,7534,9882,7533	SLC2A4,RHOQ,TRIP10,AKT2,LNPEP,YWHAQ,STX4,YWHAE,YWHAG,CALM2,PRKCI,GSK3B,GYS1,YWHAZ,TBC1D4,YWHAH
foxm1pathway	FOXM1 transcription factor network	0.003511624992534	-5.65167638780177	37	19	0.0292307692307692	650	2227	1058,2931,1019,1063,2119,6502,5604,9212,2353,983,7515,595,675,332,4609,1163,11200,9133,6667	CENPA,GSK3A,CDK4,CENPF,ETV5,SKP2,MAP2K1,AURKB,FOS,CDK1,XRCC1,CCND1,BRCA2,BIRC5,MYC,CKS1B,CHEK2,CCNB2,SP1
p38alphabetadownstreampathway	Signaling mediated by p38-alpha and p38-beta	0.00437621843775578	-5.43157029788804	35	18	0.0276923076923077	650	2227	7867,7157,8550,5868,4205,9252,3725,466,7391,5743,26959,4286,6548,22926,10891,1977,1386,1649	MAPKAPK3,TP53,MAPKAPK5,RAB5A,MEF2A,RPS6KA5,JUN,ATF1,USF1,PTGS2,HBP1,MITF,SLC9A1,ATF6,PPARGC1A,EIF4E,ATF2,DDIT3
p53regulationpathway	p53 pathway	0.00458248609388188	-5.3855136128689	59	27	0.0415384615384615	650	2227	84148,1455,1454,8493,6502,7157,1434,4194,1111,1452,10155,6125,1877,6135,890,9349,1616,387893,5300,53944,5601,2932,545,11200,10848,10419,1456	KAT8,CSNK1G2,CSNK1E,PPM1D,SKP2,TP53,CSE1L,MDM4,CHEK1,CSNK1A1,TRIM28,RPL5,E4F1,RPL11,CCNA2,RPL23,DAXX,KMT5A,PIN1,CSNK1G1,MAPK9,GSK3B,ATR,CHEK2,PPP1R13L,PRMT5,CSNK1G3
nfkappabcanonicalpathway	Canonical NF-kappaB pathway	0.00538124667209834	-5.22483520821382	23	13	0.02	650	2227	7323,8517,7514,1540,7128,8767,3551,10892,1147,5970,329,23085,8945	UBE2D3,IKBKG,XPO1,CYLD,TNFAIP3,RIPK2,IKBKB,MALT1,CHUK,RELA,BIRC2,ERC1,BTRC
circadianpathway	Circadian rhythm pathway	0.0066380617913975	-5.01493525699049	14	9	0.0138461538461538	650	2227	5187,1454,406,1111,545,8553,9575,11091,9572	PER1,CSNK1E,ARNTL,CHEK1,ATR,BHLHE40,CLOCK,WDR5,NR1D1
myc_pathway	C-MYC pathway	0.0108034469163045	-4.52789003685526	22	12	0.0184615384615385	650	2227	8464,7709,26959,6881,8607,5300,4609,6502,2932,6883,9913,86	SUPT3H,ZBTB17,HBP1,TAF10,RUVBL1,PIN1,MYC,SKP2,GSK3B,TAF12,SUPT7L,ACTL6A
erbb2erbb3pathway	ErbB2/ErbB3 signaling events	0.0114526029269322	-4.46953824495433	35	17	0.0261538461538462	650	2227	4771,2475,5894,9101,5604,2353,5566,572,3725,6464,10193,5601,5781,3717,4776,2065,6774	NF2,MTOR,RAF1,USP8,MAP2K1,FOS,PRKACA,BAD,JUN,SHC1,RNF41,MAPK9,PTPN11,JAK2,NFATC4,ERBB3,STAT3
met_pathway	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	0.0145446170190093	-4.23053431814758	72	30	0.0461538461538462	650	2227	5058,5170,57610,3636,1958,4690,2475,2060,1495,208,5894,5604,5868,324,84335,30011,3725,1399,572,5770,1499,998,8976,5781,382,4233,1977,3837,8650,64223	PAK1,PDPK1,RANBP10,INPPL1,EGR1,NCK1,MTOR,EPS15,CTNNA1,AKT2,RAF1,MAP2K1,RAB5A,APC,AKT1S1,SH3KBP1,JUN,CRKL,BAD,PTPN1,CTNNB1,CDC42,WASL,PTPN11,ARF6,MET,EIF4E,KPNB1,NUMB,MLST8
hedgehog_glipathway	Hedgehog signaling events mediated by Gli proteins	0.0152127724528982	-4.18561991102455	44	20	0.0307692307692308	650	2227	23309,1455,23291,5931,1454,5604,26160,25942,1452,5566,8405,7514,53944,2932,10284,8945,3066,1456,2735,8819	SIN3B,CSNK1G2,FBXW11,RBBP7,CSNK1E,MAP2K1,IFT172,SIN3A,CSNK1A1,PRKACA,SPOP,XPO1,CSNK1G1,GSK3B,SAP18,BTRC,HDAC2,CSNK1G3,GLI1,SAP30
erbb1_internalization_pathway	Internalization of ErbB1	0.0199044018505842	-3.91681437319066	34	16	0.0246153846153846	650	2227	7323,10617,5894,2060,9101,868,29924,5868,51652,8867,30011,998,7322,7251,10253,6453	UBE2D3,STAMBP,RAF1,EPS15,USP8,CBLB,EPN1,RAB5A,CHMP3,SYNJ1,SH3KBP1,CDC42,UBE2D2,TSG101,SPRY2,ITSN1
foxopathway	FoxO family signaling	0.0212196038039257	-3.85282981685063	48	21	0.0323076923076923	650	2227	23411,1455,1454,6502,10971,1147,7531,1452,7763,7532,7514,1499,53944,5601,3551,604,6446,1027,7534,7533,1456	SIRT1,CSNK1G2,CSNK1E,SKP2,YWHAQ,CHUK,YWHAE,CSNK1A1,ZFAND5,YWHAG,XPO1,CTNNB1,CSNK1G1,MAPK9,IKBKB,BCL6,SGK1,CDKN1B,YWHAZ,YWHAH,CSNK1G3
mapktrkpathway	Trk receptor signaling mediated by the MAPK pathway	0.0224184859930601	-3.79786939291984	29	14	0.0215384615384615	650	2227	673,5607,1958,5608,5894,5604,6722,6016,5598,2002,2353,9252,5606,23623	BRAF,MAP2K5,EGR1,MAP2K6,RAF1,MAP2K1,SRF,RIT1,MAPK7,ELK1,FOS,RPS6KA5,MAP2K3,RUSC1
ecadherin_stabilization_pathway	Stabilization and expansion of the E-cadherin adherens junction	0.0233510892154814	-3.75711164861123	40	18	0.0276923076923077	650	2227	4690,51474,1495,87,6810,1729,7791,7408,1499,1969,60412,1500,1942,4233,382,7414,10006,4026	NCK1,LIMA1,CTNNA1,ACTN1,STX4,DIAPH1,ZYX,VASP,CTNNB1,EPHA2,EXOC4,CTNND1,EFNA1,MET,ARF6,VCL,ABI1,LPP
e2f_pathway	E2F transcription factor network	0.0266315276337776	-3.62565951565788	72	29	0.0446153846153846	650	2227	1876,23411,993,6595,7083,11073,8936,5422,8409,1875,6240,1871,6241,990,4998,983,10155,7515,26959,840,890,5933,7030,4609,1027,10419,1870,4172,6667	E2F6,SIRT1,CDC25A,SMARCA2,TK1,TOPBP1,WASF1,POLA1,UXT,E2F5,RRM1,E2F3,RRM2,CDC6,ORC1,CDK1,TRIM28,XRCC1,HBP1,CASP7,CCNA2,RBL1,TFE3,MYC,CDKN1B,PRMT5,E2F2,MCM3,SP1
plk3_pathway	PLK3 signaling events	0.0276686292486156	-3.58745602567259	5	4	0.00615384615384615	650	2227	1263,11200,995,7157	PLK3,CHEK2,CDC25C,TP53
rhoa_pathway	RhoA signaling pathway	0.0306263305805463	-3.48589516353302	41	18	0.0276923076923077	650	2227	4659,7094,57591,8394,2353,1729,5606,3725,5586,998,3491,5608,6548,1027,6722,7414,1386,9475	PPP1R12A,TLN1,MKL1,PIP5K1A,FOS,DIAPH1,MAP2K3,JUN,PKN2,CDC42,CYR61,MAP2K6,SLC9A1,CDKN1B,SRF,VCL,ATF2,ROCK2
