TermID	Term	Enrichment	logP	Genes in Term	Target Genes in Term	Fraction of Targets in Term	Total Target Genes	Total Genes	Entrez Gene IDs	Gene Symbols
R-HSA-74160	Gene Expression	8.57383372622789e-69	-156.72965644139	1330	642	0.28207381370826	2276	8202	23019,196513,57505,8350,5252,6147,7587,9997,5707,6429,8665,6227,9972,6882,5094,64223,51095,7311,8731,3312,4774,3185,55644,60528,10421,8239,5432,10781,11051,5719,6233,115509,9377,56006,9282,6188,128312,8086,5689,23480,219749,171568,10775,10081,5715,6137,8894,9343,9862,92285,10419,58500,26986,79587,57459,170959,199704,9219,51639,55253,1974,5702,55814,113179,6746,6430,6875,79027,167227,6726,6158,10127,27258,129450,221785,388567,9818,7695,6996,285971,147923,10286,7586,28956,730087,7769,9572,55039,84967,284370,6881,2617,29982,79759,6169,10921,80032,6232,2958,6873,8362,7514,11102,90874,6201,8243,197320,2521,6637,23112,6908,6431,169841,10946,51058,9491,168374,661,83860,55802,79833,1349,7314,7965,5694,79691,83744,5931,1975,113802,6895,1973,5710,7316,23450,5917,7733,4686,1968,22835,51002,10128,8013,10197,7533,7745,9337,127396,25885,9939,83443,162239,80108,22869,10248,284459,11340,349075,6168,1983,1977,7551,55749,8331,10291,4234,118460,723790,11176,6160,9442,7247,85236,5571,4736,6009,2744,9128,54464,6619,7596,93474,348180,6884,5693,4092,5713,10949,7762,400720,10062,55571,6125,8347,9349,57103,112950,23658,54482,2965,9443,9794,5686,54811,10621,342132,23309,51504,6829,2100,80222,7025,25873,6257,51082,9167,389541,5434,11066,163049,79744,353355,6181,51276,147694,6235,7157,55659,6156,85456,5093,6135,1933,5687,25888,9441,55900,55746,2107,7539,10056,6207,27339,23411,6159,57711,11224,6629,10971,9631,79084,7697,10907,8021,3921,8667,6426,5903,1994,5933,5709,283337,23536,10284,2197,8891,8662,6146,51385,9521,6202,6122,9150,7978,10250,147687,54815,93134,1337,3726,2963,653604,3320,2959,10302,147837,8893,5692,7936,2908,7753,115196,8363,204851,11128,9416,6189,4848,5467,80778,3012,58492,6210,339487,201164,65988,3190,3516,6883,60559,90353,51503,23511,3015,5565,1964,10001,7531,79898,25942,16,51728,8365,125919,54938,6217,6134,1490,7752,6194,54778,5494,93587,23660,988,80110,11338,6731,4809,124454,6133,2649,208,54888,3021,8340,8661,1207,6498,5714,6208,10785,55290,9045,6747,2972,3066,6617,6627,3178,57343,64216,5440,5562,54205,23327,7702,6748,7633,56339,4849,23521,129401,10643,6184,23016,4609,6170,9330,1936,5915,23404,6154,6229,5393,7469,219988,8175,4781,5691,221830,155054,2058,51422,27316,51586,9329,6223,8892,4929,2101,29959,55599,146434,8664,10978,92595,51367,79074,29883,220988,79818,8364,103,90390,7181,8819,1350,902,5725,3183,1353,7884,10025,7728,11260,10155,7532,11198,27335,55954,7421,121274,1650,2074,7307,80139,1967,27068,3014,6173,283742,4306,6224,10594,201514,10667,25804,1915,7755,2962,284119,6139,3184,23438,26019,7565,6143,54512,2068,9439,7050,60487,9328,6144,6132,9589,148206,5430,5052,11335,6161,126231,8570,1478,6152,6878,3720,51204,2071,285268,7692,51241,9924,80153,10992,5696,9775,57721,9836,55703,6917,27257,3192,6222,163081,285521,84124,51520,23020,147929,199692,6167,7343,55663,7768,5690,10795,5705,5700,6231,22823,1340,7323,6209,6872,55621,6138,7699,3187,1482,23378,7270,23165,54541,9668,127253,8178,4927,84246,1938,6205,94039,6729,4904,55657,2960,24148,25799,64425,5431,7574,91975,6128,5682,6921,8368,6130,7248,54901,23636,7534,6907,7571,192669,79088,5564,51123,2475,1875,6193,11022,6635,29079,79595,3181,2193,54700,3376,2968,84987,5518,3191,6185,51692,10794,3017,26152,1477,79731,6877,5914,6734,26048,5695,23644,5451,6142,7556,11100,51585,6618,51637,53615,6203,8666,7453,152687,25904,10236,9861,9785,1030,8367,8480,53371,10482,7673,7376,6728,8360,7988,57209,56259,10189,6155,8125,5717,344787,146540,55778,6667,7296,1024,3164,7003,79862,6171,9669,55422,6626,3304,7638,9125,51592,148254,3188,1351,4782,6206,6428,6633	CNOT1,DCP1B,AARS2,HIST1H3A,PHF1,RPL23A,ZNF37A,SCO2,PSMD1,SRSF4,EIF3F,RPS21,NUP153,TAF11,PCBP2,MLST8,TRNT1,UBA52,RNMT,HSPA8,NFIA,HNRNPF,OSGEP,ELAC2,CD2BP2,USP9X,POLR2C,ZNF266,NUDT21,PSMD13,RPS27A,ZNF689,COX5A,SMG9,MED14,RPS3,HIST3H2BB,AAAS,PSMB1,SEC61G,ZNF25,POLR3H,POP4,PDCD7,PSMD9,RPL13,EIF2S2,EFTUD2,MED24,ZNF585B,PRMT5,ZNF250,PABPC1,CARS2,GATAD2B,ZNF431,ZNF585A,MTA2,SF3B6,TYW1,EIF4A2,PSMC3,BDP1,ADAT3,SSR2,SRSF5,TAF4B,ZNF655,DCP2,SRP9,RPL28,ZNF263,LSM3,TYW5,ZSCAN25,ZNF749,NUP58,ZNF136,TDG,ZNF775,ZNF420,BCAS2,ZKSCAN1,LAMTOR2,ZNF726,ZNF226,NR1D1,TRMT12,LSM10,ZNF615,TAF10,GARS,NRBF2,ZNF668,RPL38,RNPS1,ZNF556,RPS27,GTF2A2,TAF2,HIST1H4K,XPO1,RPP14,ZNF697,RPS7,SMC1A,ZNF778,FUS,SNRPG,TNRC6B,TBP,SRSF6,ZNF169,SF3A3,ZNF691,PSMF1,ZNF92,POLR3D,TAF3,DCP1A,GEMIN6,COX7B,UBB,AIMP2,PSMB6,QTRTD1,ZNF484,RBBP7,EIF4B,HENMT1,TARBP2,EIF4A1,PSMD4,UBC,SF3B3,RARS,ZNF180,NCBP1,EIF2S3,ZFP30,TPRKB,LRPPRC,NR4A3,PSME3,YWHAH,ZKSCAN8,CNOT8,ZNF684,POLR1A,RBM8A,SF3B5,ZFP1,ZFP2,ZNF510,POP7,HKR1,EXOSC8,ZNF713,RPL37A,EIF5,EIF4E,ZNF3,CCAR1,HIST1H2AJ,SF3A1,METTL1,EXOSC6,HIST2H2AA4,BAZ2A,RPL31,MED27,TSN,HIST1H2BK,PRKAG1,RPL10A,RHEB,GLS,PRPF4,XRN1,SNAPC3,ZNF45,ZNF670,CTU2,TAF13,PSMB5,SMAD7,PSMD7,HNRNPA0,ZNF215,ZNF772,NR1H3,CNOT11,RPL5,HIST1H2BC,RPL23,TIGAR,MED8,LSM5,TRMT13,GTF2H1,MED7,MAML1,PSMA5,ZNF562,POLR3F,ZNF774,SIN3B,TRMT112,SUPT5H,ESR2,TARS2,NR2F1,RPL36,RXRB,POLR1D,COX7A2L,LAMTOR4,POLR2E,SNRNP35,ZNF791,ZNF419,ZNF233,RPLP2,ZNF571,ZNF548,RPS29,TP53,ZNF416,RPL30,TNKS1BP1,PCBP1,RPL11,EEF1B2,PSMA6,ZNF473,MED26,ZNF302,NUP133,ETF1,ZFP37,FARSB,RPS13,PRPF19,SIRT1,RPL29,ZNF529,RPL35,SNRPB2,YWHAQ,NUP155,WDR77,ZNF138,TXNL4A,NUP214,RPSA,EIF3H,SRSF1,RANBP2,ELAVL1,RBL1,PSMD3,ZNF740,ADAT1,SAP18,FAU,EIF2B3,EIF3B,RPL22,ZNF589,EEF1E1,RPS8,RPL3,CTDP1,MTERF1,SRRM1,ZNF417,GATAD2A,ZNF561,COX6A1,JUNB,GTF2F2,HIST2H3D,HSP90AA1,GTF2B,SNAPC5,ZNF563,EIF2B5,PSMB4,NELFE,NR3C1,ZNF202,ZNF554,HIST1H4J,HIPK1,POLR3A,DDX23,RPS3A,CNOT2,PPARD,ZNF34,HIST1H2AE,ZNF77,RPS15A,ZBTB8OS,PLD6,ZNF747,HNRNPK,RBPJ,TAF12,SPCS3,CTU1,CWC15,NUP188,H2AFZ,PRKAB2,EIF1AX,MED6,YWHAE,ZNF613,SIN3A,AARS,POLR3K,HIST1H4H,ZNF543,SARS2,RPS16,RPL10,CTGF,ZNF200,RPS6,RNF111,PPM1A,TRMT10A,ZKSCAN5,CDC5L,ZNF614,U2AF2,SRP72,SNU13,EARS2,RPL9,NR6A1,AKT2,NSUN2,H3F3B,HIST1H2BL,EIF3A,CLNS1A,SKIL,PSMD8,RPS14,WDR4,BRF2,RPL14,SSR3,BRF1,HDAC2,SNAPC1,SNRPA1,HNRNPA1,ZNF304,TFB2M,POLR2K,PRKAA1,CYCS,NEDD4L,ZNF143,SSR4,ZNF79,METTL3,CNOT3,RPL13A,NUP35,IGF2BP3,RPN1,EXOSC7,MYC,RPL39,GTF3C3,EEF1D,RARB,EXOSC2,RPL26,RPS24,EXOSC9,NELFA,PATL1,SF3A2,NFIB,PSMB3,TWISTNB,ZNF425,EPRS,PRKAG2,RBMX,MED15,GTF3C4,RPS19,EIF2B2,NR4A2,ESRRA,NRBP1,RNPC3,ZNF597,EIF3D,CLP1,ZNF764,POP5,C2orf49,CNOT7,HNRNPA3,ZNF552,HIST1H4C,ADAR,MED30,NR2C1,SAP30,COX7C,CCNH,PTBP1,HNRNPC,COX11,SLBP,MED16,ZNF175,XPOT,TRIM28,YWHAG,SUPT16H,EIF3K,ZMAT5,VDR,ZNF641,DDOST,ERCC6,U2AF1,ZNF703,EIF2B1,PPA2,H2AFX,RPL36A,FAM98B,NR3C2,RPS20,PRPF8,ZNF584,FARS2,LSM4,EEF1A1,ZNF205,GTF2F1,PTRF,RPL17,HNRNPD,HARS2,UPF2,ZNF17,RPL19,EXOSC4,ERCC2,MED23,TGIF1,TRMT11,GTF3C5,RPL21,RPL8,WTAP,ZNF714,POLR2A,PRDX1,CBX3,RPL32,ZNF573,KHSRP,CSTF2,RPL24,TAF6,JARID2,TACO1,ERCC3,ZNF621,ZNF133,COX16,PAN2,EDC3,SF3B2,PSMB8,EIF4A3,METTL14,LCMT2,POLR3B,TCEA1,LSM1,HNRNPU,RPS18,ZNF567,COX18,ZNF394,LARS,SNRNP200,ZNF565,ZNF627,RPL37,UBTF,ZNF446,ZNF225,PSMB2,ZNF268,PSMC5,PSMC1,RPS26,MTF2,COX6B1,UBE2D3,RPS15,TAF1,TRMT1,RPL15,ZNF140,HNRNPH1,NKX2-5,RRP8,TTF1,NUP205,DDIT4,ZNF432,TYW3,ELL,NUP88,MED10,EEF2,RPS11,ZNF101,SRP54,YBX1,ZNF692,GTF2E1,PRPF6,ZNF324,POLR1E,POLR2B,ZNF26,ZNF300,RPL6,PSMA1,TCEB1,HIST1H4L,RPL7A,TSC1,CDKAL1,NUP62,YWHAZ,TBL1X,ZNF23,AGO3,ZNF426,PRKAB1,ZNF706,MTOR,E2F5,RPS5,TDRKH,SNRPE,MED4,SAP130,HNRNPA2B1,FARSA,RRN3,IARS,GTF2H4,COX14,PPP2R1A,HNRNPL,RPN2,CPSF3,ZNF460,HIST1H2BD,ZNF337,CSTF1,NARS2,TAF5,RARA,SRPR,ZNF500,PSMB7,EDC4,POU2F1,RPL18A,ZNF10,HNRNPUL1,PCF11,SNAPC2,C14orf166,MBD3,RPS9,EIF3G,WARS,ZNF595,CNOT10,HNRNPR,PSMD6,DHX38,CDKN2B,HIST1H4E,RAE1,NUP54,NXF1,ZNF222,NR1H2,SRP19,HIST1H4D,ZNF212,ZNF248,CTNNBL1,ALYREF,RPL27,ANP32A,PSMD11,ZNF860,ZNF785,ZNF839,SP1,TXNRD1,CDK8,NR4A1,TEAD1,ZNF669,RPL41,EIF5B,ZNF331,SNRPA,HSPA1B,ZNF221,RQCD1,TRIM33,ZNF555,HNRNPH2,COX8A,NFIC,RPS12,SRSF3,SNRPD2
R-HSA-1640170	Cell Cycle	5.41630928572513e-35	-78.9010636148806	572	293	0.128734622144112	2276	8202	5883,3015,23511,4869,8350,7531,55651,7329,79003,8365,1069,7465,9183,5707,26277,8379,9972,1021,8615,7311,5810,1454,4439,3021,9212,8340,79959,4171,5982,84296,4926,675,11190,5719,25936,6233,5714,91754,5527,128312,1870,8086,55957,22995,51433,5689,56158,51773,5715,129401,4000,2010,4174,4609,81876,57804,10426,7014,993,10274,10112,5422,5702,22994,5691,1859,5000,2801,23592,8481,9818,1029,80321,10383,9232,1460,5566,25836,54386,9918,595,890,4001,65057,8364,1027,84126,51434,4438,1032,2237,1639,23141,5984,5983,902,1871,701,6232,5884,8697,5861,7532,79682,3796,8318,5529,5889,8362,7514,79980,4085,8243,3014,5500,51720,7334,203068,4172,6396,29086,4292,641,4176,55055,9491,55320,91687,79172,7341,9702,6118,55835,85378,29781,7314,10051,10726,5694,11130,5931,140609,55755,29882,9025,5710,7316,23310,5001,8636,1062,57082,10197,54892,7533,55135,8945,23649,23291,2029,11004,4173,4218,5696,5111,51343,84131,10393,8331,7112,1058,723790,1019,23133,256126,85236,6241,990,983,7158,5690,84962,165918,11200,5705,7443,5700,5528,11258,5693,4175,4659,1063,5713,3978,1111,8347,23165,22897,4927,9738,80184,545,9735,5686,4999,5682,8368,84930,5108,996,4957,10806,4660,23636,7534,9133,5425,10142,8655,1875,7157,157570,5526,4998,64900,5424,132660,5687,55746,5518,10733,3017,348235,991,5695,10971,121441,9631,8021,995,5903,8607,5933,7336,5709,84515,7444,5981,23122,10776,9861,151648,255919,1030,1781,55388,114799,8367,8480,10540,144715,53371,55143,984,64151,10844,8360,26271,7153,151246,387893,653604,1163,5717,79019,3320,23595,9837,5692,29893,7156,6502,8363,10714,79866,401541,3012,332,147841,55125,11065,8556	RAD9A,H2AFZ,NUP188,NPM1,HIST1H3A,YWHAE,NHP2,UBE2I,MIS12,HIST1H4H,CETN2,WEE1,ZW10,PSMD1,TINF2,MAD1L1,NUP153,CDK6,USO1,UBA52,RAD1,CSNK1E,MSH5,H3F3B,AURKB,HIST1H2BL,CEP76,MCM2,RFC2,GINS4,NUMA1,BRCA2,CEP250,PSMD13,NSL1,RPS27A,PSMD8,NEK9,PPP2R5C,HIST3H2BB,E2F2,AAAS,LIN37,CEP152,ANAPC5,PSMB1,TEX12,RSF1,PSMD9,NUP35,LMNA,EMD,MCM5,MYC,RAB1B,POLD4,TUBGCP3,TERF2,CDC25A,STAG1,KIF20A,POLA1,PSMC3,CEP131,PSMB3,DYRK1A,ORC4,GOLGA2,LEMD3,OFD1,NUP58,CDKN2A,CEP70,TUBB4B,PTTG1,CSNK2B,PRKACA,NIPBL,TERF2IP,NCAPD2,CCND1,CCNA2,LMNB1,ACD,HIST1H4C,CDKN1B,ATRIP,ANAPC7,MSH4,CDKN2D,FEN1,DCTN1,ANKLE2,RFC4,RFC3,CCNH,E2F3,BUB1B,RPS27,RAD17,CDC23,RAB1A,YWHAG,CENPU,KIF2A,CDC45,PPP2R5E,RAD51C,HIST1H4K,XPO1,DSN1,MAD2L1,SMC1A,H2AFX,PPP1CB,UIMC1,UBE2N,TUBB,MCM3,SEC13,BABAM1,MLH1,BLM,MCM7,ZWILCH,PSMF1,MIS18BP1,CENPL,CENPO,SUMO1,CEP57,RPA2,CENPJ,TUBGCP6,NCAPH2,UBB,SMC4,NUDC,PSMB6,ZWINT,RBBP7,NEK7,CDK5RAP2,ANAPC2,RNF8,PSMD4,UBC,NCAPD3,ORC5,SSNA1,CENPE,CASC5,PSME3,NCAPG2,YWHAH,WRAP53,BTRC,POLA2,FBXW11,ENSA,KIF2C,MCM4,RAB8A,PSMB8,PCNA,FZR1,CEP78,ANAPC10,HIST1H2AJ,TMPO,CENPA,HIST2H2AA4,CDK4,PHF8,SYCE2,HIST1H2BK,RRM2,CDC6,CDK1,TP53BP1,PSMB2,AJUBA,RNF168,CHEK2,PSMC5,VRK1,PSMC1,PPP2R5D,DCTN3,PSMB5,MCM6,PPP1R12A,CENPF,PSMD7,LIG1,CHEK1,HIST1H2BC,NUP205,CEP164,NUP88,CCP110,CEP290,ATR,KNTC1,PSMA5,ORC2,PSMA1,HIST1H4L,MASTL,PCM1,CDC27,ODF2,SDCCAG8,PPP1R12B,NUP62,YWHAZ,CCNB2,POLD2,AKAP9,DYNLL1,E2F5,TP53,ESCO2,PPP2R5B,ORC1,LPIN3,POLD1,LIN54,PSMA6,NUP133,PPP2R1A,PLK4,HIST1H2BD,SKA2,CDC20,PSMB7,YWHAQ,NEDD1,NUP155,NUP214,CDC25C,RANBP2,RUVBL1,RBL1,UBE2V2,PSMD3,MCM8,VRK2,RFC1,CLASP2,ARPP19,PSMD6,SGOL1,CNEP1R1,CDKN2B,DYNC1I2,MCM10,ESCO1,HIST1H4E,RAE1,DCTN2,RAD9B,NUP54,CDCA8,CDK11B,NCAPG,TUBGCP2,HIST1H4D,FBXO5,TOP2A,SGOL2,KMT5A,HIST2H3D,CKS1B,PSMD11,CENPM,HSP90AA1,ORC3,GINS1,PSMB4,PSMC3IP,TOP3A,SKP2,HIST1H4J,POLD3,BORA,CENPP,HIST1H2AE,BIRC5,SPC24,CEP192,UBE2C,CDC14A
R-HSA-69278	Cell Cycle, Mitotic	2.59636353830134e-32	-72.7286111489055	477	251	0.110281195079086	2276	8202	23649,23291,3015,23511,2029,8350,11004,7531,79003,8365,4173,1069,7465,9183,4218,5111,5707,5696,51343,84131,10393,8379,9972,1021,8331,7112,8615,7311,1058,723790,1454,23133,1019,85236,6241,3021,990,9212,8340,79959,4171,5982,983,84296,4926,11190,5719,25936,6233,5714,91754,84962,5690,5527,5705,128312,1870,7443,5700,5528,8086,55957,22995,11258,51433,5689,4175,5693,4659,1063,5713,3978,5715,8347,23165,129401,4000,22897,4927,2010,9738,80184,4174,4609,81876,9735,57804,10426,5686,993,4999,10274,10112,5422,5702,5682,22994,8368,5691,84930,1859,5108,5000,996,2801,23592,4957,10806,8481,4660,23636,9133,9818,5425,1029,10142,80321,10383,8655,1875,9232,157570,1460,5526,4998,64900,5566,5424,132660,25836,9918,595,5687,890,4001,55746,5518,8364,10733,1027,51434,1032,3017,2237,1639,23141,5984,5983,902,348235,991,1871,5695,701,9631,121441,6232,8697,5861,995,8021,7532,79682,3796,8318,5903,5529,8362,7514,79980,5933,5709,4085,84515,8243,7444,3014,5500,5981,23122,10776,9861,151648,255919,203068,4172,1030,6396,1781,114799,55388,8367,8480,10540,53371,55143,984,64151,4176,55055,9491,10844,8360,91687,79172,26271,9702,7153,6118,151246,55835,387893,85378,653604,1163,5717,3320,79019,23595,29781,7314,10051,10726,5694,9837,11130,5692,140609,55755,6502,29882,8363,5710,10714,79866,7316,401541,3012,23310,332,5001,147841,8636,1062,55125,57082,10197,54892,11065,8556,8945	POLA2,FBXW11,H2AFZ,NUP188,ENSA,HIST1H3A,KIF2C,YWHAE,MIS12,HIST1H4H,MCM4,CETN2,WEE1,ZW10,RAB8A,PCNA,PSMD1,PSMB8,FZR1,CEP78,ANAPC10,MAD1L1,NUP153,CDK6,HIST1H2AJ,TMPO,USO1,UBA52,CENPA,HIST2H2AA4,CSNK1E,PHF8,CDK4,HIST1H2BK,RRM2,H3F3B,CDC6,AURKB,HIST1H2BL,CEP76,MCM2,RFC2,CDK1,GINS4,NUMA1,CEP250,PSMD13,NSL1,RPS27A,PSMD8,NEK9,AJUBA,PSMB2,PPP2R5C,PSMC5,HIST3H2BB,E2F2,VRK1,PSMC1,PPP2R5D,AAAS,LIN37,CEP152,DCTN3,ANAPC5,PSMB1,MCM6,PSMB5,PPP1R12A,CENPF,PSMD7,LIG1,PSMD9,HIST1H2BC,NUP205,NUP35,LMNA,CEP164,NUP88,EMD,CCP110,CEP290,MCM5,MYC,RAB1B,KNTC1,POLD4,TUBGCP3,PSMA5,CDC25A,ORC2,STAG1,KIF20A,POLA1,PSMC3,PSMA1,CEP131,HIST1H4L,PSMB3,MASTL,DYRK1A,PCM1,ORC4,CDC27,GOLGA2,LEMD3,ODF2,SDCCAG8,OFD1,PPP1R12B,NUP62,CCNB2,NUP58,POLD2,CDKN2A,AKAP9,CEP70,TUBB4B,DYNLL1,E2F5,PTTG1,ESCO2,CSNK2B,PPP2R5B,ORC1,LPIN3,PRKACA,POLD1,LIN54,NIPBL,NCAPD2,CCND1,PSMA6,CCNA2,LMNB1,NUP133,PPP2R1A,HIST1H4C,PLK4,CDKN1B,ANAPC7,CDKN2D,HIST1H2BD,FEN1,DCTN1,ANKLE2,RFC4,RFC3,CCNH,SKA2,CDC20,E2F3,PSMB7,BUB1B,NUP155,NEDD1,RPS27,CDC23,RAB1A,CDC25C,NUP214,YWHAG,CENPU,KIF2A,CDC45,RANBP2,PPP2R5E,HIST1H4K,XPO1,DSN1,RBL1,PSMD3,MAD2L1,MCM8,SMC1A,VRK2,H2AFX,PPP1CB,RFC1,CLASP2,ARPP19,PSMD6,SGOL1,CNEP1R1,TUBB,MCM3,CDKN2B,SEC13,DYNC1I2,ESCO1,MCM10,HIST1H4E,RAE1,DCTN2,NUP54,CDCA8,CDK11B,NCAPG,MCM7,ZWILCH,PSMF1,TUBGCP2,HIST1H4D,CENPL,CENPO,FBXO5,CEP57,TOP2A,RPA2,SGOL2,CENPJ,KMT5A,TUBGCP6,HIST2H3D,CKS1B,PSMD11,HSP90AA1,CENPM,ORC3,NCAPH2,UBB,SMC4,NUDC,PSMB6,GINS1,ZWINT,PSMB4,NEK7,CDK5RAP2,SKP2,ANAPC2,HIST1H4J,PSMD4,POLD3,BORA,UBC,CENPP,HIST1H2AE,NCAPD3,BIRC5,ORC5,SPC24,SSNA1,CENPE,CEP192,CASC5,PSME3,NCAPG2,UBE2C,CDC14A,BTRC
R-HSA-72766	Translation	1.71364729216994e-26	-59.3285883993763	146	102	0.0448154657293497	2276	8202	6181,8664,1964,6235,6193,6156,1933,6135,6147,6217,6134,6194,6185,2107,6168,6227,8665,6222,1983,1977,6207,6731,6159,6133,11224,7311,6734,6160,6169,6142,6232,4736,6203,8666,8661,3921,8667,6167,27335,1650,6233,6201,6208,1967,9045,6173,6747,2197,6146,8662,8891,6188,6231,6224,6202,6122,6209,23480,6138,6748,6728,1915,6125,23521,6137,6184,8894,9349,1938,6139,6205,6170,6155,6729,6143,26986,1936,6154,8893,1975,6144,1974,6171,6128,6132,6229,6746,1973,9669,25873,6189,6130,6726,6161,6158,6210,1968,6223,8892,6206,6152,60559	RPLP2,EIF3D,EIF1AX,RPS29,RPS5,RPL30,EEF1B2,RPL11,RPL23A,RPS16,RPL10,RPS6,RPN2,ETF1,RPL37A,RPS21,EIF3F,RPS18,EIF5,EIF4E,RPS13,SRP72,RPL29,RPL9,RPL35,UBA52,SRPR,RPL31,RPL38,RPL18A,RPS27,RPL10A,RPS9,EIF3G,EIF3A,RPSA,EIF3H,RPL37,EIF3K,DDOST,RPS27A,RPS7,RPS14,EIF2B1,RPL14,RPL36A,SSR3,FAU,RPL22,EIF3B,EIF2B3,RPS3,RPS26,RPS20,RPS8,RPL3,RPS15,SEC61G,RPL15,SSR4,SRP19,EEF1A1,RPL5,RPL13A,RPL13,RPN1,EIF2S2,RPL23,EEF2,RPL17,RPS11,RPL39,RPL27,SRP54,RPL19,PABPC1,EEF1D,RPL26,EIF2B5,EIF4B,RPL21,EIF4A2,RPL41,RPL6,RPL8,RPS24,SSR2,EIF4A1,EIF5B,RPL36,RPS3A,RPL7A,SRP9,RPL32,RPL28,RPS15A,EIF2S3,RPS19,EIF2B2,RPS12,RPL24,SPCS3
R-HSA-72737	Cap-dependent Translation Initiation	1.80906017115226e-25	-56.9718198568838	112	84	0.0369068541300527	2276	8202	6181,8664,1964,6235,6193,6156,6135,6147,6217,6134,6194,6168,6227,8665,6222,1983,1977,6207,6159,6133,7311,11224,6160,6169,6142,6232,4736,6203,8666,8661,3921,8667,6167,27335,6201,6233,6208,1967,9045,6173,2197,6146,8662,8891,6188,6231,6202,6122,6224,6209,6138,6125,23521,6137,8894,9349,6139,6205,6170,6155,6143,26986,6154,8893,1975,6144,1974,6171,6128,6132,6229,1973,9669,25873,6189,6130,6161,6158,6210,1968,6223,8892,6206,6152	RPLP2,EIF3D,EIF1AX,RPS29,RPS5,RPL30,RPL11,RPL23A,RPS16,RPL10,RPS6,RPL37A,RPS21,EIF3F,RPS18,EIF5,EIF4E,RPS13,RPL29,RPL9,UBA52,RPL35,RPL31,RPL38,RPL18A,RPS27,RPL10A,RPS9,EIF3G,EIF3A,RPSA,EIF3H,RPL37,EIF3K,RPS7,RPS27A,RPS14,EIF2B1,RPL14,RPL36A,FAU,RPL22,EIF3B,EIF2B3,RPS3,RPS26,RPS8,RPL3,RPS20,RPS15,RPL15,RPL5,RPL13A,RPL13,EIF2S2,RPL23,RPL17,RPS11,RPL39,RPL27,RPL19,PABPC1,RPL26,EIF2B5,EIF4B,RPL21,EIF4A2,RPL41,RPL6,RPL8,RPS24,EIF4A1,EIF5B,RPL36,RPS3A,RPL7A,RPL32,RPL28,RPS15A,EIF2S3,RPS19,EIF2B2,RPS12,RPL24
R-HSA-72613	Eukaryotic Translation Initiation	1.80906017115226e-25	-56.9718198568838	112	84	0.0369068541300527	2276	8202	6181,8664,1964,6235,6193,6156,6135,6147,6217,6134,6194,6168,6227,8665,6222,1983,1977,6207,6159,6133,7311,11224,6160,6169,6142,6232,4736,6203,8666,8661,3921,8667,6167,27335,6201,6233,6208,1967,9045,6173,2197,6146,8662,8891,6188,6231,6202,6122,6224,6209,6138,6125,23521,6137,8894,9349,6139,6205,6170,6155,6143,26986,6154,8893,1975,6144,1974,6171,6128,6132,6229,1973,9669,25873,6189,6130,6161,6158,6210,1968,6223,8892,6206,6152	RPLP2,EIF3D,EIF1AX,RPS29,RPS5,RPL30,RPL11,RPL23A,RPS16,RPL10,RPS6,RPL37A,RPS21,EIF3F,RPS18,EIF5,EIF4E,RPS13,RPL29,RPL9,UBA52,RPL35,RPL31,RPL38,RPL18A,RPS27,RPL10A,RPS9,EIF3G,EIF3A,RPSA,EIF3H,RPL37,EIF3K,RPS7,RPS27A,RPS14,EIF2B1,RPL14,RPL36A,FAU,RPL22,EIF3B,EIF2B3,RPS3,RPS26,RPS8,RPL3,RPS20,RPS15,RPL15,RPL5,RPL13A,RPL13,EIF2S2,RPL23,RPL17,RPS11,RPL39,RPL27,RPL19,PABPC1,RPL26,EIF2B5,EIF4B,RPL21,EIF4A2,RPL41,RPL6,RPL8,RPS24,EIF4A1,EIF5B,RPL36,RPS3A,RPL7A,RPL32,RPL28,RPS15A,EIF2S3,RPS19,EIF2B2,RPS12,RPL24
R-HSA-5663205	Infectious disease	9.48623516784327e-25	-55.3147855066591	347	185	0.0812829525483304	2276	8202	23511,2071,4869,5606,6147,805,5696,6217,5707,6134,6843,6194,8907,163,6168,6227,9972,6917,6882,6222,6133,7311,3841,8731,6160,4736,6167,5432,5719,6233,5714,6208,9045,5690,7251,5705,6188,5700,6231,8086,4836,6209,5689,6884,5693,6872,5440,51534,5713,6138,3978,23327,5715,6125,23165,23521,129401,811,6137,8178,4927,9349,1938,6205,6170,2965,2960,51606,5431,5686,6154,5702,6128,5682,6229,6921,6616,7469,6875,6829,84168,5691,7520,25873,6130,6158,160,6223,5434,23636,9818,27243,6181,6235,5604,6193,6156,821,162,6135,5687,2968,55746,2237,6207,6881,6159,6877,11224,902,3326,5695,6169,9525,6142,6232,9631,2958,25978,8021,6203,3921,11198,6873,5903,7514,6201,5709,2547,6173,9861,6146,2197,1175,6202,6122,6224,9150,6908,8480,53371,567,9491,5478,3105,2962,6139,83860,6155,2963,5717,6143,2068,3320,7314,2959,3837,5694,7296,5609,5692,7936,6144,6171,6132,51652,5710,5430,7316,3304,6189,4686,3840,6161,6210,5608,79720,6206,6152,3159,6883,10197,164,6878,8945	NUP188,ERCC3,NPM1,MAP2K3,RPL23A,CALM2,PSMB8,RPS16,PSMD1,RPL10,VAMP1,RPS6,AP1M1,AP2B1,RPL37A,RPS21,NUP153,TCEA1,TAF11,RPS18,RPL9,UBA52,KPNA5,RNMT,RPL31,RPL10A,RPL37,POLR2C,PSMD13,RPS27A,PSMD8,RPS14,RPL14,PSMB2,TSG101,PSMC5,RPS3,PSMC1,RPS26,AAAS,NMT1,RPS15,PSMB1,TAF13,PSMB5,TAF1,POLR2K,VTA1,PSMD7,RPL15,LIG1,NEDD4L,PSMD9,RPL5,NUP205,RPL13A,NUP35,CALR,RPL13,ELL,NUP88,RPL23,EEF2,RPS11,RPL39,GTF2H1,GTF2E1,ATP6V1H,POLR2B,PSMA5,RPL26,PSMC3,RPL6,PSMA1,RPS24,TCEB1,SNAP25,NELFA,TAF4B,SUPT5H,ANTXR1,PSMB3,XRCC5,RPL36,RPL7A,RPL28,AP2A1,RPS19,POLR2E,NUP62,NUP58,CHMP2A,RPLP2,RPS29,MAP2K1,RPS5,RPL30,CANX,AP1B1,RPL11,PSMA6,GTF2H4,NUP133,FEN1,RPS13,TAF10,RPL29,TAF5,RPL35,CCNH,HSP90AB1,PSMB7,RPL38,VPS4B,RPL18A,RPS27,NUP155,GTF2A2,CHMP2B,NUP214,RPS9,RPSA,SUPT16H,TAF2,RANBP2,XPO1,RPS7,PSMD3,XRCC6,RPL36A,PSMD6,RPL22,FAU,AP2S1,RPS8,RPL3,RPS20,CTDP1,TBP,RAE1,NUP54,B2M,PSMF1,PPIA,HLA-A,GTF2F1,RPL17,TAF3,RPL27,GTF2F2,PSMD11,RPL19,ERCC2,HSP90AA1,UBB,GTF2B,KPNB1,PSMB6,TXNRD1,MAP2K7,PSMB4,NELFE,RPL21,RPL41,RPL8,CHMP3,PSMD4,POLR2A,UBC,HSPA1B,RPS3A,NCBP1,KPNA4,RPL32,RPS15A,MAP2K6,VPS37B,RPS12,RPL24,HMGA1,TAF12,PSME3,AP1G1,TAF6,BTRC
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	3.5552948518097e-24	-53.9936042320104	105	79	0.0347100175746924	2276	8202	6181,8664,1964,6235,6193,6156,6135,6147,6217,6134,6194,6168,6227,8665,6222,1983,1977,6207,6159,6133,7311,11224,6160,6169,6142,6232,4736,6203,8666,8661,8667,3921,6167,27335,6201,6233,6208,9045,6173,2197,6146,8662,6188,6231,6202,6122,6224,6209,6138,6125,23521,6137,8894,9349,6139,6205,6170,6155,6143,6154,1975,1974,6144,6171,6128,6132,6229,1973,9669,25873,6189,6130,6158,6210,6161,1968,6223,6206,6152	RPLP2,EIF3D,EIF1AX,RPS29,RPS5,RPL30,RPL11,RPL23A,RPS16,RPL10,RPS6,RPL37A,RPS21,EIF3F,RPS18,EIF5,EIF4E,RPS13,RPL29,RPL9,UBA52,RPL35,RPL31,RPL38,RPL18A,RPS27,RPL10A,RPS9,EIF3G,EIF3A,EIF3H,RPSA,RPL37,EIF3K,RPS7,RPS27A,RPS14,RPL14,RPL36A,FAU,RPL22,EIF3B,RPS3,RPS26,RPS8,RPL3,RPS20,RPS15,RPL15,RPL5,RPL13A,RPL13,EIF2S2,RPL23,RPL17,RPS11,RPL39,RPL27,RPL19,RPL26,EIF4B,EIF4A2,RPL21,RPL41,RPL6,RPL8,RPS24,EIF4A1,EIF5B,RPL36,RPS3A,RPL7A,RPL28,RPS15A,RPL32,EIF2S3,RPS19,RPS12,RPL24
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	9.87268033486591e-24	-52.9722708514623	104	78	0.0342706502636204	2276	8202	6181,8664,1964,6235,6193,6156,6135,6147,6217,6134,6194,6168,6227,8665,6222,1977,6207,6159,6133,7311,11224,6160,6169,6142,6232,4736,6203,8666,8661,8667,3921,6167,27335,6201,6233,6208,9045,6173,2197,6146,8662,6188,6231,6202,6122,6224,6209,6138,6125,23521,6137,8894,9349,6139,6205,6170,6155,6143,26986,6154,1975,1974,6144,6171,6128,6132,6229,1973,25873,6189,6130,6158,6210,6161,1968,6223,6206,6152	RPLP2,EIF3D,EIF1AX,RPS29,RPS5,RPL30,RPL11,RPL23A,RPS16,RPL10,RPS6,RPL37A,RPS21,EIF3F,RPS18,EIF4E,RPS13,RPL29,RPL9,UBA52,RPL35,RPL31,RPL38,RPL18A,RPS27,RPL10A,RPS9,EIF3G,EIF3A,EIF3H,RPSA,RPL37,EIF3K,RPS7,RPS27A,RPS14,RPL14,RPL36A,FAU,RPL22,EIF3B,RPS3,RPS26,RPS8,RPL3,RPS20,RPS15,RPL15,RPL5,RPL13A,RPL13,EIF2S2,RPL23,RPL17,RPS11,RPL39,RPL27,RPL19,PABPC1,RPL26,EIF4B,EIF4A2,RPL21,RPL41,RPL6,RPL8,RPS24,EIF4A1,RPL36,RPS3A,RPL7A,RPL28,RPS15A,RPL32,EIF2S3,RPS19,RPS12,RPL24
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	1.57819792185191e-22	-50.2005884055488	153	100	0.0439367311072056	2276	8202	55599,23511,9939,10978,6635,5093,220988,83443,10992,3181,10286,55746,57721,6429,3191,9972,51692,3192,1977,55749,5094,10291,1477,27339,988,11338,4809,23020,6629,5725,3312,3185,3183,10921,7884,9631,51585,11100,10907,8021,10421,6426,55954,5432,5903,11051,10236,7307,8243,9128,2521,6637,8086,9785,6627,3178,10594,5440,6431,8480,10250,53371,10946,10949,10482,3187,10081,56339,23165,129401,2962,4927,56259,10189,9343,2963,3184,4904,24148,5431,51639,9589,6430,8175,6626,5430,23450,9416,4686,3188,27316,5434,1478,3190,23636,11066,6428,6633,9818,51503	RNPC3,NUP188,RBM8A,CLP1,SNRPE,PCBP1,HNRNPA3,SF3B5,SF3B2,HNRNPA2B1,BCAS2,NUP133,METTL14,SRSF4,HNRNPL,NUP153,CPSF3,HNRNPU,EIF4E,CCAR1,PCBP2,SF3A1,CSTF1,PRPF19,CDC5L,U2AF2,SNU13,SNRNP200,SNRPB2,PTBP1,HSPA8,HNRNPF,HNRNPC,RNPS1,SLBP,NUP155,PCF11,HNRNPUL1,TXNL4A,NUP214,CD2BP2,SRSF1,ZMAT5,POLR2C,RANBP2,NUDT21,HNRNPR,U2AF1,SMC1A,PRPF4,FUS,SNRPG,AAAS,DHX38,SNRPA1,HNRNPA1,PRPF8,POLR2K,SRSF6,RAE1,SRRM1,NUP54,SF3A3,HNRNPA0,NXF1,HNRNPH1,PDCD7,METTL3,NUP205,NUP35,GTF2F1,NUP88,CTNNBL1,ALYREF,EFTUD2,GTF2F2,HNRNPD,YBX1,PRPF6,POLR2B,SF3B6,WTAP,SRSF5,SF3A2,SNRPA,POLR2A,SF3B3,DDX23,NCBP1,HNRNPH2,RBMX,POLR2E,CSTF2,HNRNPK,NUP62,SNRNP35,SRSF3,SNRPD2,NUP58,CWC15
R-HSA-72689	Formation of a pool of free 40S subunits	5.10330836137872e-22	-49.026983018143	94	71	0.031195079086116	2276	8202	6181,8664,1964,6235,6193,6156,6135,6147,6217,6134,6194,6227,8665,6168,6222,6207,6159,6133,7311,11224,6160,6169,6142,6232,4736,6203,8666,8661,8667,3921,6167,27335,6201,6233,6208,9045,6173,6188,8662,6146,2197,6231,6202,6122,6224,6209,6138,6125,23521,6137,9349,6139,6170,6205,6155,6143,6154,6144,6171,6132,6128,6229,6189,25873,6130,6158,6210,6161,6223,6206,6152	RPLP2,EIF3D,EIF1AX,RPS29,RPS5,RPL30,RPL11,RPL23A,RPS16,RPL10,RPS6,RPS21,EIF3F,RPL37A,RPS18,RPS13,RPL29,RPL9,UBA52,RPL35,RPL31,RPL38,RPL18A,RPS27,RPL10A,RPS9,EIF3G,EIF3A,EIF3H,RPSA,RPL37,EIF3K,RPS7,RPS27A,RPS14,RPL14,RPL36A,RPS3,EIF3B,RPL22,FAU,RPS26,RPS8,RPL3,RPS20,RPS15,RPL15,RPL5,RPL13A,RPL13,RPL23,RPL17,RPL39,RPS11,RPL27,RPL19,RPL26,RPL21,RPL41,RPL8,RPL6,RPS24,RPS3A,RPL36,RPL7A,RPL28,RPS15A,RPL32,RPS19,RPS12,RPL24