arf6_traffickingpathway	Arf6 trafficking events	0.032101994457179	-3.43883711815392	44	19	0.0292307692307692	650	2227	6517,3728,1495,9341,23162,3831,154,6382,966,9043,1499,1213,1785,3688,60412,1500,55770,382,1363	SLC2A4,JUP,CTNNA1,VAMP3,MAPK8IP3,KLC1,ADRB2,SDC1,CD59,SPAG9,CTNNB1,CLTC,DNM2,ITGB1,EXOC4,CTNND1,EXOC2,ARF6,CPE
p38_mk2pathway	p38 signaling mediated by MAPKAP kinases	0.0394355367222496	-3.23308792192305	20	10	0.0153846153846154	650	2227	7867,5894,6929,10971,6722,7534,7531,7533,2115,7532	MAPKAPK3,RAF1,TCF3,YWHAQ,SRF,YWHAZ,YWHAE,YWHAH,ETV1,YWHAG
lkb1_pathway	LKB1 signaling events	0.0394616219868184	-3.23242667465012	42	18	0.0276923076923077	650	2227	23387,2475,7157,10971,84335,7531,5566,7532,200186,7248,114790,4609,2932,7534,3320,7533,11140,64223	SIK3,MTOR,TP53,YWHAQ,AKT1S1,YWHAE,PRKACA,YWHAG,CRTC2,TSC1,STK11IP,MYC,GSK3B,YWHAZ,HSP90AA1,YWHAH,CDC37,MLST8
wnt_canonical_pathway	Canonical Wnt signaling pathway	0.0419113913829021	-3.17219761829054	31	14	0.0215384615384615	650	2227	23291,1499,5518,53944,1454,2932,4040,324,857,59349,1452,8945,1856,55361	FBXW11,CTNNB1,PPP2R1A,CSNK1G1,CSNK1E,GSK3B,LRP6,APC,CAV1,KLHL12,CSNK1A1,BTRC,DVL2,PI4K2A
hif1apathway	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0423347619493285	-3.16214673492653	15	8	0.0123076923076923	650	2227	55662,6921,10399,3320,405,10987,8453,7157	HIF1AN,TCEB1,GNB2L1,HSP90AA1,ARNT,COPS5,CUL2,TP53
bard1pathway	BARD1 signaling events	0.0522613188610056	-2.95149878267911	29	13	0.02	650	2227	7323,2130,5111,2176,11073,2547,7157,2177,4869,545,2189,1477,7520	UBE2D3,EWSR1,PCNA,FANCC,TOPBP1,XRCC6,TP53,FANCD2,NPM1,ATR,FANCG,CSTF1,XRCC5
il1pathway	IL1-mediated signaling events	0.0575812815282169	-2.85455773756407	35	15	0.0230769230769231	650	2227	4215,3725,8517,8878,5608,3551,5584,7335,1147,6885,10454,5970,7334,23085,100302736	MAP3K3,JUN,IKBKG,SQSTM1,MAP2K6,IKBKB,PRKCI,UBE2V1,CHUK,MAP3K7,TAB1,RELA,UBE2N,ERC1,TMED7-TICAM2
nfkappabalternativepathway	Alternative NF-kappaB pathway	0.06394564502728	-2.74972185292778	6	4	0.00615384615384615	650	2227	5971,1147,4791,8945	RELB,CHUK,NFKB2,BTRC
aurora_b_pathway	Aurora B signaling	0.0746713082335202	-2.59465935388551	39	16	0.0246153846153846	650	2227	9918,1058,10112,332,54888,55143,4869,4691,29127,11004,9212,64151,151648,3925,5528,10051	NCAPD2,CENPA,KIF20A,BIRC5,NSUN2,CDCA8,NPM1,NCL,RACGAP1,KIF2C,AURKB,NCAPG,SGOL1,STMN1,PPP2R5D,SMC4
hdac_classiii_pathway	Signaling events mediated by HDAC Class III	0.0746713082335202	-2.59465935388551	39	16	0.0246153846153846	650	2227	23411,8367,7157,2274,8363,22933,4209,8368,8360,8365,8362,9759,8364,2547,581,10891	SIRT1,HIST1H4E,TP53,FHL2,HIST1H4J,SIRT2,MEF2D,HIST1H4L,HIST1H4D,HIST1H4H,HIST1H4K,HDAC4,HIST1H4C,XRCC6,BAX,PPARGC1A
plk_pathway	Polo-like kinase signaling events in the cell cycle	0.0775032685430496	-2.55743516876314	4	3	0.00461538461538462	650	2227	1263,10769,10733	PLK3,PLK2,PLK4
rac1_pathway	RAC1 signaling pathway	0.0779711498911886	-2.55141639390239	54	21	0.0323076923076923	650	2227	10163,5058,10152,5609,8936,1495,10096,29127,8394,5606,3725,1499,55845,5608,5601,4296,10097,10109,6774,1386,10006	WASF2,PAK1,ABI2,MAP2K7,WASF1,CTNNA1,ACTR3,RACGAP1,PIP5K1A,MAP2K3,JUN,CTNNB1,BRK1,MAP2K6,MAPK9,MAP3K11,ACTR2,ARPC2,STAT3,ATF2,ABI1
plk2_4pathway	PLK2 and PLK4 events	0.0850966917088221	-2.46396711949546	2	2	0.00307692307692308	650	2227	10769,10733	PLK2,PLK4
smad2_3nuclearpathway	Regulation of nuclear SMAD2/3 signaling	0.0879880030616965	-2.43055480264191	76	28	0.0430769230769231	650	2227	1030,23309,7709,7050,79753,5931,2908,1019,6929,3312,4092,467,25942,2353,1482,6498,3725,7421,5933,7030,4609,51586,55802,10284,1386,3066,6667,8819	CDKN2B,SIN3B,ZBTB17,TGIF1,SNIP1,RBBP7,NR3C1,CDK4,TCF3,HSPA8,SMAD7,ATF3,SIN3A,FOS,NKX2-5,SKIL,JUN,VDR,RBL1,TFE3,MYC,MED15,DCP1A,SAP18,ATF2,HDAC2,SP1,SAP30
p75ntrpathway	p75(NTR)-mediated signaling	0.0919633859152996	-2.38636476032935	61	23	0.0353846153846154	650	2227	627,6868,6272,8767,51107,842,7157,56616,57142,1147,54205,7531,5663,56160,572,8517,8878,6464,27018,5601,3551,5584,23385	BDNF,ADAM17,SORT1,RIPK2,APH1A,CASP9,TP53,DIABLO,RTN4,CHUK,CYCS,YWHAE,PSEN1,NDNL2,BAD,IKBKG,SQSTM1,SHC1,NGFRAP1,MAPK9,IKBKB,PRKCI,NCSTN
caspase_pathway	Caspase cascade in apoptosis	0.111108623149972	-2.19724696923717	50	19	0.0292307692307692	650	2227	330,55367,8738,7186,842,56616,54205,837,329,4000,4926,840,4001,835,7020,581,3875,6709,7150	BIRC3,PIDD1,CRADD,TRAF2,CASP9,DIABLO,CYCS,CASP4,BIRC2,LMNA,NUMA1,CASP7,LMNB1,CASP2,TFAP2A,BAX,KRT18,SPTAN1,TOP1
nfat_3pathway	Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.130899995823569	-2.03332163797179	51	19	0.0292307692307692	650	2227	3164,10971,1827,4209,7531,1452,8021,5566,7532,805,572,5581,7514,5601,2932,7534,5292,7533,3837	NR4A1,YWHAQ,RCAN1,MEF2D,YWHAE,CSNK1A1,NUP214,PRKACA,YWHAG,CALM2,BAD,PRKCE,XPO1,MAPK9,GSK3B,YWHAZ,PIM1,YWHAH,KPNB1
ecadherin_nascentaj_pathway	E-cadherin signaling in the nascent adherens junction	0.135095846635976	-2.00177077737549	33	13	0.02	650	2227	595,10163,27252,3728,998,1499,1495,8907,1500,7082,2017,382,10006	CCND1,WASF2,KLHL20,JUP,CDC42,CTNNB1,CTNNA1,AP1M1,CTNND1,TJP1,CTTN,ARF6,ABI1
il12_2pathway	IL12-mediated signaling events	0.145924499304228	-1.92466591908386	61	22	0.0338461538461538	650	2227	3122,8767,2475,7879,567,2353,7297,3105,5606,3592,8651,5608,6778,4616,6772,5971,3717,4791,6774,1386,5970,56848	HLA-DRA,RIPK2,MTOR,RAB7A,B2M,FOS,TYK2,HLA-A,MAP2K3,IL12A,SOCS1,MAP2K6,STAT6,GADD45B,STAT1,RELB,JAK2,NFKB2,STAT3,ATF2,RELA,SPHK2
atf2_pathway	ATF-2 transcription factor network	0.150428246703352	-1.89426907457298	55	20	0.0307692307692308	650	2227	3280,4763,122953,1019,5451,467,2353,1847,3725,595,890,3569,5601,3726,11221,10891,1386,1649,1466,1843	HES1,NF1,JDP2,CDK4,POU2F1,ATF3,FOS,DUSP5,JUN,CCND1,CCNA2,IL6,MAPK9,JUNB,DUSP10,PPARGC1A,ATF2,DDIT3,CSRP2,DUSP1
ifngpathway	IFN-gamma pathway	0.160435289877209	-1.82986459604545	40	15	0.0230769230769231	650	2227	1399,805,817,8651,2475,5781,6772,5604,10379,4092,4296,3717,3459,6774,80142	CRKL,CALM2,CAMK2D,SOCS1,MTOR,PTPN11,STAT1,MAP2K1,IRF9,SMAD7,MAP3K11,JAK2,IFNGR1,STAT3,PTGES2
hif2pathway	HIF-2-alpha transcription factor network	0.163232627087137	-1.81257893555658	34	13	0.02	650	2227	23411,112398,5230,55662,6921,4891,1942,10370,8553,2002,112399,405,6667	SIRT1,EGLN2,PGK1,HIF1AN,TCEB1,SLC11A2,EFNA1,CITED2,BHLHE40,ELK1,EGLN3,ARNT,SP1
a6b1_a6b4_integrin_pathway	a6b1 and a6b4 Integrin signaling	0.164117969879882	-1.80716978121484	31	12	0.0184615384615385	650	2227	840,6464,5376,3688,10971,6198,7534,2065,7531,4233,7533,7532	CASP7,SHC1,PMP22,ITGB1,YWHAQ,RPS6KB1,YWHAZ,ERBB3,YWHAE,MET,YWHAH,YWHAG
aurora_a_pathway	Aurora A signaling	0.164117969879882	-1.80716978121484	31	12	0.0184615384615385	650	2227	5058,1058,9787,332,51343,7157,84962,2932,9212,5566,5528,54998	PAK1,CENPA,DLGAP5,BIRC5,FZR1,TP53,AJUBA,GSK3B,AURKB,PRKACA,PPP2R5D,AURKAIP1
igf1_pathway	IGF1 pathway	0.16450341839509	-1.80482392847536	28	11	0.0169230769230769	650	2227	5170,1399,572,5770,6464,5894,5781,7534,6198,10399,7531	PDPK1,CRKL,BAD,PTPN1,SHC1,RAF1,PTPN11,YWHAZ,RPS6KB1,GNB2L1,YWHAE
tcrraspathway	Ras signaling in the CD4+ TCR pathway	0.192251098799426	-1.64895295514106	11	5	0.00769230769230769	650	2227	673,2002,2353,5894,5604	BRAF,ELK1,FOS,RAF1,MAP2K1
ranbp2pathway	Sumoylation by RanBP2 regulates transcriptional repression	0.192251098799426	-1.64895295514106	11	5	0.00769230769230769	650	2227	5903,7514,9759,7329,7341	RANBP2,XPO1,HDAC4,UBE2I,SUMO1
faspathway	FAS (CD95) signaling pathway	0.194085925454089	-1.63945430326478	35	13	0.02	650	2227	5170,8517,5609,330,5608,3551,5601,1213,6609,1147,5981,329,8772	PDPK1,IKBKG,MAP2K7,BIRC3,MAP2K6,IKBKB,MAPK9,CLTC,SMPD1,CHUK,RFC1,BIRC2,FADD
hivnefpathway	HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.194085925454089	-1.63945430326478	35	13	0.02	650	2227	840,5609,330,8738,1616,7186,842,835,54205,1147,4217,5970,8772	CASP7,MAP2K7,BIRC3,CRADD,DAXX,TRAF2,CASP9,CASP2,CYCS,CHUK,MAP3K5,RELA,FADD
syndecan_1_pathway	Syndecan-1-mediated signaling events	0.201741457060559	-1.6007683169142	17	7	0.0107692307692308	650	2227	682,5479,6386,4233,10855,5566,6382	BSG,PPIB,SDCBP,MET,HPSE,PRKACA,SDC1
cdc42_pathway	CDC42 signaling events	0.2045551141221	-1.58691783310015	70	24	0.0369230769230769	650	2227	5058,673,5609,2475,5894,1495,10096,324,81624,4735,5606,5581,3725,1499,998,5608,8976,5601,4296,2932,6198,10097,10109,1386	PAK1,BRAF,MAP2K7,MTOR,RAF1,CTNNA1,ACTR3,APC,DIAPH3,SEPT2,MAP2K3,PRKCE,JUN,CTNNB1,CDC42,MAP2K6,WASL,MAPK9,MAP3K11,GSK3B,RPS6KB1,ACTR2,ARPC2,ATF2
kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)	0.233761087342297	-1.45345567945781	52	18	0.0276923076923077	650	2227	5170,2241,161742,200734,5894,1796,5604,572,1399,8651,6464,4286,6772,5781,2932,6198,3717,6774	PDPK1,FER,SPRED1,SPRED2,RAF1,DOK1,MAP2K1,BAD,CRKL,SOCS1,SHC1,MITF,STAT1,PTPN11,GSK3B,RPS6KB1,JAK2,STAT3
insulin_pathway	Insulin Pathway	0.25059369442342	-1.38392239875445	43	15	0.0230769230769231	650	2227	5170,5770,23433,6464,9322,4690,208,1796,5781,60412,5584,6446,6198,55770,857	PDPK1,PTPN1,RHOQ,SHC1,TRIP10,NCK1,AKT2,DOK1,PTPN11,EXOC4,PRKCI,SGK1,RPS6KB1,EXOC2,CAV1
hdac_classii_pathway	Signaling events mediated by HDAC Class II	0.269284795297427	-1.31198574084976	34	12	0.0184615384615385	650	2227	5903,7514,9759,2908,604,6722,3320,10013,7531,7329,10014,7341	RANBP2,XPO1,HDAC4,NR3C1,BCL6,SRF,HSP90AA1,HDAC6,YWHAE,UBE2I,HDAC5,SUMO1
ar_tf_pathway	Regulation of Androgen receptor activity	0.2700436651203	-1.30917161039169	50	17	0.0261538461538462	650	2227	23411,6595,1958,8805,2908,5966,11143,5451,10399,3301,10513,3725,5608,2932,10481,3320,7181	SIRT1,SMARCA2,EGR1,TRIM24,NR3C1,REL,KAT7,POU2F1,GNB2L1,DNAJA1,APPBP2,JUN,MAP2K6,GSK3B,HOXB13,HSP90AA1,NR2C1
ceramide_pathway	Ceramide signaling pathway	0.284311007218241	-1.2576865441621	44	15	0.0230769230769231	650	2227	572,55512,330,8738,7186,5894,4609,6609,581,5604,427,54205,56848,5970,8772	BAD,SMPD3,BIRC3,CRADD,TRAF2,RAF1,MYC,SMPD1,BAX,MAP2K1,ASAH1,CYCS,SPHK2,RELA,FADD