R-HSA-156902	Peptide chain elongation	2.94730745087982e-21	-47.2733949278288	84	65	0.0285588752196837	2276	8202	6181,6235,6193,6156,6135,6147,6217,6134,6194,6227,6168,6222,6207,6159,6133,7311,11224,6160,6169,6142,6232,4736,6203,3921,6167,6201,6233,6208,9045,6173,6188,6146,2197,6231,6202,6122,6224,6209,6138,6125,1915,23521,6137,9349,1938,6139,6170,6205,6155,6143,6154,6144,6132,6128,6171,6229,6189,25873,6130,6210,6158,6161,6223,6206,6152	RPLP2,RPS29,RPS5,RPL30,RPL11,RPL23A,RPS16,RPL10,RPS6,RPS21,RPL37A,RPS18,RPS13,RPL29,RPL9,UBA52,RPL35,RPL31,RPL38,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL37,RPS7,RPS27A,RPS14,RPL14,RPL36A,RPS3,RPL22,FAU,RPS26,RPS8,RPL3,RPS20,RPS15,RPL15,RPL5,EEF1A1,RPL13A,RPL13,RPL23,EEF2,RPL17,RPL39,RPS11,RPL27,RPL19,RPL26,RPL21,RPL8,RPL6,RPL41,RPS24,RPS3A,RPL36,RPL7A,RPS15A,RPL28,RPL32,RPS19,RPS12,RPL24
R-HSA-156842	Eukaryotic Translation Elongation	3.51893223055832e-21	-47.0961293528743	88	67	0.0294376098418278	2276	8202	6181,6235,6193,6156,1933,6135,6147,6217,6134,6194,6227,6168,6222,6207,6159,6133,7311,11224,6160,6169,6142,6232,4736,6203,3921,6167,6201,6233,6208,9045,6173,6188,6146,2197,6231,6202,6122,6224,6209,6138,6125,1915,23521,6137,9349,1938,6139,6170,6205,6155,6143,1936,6154,6144,6171,6132,6128,6229,6189,25873,6130,6210,6158,6161,6223,6206,6152	RPLP2,RPS29,RPS5,RPL30,EEF1B2,RPL11,RPL23A,RPS16,RPL10,RPS6,RPS21,RPL37A,RPS18,RPS13,RPL29,RPL9,UBA52,RPL35,RPL31,RPL38,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL37,RPS7,RPS27A,RPS14,RPL14,RPL36A,RPS3,RPL22,FAU,RPS26,RPS8,RPL3,RPS20,RPS15,RPL15,RPL5,EEF1A1,RPL13A,RPL13,RPL23,EEF2,RPL17,RPL39,RPS11,RPL27,RPL19,EEF1D,RPL26,RPL21,RPL41,RPL8,RPL6,RPS24,RPS3A,RPL36,RPL7A,RPS15A,RPL28,RPL32,RPS19,RPS12,RPL24
R-HSA-168255	Influenza Life Cycle	6.00139745571352e-21	-46.5622946014805	136	90	0.0395430579964851	2276	8202	23511,6181,6235,6193,6156,821,6135,6147,6217,6134,55746,6194,6227,9972,6168,6222,6207,6159,6133,7311,11224,6160,6169,6142,6232,9631,4736,8021,6203,3921,6167,5432,5903,7514,6201,6233,6208,9045,6173,2197,6188,6146,6231,8086,6202,6122,6224,6209,5440,8480,53371,6138,6125,23165,129401,23521,2962,6137,811,4927,9349,6139,6205,6170,6155,2963,6143,3320,5431,3837,6154,6144,6171,6128,6132,6229,5430,3304,25873,6189,6130,6161,6158,6210,5434,6223,23636,6206,6152,9818	NUP188,RPLP2,RPS29,RPS5,RPL30,CANX,RPL11,RPL23A,RPS16,RPL10,NUP133,RPS6,RPS21,NUP153,RPL37A,RPS18,RPS13,RPL29,RPL9,UBA52,RPL35,RPL31,RPL38,RPL18A,RPS27,NUP155,RPL10A,NUP214,RPS9,RPSA,RPL37,POLR2C,RANBP2,XPO1,RPS7,RPS27A,RPS14,RPL14,RPL36A,FAU,RPS3,RPL22,RPS26,AAAS,RPS8,RPL3,RPS20,RPS15,POLR2K,RAE1,NUP54,RPL15,RPL5,NUP205,NUP35,RPL13A,GTF2F1,RPL13,CALR,NUP88,RPL23,RPL17,RPS11,RPL39,RPL27,GTF2F2,RPL19,HSP90AA1,POLR2B,KPNB1,RPL26,RPL21,RPL41,RPL6,RPL8,RPS24,POLR2A,HSPA1B,RPL36,RPS3A,RPL7A,RPL32,RPL28,RPS15A,POLR2E,RPS19,NUP62,RPS12,RPL24,NUP58
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	9.93397240583817e-21	-46.058326513943	107	76	0.0333919156414763	2276	8202	6181,6235,6193,6156,6135,6147,6217,6134,6194,6185,6227,6168,6222,6207,6731,6159,6133,7311,11224,6734,6160,6169,6142,6232,4736,6203,3921,6167,1650,6201,6233,6208,9045,6173,6747,6188,6146,2197,6231,6202,6122,6224,6209,23480,6138,6748,6728,6125,23521,6137,6184,9349,6139,6170,6205,6155,6729,6143,6154,6144,6171,6128,6132,6746,6229,6189,25873,6130,6726,6158,6210,6161,6223,6206,60559,6152	RPLP2,RPS29,RPS5,RPL30,RPL11,RPL23A,RPS16,RPL10,RPS6,RPN2,RPS21,RPL37A,RPS18,RPS13,SRP72,RPL29,RPL9,UBA52,RPL35,SRPR,RPL31,RPL38,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL37,DDOST,RPS7,RPS27A,RPS14,RPL14,RPL36A,SSR3,RPS3,RPL22,FAU,RPS26,RPS8,RPL3,RPS20,RPS15,SEC61G,RPL15,SSR4,SRP19,RPL5,RPL13A,RPL13,RPN1,RPL23,RPL17,RPL39,RPS11,RPL27,SRP54,RPL19,RPL26,RPL21,RPL41,RPL6,RPL8,SSR2,RPS24,RPS3A,RPL36,RPL7A,SRP9,RPL28,RPS15A,RPL32,RPS19,RPS12,SPCS3,RPL24
R-HSA-168273	Influenza Viral RNA Transcription and Replication	2.44622539241545e-20	-45.1571556795123	127	85	0.0373462214411248	2276	8202	23511,6181,6235,6193,6156,6135,6147,6217,6134,55746,6194,6227,9972,6168,6222,6207,6159,6133,7311,11224,6160,6169,6142,6232,9631,4736,8021,6203,3921,6167,5432,5903,6201,6233,6208,9045,6173,2197,6188,6146,6231,8086,6202,6122,6224,6209,5440,8480,53371,6138,6125,23165,129401,23521,2962,6137,4927,9349,6139,6205,6170,6155,2963,6143,3320,5431,6154,6144,6171,6128,6132,6229,5430,25873,6189,6130,6158,6210,6161,5434,6223,23636,6206,6152,9818	NUP188,RPLP2,RPS29,RPS5,RPL30,RPL11,RPL23A,RPS16,RPL10,NUP133,RPS6,RPS21,NUP153,RPL37A,RPS18,RPS13,RPL29,RPL9,UBA52,RPL35,RPL31,RPL38,RPL18A,RPS27,NUP155,RPL10A,NUP214,RPS9,RPSA,RPL37,POLR2C,RANBP2,RPS7,RPS27A,RPS14,RPL14,RPL36A,FAU,RPS3,RPL22,RPS26,AAAS,RPS8,RPL3,RPS20,RPS15,POLR2K,RAE1,NUP54,RPL15,RPL5,NUP205,NUP35,RPL13A,GTF2F1,RPL13,NUP88,RPL23,RPL17,RPS11,RPL39,RPL27,GTF2F2,RPL19,HSP90AA1,POLR2B,RPL26,RPL21,RPL41,RPL6,RPL8,RPS24,POLR2A,RPL36,RPS3A,RPL7A,RPL28,RPS15A,RPL32,POLR2E,RPS19,NUP62,RPS12,RPL24,NUP58
R-HSA-72764	Eukaryotic Translation Termination	7.6446051770463e-20	-44.0177016664318	85	64	0.0281195079086116	2276	8202	6181,6235,6193,6156,6135,6147,6217,6134,6194,2107,6227,6168,6222,6207,6159,6133,7311,11224,6160,6169,6142,6232,4736,6203,3921,6167,6201,6233,6208,9045,6173,6188,6146,2197,6231,6202,6122,6224,6209,6138,6125,23521,6137,9349,6139,6170,6205,6155,6143,6154,6144,6132,6128,6171,6229,6189,25873,6130,6210,6158,6161,6223,6152,6206	RPLP2,RPS29,RPS5,RPL30,RPL11,RPL23A,RPS16,RPL10,RPS6,ETF1,RPS21,RPL37A,RPS18,RPS13,RPL29,RPL9,UBA52,RPL35,RPL31,RPL38,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL37,RPS7,RPS27A,RPS14,RPL14,RPL36A,RPS3,RPL22,FAU,RPS26,RPS8,RPL3,RPS20,RPS15,RPL15,RPL5,RPL13A,RPL13,RPL23,RPL17,RPL39,RPS11,RPL27,RPL19,RPL26,RPL21,RPL8,RPL6,RPL41,RPS24,RPS3A,RPL36,RPL7A,RPS15A,RPL28,RPL32,RPS19,RPL24,RPS12
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	8.18094267537506e-20	-43.9498944744177	89	66	0.0289982425307557	2276	8202	6181,6235,6193,6156,6135,6147,6217,6134,6194,2107,6227,6168,6222,6207,6159,6133,7311,11224,6160,6169,6142,6232,4736,6203,3921,6167,6201,6233,6208,9045,6173,2197,6188,6146,6231,6202,6122,6224,6209,6138,6125,23521,6137,9349,6139,6205,6170,6155,6143,26986,6154,6144,6132,6171,6128,6229,6189,25873,6130,4686,6210,6158,6161,6223,6152,6206	RPLP2,RPS29,RPS5,RPL30,RPL11,RPL23A,RPS16,RPL10,RPS6,ETF1,RPS21,RPL37A,RPS18,RPS13,RPL29,RPL9,UBA52,RPL35,RPL31,RPL38,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL37,RPS7,RPS27A,RPS14,RPL14,RPL36A,FAU,RPS3,RPL22,RPS26,RPS8,RPL3,RPS20,RPS15,RPL15,RPL5,RPL13A,RPL13,RPL23,RPL17,RPS11,RPL39,RPL27,RPL19,PABPC1,RPL26,RPL21,RPL8,RPL41,RPL6,RPS24,RPS3A,RPL36,RPL7A,NCBP1,RPS15A,RPL28,RPL32,RPS19,RPL24,RPS12
R-HSA-192823	Viral mRNA Translation	2.11605148628127e-19	-42.9995649212959	84	63	0.0276801405975395	2276	8202	6224,6122,6202,6209,6181,6235,6193,6138,6156,6125,23521,6135,6147,6137,6217,9349,6134,6139,6205,6170,6155,6194,6143,6227,6168,6222,6207,6154,6159,6133,7311,11224,6160,6144,6171,6128,6132,6169,6229,6142,6232,4736,6203,3921,25873,6189,6130,6167,6161,6158,6210,6201,6233,6208,6223,9045,6173,6206,6152,6188,6146,2197,6231	RPS20,RPL3,RPS8,RPS15,RPLP2,RPS29,RPS5,RPL15,RPL30,RPL5,RPL13A,RPL11,RPL23A,RPL13,RPS16,RPL23,RPL10,RPL17,RPS11,RPL39,RPL27,RPS6,RPL19,RPS21,RPL37A,RPS18,RPS13,RPL26,RPL29,RPL9,UBA52,RPL35,RPL31,RPL21,RPL41,RPL6,RPL8,RPL38,RPS24,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL36,RPS3A,RPL7A,RPL37,RPL32,RPL28,RPS15A,RPS7,RPS27A,RPS14,RPS19,RPL14,RPL36A,RPS12,RPL24,RPS3,RPL22,FAU,RPS26
R-HSA-72172	mRNA Splicing	4.70986764937933e-19	-42.1994569591728	120	80	0.0351493848857645	2276	8202	55599,9939,10978,6635,5093,220988,83443,10992,3181,10286,6429,3191,51692,3192,55749,5094,10291,1477,27339,988,11338,4809,23020,6629,5725,3312,3185,3183,10921,51585,11100,10907,10421,6426,55954,5432,11051,10236,7307,8243,9128,2521,6637,9785,6627,3178,10594,5440,6431,10250,10949,10946,3187,10081,2962,56259,10189,9343,2963,3184,4904,24148,5431,51639,6430,8175,6626,5430,23450,9416,4686,3188,27316,5434,1478,3190,11066,6428,6633,51503	RNPC3,RBM8A,CLP1,SNRPE,PCBP1,HNRNPA3,SF3B5,SF3B2,HNRNPA2B1,BCAS2,SRSF4,HNRNPL,CPSF3,HNRNPU,CCAR1,PCBP2,SF3A1,CSTF1,PRPF19,CDC5L,U2AF2,SNU13,SNRNP200,SNRPB2,PTBP1,HSPA8,HNRNPF,HNRNPC,RNPS1,PCF11,HNRNPUL1,TXNL4A,CD2BP2,SRSF1,ZMAT5,POLR2C,NUDT21,HNRNPR,U2AF1,SMC1A,PRPF4,FUS,SNRPG,DHX38,SNRPA1,HNRNPA1,PRPF8,POLR2K,SRSF6,SRRM1,HNRNPA0,SF3A3,HNRNPH1,PDCD7,GTF2F1,CTNNBL1,ALYREF,EFTUD2,GTF2F2,HNRNPD,YBX1,PRPF6,POLR2B,SF3B6,SRSF5,SF3A2,SNRPA,POLR2A,SF3B3,DDX23,NCBP1,HNRNPH2,RBMX,POLR2E,CSTF2,HNRNPK,SNRNP35,SRSF3,SNRPD2,CWC15
R-HSA-168254	Influenza Infection	6.51809205522687e-19	-41.8745350633391	147	92	0.0404217926186292	2276	8202	23511,6181,6235,6193,6156,821,6135,6147,6217,6134,55746,6194,6227,9972,6168,6222,6207,6159,6133,7311,11224,3841,6160,6169,6142,6232,9631,4736,8021,6203,3921,6167,5432,5903,7514,6201,6233,6208,9045,6173,2197,6188,6146,6231,8086,6202,6122,6224,6209,5440,8480,53371,6138,6125,23165,129401,23521,2962,6137,811,4927,9349,6139,6205,6170,6155,2963,6143,3320,5431,3837,6154,6144,6171,6128,6132,6229,5430,3304,25873,6189,6130,3840,6161,6158,6210,5434,6223,23636,6206,6152,9818	NUP188,RPLP2,RPS29,RPS5,RPL30,CANX,RPL11,RPL23A,RPS16,RPL10,NUP133,RPS6,RPS21,NUP153,RPL37A,RPS18,RPS13,RPL29,RPL9,UBA52,RPL35,KPNA5,RPL31,RPL38,RPL18A,RPS27,NUP155,RPL10A,NUP214,RPS9,RPSA,RPL37,POLR2C,RANBP2,XPO1,RPS7,RPS27A,RPS14,RPL14,RPL36A,FAU,RPS3,RPL22,RPS26,AAAS,RPS8,RPL3,RPS20,RPS15,POLR2K,RAE1,NUP54,RPL15,RPL5,NUP205,NUP35,RPL13A,GTF2F1,RPL13,CALR,NUP88,RPL23,RPL17,RPS11,RPL39,RPL27,GTF2F2,RPL19,HSP90AA1,POLR2B,KPNB1,RPL26,RPL21,RPL41,RPL6,RPL8,RPS24,POLR2A,HSPA1B,RPL36,RPS3A,RPL7A,KPNA4,RPL32,RPL28,RPS15A,POLR2E,RPS19,NUP62,RPS12,RPL24,NUP58
R-HSA-1852241	Organelle biogenesis and maintenance	1.26888785357707e-18	-41.2083908629215	321	162	0.0711775043936731	2276	8202	26123,261734,64960,5565,10102,3396,54903,26160,79738,7531,10013,9801,10575,1069,4218,116540,84131,55770,23082,64792,51253,2551,1454,129880,6182,79590,5571,54516,79959,983,378,55052,54460,51668,11190,51264,92482,28957,65008,10891,11258,22995,51373,65080,64216,585,54205,9321,4735,27241,2553,22897,83657,9738,80184,90410,63875,55112,51642,51650,9657,112752,219402,54948,122704,22994,10694,166379,51318,132320,85476,51422,5108,9553,79989,4957,10806,57728,60412,51626,8481,6907,2101,11222,29074,5564,83658,10142,80321,10383,54148,8655,51263,89891,55212,5566,8729,79809,54534,9727,23059,5147,5518,10733,6742,9572,1386,1639,3054,10576,91147,51258,4528,60488,121441,4209,63931,11232,7532,84100,51069,6950,51649,128308,118487,200894,55764,9742,146057,51021,54998,203068,57129,1781,28977,7978,10540,64949,65993,506,11020,8766,64963,56945,9702,55835,116541,3320,29088,64951,51134,55755,7284,55173,7203,347240,80173,64979,51081,8636,55125,4867	TCTN3,NPHP4,MRPS15,PRKAB2,TSFM,ICT1,MKS1,IFT172,BBS10,YWHAE,HDAC6,MRPL19,CCT4,CETN2,RAB8A,MRPL53,CEP78,EXOC2,PPRC1,IFT22,MRPL37,GABPA,CSNK1E,BBS5,MRPL12,MRPL24,PRKAG1,MTRF1L,CEP76,CDK1,ARF4,MRPL20,MRPS21,HSPB11,CEP250,MRPL27,BBIP1,MRPS28,MRPL1,PPARGC1A,DCTN3,CEP152,MRPS17,MRPL44,TFB2M,BBS4,CYCS,TRIP11,SEPT2,BBS9,GABPB1,CEP164,DYNLRB2,CCP110,CEP290,IFT20,MRPL17,WDR60,MRPL48,MRPS33,IQCB1,IFT43,MTIF3,MRPL16,MRPL52,CEP131,CCT8,BBS12,MRPL35,SCLT1,GFM1,PRKAG2,PCM1,MRPL33,TTC26,ODF2,SDCCAG8,WDR19,EXOC4,DYNC2LI1,OFD1,TBL1X,ESRRA,MRPL3,MRPL18,PRKAB1,DYNLRB1,AKAP9,CEP70,TUBB4B,MRPL39,DYNLL1,MRPL30,WDR34,BBS7,PRKACA,GBF1,TTC21B,MRPL50,RAB11FIP3,CLUAP1,PDE6D,PPP2R1A,PLK4,SSBP1,NR1D1,ATF2,DCTN1,HCFC1,CCT2,TMEM67,MRPL51,MTIF2,MRPS35,NEDD1,MEF2D,MRPS14,POLG2,YWHAG,ARL6,MRPL2,TCP1,MRPS23,MRPL55,CHCHD1,ARL13B,IFT122,IFT140,TTBK2,MRPS16,AURKAIP1,TUBB,MRPL47,DYNC1I2,MRPL42,MTERF1,DCTN2,MRPS26,MRPS34,ATP5B,IFT27,RAB11A,MRPS11,MRPS22,CEP57,CENPJ,MRPL54,HSP90AA1,MRPL15,MRPS24,CEP83,CDK5RAP2,TUFM,MRPS10,CCT3,KIF24,IFT74,MRPL36,MRPS7,SSNA1,CEP192,NPHP1
R-HSA-72163	mRNA Splicing - Major Pathway	1.66562341968957e-18	-40.9363321943004	113	76	0.0333919156414763	2276	8202	9939,10978,6635,5093,220988,83443,10992,3181,10286,6429,3191,51692,3192,55749,5094,10291,1477,27339,988,11338,4809,23020,6629,5725,3312,3185,3183,10921,51585,11100,10907,10421,6426,5432,11051,10236,7307,8243,9128,2521,6637,9785,6627,3178,10594,5440,6431,10250,10949,10946,3187,2962,56259,10189,9343,2963,3184,4904,24148,5431,51639,6430,8175,6626,5430,9416,23450,4686,3188,27316,5434,1478,3190,6428,6633,51503	RBM8A,CLP1,SNRPE,PCBP1,HNRNPA3,SF3B5,SF3B2,HNRNPA2B1,BCAS2,SRSF4,HNRNPL,CPSF3,HNRNPU,CCAR1,PCBP2,SF3A1,CSTF1,PRPF19,CDC5L,U2AF2,SNU13,SNRNP200,SNRPB2,PTBP1,HSPA8,HNRNPF,HNRNPC,RNPS1,PCF11,HNRNPUL1,TXNL4A,CD2BP2,SRSF1,POLR2C,NUDT21,HNRNPR,U2AF1,SMC1A,PRPF4,FUS,SNRPG,DHX38,SNRPA1,HNRNPA1,PRPF8,POLR2K,SRSF6,SRRM1,HNRNPA0,SF3A3,HNRNPH1,GTF2F1,CTNNBL1,ALYREF,EFTUD2,GTF2F2,HNRNPD,YBX1,PRPF6,POLR2B,SF3B6,SRSF5,SF3A2,SNRPA,POLR2A,DDX23,SF3B3,NCBP1,HNRNPH2,RBMX,POLR2E,CSTF2,HNRNPK,SRSF3,SNRPD2,CWC15
R-HSA-927802	Nonsense-Mediated Decay (NMD)	5.76871741060116e-18	-39.6940819039397	106	72	0.031634446397188	2276	8202	6181,6235,9939,6193,6156,6135,6147,6217,6134,9775,5518,6194,2107,6227,6168,6222,6207,6159,6133,7311,11224,6160,6169,10921,6142,6232,4736,6203,3921,6167,6201,6233,6208,9045,6173,56006,2197,6188,6146,6231,6224,6202,6122,6209,6138,6125,23521,6137,9349,6139,6205,6170,6155,26019,6143,26986,6154,6144,6132,6171,6128,6229,6189,25873,6130,4686,6210,6158,6161,6223,6206,6152	RPLP2,RPS29,RBM8A,RPS5,RPL30,RPL11,RPL23A,RPS16,RPL10,EIF4A3,PPP2R1A,RPS6,ETF1,RPS21,RPL37A,RPS18,RPS13,RPL29,RPL9,UBA52,RPL35,RPL31,RPL38,RNPS1,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL37,RPS7,RPS27A,RPS14,RPL14,RPL36A,SMG9,FAU,RPS3,RPL22,RPS26,RPS20,RPS8,RPL3,RPS15,RPL15,RPL5,RPL13A,RPL13,RPL23,RPL17,RPS11,RPL39,RPL27,UPF2,RPL19,PABPC1,RPL26,RPL21,RPL8,RPL41,RPL6,RPS24,RPS3A,RPL36,RPL7A,NCBP1,RPS15A,RPL28,RPL32,RPS19,RPS12,RPL24
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	5.76871741060116e-18	-39.6940819039397	106	72	0.031634446397188	2276	8202	6181,6235,9939,6193,6156,6135,6147,6217,6134,9775,5518,6194,2107,6227,6168,6222,6207,6159,6133,7311,11224,6160,6169,10921,6142,6232,4736,6203,3921,6167,6201,6233,6208,9045,6173,56006,2197,6188,6146,6231,6224,6202,6122,6209,6138,6125,23521,6137,9349,6139,6205,6170,6155,26019,6143,26986,6154,6144,6132,6171,6128,6229,6189,25873,6130,4686,6210,6158,6161,6223,6206,6152	RPLP2,RPS29,RBM8A,RPS5,RPL30,RPL11,RPL23A,RPS16,RPL10,EIF4A3,PPP2R1A,RPS6,ETF1,RPS21,RPL37A,RPS18,RPS13,RPL29,RPL9,UBA52,RPL35,RPL31,RPL38,RNPS1,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL37,RPS7,RPS27A,RPS14,RPL14,RPL36A,SMG9,FAU,RPS3,RPL22,RPS26,RPS20,RPS8,RPL3,RPS15,RPL15,RPL5,RPL13A,RPL13,RPL23,RPL17,RPS11,RPL39,RPL27,UPF2,RPL19,PABPC1,RPL26,RPL21,RPL8,RPL41,RPL6,RPS24,RPS3A,RPL36,RPL7A,NCBP1,RPS15A,RPL28,RPL32,RPS19,RPS12,RPL24
R-HSA-69620	Cell Cycle Checkpoints	1.29389437697582e-15	-34.2811198273754	179	100	0.0439367311072056	2276	8202	5883,7157,4998,7531,8365,4173,7465,5707,5696,5687,8364,10393,8379,1027,84126,51434,3017,5984,5983,5810,7311,991,85236,5695,10971,701,990,5884,8340,8697,4171,5982,995,983,7532,8318,8362,5719,7336,7158,6233,5714,5709,4085,84515,3014,51720,5690,165918,11200,5705,9861,128312,5700,7334,4172,51433,5689,4175,5693,55388,8367,144715,29086,5713,1111,4176,5715,8347,9491,8360,7341,6118,4174,545,5717,7314,23595,5686,5694,993,4999,5692,5702,5682,29882,9025,8363,5710,8368,5691,7316,5000,996,5001,7534,10197,7533,9133,11065	RAD9A,TP53,ORC1,YWHAE,HIST1H4H,MCM4,WEE1,PSMD1,PSMB8,PSMA6,HIST1H4C,ANAPC10,MAD1L1,CDKN1B,ATRIP,ANAPC7,HIST1H2BD,RFC4,RFC3,RAD1,UBA52,CDC20,HIST1H2BK,PSMB7,YWHAQ,BUB1B,CDC6,RAD17,HIST1H2BL,CDC23,MCM2,RFC2,CDC25C,CDK1,YWHAG,CDC45,HIST1H4K,PSMD13,UBE2V2,TP53BP1,RPS27A,PSMD8,PSMD3,MAD2L1,MCM8,H2AFX,UIMC1,PSMB2,RNF168,CHEK2,PSMC5,PSMD6,HIST3H2BB,PSMC1,UBE2N,MCM3,ANAPC5,PSMB1,MCM6,PSMB5,MCM10,HIST1H4E,RAD9B,BABAM1,PSMD7,CHEK1,MCM7,PSMD9,HIST1H2BC,PSMF1,HIST1H4D,SUMO1,RPA2,MCM5,ATR,PSMD11,UBB,ORC3,PSMA5,PSMB6,CDC25A,ORC2,PSMB4,PSMC3,PSMA1,ANAPC2,RNF8,HIST1H4J,PSMD4,HIST1H4L,PSMB3,UBC,ORC4,CDC27,ORC5,YWHAZ,PSME3,YWHAH,CCNB2,UBE2C
R-HSA-68886	M Phase	2.37150176980512e-15	-33.6752529822946	296	145	0.0637082601054482	2276	8202	3015,23511,2029,8350,11004,79003,8365,9183,5707,5696,10393,8379,9972,8331,7112,8615,7311,1058,723790,23133,85236,3021,9212,8340,983,5719,25936,6233,5714,91754,5527,5690,5705,128312,7443,5700,5528,8086,51433,5689,5693,1063,5713,5715,8347,23165,129401,4000,4927,2010,81876,9735,5686,10274,10112,5702,5682,8368,5691,84930,2801,996,23592,23636,9133,9818,9232,1460,5526,64900,9918,25836,5687,4001,55746,5518,8364,51434,3017,23141,348235,991,5695,6232,9631,701,8697,5861,8021,79682,3796,5529,5903,7514,8362,79980,5709,4085,7444,3014,8243,23122,10776,9861,151648,255919,6396,8367,8480,53371,55143,55055,64151,9491,8360,79172,91687,26271,151246,387893,653604,5717,79019,29781,7314,10051,5694,10726,11130,5692,140609,29882,8363,5710,7316,401541,23310,3012,332,147841,1062,10197,57082,54892,11065	H2AFZ,NUP188,ENSA,HIST1H3A,KIF2C,MIS12,HIST1H4H,ZW10,PSMD1,PSMB8,ANAPC10,MAD1L1,NUP153,HIST1H2AJ,TMPO,USO1,UBA52,CENPA,HIST2H2AA4,PHF8,HIST1H2BK,H3F3B,AURKB,HIST1H2BL,CDK1,PSMD13,NSL1,RPS27A,PSMD8,NEK9,PPP2R5C,PSMB2,PSMC5,HIST3H2BB,VRK1,PSMC1,PPP2R5D,AAAS,ANAPC5,PSMB1,PSMB5,CENPF,PSMD7,PSMD9,HIST1H2BC,NUP205,NUP35,LMNA,NUP88,EMD,RAB1B,KNTC1,PSMA5,STAG1,KIF20A,PSMC3,PSMA1,HIST1H4L,PSMB3,MASTL,GOLGA2,CDC27,LEMD3,NUP62,CCNB2,NUP58,PTTG1,CSNK2B,PPP2R5B,LPIN3,NCAPD2,NIPBL,PSMA6,LMNB1,NUP133,PPP2R1A,HIST1H4C,ANAPC7,HIST1H2BD,ANKLE2,SKA2,CDC20,PSMB7,RPS27,NUP155,BUB1B,CDC23,RAB1A,NUP214,CENPU,KIF2A,PPP2R5E,RANBP2,XPO1,HIST1H4K,DSN1,PSMD3,MAD2L1,VRK2,H2AFX,SMC1A,CLASP2,ARPP19,PSMD6,SGOL1,CNEP1R1,SEC13,HIST1H4E,RAE1,NUP54,CDCA8,ZWILCH,NCAPG,PSMF1,HIST1H4D,CENPO,CENPL,FBXO5,SGOL2,KMT5A,HIST2H3D,PSMD11,CENPM,NCAPH2,UBB,SMC4,PSMB6,NUDC,ZWINT,PSMB4,NEK7,ANAPC2,HIST1H4J,PSMD4,UBC,CENPP,NCAPD3,HIST1H2AE,BIRC5,SPC24,CENPE,PSME3,CASC5,NCAPG2,UBE2C
R-HSA-392499	Metabolism of proteins	3.00944595859572e-14	-31.13443530701	943	362	0.159050966608084	2276	8202	3015,23511,1801,5589,1964,11174,8350,7329,8365,6147,6484,1069,6217,6134,29928,6194,4124,26190,55770,89978,6227,8665,9972,10574,10342,1363,23275,6731,8615,6133,7311,3021,63917,8340,26503,90411,8661,5372,3703,10972,6233,6208,197370,9045,6747,6483,6188,128312,29080,83752,8704,8086,1725,64061,26088,23480,6480,79087,6748,23521,129401,134266,4000,811,6137,966,6184,23016,8894,6170,1603,81876,54872,10960,1537,26986,22870,1936,10959,5279,1984,6154,23404,51604,10274,1974,11253,6229,6746,5393,4580,10452,10694,56160,167227,59343,22872,6726,2677,2801,6158,1678,6223,8892,85365,55291,9818,1029,21,64924,10383,8664,9451,6015,440,6996,6464,8364,51399,84261,1639,10484,10576,23256,2931,6169,467,6232,5861,27230,6622,27335,6950,8362,1650,6201,286053,7466,1967,6400,3014,8243,6173,440138,22926,6224,6396,7184,10825,10905,567,506,641,1915,5281,7341,6139,79868,6143,22803,54512,10651,10678,1975,6144,375056,56648,6132,29071,10525,1973,10897,51128,6161,84061,5203,1802,1968,199857,7494,4802,8570,439,6152,1649,116138,6905,1911,9820,1798,9919,9487,10575,1499,25813,11340,6168,6222,1983,1977,8331,10159,7709,83475,118460,23137,468,723790,80273,6160,3309,85236,25870,84720,4736,29926,6167,10195,4582,55062,57171,4253,165918,55568,6231,6209,7094,9871,26272,79053,6138,128869,26519,7270,8347,6125,23165,56913,4927,57332,9349,1938,6205,55676,6729,56993,5277,9114,285381,6811,10113,516,6128,80267,5893,10282,84447,8368,9709,6934,25873,6130,27095,6675,60412,9554,23636,493861,498,54461,4351,9804,6181,6235,26984,6193,6156,5526,821,9117,1933,6135,26520,1200,56605,55746,1431,5537,6185,2107,23193,3017,144245,6207,10802,6159,11224,6734,1081,4597,6142,9631,131118,7416,8021,8666,6203,91869,8667,3921,401505,79947,5903,50,6903,10440,29925,8891,8662,6146,2197,6202,6122,26515,8367,8480,7095,10020,53371,29090,56886,1155,5373,6728,8360,4189,9632,6155,653604,51764,10559,55033,10381,9868,9761,8893,6171,7203,1294,8363,9669,4758,5201,6189,94027,11196,3012,3313,6210,6206,60559,79090	H2AFZ,NUP188,DPH1,PRKCSH,EIF1AX,ADAMTS6,HIST1H3A,UBE2I,HIST1H4H,RPL23A,ST3GAL4,CETN2,RPS16,RPL10,TIMM22,RPS6,MAN2A1,FBXW2,EXOC2,DPH6,RPS21,EIF3F,NUP153,CCT7,TFG,CPE,POFUT2,SRP72,USO1,RPL9,UBA52,H3F3B,GALNT11,HIST1H2BL,SLC17A5,MCFD2,EIF3A,PMM1,STT3A,TMED10,RPS27A,RPS14,NSMCE1,RPL14,SSR3,ST3GAL2,RPS3,HIST3H2BB,CCDC59,LONP2,B4GALT2,AAAS,DHPS,TSPYL2,GGA1,SEC61G,ST6GAL1,ALG12,SSR4,RPL13A,NUP35,GRPEL2,LMNA,CALR,RPL13,CD59,RPN1,EXOSC7,EIF2S2,RPL39,DAD1,RAB1B,PIGG,LMAN2,CYC1,PABPC1,PPP6R1,EEF1D,TMED2,PIGC,EIF5A,RPL26,EXOSC2,PIGT,STAG1,EIF4A2,MAN1B1,RPS24,SSR2,EXOSC9,MTX1,TOMM40,CCT8,NDNL2,DCP2,SENP2,SEC31A,SRP9,GGCX,GOLGA2,RPL28,TIMM8A,RPS19,EIF2B2,ALG2,PPP6R3,NUP58,CDKN2A,ABCA3,SLC30A5,TUBB4B,EIF3D,EIF2AK3,RING1,ASNS,TDG,SHC1,HIST1H4C,TRAPPC4,FBXW9,DCTN1,SEC23A,CCT2,SCFD1,GSK3A,RPL38,ATF3,RPS27,RAB1A,SERP1,SNCA,EIF3K,TCP1,HIST1H4K,DDOST,RPS7,NSMCE2,WFS1,EIF2B1,SEL1L,H2AFX,SMC1A,RPL36A,ALG11,ATF6,RPS20,SEC13,HSP90B1,NEU3,MAN1A2,B2M,ATP5B,BLM,EEF1A1,PIGF,SUMO1,RPL17,ALG13,RPL19,XRN2,EXOSC4,MTX2,B3GNT2,EIF4B,RPL21,MIA3,EIF5A2,RPL8,C1GALT1C1,HYOU1,EIF4A1,YIF1A,SAR1B,RPL32,MAGT1,PFDN4,DPH2,EIF2S3,ALG14,XBP1,NFYC,KHSRP,ASNA1,RPL24,DDIT3,KLHDC3,TBCE,PHC1,CUL7,DPAGT1,SEC16A,PIGL,CCT4,CTNNB1,SAMM50,EXOSC8,RPL37A,RPS18,EIF5,EIF4E,HIST1H2AJ,ATP6AP2,ZBTB17,DOHH,EXOSC6,SMC5,ATF4,HIST2H2AA4,GRPEL1,RPL31,HSPA5,HIST1H2BK,SUMF2,PIGO,RPL10A,GMPPA,RPL37,ALG3,MUC1,WIPI1,DOLPP1,CTAGE5,RNF168,GALNT10,RPS26,RPS15,TLN1,SEC24D,FBXO4,ALG8,RPL15,PIGU,TIMM10,TTF1,HIST1H2BC,RPL5,NUP205,C1GALT1,NUP88,CBX8,RPL23,EEF2,RPS11,SLC30A6,SRP54,TOMM22,PIGA,ATP6V0D1,DPH3,STX5,PREB,ATP5G1,RPL6,EDEM3,RAD52,BET1,SYVN1,HIST1H4L,HERPUD1,TCF7L2,RPL36,RPL7A,TRAPPC3,UAP1,EXOC4,SEC22B,NUP62,EID3,ATP5A1,FBXW5,MPI,TOMM20,RPLP2,RPS29,SEC22A,RPS5,RPL30,PPP2R5B,CANX,SEC22C,EEF1B2,RPL11,TIMM9,TPP1,ERO1B,NUP133,CS,PPP6C,RPN2,ETF1,GANAB,HIST1H2BD,ALG10B,RPS13,SEC24A,RPL29,RPL35,SRPR,CGA,MVD,RPL18A,NUP155,DNAJC19,VDAC1,NUP214,EIF3G,RPS9,RFT1,EIF3H,RPSA,TOMM5,DHDDS,RANBP2,ACO2,TBCC,TIMM17A,GMPPB,EIF2B3,EIF3B,RPL22,FAU,RPS8,RPL3,TIMM10B,HIST1H4E,RAE1,SEC62,GNE,NUP54,TIMM21,UGGT1,TBCB,PMM2,SRP19,HIST1H4D,DNAJB9,SEC24C,RPL27,HIST2H3D,GNG13,SLC35A1,FKBP14,TUBB3,TOMM70A,MLEC,EIF2B5,RPL41,CCT3,COL7A1,HIST1H4J,EIF5B,NEU1,PFDN1,RPS3A,CGB7,SEC23IP,HIST1H2AE,HSPA9,RPS15A,RPS12,SPCS3,TRAPPC6A
R-HSA-69242	S Phase	1.23039065682309e-13	-29.7262744827915	125	74	0.0325131810193322	2276	8202	23649,157570,4998,5424,4173,595,7465,5111,5707,5687,890,5696,51343,1027,2237,5984,7311,5983,902,1019,5695,990,4171,5982,84296,8318,5719,6233,5714,5709,84515,8243,5690,5981,5705,9861,5700,4172,5689,114799,5693,4175,5713,3978,4176,5715,9491,6118,4609,4174,1163,5717,7314,23595,57804,5686,5694,9837,993,4999,10274,5692,5422,5702,6502,5682,5710,10714,5691,7316,5000,5001,10197,5425	POLA2,ESCO2,ORC1,POLD1,MCM4,CCND1,WEE1,PCNA,PSMD1,PSMA6,CCNA2,PSMB8,FZR1,CDKN1B,FEN1,RFC4,UBA52,RFC3,CCNH,CDK4,PSMB7,CDC6,MCM2,RFC2,GINS4,CDC45,PSMD13,RPS27A,PSMD8,PSMD3,MCM8,SMC1A,PSMB2,RFC1,PSMC5,PSMD6,PSMC1,MCM3,PSMB1,ESCO1,PSMB5,MCM6,PSMD7,LIG1,MCM7,PSMD9,PSMF1,RPA2,MYC,MCM5,CKS1B,PSMD11,UBB,ORC3,POLD4,PSMA5,PSMB6,GINS1,CDC25A,ORC2,STAG1,PSMB4,POLA1,PSMC3,SKP2,PSMA1,PSMD4,POLD3,PSMB3,UBC,ORC4,ORC5,PSME3,POLD2