ar_pathway	Coregulation of Androgen receptor activity	0.286696570529117	-1.24933086804396	57	19	0.0292307692307692	650	2227	3178,7050,10451,26524,7110,2274,7329,55818,5052,23028,7520,595,1499,2547,2185,6722,1021,23081,58190	HNRNPA1,TGIF1,VAV3,LATS2,TMF1,FHL2,UBE2I,KDM3A,PRDX1,KDM1A,XRCC5,CCND1,CTNNB1,XRCC6,PTK2B,SRF,CDK6,KDM4C,CTDSP1
fak_pathway	Signaling events mediated by focal adhesion kinase	0.294281002897913	-1.22322017595218	54	18	0.0276923076923077	650	2227	5058,23092,673,6237,7094,5894,5604,23162,87,9815,3725,595,8976,5601,2886,3688,7414,9475	PAK1,ARHGAP26,BRAF,RRAS,TLN1,RAF1,MAP2K1,MAPK8IP3,ACTN1,GIT2,JUN,CCND1,WASL,MAPK9,GRB7,ITGB1,VCL,ROCK2
tgfbrpathway	TGF-beta receptor signaling	0.302229107125167	-1.19656991635893	51	17	0.0261538461538462	650	2227	5170,83658,4092,23327,857,7531,9765,6498,1499,1490,6464,1616,23645,54778,6198,6885,11171	PDPK1,DYNLRB1,SMAD7,NEDD4L,CAV1,YWHAE,ZFYVE16,SKIL,CTNNB1,CTGF,SHC1,DAXX,PPP1R15A,RNF111,RPS6KB1,MAP3K7,STRAP
ecadherin_keratinocyte_pathway	E-cadherin signaling in keratinocytes	0.30534967878395	-1.18629767127376	19	7	0.0107692307692308	650	2227	84962,1500,7791,7408,8394,1495,208	AJUBA,CTNND1,ZYX,VASP,PIP5K1A,CTNNA1,AKT2
smad2_3pathway	Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.30534967878395	-1.18629767127376	19	7	0.0107692307692308	650	2227	805,5494,9972,7329,8021,3837,58190	CALM2,PPM1A,NUP153,UBE2I,NUP214,KPNB1,CTDSP1
pi3kplctrkpathway	Trk receptor signaling mediated by PI3K and PLC-gamma	0.317532039639345	-1.14717655349078	32	11	0.0169230769230769	650	2227	5170,595,572,6464,1958,2932,10971,7534,7531,7533,7532	PDPK1,CCND1,BAD,SHC1,EGR1,GSK3B,YWHAQ,YWHAZ,YWHAE,YWHAH,YWHAG
wnt_beta_catenin_pathway	Regulation of Wnt-mediated beta catenin signaling and target gene transcription	0.325454232404673	-1.12253343427131	78	25	0.0384615384615385	650	2227	7091,57167,607,3398,10971,324,7531,7532,6934,22943,5308,3725,595,26959,7514,1499,3491,57680,4609,4286,7534,6907,7533,8945,3066	TLE4,SALL4,BCL9,ID2,YWHAQ,APC,YWHAE,YWHAG,TCF7L2,DKK1,PITX2,JUN,CCND1,HBP1,XPO1,CTNNB1,CYR61,CHD8,MYC,MITF,YWHAZ,TBL1X,YWHAH,BTRC,HDAC2
p38gammadeltapathway	Signaling mediated by p38-gamma and p38-delta	0.328617542284867	-1.11286068988342	10	4	0.00615384615384615	650	2227	595,3925,5608,5606	CCND1,STMN1,MAP2K6,MAP2K3
bmppathway	BMP receptor signaling	0.349082167912636	-1.05244794634583	36	12	0.0184615384615385	650	2227	9765,659,23645,9241,4092,2932,5494,6885,4091,8021,654,58190	ZFYVE16,BMPR2,PPP1R15A,NOG,SMAD7,GSK3B,PPM1A,MAP3K7,SMAD6,NUP214,BMP6,CTDSP1
il6_7pathway	IL6-mediated signaling events	0.366377674210582	-1.00409058087002	43	14	0.0215384615384615	650	2227	3725,7184,3569,5608,4609,8543,3726,4286,5781,6772,3717,2353,6774,7297	JUN,HSP90B1,IL6,MAP2K6,MYC,LMO4,JUNB,MITF,PTPN11,STAT1,JAK2,FOS,STAT3,TYK2
epha2_fwdpathway	EPHA2 forward signaling	0.374056035188331	-0.983349666083738	17	6	0.00923076923076923	650	2227	52,5058,10451,1942,3636,1969	ACP1,PAK1,VAV3,EFNA1,INPPL1,EPHA2
il2_pi3kpathway	IL2 signaling events mediated by PI3K	0.390484381478707	-0.940367306715565	37	12	0.0184615384615385	650	2227	805,6464,2475,4609,6609,5781,6194,6198,3320,598,5970,8661	CALM2,SHC1,MTOR,MYC,SMPD1,PTPN11,RPS6,RPS6KB1,HSP90AA1,BCL2L1,RELA,EIF3A
s1p_s1p2_pathway	S1P2 pathway	0.400403147358987	-0.915283371035034	24	8	0.0123076923076923	650	2227	5058,3725,2768,2002,9294,2353,2771,2773	PAK1,JUN,GNA12,ELK1,S1PR2,FOS,GNAI2,GNAI3
s1p_s1p5_pathway	S1P5 pathway	0.427564404835171	-0.849650347367389	8	3	0.00461538461538462	650	2227	2768,2771,2773	GNA12,GNAI2,GNAI3
tcrcalciumpathway	Calcium signaling in the CD4+ TCR pathway	0.434549410307104	-0.833445623119255	28	9	0.0138461538461538	650	2227	3725,805,5743,3726,5451,1827,8061,5566,2353	JUN,CALM2,PTGS2,JUNB,POU2F1,RCAN1,FOSL1,PRKACA,FOS
erbb1_receptor_proximal_pathway	EGF receptor (ErbB1) signaling pathway	0.452283313380313	-0.793446495992708	25	8	0.0123076923076923	650	2227	5058,5770,7094,8976,5781,6772,2773,6774	PAK1,PTPN1,TLN1,WASL,PTPN11,STAT1,GNAI3,STAT3
il2_1pathway	IL2-mediated signaling events	0.452317753524927	-0.793370351610635	52	16	0.0246153846153846	650	2227	5894,5604,6777,2353,8027,5581,3725,8651,6464,4609,5601,6772,5781,2185,6774,5528	RAF1,MAP2K1,STAT5B,FOS,STAM,PRKCE,JUN,SOCS1,SHC1,MYC,MAPK9,STAT1,PTPN11,PTK2B,STAT3,PPP2R5D
avb3_opn_pathway	Osteopontin-mediated events	0.464455430170874	-0.766889677601336	32	10	0.0153846153846154	650	2227	5058,3725,10451,998,2185,1147,8394,2353,5970,9475	PAK1,JUN,VAV3,CDC42,PTK2B,CHUK,PIP5K1A,FOS,RELA,ROCK2
pdgfrapathway	PDGFR-alpha signaling pathway	0.472205013610109	-0.75034203683074	22	7	0.0107692307692308	650	2227	6722,1399,3725,857,6464,2002,2353	SRF,CRKL,JUN,CAV1,SHC1,ELK1,FOS
p38_mkk3_6pathway	p38 MAPK signaling pathway	0.482886260661612	-0.727974138233198	29	9	0.0138461538461538	650	2227	4215,805,5608,7186,4616,4217,6885,10454,5606	MAP3K3,CALM2,MAP2K6,TRAF2,GADD45B,MAP3K5,MAP3K7,TAB1,MAP2K3
hnf3apathway	FOXA1 transcription factor network	0.497684341397626	-0.69778925554219	43	13	0.02	650	2227	3725,8202,7494,4774,1027,5451,4782,4731,162,2353,4781,725,6667	JUN,NCOA3,XBP1,NFIA,CDKN1B,POU2F1,NFIC,NDUFV3,AP1B1,FOS,NFIB,C4BPB,SP1
ecadherin_1_pathway	E-cadherin signaling events	0.498648256647525	-0.695854328284913	2	1	0.00153846153846154	650	2227	1499	CTNNB1
glypican_2pathway	Glypican 2 network	0.498648256647525	-0.695854328284913	2	1	0.00153846153846154	650	2227	4192	MDK
prlsignalingeventspathway	Signaling events mediated by PRL	0.526308026680098	-0.641868635588981	23	7	0.0107692307692308	650	2227	7803,5876,890,8073,1958,22809,3688	PTP4A1,RABGGTB,CCNA2,PTP4A2,EGR1,ATF5,ITGB1
cd40_pathway	CD40/CD40L signaling	0.530170670819262	-0.634556303859713	30	9	0.0138461538461538	650	2227	3725,7128,330,7186,4609,5601,868,5970,329	JUN,TNFAIP3,BIRC3,TRAF2,MYC,MAPK9,CBLB,RELA,BIRC2
cdc42_reg_pathway	Regulation of CDC42 activity	0.530170670819262	-0.634556303859713	30	9	0.0138461538461538	650	2227	8412,10451,23268,998,10928,29127,324,23229,6453	BCAR3,VAV3,DNMBP,CDC42,RALBP1,RACGAP1,APC,ARHGEF9,ITSN1
cxcr3pathway	CXCR3-mediated signaling events	0.553782988982768	-0.590982385613459	34	10	0.0153846153846154	650	2227	5170,2475,5608,5894,5604,253260,2773,2771,5606,64223	PDPK1,MTOR,MAP2K6,RAF1,MAP2K1,RICTOR,GNAI3,GNAI2,MAP2K3,MLST8
myc_represspathway	Validated targets of C-MYC transcriptional repression	0.559778959830067	-0.580213287762416	62	18	0.0276923076923077	650	2227	1030,7709,6908,10397,84233,3956,3398,81855,22943,7812,595,5933,4609,4802,3688,1027,1649,6667	CDKN2B,ZBTB17,TBP,NDRG1,TMEM126A,LGALS1,ID2,SFXN3,DKK1,CSDE1,CCND1,RBL1,MYC,NFYC,ITGB1,CDKN1B,DDIT3,SP1
trkrpathway	Neurotrophic factor-mediated Trk receptor signaling	0.591925824991968	-0.524373947569958	56	16	0.0246153846153846	650	2227	595,1399,5058,627,6464,8878,998,9093,10287,5781,5604,5584,10755,23327,6016,6774	CCND1,CRKL,PAK1,BDNF,SHC1,SQSTM1,CDC42,DNAJA3,RGS19,PTPN11,MAP2K1,PRKCI,GIPC1,NEDD4L,RIT1,STAT3
rb_1pathway	Regulation of retinoblastoma protein	0.591925824991968	-0.524373947569958	56	16	0.0246153846153846	650	2227	3725,7343,23411,890,6046,26574,6872,6908,5894,5601,11016,4286,6502,1027,4233,1386	JUN,UBTF,SIRT1,CCNA2,BRD2,AATF,TAF1,TBP,RAF1,MAPK9,ATF7,MITF,SKP2,CDKN1B,MET,ATF2
cmyb_pathway	C-MYB transcription factor network	0.620131019734608	-0.477824501115788	78	22	0.0338461538461538	650	2227	3280,6595,3015,330,3312,5250,27044,25942,7329,10155,4173,595,5743,2114,5481,4609,8379,1027,5292,6885,1021,6667	HES1,SMARCA2,H2AFZ,BIRC3,HSPA8,SLC25A3,SND1,SIN3A,UBE2I,TRIM28,MCM4,CCND1,PTGS2,ETS2,PPID,MYC,MAD1L1,CDKN1B,PIM1,MAP3K7,CDK6,SP1
nfkappabatypicalpathway	Atypical NF-kappaB pathway	0.62015574369438	-0.477784632981249	14	4	0.00615384615384615	650	2227	5970,5966,8945,3551	RELA,REL,BTRC,IKBKB
s1p_s1p4_pathway	S1P4 pathway	0.62015574369438	-0.477784632981249	14	4	0.00615384615384615	650	2227	2768,998,2771,2773	GNA12,CDC42,GNAI2,GNAI3
cd8tcrdownstreampathway	Downstream signaling in naive CD8+ T cells	0.627344215681116	-0.466259900661038	50	14	0.0215384615384615	650	2227	3725,5581,805,673,1958,5894,3726,5601,5604,567,2002,2353,8061,3105	JUN,PRKCE,CALM2,BRAF,EGR1,RAF1,JUNB,MAPK9,MAP2K1,B2M,ELK1,FOS,FOSL1,HLA-A
reg_gr_pathway	Glucocorticoid receptor regulatory network	0.633228436756875	-0.4569240423866	82	23	0.0353846153846154	650	2227	1958,2908,6908,1081,3164,7157,5451,6777,2353,5566,3725,3569,5601,6772,581,6446,2932,7251,2289,3320,7533,5970,3066	EGR1,NR3C1,TBP,CGA,NR4A1,TP53,POU2F1,STAT5B,FOS,PRKACA,JUN,IL6,MAPK9,STAT1,BAX,SGK1,GSK3B,TSG101,FKBP5,HSP90AA1,YWHAH,RELA,HDAC2
arf_3pathway	Arf1 pathway	0.640211403828173	-0.445956838690038	18	5	0.00769230769230769	650	2227	8615,8394,9266,160,8729	USO1,PIP5K1A,CYTH2,AP2A1,GBF1
vegfr1_pathway	VEGFR1 specific signals	0.644772761479491	-0.438857332045067	29	8	0.0123076923076923	650	2227	5170,805,23607,4690,5781,857,3320,5566	PDPK1,CALM2,CD2AP,NCK1,PTPN11,CAV1,HSP90AA1,PRKACA
aurora_kinase_pathway	Signaling by Aurora kinases	0.645110563693543	-0.438333560297371	3	1	0.00153846153846154	650	2227	9212	AURKB
aurora_c_pathway	Aurora C signaling	0.645110563693543	-0.438333560297371	3	1	0.00153846153846154	650	2227	9212	AURKB
ephrinarevpathway	Ephrin A  reverse signaling	0.645110563693543	-0.438333560297371	3	1	0.00153846153846154	650	2227	2044	EPHA5
pi3kcibpathway	Class IB PI3K non-lipid kinase events	0.645110563693543	-0.438333560297371	3	1	0.00153846153846154	650	2227	5604	MAP2K1
a4b1_a4b7_pathway	a4b1 and a4b7 Integrin signaling	0.645110563693543	-0.438333560297371	3	1	0.00153846153846154	650	2227	3688	ITGB1
p53downstreampathway	Direct p53 effectors	0.651625663900946	-0.428285017055413	132	37	0.0569230769230769	650	2227	5564,55367,10397,3732,7157,3276,1434,6890,324,4292,6273,1847,54541,8812,3725,5111,57103,5366,2232,581,604,4436,7159,4233,6667,1843,1263,1643,665,467,857,639,22943,7421,1969,4802,3066	PRKAB1,PIDD1,NDRG1,CD82,TP53,PRMT1,CSE1L,TAP1,APC,MLH1,S100A2,DUSP5,DDIT4,CCNK,JUN,PCNA,TIGAR,PMAIP1,FDXR,BAX,BCL6,MSH2,TP53BP2,MET,SP1,DUSP1,PLK3,DDB2,BNIP3L,ATF3,CAV1,PRDM1,DKK1,VDR,EPHA2,NFYC,HDAC2
hif1_tfpathway	HIF-1-alpha transcription factor network	0.652376152001571	-0.427133963162182	65	18	0.0276923076923077	650	2227	10397,1906,3939,3398,4869,5209,8553,2353,7037,3725,5230,79365,10987,226,112399,10370,405,6667	NDRG1,EDN1,LDHA,ID2,NPM1,PFKFB3,BHLHE40,FOS,TFRC,JUN,PGK1,BHLHE41,COPS5,ALDOA,EGLN3,CITED2,ARNT,SP1