R-HSA-69239	Synthesis of DNA	1.78574560726561e-13	-29.3537701737547	98	62	0.0272407732864675	2276	8202	23649,5689,4175,5693,5713,3978,4998,5715,5424,4176,9491,4173,6118,5111,5707,5687,890,5696,4174,51343,1027,5717,23595,7314,57804,5686,2237,5694,9837,5984,4999,7311,5983,5692,5422,5702,5695,5682,990,5710,4171,10714,5982,5691,7316,84296,8318,5000,5719,6233,5714,5709,5001,84515,5690,5981,9861,10197,5705,5700,5425,4172	POLA2,PSMB1,MCM6,PSMB5,PSMD7,LIG1,ORC1,PSMD9,POLD1,MCM7,PSMF1,MCM4,RPA2,PCNA,PSMD1,PSMA6,CCNA2,PSMB8,MCM5,FZR1,CDKN1B,PSMD11,ORC3,UBB,POLD4,PSMA5,FEN1,PSMB6,GINS1,RFC4,ORC2,UBA52,RFC3,PSMB4,POLA1,PSMC3,PSMB7,PSMA1,CDC6,PSMD4,MCM2,POLD3,RFC2,PSMB3,UBC,GINS4,CDC45,ORC4,PSMD13,RPS27A,PSMD8,PSMD3,ORC5,MCM8,PSMB2,RFC1,PSMD6,PSME3,PSMC5,PSMC1,POLD2,MCM3
R-HSA-69306	DNA Replication	3.90249425140144e-13	-28.5719903085716	106	65	0.0285588752196837	2276	8202	23649,4998,5424,4173,5111,5707,5687,890,5696,51343,1027,2237,5984,7311,5983,1871,5695,990,4171,5982,84296,8318,5719,6233,5714,5709,84515,5690,5981,9861,5705,1870,5700,4172,5689,55388,5693,4175,5713,3978,4176,5715,9491,6118,4174,5717,7314,23595,57804,5686,5694,9837,4999,5692,5422,5702,5682,5710,10714,7316,5691,5000,5001,10197,5425	POLA2,ORC1,POLD1,MCM4,PCNA,PSMD1,PSMA6,CCNA2,PSMB8,FZR1,CDKN1B,FEN1,RFC4,UBA52,RFC3,E2F3,PSMB7,CDC6,MCM2,RFC2,GINS4,CDC45,PSMD13,RPS27A,PSMD8,PSMD3,MCM8,PSMB2,RFC1,PSMD6,PSMC5,E2F2,PSMC1,MCM3,PSMB1,MCM10,PSMB5,MCM6,PSMD7,LIG1,MCM7,PSMD9,PSMF1,RPA2,MCM5,PSMD11,UBB,ORC3,POLD4,PSMA5,PSMB6,GINS1,ORC2,PSMB4,POLA1,PSMC3,PSMA1,PSMD4,POLD3,UBC,PSMB3,ORC4,ORC5,PSME3,POLD2
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	8.62441248767399e-13	-27.7790093656964	143	80	0.0351493848857645	2276	8202	79944,51204,4712,8802,7381,4191,5166,7351,521,51079,54539,51241,4709,7386,9997,5164,84987,517,55471,1431,7385,4731,4700,4705,1738,4720,285521,5160,1350,5163,27089,2271,1353,57546,2739,514,4701,4967,1743,513,6392,50,25915,126328,4694,9377,7388,4713,1340,4729,6391,682,54205,506,374291,4723,1337,10476,4708,4728,1349,1537,55967,4696,516,10632,54704,51300,3939,9551,3029,5467,9167,29078,1351,10128,6566,498,4725,3420	L2HGDH,TACO1,NDUFB6,SUCLG1,UQCRB,MDH2,PDK4,UCP2,ATP5I,NDUFA13,NDUFB11,COX16,NDUFB3,UQCRFS1,SCO2,PDK2,COX14,ATP5G2,NDUFAF7,CS,UQCRC2,NDUFV3,NDUFA6,NDUFA10,DLD,NDUFS2,COX18,PDHA1,COX7C,PDK1,UQCRQ,FH,COX11,PDP2,GLO1,ATP5E,NDUFA7,OGDH,DLST,ATP5D,SDHD,ACO2,NDUFAF3,NDUFA11,NDUFA1,COX5A,UQCRH,NDUFB7,COX6B1,NDUFV2,SDHC,BSG,CYCS,ATP5B,NDUFS7,NDUFV1,COX6A1,ATP5H,NDUFB2,NDUFS8,COX7B,CYC1,NDUFA12,NDUFA3,ATP5G1,ATP5L,PDP1,TIMMDC1,LDHA,ATP5J2,HAGH,PPARD,COX7A2L,NDUFAF4,COX8A,LRPPRC,SLC16A1,ATP5A1,NDUFS5,IDH3B
R-HSA-1643685	Disease	1.62362865255331e-12	-27.1463575625571	657	262	0.115114235500879	2276	8202	23511,8805,27249,4869,6777,1488,6147,805,6217,5707,6134,6843,6194,8907,163,9972,6227,6882,64223,6133,7311,8731,208,842,5432,572,5719,112812,6233,5714,6208,9045,5527,2932,6188,29080,3066,8086,4836,5689,4594,5440,23327,5715,23521,129401,811,6137,4609,6170,64087,6154,5702,6229,6616,7469,6875,84168,4548,5691,7520,6158,160,6223,9818,1147,324,162,51293,6464,1027,253260,5970,11052,2237,6881,902,2931,3326,9525,6169,6232,2958,10014,11198,6873,8517,5529,7514,9759,6201,2547,6400,6772,6173,6224,6908,567,84335,9491,3105,5478,2962,6139,83860,2232,5781,6143,145957,2065,2068,7314,5694,5170,5609,6144,6132,5710,5430,7316,4686,6161,5091,6152,3159,10197,6878,8945,142678,2071,56922,10013,6382,5606,4552,5696,1499,5296,6168,6917,6222,11140,3841,51107,6160,4736,7415,6167,7251,5690,5705,6231,5700,5528,6884,6209,5693,6872,51534,5713,3978,6138,6125,7270,23165,8178,9349,4927,1938,6205,4040,2965,2960,51606,9794,5686,5431,6128,5682,3845,6921,84447,6829,6934,25873,6130,5434,23636,6907,27243,25974,6181,2475,6235,5604,6156,6193,5526,821,8658,6135,5687,55746,5518,2968,3551,2997,8503,4791,6207,6159,11224,6877,5695,9631,6142,25978,8021,6203,3921,5903,5709,2197,6146,9861,1175,23385,6122,6202,9150,8480,53371,1452,2963,6155,5717,3320,2959,6774,3837,6199,7296,3280,6868,5692,1024,7936,3164,6171,51652,222236,3304,22943,6189,3840,6210,5608,79720,6206,6883,3516,164	NUP188,TRIM24,MMADHC,NPM1,STAT5B,CTBP2,RPL23A,CALM2,RPS16,PSMD1,RPL10,VAMP1,RPS6,AP1M1,AP2B1,NUP153,RPS21,TAF11,MLST8,RPL9,UBA52,RNMT,AKT2,CASP9,POLR2C,BAD,PSMD13,FDX1L,RPS27A,PSMD8,RPS14,RPL14,PPP2R5C,GSK3B,RPS3,CCDC59,HDAC2,AAAS,NMT1,PSMB1,MUT,POLR2K,NEDD4L,PSMD9,RPL13A,NUP35,CALR,RPL13,MYC,RPL39,MCCC2,RPL26,PSMC3,RPS24,SNAP25,NELFA,TAF4B,ANTXR1,MTR,PSMB3,XRCC5,RPL28,AP2A1,RPS19,NUP58,CHUK,APC,AP1B1,CD320,SHC1,CDKN1B,RICTOR,RELA,CPSF6,FEN1,TAF10,CCNH,GSK3A,HSP90AB1,VPS4B,RPL38,RPS27,GTF2A2,HDAC5,SUPT16H,TAF2,IKBKG,PPP2R5E,XPO1,HDAC4,RPS7,XRCC6,SEL1L,STAT1,RPL36A,RPS20,TBP,B2M,AKT1S1,PSMF1,HLA-A,PPIA,GTF2F1,RPL17,TAF3,FDXR,PTPN11,RPL19,NRG4,ERBB3,ERCC2,UBB,PSMB6,PDPK1,MAP2K7,RPL21,RPL8,PSMD4,POLR2A,UBC,NCBP1,RPL32,PC,RPL24,HMGA1,PSME3,TAF6,BTRC,MIB2,ERCC3,MCCC1,HDAC6,SDC1,MAP2K3,MTRR,PSMB8,CTNNB1,PIK3R2,RPL37A,TCEA1,RPS18,CDC37,KPNA5,APH1A,RPL31,RPL10A,VCP,RPL37,TSG101,PSMB2,PSMC5,RPS26,PSMC1,PPP2R5D,TAF13,RPS15,PSMB5,TAF1,VTA1,PSMD7,LIG1,RPL15,RPL5,TTF1,NUP205,ELL,RPL23,NUP88,EEF2,RPS11,LRP6,GTF2H1,GTF2E1,ATP6V1H,MAML1,PSMA5,POLR2B,RPL6,PSMA1,KRAS,TCEB1,SYVN1,SUPT5H,TCF7L2,RPL36,RPL7A,POLR2E,NUP62,TBL1X,CHMP2A,MMACHC,RPLP2,MTOR,RPS29,MAP2K1,RPL30,RPS5,PPP2R5B,CANX,TNKS,RPL11,PSMA6,NUP133,PPP2R1A,GTF2H4,IKBKB,GYS1,PIK3R3,NFKB2,RPS13,RPL29,RPL35,TAF5,PSMB7,NUP155,RPL18A,CHMP2B,NUP214,RPS9,RPSA,RANBP2,PSMD3,FAU,RPL22,PSMD6,AP2S1,NCSTN,RPL3,RPS8,CTDP1,RAE1,NUP54,CSNK1A1,GTF2F2,RPL27,PSMD11,HSP90AA1,GTF2B,STAT3,KPNB1,RPS6KB2,TXNRD1,HES1,ADAM17,PSMB4,CDK8,NELFE,NR4A1,RPL41,CHMP3,NAPEPLD,HSPA1B,DKK1,RPS3A,KPNA4,RPS15A,MAP2K6,VPS37B,RPS12,TAF12,RBPJ,AP1G1
R-HSA-72702	Ribosomal scanning and start codon recognition	4.71389939669745e-12	-26.0805056530302	55	40	0.0175746924428823	2276	8202	6224,6202,6209,8664,1964,6235,6193,6217,8894,6205,6194,6227,8665,6222,1983,1977,6207,1975,1974,6229,6232,1973,6203,8666,8667,3921,8661,6189,27335,6210,1968,6201,6233,6208,6223,6206,6188,8662,2197,6231	RPS20,RPS8,RPS15,EIF3D,EIF1AX,RPS29,RPS5,RPS16,EIF2S2,RPS11,RPS6,RPS21,EIF3F,RPS18,EIF5,EIF4E,RPS13,EIF4B,EIF4A2,RPS24,RPS27,EIF4A1,RPS9,EIF3G,EIF3H,RPSA,EIF3A,RPS3A,EIF3K,RPS15A,EIF2S3,RPS7,RPS27A,RPS14,RPS19,RPS12,RPS3,EIF3B,FAU,RPS26
R-HSA-72649	Translation initiation complex formation	4.71389939669745e-12	-26.0805056530302	55	40	0.0175746924428823	2276	8202	6224,6202,6209,8664,1964,6235,6193,6217,8894,6205,6194,6227,8665,6222,1977,26986,6207,1975,1974,6229,6232,1973,6203,8666,8667,3921,8661,6189,27335,6210,1968,6201,6233,6208,6223,6206,6188,8662,2197,6231	RPS20,RPS8,RPS15,EIF3D,EIF1AX,RPS29,RPS5,RPS16,EIF2S2,RPS11,RPS6,RPS21,EIF3F,RPS18,EIF4E,PABPC1,RPS13,EIF4B,EIF4A2,RPS24,RPS27,EIF4A1,RPS9,EIF3G,EIF3H,RPSA,EIF3A,RPS3A,EIF3K,RPS15A,EIF2S3,RPS7,RPS27A,RPS14,RPS19,RPS12,RPS3,EIF3B,FAU,RPS26
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	1.20974798537064e-11	-25.1380239615716	56	40	0.0175746924428823	2276	8202	6224,6202,6209,8664,1964,6235,6193,6217,8894,6205,6194,6227,8665,6222,1977,26986,6207,1975,1974,6229,6232,1973,6203,8666,8667,3921,8661,6189,27335,6210,1968,6201,6233,6208,6223,6206,6188,8662,2197,6231	RPS20,RPS8,RPS15,EIF3D,EIF1AX,RPS29,RPS5,RPS16,EIF2S2,RPS11,RPS6,RPS21,EIF3F,RPS18,EIF4E,PABPC1,RPS13,EIF4B,EIF4A2,RPS24,RPS27,EIF4A1,RPS9,EIF3G,EIF3H,RPSA,EIF3A,RPS3A,EIF3K,RPS15A,EIF2S3,RPS7,RPS27A,RPS14,RPS19,RPS12,RPS3,EIF3B,FAU,RPS26
R-HSA-73894	DNA Repair	1.30565041002771e-11	-25.0617347078305	306	139	0.0610720562390158	2276	8202	5883,5423,9682,2071,54617,2177,7329,55215,8365,1069,5111,29089,51138,7516,5887,54778,6917,2067,7311,5810,51548,83932,85236,8340,5982,7415,5432,79661,9768,675,50813,56852,7158,6233,9031,7320,2073,165918,11200,128312,86,4913,5440,57461,3978,1111,11284,8347,55666,8178,91442,8533,57654,4436,2965,545,7398,125476,57804,5431,1643,11073,5531,5893,8368,7515,7520,10973,5980,5434,91603,5425,2176,83990,56949,7157,5424,5886,890,6996,64858,2968,121642,8364,11201,84126,79913,9716,3017,2237,27339,5984,5983,902,10038,5884,2189,9156,5889,8362,8607,23030,2074,7336,80233,10987,2547,3014,199990,51720,7517,5981,348654,7334,4595,8367,144715,29086,55183,4292,641,8360,7341,6118,6047,2068,7314,2956,3150,9318,7156,8363,9025,57697,10714,5430,7316,29844,1642	RAD9A,POLB,KDM4A,ERCC3,INO80,FANCD2,UBE2I,FANCI,HIST1H4H,CETN2,PCNA,UBE2T,COPS4,XRCC2,RAD23B,RNF111,TCEA1,ERCC1,UBA52,RAD1,SIRT6,SPRTN,HIST1H2BK,HIST1H2BL,RFC2,VCP,POLR2C,NEIL1,KIAA0101,BRCA2,COPS7A,RAD18,TP53BP1,RPS27A,BAZ1B,UBE2B,ERCC5,RNF168,CHEK2,HIST3H2BB,ACTL6A,NTHL1,POLR2K,ISY1,LIG1,CHEK1,PNKP,HIST1H2BC,NPLOC4,ELL,FAAP24,COPS3,UVSSA,MSH2,GTF2H1,ATR,USP1,INO80C,POLD4,POLR2B,DDB2,TOPBP1,PPP4C,RAD52,HIST1H4L,XRCC1,XRCC5,ASCC3,REV3L,POLR2E,ZNF830,POLD2,FANCC,BRIP1,XAB2,TP53,POLD1,RAD23A,CCNA2,TDG,DCLRE1B,GTF2H4,ALKBH2,HIST1H4C,POLI,ATRIP,ACTR5,AQR,HIST1H2BD,FEN1,PRPF19,RFC4,RFC3,CCNH,PARP2,RAD17,FANCG,EXO1,RAD51C,HIST1H4K,RUVBL1,KDM4B,ERCC6,UBE2V2,FAAP100,COPS5,XRCC6,H2AFX,FAAP20,UIMC1,XRCC3,RFC1,GEN1,UBE2N,MUTYH,HIST1H4E,RAD9B,BABAM1,RIF1,MLH1,BLM,HIST1H4D,SUMO1,RPA2,RNF4,ERCC2,UBB,MSH6,HMGN1,COPS2,TOP3A,HIST1H4J,RNF8,FANCM,POLD3,POLR2A,UBC,TFPT,DDB1
R-HSA-453279	Mitotic G1-G1/S phases	2.38012249139078e-11	-24.4612840696046	135	74	0.0325131810193322	2276	8202	23649,1875,4998,132660,4173,595,7465,5111,5707,5687,890,5696,5518,1027,1032,1021,7311,902,1019,1871,5695,6241,990,4171,983,8318,5719,5933,6233,5714,5709,84515,5690,9861,5705,1870,5700,4172,55957,1030,5689,55388,5693,4175,5713,4176,5715,9491,26271,6118,7153,4609,4174,1163,5717,7314,23595,5686,5694,993,4999,5692,5422,5702,6502,5682,5710,5691,7316,1859,5000,5001,10197,1029	POLA2,E2F5,ORC1,LIN54,MCM4,CCND1,WEE1,PCNA,PSMD1,PSMA6,CCNA2,PSMB8,PPP2R1A,CDKN1B,CDKN2D,CDK6,UBA52,CCNH,CDK4,E2F3,PSMB7,RRM2,CDC6,MCM2,CDK1,CDC45,PSMD13,RBL1,RPS27A,PSMD8,PSMD3,MCM8,PSMB2,PSMD6,PSMC5,E2F2,PSMC1,MCM3,LIN37,CDKN2B,PSMB1,MCM10,PSMB5,MCM6,PSMD7,MCM7,PSMD9,PSMF1,FBXO5,RPA2,TOP2A,MYC,MCM5,CKS1B,PSMD11,UBB,ORC3,PSMA5,PSMB6,CDC25A,ORC2,PSMB4,POLA1,PSMC3,SKP2,PSMA1,PSMD4,PSMB3,UBC,DYRK1A,ORC4,ORC5,PSME3,CDKN2A
R-HSA-2555396	Mitotic Metaphase and Anaphase	2.42607937938966e-11	-24.4421594926719	173	89	0.039103690685413	2276	8202	9232,5526,11004,79003,9183,5707,5687,5696,4001,5518,55746,10393,8379,51434,7112,23141,1058,7311,348235,991,5695,701,6232,9212,8697,79682,3796,5903,5529,7514,79980,25936,5719,6233,5714,5709,4085,8243,7444,5527,5690,23122,5705,9861,151648,7443,5700,5528,51433,5689,6396,5693,1063,5713,55143,55055,5715,9491,91687,4000,79172,26271,2010,151246,5717,9735,79019,7314,5686,10726,5694,11130,5692,10274,5702,5682,29882,5710,5691,7316,401541,996,332,23592,147841,1062,10197,57082,11065	PTTG1,PPP2R5B,KIF2C,MIS12,ZW10,PSMD1,PSMA6,PSMB8,LMNB1,PPP2R1A,NUP133,ANAPC10,MAD1L1,ANAPC7,TMPO,ANKLE2,CENPA,UBA52,SKA2,CDC20,PSMB7,BUB1B,RPS27,AURKB,CDC23,CENPU,KIF2A,RANBP2,PPP2R5E,XPO1,DSN1,NSL1,PSMD13,RPS27A,PSMD8,PSMD3,MAD2L1,SMC1A,VRK2,PPP2R5C,PSMB2,CLASP2,PSMC5,PSMD6,SGOL1,VRK1,PSMC1,PPP2R5D,ANAPC5,PSMB1,SEC13,PSMB5,CENPF,PSMD7,CDCA8,ZWILCH,PSMD9,PSMF1,CENPL,LMNA,CENPO,FBXO5,EMD,SGOL2,PSMD11,KNTC1,CENPM,UBB,PSMA5,NUDC,PSMB6,ZWINT,PSMB4,STAG1,PSMC3,PSMA1,ANAPC2,PSMD4,PSMB3,UBC,CENPP,CDC27,BIRC5,LEMD3,SPC24,CENPE,PSME3,CASC5,UBE2C
R-HSA-162906	HIV Infection	3.04489178550381e-11	-24.2149706608265	221	107	0.04701230228471	2276	8202	27243,23511,2071,4869,162,5696,5687,5707,2968,55746,8907,163,9972,6917,6882,2237,6881,6877,7311,902,8731,5695,9525,9631,25978,2958,8021,11198,5432,6873,5903,7514,5719,6233,5714,5709,2547,5690,7251,9861,5705,5700,1175,8086,4836,5689,6884,9150,5693,6872,5440,6908,8480,51534,53371,5713,3978,23327,567,5715,9491,23165,3105,5478,129401,2962,8178,4927,83860,2963,2965,5717,2960,2068,7314,51606,2959,5431,5686,3837,5694,5692,7936,5702,5682,6921,51652,7469,5710,6875,6829,5430,5691,7316,7520,4686,160,79720,5434,23636,3159,6883,10197,164,6878,9818,8945	CHMP2A,NUP188,ERCC3,NPM1,AP1B1,PSMB8,PSMA6,PSMD1,GTF2H4,NUP133,AP1M1,AP2B1,NUP153,TCEA1,TAF11,FEN1,TAF10,TAF5,UBA52,CCNH,RNMT,PSMB7,VPS4B,NUP155,CHMP2B,GTF2A2,NUP214,SUPT16H,POLR2C,TAF2,RANBP2,XPO1,PSMD13,RPS27A,PSMD8,PSMD3,XRCC6,PSMB2,TSG101,PSMD6,PSMC5,PSMC1,AP2S1,AAAS,NMT1,PSMB1,TAF13,CTDP1,PSMB5,TAF1,POLR2K,TBP,RAE1,VTA1,NUP54,PSMD7,LIG1,NEDD4L,B2M,PSMD9,PSMF1,NUP205,HLA-A,PPIA,NUP35,GTF2F1,ELL,NUP88,TAF3,GTF2F2,GTF2H1,PSMD11,GTF2E1,ERCC2,UBB,ATP6V1H,GTF2B,POLR2B,PSMA5,KPNB1,PSMB6,PSMB4,NELFE,PSMC3,PSMA1,TCEB1,CHMP3,NELFA,PSMD4,TAF4B,SUPT5H,POLR2A,PSMB3,UBC,XRCC5,NCBP1,AP2A1,VPS37B,POLR2E,NUP62,HMGA1,TAF12,PSME3,AP1G1,TAF6,NUP58,BTRC
R-HSA-68882	Mitotic Anaphase	4.60830447275056e-11	-23.8005760269081	172	88	0.0386643233743409	2276	8202	9232,5526,11004,79003,9183,5707,5687,5696,4001,5518,55746,10393,8379,51434,7112,23141,1058,7311,348235,991,5695,701,6232,9212,8697,79682,3796,5903,5529,7514,79980,25936,5719,6233,5714,5709,4085,8243,7444,5527,5690,23122,5705,9861,151648,7443,5700,5528,51433,5689,6396,5693,1063,5713,55143,55055,5715,9491,91687,4000,79172,2010,151246,5717,9735,79019,7314,5686,10726,5694,11130,5692,10274,5702,5682,29882,5710,5691,7316,401541,996,332,23592,147841,1062,10197,57082,11065	PTTG1,PPP2R5B,KIF2C,MIS12,ZW10,PSMD1,PSMA6,PSMB8,LMNB1,PPP2R1A,NUP133,ANAPC10,MAD1L1,ANAPC7,TMPO,ANKLE2,CENPA,UBA52,SKA2,CDC20,PSMB7,BUB1B,RPS27,AURKB,CDC23,CENPU,KIF2A,RANBP2,PPP2R5E,XPO1,DSN1,NSL1,PSMD13,RPS27A,PSMD8,PSMD3,MAD2L1,SMC1A,VRK2,PPP2R5C,PSMB2,CLASP2,PSMC5,PSMD6,SGOL1,VRK1,PSMC1,PPP2R5D,ANAPC5,PSMB1,SEC13,PSMB5,CENPF,PSMD7,CDCA8,ZWILCH,PSMD9,PSMF1,CENPL,LMNA,CENPO,EMD,SGOL2,PSMD11,KNTC1,CENPM,UBB,PSMA5,NUDC,PSMB6,ZWINT,PSMB4,STAG1,PSMC3,PSMA1,ANAPC2,PSMD4,PSMB3,UBC,CENPP,CDC27,BIRC5,LEMD3,SPC24,CENPE,PSME3,CASC5,UBE2C
R-HSA-69304	Regulation of DNA replication	5.40916788394523e-11	-23.6403407526372	75	48	0.0210896309314587	2276	8202	5689,4175,5693,55388,5713,4998,5715,4176,9491,4173,5707,5687,890,5696,4174,51343,1027,5717,23595,7314,5686,5694,4999,7311,5692,5702,5695,1871,5682,990,5710,4171,5691,7316,5000,5719,6233,5714,5709,5001,84515,5690,10197,9861,5705,1870,5700,4172	PSMB1,MCM6,PSMB5,MCM10,PSMD7,ORC1,PSMD9,MCM7,PSMF1,MCM4,PSMD1,PSMA6,CCNA2,PSMB8,MCM5,FZR1,CDKN1B,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,PSMC3,PSMB7,E2F3,PSMA1,CDC6,PSMD4,MCM2,PSMB3,UBC,ORC4,PSMD13,RPS27A,PSMD8,PSMD3,ORC5,MCM8,PSMB2,PSME3,PSMD6,PSMC5,E2F2,PSMC1,MCM3
R-HSA-983169	Class I MHC mediated antigen processing & presentation	6.65736969622249e-11	-23.4327115568989	267	123	0.0540421792618629	2276	8202	23291,90933,9820,7317,84231,55284,23304,6890,55585,821,9867,5707,5696,5687,8651,197131,10193,51343,79876,10393,51619,54778,23295,51434,64219,26259,10802,140739,10484,7311,991,3309,5695,868,7335,8697,23352,56658,5719,7336,6233,5714,5709,7174,23608,10533,7320,5690,51130,5705,9861,5700,7334,55521,7323,51433,5689,6396,5693,9320,9871,23480,25831,9903,3133,3134,26272,4012,5713,140462,23327,567,80196,9354,5715,9491,4734,3105,811,27252,9632,8139,51465,6047,26046,5717,89910,3107,7314,54926,90678,9730,5686,5694,5692,25847,5702,6502,7319,7328,5682,29882,6921,5710,4591,55236,5691,10425,7316,51128,22872,996,8453,7322,51444,51752,27338,23376,10197,9604,11065,8945,63891	FBXW11,TRIM41,CUL7,UBA1,TRAF7,UBE2W,UBR2,TAP1,UBE2Q1,CANX,PJA2,PSMD1,PSMB8,PSMA6,SOCS1,UBR1,RNF41,FZR1,UBA5,ANAPC10,UBE2D4,RNF111,MGRN1,ANAPC7,PJA1,FBXW8,SEC24A,UBE2F,SEC23A,UBA52,CDC20,HSPA5,PSMB7,CBLB,UBE2V1,CDC23,UBR4,TRIM39,PSMD13,UBE2V2,RPS27A,PSMD8,PSMD3,TPP2,MKRN1,ATG7,UBE2B,PSMB2,ASB3,PSMC5,PSMD6,PSMC1,UBE2N,TRIM36,UBE2D3,ANAPC5,PSMB1,SEC13,PSMB5,TRIP12,SEC24D,SEC61G,HECTD1,KLHL21,HLA-E,HLA-F,FBXO4,LNPEP,PSMD7,ASB9,NEDD4L,B2M,RNF34,UBE4A,PSMD9,PSMF1,NEDD4,HLA-A,CALR,KLHL20,SEC24C,GAN,UBE2J1,RNF4,LTN1,PSMD11,UBE3B,HLA-C,UBB,UBE2R2,LRSAM1,VPRBP,PSMA5,PSMB6,PSMB4,ANAPC13,PSMC3,SKP2,UBE2A,UBE2H,PSMA1,ANAPC2,TCEB1,PSMD4,TRIM37,UBA6,PSMB3,ARIH2,UBC,SAR1B,SEC31A,CDC27,CUL2,UBE2D2,RNF138,ERAP1,UBE2S,UFL1,PSME3,RNF14,UBE2C,BTRC,RNF123
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	9.26882219228646e-11	-23.1017797072773	48	35	0.015377855887522	2276	8202	6224,6202,6209,8664,1964,6235,6193,6217,8894,6205,6194,6227,8665,6222,6207,6229,6232,6203,8666,8667,3921,8661,6189,27335,6210,1968,6201,6233,6208,6223,6206,2197,8662,6188,6231	RPS20,RPS8,RPS15,EIF3D,EIF1AX,RPS29,RPS5,RPS16,EIF2S2,RPS11,RPS6,RPS21,EIF3F,RPS18,RPS13,RPS24,RPS27,RPS9,EIF3G,EIF3H,RPSA,EIF3A,RPS3A,EIF3K,RPS15A,EIF2S3,RPS7,RPS27A,RPS14,RPS19,RPS12,FAU,EIF3B,RPS3,RPS26
R-HSA-68867	Assembly of the pre-replicative complex	9.77659420825308e-11	-23.0484448400025	67	44	0.0193321616871705	2276	8202	5689,4175,5693,5713,4998,5715,4176,9491,4173,5707,5687,5696,4174,5717,23595,7314,5686,5694,4999,7311,5692,5702,5695,1871,5682,990,5710,4171,5691,7316,5000,5719,6233,5714,5709,5001,84515,5690,10197,9861,5705,1870,5700,4172	PSMB1,MCM6,PSMB5,PSMD7,ORC1,PSMD9,MCM7,PSMF1,MCM4,PSMD1,PSMA6,PSMB8,MCM5,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,PSMC3,PSMB7,E2F3,PSMA1,CDC6,PSMD4,MCM2,PSMB3,UBC,ORC4,PSMD13,RPS27A,PSMD8,PSMD3,ORC5,MCM8,PSMB2,PSME3,PSMD6,PSMC5,E2F2,PSMC1,MCM3
R-HSA-69300	Removal of licensing factors from origins	1.49113119779474e-10	-22.6263159048736	72	46	0.0202108963093146	2276	8202	5689,4175,5693,55388,5713,4998,5715,4176,9491,4173,5707,5687,890,5696,4174,51343,1027,5717,23595,7314,5686,5694,4999,7311,5692,5702,5695,5682,990,5710,4171,5691,7316,5000,5719,6233,5714,5709,5001,84515,5690,10197,9861,5705,5700,4172	PSMB1,MCM6,PSMB5,MCM10,PSMD7,ORC1,PSMD9,MCM7,PSMF1,MCM4,PSMD1,PSMA6,CCNA2,PSMB8,MCM5,FZR1,CDKN1B,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,CDC6,PSMD4,MCM2,PSMB3,UBC,ORC4,PSMD13,RPS27A,PSMD8,PSMD3,ORC5,MCM8,PSMB2,PSME3,PSMD6,PSMC5,PSMC1,MCM3
R-HSA-68949	Orc1 removal from chromatin	1.74426772686861e-10	-22.4695161031229	70	45	0.0197715289982425	2276	8202	5689,4175,5693,5713,4998,5715,4176,9491,4173,5707,5687,890,5696,4174,51343,1027,5717,23595,7314,5686,5694,4999,7311,5692,5702,5695,5682,990,5710,4171,5691,7316,5000,5719,6233,5714,5709,5001,84515,5690,10197,9861,5705,5700,4172	PSMB1,MCM6,PSMB5,PSMD7,ORC1,PSMD9,MCM7,PSMF1,MCM4,PSMD1,PSMA6,CCNA2,PSMB8,MCM5,FZR1,CDKN1B,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,CDC6,PSMD4,MCM2,PSMB3,UBC,ORC4,PSMD13,RPS27A,PSMD8,PSMD3,ORC5,MCM8,PSMB2,PSME3,PSMD6,PSMC5,PSMC1,MCM3
R-HSA-69052	Switching of origins to a post-replicative state	1.74426772686861e-10	-22.4695161031229	70	45	0.0197715289982425	2276	8202	5689,4175,5693,5713,4998,5715,4176,9491,4173,5707,5687,890,5696,4174,51343,1027,5717,23595,7314,5686,5694,4999,7311,5692,5702,5695,5682,990,5710,4171,5691,7316,5000,5719,6233,5714,5709,5001,84515,5690,10197,9861,5705,5700,4172	PSMB1,MCM6,PSMB5,PSMD7,ORC1,PSMD9,MCM7,PSMF1,MCM4,PSMD1,PSMA6,CCNA2,PSMB8,MCM5,FZR1,CDKN1B,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,CDC6,PSMD4,MCM2,PSMB3,UBC,ORC4,PSMD13,RPS27A,PSMD8,PSMD3,ORC5,MCM8,PSMB2,PSME3,PSMD6,PSMC5,PSMC1,MCM3
R-HSA-2262752	Cellular responses to stress	2.02003378554271e-10	-22.322736693151	379	161	0.0707381370826011	2276	8202	3015,23511,6767,60673,5565,8350,7531,10013,7290,8678,5606,8365,6196,11337,5034,64422,51343,26277,10393,9972,1021,8331,11152,64223,7311,723790,1019,55054,3309,3312,85236,8550,23466,57805,9140,5571,3021,8340,6009,7415,55062,6233,2932,128312,25828,1870,8086,7323,51433,10808,5562,30849,54205,3337,8347,493869,23165,129401,115201,3725,4927,57332,5601,545,5598,7014,7867,6921,8368,51501,7248,51422,2114,996,389541,23636,4217,23192,9818,192669,1029,5564,27243,3397,2475,8655,7157,91582,6015,54386,890,4001,65057,55746,10049,8364,28956,1027,51434,112399,5970,1032,3017,23411,3326,1871,9631,8697,25978,8021,23710,5903,817,3308,8362,112398,3014,10533,55662,9474,4343,405,1030,23112,7405,8367,8480,53371,84335,1915,8360,84938,6118,653604,9776,6782,3320,10728,7314,6774,6667,7296,5289,5931,5609,29882,8363,51652,2353,5052,7316,3304,3012,3313,3569,5608,8453,7322,3159,11065,1911	H2AFZ,NUP188,ST13,ATG101,PRKAB2,HIST1H3A,YWHAE,HDAC6,HIRA,BECN1,MAP2K3,HIST1H4H,RPS6KA2,GABARAP,P4HB,ATG3,FZR1,TINF2,ANAPC10,NUP153,CDK6,HIST1H2AJ,WDR45,MLST8,UBA52,HIST2H2AA4,CDK4,ATG16L1,HSPA5,HSPA8,HIST1H2BK,MAPKAPK5,CBX6,CCAR2,ATG12,PRKAG1,H3F3B,HIST1H2BL,RHEB,VCP,WIPI1,RPS27A,GSK3B,HIST3H2BB,TXN2,E2F2,AAAS,UBE2D3,ANAPC5,HSPH1,PRKAA1,PIK3R4,CYCS,DNAJB1,HIST1H2BC,GPX8,NUP205,NUP35,ATG4A,JUN,NUP88,CBX8,MAPK9,ATR,MAPK7,TERF2,MAPKAPK3,TCEB1,HIST1H4L,C11orf73,TSC1,PRKAG2,ETS2,CDC27,LAMTOR4,NUP62,MAP3K5,ATG4B,NUP58,AGO3,CDKN2A,PRKAB1,CHMP2A,ID1,MTOR,DYNLL1,TP53,RPS19BP1,RING1,TERF2IP,CCNA2,LMNB1,ACD,NUP133,DNAJB6,HIST1H4C,LAMTOR2,CDKN1B,ANAPC7,EGLN3,RELA,CDKN2D,HIST1H2BD,SIRT1,HSP90AB1,E2F3,NUP155,CDC23,CHMP2B,NUP214,GABARAPL1,RANBP2,CAMK2D,HSPA4,HIST1H4K,EGLN2,H2AFX,ATG7,HIF1AN,ATG5,MOV10,ARNT,CDKN2B,TNRC6B,UVRAG,HIST1H4E,RAE1,NUP54,AKT1S1,EEF1A1,HIST1H4D,ATG4C,RPA2,HIST2H3D,ATG13,HSPA13,HSP90AA1,PTGES3,UBB,STAT3,SP1,TXNRD1,PIK3C3,RBBP7,MAP2K7,ANAPC2,HIST1H4J,CHMP3,FOS,PRDX1,UBC,HSPA1B,HIST1H2AE,HSPA9,IL6,MAP2K6,CUL2,UBE2D2,HMGA1,UBE2C,PHC1
R-HSA-5617833	Assembly of the primary cilium	3.65052410390482e-10	-21.7309801825432	180	89	0.039103690685413	2276	8202	26123,83658,10142,261734,80321,10383,8655,54903,26160,79738,55212,89891,7531,10013,5566,8729,10575,9727,79809,1069,4218,23059,5147,5518,84131,10733,55770,1639,64792,10576,91147,1454,129880,121441,79959,983,7532,378,84100,51668,6950,11190,55764,200894,92482,9742,146057,203068,11258,22995,1781,10540,585,9321,4735,27241,11020,8766,22897,9702,83657,9738,80184,55835,90410,55112,3320,51134,9657,112752,55755,7203,347240,80173,22994,10694,166379,132320,5108,79989,4957,10806,57728,60412,8481,51626,8636,55125,4867	TCTN3,DYNLRB1,AKAP9,NPHP4,CEP70,TUBB4B,DYNLL1,MKS1,IFT172,BBS10,BBS7,WDR34,YWHAE,HDAC6,PRKACA,GBF1,CCT4,RAB11FIP3,TTC21B,CETN2,RAB8A,CLUAP1,PDE6D,PPP2R1A,CEP78,PLK4,EXOC2,DCTN1,IFT22,CCT2,TMEM67,CSNK1E,BBS5,NEDD1,CEP76,CDK1,YWHAG,ARF4,ARL6,HSPB11,TCP1,CEP250,IFT122,ARL13B,BBIP1,IFT140,TTBK2,TUBB,DCTN3,CEP152,DYNC1I2,DCTN2,BBS4,TRIP11,SEPT2,BBS9,IFT27,RAB11A,CEP164,CEP57,DYNLRB2,CCP110,CEP290,CENPJ,IFT20,WDR60,HSP90AA1,CEP83,IQCB1,IFT43,CDK5RAP2,CCT3,KIF24,IFT74,CEP131,CCT8,BBS12,SCLT1,PCM1,TTC26,ODF2,SDCCAG8,WDR19,EXOC4,OFD1,DYNC2LI1,SSNA1,CEP192,NPHP1
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	3.65561215329167e-10	-21.7295873669618	223	105	0.0461335676625659	2276	8202	23291,90933,9820,7317,84231,55284,23304,55585,9867,5707,5696,5687,8651,197131,10193,51343,79876,10393,51619,54778,23295,51434,64219,26259,140739,7311,991,5695,868,7335,8697,23352,56658,5719,7336,6233,5714,5709,7174,23608,10533,7320,5690,51130,5705,9861,5700,7334,55521,7323,51433,5689,5693,9320,25831,9903,26272,4012,5713,140462,23327,80196,9354,5715,9491,4734,27252,8139,51465,6047,26046,5717,89910,7314,54926,90678,9730,5686,5694,5692,25847,5702,6502,7319,7328,5682,29882,6921,5710,4591,55236,5691,10425,7316,996,8453,7322,51444,27338,23376,10197,9604,11065,8945,63891	FBXW11,TRIM41,CUL7,UBA1,TRAF7,UBE2W,UBR2,UBE2Q1,PJA2,PSMD1,PSMB8,PSMA6,SOCS1,UBR1,RNF41,FZR1,UBA5,ANAPC10,UBE2D4,RNF111,MGRN1,ANAPC7,PJA1,FBXW8,UBE2F,UBA52,CDC20,PSMB7,CBLB,UBE2V1,CDC23,UBR4,TRIM39,PSMD13,UBE2V2,RPS27A,PSMD8,PSMD3,TPP2,MKRN1,ATG7,UBE2B,PSMB2,ASB3,PSMC5,PSMD6,PSMC1,UBE2N,TRIM36,UBE2D3,ANAPC5,PSMB1,PSMB5,TRIP12,HECTD1,KLHL21,FBXO4,LNPEP,PSMD7,ASB9,NEDD4L,RNF34,UBE4A,PSMD9,PSMF1,NEDD4,KLHL20,GAN,UBE2J1,RNF4,LTN1,PSMD11,UBE3B,UBB,UBE2R2,LRSAM1,VPRBP,PSMA5,PSMB6,PSMB4,ANAPC13,PSMC3,SKP2,UBE2A,UBE2H,PSMA1,ANAPC2,TCEB1,PSMD4,TRIM37,UBA6,PSMB3,ARIH2,UBC,CDC27,CUL2,UBE2D2,RNF138,UBE2S,UFL1,PSME3,RNF14,UBE2C,BTRC,RNF123
R-HSA-5368287	Mitochondrial translation	4.9937704213185e-10	-21.417659710041	90	53	0.023286467486819	2276	8202	51373,65080,28977,64960,54148,10102,64949,3396,51263,65993,9801,64963,56945,54534,116540,63875,116541,51642,29088,64951,51253,51650,51258,4528,79590,6182,7284,54516,55173,219402,60488,54948,122704,63931,64979,51318,51081,55052,54460,85476,51069,128308,51649,118487,9553,51264,28957,65008,51021,11222,29074,57129,54998	MRPS17,MRPL44,MRPL42,MRPS15,MRPL39,TSFM,MRPS26,ICT1,MRPL30,MRPS34,MRPL19,MRPS11,MRPS22,MRPL50,MRPL53,MRPL17,MRPL54,MRPL48,MRPL15,MRPS24,MRPL37,MRPS33,MRPL51,MTIF2,MRPL24,MRPL12,TUFM,MTRF1L,MRPS10,MTIF3,MRPS35,MRPL16,MRPL52,MRPS14,MRPL36,MRPL35,MRPS7,MRPL20,MRPS21,GFM1,MRPL2,MRPL55,MRPS23,CHCHD1,MRPL33,MRPL27,MRPS28,MRPL1,MRPS16,MRPL3,MRPL18,MRPL47,AURKAIP1