anthraxpathway	Cellular roles of Anthrax toxin	0.657449025743212	-0.41938804532237	22	6	0.00923076923076923	650	2227	805,5609,84168,5608,5606,5604	CALM2,MAP2K7,ANTXR1,MAP2K6,MAP2K3,MAP2K1
ephbfwdpathway	EPHB forward signaling	0.660562884192197	-0.414662952599044	33	9	0.0138461538461538	650	2227	5058,6237,998,4690,8867,8976,2886,6453,5604	PAK1,RRAS,CDC42,NCK1,SYNJ1,WASL,GRB7,ITSN1,MAP2K1
syndecan_2_pathway	Syndecan-2-mediated signaling events	0.660562884192197	-0.414662952599044	33	9	0.0138461538461538	650	2227	2335,4763,581,51399,3688,10399,6386,5566,2035	FN1,NF1,BAX,TRAPPC4,ITGB1,GNB2L1,SDCBP,PRKACA,EPB41
ncadherinpathway	N-cadherin signaling events	0.660562884192197	-0.414662952599044	33	9	0.0138461538461538	650	2227	805,2241,5770,221955,1499,1495,1500,2017,1639	CALM2,FER,PTPN1,DAGLB,CTNNB1,CTNNA1,CTNND1,CTTN,DCTN1
il27pathway	IL27-mediated signaling events	0.672698882396361	-0.396457475322016	26	7	0.0107692307692308	650	2227	3717,3592,6774,3569,7297,6773,6772	JAK2,IL12A,STAT3,IL6,TYK2,STAT2,STAT1
nephrin_neph1_pathway	Nephrin/Neph1 signaling in the kidney podocyte	0.672698882396361	-0.396457475322016	26	7	0.0107692307692308	650	2227	3725,572,7082,23607,4690,8976,5601	JUN,BAD,TJP1,CD2AP,NCK1,WASL,MAPK9
arf6downstreampathway	Arf6 downstream pathway	0.679643109299711	-0.386187457853452	15	4	0.00615384615384615	650	2227	9727,8394,382,8766	RAB11FIP3,PIP5K1A,ARF6,RAB11A
nfat_tfpathway	Calcineurin-regulated NFAT-dependent transcription in lymphocytes	0.679850019761721	-0.385883064312677	48	13	0.02	650	2227	3725,805,5743,5770,6520,1958,1019,3726,868,5451,1960,2353,8061	JUN,CALM2,PTGS2,PTPN1,SLC3A2,EGR1,CDK4,JUNB,CBLB,POU2F1,EGR3,FOS,FOSL1
il2_stat5pathway	IL2 signaling events mediated by STAT5	0.686446248993274	-0.376227354008796	30	8	0.0123076923076923	650	2227	890,6464,4609,5781,6777,598,1021,6667	CCNA2,SHC1,MYC,PTPN11,STAT5B,BCL2L1,CDK6,SP1
a4b1_paxdep_pathway	Paxillin-dependent events mediated by a4b1	0.692074482197551	-0.368061695923054	19	5	0.00769230769230769	650	2227	1399,382,5566,7094,3688	CRKL,ARF6,PRKACA,TLN1,ITGB1
vegfr1_2_pathway	Signaling events mediated by VEGFR1 and VEGFR2	0.697351848867242	-0.360465190905058	63	17	0.0261538461538462	650	2227	5170,5058,9175,4690,857,5566,4734,5606,805,1499,998,6464,5781,2185,3320,7414,405	PDPK1,PAK1,MAP3K13,NCK1,CAV1,PRKACA,NEDD4,MAP2K3,CALM2,CTNNB1,CDC42,SHC1,PTPN11,PTK2B,HSP90AA1,VCL,ARNT
fra_pathway	Validated transcriptional targets of AP1 family members Fra1 and Fra2	0.699003646466121	-0.358099320072204	34	9	0.0138461538461538	650	2227	595,3725,890,55787,3569,3726,8061,9988,6667	CCND1,JUN,CCNA2,TXLNG,IL6,JUNB,FOSL1,DMTF1,SP1
p38alphabetapathway	Regulation of p38-alpha and p38-beta	0.714659946097152	-0.33594844928574	27	7	0.0107692307692308	650	2227	4215,5058,11221,10454,5608,5606,1843	MAP3K3,PAK1,DUSP10,TAB1,MAP2K6,MAP2K3,DUSP1
syndecan_4_pathway	Syndecan-4-mediated signaling events	0.724919031890526	-0.321695310515154	31	8	0.0123076923076923	650	2227	4192,2335,84309,3688,1785,10755,87,6386	MDK,FN1,NUDT16L1,ITGB1,DNM2,GIPC1,ACTN1,SDCBP
ephrina_ephapathway	EphrinA-EPHA pathway	0.728778517747139	-0.316385409668489	8	2	0.00307692307692308	650	2227	2044,1969	EPHA5,EPHA2
et_egfrpathway	EGFR-dependent Endothelin signaling events	0.728778517747139	-0.316385409668489	8	2	0.00307692307692308	650	2227	2475,1906	MTOR,EDN1
avb3_integrin_pathway	Integrins in angiogenesis	0.731413286707906	-0.312776607301279	46	12	0.0184615384615385	650	2227	10451,5298,2335,7094,5781,2185,1027,6198,50848,3320,6382,7414	VAV3,PI4KB,FN1,TLN1,PTPN11,PTK2B,CDKN1B,RPS6KB1,F11R,HSP90AA1,SDC1,VCL
syndecan_pathway	Proteogylcan syndecan-mediated signaling events	0.748832746070737	-0.289239623377058	4	1	0.00153846153846154	650	2227	6382	SDC1
fcer1pathway	Fc-epsilon receptor I signaling in mast cells	0.758215618988461	-0.276787476021787	58	15	0.0230769230769231	650	2227	3725,8517,2241,5609,6464,5894,3551,1796,5781,5604,868,1147,2353,5970,1843	JUN,IKBKG,FER,MAP2K7,SHC1,RAF1,IKBKB,DOK1,PTPN11,MAP2K1,CBLB,CHUK,FOS,RELA,DUSP1
fgf_pathway	FGF signaling pathway	0.760538282678395	-0.273728829722139	47	12	0.0184615384615385	650	2227	5170,3725,6464,5781,6772,2185,6777,1500,2017,4233,2353,10253	PDPK1,JUN,SHC1,PTPN11,STAT1,PTK2B,STAT5B,CTNND1,CTTN,MET,FOS,SPRY2
tcptp_pathway	Signaling events mediated by TCPTP	0.767209800089373	-0.264994981655373	36	9	0.0138461538461538	650	2227	545,6777,5770,4233,6774,6778,3837,6772,3688	ATR,STAT5B,PTPN1,MET,STAT3,STAT6,KPNB1,STAT1,ITGB1
syndecan_3_pathway	Syndecan-3-mediated signaling events	0.778147210634327	-0.250839555949344	17	4	0.00615384615384615	650	2227	2017,5663,51107,23385	CTTN,PSEN1,APH1A,NCSTN
s1p_meta_pathway	Sphingosine 1-phosphate (S1P) pathway	0.779717906479396	-0.248823083072406	21	5	0.00769230769230769	650	2227	2768,9294,2771,56848,2773	GNA12,S1PR2,GNAI2,SPHK2,GNAI3
tcrjnkpathway	JNK signaling in the CD4+ TCR pathway	0.780025575988349	-0.248428570107419	13	3	0.00461538461538462	650	2227	1399,3725,6885	CRKL,JUN,MAP3K7