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	5.15219187513003e-10	-21.3864286989883	102	58	0.0254833040421793	2276	8202	4729,51204,4712,7381,6391,7351,521,54205,506,51079,54539,51241,374291,4709,7386,9997,4723,517,84987,1337,10476,4708,55471,7385,4728,4731,1537,1349,4700,4705,4696,55967,4720,285521,516,10632,1350,51300,27089,1353,514,4701,9551,513,6392,25915,126328,9167,10128,29078,4694,1351,9377,7388,4725,498,4713,1340	NDUFV2,TACO1,NDUFB6,UQCRB,SDHC,UCP2,ATP5I,CYCS,ATP5B,NDUFA13,NDUFB11,COX16,NDUFS7,NDUFB3,UQCRFS1,SCO2,NDUFV1,ATP5G2,COX14,COX6A1,ATP5H,NDUFB2,NDUFAF7,UQCRC2,NDUFS8,NDUFV3,CYC1,COX7B,NDUFA6,NDUFA10,NDUFA3,NDUFA12,NDUFS2,COX18,ATP5G1,ATP5L,COX7C,TIMMDC1,UQCRQ,COX11,ATP5E,NDUFA7,ATP5J2,ATP5D,SDHD,NDUFAF3,NDUFA11,COX7A2L,LRPPRC,NDUFAF4,NDUFA1,COX8A,COX5A,UQCRH,NDUFS5,ATP5A1,NDUFB7,COX6B1
R-HSA-453274	Mitotic G2-G2/M phases	6.01431204417085e-10	-21.2317089604264	117	64	0.0281195079086116	2276	8202	23291,10142,80321,10383,8655,7531,5566,132660,1069,7465,4218,890,5518,84131,10733,1639,7311,902,1454,1871,121441,79959,995,983,7532,4926,7514,11190,6233,5500,84962,203068,55957,22995,11258,1781,4659,1063,10540,984,10844,22897,9702,9738,80184,55835,85378,3320,7314,10426,993,55755,22994,79866,7316,5108,10806,4957,8481,4660,8636,55125,9133,8945	FBXW11,AKAP9,CEP70,TUBB4B,DYNLL1,YWHAE,PRKACA,LIN54,CETN2,WEE1,RAB8A,CCNA2,PPP2R1A,CEP78,PLK4,DCTN1,UBA52,CCNH,CSNK1E,E2F3,NEDD1,CEP76,CDC25C,CDK1,YWHAG,NUMA1,XPO1,CEP250,RPS27A,PPP1CB,AJUBA,TUBB,LIN37,CEP152,DCTN3,DYNC1I2,PPP1R12A,CENPF,DCTN2,CDK11B,TUBGCP2,CEP164,CEP57,CCP110,CEP290,CENPJ,TUBGCP6,HSP90AA1,UBB,TUBGCP3,CDC25A,CDK5RAP2,CEP131,BORA,UBC,PCM1,SDCCAG8,ODF2,OFD1,PPP1R12B,SSNA1,CEP192,CCNB2,BTRC
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	6.15207619189019e-10	-21.2090613129162	81	49	0.0215289982425308	2276	8202	11258,22995,23291,1781,10142,80321,4659,10383,8655,10540,7531,5566,9702,22897,1069,4218,9738,80184,5518,55835,84131,10733,3320,7314,1639,7311,1454,55755,121441,79959,22994,79866,983,7316,7532,5108,11190,6233,4957,10806,8481,5500,4660,84962,8636,55125,9133,8945,203068	DCTN3,CEP152,FBXW11,DYNC1I2,AKAP9,CEP70,PPP1R12A,TUBB4B,DYNLL1,DCTN2,YWHAE,PRKACA,CEP57,CEP164,CETN2,RAB8A,CCP110,CEP290,PPP2R1A,CENPJ,CEP78,PLK4,HSP90AA1,UBB,DCTN1,UBA52,CSNK1E,CDK5RAP2,NEDD1,CEP76,CEP131,BORA,CDK1,UBC,YWHAG,PCM1,CEP250,RPS27A,ODF2,SDCCAG8,OFD1,PPP1CB,PPP1R12B,AJUBA,SSNA1,CEP192,CCNB2,BTRC,TUBB
R-HSA-69275	G2/M Transition	7.55019455452653e-10	-21.0042775982001	115	63	0.0276801405975395	2276	8202	11258,22995,23291,1781,10142,80321,4659,10383,8655,10540,1063,7531,984,5566,10844,132660,9702,22897,1069,7465,4218,890,9738,80184,5518,55835,84131,85378,10733,3320,7314,10426,1639,993,7311,902,1454,55755,121441,79959,22994,79866,995,983,7532,7316,4926,5108,7514,11190,6233,4957,10806,8481,5500,4660,84962,8636,55125,9133,203068,8945,55957	DCTN3,CEP152,FBXW11,DYNC1I2,AKAP9,CEP70,PPP1R12A,TUBB4B,DYNLL1,DCTN2,CENPF,YWHAE,CDK11B,PRKACA,TUBGCP2,LIN54,CEP57,CEP164,CETN2,WEE1,RAB8A,CCNA2,CCP110,CEP290,PPP2R1A,CENPJ,CEP78,TUBGCP6,PLK4,HSP90AA1,UBB,TUBGCP3,DCTN1,CDC25A,UBA52,CCNH,CSNK1E,CDK5RAP2,NEDD1,CEP76,CEP131,BORA,CDC25C,CDK1,YWHAG,UBC,NUMA1,PCM1,XPO1,CEP250,RPS27A,ODF2,SDCCAG8,OFD1,PPP1CB,PPP1R12B,AJUBA,SSNA1,CEP192,CCNB2,TUBB,BTRC,LIN37
R-HSA-5389840	Mitochondrial translation elongation	9.17662596990036e-10	-20.8091913342731	84	50	0.0219683655536028	2276	8202	51373,65080,28977,64960,54148,10102,64949,3396,51263,65993,9801,64963,56945,54534,116540,63875,116541,51642,29088,64951,51253,51650,51258,79590,6182,7284,55173,60488,54948,122704,63931,64979,51318,51081,55052,54460,85476,51069,128308,51649,118487,9553,51264,28957,65008,51021,11222,29074,57129,54998	MRPS17,MRPL44,MRPL42,MRPS15,MRPL39,TSFM,MRPS26,ICT1,MRPL30,MRPS34,MRPL19,MRPS11,MRPS22,MRPL50,MRPL53,MRPL17,MRPL54,MRPL48,MRPL15,MRPS24,MRPL37,MRPS33,MRPL51,MRPL24,MRPL12,TUFM,MRPS10,MRPS35,MRPL16,MRPL52,MRPS14,MRPL36,MRPL35,MRPS7,MRPL20,MRPS21,GFM1,MRPL2,MRPL55,MRPS23,CHCHD1,MRPL33,MRPL27,MRPS28,MRPL1,MRPS16,MRPL3,MRPL18,MRPL47,AURKAIP1
R-HSA-68874	M/G1 Transition	1.12036747823179e-09	-20.6096090998902	82	49	0.0215289982425308	2276	8202	23649,5689,4175,5693,55388,5713,4998,5715,4176,9491,4173,6118,5707,5687,5696,4174,5717,23595,7314,5686,5694,4999,7311,5692,5422,5702,5695,1871,5682,990,5710,4171,5691,7316,8318,5000,5719,6233,5714,5709,5001,84515,5690,10197,9861,5705,1870,5700,4172	POLA2,PSMB1,MCM6,PSMB5,MCM10,PSMD7,ORC1,PSMD9,MCM7,PSMF1,MCM4,RPA2,PSMD1,PSMA6,PSMB8,MCM5,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,POLA1,PSMC3,PSMB7,E2F3,PSMA1,CDC6,PSMD4,MCM2,PSMB3,UBC,CDC45,ORC4,PSMD13,RPS27A,PSMD8,PSMD3,ORC5,MCM8,PSMB2,PSME3,PSMD6,PSMC5,E2F2,PSMC1,MCM3
R-HSA-69002	DNA Replication Pre-Initiation	1.12036747823179e-09	-20.6096090998902	82	49	0.0215289982425308	2276	8202	23649,5689,4175,5693,55388,5713,4998,5715,4176,9491,4173,6118,5707,5687,5696,4174,5717,23595,7314,5686,5694,4999,7311,5692,5422,5702,5695,1871,5682,990,5710,4171,5691,7316,8318,5000,5719,6233,5714,5709,5001,84515,5690,10197,9861,5705,1870,5700,4172	POLA2,PSMB1,MCM6,PSMB5,MCM10,PSMD7,ORC1,PSMD9,MCM7,PSMF1,MCM4,RPA2,PSMD1,PSMA6,PSMB8,MCM5,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,POLA1,PSMC3,PSMB7,E2F3,PSMA1,CDC6,PSMD4,MCM2,PSMB3,UBC,CDC45,ORC4,PSMD13,RPS27A,PSMD8,PSMD3,ORC5,MCM8,PSMB2,PSME3,PSMD6,PSMC5,E2F2,PSMC1,MCM3
R-HSA-5696398	Nucleotide Excision Repair	1.49062187730895e-09	-20.3240724367411	109	60	0.0263620386643234	2276	8202	5440,57461,2071,54617,56949,3978,7329,5424,7341,5886,6118,1069,8178,5111,51138,2968,8533,5887,57654,54778,2965,79913,6917,2068,125476,9716,7314,57804,5431,27339,2067,1643,5984,3150,7311,5983,902,9318,10038,10714,5982,7515,7316,5430,5432,50813,8607,7336,2074,6233,10987,5434,29844,2073,5981,91603,7334,86,5425,1642	POLR2K,ISY1,ERCC3,INO80,XAB2,LIG1,UBE2I,POLD1,SUMO1,RAD23A,RPA2,CETN2,ELL,PCNA,COPS4,GTF2H4,COPS3,RAD23B,UVSSA,RNF111,GTF2H1,ACTR5,TCEA1,ERCC2,INO80C,AQR,UBB,POLD4,POLR2B,PRPF19,ERCC1,DDB2,RFC4,HMGN1,UBA52,RFC3,CCNH,COPS2,PARP2,POLD3,RFC2,XRCC1,UBC,POLR2A,POLR2C,COPS7A,RUVBL1,UBE2V2,ERCC6,RPS27A,COPS5,POLR2E,TFPT,ERCC5,RFC1,ZNF830,UBE2N,ACTL6A,POLD2,DDB1
R-HSA-69206	G1/S Transition	1.49062187730895e-09	-20.3240724367411	109	60	0.0263620386643234	2276	8202	23649,5689,4175,5693,55388,5713,4998,5715,4176,9491,26271,4173,6118,7465,5111,5707,5687,890,5696,5518,4174,4609,1163,1027,5717,23595,7314,5686,5694,993,4999,7311,902,5692,5422,5702,6502,5695,5682,6241,990,5710,4171,983,5691,7316,8318,5000,5719,6233,5714,5709,5001,84515,5690,9861,10197,5705,5700,4172	POLA2,PSMB1,MCM6,PSMB5,MCM10,PSMD7,ORC1,PSMD9,MCM7,PSMF1,FBXO5,MCM4,RPA2,WEE1,PCNA,PSMD1,PSMA6,CCNA2,PSMB8,PPP2R1A,MCM5,MYC,CKS1B,CDKN1B,PSMD11,ORC3,UBB,PSMA5,PSMB6,CDC25A,ORC2,UBA52,CCNH,PSMB4,POLA1,PSMC3,SKP2,PSMB7,PSMA1,RRM2,CDC6,PSMD4,MCM2,CDK1,PSMB3,UBC,CDC45,ORC4,PSMD13,RPS27A,PSMD8,PSMD3,ORC5,MCM8,PSMB2,PSMD6,PSME3,PSMC5,PSMC1,MCM3
R-HSA-212436	Generic Transcription Pathway	1.62830801787085e-09	-20.2357243870958	553	216	0.0949033391915641	2276	8202	51204,7745,5565,127396,285268,10001,7692,7531,79898,51241,125919,162239,7587,9997,80108,1490,22869,7752,284459,54778,5494,349075,163081,7551,23660,285521,64223,80110,84124,7311,2649,208,9442,147929,5571,199692,8239,6009,6498,2744,10781,55663,6233,115509,7768,9377,10795,9282,7596,93474,1340,7323,57343,219749,5562,4092,7762,23327,400720,54205,7699,10062,7633,1482,54541,9668,57103,112950,84246,4609,94039,9862,55657,92285,9443,9794,25799,58500,54811,342132,5915,170959,7574,199704,91975,2100,7025,79027,6257,155054,7248,51422,10127,9167,389541,51586,221785,4929,7534,6907,2101,163049,388567,29959,7571,79744,79088,5564,51123,353355,146434,2475,147694,51276,1875,55659,7157,92595,29079,79818,7695,147923,285971,25888,55900,9441,7586,84987,28956,730087,7539,7769,9572,10794,90390,7181,26152,284370,1350,5914,57711,29982,26048,79759,80032,1353,10971,7556,10025,7697,7728,10155,7532,7421,121274,152687,90874,5933,80139,283337,197320,4306,51385,1030,201514,169841,7673,51058,7376,7755,168374,7988,147687,57209,93134,1337,3726,7565,344787,1349,7314,146540,55778,147837,83744,6667,7296,7050,9439,1024,2908,3164,7003,7753,79862,115196,204851,148206,55422,5052,7316,7638,148254,51592,5467,7733,80778,58492,22835,65988,10128,126231,1351,8013,3516,7533	TACO1,ZKSCAN8,PRKAB2,ZNF684,ZNF621,MED6,ZNF133,YWHAE,ZNF613,COX16,ZNF543,ZFP1,ZNF37A,SCO2,ZFP2,CTGF,ZNF510,ZNF200,HKR1,RNF111,PPM1A,ZNF713,ZNF567,ZNF3,ZKSCAN5,COX18,MLST8,ZNF614,ZNF394,UBA52,NR6A1,AKT2,MED27,ZNF565,PRKAG1,ZNF627,USP9X,RHEB,SKIL,GLS,ZNF266,ZNF446,RPS27A,ZNF689,ZNF225,COX5A,ZNF268,MED14,ZNF45,ZNF670,COX6B1,UBE2D3,ZNF304,ZNF25,PRKAA1,SMAD7,ZNF215,NEDD4L,ZNF772,CYCS,ZNF140,NR1H3,ZNF79,NKX2-5,DDIT4,ZNF432,TIGAR,MED8,MED10,MYC,ZNF101,MED24,ZNF692,ZNF585B,MED7,MAML1,ZNF324,ZNF250,ZNF562,ZNF774,RARB,ZNF431,ZNF26,ZNF585A,ZNF300,ESR2,NR2F1,ZNF655,RXRB,ZNF425,TSC1,PRKAG2,ZNF263,COX7A2L,LAMTOR4,MED15,ZSCAN25,NR4A2,YWHAZ,TBL1X,ESRRA,ZNF791,ZNF749,NRBP1,ZNF23,ZNF419,ZNF426,PRKAB1,ZNF706,ZNF233,ZNF597,MTOR,ZNF548,ZNF571,E2F5,ZNF416,TP53,ZNF764,MED4,ZNF552,ZNF136,ZNF420,ZNF775,ZNF473,ZNF302,MED26,ZKSCAN1,COX14,LAMTOR2,ZNF726,ZFP37,ZNF226,NR1D1,ZNF460,MED30,NR2C1,ZNF337,ZNF615,COX7C,RARA,ZNF529,NRBF2,ZNF500,ZNF668,ZNF556,COX11,YWHAQ,ZNF10,MED16,ZNF138,ZNF175,TRIM28,YWHAG,VDR,ZNF641,ZNF595,ZNF697,RBL1,ZNF703,ZNF740,ZNF778,NR3C2,ZNF589,CDKN2B,ZNF584,ZNF169,ZNF222,ZNF691,NR1H2,ZNF205,ZNF92,ZNF212,ZNF417,ZNF248,ZNF561,COX6A1,JUNB,ZNF17,ZNF860,COX7B,UBB,ZNF785,ZNF839,ZNF563,ZNF484,SP1,TXNRD1,TGIF1,MED23,CDK8,NR3C1,NR4A1,TEAD1,ZNF202,ZNF669,ZNF554,HIPK1,ZNF714,ZNF331,PRDX1,UBC,ZNF221,ZNF555,TRIM33,PPARD,ZNF180,ZNF34,ZNF77,ZFP30,ZNF747,LRPPRC,ZNF573,COX8A,NR4A3,RBPJ,YWHAH
R-HSA-176187	Activation of ATR in response to replication stress	1.77488009623863e-09	-20.1495329677156	37	28	0.0123022847100176	2276	8202	5883,993,5984,4999,4175,5983,55388,5810,144715,1111,990,5884,4998,4171,5982,995,4176,8318,6118,4173,5000,4174,5001,84515,84126,545,23595,4172	RAD9A,CDC25A,RFC4,ORC2,MCM6,RFC3,MCM10,RAD1,RAD9B,CHEK1,CDC6,RAD17,ORC1,MCM2,RFC2,CDC25C,MCM7,CDC45,RPA2,MCM4,ORC4,MCM5,ORC5,MCM8,ATRIP,ATR,ORC3,MCM3
R-HSA-73857	RNA Polymerase II Transcription	1.86858807579044e-09	-20.0980827309502	107	59	0.0259226713532513	2276	8202	9150,6884,5440,6872,6908,2071,6431,10250,9939,10978,6635,2962,8178,25888,10189,2968,83860,6429,2963,2965,6882,6917,2068,2960,2959,51692,84967,5431,1477,11338,6881,6877,902,7936,8731,10921,7884,6921,51585,6430,7469,2958,6875,6829,5430,6426,11198,6873,5432,4686,11051,7307,5434,1478,6637,6883,6428,6878,9785	CTDP1,TAF13,POLR2K,TAF1,TBP,ERCC3,SRSF6,SRRM1,RBM8A,CLP1,SNRPE,GTF2F1,ELL,ZNF473,ALYREF,GTF2H4,TAF3,SRSF4,GTF2F2,GTF2H1,TAF11,TCEA1,ERCC2,GTF2E1,GTF2B,CPSF3,LSM10,POLR2B,CSTF1,U2AF2,TAF10,TAF5,CCNH,NELFE,RNMT,RNPS1,SLBP,TCEB1,PCF11,SRSF5,NELFA,GTF2A2,TAF4B,SUPT5H,POLR2A,SRSF1,SUPT16H,TAF2,POLR2C,NCBP1,NUDT21,U2AF1,POLR2E,CSTF2,SNRPG,TAF12,SRSF3,TAF6,DHX38
R-HSA-2467813	Separation of Sister Chromatids	2.12540294947181e-09	-19.9693044292654	161	80	0.0351493848857645	2276	8202	9232,5526,11004,79003,9183,5707,5687,5696,5518,55746,10393,8379,51434,1058,7311,348235,991,5695,701,6232,9212,8697,79682,3796,5903,5529,7514,79980,25936,5719,6233,5714,5709,4085,8243,5690,5527,23122,5705,9861,151648,5700,5528,51433,5689,6396,5693,1063,5713,55143,55055,5715,9491,91687,79172,151246,5717,9735,79019,7314,5686,5694,10726,11130,5692,10274,5702,5682,29882,5710,5691,7316,401541,996,332,147841,1062,10197,57082,11065	PTTG1,PPP2R5B,KIF2C,MIS12,ZW10,PSMD1,PSMA6,PSMB8,PPP2R1A,NUP133,ANAPC10,MAD1L1,ANAPC7,CENPA,UBA52,SKA2,CDC20,PSMB7,BUB1B,RPS27,AURKB,CDC23,CENPU,KIF2A,RANBP2,PPP2R5E,XPO1,DSN1,NSL1,PSMD13,RPS27A,PSMD8,PSMD3,MAD2L1,SMC1A,PSMB2,PPP2R5C,CLASP2,PSMC5,PSMD6,SGOL1,PSMC1,PPP2R5D,ANAPC5,PSMB1,SEC13,PSMB5,CENPF,PSMD7,CDCA8,ZWILCH,PSMD9,PSMF1,CENPL,CENPO,SGOL2,PSMD11,KNTC1,CENPM,UBB,PSMA5,PSMB6,NUDC,ZWINT,PSMB4,STAG1,PSMC3,PSMA1,ANAPC2,PSMD4,PSMB3,UBC,CENPP,CDC27,BIRC5,SPC24,CENPE,PSME3,CASC5,UBE2C
R-HSA-69481	G2/M Checkpoints	2.34145514185036e-09	-19.8724932453572	105	58	0.0254833040421793	2276	8202	5883,4175,55388,8367,29086,144715,1111,4998,7531,4176,8347,8360,7341,8365,4173,6118,7465,4174,8364,84126,545,23595,3017,993,5984,4999,5810,5983,85236,10971,990,9025,5884,8340,8363,4171,8368,5982,995,983,7532,8318,8362,5000,7336,7158,5001,84515,3014,51720,7534,165918,11200,128312,7533,9133,7334,4172	RAD9A,MCM6,MCM10,HIST1H4E,BABAM1,RAD9B,CHEK1,ORC1,YWHAE,MCM7,HIST1H2BC,HIST1H4D,SUMO1,HIST1H4H,MCM4,RPA2,WEE1,MCM5,HIST1H4C,ATRIP,ATR,ORC3,HIST1H2BD,CDC25A,RFC4,ORC2,RAD1,RFC3,HIST1H2BK,YWHAQ,CDC6,RNF8,RAD17,HIST1H2BL,HIST1H4J,MCM2,HIST1H4L,RFC2,CDC25C,CDK1,YWHAG,CDC45,HIST1H4K,ORC4,UBE2V2,TP53BP1,ORC5,MCM8,H2AFX,UIMC1,YWHAZ,RNF168,CHEK2,HIST3H2BB,YWHAH,CCNB2,UBE2N,MCM3
R-HSA-5368286	Mitochondrial translation initiation	3.52620338211712e-09	-19.463044073943	84	49	0.0215289982425308	2276	8202	51373,65080,28977,64960,54148,64949,3396,51263,65993,9801,64963,56945,54534,116540,63875,116541,51642,29088,64951,51253,51650,51258,4528,79590,6182,55173,219402,60488,54948,122704,63931,64979,51318,51081,55052,54460,51069,128308,51649,118487,9553,51264,28957,65008,51021,11222,29074,57129,54998	MRPS17,MRPL44,MRPL42,MRPS15,MRPL39,MRPS26,ICT1,MRPL30,MRPS34,MRPL19,MRPS11,MRPS22,MRPL50,MRPL53,MRPL17,MRPL54,MRPL48,MRPL15,MRPS24,MRPL37,MRPS33,MRPL51,MTIF2,MRPL24,MRPL12,MRPS10,MTIF3,MRPS35,MRPL16,MRPL52,MRPS14,MRPL36,MRPL35,MRPS7,MRPL20,MRPS21,MRPL2,MRPL55,MRPS23,CHCHD1,MRPL33,MRPL27,MRPS28,MRPL1,MRPS16,MRPL3,MRPL18,MRPL47,AURKAIP1
R-HSA-453276	Regulation of mitotic cell cycle	7.54955752471168e-09	-18.7017768814013	83	48	0.0210896309314587	2276	8202	51433,5689,5693,9232,5713,5715,9491,26271,5707,5687,890,5696,51343,10393,5717,51434,7314,5686,5694,7311,5692,5702,991,6502,5695,5682,29882,701,9212,8697,5710,983,5691,7316,5719,996,6233,5714,5709,4085,5690,10197,9861,5705,11065,8556,5700,8945	ANAPC5,PSMB1,PSMB5,PTTG1,PSMD7,PSMD9,PSMF1,FBXO5,PSMD1,PSMA6,CCNA2,PSMB8,FZR1,ANAPC10,PSMD11,ANAPC7,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,SKP2,PSMB7,PSMA1,ANAPC2,BUB1B,AURKB,CDC23,PSMD4,CDK1,PSMB3,UBC,PSMD13,CDC27,RPS27A,PSMD8,PSMD3,MAD2L1,PSMB2,PSME3,PSMD6,PSMC5,UBE2C,CDC14A,PSMC1,BTRC
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	7.54955752471168e-09	-18.7017768814013	83	48	0.0210896309314587	2276	8202	51433,5689,5693,9232,5713,5715,9491,26271,5707,5687,890,5696,51343,10393,5717,51434,7314,5686,5694,7311,5692,5702,991,6502,5695,5682,29882,701,9212,8697,5710,983,5691,7316,5719,996,6233,5714,5709,4085,5690,10197,9861,5705,11065,8556,5700,8945	ANAPC5,PSMB1,PSMB5,PTTG1,PSMD7,PSMD9,PSMF1,FBXO5,PSMD1,PSMA6,CCNA2,PSMB8,FZR1,ANAPC10,PSMD11,ANAPC7,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,SKP2,PSMB7,PSMA1,ANAPC2,BUB1B,AURKB,CDC23,PSMD4,CDK1,PSMB3,UBC,PSMD13,CDC27,RPS27A,PSMD8,PSMD3,MAD2L1,PSMB2,PSME3,PSMD6,PSMC5,UBE2C,CDC14A,PSMC1,BTRC
R-HSA-611105	Respiratory electron transport	9.32895583912172e-09	-18.4901427426993	81	47	0.0206502636203866	2276	8202	4729,51204,4712,7381,6391,54205,51079,54539,51241,374291,4709,7386,9997,4723,84987,1337,4708,55471,7385,4728,4731,1537,1349,4700,4705,4696,55967,4720,285521,1350,51300,27089,1353,4701,6392,25915,126328,9167,10128,29078,4694,1351,9377,7388,4725,4713,1340	NDUFV2,TACO1,NDUFB6,UQCRB,SDHC,CYCS,NDUFA13,NDUFB11,COX16,NDUFS7,NDUFB3,UQCRFS1,SCO2,NDUFV1,COX14,COX6A1,NDUFB2,NDUFAF7,UQCRC2,NDUFS8,NDUFV3,CYC1,COX7B,NDUFA6,NDUFA10,NDUFA3,NDUFA12,NDUFS2,COX18,COX7C,TIMMDC1,UQCRQ,COX11,NDUFA7,SDHD,NDUFAF3,NDUFA11,COX7A2L,LRPPRC,NDUFAF4,NDUFA1,COX8A,COX5A,UQCRH,NDUFS5,NDUFB7,COX6B1
R-HSA-5419276	Mitochondrial translation termination	1.29140297148534e-08	-18.164951541765	84	48	0.0210896309314587	2276	8202	51373,65080,28977,64960,54148,64949,3396,51263,65993,9801,64963,56945,54534,116540,63875,116541,51642,29088,64951,51253,51650,51258,79590,6182,54516,55173,60488,54948,122704,63931,64979,51318,51081,55052,54460,51069,128308,51649,118487,9553,51264,28957,65008,51021,11222,29074,57129,54998	MRPS17,MRPL44,MRPL42,MRPS15,MRPL39,MRPS26,ICT1,MRPL30,MRPS34,MRPL19,MRPS11,MRPS22,MRPL50,MRPL53,MRPL17,MRPL54,MRPL48,MRPL15,MRPS24,MRPL37,MRPS33,MRPL51,MRPL24,MRPL12,MTRF1L,MRPS10,MRPS35,MRPL16,MRPL52,MRPS14,MRPL36,MRPL35,MRPS7,MRPL20,MRPS21,MRPL2,MRPL55,MRPS23,CHCHD1,MRPL33,MRPL27,MRPS28,MRPL1,MRPS16,MRPL3,MRPL18,MRPL47,AURKAIP1
R-HSA-162587	HIV Life Cycle	1.55356398116356e-08	-17.9801291097782	140	70	0.0307557117750439	2276	8202	27243,23511,2071,2968,55746,9972,6917,6882,2237,6881,6877,7311,902,8731,9525,9631,2958,25978,8021,11198,6873,5432,5903,7514,6233,2547,7251,8086,4836,6884,9150,6908,5440,6872,8480,51534,53371,3978,23327,129401,5478,23165,2962,8178,4927,83860,2963,2965,2068,2960,7314,2959,5431,7936,6921,51652,6829,6875,7469,7316,5430,7520,4686,79720,5434,23636,3159,6883,6878,9818	CHMP2A,NUP188,ERCC3,GTF2H4,NUP133,NUP153,TCEA1,TAF11,FEN1,TAF10,TAF5,UBA52,CCNH,RNMT,VPS4B,NUP155,GTF2A2,CHMP2B,NUP214,SUPT16H,TAF2,POLR2C,RANBP2,XPO1,RPS27A,XRCC6,TSG101,AAAS,NMT1,TAF13,CTDP1,TBP,POLR2K,TAF1,RAE1,VTA1,NUP54,LIG1,NEDD4L,NUP35,PPIA,NUP205,GTF2F1,ELL,NUP88,TAF3,GTF2F2,GTF2H1,ERCC2,GTF2E1,UBB,GTF2B,POLR2B,NELFE,TCEB1,CHMP3,SUPT5H,TAF4B,NELFA,UBC,POLR2A,XRCC5,NCBP1,VPS37B,POLR2E,NUP62,HMGA1,TAF12,TAF6,NUP58
R-HSA-162599	Late Phase of HIV Life Cycle	1.57195291329089e-08	-17.9683620037713	127	65	0.0285588752196837	2276	8202	27243,23511,2071,2968,55746,9972,6917,6882,6881,6877,7311,902,8731,9525,9631,2958,25978,8021,11198,6873,5432,5903,7514,6233,7251,8086,4836,6884,9150,6908,5440,6872,51534,8480,53371,23327,129401,5478,23165,2962,8178,4927,83860,2963,2965,2068,2960,7314,2959,5431,7936,6921,6829,6875,7469,51652,7316,5430,4686,79720,5434,23636,6883,6878,9818	CHMP2A,NUP188,ERCC3,GTF2H4,NUP133,NUP153,TCEA1,TAF11,TAF10,TAF5,UBA52,CCNH,RNMT,VPS4B,NUP155,GTF2A2,CHMP2B,NUP214,SUPT16H,TAF2,POLR2C,RANBP2,XPO1,RPS27A,TSG101,AAAS,NMT1,TAF13,CTDP1,TBP,POLR2K,TAF1,VTA1,RAE1,NUP54,NEDD4L,NUP35,PPIA,NUP205,GTF2F1,ELL,NUP88,TAF3,GTF2F2,GTF2H1,ERCC2,GTF2E1,UBB,GTF2B,POLR2B,NELFE,TCEB1,SUPT5H,TAF4B,NELFA,CHMP3,UBC,POLR2A,NCBP1,VPS37B,POLR2E,NUP62,TAF12,TAF6,NUP58
R-HSA-429914	Deadenylation-dependent mRNA decay	1.83739193555633e-08	-17.8123336041585	50	33	0.0144991212653779	2276	8202	23019,9337,196513,25804,29883,85456,55571,9924,4849,80153,23016,23658,9775,11340,55802,54512,27257,1977,26986,23404,118460,1975,1974,23644,1973,5393,219988,167227,9125,4848,25904,27258,54464	CNOT1,CNOT8,DCP1B,LSM4,CNOT7,TNKS1BP1,CNOT11,PAN2,CNOT3,EDC3,EXOSC7,LSM5,EIF4A3,EXOSC8,DCP1A,EXOSC4,LSM1,EIF4E,PABPC1,EXOSC2,EXOSC6,EIF4B,EIF4A2,EDC4,EIF4A1,EXOSC9,PATL1,DCP2,RQCD1,CNOT2,CNOT10,LSM3,XRN1
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	3.22693713789646e-08	-17.2491473111168	69	41	0.0180140597539543	2276	8202	51433,5689,5693,5713,5715,9491,5707,5687,890,5696,10393,5717,51434,7314,5686,5694,7311,5692,5702,991,5695,5682,29882,701,8697,5710,983,5691,7316,996,5719,6233,5709,5714,4085,5690,10197,9861,5705,11065,5700	ANAPC5,PSMB1,PSMB5,PSMD7,PSMD9,PSMF1,PSMD1,PSMA6,CCNA2,PSMB8,ANAPC10,PSMD11,ANAPC7,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,PSMA1,ANAPC2,BUB1B,CDC23,PSMD4,CDK1,PSMB3,UBC,CDC27,PSMD13,RPS27A,PSMD3,PSMD8,MAD2L1,PSMB2,PSME3,PSMD6,PSMC5,UBE2C,PSMC1
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	3.22693713789646e-08	-17.2491473111168	69	41	0.0180140597539543	2276	8202	51433,5689,5693,9232,5713,5715,9491,5707,5687,5696,51343,10393,5717,51434,7314,5686,5694,7311,5692,5702,991,6502,5695,5682,29882,9212,8697,5710,5691,7316,996,5719,6233,5709,5714,5690,10197,9861,5705,11065,5700	ANAPC5,PSMB1,PSMB5,PTTG1,PSMD7,PSMD9,PSMF1,PSMD1,PSMA6,PSMB8,FZR1,ANAPC10,PSMD11,ANAPC7,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,SKP2,PSMB7,PSMA1,ANAPC2,AURKB,CDC23,PSMD4,PSMB3,UBC,CDC27,PSMD13,RPS27A,PSMD3,PSMD8,PSMB2,PSME3,PSMD6,PSMC5,UBE2C,PSMC1
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	3.81096971508536e-08	-17.082797068803	60	37	0.0162565905096661	2276	8202	51433,5689,5693,5713,5715,9491,5707,5687,5696,51343,10393,5717,51434,7314,5686,5694,7311,5692,5702,5695,5682,29882,5710,8697,7316,5691,996,5719,6233,5709,5714,5690,5705,10197,9861,11065,5700	ANAPC5,PSMB1,PSMB5,PSMD7,PSMD9,PSMF1,PSMD1,PSMA6,PSMB8,FZR1,ANAPC10,PSMD11,ANAPC7,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,ANAPC2,PSMD4,CDC23,UBC,PSMB3,CDC27,PSMD13,RPS27A,PSMD3,PSMD8,PSMB2,PSMC5,PSME3,PSMD6,UBE2C,PSMC1
R-HSA-68827	CDT1 association with the CDC6:ORC:origin complex	4.570588760699e-08	-16.9010387156815	58	36	0.015817223198594	2276	8202	5689,5693,5713,4998,5715,9491,5707,5687,5696,5717,23595,7314,5686,5694,4999,7311,5692,5702,5695,5682,990,5710,7316,5691,5719,5000,6233,5709,5714,5001,84515,5690,5705,10197,9861,5700	PSMB1,PSMB5,PSMD7,ORC1,PSMD9,PSMF1,PSMD1,PSMA6,PSMB8,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,CDC6,PSMD4,UBC,PSMB3,PSMD13,ORC4,RPS27A,PSMD3,PSMD8,ORC5,MCM8,PSMB2,PSMC5,PSME3,PSMD6,PSMC1
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	4.63869271061831e-08	-16.8862481608126	72	42	0.0184534270650264	2276	8202	51433,5689,5693,9232,5713,5715,9491,5707,5687,890,5696,10393,5717,51434,7314,5686,5694,7311,5692,5702,991,5695,5682,29882,701,8697,5710,983,5691,7316,996,5719,6233,5714,5709,4085,5690,10197,9861,5705,11065,5700	ANAPC5,PSMB1,PSMB5,PTTG1,PSMD7,PSMD9,PSMF1,PSMD1,PSMA6,CCNA2,PSMB8,ANAPC10,PSMD11,ANAPC7,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,PSMA1,ANAPC2,BUB1B,CDC23,PSMD4,CDK1,PSMB3,UBC,CDC27,PSMD13,RPS27A,PSMD8,PSMD3,MAD2L1,PSMB2,PSME3,PSMD6,PSMC5,UBE2C,PSMC1
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	5.20800260296322e-08	-16.7704843392453	77	44	0.0193321616871705	2276	8202	5440,57461,2071,56949,3978,5424,6118,8178,5111,51138,2968,8533,57654,2965,6917,2068,9716,7314,57804,5431,27339,2067,5984,3150,7311,5983,902,9318,10714,5982,7515,5430,7316,5432,50813,6233,2074,10987,5434,2073,5981,91603,1642,5425	POLR2K,ISY1,ERCC3,XAB2,LIG1,POLD1,RPA2,ELL,PCNA,COPS4,GTF2H4,COPS3,UVSSA,GTF2H1,TCEA1,ERCC2,AQR,UBB,POLD4,POLR2B,PRPF19,ERCC1,RFC4,HMGN1,UBA52,RFC3,CCNH,COPS2,POLD3,RFC2,XRCC1,POLR2A,UBC,POLR2C,COPS7A,RPS27A,ERCC6,COPS5,POLR2E,ERCC5,RFC1,ZNF830,DDB1,POLD2
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	5.20800260296322e-08	-16.7704843392453	77	44	0.0193321616871705	2276	8202	51433,5689,5693,5713,5715,9491,26271,5707,5687,890,5696,51343,10393,5717,51434,7314,5686,5694,7311,5692,5702,991,5695,5682,29882,701,8697,5710,983,5691,7316,996,5719,6233,5714,5709,4085,5690,10197,9861,5705,11065,5700,8945	ANAPC5,PSMB1,PSMB5,PSMD7,PSMD9,PSMF1,FBXO5,PSMD1,PSMA6,CCNA2,PSMB8,FZR1,ANAPC10,PSMD11,ANAPC7,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,PSMA1,ANAPC2,BUB1B,CDC23,PSMD4,CDK1,PSMB3,UBC,CDC27,PSMD13,RPS27A,PSMD8,PSMD3,MAD2L1,PSMB2,PSME3,PSMD6,PSMC5,UBE2C,PSMC1,BTRC
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	5.71533511167457e-08	-16.6775278112113	70	41	0.0180140597539543	2276	8202	51433,5689,5693,5713,5715,9491,5707,5687,890,5696,10393,5717,51434,7314,5686,5694,7311,5692,5702,991,5695,5682,29882,701,8697,5710,983,5691,7316,996,5719,6233,5709,5714,4085,5690,10197,9861,5705,11065,5700	ANAPC5,PSMB1,PSMB5,PSMD7,PSMD9,PSMF1,PSMD1,PSMA6,CCNA2,PSMB8,ANAPC10,PSMD11,ANAPC7,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,PSMA1,ANAPC2,BUB1B,CDC23,PSMD4,CDK1,PSMB3,UBC,CDC27,PSMD13,RPS27A,PSMD3,PSMD8,MAD2L1,PSMB2,PSME3,PSMD6,PSMC5,UBE2C,PSMC1
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	5.90314045344092e-08	-16.6451962544073	87	48	0.0210896309314587	2276	8202	5689,5693,5713,5715,9491,5707,5687,23016,5696,11340,55802,3184,8125,5717,54512,7314,26986,5686,5694,23404,7311,118460,5692,3312,5702,5695,5682,5393,5710,8021,5691,167227,7316,3304,7514,5719,1994,6233,5714,5709,5690,8570,7534,54464,9861,10197,5705,5700	PSMB1,PSMB5,PSMD7,PSMD9,PSMF1,PSMD1,PSMA6,EXOSC7,PSMB8,EXOSC8,DCP1A,HNRNPD,ANP32A,PSMD11,EXOSC4,UBB,PABPC1,PSMA5,PSMB6,EXOSC2,UBA52,EXOSC6,PSMB4,HSPA8,PSMC3,PSMB7,PSMA1,EXOSC9,PSMD4,NUP214,PSMB3,DCP2,UBC,HSPA1B,XPO1,PSMD13,ELAVL1,RPS27A,PSMD8,PSMD3,PSMB2,KHSRP,YWHAZ,XRN1,PSMD6,PSME3,PSMC5,PSMC1
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	7.57864864552936e-08	-16.3953458391456	90	49	0.0215289982425308	2276	8202	11258,26123,22995,1781,10142,261734,80321,10383,8655,10540,54903,7531,4735,5566,8766,22897,9702,1069,4218,9738,5518,80184,55835,84131,10733,3320,1639,51134,91147,9657,1454,55755,347240,121441,22994,79959,983,7532,132320,5108,11190,4957,10806,8481,8636,146057,55125,4867,203068	DCTN3,TCTN3,CEP152,DYNC1I2,AKAP9,NPHP4,CEP70,TUBB4B,DYNLL1,DCTN2,MKS1,YWHAE,SEPT2,PRKACA,RAB11A,CEP164,CEP57,CETN2,RAB8A,CCP110,PPP2R1A,CEP290,CENPJ,CEP78,PLK4,HSP90AA1,DCTN1,CEP83,TMEM67,IQCB1,CSNK1E,CDK5RAP2,KIF24,NEDD1,CEP131,CEP76,CDK1,YWHAG,SCLT1,PCM1,CEP250,ODF2,SDCCAG8,OFD1,SSNA1,TTBK2,CEP192,NPHP1,TUBB
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	8.01448854075494e-08	-16.3394297726837	73	42	0.0184534270650264	2276	8202	51433,5689,5693,9232,5713,5715,9491,5707,5687,890,5696,10393,5717,51434,7314,5686,5694,7311,5692,5702,991,5695,5682,29882,701,8697,5710,983,5691,7316,996,5719,6233,5714,5709,4085,5690,10197,9861,5705,11065,5700	ANAPC5,PSMB1,PSMB5,PTTG1,PSMD7,PSMD9,PSMF1,PSMD1,PSMA6,CCNA2,PSMB8,ANAPC10,PSMD11,ANAPC7,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,PSMA1,ANAPC2,BUB1B,CDC23,PSMD4,CDK1,PSMB3,UBC,CDC27,PSMD13,RPS27A,PSMD8,PSMD3,MAD2L1,PSMB2,PSME3,PSMD6,PSMC5,UBE2C,PSMC1
R-HSA-69190	DNA strand elongation	9.74643080906525e-08	-16.143779596828	33	24	0.0105448154657293	2276	8202	9837,23649,5984,4175,5983,5422,3978,4171,10714,5982,4176,5424,84296,8318,6118,4173,5111,4174,84515,5981,57804,4172,2237,5425	GINS1,POLA2,RFC4,MCM6,RFC3,POLA1,LIG1,MCM2,POLD3,RFC2,MCM7,POLD1,GINS4,CDC45,RPA2,MCM4,PCNA,MCM5,MCM8,RFC1,POLD4,MCM3,FEN1,POLD2
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	1.0585397935541e-07	-16.0612052457839	64	38	0.0166959578207381	2276	8202	51433,5689,5693,9232,5713,5715,9491,5707,5687,5696,10393,5717,51434,7314,5686,5694,7311,5692,5702,991,5695,5682,29882,8697,5710,5691,7316,996,5719,6233,5709,5714,5690,5705,10197,9861,11065,5700	ANAPC5,PSMB1,PSMB5,PTTG1,PSMD7,PSMD9,PSMF1,PSMD1,PSMA6,PSMB8,ANAPC10,PSMD11,ANAPC7,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,PSMA1,ANAPC2,CDC23,PSMD4,PSMB3,UBC,CDC27,PSMD13,RPS27A,PSMD3,PSMD8,PSMB2,PSMC5,PSME3,PSMD6,UBE2C,PSMC1
R-HSA-195253	Degradation of beta-catenin by the destruction complex	1.15983187223957e-07	-15.969820594069	81	45	0.0197715289982425	2276	8202	5689,5693,5713,324,1488,5526,1452,5715,9491,5707,5687,5696,1499,5518,5717,7314,5686,5694,7091,7311,5692,7090,5702,5695,5682,23401,5710,5691,6934,7316,5529,5719,6233,5714,10023,5709,5690,2932,5527,10197,9861,5705,5700,5528,8945	PSMB1,PSMB5,PSMD7,APC,CTBP2,PPP2R5B,CSNK1A1,PSMD9,PSMF1,PSMD1,PSMA6,PSMB8,CTNNB1,PPP2R1A,PSMD11,UBB,PSMA5,PSMB6,TLE4,UBA52,PSMB4,TLE3,PSMC3,PSMB7,PSMA1,FRAT2,PSMD4,PSMB3,TCF7L2,UBC,PPP2R5E,PSMD13,RPS27A,PSMD8,FRAT1,PSMD3,PSMB2,GSK3B,PPP2R5C,PSME3,PSMD6,PSMC5,PSMC1,PPP2R5D,BTRC
R-HSA-2871837	FCERI mediated NF-kB activation	1.81476191447729e-07	-15.5221413684424	77	43	0.0188927943760984	2276	8202	23291,5689,5693,257397,5713,1147,5715,9491,5707,5687,5696,3551,5717,6885,7314,5970,5686,5694,5170,7311,5692,5702,5695,10892,5682,7335,5710,5691,7316,8517,5719,6233,5709,5714,7322,5690,5705,9861,10197,10454,5700,7334,8945	FBXW11,PSMB1,PSMB5,TAB3,PSMD7,CHUK,PSMD9,PSMF1,PSMD1,PSMA6,PSMB8,IKBKB,PSMD11,MAP3K7,UBB,RELA,PSMA5,PSMB6,PDPK1,UBA52,PSMB4,PSMC3,PSMB7,MALT1,PSMA1,UBE2V1,PSMD4,PSMB3,UBC,IKBKG,PSMD13,RPS27A,PSMD3,PSMD8,UBE2D2,PSMB2,PSMC5,PSMD6,PSME3,TAB1,PSMC1,UBE2N,BTRC
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	2.83029863666685e-07	-15.0777134195466	54	33	0.0144991212653779	2276	8202	5689,5693,7311,5692,991,5702,5695,5713,5682,5710,5715,9491,5691,7316,26271,5707,5687,5696,5719,6233,5714,5709,51343,5690,5717,9861,7314,10197,5705,5700,5686,8945,5694	PSMB1,PSMB5,UBA52,PSMB4,CDC20,PSMC3,PSMB7,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,FBXO5,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,FZR1,PSMB2,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,BTRC,PSMB6
R-HSA-380287	Centrosome maturation	2.8326612402156e-07	-15.0768790136044	73	41	0.0180140597539543	2276	8202	11258,22995,1781,10142,80321,10383,8655,10540,7531,984,5566,10844,9702,22897,1069,9738,80184,5518,55835,84131,85378,10733,3320,10426,1639,1454,55755,121441,79959,22994,983,7532,4926,5108,11190,4957,10806,8481,8636,55125,203068	DCTN3,CEP152,DYNC1I2,AKAP9,CEP70,TUBB4B,DYNLL1,DCTN2,YWHAE,CDK11B,PRKACA,TUBGCP2,CEP57,CEP164,CETN2,CCP110,CEP290,PPP2R1A,CENPJ,CEP78,TUBGCP6,PLK4,HSP90AA1,TUBGCP3,DCTN1,CSNK1E,CDK5RAP2,NEDD1,CEP76,CEP131,CDK1,YWHAG,NUMA1,PCM1,CEP250,ODF2,SDCCAG8,OFD1,SSNA1,CEP192,TUBB
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	2.8326612402156e-07	-15.0768790136044	73	41	0.0180140597539543	2276	8202	11258,22995,1781,10142,80321,10383,8655,10540,7531,984,5566,10844,9702,22897,1069,9738,80184,5518,55835,84131,85378,10733,3320,10426,1639,1454,55755,121441,79959,22994,983,7532,4926,5108,11190,4957,10806,8481,8636,55125,203068	DCTN3,CEP152,DYNC1I2,AKAP9,CEP70,TUBB4B,DYNLL1,DCTN2,YWHAE,CDK11B,PRKACA,TUBGCP2,CEP57,CEP164,CETN2,CCP110,CEP290,PPP2R1A,CENPJ,CEP78,TUBGCP6,PLK4,HSP90AA1,TUBGCP3,DCTN1,CSNK1E,CDK5RAP2,NEDD1,CEP76,CEP131,CDK1,YWHAG,NUMA1,PCM1,CEP250,ODF2,SDCCAG8,OFD1,SSNA1,CEP192,TUBB
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	3.02127230810611e-07	-15.0124176142161	83	45	0.0197715289982425	2276	8202	2071,54617,3978,7329,5424,7341,5886,6118,1069,5111,51138,2968,8533,5887,54778,2965,79913,2068,125476,7314,57804,2067,1643,5984,7311,5983,902,9318,10038,10714,5982,7515,7316,50813,8607,7336,6233,10987,29844,2073,5981,7334,86,1642,5425	ERCC3,INO80,LIG1,UBE2I,POLD1,SUMO1,RAD23A,RPA2,CETN2,PCNA,COPS4,GTF2H4,COPS3,RAD23B,RNF111,GTF2H1,ACTR5,ERCC2,INO80C,UBB,POLD4,ERCC1,DDB2,RFC4,UBA52,RFC3,CCNH,COPS2,PARP2,POLD3,RFC2,XRCC1,UBC,COPS7A,RUVBL1,UBE2V2,RPS27A,COPS5,TFPT,ERCC5,RFC1,UBE2N,ACTL6A,DDB1,POLD2
R-HSA-1169091	Activation of NF-kappaB in B cells	3.23831713417838e-07	-14.9430418591219	66	38	0.0166959578207381	2276	8202	23291,5689,5693,5966,5713,1147,5715,9491,5687,5696,5707,3551,5717,6885,7314,5970,5686,5694,7311,5692,5702,5695,10892,5682,5710,7316,5691,8517,5719,6233,5709,5714,5690,5705,9861,10197,5700,8945	FBXW11,PSMB1,PSMB5,REL,PSMD7,CHUK,PSMD9,PSMF1,PSMA6,PSMB8,PSMD1,IKBKB,PSMD11,MAP3K7,UBB,RELA,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,MALT1,PSMA1,PSMD4,UBC,PSMB3,IKBKG,PSMD13,RPS27A,PSMD3,PSMD8,PSMB2,PSMC5,PSMD6,PSME3,PSMC1,BTRC
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	3.23831713417838e-07	-14.9430418591219	66	38	0.0166959578207381	2276	8202	5689,5693,5713,5715,9491,7465,5707,5687,890,5696,4609,51343,1163,1027,5717,7314,5686,5694,993,7311,902,5692,5702,6502,5695,5682,5710,5691,7316,5719,6233,5709,5714,5690,10197,9861,5705,5700	PSMB1,PSMB5,PSMD7,PSMD9,PSMF1,WEE1,PSMD1,PSMA6,CCNA2,PSMB8,MYC,FZR1,CKS1B,CDKN1B,PSMD11,UBB,PSMA5,PSMB6,CDC25A,UBA52,CCNH,PSMB4,PSMC3,SKP2,PSMB7,PSMA1,PSMD4,PSMB3,UBC,PSMD13,RPS27A,PSMD3,PSMD8,PSMB2,PSME3,PSMD6,PSMC5,PSMC1
R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	3.41517300060196e-07	-14.8898675001844	52	32	0.0140597539543058	2276	8202	993,5689,5693,7311,5692,5702,5695,5713,5682,1111,5710,5715,9491,5691,7316,5687,5696,5707,5719,6233,5714,5709,5690,5717,11200,9861,7314,10197,5705,5700,5686,5694	CDC25A,PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,CHEK1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,PSMA6,PSMB8,PSMD1,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,CHEK2,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,PSMB6
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	3.41517300060196e-07	-14.8898675001844	52	32	0.0140597539543058	2276	8202	993,5689,5693,7311,5692,5702,5695,5713,5682,1111,5710,5715,9491,5691,7316,5687,5696,5707,5719,6233,5714,5709,5690,5717,11200,9861,7314,10197,5705,5700,5686,5694	CDC25A,PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,CHEK1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,PSMA6,PSMB8,PSMD1,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,CHEK2,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,PSMB6
R-HSA-69610	p53-Independent DNA Damage Response	3.41517300060196e-07	-14.8898675001844	52	32	0.0140597539543058	2276	8202	993,5689,5693,7311,5692,5702,5695,5713,5682,1111,5710,5715,9491,5691,7316,5687,5696,5707,5719,6233,5714,5709,5690,5717,11200,9861,7314,10197,5705,5700,5686,5694	CDC25A,PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,CHEK1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,PSMA6,PSMB8,PSMD1,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,CHEK2,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,PSMB6
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	3.47660394449983e-07	-14.8720397116682	59	35	0.015377855887522	2276	8202	23291,5689,5693,5713,1147,5715,9491,5687,5696,5707,5971,5717,7314,4791,5970,5686,5694,7311,5692,5702,5695,5682,5710,7316,5691,5719,6233,5709,5714,5690,9861,10197,5705,5700,8945	FBXW11,PSMB1,PSMB5,PSMD7,CHUK,PSMD9,PSMF1,PSMA6,PSMB8,PSMD1,RELB,PSMD11,UBB,NFKB2,RELA,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,PSMD4,UBC,PSMB3,PSMD13,RPS27A,PSMD3,PSMD8,PSMB2,PSMD6,PSME3,PSMC5,PSMC1,BTRC
R-HSA-381119	Unfolded Protein Response (UPR)	3.78722672496323e-07	-14.7864616345508	86	46	0.0202108963093146	2276	8202	9820,7184,7094,64061,23480,7095,9451,5526,4189,4000,811,1200,440,23016,6464,11340,54512,55033,9114,10113,1639,7709,23404,118460,468,6734,2931,3309,10525,5393,467,84447,27230,9709,167227,22872,10897,55062,7466,7494,4802,8570,439,22926,1649,116138	CUL7,HSP90B1,TLN1,TSPYL2,SEC61G,SEC62,EIF2AK3,PPP2R5B,DNAJB9,LMNA,CALR,TPP1,ASNS,EXOSC7,SHC1,EXOSC8,EXOSC4,FKBP14,ATP6V0D1,PREB,DCTN1,ZBTB17,EXOSC2,EXOSC6,ATF4,SRPR,GSK3A,HSPA5,HYOU1,EXOSC9,ATF3,SYVN1,SERP1,HERPUD1,DCP2,SEC31A,YIF1A,WIPI1,WFS1,XBP1,NFYC,KHSRP,ASNA1,ATF6,DDIT3,KLHDC3
R-HSA-1236974	ER-Phagosome pathway	4.01154546134951e-07	-14.7289190820553	64	37	0.0162565905096661	2276	8202	5689,5693,23480,3133,3134,6890,5713,567,5715,9491,3105,811,5707,5687,5696,5717,3107,7314,5686,5694,7311,5692,5702,5695,5682,5710,5691,7316,5719,6233,5709,5714,5690,5705,9861,10197,5700	PSMB1,PSMB5,SEC61G,HLA-E,HLA-F,TAP1,PSMD7,B2M,PSMD9,PSMF1,HLA-A,CALR,PSMD1,PSMA6,PSMB8,PSMD11,HLA-C,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,PSMD4,PSMB3,UBC,PSMD13,RPS27A,PSMD3,PSMD8,PSMB2,PSMC5,PSMD6,PSME3,PSMC1
R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1	4.10530232120059e-07	-14.705816263701	50	31	0.0136203866432337	2276	8202	5689,5693,7311,5692,1019,5702,5695,5713,5682,5710,5715,9491,5691,7316,595,5707,5687,5696,5719,6233,5714,5709,5690,5717,9861,7314,10197,5705,5700,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,CDK4,PSMC3,PSMB7,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,CCND1,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,PSMB6
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	4.10530232120059e-07	-14.705816263701	50	31	0.0136203866432337	2276	8202	5689,5693,7311,5692,1019,5702,5695,5713,5682,5710,5715,9491,5691,7316,595,5707,5687,5696,5719,6233,5714,5709,5690,5717,9861,7314,10197,5705,5700,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,CDK4,PSMC3,PSMB7,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,CCND1,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,PSMB6
R-HSA-72306	tRNA processing	4.48498573877627e-07	-14.6173603352126	94	49	0.0215289982425308	2276	8202	348180,23511,8480,55621,10978,53371,10775,51367,79074,23165,129401,127253,4927,54482,55746,10248,9836,9972,93587,55039,79691,4234,51095,60487,54888,55253,113179,60528,55644,9631,51504,51637,8021,11260,5903,2058,11102,339487,51002,129450,10785,23536,54901,1478,23636,283742,90353,9818,8086	CTU2,NUP188,RAE1,TRMT1,CLP1,NUP54,POP4,POP5,C2orf49,NUP205,NUP35,TYW3,NUP88,TRMT13,NUP133,POP7,LCMT2,NUP153,TRMT10A,TRMT12,QTRTD1,METTL1,TRNT1,TRMT11,NSUN2,TYW1,ADAT3,ELAC2,OSGEP,NUP155,TRMT112,C14orf166,NUP214,XPOT,RANBP2,EPRS,RPP14,ZBTB8OS,TPRKB,TYW5,WDR4,ADAT1,CDKAL1,CSTF2,NUP62,FAM98B,CTU1,NUP58,AAAS
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	5.20088469481662e-07	-14.4692669062234	55	33	0.0144991212653779	2276	8202	5689,5693,7311,5692,5702,3312,5695,5713,5682,5710,5715,9491,5691,7316,3304,5707,5687,5696,5719,6233,5714,5709,5690,3184,5717,5705,9861,7314,10197,5700,26986,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,HSPA8,PSMB7,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,HSPA1B,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,HNRNPD,PSMD11,PSMC5,PSMD6,UBB,PSME3,PSMC1,PABPC1,PSMA5,PSMB6
R-HSA-446203	Asparagine N-linked glycosylation	5.67793691977659e-07	-14.3815077025542	181	81	0.0355887521968366	2276	8202	4351,5589,26984,1798,821,9919,9117,6484,5537,4124,51399,6185,10342,23193,144245,10802,10484,8615,23256,4597,26503,90411,5861,91869,29926,5372,10195,79947,1650,3703,10972,57171,4253,6400,440138,29925,6483,8704,6396,9871,10905,79087,6480,10825,10020,79053,56886,5373,966,811,6184,9632,79868,1603,81876,10960,10559,22870,10959,6811,10113,9761,11253,375056,80267,1294,10282,84447,4758,22872,51128,27095,11196,6675,84061,2801,199857,9554,85365,55291,79090	MPI,PRKCSH,SEC22A,DPAGT1,CANX,SEC16A,SEC22C,ST3GAL4,PPP6C,MAN2A1,TRAPPC4,RPN2,TFG,GANAB,ALG10B,SEC24A,SEC23A,USO1,SCFD1,MVD,SLC17A5,MCFD2,RAB1A,RFT1,GMPPA,PMM1,ALG3,DHDDS,DDOST,STT3A,TMED10,DOLPP1,CTAGE5,SEL1L,ALG11,GMPPB,ST3GAL2,B4GALT2,SEC13,SEC24D,MAN1A2,ALG12,ST6GAL1,NEU3,GNE,ALG8,UGGT1,PMM2,CD59,CALR,RPN1,SEC24C,ALG13,DAD1,RAB1B,LMAN2,SLC35A1,PPP6R1,TMED2,STX5,PREB,MLEC,MAN1B1,MIA3,EDEM3,COL7A1,BET1,SYVN1,NEU1,SEC31A,SAR1B,TRAPPC3,SEC23IP,UAP1,MAGT1,GOLGA2,ALG14,SEC22B,ALG2,PPP6R3,TRAPPC6A
R-HSA-69202	Cyclin E associated events during G1/S transition	6.84012687864099e-07	-14.195289369987	65	37	0.0162565905096661	2276	8202	5689,5693,5713,5715,9491,7465,5707,5687,890,5696,4609,1163,1027,5717,7314,5686,5694,993,7311,902,5692,5702,6502,5695,5682,5710,5691,7316,5719,6233,5709,5714,5690,10197,9861,5705,5700	PSMB1,PSMB5,PSMD7,PSMD9,PSMF1,WEE1,PSMD1,PSMA6,CCNA2,PSMB8,MYC,CKS1B,CDKN1B,PSMD11,UBB,PSMA5,PSMB6,CDC25A,UBA52,CCNH,PSMB4,PSMC3,SKP2,PSMB7,PSMA1,PSMD4,PSMB3,UBC,PSMD13,RPS27A,PSMD3,PSMD8,PSMB2,PSME3,PSMD6,PSMC5,PSMC1
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	7.56124588298219e-07	-14.0950596750085	58	34	0.0149384885764499	2276	8202	23291,5689,5693,5713,1147,5715,9491,5687,5696,5707,5971,5717,7314,4791,5686,5694,7311,5692,5702,5695,5682,5710,7316,5691,5719,6233,5709,5714,5690,9861,10197,5705,5700,8945	FBXW11,PSMB1,PSMB5,PSMD7,CHUK,PSMD9,PSMF1,PSMA6,PSMB8,PSMD1,RELB,PSMD11,UBB,NFKB2,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,PSMD4,UBC,PSMB3,PSMD13,RPS27A,PSMD3,PSMD8,PSMB2,PSMD6,PSME3,PSMC5,PSMC1,BTRC
R-HSA-380259	Loss of Nlp from mitotic centrosomes	8.50744303435719e-07	-13.97715421952	63	36	0.015817223198594	2276	8202	11258,22995,1781,10142,80321,10383,8655,10540,7531,5566,9702,22897,1069,9738,80184,5518,55835,84131,10733,3320,1639,1454,55755,121441,79959,22994,983,7532,5108,11190,4957,10806,8481,8636,55125,203068	DCTN3,CEP152,DYNC1I2,AKAP9,CEP70,TUBB4B,DYNLL1,DCTN2,YWHAE,PRKACA,CEP57,CEP164,CETN2,CCP110,CEP290,PPP2R1A,CENPJ,CEP78,PLK4,HSP90AA1,DCTN1,CSNK1E,CDK5RAP2,NEDD1,CEP76,CEP131,CDK1,YWHAG,PCM1,CEP250,ODF2,SDCCAG8,OFD1,SSNA1,CEP192,TUBB
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	8.50744303435719e-07	-13.97715421952	63	36	0.015817223198594	2276	8202	5440,57461,2071,56949,3978,5424,6118,5111,2968,57654,2965,6917,9716,2068,7314,57804,5431,27339,5984,3150,7311,5983,902,10714,5982,5430,7316,7515,5432,6233,2074,5434,5981,91603,1642,5425	POLR2K,ISY1,ERCC3,XAB2,LIG1,POLD1,RPA2,PCNA,GTF2H4,UVSSA,GTF2H1,TCEA1,AQR,ERCC2,UBB,POLD4,POLR2B,PRPF19,RFC4,HMGN1,UBA52,RFC3,CCNH,POLD3,RFC2,POLR2A,UBC,XRCC1,POLR2C,RPS27A,ERCC6,POLR2E,RFC1,ZNF830,DDB1,POLD2
R-HSA-380284	Loss of proteins required for interphase microtubule organizationfrom the centrosome	8.50744303435719e-07	-13.97715421952	63	36	0.015817223198594	2276	8202	11258,22995,1781,10142,80321,10383,8655,10540,7531,5566,9702,22897,1069,9738,80184,5518,55835,84131,10733,3320,1639,1454,55755,121441,79959,22994,983,7532,5108,11190,4957,10806,8481,8636,55125,203068	DCTN3,CEP152,DYNC1I2,AKAP9,CEP70,TUBB4B,DYNLL1,DCTN2,YWHAE,PRKACA,CEP57,CEP164,CETN2,CCP110,CEP290,PPP2R1A,CENPJ,CEP78,PLK4,HSP90AA1,DCTN1,CSNK1E,CDK5RAP2,NEDD1,CEP76,CEP131,CDK1,YWHAG,PCM1,CEP250,ODF2,SDCCAG8,OFD1,SSNA1,CEP192,TUBB
R-HSA-5687128	MAPK6/MAPK4 signaling	9.06250124274142e-07	-13.9139504936474	88	46	0.0202108963093146	2276	8202	23112,5689,5693,5713,3337,5566,5715,9491,3725,5707,5687,5696,998,8555,4609,5717,7314,5686,5694,5058,7311,5692,5702,8550,5695,5682,989,5710,983,5691,7316,8202,7514,5719,6233,5714,5709,5597,5690,9861,10197,5705,4343,8556,5700,192669	TNRC6B,PSMB1,PSMB5,PSMD7,DNAJB1,PRKACA,PSMD9,PSMF1,JUN,PSMD1,PSMA6,PSMB8,CDC42,CDC14B,MYC,PSMD11,UBB,PSMA5,PSMB6,PAK1,UBA52,PSMB4,PSMC3,MAPKAPK5,PSMB7,PSMA1,SEPT7,PSMD4,CDK1,PSMB3,UBC,NCOA3,XPO1,PSMD13,RPS27A,PSMD8,PSMD3,MAPK6,PSMB2,PSMD6,PSME3,PSMC5,MOV10,CDC14A,PSMC1,AGO3
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	9.30896771709485e-07	-13.887117444754	56	33	0.0144991212653779	2276	8202	5689,5693,7311,5692,5702,5695,6502,5713,5682,5710,5715,9491,5691,7316,5707,5687,890,5696,5719,6233,5714,5709,1163,5690,1027,5717,5705,9861,7314,10197,5700,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,SKP2,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,PSMD1,PSMA6,CCNA2,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,CKS1B,PSMB2,CDKN1B,PSMD11,PSMC5,PSMD6,UBB,PSME3,PSMC1,PSMA5,PSMB6
R-HSA-504046	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	1.33794988647632e-06	-13.5243720510132	145	67	0.0294376098418278	2276	8202	3015,2071,25885,8350,51728,8365,54700,2968,8364,55703,3017,8331,902,723790,85236,4774,5451,3021,8340,6618,53615,7343,8362,2074,55290,3014,6619,2972,128312,3066,6617,7978,64216,6908,8367,5440,171568,7702,8347,7270,8360,54815,661,284119,2965,653604,2068,9330,64425,10302,10621,57459,5931,9328,9219,55814,8363,8368,4781,11128,221830,11335,3012,51082,9329,5434,4782	H2AFZ,ERCC3,POLR1A,HIST1H3A,POLR3K,HIST1H4H,RRN3,GTF2H4,HIST1H4C,POLR3B,HIST1H2BD,HIST1H2AJ,CCNH,HIST2H2AA4,HIST1H2BK,NFIA,POU2F1,H3F3B,HIST1H2BL,SNAPC2,MBD3,UBTF,HIST1H4K,ERCC6,BRF2,H2AFX,SNAPC3,BRF1,HIST3H2BB,HDAC2,SNAPC1,MTERF1,TFB2M,TBP,HIST1H4E,POLR2K,POLR3H,ZNF143,HIST1H2BC,TTF1,HIST1H4D,GATAD2A,POLR3D,PTRF,GTF2H1,HIST2H3D,ERCC2,GTF3C3,POLR1E,SNAPC5,POLR3F,GATAD2B,RBBP7,GTF3C5,MTA2,BDP1,HIST1H4J,HIST1H4L,NFIB,POLR3A,TWISTNB,CBX3,HIST1H2AE,POLR1D,GTF3C4,POLR2E,NFIC
R-HSA-6782135	Dual incision in TC-NER	1.42878827711194e-06	-13.4586838315667	64	36	0.015817223198594	2276	8202	5440,57461,2071,56949,5424,6118,5111,2968,57654,2965,6917,2068,9716,7314,57804,5431,27339,2067,5984,3150,7311,5983,902,10714,5982,5430,7316,5432,6233,2074,5434,2073,5981,91603,1642,5425	POLR2K,ISY1,ERCC3,XAB2,POLD1,RPA2,PCNA,GTF2H4,UVSSA,GTF2H1,TCEA1,ERCC2,AQR,UBB,POLD4,POLR2B,PRPF19,ERCC1,RFC4,HMGN1,UBA52,RFC3,CCNH,POLD3,RFC2,POLR2A,UBC,POLR2C,RPS27A,ERCC6,POLR2E,ERCC5,RFC1,ZNF830,DDB1,POLD2
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	1.71487362026812e-06	-13.2761711708674	50	30	0.0131810193321617	2276	8202	5689,5693,7311,5692,5702,5695,5713,5682,990,5710,5715,9491,5691,7316,5707,5687,5696,5719,6233,5714,5709,5690,5717,9861,7314,10197,5705,5700,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,CDC6,PSMD4,PSMD9,PSMF1,PSMB3,UBC,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,PSMB6
R-HSA-5387390	Hh mutants abrogate ligand secretion	2.01155693572693e-06	-13.1166015408481	55	32	0.0140597539543058	2276	8202	5689,5693,7311,5692,5702,5695,5713,5682,84447,5710,5715,9491,5691,7415,7316,5696,5687,5707,5719,6233,5714,5709,6400,5690,5717,9861,5705,7314,10197,5700,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,SYVN1,PSMD4,PSMD9,PSMF1,PSMB3,VCP,UBC,PSMB8,PSMA6,PSMD1,PSMD13,RPS27A,PSMD8,PSMD3,SEL1L,PSMB2,PSMD11,PSMD6,PSMC5,UBB,PSME3,PSMC1,PSMA5,PSMB6
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	2.01155693572693e-06	-13.1166015408481	55	32	0.0140597539543058	2276	8202	5689,5693,7311,5692,5702,5695,5713,5682,84447,5710,5715,9491,5691,7415,7316,5696,5687,5707,5719,6233,5714,5709,6400,5690,5717,9861,5705,7314,10197,5700,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,SYVN1,PSMD4,PSMD9,PSMF1,PSMB3,VCP,UBC,PSMB8,PSMA6,PSMD1,PSMD13,RPS27A,PSMD8,PSMD3,SEL1L,PSMB2,PSMD11,PSMD6,PSMC5,UBB,PSME3,PSMC1,PSMA5,PSMB6
R-HSA-195258	RHO GTPase Effectors	2.01675406502105e-06	-13.1140212375017	285	115	0.0505272407732865	2276	8202	10163,3015,4771,8936,10096,4627,8350,5526,11004,7531,81624,4628,23028,79003,8365,805,9183,55845,1499,998,5518,55746,9928,8364,8379,4637,1027,30851,2017,10097,147179,3017,10006,1856,8331,1058,348235,723790,4690,57120,991,85236,1742,10971,701,3021,6232,9212,8340,995,7532,79682,3796,5903,5529,8362,7514,79980,25936,8976,4085,3688,3014,5500,5527,6722,23122,128312,151648,5528,6396,4659,8367,11113,1495,1063,57591,55143,3831,55055,8347,8360,91687,79172,6242,5586,151246,9055,653604,9735,79019,114793,9475,10726,5170,5058,10152,23433,11130,8363,8368,10552,1729,401541,3012,332,4660,147841,7534,286205,1062,10109,57082,7533,23081	WASF2,H2AFZ,NF2,WASF1,ACTR3,MYH9,HIST1H3A,PPP2R5B,KIF2C,YWHAE,DIAPH3,MYH10,KDM1A,MIS12,HIST1H4H,CALM2,ZW10,BRK1,CTNNB1,CDC42,PPP2R1A,NUP133,KIF14,HIST1H4C,MAD1L1,MYL6,CDKN1B,TAX1BP3,CTTN,ACTR2,WIPF2,HIST1H2BD,ABI1,DVL2,HIST1H2AJ,CENPA,SKA2,HIST2H2AA4,NCK1,GOPC,CDC20,HIST1H2BK,DLG4,YWHAQ,BUB1B,H3F3B,RPS27,AURKB,HIST1H2BL,CDC25C,YWHAG,CENPU,KIF2A,RANBP2,PPP2R5E,HIST1H4K,XPO1,DSN1,NSL1,WASL,MAD2L1,ITGB1,H2AFX,PPP1CB,PPP2R5C,SRF,CLASP2,HIST3H2BB,SGOL1,PPP2R5D,SEC13,PPP1R12A,HIST1H4E,CIT,CTNNA1,CENPF,MKL1,CDCA8,KLC1,ZWILCH,HIST1H2BC,HIST1H4D,CENPL,CENPO,RTKN,PKN2,SGOL2,PRC1,HIST2H3D,KNTC1,CENPM,FMNL2,ROCK2,NUDC,PDPK1,PAK1,ABI2,RHOQ,ZWINT,HIST1H4J,HIST1H4L,ARPC1A,DIAPH1,CENPP,HIST1H2AE,BIRC5,PPP1R12B,SPC24,YWHAZ,SCAI,CENPE,ARPC2,CASC5,YWHAH,KDM4C
R-HSA-69615	G1/S DNA Damage Checkpoints	2.22514471002598e-06	-13.015688606247	60	34	0.0149384885764499	2276	8202	5689,5693,7157,5713,1111,5715,9491,5707,5687,5696,1027,5717,7314,5686,5694,993,7311,5692,5702,5695,5682,5710,7316,5691,5719,6233,5709,5714,5690,11200,5705,10197,9861,5700	PSMB1,PSMB5,TP53,PSMD7,CHEK1,PSMD9,PSMF1,PSMD1,PSMA6,PSMB8,CDKN1B,PSMD11,UBB,PSMA5,PSMB6,CDC25A,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,PSMD4,UBC,PSMB3,PSMD13,RPS27A,PSMD3,PSMD8,PSMB2,CHEK2,PSMC5,PSME3,PSMD6,PSMC1
R-HSA-180534	Vpu mediated degradation of CD4	3.06484068359174e-06	-12.6955149691794	51	30	0.0131810193321617	2276	8202	5689,5693,7311,5692,5702,5695,5713,5682,5710,5715,9491,5691,7316,5696,5687,5707,5719,6233,5714,5709,5690,5717,9861,5705,7314,10197,5700,8945,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,PSMB8,PSMA6,PSMD1,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,PSMD6,PSMC5,UBB,PSME3,PSMC1,BTRC,PSMA5,PSMB6
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	3.06484068359174e-06	-12.6955149691794	51	30	0.0131810193321617	2276	8202	5689,5693,7311,5692,5702,7157,5695,5713,5682,5710,5715,9491,5691,7316,5707,5687,5696,5719,6233,5714,5709,5690,5717,9861,7314,10197,5705,5700,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,TP53,PSMB7,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,PSMB6
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	3.77187016235589e-06	-12.4879396152182	49	29	0.0127416520210896	2276	8202	5689,5693,7311,5692,5702,5695,5713,5682,5710,5715,9491,5691,7316,5687,5696,5707,5719,6233,5714,5709,5690,5717,9861,7314,10197,5705,5700,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,PSMA6,PSMB8,PSMD1,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,PSMB6