erbb_network_pathway	ErbB receptor signaling network	0.780025575988349	-0.248428570107419	13	3	0.00461538461538462	650	2227	145957,2065,3320	NRG4,ERBB3,HSP90AA1
trail_pathway	TRAIL signaling pathway	0.783014579008935	-0.244603963740746	25	6	0.00923076923076923	650	2227	8517,1147,7186,8772,6609,3551	IKBKG,CHUK,TRAF2,FADD,SMPD1,IKBKB
retinoic_acid_pathway	Retinoic acid receptors-mediated signaling	0.783014579008935	-0.244603963740746	25	6	0.00923076923076923	650	2227	7421,8202,5914,902,5566,983	VDR,NCOA3,RARA,CCNH,PRKACA,CDK1
angiopoietinreceptor_pathway	Angiopoietin receptor Tie2-mediated signaling	0.787434370317489	-0.238975251034639	48	12	0.0184615384615385	650	2227	5058,2335,6464,4690,2886,5781,3688,6777,6198,2002,5970,284	PAK1,FN1,SHC1,NCK1,GRB7,PTPN11,ITGB1,STAT5B,RPS6KB1,ELK1,RELA,ANGPT1
hes_heypathway	Notch-mediated HES/HEY network	0.787434370317489	-0.238975251034639	48	12	0.0184615384615385	650	2227	3280,817,3397,6929,1027,3717,1827,3516,9794,6774,405,23028	HES1,CAMK2D,ID1,TCF3,CDKN1B,JAK2,RCAN1,RBPJ,MAML1,STAT3,ARNT,KDM1A
botulinumtoxinpathway	Effects of Botulinum toxin	0.789707812976401	-0.236092258926934	9	2	0.00307692307692308	650	2227	6616,25782	SNAP25,RAB3GAP2
wnt_noncanonical_pathway	Noncanonical Wnt signaling pathway	0.817899909989515	-0.201015309291936	30	7	0.0107692307692308	650	2227	6885,998,2535,1452,10454,1856,5601	MAP3K7,CDC42,FZD2,CSNK1A1,TAB1,DVL2,MAPK9
arf6_pathway	Arf6 signaling events	0.820525461929996	-0.19781033672142	34	8	0.0123076923076923	650	2227	23527,1969,4690,154,1942,9266,382,4233	ACAP2,EPHA2,NCK1,ADRB2,EFNA1,CYTH2,ARF6,MET
rxr_vdr_pathway	RXR and RAR heterodimerization with other nuclear receptor	0.823626439343805	-0.194038202177903	14	3	0.00461538461538462	650	2227	7421,6198,3164	VDR,RPS6KB1,NR4A1
pdgfrbpathway	PDGFR-beta signaling pathway	0.838451564017657	-0.176198464422928	54	13	0.02	650	2227	2241,5770,6464,4690,4609,2886,1796,5781,6772,1785,52,6777,6774	FER,PTPN1,SHC1,NCK1,MYC,GRB7,DOK1,PTPN11,STAT1,DNM2,ACP1,STAT5B,STAT3
lis1pathway	Lissencephaly gene (LIS1) in neuronal migration and development	0.845019332772033	-0.168395772866526	31	7	0.0107692307692308	650	2227	8941,805,5049,998,7531,5528,10726	CDK5R2,CALM2,PAFAH1B2,CDC42,YWHAE,PPP2R5D,NUDC
bcr_5pathway	BCR signaling pathway	0.849962493101831	-0.162563056233897	66	16	0.0246153846153846	650	2227	5170,25998,5894,1796,5604,10892,1147,2002,2353,805,3725,8517,6464,3551,6885,5970	PDPK1,IBTK,RAF1,DOK1,MAP2K1,MALT1,CHUK,ELK1,FOS,CALM2,JUN,IKBKG,SHC1,IKBKB,MAP3K7,RELA
lpa4_pathway	LPA4-mediated signaling events	0.859622271853972	-0.151262204993854	15	3	0.00461538461538462	650	2227	5581,9252,5566	PRKCE,RPS6KA5,PRKACA
erbb4_pathway	ErbB4 signaling events	0.868800942437633	-0.14064124504519	32	7	0.0107692307692308	650	2227	1742,3717,145957,6777,6868,6464,4734	DLG4,JAK2,NRG4,STAT5B,ADAM17,SHC1,NEDD4
il12_stat4pathway	IL12 signaling mediated by STAT4	0.870254730142806	-0.138969316921498	28	6	0.00923076923076923	650	2227	3725,3122,2353,6774,5601,2119	JUN,HLA-DRA,FOS,STAT3,MAPK9,ETV5
alk1pathway	ALK1 signaling events	0.873401616757735	-0.135359786824381	24	5	0.00769230769230769	650	2227	1460,3397,857,659,4092	CSNK2B,ID1,CAV1,BMPR2,SMAD7
cxcr4_pathway	CXCR4-mediated signaling events	0.887048026593933	-0.119856153162095	76	18	0.0276923076923077	650	2227	5170,5058,3122,2475,9525,6777,10399,2870,6773,572,6772,3688,5781,2185,253260,3717,6774,64223	PDPK1,PAK1,HLA-DRA,MTOR,VPS4B,STAT5B,GNB2L1,GRK6,STAT2,BAD,STAT1,ITGB1,PTPN11,PTK2B,RICTOR,JAK2,STAT3,MLST8
epopathway	EPO signaling pathway	0.889496401748172	-0.117099817136625	33	7	0.0107692307692308	650	2227	1399,3717,6777,598,6464,5781,6772	CRKL,JAK2,STAT5B,BCL2L1,SHC1,PTPN11,STAT1
endothelinpathway	Endothelins	0.889844445913295	-0.116708611404436	53	12	0.0184615384615385	650	2227	5058,3725,5581,2768,998,5894,1906,5604,2185,6548,3717,2353	PAK1,JUN,PRKCE,GNA12,CDC42,RAF1,EDN1,MAP2K1,PTK2B,SLC9A1,JAK2,FOS
reelinpathway	Reelin signaling pathway	0.891914036505998	-0.114385522676219	29	6	0.00923076923076923	650	2227	9181,1399,2932,5609,3688,4296	ARHGEF2,CRKL,GSK3B,MAP2K7,ITGB1,MAP3K11
nectin_pathway	Nectin adhesion pathway	0.895998376193139	-0.109816678293291	25	5	0.00769230769230769	650	2227	50848,998,1499,7094,1495	F11R,CDC42,CTNNB1,TLN1,CTNNA1
rhoa_reg_pathway	Regulation of RhoA activity	0.904004988940109	-0.10092039986613	46	10	0.0153846153846154	650	2227	10451,9138,1894,9639,116985,4983,1027,9181,23365,9828	VAV3,ARHGEF1,ECT2,ARHGEF10,ARAP1,OPHN1,CDKN1B,ARHGEF2,ARHGEF12,ARHGEF17
ptp1bpathway	Signaling events mediated by PTP1B	0.904077846923075	-0.100839808444587	50	11	0.0169230769230769	650	2227	2241,5770,6464,1796,3717,6777,4904,857,6774,10253,7297	FER,PTPN1,SHC1,DOK1,JAK2,STAT5B,YBX1,CAV1,STAT3,SPRY2,TYK2
ret_pathway	Signaling events regulated by Ret tyrosine kinase	0.905476263259567	-0.0992942159618774	38	8	0.0123076923076923	650	2227	9260,3725,6464,4690,2886,1796,5781,5566	PDLIM7,JUN,SHC1,NCK1,GRB7,DOK1,PTPN11,PRKACA
rapid_gr_pathway	Rapid glucocorticoid signaling	0.91106178869211	-0.0931445588936478	7	1	0.00153846153846154	650	2227	5601	MAPK9