R-HSA-3214847	HATs acetylate histones	3.85082854471117e-06	-12.4672222263997	143	65	0.0285588752196837	2276	8202	8350,85235,9643,440689,8365,8329,79595,8364,1386,3017,6871,8331,3054,84148,6881,7862,723790,26009,56943,11143,51147,85236,23326,8340,51230,79960,8362,55250,8607,8473,9575,128312,86,8367,9913,8518,11091,8969,317772,8347,8360,10933,10474,23587,6944,653604,54934,8520,8332,8336,5931,55167,54556,8363,8368,55683,23338,8330,8464,51562,3012,23522,10943,6883,112869	HIST1H3A,HIST1H2AH,MORF4L2,HIST2H2BF,HIST1H4H,HIST1H2AI,SAP130,HIST1H4C,ATF2,HIST1H2BD,TADA2A,HIST1H2AJ,HCFC1,KAT8,TAF10,BRPF1,HIST2H2AA4,ZZZ3,ENY2,KAT7,ING4,HIST1H2BK,USP22,HIST1H2BL,PHF20,JADE1,HIST1H4K,ELP2,RUVBL1,OGT,CLOCK,HIST3H2BB,ACTL6A,HIST1H4E,SUPT7L,IKBKAP,WDR5,HIST1H2AG,HIST2H2AB,HIST1H2BC,HIST1H4D,MORF4L1,TADA3,ELP5,VPS72,HIST2H3D,KANSL2,HAT1,HIST1H2AL,HIST1H2AM,RBBP7,MSL2,ING3,HIST1H4J,HIST1H4L,KANSL3,JADE2,HIST1H2AK,SUPT3H,MBIP,HIST1H2AE,KAT6B,MSL3,TAF12,SGF29
R-HSA-5693538	Homology Directed Repair	4.22798036916984e-06	-12.3737861330206	135	62	0.0272407732864675	2276	8202	5883,8367,83990,29086,144715,1111,641,7329,5424,8347,8360,7341,8365,6118,5111,890,8364,7516,6047,84126,545,7314,57804,3017,2237,2067,5984,5983,5810,7311,11073,51548,10038,5531,85236,7156,5893,9025,5884,8340,8363,8368,10714,5982,7515,7316,9156,5889,8362,675,7336,7158,6233,3014,51720,7517,165918,5981,128312,348654,7334,5425	RAD9A,HIST1H4E,BRIP1,BABAM1,RAD9B,CHEK1,BLM,UBE2I,POLD1,HIST1H2BC,HIST1H4D,SUMO1,HIST1H4H,RPA2,PCNA,CCNA2,HIST1H4C,XRCC2,RNF4,ATRIP,ATR,UBB,POLD4,HIST1H2BD,FEN1,ERCC1,RFC4,RFC3,RAD1,UBA52,TOPBP1,SIRT6,PARP2,PPP4C,HIST1H2BK,TOP3A,RAD52,RNF8,RAD17,HIST1H2BL,HIST1H4J,HIST1H4L,POLD3,RFC2,XRCC1,UBC,EXO1,RAD51C,HIST1H4K,BRCA2,UBE2V2,TP53BP1,RPS27A,H2AFX,UIMC1,XRCC3,RNF168,RFC1,HIST3H2BB,GEN1,UBE2N,POLD2
R-HSA-4641257	Degradation of AXIN	4.29325304747204e-06	-12.358465826254	54	31	0.0136203866432337	2276	8202	5689,5693,7311,5692,5702,5695,5713,5682,5710,5715,9491,8658,5691,7316,5707,5687,5696,5719,6233,5714,5709,5690,5717,9861,7314,10197,5705,5700,81847,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,TNKS,PSMB3,UBC,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,RNF146,PSMA5,PSMB6
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	4.29325304747204e-06	-12.358465826254	54	31	0.0136203866432337	2276	8202	11338,23511,8480,6431,10250,9939,10921,53371,10482,7884,9631,6430,8021,23165,129401,6426,5903,4686,4927,10189,55746,7307,6429,23636,9972,6428,51692,1977,9818,8086,9785	U2AF2,NUP188,RAE1,SRSF6,SRRM1,RBM8A,RNPS1,NUP54,NXF1,SLBP,NUP155,SRSF5,NUP214,NUP205,NUP35,SRSF1,RANBP2,NCBP1,NUP88,ALYREF,NUP133,U2AF1,SRSF4,NUP62,NUP153,SRSF3,CPSF3,EIF4E,NUP58,AAAS,DHX38
R-HSA-199991	Membrane Trafficking	4.34202303470482e-06	-12.3471701814313	256	104	0.0456942003514939	2276	8202	51552,27243,5564,6517,5565,26984,25977,162,7531,9919,8027,8729,9117,2647,805,4218,57148,5537,51399,8907,1785,55770,10342,1315,10802,10484,8615,7311,23256,208,3312,9525,5571,10971,7163,90411,5861,25978,7532,10890,22818,10972,6233,1213,4253,7251,6814,2580,9847,27131,22820,6396,6272,9871,51534,4012,11267,7082,7164,9685,8766,7037,4641,9276,4074,966,9632,81876,10960,7314,22870,10959,10113,6811,2512,23433,54885,375056,1777,1294,10282,9179,6810,51652,26258,8301,7316,22872,51128,27095,51422,11196,2801,79720,60412,9554,7534,55291,7533,79090,9882,164,5878,23557	RAB14,CHMP2A,PRKAB1,SLC2A4,PRKAB2,SEC22A,NECAP1,AP1B1,YWHAE,SEC16A,STAM,GBF1,SEC22C,BLOC1S1,CALM2,RAB8A,RALGAPB,PPP6C,TRAPPC4,AP1M1,DNM2,EXOC2,TFG,COPB1,SEC24A,SEC23A,USO1,UBA52,SCFD1,AKT2,HSPA8,VPS4B,PRKAG1,YWHAQ,TPD52,MCFD2,RAB1A,CHMP2B,YWHAG,RAB10,COPZ1,TMED10,RPS27A,CLTC,CTAGE5,TSG101,STXBP3,GAK,C2CD5,SNX5,COPG1,SEC13,SORT1,SEC24D,VTA1,LNPEP,SNF8,TJP1,TPD52L1,CLINT1,RAB11A,TFRC,MYO1C,COPB2,M6PR,CD59,SEC24C,RAB1B,LMAN2,UBB,PPP6R1,TMED2,PREB,STX5,FTL,RHOQ,TBC1D8B,MIA3,DNASE2,COL7A1,BET1,AP4M1,STX4,CHMP3,BLOC1S6,PICALM,UBC,SEC31A,SAR1B,TRAPPC3,PRKAG2,SEC23IP,GOLGA2,VPS37B,EXOC4,SEC22B,YWHAZ,PPP6R3,YWHAH,TRAPPC6A,TBC1D4,AP1G1,RAB5C,SNAPIN
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	4.45820404399228e-06	-12.3207645537492	40	25	0.0109841827768014	2276	8202	5440,9328,6908,171568,55814,4774,5451,7702,6618,4781,51728,11128,661,51082,55290,5434,9329,4782,9330,2972,55703,6619,10302,6617,10621	POLR2K,GTF3C5,TBP,POLR3H,BDP1,NFIA,POU2F1,ZNF143,SNAPC2,NFIB,POLR3K,POLR3A,POLR3D,POLR1D,BRF2,POLR2E,GTF3C4,NFIC,GTF3C3,BRF1,POLR3B,SNAPC3,SNAPC5,SNAPC1,POLR3F
R-HSA-74158	RNA Polymerase III Transcription	4.45820404399228e-06	-12.3207645537492	40	25	0.0109841827768014	2276	8202	5440,9328,6908,171568,55814,4774,5451,7702,6618,4781,51728,11128,661,51082,55290,5434,9329,4782,9330,2972,55703,6619,10302,6617,10621	POLR2K,GTF3C5,TBP,POLR3H,BDP1,NFIA,POU2F1,ZNF143,SNAPC2,NFIB,POLR3K,POLR3A,POLR3D,POLR1D,BRF2,POLR2E,GTF3C4,NFIC,GTF3C3,BRF1,POLR3B,SNAPC3,SNAPC5,SNAPC1,POLR3F
R-HSA-162909	Host Interactions of HIV factors	4.57978190560273e-06	-12.293859179836	127	59	0.0259226713532513	2276	8202	5689,23511,5693,8480,53371,5713,4869,567,162,5715,9491,23165,3105,5478,129401,4927,5696,5687,5707,55746,8907,163,5717,9972,51606,7314,3837,5686,5694,7311,5692,5702,5695,5682,6921,9631,5710,8021,5691,7316,5903,7514,5719,6233,5714,160,5709,5690,23636,3159,9861,5705,10197,164,5700,1175,9818,8086,8945	PSMB1,NUP188,PSMB5,RAE1,NUP54,PSMD7,NPM1,B2M,AP1B1,PSMD9,PSMF1,NUP205,HLA-A,PPIA,NUP35,NUP88,PSMB8,PSMA6,PSMD1,NUP133,AP1M1,AP2B1,PSMD11,NUP153,ATP6V1H,UBB,KPNB1,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,TCEB1,NUP155,PSMD4,NUP214,PSMB3,UBC,RANBP2,XPO1,PSMD13,RPS27A,PSMD8,AP2A1,PSMD3,PSMB2,NUP62,HMGA1,PSMD6,PSMC5,PSME3,AP1G1,PSMC1,AP2S1,NUP58,AAAS,BTRC
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	4.62804351822721e-06	-12.28337634543	59	33	0.0144991212653779	2276	8202	5689,5693,7311,5692,5702,5695,5713,5682,5710,1452,5566,5715,9491,5691,7316,5707,5687,5696,5719,6233,5714,5709,5690,2932,5717,9861,7314,10197,5705,5700,5686,8945,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,PSMD4,CSNK1A1,PRKACA,PSMD9,PSMF1,PSMB3,UBC,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,GSK3B,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,BTRC,PSMB6
R-HSA-5610780	Degradation of GLI1 by the proteasome	4.62804351822721e-06	-12.28337634543	59	33	0.0144991212653779	2276	8202	5689,5693,7311,5692,5702,5695,5713,5682,5710,5566,5715,9491,5691,7316,5707,5687,5696,5719,6233,5714,5709,5690,5717,9861,7314,10197,5705,5700,5686,8650,8945,5694,2735	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,PSMD4,PRKACA,PSMD9,PSMF1,PSMB3,UBC,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,NUMB,BTRC,PSMB6,GLI1
R-HSA-5610783	Degradation of GLI2 by the proteasome	4.62804351822721e-06	-12.28337634543	59	33	0.0144991212653779	2276	8202	5689,5693,7311,5692,5702,5695,5713,5682,5710,1452,5566,5715,9491,5691,7316,5707,5687,5696,5719,6233,5714,5709,5690,2932,5717,9861,7314,10197,5705,5700,5686,8945,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,PSMD4,CSNK1A1,PRKACA,PSMD9,PSMF1,PSMB3,UBC,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,GSK3B,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,BTRC,PSMB6
R-HSA-69541	Stabilization of p53	5.33198766473486e-06	-12.1417864690911	52	30	0.0131810193321617	2276	8202	5689,5693,7311,5692,5702,7157,5695,5713,5682,5710,5715,9491,5691,7316,5707,5687,5696,5719,6233,5714,5709,5690,5717,9861,7314,10197,5705,5700,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,TP53,PSMB7,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,PSMB6
R-HSA-167172	Transcription of the HIV genome	6.04492056177533e-06	-12.0162922151294	67	36	0.015817223198594	2276	8202	9150,6884,6872,2071,5440,6908,2962,8178,2968,83860,2963,2965,2960,6917,2068,6882,2959,5431,6881,6877,902,8731,7936,6921,2958,6875,6829,7469,5430,11198,6873,5432,4686,5434,6883,6878	CTDP1,TAF13,TAF1,ERCC3,POLR2K,TBP,GTF2F1,ELL,GTF2H4,TAF3,GTF2F2,GTF2H1,GTF2E1,TCEA1,ERCC2,TAF11,GTF2B,POLR2B,TAF10,TAF5,CCNH,RNMT,NELFE,TCEB1,GTF2A2,TAF4B,SUPT5H,NELFA,POLR2A,SUPT16H,TAF2,POLR2C,NCBP1,POLR2E,TAF12,TAF6
R-HSA-4839726	Chromatin organization	6.57271297286826e-06	-11.9325838772358	261	105	0.0461335676625659	2276	8202	3015,7403,9682,8350,85235,9643,23028,440689,8365,8329,79595,595,8364,9070,4297,1386,3017,6871,5926,8331,8819,84148,3054,6595,6881,7862,26009,723790,56943,11143,51147,23133,1019,85236,79084,55193,23326,8340,53615,51230,25855,79960,8362,23030,55250,8607,3014,8473,10284,9575,128312,86,3066,84661,8367,3276,23210,11091,9913,8518,8969,5929,8347,317772,8360,10474,10933,54815,23587,387893,6944,653604,3717,54934,8332,10419,8520,57459,8336,55167,5931,5927,9219,84159,54556,23186,10362,8363,8368,23338,55818,55683,8464,8330,51562,3012,2874,23522,9757,10943,6907,6603,6883,112869,23081	H2AFZ,KDM6A,KDM4A,HIST1H3A,HIST1H2AH,MORF4L2,KDM1A,HIST2H2BF,HIST1H4H,HIST1H2AI,SAP130,CCND1,HIST1H4C,ASH2L,KMT2A,ATF2,HIST1H2BD,TADA2A,ARID4A,HIST1H2AJ,SAP30,KAT8,HCFC1,SMARCA2,TAF10,BRPF1,ZZZ3,HIST2H2AA4,ENY2,KAT7,ING4,PHF8,CDK4,HIST1H2BK,WDR77,PBRM1,USP22,HIST1H2BL,MBD3,PHF20,BRMS1,JADE1,HIST1H4K,KDM4B,ELP2,RUVBL1,H2AFX,OGT,SAP18,CLOCK,HIST3H2BB,ACTL6A,HDAC2,DPY30,HIST1H4E,PRMT1,JMJD6,WDR5,SUPT7L,IKBKAP,HIST1H2AG,RBBP5,HIST1H2BC,HIST2H2AB,HIST1H4D,TADA3,MORF4L1,GATAD2A,ELP5,KMT5A,VPS72,HIST2H3D,JAK2,KANSL2,HIST1H2AL,PRMT5,HAT1,GATAD2B,HIST1H2AM,MSL2,RBBP7,KDM5A,MTA2,ARID5B,ING3,RCOR1,HMG20B,HIST1H4J,HIST1H4L,JADE2,KDM3A,KANSL3,SUPT3H,HIST1H2AK,MBIP,HIST1H2AE,GPS2,KAT6B,KMT2B,MSL3,TBL1X,SMARCD2,TAF12,SGF29,KDM4C
R-HSA-3247509	Chromatin modifying enzymes	6.57271297286826e-06	-11.9325838772358	261	105	0.0461335676625659	2276	8202	3015,7403,9682,8350,85235,9643,23028,440689,8365,8329,79595,595,8364,9070,4297,1386,3017,6871,5926,8331,8819,84148,3054,6595,6881,7862,26009,723790,56943,11143,51147,23133,1019,85236,79084,55193,23326,8340,53615,51230,25855,79960,8362,23030,55250,8607,3014,8473,10284,9575,128312,86,3066,84661,8367,3276,23210,11091,9913,8518,8969,5929,8347,317772,8360,10474,10933,54815,23587,387893,6944,653604,3717,54934,8332,10419,8520,57459,8336,55167,5931,5927,9219,84159,54556,23186,10362,8363,8368,23338,55818,55683,8464,8330,51562,3012,2874,23522,9757,10943,6907,6603,6883,112869,23081	H2AFZ,KDM6A,KDM4A,HIST1H3A,HIST1H2AH,MORF4L2,KDM1A,HIST2H2BF,HIST1H4H,HIST1H2AI,SAP130,CCND1,HIST1H4C,ASH2L,KMT2A,ATF2,HIST1H2BD,TADA2A,ARID4A,HIST1H2AJ,SAP30,KAT8,HCFC1,SMARCA2,TAF10,BRPF1,ZZZ3,HIST2H2AA4,ENY2,KAT7,ING4,PHF8,CDK4,HIST1H2BK,WDR77,PBRM1,USP22,HIST1H2BL,MBD3,PHF20,BRMS1,JADE1,HIST1H4K,KDM4B,ELP2,RUVBL1,H2AFX,OGT,SAP18,CLOCK,HIST3H2BB,ACTL6A,HDAC2,DPY30,HIST1H4E,PRMT1,JMJD6,WDR5,SUPT7L,IKBKAP,HIST1H2AG,RBBP5,HIST1H2BC,HIST2H2AB,HIST1H4D,TADA3,MORF4L1,GATAD2A,ELP5,KMT5A,VPS72,HIST2H3D,JAK2,KANSL2,HIST1H2AL,PRMT5,HAT1,GATAD2B,HIST1H2AM,MSL2,RBBP7,KDM5A,MTA2,ARID5B,ING3,RCOR1,HMG20B,HIST1H4J,HIST1H4L,JADE2,KDM3A,KANSL3,SUPT3H,HIST1H2AK,MBIP,HIST1H2AE,GPS2,KAT6B,KMT2B,MSL3,TBL1X,SMARCD2,TAF12,SGF29,KDM4C
R-HSA-169911	Regulation of Apoptosis	6.61248443494027e-06	-11.9265511146669	50	29	0.0127416520210896	2276	8202	5689,5693,7311,5692,5702,5695,5713,5682,5710,5715,9491,5691,7316,5687,5696,5707,5719,6233,5714,5709,5690,5717,9861,7314,10197,5705,5700,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,PSMA6,PSMB8,PSMD1,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,PSMB6
R-HSA-72165	mRNA Splicing - Minor Pathway	6.61248443494027e-06	-11.9265511146669	50	29	0.0127416520210896	2276	8202	10594,4809,23020,55599,5440,6431,51639,6635,10081,10907,5430,83443,6426,23450,2962,9416,10992,5432,55954,4686,9343,5434,2963,4904,11066,6637,24148,6633,5431	PRPF8,SNU13,SNRNP200,RNPC3,POLR2K,SRSF6,SF3B6,SNRPE,PDCD7,TXNL4A,POLR2A,SF3B5,SRSF1,SF3B3,GTF2F1,DDX23,SF3B2,POLR2C,ZMAT5,NCBP1,EFTUD2,POLR2E,GTF2F2,YBX1,SNRNP35,SNRPG,PRPF6,SNRPD2,POLR2B
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	6.61248443494027e-06	-11.9265511146669	50	29	0.0127416520210896	2276	8202	11338,23511,8480,6431,10250,9939,10921,53371,10482,9631,6430,8021,23165,129401,6426,5903,4686,4927,10189,55746,7307,6429,23636,9972,6428,1977,9818,8086,9785	U2AF2,NUP188,RAE1,SRSF6,SRRM1,RBM8A,RNPS1,NUP54,NXF1,NUP155,SRSF5,NUP214,NUP205,NUP35,SRSF1,RANBP2,NCBP1,NUP88,ALYREF,NUP133,U2AF1,SRSF4,NUP62,NUP153,SRSF3,EIF4E,NUP58,AAAS,DHX38
R-HSA-674695	RNA Polymerase II Pre-transcription Events	7.62455931713628e-06	-11.7841360316149	65	35	0.015377855887522	2276	8202	9150,6884,5440,6872,6908,2071,2962,8178,2968,83860,2963,2965,6882,6917,2068,2960,2959,5431,6881,6877,902,7936,6921,2958,6875,6829,7469,5430,11198,5432,6873,4686,5434,6883,6878	CTDP1,TAF13,POLR2K,TAF1,TBP,ERCC3,GTF2F1,ELL,GTF2H4,TAF3,GTF2F2,GTF2H1,TAF11,TCEA1,ERCC2,GTF2E1,GTF2B,POLR2B,TAF10,TAF5,CCNH,NELFE,TCEB1,GTF2A2,TAF4B,SUPT5H,NELFA,POLR2A,SUPT16H,POLR2C,TAF2,NCBP1,POLR2E,TAF12,TAF6
R-HSA-5693567	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	8.41567502193368e-06	-11.6854145170284	129	59	0.0259226713532513	2276	8202	5883,8367,83990,29086,144715,1111,641,7329,5424,8347,8360,7341,8365,6118,5111,890,8364,7516,6047,84126,545,7314,57804,3017,2067,5984,5810,7311,5983,11073,51548,5531,85236,7156,5893,9025,5884,8340,8363,8368,10714,5982,7316,9156,5889,8362,675,7336,7158,6233,3014,51720,7517,165918,5981,128312,348654,7334,5425	RAD9A,HIST1H4E,BRIP1,BABAM1,RAD9B,CHEK1,BLM,UBE2I,POLD1,HIST1H2BC,HIST1H4D,SUMO1,HIST1H4H,RPA2,PCNA,CCNA2,HIST1H4C,XRCC2,RNF4,ATRIP,ATR,UBB,POLD4,HIST1H2BD,ERCC1,RFC4,RAD1,UBA52,RFC3,TOPBP1,SIRT6,PPP4C,HIST1H2BK,TOP3A,RAD52,RNF8,RAD17,HIST1H2BL,HIST1H4J,HIST1H4L,POLD3,RFC2,UBC,EXO1,RAD51C,HIST1H4K,BRCA2,UBE2V2,TP53BP1,RPS27A,H2AFX,UIMC1,XRCC3,RNF168,RFC1,HIST3H2BB,GEN1,UBE2N,POLD2
R-HSA-180585	Vif-mediated degradation of APOBEC3G	9.04514989686685e-06	-11.6132818669086	53	30	0.0131810193321617	2276	8202	5689,5693,7311,5692,5702,5695,5713,5682,6921,5710,5715,9491,5691,7316,5696,5687,5707,5719,6233,5714,5709,5690,5717,9861,5705,7314,10197,5700,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,TCEB1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,PSMB8,PSMA6,PSMD1,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,PSMD6,PSMC5,UBB,PSME3,PSMC1,PSMA5,PSMB6
R-HSA-5628897	TP53 Regulates Metabolic Genes	9.05816989651184e-06	-11.6118434564913	73	38	0.0166959578207381	2276	8202	5564,51204,2475,5565,5562,7157,54205,7531,51241,54541,9997,57103,84987,1337,28956,1349,285521,64223,7296,1350,208,1353,5571,10971,6009,5052,7532,2744,7248,51422,389541,9167,1351,10128,9377,7534,7533,1340	PRKAB1,TACO1,MTOR,PRKAB2,PRKAA1,TP53,CYCS,YWHAE,COX16,DDIT4,SCO2,TIGAR,COX14,COX6A1,LAMTOR2,COX7B,COX18,MLST8,TXNRD1,COX7C,AKT2,COX11,PRKAG1,YWHAQ,RHEB,PRDX1,YWHAG,GLS,TSC1,PRKAG2,LAMTOR4,COX7A2L,COX8A,LRPPRC,COX5A,YWHAZ,YWHAH,COX6B1
R-HSA-3700989	Transcriptional Regulation by TP53	9.05816989651184e-06	-11.6118434564913	73	38	0.0166959578207381	2276	8202	5564,51204,2475,5565,5562,7157,54205,7531,51241,54541,9997,57103,84987,1337,28956,1349,285521,64223,7296,1350,208,1353,5571,10971,6009,5052,7532,2744,7248,51422,389541,9167,1351,10128,9377,7534,7533,1340	PRKAB1,TACO1,MTOR,PRKAB2,PRKAA1,TP53,CYCS,YWHAE,COX16,DDIT4,SCO2,TIGAR,COX14,COX6A1,LAMTOR2,COX7B,COX18,MLST8,TXNRD1,COX7C,AKT2,COX11,PRKAG1,YWHAQ,RHEB,PRDX1,YWHAG,GLS,TSC1,PRKAG2,LAMTOR4,COX7A2L,COX8A,LRPPRC,COX5A,YWHAZ,YWHAH,COX6B1
R-HSA-4641258	Degradation of DVL	1.1937572171673e-05	-11.3358198063811	56	31	0.0136203866432337	2276	8202	5689,5693,7311,5692,5702,5695,5713,5682,5710,5715,9491,5691,7316,5707,5687,5696,5719,6233,5714,5709,5690,5717,9861,7314,10197,5705,59349,5700,1856,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,PSMD6,UBB,PSME3,PSMC5,KLHL12,PSMC1,DVL2,PSMA5,PSMB6
R-HSA-68875	Mitotic Prophase	1.27266183804876e-05	-11.2718148224367	136	61	0.0268014059753954	2276	8202	3015,23511,8367,8480,53371,2029,8350,64900,8347,8360,23165,129401,4000,8365,4927,2010,4001,5518,55746,387893,8364,81876,653604,9972,29781,3017,8331,10051,7112,8615,723790,140609,23133,85236,9631,3021,8340,8363,5861,8368,8021,983,84930,5903,3012,8362,23310,2801,23592,7444,91754,3014,23636,10776,128312,54892,7443,9133,255919,9818,8086	H2AFZ,NUP188,HIST1H4E,RAE1,NUP54,ENSA,HIST1H3A,LPIN3,HIST1H2BC,HIST1H4D,NUP205,NUP35,LMNA,HIST1H4H,NUP88,EMD,LMNB1,PPP2R1A,NUP133,KMT5A,HIST1H4C,RAB1B,HIST2H3D,NUP153,NCAPH2,HIST1H2BD,HIST1H2AJ,SMC4,TMPO,USO1,HIST2H2AA4,NEK7,PHF8,HIST1H2BK,NUP155,H3F3B,HIST1H2BL,HIST1H4J,RAB1A,HIST1H4L,NUP214,CDK1,MASTL,RANBP2,HIST1H2AE,HIST1H4K,NCAPD3,GOLGA2,LEMD3,VRK2,NEK9,H2AFX,NUP62,ARPP19,HIST3H2BB,NCAPG2,VRK1,CCNB2,CNEP1R1,NUP58,AAAS
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	1.38339645350474e-05	-11.1883837913971	24	17	0.00746924428822496	2276	8202	10802,10484,6396,9871,3133,3134,3309,6890,567,821,3105,811,22872,51128,9632,51752,3107	SEC24A,SEC23A,SEC13,SEC24D,HLA-E,HLA-F,HSPA5,TAP1,B2M,CANX,HLA-A,CALR,SEC31A,SAR1B,SEC24C,ERAP1,HLA-C
R-HSA-5693532	DNA Double-Strand Break Repair	1.4528731584891e-05	-11.1393823804837	162	70	0.0307557117750439	2276	8202	5883,9682,83990,7157,7329,5424,8365,5111,890,8364,7516,84126,3017,2237,2067,5984,5983,5810,7311,51548,10038,85236,5884,8340,5982,9156,5889,8362,675,23030,7336,7158,6233,2547,3014,9031,51720,7517,165918,11200,5981,128312,348654,7334,8367,144715,29086,55183,1111,641,8347,8360,7341,6118,6047,545,7314,57804,11073,5531,7156,5893,8363,9025,8368,10714,7316,7515,7520,5425	RAD9A,KDM4A,BRIP1,TP53,UBE2I,POLD1,HIST1H4H,PCNA,CCNA2,HIST1H4C,XRCC2,ATRIP,HIST1H2BD,FEN1,ERCC1,RFC4,RFC3,RAD1,UBA52,SIRT6,PARP2,HIST1H2BK,RAD17,HIST1H2BL,RFC2,EXO1,RAD51C,HIST1H4K,BRCA2,KDM4B,UBE2V2,TP53BP1,RPS27A,XRCC6,H2AFX,BAZ1B,UIMC1,XRCC3,RNF168,CHEK2,RFC1,HIST3H2BB,GEN1,UBE2N,HIST1H4E,RAD9B,BABAM1,RIF1,CHEK1,BLM,HIST1H2BC,HIST1H4D,SUMO1,RPA2,RNF4,ATR,UBB,POLD4,TOPBP1,PPP4C,TOP3A,RAD52,HIST1H4J,RNF8,HIST1H4L,POLD3,UBC,XRCC1,XRCC5,POLD2
R-HSA-76046	RNA Polymerase III Transcription Initiation	1.47639990610805e-05	-11.1233188363917	35	22	0.00966608084358524	2276	8202	5440,9328,6908,171568,55814,5451,7702,6618,51728,11128,661,51082,55290,5434,9329,9330,2972,55703,6619,10302,6617,10621	POLR2K,GTF3C5,TBP,POLR3H,BDP1,POU2F1,ZNF143,SNAPC2,POLR3K,POLR3A,POLR3D,POLR1D,BRF2,POLR2E,GTF3C4,GTF3C3,BRF1,POLR3B,SNAPC3,SNAPC5,SNAPC1,POLR3F
R-HSA-5358346	Hedgehog ligand biogenesis	1.50888383170939e-05	-11.1015552717732	64	34	0.0149384885764499	2276	8202	5689,5693,5713,5715,9491,5707,5687,5696,5034,5717,7314,5686,5694,7311,6868,5692,5702,5695,5682,84447,5710,7415,7316,5691,5719,6233,5709,5714,6400,5690,10197,9861,5705,5700	PSMB1,PSMB5,PSMD7,PSMD9,PSMF1,PSMD1,PSMA6,PSMB8,P4HB,PSMD11,UBB,PSMA5,PSMB6,UBA52,ADAM17,PSMB4,PSMC3,PSMB7,PSMA1,SYVN1,PSMD4,VCP,UBC,PSMB3,PSMD13,RPS27A,PSMD3,PSMD8,SEL1L,PSMB2,PSME3,PSMD6,PSMC5,PSMC1
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	1.92662952532202e-05	-10.8571533486544	57	31	0.0136203866432337	2276	8202	5689,5693,7311,5692,5702,7157,5695,5713,5682,5710,5715,9491,5691,7316,5707,5687,5696,5719,6233,5714,5709,5690,1027,5717,9861,7314,10197,5705,5700,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,TP53,PSMB7,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,CDKN1B,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,PSMB6
R-HSA-69563	p53-Dependent G1 DNA Damage Response	1.92662952532202e-05	-10.8571533486544	57	31	0.0136203866432337	2276	8202	5689,5693,7311,5692,5702,7157,5695,5713,5682,5710,5715,9491,5691,7316,5707,5687,5696,5719,6233,5714,5709,5690,1027,5717,9861,7314,10197,5705,5700,5686,5694	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,TP53,PSMB7,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,PSMB3,UBC,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,CDKN1B,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,PSMA5,PSMB6
R-HSA-5607764	CLEC7A (Dectin-1) signaling	2.08188197478371e-05	-10.7796531847687	99	47	0.0206502636203866	2276	8202	23291,5689,5693,257397,5713,1147,5715,9491,805,5707,5687,5696,3551,5971,5717,6885,4791,7314,10768,5970,5686,5694,5170,7311,5692,5702,5695,10892,5682,7335,5710,5691,7316,8517,5719,6233,5714,5709,7322,5690,5705,9861,10197,10454,5700,7334,8945	FBXW11,PSMB1,PSMB5,TAB3,PSMD7,CHUK,PSMD9,PSMF1,CALM2,PSMD1,PSMA6,PSMB8,IKBKB,RELB,PSMD11,MAP3K7,NFKB2,UBB,AHCYL1,RELA,PSMA5,PSMB6,PDPK1,UBA52,PSMB4,PSMC3,PSMB7,MALT1,PSMA1,UBE2V1,PSMD4,PSMB3,UBC,IKBKG,PSMD13,RPS27A,PSMD8,PSMD3,UBE2D2,PSMB2,PSMC5,PSMD6,PSME3,TAB1,PSMC1,UBE2N,BTRC
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	2.357081838749e-05	-10.6555011200454	50	28	0.0123022847100176	2276	8202	5689,5693,5692,1728,5702,5695,5713,5682,51686,5710,5715,9491,5691,5707,5687,5696,5719,5714,5709,51582,5690,5717,9861,10197,5705,5700,5686,5694	PSMB1,PSMB5,PSMB4,NQO1,PSMC3,PSMB7,PSMD7,PSMA1,OAZ3,PSMD4,PSMD9,PSMF1,PSMB3,PSMD1,PSMA6,PSMB8,PSMD13,PSMD8,PSMD3,AZIN1,PSMB2,PSMD11,PSMD6,PSME3,PSMC5,PSMC1,PSMA5,PSMB6
R-HSA-3371556	Cellular response to heat stress	2.41883206950885e-05	-10.6296406572036	86	42	0.0184534270650264	2276	8202	10808,23511,6767,2475,8480,53371,84335,3337,7531,10013,91582,1915,23165,129401,6118,4927,55746,10049,9972,545,6782,3320,10728,64223,23411,3326,3312,3309,57805,9631,8021,51501,7415,3304,5903,817,3308,3313,2932,23636,9818,8086	HSPH1,NUP188,ST13,MTOR,RAE1,NUP54,AKT1S1,DNAJB1,YWHAE,HDAC6,RPS19BP1,EEF1A1,NUP205,NUP35,RPA2,NUP88,NUP133,DNAJB6,NUP153,ATR,HSPA13,HSP90AA1,PTGES3,MLST8,SIRT1,HSP90AB1,HSPA8,HSPA5,CCAR2,NUP155,NUP214,C11orf73,VCP,HSPA1B,RANBP2,CAMK2D,HSPA4,HSPA9,GSK3B,NUP62,NUP58,AAAS
R-HSA-73886	Chromosome Maintenance	2.48831102730648e-05	-10.6013212869312	105	49	0.0215289982425308	2276	8202	23649,3015,8367,3978,4869,51773,55651,5424,55320,8347,8360,79172,91687,8365,54386,6118,5111,65057,8364,26277,79019,57804,3017,8331,2237,7014,5984,1058,5983,5931,723790,5422,85236,8340,8363,8368,10714,5982,79682,401541,3012,8362,8607,3014,5981,128312,57082,5425,55135	POLA2,H2AFZ,HIST1H4E,LIG1,NPM1,RSF1,NHP2,POLD1,MIS18BP1,HIST1H2BC,HIST1H4D,CENPO,CENPL,HIST1H4H,TERF2IP,RPA2,PCNA,ACD,HIST1H4C,TINF2,CENPM,POLD4,HIST1H2BD,HIST1H2AJ,FEN1,TERF2,RFC4,CENPA,RFC3,RBBP7,HIST2H2AA4,POLA1,HIST1H2BK,HIST1H2BL,HIST1H4J,HIST1H4L,POLD3,RFC2,CENPU,CENPP,HIST1H2AE,HIST1H4K,RUVBL1,H2AFX,RFC1,HIST3H2BB,CASC5,POLD2,WRAP53
R-HSA-5693607	Processing of DNA double-strand break ends	2.63170341444929e-05	-10.5452941423363	97	46	0.0202108963093146	2276	8202	5883,8367,83990,29086,144715,1111,641,7329,8347,8360,7341,8365,6118,890,8364,6047,84126,545,7314,3017,5984,5810,7311,5983,11073,51548,5531,7156,85236,9025,5884,8340,8363,8368,5982,7316,9156,8362,7336,7158,6233,3014,51720,165918,128312,7334	RAD9A,HIST1H4E,BRIP1,BABAM1,RAD9B,CHEK1,BLM,UBE2I,HIST1H2BC,HIST1H4D,SUMO1,HIST1H4H,RPA2,CCNA2,HIST1H4C,RNF4,ATRIP,ATR,UBB,HIST1H2BD,RFC4,RAD1,UBA52,RFC3,TOPBP1,SIRT6,PPP4C,TOP3A,HIST1H2BK,RNF8,RAD17,HIST1H2BL,HIST1H4J,HIST1H4L,RFC2,UBC,EXO1,HIST1H4K,UBE2V2,TP53BP1,RPS27A,H2AFX,UIMC1,RNF168,HIST3H2BB,UBE2N
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	2.71324912262679e-05	-10.5147786099924	89	43	0.0188927943760984	2276	8202	23291,3146,1848,257397,5604,30849,4205,1147,9252,8411,5606,3725,466,6196,5518,3551,5601,6885,4791,5598,7314,1386,5970,7311,5289,8767,5609,7867,51295,7335,246330,2002,2353,7316,8517,64145,6233,5608,10454,5528,170506,7334,8945	FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,PIK3R4,MEF2A,CHUK,RPS6KA5,EEA1,MAP2K3,JUN,ATF1,RPS6KA2,PPP2R1A,IKBKB,MAPK9,MAP3K7,NFKB2,MAPK7,UBB,ATF2,RELA,UBA52,PIK3C3,RIPK2,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,PELI3,ELK1,FOS,UBC,IKBKG,RBSN,RPS27A,MAP2K6,TAB1,PPP2R5D,DHX36,UBE2N,BTRC
R-HSA-199977	ER to Golgi Anterograde Transport	2.78608292200991e-05	-10.4882888262329	68	35	0.015377855887522	2276	8202	6396,9871,26984,9919,9117,966,9632,81876,5537,51399,10960,10342,22870,10959,6811,10113,10802,10484,8615,23256,375056,10282,1294,5861,90411,22872,51128,11196,27095,2801,10972,4253,9554,55291,79090	SEC13,SEC24D,SEC22A,SEC16A,SEC22C,CD59,SEC24C,RAB1B,PPP6C,TRAPPC4,LMAN2,TFG,PPP6R1,TMED2,STX5,PREB,SEC24A,SEC23A,USO1,SCFD1,MIA3,BET1,COL7A1,RAB1A,MCFD2,SEC31A,SAR1B,SEC23IP,TRAPPC3,GOLGA2,TMED10,CTAGE5,SEC22B,PPP6R3,TRAPPC6A
R-HSA-75893	TNF signaling	3.35252452260893e-05	-10.3032118141003	41	24	0.0105448154657293	2276	8202	6868,7375,1540,7311,7128,330,257397,7186,8887,1147,10399,27005,329,7316,8772,55512,8517,6233,55072,3551,6885,7314,10454,90268	ADAM17,USP4,CYLD,UBA52,TNFAIP3,BIRC3,TAB3,TRAF2,TAX1BP1,CHUK,GNB2L1,USP21,BIRC2,UBC,FADD,SMPD3,IKBKG,RPS27A,RNF31,IKBKB,MAP3K7,UBB,TAB1,OTULIN
R-HSA-429947	Deadenylation of mRNA	3.58046979671369e-05	-10.237431445035	23	16	0.0070298769771529	2276	8202	1975,23019,9337,1974,1973,29883,85456,55571,4849,9924,4848,9125,25904,9775,1977,26986	EIF4B,CNOT1,CNOT8,EIF4A2,EIF4A1,CNOT7,TNKS1BP1,CNOT11,CNOT3,PAN2,CNOT2,RQCD1,CNOT10,EIF4A3,EIF4E,PABPC1
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	3.58046979671369e-05	-10.237431445035	23	16	0.0070298769771529	2276	8202	5984,5983,7311,3978,10714,5982,5424,7515,7316,6118,5111,6233,5981,7314,57804,5425	RFC4,RFC3,UBA52,LIG1,POLD3,RFC2,POLD1,XRCC1,UBC,RPA2,PCNA,RPS27A,RFC1,UBB,POLD4,POLD2
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	3.69680940428001e-05	-10.2054553405021	46	26	0.0114235500878735	2276	8202	6881,6884,6877,902,5440,6872,6908,2071,2958,6875,5430,2962,6873,5432,2968,83860,5434,2963,2965,6882,2960,6883,2068,2959,6878,5431	TAF10,TAF13,TAF5,CCNH,POLR2K,TAF1,TBP,ERCC3,GTF2A2,TAF4B,POLR2A,GTF2F1,TAF2,POLR2C,GTF2H4,TAF3,POLR2E,GTF2F2,GTF2H1,TAF11,GTF2E1,TAF12,ERCC2,GTF2B,TAF6,POLR2B
R-HSA-73776	RNA Polymerase II Promoter Escape	3.69680940428001e-05	-10.2054553405021	46	26	0.0114235500878735	2276	8202	6881,6884,6877,902,5440,6872,6908,2071,2958,6875,5430,2962,6873,5432,2968,83860,5434,2963,2965,6882,2960,6883,2068,2959,6878,5431	TAF10,TAF13,TAF5,CCNH,POLR2K,TAF1,TBP,ERCC3,GTF2A2,TAF4B,POLR2A,GTF2F1,TAF2,POLR2C,GTF2H4,TAF3,POLR2E,GTF2F2,GTF2H1,TAF11,GTF2E1,TAF12,ERCC2,GTF2B,TAF6,POLR2B
R-HSA-167161	HIV Transcription Initiation	3.69680940428001e-05	-10.2054553405021	46	26	0.0114235500878735	2276	8202	6884,6881,6877,902,6872,2071,5440,6908,6875,2958,5430,2962,5432,6873,2968,83860,5434,2963,2965,2960,6882,6883,2068,2959,6878,5431	TAF13,TAF10,TAF5,CCNH,TAF1,ERCC3,POLR2K,TBP,TAF4B,GTF2A2,POLR2A,GTF2F1,POLR2C,TAF2,GTF2H4,TAF3,POLR2E,GTF2F2,GTF2H1,GTF2E1,TAF11,TAF12,ERCC2,GTF2B,TAF6,POLR2B
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	3.69680940428001e-05	-10.2054553405021	46	26	0.0114235500878735	2276	8202	6881,6884,6877,902,5440,6872,6908,2071,2958,6875,5430,2962,6873,5432,2968,83860,5434,2963,2965,6882,2960,6883,2068,2959,6878,5431	TAF10,TAF13,TAF5,CCNH,POLR2K,TAF1,TBP,ERCC3,GTF2A2,TAF4B,POLR2A,GTF2F1,TAF2,POLR2C,GTF2H4,TAF3,POLR2E,GTF2F2,GTF2H1,TAF11,GTF2E1,TAF12,ERCC2,GTF2B,TAF6,POLR2B
R-HSA-75953	RNA Polymerase II Transcription Initiation	3.69680940428001e-05	-10.2054553405021	46	26	0.0114235500878735	2276	8202	6881,6884,6877,902,5440,6872,6908,2071,2958,6875,5430,2962,6873,5432,2968,83860,5434,2963,2965,6882,2960,6883,2068,2959,6878,5431	TAF10,TAF13,TAF5,CCNH,POLR2K,TAF1,TBP,ERCC3,GTF2A2,TAF4B,POLR2A,GTF2F1,TAF2,POLR2C,GTF2H4,TAF3,POLR2E,GTF2F2,GTF2H1,TAF11,GTF2E1,TAF12,ERCC2,GTF2B,TAF6,POLR2B
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	3.69680940428001e-05	-10.2054553405021	46	26	0.0114235500878735	2276	8202	6884,6881,6877,902,6872,2071,5440,6908,6875,2958,5430,2962,5432,6873,2968,83860,5434,2963,2965,2960,6882,6883,2068,2959,6878,5431	TAF13,TAF10,TAF5,CCNH,TAF1,ERCC3,POLR2K,TBP,TAF4B,GTF2A2,POLR2A,GTF2F1,POLR2C,TAF2,GTF2H4,TAF3,POLR2E,GTF2F2,GTF2H1,GTF2E1,TAF11,TAF12,ERCC2,GTF2B,TAF6,POLR2B
R-HSA-69298	Association of licensing factors with the pre-replicative complex	3.84561946135718e-05	-10.1659907667038	15	12	0.00527240773286467	2276	8202	4999,7311,5000,6233,5001,1871,990,4998,7314,23595,1870,7316	ORC2,UBA52,ORC4,RPS27A,ORC5,E2F3,CDC6,ORC1,UBB,ORC3,E2F2,UBC
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	4.86847882276958e-05	-9.93014393339008	54	29	0.0127416520210896	2276	8202	3150,7311,902,9318,5440,57461,2071,56949,7316,5430,5432,50813,51138,2968,2074,6233,8533,10987,5434,57654,2965,6917,9716,2068,7314,91603,5431,1642,27339	HMGN1,UBA52,CCNH,COPS2,POLR2K,ISY1,ERCC3,XAB2,UBC,POLR2A,POLR2C,COPS7A,COPS4,GTF2H4,ERCC6,RPS27A,COPS3,COPS5,POLR2E,UVSSA,GTF2H1,TCEA1,AQR,ERCC2,UBB,ZNF830,POLR2B,DDB1,PRPF19
R-HSA-5658442	Regulation of RAS by GAPs	5.27776091152321e-05	-9.84942352698235	67	34	0.0149384885764499	2276	8202	200734,161742,5689,5693,4763,5713,5715,9491,5687,5696,5707,5717,7314,5686,5694,7311,5692,5702,5695,5682,3845,5710,7316,5691,5719,6233,5709,5714,84078,5690,9861,10197,5705,5700	SPRED2,SPRED1,PSMB1,PSMB5,NF1,PSMD7,PSMD9,PSMF1,PSMA6,PSMB8,PSMD1,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,KRAS,PSMD4,UBC,PSMB3,PSMD13,RPS27A,PSMD3,PSMD8,KBTBD7,PSMB2,PSMD6,PSME3,PSMC5,PSMC1
R-HSA-73856	RNA Polymerase II Transcription Termination	5.77580192306409e-05	-9.75924835706605	42	24	0.0105448154657293	2276	8202	11338,6431,10250,9939,10978,10921,7884,6635,51585,6430,6426,11051,4686,25888,10189,7307,6429,1478,6428,6637,51692,84967,9785,1477	U2AF2,SRSF6,SRRM1,RBM8A,CLP1,RNPS1,SLBP,SNRPE,PCF11,SRSF5,SRSF1,NUDT21,NCBP1,ZNF473,ALYREF,U2AF1,SRSF4,CSTF2,SRSF3,SNRPG,CPSF3,LSM10,DHX38,CSTF1
R-HSA-109688	Cleavage of Growing Transcript in the Termination Region	5.77580192306409e-05	-9.75924835706605	42	24	0.0105448154657293	2276	8202	11338,6431,10250,9939,10978,10921,7884,6635,51585,6430,6426,11051,4686,25888,10189,7307,6429,1478,6428,6637,51692,84967,9785,1477	U2AF2,SRSF6,SRRM1,RBM8A,CLP1,RNPS1,SLBP,SNRPE,PCF11,SRSF5,SRSF1,NUDT21,NCBP1,ZNF473,ALYREF,U2AF1,SRSF4,CSTF2,SRSF3,SNRPG,CPSF3,LSM10,DHX38,CSTF1
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	5.83765693463392e-05	-9.74859595845925	28	18	0.00790861159929701	2276	8202	5984,5983,7311,10714,5982,5424,7316,6118,5111,56852,6233,7320,7398,5981,7314,57804,1642,5425	RFC4,RFC3,UBA52,POLD3,RFC2,POLD1,UBC,RPA2,PCNA,RAD18,RPS27A,UBE2B,USP1,RFC1,UBB,POLD4,DDB1,POLD2
R-HSA-76071	RNA Polymerase III Transcription Initiation From Type 3 Promoter	5.83765693463392e-05	-9.74859595845925	28	18	0.00790861159929701	2276	8202	661,5440,51082,6908,171568,55290,55814,5434,5451,7702,6619,55703,6618,51728,10302,11128,10621,6617	POLR3D,POLR2K,POLR1D,TBP,POLR3H,BRF2,BDP1,POLR2E,POU2F1,ZNF143,SNAPC3,POLR3B,SNAPC2,POLR3K,SNAPC5,POLR3A,POLR3F,SNAPC1
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	6.12142321042814e-05	-9.70113084475817	70	35	0.015377855887522	2276	8202	23511,8480,53371,8672,51191,5495,4734,23165,129401,4927,9775,55746,5300,9972,7314,1977,3837,25820,7311,3841,11274,1974,1973,9631,1982,8021,7316,5903,3840,6233,6772,23636,7334,9818,8086	NUP188,RAE1,NUP54,EIF4G3,HERC5,PPM1B,NEDD4,NUP205,NUP35,NUP88,EIF4A3,NUP133,PIN1,NUP153,UBB,EIF4E,KPNB1,ARIH1,UBA52,KPNA5,USP18,EIF4A2,EIF4A1,NUP155,EIF4G2,NUP214,UBC,RANBP2,KPNA4,RPS27A,STAT1,NUP62,UBE2N,NUP58,AAAS
R-HSA-1169408	ISG15 antiviral mechanism	6.12142321042814e-05	-9.70113084475817	70	35	0.015377855887522	2276	8202	23511,8480,53371,8672,51191,5495,4734,23165,129401,4927,9775,55746,5300,9972,7314,1977,3837,25820,7311,3841,11274,1974,1973,9631,1982,8021,7316,5903,3840,6233,6772,23636,7334,9818,8086	NUP188,RAE1,NUP54,EIF4G3,HERC5,PPM1B,NEDD4,NUP205,NUP35,NUP88,EIF4A3,NUP133,PIN1,NUP153,UBB,EIF4E,KPNB1,ARIH1,UBA52,KPNA5,USP18,EIF4A2,EIF4A1,NUP155,EIF4G2,NUP214,UBC,RANBP2,KPNA4,RPS27A,STAT1,NUP62,UBE2N,NUP58,AAAS
R-HSA-68877	Mitotic Prometaphase	6.18242911740189e-05	-9.69121420966063	108	49	0.0215289982425308	2276	8202	6396,1063,55143,1460,5526,11004,64151,55055,79172,79003,91687,9918,9183,5518,151246,55746,8379,9735,79019,10051,10726,11130,1058,10274,348235,991,6232,701,9212,983,79682,401541,3796,5903,5529,7514,79980,25936,332,4085,8243,5527,147841,1062,23122,57082,151648,9133,5528	SEC13,CENPF,CDCA8,CSNK2B,PPP2R5B,KIF2C,NCAPG,ZWILCH,CENPO,MIS12,CENPL,NCAPD2,ZW10,PPP2R1A,SGOL2,NUP133,MAD1L1,KNTC1,CENPM,SMC4,NUDC,ZWINT,CENPA,STAG1,SKA2,CDC20,RPS27,BUB1B,AURKB,CDK1,CENPU,CENPP,KIF2A,RANBP2,PPP2R5E,XPO1,DSN1,NSL1,BIRC5,MAD2L1,SMC1A,PPP2R5C,SPC24,CENPE,CLASP2,CASC5,SGOL1,CCNB2,PPP2R5D
R-HSA-157579	Telomere Maintenance	6.24058798108921e-05	-9.68185105928939	78	38	0.0166959578207381	2276	8202	23649,3015,8367,3978,55651,5424,8347,8360,8365,54386,6118,5111,65057,8364,26277,57804,3017,8331,2237,7014,5984,5983,723790,5422,85236,8340,8363,8368,10714,5982,8362,3012,8607,3014,5981,128312,55135,5425	POLA2,H2AFZ,HIST1H4E,LIG1,NHP2,POLD1,HIST1H2BC,HIST1H4D,HIST1H4H,TERF2IP,RPA2,PCNA,ACD,HIST1H4C,TINF2,POLD4,HIST1H2BD,HIST1H2AJ,FEN1,TERF2,RFC4,RFC3,HIST2H2AA4,POLA1,HIST1H2BK,HIST1H2BL,HIST1H4J,HIST1H4L,POLD3,RFC2,HIST1H4K,HIST1H2AE,RUVBL1,H2AFX,RFC1,HIST3H2BB,WRAP53,POLD2
R-HSA-5696400	Dual Incision in GG-NER	7.20618959331418e-05	-9.53798514251109	40	23	0.0101054481546573	2276	8202	5984,1643,2067,5983,7311,2071,10038,10714,5982,5424,7316,6118,5111,2968,6233,2965,2073,5981,2068,7314,57804,5425,1642	RFC4,DDB2,ERCC1,RFC3,UBA52,ERCC3,PARP2,POLD3,RFC2,POLD1,UBC,RPA2,PCNA,GTF2H4,RPS27A,GTF2H1,ERCC5,RFC1,ERCC2,UBB,POLD4,POLD2,DDB1
R-HSA-450294	MAP kinase activation in TLR cascade	7.20682069673719e-05	-9.5378975683804	60	31	0.0136203866432337	2276	8202	23291,7311,1848,5609,8767,257397,7867,5604,4205,1147,2002,2353,9252,5606,7316,3725,466,8517,6196,5518,6233,5608,3551,5601,6885,7314,5598,10454,1386,5528,8945	FBXW11,UBA52,DUSP6,MAP2K7,RIPK2,TAB3,MAPKAPK3,MAP2K1,MEF2A,CHUK,ELK1,FOS,RPS6KA5,MAP2K3,UBC,JUN,ATF1,IKBKG,RPS6KA2,PPP2R1A,RPS27A,MAP2K6,IKBKB,MAPK9,MAP3K7,UBB,MAPK7,TAB1,ATF2,PPP2R5D,BTRC
R-HSA-2980766	Nuclear Envelope Breakdown	7.77671974998321e-05	-9.46179084165532	50	27	0.0118629173989455	2276	8202	23511,140609,8480,53371,9631,64900,8021,983,23165,129401,4000,5903,4927,2010,4001,55746,23592,7444,91754,23636,9972,9133,7443,255919,9818,8086,7112	NUP188,NEK7,RAE1,NUP54,NUP155,LPIN3,NUP214,CDK1,NUP205,NUP35,LMNA,RANBP2,NUP88,EMD,LMNB1,NUP133,LEMD3,VRK2,NEK9,NUP62,NUP153,CCNB2,VRK1,CNEP1R1,NUP58,AAAS,TMPO
R-HSA-4608870	Asymmetric localization of PCP proteins	8.50249284347726e-05	-9.37256606876766	63	32	0.0140597539543058	2276	8202	5689,5693,7311,5692,5702,5695,5713,5682,5710,2535,5715,9491,5691,7316,5707,5687,5696,5719,6233,5714,5709,5690,5717,9861,7314,10197,5705,5700,1856,5686,5694,8321	PSMB1,PSMB5,UBA52,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,PSMD4,FZD2,PSMD9,PSMF1,PSMB3,UBC,PSMD1,PSMA6,PSMB8,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD11,PSMD6,UBB,PSME3,PSMC5,PSMC1,DVL2,PSMA5,PSMB6,FZD1
R-HSA-204005	COPII (Coat Protein 2) Mediated Vesicle Transport	9.86365809806258e-05	-9.2240683613003	66	33	0.0144991212653779	2276	8202	6396,9871,26984,9919,9117,966,9632,81876,5537,51399,10960,10342,22870,10959,6811,10113,10802,10484,8615,23256,10282,1294,5861,90411,22872,51128,11196,27095,2801,10972,9554,55291,79090	SEC13,SEC24D,SEC22A,SEC16A,SEC22C,CD59,SEC24C,RAB1B,PPP6C,TRAPPC4,LMAN2,TFG,PPP6R1,TMED2,STX5,PREB,SEC24A,SEC23A,USO1,SCFD1,BET1,COL7A1,RAB1A,MCFD2,SEC31A,SAR1B,SEC23IP,TRAPPC3,GOLGA2,TMED10,SEC22B,PPP6R3,TRAPPC6A
R-HSA-176974	Unwinding of DNA	9.87804002162703e-05	-9.22261135126788	12	10	0.00439367311072056	2276	8202	9837,4173,8318,4175,4174,84515,4171,4176,4172,84296	GINS1,MCM4,CDC45,MCM6,MCM5,MCM8,MCM2,MCM7,MCM3,GINS4
R-HSA-202424	Downstream TCR signaling	0.000107834013931919	-9.1349174211325	96	44	0.0193321616871705	2276	8202	3122,23291,5689,5693,5713,1147,5715,9491,5707,5687,5696,3551,5296,5717,6885,7314,5970,5686,5694,5170,7311,8767,5692,5702,5695,10892,5682,7335,5710,5691,7316,8517,5719,6233,5714,5709,7322,5690,5705,9861,10197,5700,7334,8945	HLA-DRA,FBXW11,PSMB1,PSMB5,PSMD7,CHUK,PSMD9,PSMF1,PSMD1,PSMA6,PSMB8,IKBKB,PIK3R2,PSMD11,MAP3K7,UBB,RELA,PSMA5,PSMB6,PDPK1,UBA52,RIPK2,PSMB4,PSMC3,PSMB7,MALT1,PSMA1,UBE2V1,PSMD4,PSMB3,UBC,IKBKG,PSMD13,RPS27A,PSMD8,PSMD3,UBE2D2,PSMB2,PSMC5,PSMD6,PSME3,PSMC1,UBE2N,BTRC
R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	0.000112052929906054	-9.09653920985702	14	11	0.00483304042179262	2276	8202	6118,9156,5111,4436,3978,4292,10714,57804,5424,5425,2956	RPA2,EXO1,PCNA,MSH2,LIG1,MLH1,POLD3,POLD4,POLD1,POLD2,MSH6
R-HSA-174411	Polymerase switching on the C-strand of the telomere	0.000112052929906054	-9.09653920985702	14	11	0.00483304042179262	2276	8202	23649,5984,5111,5983,5422,5981,10714,57804,5424,5982,5425	POLA2,RFC4,PCNA,RFC3,POLA1,RFC1,POLD3,POLD4,POLD1,RFC2,POLD2
R-HSA-69091	Polymerase switching	0.000112052929906054	-9.09653920985702	14	11	0.00483304042179262	2276	8202	23649,5984,5111,5983,5422,5981,10714,57804,5424,5982,5425	POLA2,RFC4,PCNA,RFC3,POLA1,RFC1,POLD3,POLD4,POLD1,RFC2,POLD2
R-HSA-69109	Leading Strand Synthesis	0.000112052929906054	-9.09653920985702	14	11	0.00483304042179262	2276	8202	23649,5984,5111,5983,5422,5981,10714,57804,5424,5982,5425	POLA2,RFC4,PCNA,RFC3,POLA1,RFC1,POLD3,POLD4,POLD1,RFC2,POLD2
R-HSA-1632852	Macroautophagy	0.000143146759558446	-8.85164016336203	67	33	0.0144991212653779	2276	8202	27243,5564,7405,60673,2475,5565,8655,5562,30849,8678,115201,84938,11337,64422,28956,9776,11152,64223,5289,55054,5571,9140,51652,25978,6009,23710,7248,51422,55062,389541,10533,9474,23192	CHMP2A,PRKAB1,UVRAG,ATG101,MTOR,PRKAB2,DYNLL1,PRKAA1,PIK3R4,BECN1,ATG4A,ATG4C,GABARAP,ATG3,LAMTOR2,ATG13,WDR45,MLST8,PIK3C3,ATG16L1,PRKAG1,ATG12,CHMP3,CHMP2B,RHEB,GABARAPL1,TSC1,PRKAG2,WIPI1,LAMTOR4,ATG7,ATG5,ATG4B
R-HSA-5663220	RHO GTPases Activate Formins	0.000150115648954204	-8.80410456790244	114	50	0.0219683655536028	2276	8202	6396,1063,57591,55143,5526,11004,81624,55055,79172,79003,91687,9183,998,5518,151246,55746,8379,9735,79019,114793,1856,10726,11130,1058,348235,991,6232,701,9212,1729,79682,401541,3796,5903,5529,7514,79980,25936,332,4085,3688,6722,5527,147841,286205,1062,23122,57082,151648,5528	SEC13,CENPF,MKL1,CDCA8,PPP2R5B,KIF2C,DIAPH3,ZWILCH,CENPO,MIS12,CENPL,ZW10,CDC42,PPP2R1A,SGOL2,NUP133,MAD1L1,KNTC1,CENPM,FMNL2,DVL2,NUDC,ZWINT,CENPA,SKA2,CDC20,RPS27,BUB1B,AURKB,DIAPH1,CENPU,CENPP,KIF2A,RANBP2,PPP2R5E,XPO1,DSN1,NSL1,BIRC5,MAD2L1,ITGB1,SRF,PPP2R5C,SPC24,SCAI,CENPE,CLASP2,CASC5,SGOL1,PPP2R5D
R-HSA-6782315	tRNA modification in the nucleus and cytosol	0.000152300707942429	-8.78965364973234	39	22	0.00966608084358524	2276	8202	4234,348180,60487,55621,55253,54888,113179,55644,51504,127253,2058,54482,51002,129450,10785,9836,23536,54901,93587,55039,90353,79691	METTL1,CTU2,TRMT11,TRMT1,TYW1,NSUN2,ADAT3,OSGEP,TRMT112,TYW3,EPRS,TRMT13,TPRKB,TYW5,WDR4,LCMT2,ADAT1,CDKAL1,TRMT10A,TRMT12,CTU1,QTRTD1
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.000154059673109115	-8.7781705428831	100	45	0.0197715289982425	2276	8202	6396,1063,55143,5526,11004,55055,79172,79003,91687,9183,5518,151246,55746,8379,9735,79019,10726,1058,11130,10274,348235,991,6232,701,9212,983,79682,401541,3796,5903,5529,7514,25936,79980,332,4085,8243,5527,147841,1062,23122,57082,151648,9133,5528	SEC13,CENPF,CDCA8,PPP2R5B,KIF2C,ZWILCH,CENPO,MIS12,CENPL,ZW10,PPP2R1A,SGOL2,NUP133,MAD1L1,KNTC1,CENPM,NUDC,CENPA,ZWINT,STAG1,SKA2,CDC20,RPS27,BUB1B,AURKB,CDK1,CENPU,CENPP,KIF2A,RANBP2,PPP2R5E,XPO1,NSL1,DSN1,BIRC5,MAD2L1,SMC1A,PPP2R5C,SPC24,CENPE,CLASP2,CASC5,SGOL1,CCNB2,PPP2R5D
R-HSA-1236975	Antigen processing-Cross presentation	0.000171723555969075	-8.6696246068729	81	38	0.0166959578207381	2276	8202	5689,5693,23480,3133,3134,4012,6890,5713,567,5715,9491,3105,811,5707,5687,5696,5717,3107,7314,5686,5694,7311,5692,5702,5695,5682,5710,5691,7316,5719,6233,5709,5714,5690,5705,9861,10197,5700	PSMB1,PSMB5,SEC61G,HLA-E,HLA-F,LNPEP,TAP1,PSMD7,B2M,PSMD9,PSMF1,HLA-A,CALR,PSMD1,PSMA6,PSMB8,PSMD11,HLA-C,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,PSMD4,PSMB3,UBC,PSMD13,RPS27A,PSMD3,PSMD8,PSMB2,PSMC5,PSMD6,PSME3,PSMC1
R-HSA-191273	Cholesterol biosynthesis	0.000194759699064092	-8.54374407181377	23	15	0.00659050966608084	2276	8202	1595,3422,3157,6307,4597,2224,1718,1717,64801,9453,10654,6309,10682,2222,3156	CYP51A1,IDI1,HMGCS1,MSMO1,MVD,FDPS,DHCR24,DHCR7,ARV1,GGPS1,PMVK,SC5D,EBP,FDFT1,HMGCR
R-HSA-68962	Activation of the pre-replicative complex	0.000211526460351158	-8.46116045926	30	18	0.00790861159929701	2276	8202	23649,4999,4175,55388,5422,990,4998,4171,4176,8318,6118,4173,5000,4174,5001,84515,23595,4172	POLA2,ORC2,MCM6,MCM10,POLA1,CDC6,ORC1,MCM2,MCM7,CDC45,RPA2,MCM4,ORC4,MCM5,ORC5,MCM8,ORC3,MCM3
R-HSA-2559585	Oncogene Induced Senescence	0.000211526460351158	-8.46116045926	30	18	0.00790861159929701	2276	8202	1030,23112,7311,3397,1019,7157,1871,7316,2114,6233,7314,4343,1032,1870,1021,1029,192669,6667	CDKN2B,TNRC6B,UBA52,ID1,CDK4,TP53,E2F3,UBC,ETS2,RPS27A,UBB,MOV10,CDKN2D,E2F2,CDK6,CDKN2A,AGO3,SP1
R-HSA-381070	IRE1alpha activates chaperones	0.000221446637215097	-8.41532891301135	55	28	0.0123022847100176	2276	8202	7709,9820,6734,2931,7094,64061,23480,7095,3309,10525,5526,84447,27230,4189,4000,10897,1200,22872,6464,55062,7466,7494,439,55033,9114,116138,1639,10113	ZBTB17,CUL7,SRPR,GSK3A,TLN1,TSPYL2,SEC61G,SEC62,HSPA5,HYOU1,PPP2R5B,SYVN1,SERP1,DNAJB9,LMNA,YIF1A,TPP1,SEC31A,SHC1,WIPI1,WFS1,XBP1,ASNA1,FKBP14,ATP6V0D1,KLHDC3,DCTN1,PREB
R-HSA-69186	Lagging Strand Synthesis	0.000227415293436851	-8.38873272544904	21	14	0.00615114235500879	2276	8202	23649,6118,5984,5111,5983,5422,3978,5981,10714,5982,57804,5424,2237,5425	POLA2,RPA2,RFC4,PCNA,RFC3,POLA1,LIG1,RFC1,POLD3,RFC2,POLD4,POLD1,FEN1,POLD2
R-HSA-975871	MyD88 cascade initiated on plasma membrane	0.000235485426654168	-8.35386152899514	82	38	0.0166959578207381	2276	8202	23291,3146,1848,257397,5604,4205,1147,9252,5606,3725,466,6196,5518,3551,5601,6885,4791,7314,5598,1386,5970,7311,8767,5609,7867,51295,7335,246330,2002,2353,7316,8517,6233,5608,10454,7334,5528,8945	FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,MAP2K3,JUN,ATF1,RPS6KA2,PPP2R1A,IKBKB,MAPK9,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,PELI3,ELK1,FOS,UBC,IKBKG,RPS27A,MAP2K6,TAB1,UBE2N,PPP2R5D,BTRC
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	0.000235485426654168	-8.35386152899514	82	38	0.0166959578207381	2276	8202	23291,3146,1848,257397,5604,4205,1147,9252,5606,3725,466,6196,5518,3551,5601,6885,4791,7314,5598,1386,5970,7311,8767,5609,7867,51295,7335,246330,2002,2353,7316,8517,6233,5608,10454,7334,5528,8945	FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,MAP2K3,JUN,ATF1,RPS6KA2,PPP2R1A,IKBKB,MAPK9,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,PELI3,ELK1,FOS,UBC,IKBKG,RPS27A,MAP2K6,TAB1,UBE2N,PPP2R5D,BTRC
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	0.000235485426654168	-8.35386152899514	82	38	0.0166959578207381	2276	8202	23291,3146,1848,257397,5604,4205,1147,9252,5606,3725,466,6196,5518,3551,5601,6885,4791,7314,5598,1386,5970,7311,8767,5609,7867,51295,7335,246330,2002,2353,7316,8517,6233,5608,10454,7334,5528,8945	FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,MAP2K3,JUN,ATF1,RPS6KA2,PPP2R1A,IKBKB,MAPK9,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,PELI3,ELK1,FOS,UBC,IKBKG,RPS27A,MAP2K6,TAB1,UBE2N,PPP2R5D,BTRC
R-HSA-73933	Resolution of Abasic Sites (AP sites)	0.000239388517406566	-8.33742273004014	35	20	0.00878734622144113	2276	8202	5984,5423,5983,4913,10038,3978,11284,10714,5982,5424,7515,6118,79661,6996,5111,5981,57804,4595,2237,5425	RFC4,POLB,RFC3,NTHL1,PARP2,LIG1,PNKP,POLD3,RFC2,POLD1,XRCC1,RPA2,NEIL1,TDG,PCNA,RFC1,POLD4,MUTYH,FEN1,POLD2
R-HSA-73884	Base Excision Repair	0.000239388517406566	-8.33742273004014	35	20	0.00878734622144113	2276	8202	5984,5423,5983,4913,10038,3978,11284,10714,5982,5424,7515,6118,79661,6996,5111,5981,57804,4595,2237,5425	RFC4,POLB,RFC3,NTHL1,PARP2,LIG1,PNKP,POLD3,RFC2,POLD1,XRCC1,RPA2,NEIL1,TDG,PCNA,RFC1,POLD4,MUTYH,FEN1,POLD2
R-HSA-201681	TCF dependent signaling in response to WNT	0.000246611256386541	-8.30769732193946	229	88	0.0386643233743409	2276	8202	3015,324,8350,1460,5526,2535,8658,8365,5707,5696,5687,1499,5518,57680,8364,9070,59349,3017,1856,8331,8321,7311,723790,208,1454,85236,5695,23401,3021,857,8340,80319,5529,8362,7514,8607,5719,6233,5714,5709,3014,5527,2932,5690,5705,9861,128312,5700,5528,5689,5693,8367,5713,90780,1452,5929,5715,8347,9491,8360,4609,653604,4040,5717,7314,5686,5694,7091,1455,5692,7090,607,5702,9101,5682,8363,5710,8368,5691,6934,7316,22943,3012,10023,7534,10197,81847,8945	H2AFZ,APC,HIST1H3A,CSNK2B,PPP2R5B,FZD2,TNKS,HIST1H4H,PSMD1,PSMB8,PSMA6,CTNNB1,PPP2R1A,CHD8,HIST1H4C,ASH2L,KLHL12,HIST1H2BD,DVL2,HIST1H2AJ,FZD1,UBA52,HIST2H2AA4,AKT2,CSNK1E,HIST1H2BK,PSMB7,FRAT2,H3F3B,CAV1,HIST1H2BL,CXXC4,PPP2R5E,HIST1H4K,XPO1,RUVBL1,PSMD13,RPS27A,PSMD8,PSMD3,H2AFX,PPP2R5C,GSK3B,PSMB2,PSMC5,PSMD6,HIST3H2BB,PSMC1,PPP2R5D,PSMB1,PSMB5,HIST1H4E,PSMD7,PYGO2,CSNK1A1,RBBP5,PSMD9,HIST1H2BC,PSMF1,HIST1H4D,MYC,HIST2H3D,LRP6,PSMD11,UBB,PSMA5,PSMB6,TLE4,CSNK1G2,PSMB4,TLE3,BCL9,PSMC3,USP8,PSMA1,HIST1H4J,PSMD4,HIST1H4L,PSMB3,TCF7L2,UBC,DKK1,HIST1H2AE,FRAT1,YWHAZ,PSME3,RNF146,BTRC
R-HSA-71406	Pyruvate metabolism and Citric Acid (TCA) cycle	0.000248482813962712	-8.30013687392297	45	24	0.0105448154657293	2276	8202	79944,5160,5163,8802,54704,6391,4191,5166,2271,3939,57546,682,2739,4967,3029,1743,6392,5467,50,5164,1431,6566,3420,1738	L2HGDH,PDHA1,PDK1,SUCLG1,PDP1,SDHC,MDH2,PDK4,FH,LDHA,PDP2,BSG,GLO1,OGDH,HAGH,DLST,SDHD,PPARD,ACO2,PDK2,CS,SLC16A1,IDH3B,DLD
R-HSA-5653656	Vesicle-mediated transport	0.000249757383951828	-8.29502057549997	294	109	0.0478910369068541	2276	8202	51552,27243,5564,6517,5565,26984,25977,162,7531,9919,8027,8729,9117,2647,805,4218,57148,5537,51399,8907,1785,55770,10342,1315,10802,10484,8615,7311,23256,208,3312,9525,10971,5571,7163,90411,5861,25978,7532,10890,22818,10972,6233,1213,4253,7251,6814,2580,9847,27131,22820,6396,10808,7184,6272,9871,51534,4012,11267,7082,7164,9685,8766,7037,4641,9276,4074,811,966,9632,81876,10960,3320,7314,22870,10959,10113,6811,2512,23433,54885,375056,10525,1777,10282,1294,9179,6810,51652,26258,8301,7316,22872,51128,27095,11196,51422,2801,79720,60412,9554,7534,55291,7533,79090,9882,164,5878,23557	RAB14,CHMP2A,PRKAB1,SLC2A4,PRKAB2,SEC22A,NECAP1,AP1B1,YWHAE,SEC16A,STAM,GBF1,SEC22C,BLOC1S1,CALM2,RAB8A,RALGAPB,PPP6C,TRAPPC4,AP1M1,DNM2,EXOC2,TFG,COPB1,SEC24A,SEC23A,USO1,UBA52,SCFD1,AKT2,HSPA8,VPS4B,YWHAQ,PRKAG1,TPD52,MCFD2,RAB1A,CHMP2B,YWHAG,RAB10,COPZ1,TMED10,RPS27A,CLTC,CTAGE5,TSG101,STXBP3,GAK,C2CD5,SNX5,COPG1,SEC13,HSPH1,HSP90B1,SORT1,SEC24D,VTA1,LNPEP,SNF8,TJP1,TPD52L1,CLINT1,RAB11A,TFRC,MYO1C,COPB2,M6PR,CALR,CD59,SEC24C,RAB1B,LMAN2,HSP90AA1,UBB,PPP6R1,TMED2,PREB,STX5,FTL,RHOQ,TBC1D8B,MIA3,HYOU1,DNASE2,BET1,COL7A1,AP4M1,STX4,CHMP3,BLOC1S6,PICALM,UBC,SEC31A,SAR1B,TRAPPC3,SEC23IP,PRKAG2,GOLGA2,VPS37B,EXOC4,SEC22B,YWHAZ,PPP6R3,YWHAH,TRAPPC6A,TBC1D4,AP1G1,RAB5C,SNAPIN
R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.000253526006925914	-8.28004414877145	85	39	0.0171353251318102	2276	8202	23291,3146,1848,257397,5604,4205,1147,9252,5606,3725,466,6196,5518,3551,5601,6885,4791,7314,5598,1386,5970,7311,8767,5609,7867,51295,7335,246330,2002,2353,7316,8517,6233,5608,10454,5528,7334,170506,8945	FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,MAP2K3,JUN,ATF1,RPS6KA2,PPP2R1A,IKBKB,MAPK9,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,PELI3,ELK1,FOS,UBC,IKBKG,RPS27A,MAP2K6,TAB1,PPP2R5D,UBE2N,DHX36,BTRC
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.000253526006925914	-8.28004414877145	85	39	0.0171353251318102	2276	8202	23291,3146,1848,257397,5604,4205,1147,9252,5606,3725,466,6196,5518,3551,5601,6885,4791,7314,5598,1386,5970,7311,8767,5609,7867,51295,7335,246330,2002,2353,7316,8517,6233,5608,10454,5528,7334,170506,8945	FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,MAP2K3,JUN,ATF1,RPS6KA2,PPP2R1A,IKBKB,MAPK9,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,PELI3,ELK1,FOS,UBC,IKBKG,RPS27A,MAP2K6,TAB1,PPP2R5D,UBE2N,DHX36,BTRC
R-HSA-5610787	Hedgehog 'off' state	0.000255979784739932	-8.27041208246232	99	44	0.0193321616871705	2276	8202	5689,5693,54903,5713,26160,1452,5566,5715,9491,79809,5707,5687,5696,5717,7314,5686,5694,2735,7311,5692,5702,5695,5682,5710,5691,7316,5719,6233,5714,5709,7289,55764,57728,8481,2932,5690,9742,10197,9861,5705,5700,8945,8650,5573	PSMB1,PSMB5,MKS1,PSMD7,IFT172,CSNK1A1,PRKACA,PSMD9,PSMF1,TTC21B,PSMD1,PSMA6,PSMB8,PSMD11,UBB,PSMA5,PSMB6,GLI1,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,PSMD4,PSMB3,UBC,PSMD13,RPS27A,PSMD8,PSMD3,TULP3,IFT122,WDR19,OFD1,GSK3B,PSMB2,IFT140,PSME3,PSMD6,PSMC5,PSMC1,BTRC,NUMB,PRKAR1A