a4b1_paxindep_pathway	Paxillin-independent events mediated by a4b1 and a4b7	0.921819389006042	-0.0814059650635614	22	4	0.00615384615384615	650	2227	1399,3717,382,3688	CRKL,JAK2,ARF6,ITGB1
ar_nongenomic_pathway	Nongenotropic Androgen signaling	0.931804471074632	-0.0706322812908928	18	3	0.00461538461538462	650	2227	2353,5894,5604	FOS,RAF1,MAP2K1
glypican_3pathway	Glypican 3 network	0.937102255971239	-0.0649628714587796	8	1	0.00153846153846154	650	2227	5601	MAPK9
alphasynuclein_pathway	Alpha-synuclein signaling	0.93933903743515	-0.0625788027098989	32	6	0.00923076923076923	650	2227	2185,572,1861,5528,11315,6622	PTK2B,BAD,TOR1A,PPP2R5D,PARK7,SNCA
s1p_s1p3_pathway	S1P3 pathway	0.944097853692893	-0.0575254596358348	28	5	0.00769230769230769	650	2227	2768,3717,9294,2771,2773	GNA12,JAK2,S1PR2,GNAI2,GNAI3
wnt_signaling_pathway	Wnt signaling network	0.944097853692893	-0.0575254596358348	28	5	0.00769230769230769	650	2227	4040,2535,22943,8321,10159	LRP6,FZD2,DKK1,FZD1,ATP6AP2
notch_pathway	Notch signaling pathway	0.947998968243661	-0.0534018650782762	58	12	0.0184615384615385	650	2227	595,51107,2060,4609,6502,3516,9794,8766,23385,8945,8650,23028	CCND1,APH1A,EPS15,MYC,SKP2,RBPJ,MAML1,RAB11A,NCSTN,BTRC,NUMB,KDM1A
s1p_s1p1_pathway	S1P1 pathway	0.958920149332466	-0.0419474720779293	20	3	0.00461538461538462	650	2227	5743,2771,2773	PTGS2,GNAI2,GNAI3
tcr_pathway	TCR signaling in naive CD4+ T cells	0.962378753015539	-0.0383471916481439	60	12	0.0184615384615385	650	2227	5170,5581,3122,8517,6464,998,4690,6786,3551,5781,10892,1147	PDPK1,PRKCE,HLA-DRA,IKBKG,SHC1,CDC42,NCK1,STIM1,IKBKB,PTPN11,MALT1,CHUK
cd8tcrpathway	TCR signaling in naive CD8+ T cells	0.966273392076329	-0.0343084702389197	48	9	0.0138461538461538	650	2227	5170,5581,8517,6786,3551,10892,1147,567,3105	PDPK1,PRKCE,IKBKG,STIM1,IKBKB,MALT1,CHUK,B2M,HLA-A
lysophospholipid_pathway	LPA receptor mediated events	0.967332449317723	-0.0332130480751843	65	13	0.02	650	2227	3725,5581,2768,9170,7205,3569,9138,2932,2185,2353,2771,5970,2773	JUN,PRKCE,GNA12,LPAR2,TRIP6,IL6,ARHGEF1,GSK3B,PTK2B,FOS,GNAI2,RELA,GNAI3
hnf3bpathway	FOXA2 and FOXA3 transcription factor networks	0.968251107395691	-0.0322638168794958	44	8	0.0123076923076923	650	2227	3157,3033,2908,4763,7037,7351,6667,5105	HMGCS1,HADH,NR3C1,NF1,TFRC,UCP2,SP1,PCK1
epha_fwdpathway	EPHA forward signaling	0.971142695969361	-0.0292818637441082	31	5	0.00769230769230769	650	2227	1399,2044,10451,1942,1969	CRKL,EPHA5,VAV3,EFNA1,EPHA2
pi3kcipathway	Class I PI3K signaling events	0.976099780259357	-0.0241904639222789	41	7	0.0107692307692308	650	2227	5170,6446,3320,3636,382,9266,59339	PDPK1,SGK1,HSP90AA1,INPPL1,ARF6,CYTH2,PLEKHA2
alk2pathway	ALK2 signaling events	0.977777724383049	-0.022472910460305	11	1	0.00153846153846154	650	2227	659	BMPR2
il23pathway	IL23-mediated signaling events	0.9787263788226	-0.0215031659937951	37	6	0.00923076923076923	650	2227	3717,6774,5970,3569,7297,6772	JAK2,STAT3,RELA,IL6,TYK2,STAT1
il4_2pathway	IL4-mediated signaling events	0.981949564609293	-0.0182153318149713	60	11	0.0169230769230769	650	2227	6464,8651,2475,6778,604,6777,6198,3717,3159,6667,9655	SHC1,SOCS1,MTOR,STAT6,BCL6,STAT5B,RPS6KB1,JAK2,HMGA1,SP1,SOCS5
rac1_reg_pathway	Regulation of RAC1 activity	0.98636037760615	-0.0137334966267925	39	6	0.00923076923076923	650	2227	5910,9181,10451,29127,10006,10928	RAP1GDS1,ARHGEF2,VAV3,RACGAP1,ABI1,RALBP1
lymphangiogenesis_pathway	VEGFR3 signaling in lymphatic endothelium	0.99638634814661	-0.00362019686560317	23	2	0.00307692307692308	650	2227	2335,3688	FN1,ITGB1
amb2_neutrophils_pathway	amb2 Integrin signaling	0.998399785562205	-0.00160149614844175	48	6	0.00923076923076923	650	2227	3146,2335,1490,3491,7094,3569	HMGB1,FN1,CTGF,CYR61,TLN1,IL6
er_nongenomic_pathway	Plasma membrane estrogen receptor signaling	0.998581975676312	-0.00141903067164276	26	2	0.00307692307692308	650	2227	2100,9475	ESR2,ROCK2
txa2pathway	Thromboxane A2 receptor signaling	0.999100309110925	-0.000900095853836679	45	5	0.00769230769230769	650	2227	5581,5566,2771,8766,9138	PRKCE,PRKACA,GNAI2,RAB11A,ARHGEF1
hedgehog_2pathway	Signaling events mediated by the Hedgehog family	0.999517231027653	-0.000482885542806085	22	1	0.00153846153846154	650	2227	6491	STIL
cone_pathway	Visual signal transduction: Cones	0.999659543890714	-0.000340514077625166	23	1	0.00153846153846154	650	2227	388531	RGS9BP
rhodopsin_pathway	Visual signal transduction: Rods	0.999659543890714	-0.000340514077625166	23	1	0.00153846153846154	650	2227	388531	RGS9BP
ephrinbrevpathway	Ephrin B reverse signaling	0.999915952748413	-8.40507837546625e-05	27	1	0.00153846153846154	650	2227	6885	MAP3K7
glypicanpathway	Glypican pathway	0.99999999999508	-4.92009558095141e-12	3	0	0	650	2227
alk1_2pathway	ALK1 pathway	0.99999999999508	-4.92009558095141e-12	3	0	0	650	2227
hnf3pathway	FOXA transcription factor networks	0.99999999999508	-4.92009558095141e-12	3	0	0	650	2227
ephrinb_ephbpathway	EphrinB-EPHB pathway	1.00000000000506	5.05966286663134e-12	6	0	0	650	2227
glypican_1pathway	Glypican 1 network	1.00000000003993	3.99259043181226e-11	26	0	0	650	2227