R-HSA-381042	PERK regulates gene expression	0.000259962506622848	-8.25497314264407	28	17	0.00746924428822496	2276	8202	23404,468,118460,3309,9451,467,5393,9709,167227,23016,440,11340,4802,8570,22926,54512,1649	EXOSC2,ATF4,EXOSC6,HSPA5,EIF2AK3,ATF3,EXOSC9,HERPUD1,DCP2,EXOSC7,ASNS,EXOSC8,NFYC,KHSRP,ATF6,EXOSC4,DDIT3
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	0.000260758356990164	-8.25191641477851	19	13	0.00571177504393673	2276	8202	6118,5984,5423,5111,5983,3978,5981,10714,5982,57804,5424,2237,5425	RPA2,RFC4,POLB,PCNA,RFC3,LIG1,RFC1,POLD3,RFC2,POLD4,POLD1,FEN1,POLD2
R-HSA-110320	Translesion Synthesis by POLH	0.000260758356990164	-8.25191641477851	19	13	0.00571177504393673	2276	8202	6118,5984,5111,5983,7311,6233,83932,5981,7314,5982,7316,55666,7415	RPA2,RFC4,PCNA,RFC3,UBA52,RPS27A,SPRTN,RFC1,UBB,RFC2,UBC,NPLOC4,VCP
R-HSA-2559583	Cellular Senescence	0.000269679147058944	-8.21827764983291	187	74	0.0325131810193322	2276	8202	3015,3397,7157,8350,7290,6015,5606,8365,54386,6196,890,65057,4001,8364,51343,26277,10393,1027,51434,1032,5970,3017,1021,8331,7311,723790,1019,85236,1871,23466,8550,3021,8340,8697,8362,6233,3014,128312,1870,4343,1030,23112,51433,8367,8347,8360,3725,57332,5601,653604,5598,7314,6774,7014,6667,5931,5609,7867,29882,8363,8368,2353,7316,3012,2114,996,3569,5608,3159,4217,11065,1029,192669,1911	H2AFZ,ID1,TP53,HIST1H3A,HIRA,RING1,MAP2K3,HIST1H4H,TERF2IP,RPS6KA2,CCNA2,ACD,LMNB1,HIST1H4C,FZR1,TINF2,ANAPC10,CDKN1B,ANAPC7,CDKN2D,RELA,HIST1H2BD,CDK6,HIST1H2AJ,UBA52,HIST2H2AA4,CDK4,HIST1H2BK,E2F3,CBX6,MAPKAPK5,H3F3B,HIST1H2BL,CDC23,HIST1H4K,RPS27A,H2AFX,HIST3H2BB,E2F2,MOV10,CDKN2B,TNRC6B,ANAPC5,HIST1H4E,HIST1H2BC,HIST1H4D,JUN,CBX8,MAPK9,HIST2H3D,MAPK7,UBB,STAT3,TERF2,SP1,RBBP7,MAP2K7,MAPKAPK3,ANAPC2,HIST1H4J,HIST1H4L,FOS,UBC,HIST1H2AE,ETS2,CDC27,IL6,MAP2K6,HMGA1,MAP3K5,UBE2C,CDKN2A,AGO3,PHC1
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.000280630226905099	-8.17847267369877	105	46	0.0202108963093146	2276	8202	1030,51433,3015,8367,8350,8347,8360,8365,3725,6196,890,8364,51343,10393,1027,653604,51434,7314,5598,1032,5970,6774,3017,1021,8331,7311,723790,1019,85236,29882,3021,8340,8363,8697,8368,2353,7316,3012,8362,996,6233,3569,3014,128312,11065,1029	CDKN2B,ANAPC5,H2AFZ,HIST1H4E,HIST1H3A,HIST1H2BC,HIST1H4D,HIST1H4H,JUN,RPS6KA2,CCNA2,HIST1H4C,FZR1,ANAPC10,CDKN1B,HIST2H3D,ANAPC7,UBB,MAPK7,CDKN2D,RELA,STAT3,HIST1H2BD,CDK6,HIST1H2AJ,UBA52,HIST2H2AA4,CDK4,HIST1H2BK,ANAPC2,H3F3B,HIST1H2BL,HIST1H4J,CDC23,HIST1H4L,FOS,UBC,HIST1H2AE,HIST1H4K,CDC27,RPS27A,IL6,H2AFX,HIST3H2BB,UBE2C,CDKN2A
R-HSA-381038	XBP1(S) activates chaperone genes	0.000281570867723665	-8.17512639171783	53	27	0.0118629173989455	2276	8202	7709,9820,6734,2931,7094,64061,23480,7095,10525,5526,84447,27230,4189,4000,10897,1200,22872,6464,55062,7466,7494,439,55033,9114,116138,1639,10113	ZBTB17,CUL7,SRPR,GSK3A,TLN1,TSPYL2,SEC61G,SEC62,HYOU1,PPP2R5B,SYVN1,SERP1,DNAJB9,LMNA,YIF1A,TPP1,SEC31A,SHC1,WIPI1,WFS1,XBP1,ASNA1,FKBP14,ATP6V0D1,KLHDC3,DCTN1,PREB
R-HSA-5656121	Translesion synthesis by POLI	0.000291568771543601	-8.14023465703656	17	12	0.00527240773286467	2276	8202	6118,5984,5980,5111,5983,7311,6233,11201,5981,7314,5982,7316	RPA2,RFC4,REV3L,PCNA,RFC3,UBA52,RPS27A,POLI,RFC1,UBB,RFC2,UBC
R-HSA-68689	CDC6 association with the ORC:origin complex	0.000299485914248111	-8.11344317240587	11	9	0.00395430579964851	2276	8202	4999,5000,5001,84515,1871,990,4998,23595,1870	ORC2,ORC4,ORC5,MCM8,E2F3,CDC6,ORC1,ORC3,E2F2
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	0.000299564337601894	-8.11318134677776	33	19	0.00834797891036907	2276	8202	23511,8480,53371,10482,7884,9631,8021,23165,129401,5903,4686,4927,10189,55746,23636,9972,1977,9818,8086	NUP188,RAE1,NUP54,NXF1,SLBP,NUP155,NUP214,NUP205,NUP35,RANBP2,NCBP1,NUP88,ALYREF,NUP133,NUP62,NUP153,EIF4E,NUP58,AAAS
R-HSA-72187	mRNA 3'-end processing	0.000299564337601894	-8.11318134677776	33	19	0.00834797891036907	2276	8202	11338,6431,10250,9939,10978,10921,51585,6430,6426,11051,4686,10189,7307,6429,1478,6428,51692,9785,1477	U2AF2,SRSF6,SRRM1,RBM8A,CLP1,RNPS1,PCF11,SRSF5,SRSF1,NUDT21,NCBP1,ALYREF,U2AF1,SRSF4,CSTF2,SRSF3,CPSF3,DHX38,CSTF1
R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	0.000314443951962213	-8.06470471086235	15	11	0.00483304042179262	2276	8202	23658,196513,27258,23644,55802,25804,54464,27257,219988,167227,80153	LSM5,DCP1B,LSM3,EDC4,DCP1A,LSM4,XRN1,LSM1,PATL1,DCP2,EDC3
R-HSA-5358508	Mismatch Repair	0.000314443951962213	-8.06470471086235	15	11	0.00483304042179262	2276	8202	6118,9156,5111,4436,3978,4292,10714,57804,5424,5425,2956	RPA2,EXO1,PCNA,MSH2,LIG1,MLH1,POLD3,POLD4,POLD1,POLD2,MSH6
R-HSA-5696394	DNA Damage Recognition in GG-NER	0.000316150469648088	-8.05929228793778	38	21	0.00922671353251318	2276	8202	1643,7311,9318,54617,10038,7316,5886,1069,50813,51138,8607,6233,8533,10987,5887,29844,79913,125476,7314,86,1642	DDB2,UBA52,COPS2,INO80,PARP2,UBC,RAD23A,CETN2,COPS7A,COPS4,RUVBL1,RPS27A,COPS3,COPS5,RAD23B,TFPT,ACTR5,INO80C,UBB,ACTL6A,DDB1
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.0003196503979578	-8.04828266577249	83	38	0.0166959578207381	2276	8202	23291,3146,1848,257397,5604,4205,1147,9252,5606,3725,466,6196,5518,3551,5601,6885,4791,7314,5598,1386,5970,7311,8767,5609,7867,51295,7335,246330,2002,2353,7316,8517,6233,5608,10454,7334,5528,8945	FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,MAP2K3,JUN,ATF1,RPS6KA2,PPP2R1A,IKBKB,MAPK9,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,PELI3,ELK1,FOS,UBC,IKBKG,RPS27A,MAP2K6,TAB1,UBE2N,PPP2R5D,BTRC
R-HSA-5621481	C-type lectin receptors (CLRs)	0.000340509930889586	-7.98506626719183	123	52	0.0228471001757469	2276	8202	23291,5689,5693,257397,5894,5713,1147,5566,9252,5715,9491,805,5707,5696,5687,3551,5971,5717,6885,4791,7314,10768,5970,5686,5694,5058,5170,7311,5692,5702,5695,10892,5682,3845,7335,5710,5691,7316,8517,5719,6233,5714,5709,7322,5690,5705,9861,10197,10454,5700,7334,8945	FBXW11,PSMB1,PSMB5,TAB3,RAF1,PSMD7,CHUK,PRKACA,RPS6KA5,PSMD9,PSMF1,CALM2,PSMD1,PSMB8,PSMA6,IKBKB,RELB,PSMD11,MAP3K7,NFKB2,UBB,AHCYL1,RELA,PSMA5,PSMB6,PAK1,PDPK1,UBA52,PSMB4,PSMC3,PSMB7,MALT1,PSMA1,KRAS,UBE2V1,PSMD4,PSMB3,UBC,IKBKG,PSMD13,RPS27A,PSMD8,PSMD3,UBE2D2,PSMB2,PSMC5,PSMD6,PSME3,TAB1,PSMC1,UBE2N,BTRC
R-HSA-5357905	Regulation of TNFR1 signaling	0.000374254613801024	-7.89057420661488	31	18	0.00790861159929701	2276	8202	7375,1540,7311,7128,330,7186,8887,1147,10399,27005,329,7316,8517,6233,55072,3551,7314,90268	USP4,CYLD,UBA52,TNFAIP3,BIRC3,TRAF2,TAX1BP1,CHUK,GNB2L1,USP21,BIRC2,UBC,IKBKG,RPS27A,RNF31,IKBKB,UBB,OTULIN
R-HSA-73893	DNA Damage Bypass	0.000384076679873575	-7.86466833814061	46	24	0.0105448154657293	2276	8202	5984,5983,7311,83932,10714,5982,5424,7316,7415,55666,6118,5980,5111,9768,56852,6233,11201,7320,7398,5981,7314,57804,5425,1642	RFC4,RFC3,UBA52,SPRTN,POLD3,RFC2,POLD1,UBC,VCP,NPLOC4,RPA2,REV3L,PCNA,KIAA0101,RAD18,RPS27A,POLI,UBE2B,USP1,RFC1,UBB,POLD4,POLD2,DDB1
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	0.000399080899401303	-7.82634640623477	36	20	0.00878734622144113	2276	8202	23511,8480,53371,10482,7884,9631,8021,23165,129401,5903,4686,4927,10189,55746,23636,9972,51692,1977,9818,8086	NUP188,RAE1,NUP54,NXF1,SLBP,NUP155,NUP214,NUP205,NUP35,RANBP2,NCBP1,NUP88,ALYREF,NUP133,NUP62,NUP153,CPSF3,EIF4E,NUP58,AAAS
R-HSA-69473	G2/M DNA damage checkpoint	0.000403300603033411	-7.81582836083834	70	33	0.0144991212653779	2276	8202	8367,29086,1111,7531,8347,8360,7341,8365,7465,8364,84126,545,3017,85236,10971,8340,8363,9025,8368,995,983,7532,8362,7158,7336,3014,51720,165918,7534,11200,128312,7533,7334	HIST1H4E,BABAM1,CHEK1,YWHAE,HIST1H2BC,HIST1H4D,SUMO1,HIST1H4H,WEE1,HIST1H4C,ATRIP,ATR,HIST1H2BD,HIST1H2BK,YWHAQ,HIST1H2BL,HIST1H4J,RNF8,HIST1H4L,CDC25C,CDK1,YWHAG,HIST1H4K,TP53BP1,UBE2V2,H2AFX,UIMC1,RNF168,YWHAZ,CHEK2,HIST3H2BB,YWHAH,UBE2N
R-HSA-194315	Signaling by Rho GTPases	0.000413941278469572	-7.7897864336446	399	141	0.0619507908611599	2276	8202	23092,3015,8936,8350,11004,7531,81624,10144,4628,79003,8365,805,9183,1499,84986,998,5296,8379,2017,10097,147179,9754,8331,6453,1058,723790,4690,85236,3021,9212,8340,25936,3688,5527,128312,5528,64857,4659,9886,1495,1063,4983,3831,29127,8347,6242,9735,114793,9475,5058,10152,23433,8368,10552,116985,171177,4660,23221,7534,286205,10109,10163,4771,9322,10928,10096,4627,5526,54509,27237,23028,55845,55746,5518,8364,9928,30851,1027,4637,9828,3017,10006,1856,348235,57120,991,1894,1742,10971,6232,701,995,79682,7532,3796,5529,5903,7514,8362,79980,8976,4085,3014,5500,6722,23122,151648,6396,8367,11113,55143,57591,3633,55055,8360,79172,91687,5586,151246,9055,653604,9181,79019,10726,5170,10451,55789,11130,23365,8363,1729,9901,401541,3012,332,147841,1062,57082,7533,23229,23081	ARHGAP26,H2AFZ,WASF1,HIST1H3A,KIF2C,YWHAE,DIAPH3,FAM13A,MYH10,MIS12,HIST1H4H,CALM2,ZW10,CTNNB1,ARHGAP19,CDC42,PIK3R2,MAD1L1,CTTN,ACTR2,WIPF2,STARD8,HIST1H2AJ,ITSN1,CENPA,HIST2H2AA4,NCK1,HIST1H2BK,H3F3B,AURKB,HIST1H2BL,NSL1,ITGB1,PPP2R5C,HIST3H2BB,PPP2R5D,PLEKHG2,PPP1R12A,RHOBTB1,CTNNA1,CENPF,OPHN1,KLC1,RACGAP1,HIST1H2BC,RTKN,KNTC1,FMNL2,ROCK2,PAK1,ABI2,RHOQ,HIST1H4L,ARPC1A,ARAP1,RHOV,PPP1R12B,RHOBTB2,YWHAZ,SCAI,ARPC2,WASF2,NF2,TRIP10,RALBP1,ACTR3,MYH9,PPP2R5B,RHOF,ARHGEF16,KDM1A,BRK1,NUP133,PPP2R1A,HIST1H4C,KIF14,TAX1BP3,CDKN1B,MYL6,ARHGEF17,HIST1H2BD,ABI1,DVL2,SKA2,GOPC,CDC20,ECT2,DLG4,YWHAQ,RPS27,BUB1B,CDC25C,CENPU,YWHAG,KIF2A,PPP2R5E,RANBP2,XPO1,HIST1H4K,DSN1,WASL,MAD2L1,H2AFX,PPP1CB,SRF,CLASP2,SGOL1,SEC13,HIST1H4E,CIT,CDCA8,MKL1,INPP5B,ZWILCH,HIST1H4D,CENPO,CENPL,PKN2,SGOL2,PRC1,HIST2H3D,ARHGEF2,CENPM,NUDC,PDPK1,VAV3,DEPDC1B,ZWINT,ARHGEF12,HIST1H4J,DIAPH1,SRGAP3,CENPP,HIST1H2AE,BIRC5,SPC24,CENPE,CASC5,YWHAH,ARHGEF9,KDM4C
R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	0.000455820000391806	-7.69341256236153	49	25	0.0109841827768014	2276	8202	5689,5693,5692,5702,5695,5713,5682,5710,5715,9491,5691,5687,5696,5707,5719,5714,5709,5690,5717,5705,9861,10197,5700,5686,5694	PSMB1,PSMB5,PSMB4,PSMC3,PSMB7,PSMD7,PSMA1,PSMD4,PSMD9,PSMF1,PSMB3,PSMA6,PSMB8,PSMD1,PSMD13,PSMD8,PSMD3,PSMB2,PSMD11,PSMC5,PSMD6,PSME3,PSMC1,PSMA5,PSMB6
R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.000465368167385158	-7.67268170783425	65	31	0.0136203866432337	2276	8202	5883,5984,5983,7311,5810,11073,83990,144715,7156,1111,5884,641,10714,5982,5424,7316,6118,9156,5889,5111,675,6233,7516,84126,7517,545,5981,7314,348654,57804,5425	RAD9A,RFC4,RFC3,UBA52,RAD1,TOPBP1,BRIP1,RAD9B,TOP3A,CHEK1,RAD17,BLM,POLD3,RFC2,POLD1,UBC,RPA2,EXO1,RAD51C,PCNA,BRCA2,RPS27A,XRCC2,ATRIP,XRCC3,ATR,RFC1,UBB,GEN1,POLD4,POLD2
R-HSA-5205685	Pink/Parkin Mediated Mitophagy	0.000465978617435947	-7.67137081022198	22	14	0.00615114235500879	2276	8202	9868,55669,9804,7311,8878,6233,9140,56993,9474,10452,7314,7416,7316,401505	TOMM70A,MFN1,TOMM20,UBA52,SQSTM1,RPS27A,ATG12,TOMM22,ATG5,TOMM40,UBB,VDAC1,UBC,TOMM5
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	0.000465978617435947	-7.67137081022198	22	14	0.00615114235500879	2276	8202	6118,5984,5423,5111,5983,10038,3978,5981,10714,5982,57804,5424,2237,5425	RPA2,RFC4,POLB,PCNA,RFC3,PARP2,LIG1,RFC1,POLD3,RFC2,POLD4,POLD1,FEN1,POLD2
R-HSA-5205647	Mitophagy	0.000465978617435947	-7.67137081022198	22	14	0.00615114235500879	2276	8202	9868,55669,9804,7311,8878,6233,9140,56993,9474,10452,7314,7416,7316,401505	TOMM70A,MFN1,TOMM20,UBA52,SQSTM1,RPS27A,ATG12,TOMM22,ATG5,TOMM40,UBB,VDAC1,UBC,TOMM5
R-HSA-180786	Extension of Telomeres	0.000466618508608477	-7.66999853219307	29	17	0.00746924428822496	2276	8202	23649,5984,5983,5422,3978,55651,10714,5982,5424,6118,5111,8607,5981,57804,55135,2237,5425	POLA2,RFC4,RFC3,POLA1,LIG1,NHP2,POLD3,RFC2,POLD1,RPA2,PCNA,RUVBL1,RFC1,POLD4,WRAP53,FEN1,POLD2
R-HSA-5696395	Formation of Incision Complex in GG-NER	0.000488487367031405	-7.6241969475499	44	23	0.0101054481546573	2276	8202	1643,2067,7311,902,2071,10038,7329,7316,7341,5886,6118,1069,2968,7336,6233,5887,2965,54778,2073,2068,7314,7334,1642	DDB2,ERCC1,UBA52,CCNH,ERCC3,PARP2,UBE2I,UBC,SUMO1,RAD23A,RPA2,CETN2,GTF2H4,UBE2V2,RPS27A,RAD23B,GTF2H1,RNF111,ERCC5,ERCC2,UBB,UBE2N,DDB1
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	0.000510874800117397	-7.57938600733531	68	32	0.0140597539543058	2276	8202	23411,10808,23511,6767,8480,3309,3312,53371,57805,9631,3337,7531,91582,8021,51501,23165,129401,3304,6118,5903,3313,3308,4927,55746,10049,2932,23636,9972,545,6782,9818,8086	SIRT1,HSPH1,NUP188,ST13,RAE1,HSPA5,HSPA8,NUP54,CCAR2,NUP155,DNAJB1,YWHAE,RPS19BP1,NUP214,C11orf73,NUP205,NUP35,HSPA1B,RPA2,RANBP2,HSPA9,HSPA4,NUP88,NUP133,DNAJB6,GSK3B,NUP62,NUP153,ATR,HSPA13,NUP58,AAAS
R-HSA-1268020	Mitochondrial protein import	0.000529208920988862	-7.54412726836582	52	26	0.0114235500878735	2276	8202	516,9868,9804,26515,80273,29090,4580,506,10452,131118,7416,26519,134266,401505,26520,50,3313,25813,1678,10440,29928,1431,56993,498,1537,10651	ATP5G1,TOMM70A,TOMM20,TIMM10B,GRPEL1,TIMM21,MTX1,ATP5B,TOMM40,DNAJC19,VDAC1,TIMM10,GRPEL2,TOMM5,TIMM9,ACO2,HSPA9,SAMM50,TIMM8A,TIMM17A,TIMM22,CS,TOMM22,ATP5A1,CYC1,MTX2
R-HSA-6784531	tRNA processing in the nucleus	0.000603188436970221	-7.41328091093334	55	27	0.0118629173989455	2276	8202	51095,23511,8480,10978,53371,9631,10775,60528,51367,79074,51637,8021,11260,23165,129401,5903,4927,11102,339487,55746,10248,1478,23636,9972,283742,9818,8086	TRNT1,NUP188,RAE1,CLP1,NUP54,NUP155,POP4,ELAC2,POP5,C2orf49,C14orf166,NUP214,XPOT,NUP205,NUP35,RANBP2,NUP88,RPP14,ZBTB8OS,NUP133,POP7,CSTF2,NUP62,NUP153,FAM98B,NUP58,AAAS
R-HSA-159227	Transport of the SLBP independent Mature mRNA	0.000635007439236005	-7.36187384380791	32	18	0.00790861159929701	2276	8202	23511,8480,53371,10482,9631,8021,23165,129401,5903,4686,4927,10189,55746,9972,23636,1977,9818,8086	NUP188,RAE1,NUP54,NXF1,NUP155,NUP214,NUP205,NUP35,RANBP2,NCBP1,NUP88,ALYREF,NUP133,NUP153,NUP62,EIF4E,NUP58,AAAS
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	0.000643827057763358	-7.34808041176999	37	20	0.00878734622144113	2276	8202	5984,5983,7311,83932,10714,5982,5424,7316,55666,7415,6118,5980,5111,9768,6233,11201,5981,7314,57804,5425	RFC4,RFC3,UBA52,SPRTN,POLD3,RFC2,POLD1,UBC,NPLOC4,VCP,RPA2,REV3L,PCNA,KIAA0101,RPS27A,POLI,RFC1,UBB,POLD4,POLD2
R-HSA-937061	TRIF-mediated TLR3/TLR4 signaling	0.000681987669216752	-7.29049898061161	97	42	0.0184534270650264	2276	8202	7323,23291,3146,1848,257397,5604,4205,1147,9252,329,5606,3725,466,6196,5518,3551,5601,5781,6885,4791,7314,5598,1386,5970,7311,8767,5609,330,7867,7335,2002,2353,7316,8772,8517,6233,5608,7322,10454,5528,7334,8945	UBE2D3,FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,BIRC2,MAP2K3,JUN,ATF1,RPS6KA2,PPP2R1A,IKBKB,MAPK9,PTPN11,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,BIRC3,MAPKAPK3,UBE2V1,ELK1,FOS,UBC,FADD,IKBKG,RPS27A,MAP2K6,UBE2D2,TAB1,PPP2R5D,UBE2N,BTRC
R-HSA-166166	MyD88-independent TLR3/TLR4 cascade	0.000681987669216752	-7.29049898061161	97	42	0.0184534270650264	2276	8202	7323,23291,3146,1848,257397,5604,4205,1147,9252,329,5606,3725,466,6196,5518,3551,5601,5781,6885,4791,7314,5598,1386,5970,7311,8767,5609,330,7867,7335,2002,2353,7316,8772,8517,6233,5608,7322,10454,5528,7334,8945	UBE2D3,FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,BIRC2,MAP2K3,JUN,ATF1,RPS6KA2,PPP2R1A,IKBKB,MAPK9,PTPN11,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,BIRC3,MAPKAPK3,UBE2V1,ELK1,FOS,UBC,FADD,IKBKG,RPS27A,MAP2K6,UBE2D2,TAB1,PPP2R5D,UBE2N,BTRC
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	0.000681987669216752	-7.29049898061161	97	42	0.0184534270650264	2276	8202	7323,23291,3146,1848,257397,5604,4205,1147,9252,329,5606,3725,466,6196,5518,3551,5601,5781,6885,4791,7314,5598,1386,5970,7311,8767,5609,330,7867,7335,2002,2353,7316,8772,8517,6233,5608,7322,10454,5528,7334,8945	UBE2D3,FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,BIRC2,MAP2K3,JUN,ATF1,RPS6KA2,PPP2R1A,IKBKB,MAPK9,PTPN11,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,BIRC3,MAPKAPK3,UBE2V1,ELK1,FOS,UBC,FADD,IKBKG,RPS27A,MAP2K6,UBE2D2,TAB1,PPP2R5D,UBE2N,BTRC
R-HSA-380994	ATF4 activates genes	0.000719310298224094	-7.23721772418512	25	15	0.00659050966608084	2276	8202	23404,440,23016,468,118460,4802,11340,8570,22926,467,5393,54512,9709,1649,167227	EXOSC2,ASNS,EXOSC7,ATF4,EXOSC6,NFYC,EXOSC8,KHSRP,ATF6,ATF3,EXOSC9,EXOSC4,HERPUD1,DDIT3,DCP2
R-HSA-110312	Translesion synthesis by REV1	0.000753637661237558	-7.19059886084792	16	11	0.00483304042179262	2276	8202	6118,5984,5980,5111,5983,7311,6233,5981,7314,5982,7316	RPA2,RFC4,REV3L,PCNA,RFC3,UBA52,RPS27A,RFC1,UBB,RFC2,UBC
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	0.000817238621003031	-7.10957943597719	35	19	0.00834797891036907	2276	8202	23511,8480,53371,10482,9631,8021,23165,129401,5903,4686,4927,10189,55746,23636,9972,51692,1977,9818,8086	NUP188,RAE1,NUP54,NXF1,NUP155,NUP214,NUP205,NUP35,RANBP2,NCBP1,NUP88,ALYREF,NUP133,NUP62,NUP153,CPSF3,EIF4E,NUP58,AAAS
R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	0.000843375828664762	-7.07809787645928	14	10	0.00439367311072056	2276	8202	6118,9156,5111,4436,3978,4292,10714,57804,5424,5425	RPA2,EXO1,PCNA,MSH2,LIG1,MLH1,POLD3,POLD4,POLD1,POLD2
R-HSA-73887	Death Receptor Signalling	0.00085866047430819	-7.06013697103175	48	24	0.0105448154657293	2276	8202	6868,7375,1540,7311,7128,330,257397,7186,8887,1147,10399,27005,329,7316,8772,55512,8517,6233,55072,3551,6885,7314,10454,90268	ADAM17,USP4,CYLD,UBA52,TNFAIP3,BIRC3,TAB3,TRAF2,TAX1BP1,CHUK,GNB2L1,USP21,BIRC2,UBC,FADD,SMPD3,IKBKG,RPS27A,RNF31,IKBKB,MAP3K7,UBB,TAB1,OTULIN
R-HSA-5357801	Programmed Cell Death	0.000865660522586902	-7.05201773250706	163	64	0.0281195079086116	2276	8202	8655,7157,324,598,7531,329,5707,5687,5696,1499,4001,5366,7311,330,208,842,5695,10971,1832,7532,572,5719,6233,5714,5709,5690,9861,5705,5700,4836,5689,3146,90427,5693,7186,5713,54205,7082,22985,5715,9491,4000,581,5717,7314,5686,3837,6709,5694,5692,5702,56616,5682,5339,5710,1613,8772,7316,5691,840,7534,3148,10197,7533	DYNLL1,TP53,APC,BCL2L1,YWHAE,BIRC2,PSMD1,PSMA6,PSMB8,CTNNB1,LMNB1,PMAIP1,UBA52,BIRC3,AKT2,CASP9,PSMB7,YWHAQ,DSP,YWHAG,BAD,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,NMT1,PSMB1,HMGB1,BMF,PSMB5,TRAF2,PSMD7,CYCS,TJP1,ACIN1,PSMD9,PSMF1,LMNA,BAX,PSMD11,UBB,PSMA5,KPNB1,SPTAN1,PSMB6,PSMB4,PSMC3,DIABLO,PSMA1,PLEC,PSMD4,DAPK3,FADD,UBC,PSMB3,CASP7,YWHAZ,HMGB2,PSME3,YWHAH
R-HSA-109581	Apoptosis	0.000868876527274422	-7.04830952878436	160	63	0.0276801405975395	2276	8202	4836,3146,5689,5693,90427,7186,8655,7157,5713,324,7082,54205,598,22985,7531,5715,9491,329,4000,5707,5687,5696,1499,4001,5366,581,5717,7314,3837,5686,5694,6709,7311,5692,208,5702,842,5695,5682,56616,10971,5339,5710,1832,5691,7532,7316,8772,1613,572,840,5719,6233,5714,5709,5690,3148,7534,9861,10197,5705,7533,5700	NMT1,HMGB1,PSMB1,PSMB5,BMF,TRAF2,DYNLL1,TP53,PSMD7,APC,TJP1,CYCS,BCL2L1,ACIN1,YWHAE,PSMD9,PSMF1,BIRC2,LMNA,PSMD1,PSMA6,PSMB8,CTNNB1,LMNB1,PMAIP1,BAX,PSMD11,UBB,KPNB1,PSMA5,PSMB6,SPTAN1,UBA52,PSMB4,AKT2,PSMC3,CASP9,PSMB7,PSMA1,DIABLO,YWHAQ,PLEC,PSMD4,DSP,PSMB3,YWHAG,UBC,FADD,DAPK3,BAD,CASP7,PSMD13,RPS27A,PSMD8,PSMD3,PSMB2,HMGB2,YWHAZ,PSMD6,PSME3,PSMC5,YWHAH,PSMC1
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	0.000887874712687161	-7.0266799142424	23	14	0.00615114235500879	2276	8202	51433,7311,996,6233,991,4085,10393,29882,701,51434,8697,7314,11065,7316	ANAPC5,UBA52,CDC27,RPS27A,CDC20,MAD2L1,ANAPC10,ANAPC2,BUB1B,ANAPC7,CDC23,UBB,UBE2C,UBC
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	0.000887874712687161	-7.0266799142424	23	14	0.00615114235500879	2276	8202	23649,6118,5984,5111,5983,5422,3978,5981,10714,5982,57804,5424,2237,5425	POLA2,RPA2,RFC4,PCNA,RFC3,POLA1,LIG1,RFC1,POLD3,RFC2,POLD4,POLD1,FEN1,POLD2
R-HSA-381183	ATF6-alpha activates chaperone genes	0.000892551883023073	-7.02142591376136	10	8	0.00351493848857645	2276	8202	811,468,7184,3309,7494,4802,22926,1649	CALR,ATF4,HSP90B1,HSPA5,XBP1,NFYC,ATF6,DDIT3
R-HSA-113507	E2F-enabled inhibition of pre-replication complex formation	0.000892551883023073	-7.02142591376136	10	8	0.00351493848857645	2276	8202	993,4999,4998,5000,23595,983,5001,84515	CDC25A,ORC2,ORC1,ORC4,ORC3,CDK1,ORC5,MCM8
R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	0.000901602456368582	-7.01133687078747	12	9	0.00395430579964851	2276	8202	7465,10971,7534,1111,7531,7533,995,983,7532	WEE1,YWHAQ,YWHAZ,CHEK1,YWHAE,YWHAH,CDC25C,CDK1,YWHAG
R-HSA-351202	Metabolism of polyamines	0.000945955666544881	-6.96331485412801	84	37	0.0162565905096661	2276	8202	384,5689,5693,1728,84245,5713,51686,5715,9491,4507,5707,5687,5696,51582,2805,5717,5686,5694,6611,58478,1373,5692,262,5702,6303,5695,5682,5710,5691,5719,5709,5714,5690,5705,10197,9861,5700	ARG2,PSMB1,PSMB5,NQO1,MRI1,PSMD7,OAZ3,PSMD9,PSMF1,MTAP,PSMD1,PSMA6,PSMB8,AZIN1,GOT1,PSMD11,PSMA5,PSMB6,SMS,ENOPH1,CPS1,PSMB4,AMD1,PSMC3,SAT1,PSMB7,PSMA1,PSMD4,PSMB3,PSMD13,PSMD3,PSMD8,PSMB2,PSMC5,PSME3,PSMD6,PSMC1
R-HSA-2559580	Oxidative Stress Induced Senescence	0.00101370909404264	-6.89413930447811	119	49	0.0215289982425308	2276	8202	1030,23112,3015,8367,7157,8350,8347,8360,6015,5606,8365,3725,57332,8364,5601,653604,7314,1032,3017,1021,8331,7311,5931,723790,5609,7867,1019,85236,23466,8550,1871,3021,8340,8363,8368,2353,7316,3012,8362,6233,5608,3014,4217,128312,1870,4343,192669,1029,1911	CDKN2B,TNRC6B,H2AFZ,HIST1H4E,TP53,HIST1H3A,HIST1H2BC,HIST1H4D,RING1,MAP2K3,HIST1H4H,JUN,CBX8,HIST1H4C,MAPK9,HIST2H3D,UBB,CDKN2D,HIST1H2BD,CDK6,HIST1H2AJ,UBA52,RBBP7,HIST2H2AA4,MAP2K7,MAPKAPK3,CDK4,HIST1H2BK,CBX6,MAPKAPK5,E2F3,H3F3B,HIST1H2BL,HIST1H4J,HIST1H4L,FOS,UBC,HIST1H2AE,HIST1H4K,RPS27A,MAP2K6,H2AFX,MAP3K5,HIST3H2BB,E2F2,MOV10,AGO3,CDKN2A,PHC1
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	0.00103753916118501	-6.87090356085128	33	18	0.00790861159929701	2276	8202	23511,140609,8480,53371,9631,8021,983,23165,129401,5903,4927,55746,91754,23636,9972,9133,9818,8086	NUP188,NEK7,RAE1,NUP54,NUP155,NUP214,CDK1,NUP205,NUP35,RANBP2,NUP88,NUP133,NEK9,NUP62,NUP153,CCNB2,NUP58,AAAS
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	0.00108984859159549	-6.82171649918265	21	13	0.00571177504393673	2276	8202	51433,7311,996,6233,991,10393,29882,51434,8697,7314,11065,983,7316	ANAPC5,UBA52,CDC27,RPS27A,CDC20,ANAPC10,ANAPC2,ANAPC7,CDC23,UBB,UBE2C,CDK1,UBC
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	0.00109442766641263	-6.81752373143322	54	26	0.0114235500878735	2276	8202	10802,10484,51141,9871,4597,10654,9453,1595,51128,3157,3422,3638,6721,4520,22937,9632,2224,4802,6907,57678,1717,6309,3837,2222,3156,6667	SEC24A,SEC23A,INSIG2,SEC24D,MVD,PMVK,GGPS1,CYP51A1,SAR1B,HMGCS1,IDI1,INSIG1,SREBF2,MTF1,SCAP,SEC24C,FDPS,NFYC,TBL1X,GPAM,DHCR7,SC5D,KPNB1,FDFT1,HMGCR,SP1
R-HSA-168325	Viral Messenger RNA Synthesis	0.00120234282697646	-6.72348326974411	41	21	0.00922671353251318	2276	8202	23511,5440,8480,53371,9631,8021,23165,5430,129401,2962,5432,5903,4927,55746,5434,2963,23636,9972,9818,5431,8086	NUP188,POLR2K,RAE1,NUP54,NUP155,NUP214,NUP205,POLR2A,NUP35,GTF2F1,POLR2C,RANBP2,NUP88,NUP133,POLR2E,GTF2F2,NUP62,NUP153,NUP58,POLR2B,AAAS
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	0.00126663480516757	-6.67139165504935	26	15	0.00659050966608084	2276	8202	8517,7375,1540,7128,330,257397,7186,55072,3551,1147,10399,6885,10454,27005,329	IKBKG,USP4,CYLD,TNFAIP3,BIRC3,TAB3,TRAF2,RNF31,IKBKB,CHUK,GNB2L1,MAP3K7,TAB1,USP21,BIRC2
R-HSA-76066	RNA Polymerase III Transcription Initiation From Type 2 Promoter	0.00126663480516757	-6.67139165504935	26	15	0.00659050966608084	2276	8202	661,5440,9328,51082,6908,171568,55814,5434,9329,9330,55703,2972,51728,11128,10621	POLR3D,POLR2K,GTF3C5,POLR1D,TBP,POLR3H,BDP1,POLR2E,GTF3C4,GTF3C3,POLR3B,BRF1,POLR3K,POLR3A,POLR3F
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.00131742032278746	-6.63207975544015	31	17	0.00746924428822496	2276	8202	1455,23401,324,5526,857,2535,1452,5529,1499,5518,10023,4040,5527,2932,5528,1856,8321	CSNK1G2,FRAT2,APC,PPP2R5B,CAV1,FZD2,CSNK1A1,PPP2R5E,CTNNB1,PPP2R1A,FRAT1,LRP6,PPP2R5C,GSK3B,PPP2R5D,DVL2,FZD1
R-HSA-168638	NOD1/2 Signaling Pathway	0.00131742032278746	-6.63207975544015	31	17	0.00746924428822496	2276	8202	8517,1540,7128,330,8767,257397,5608,842,3551,835,1147,7335,6885,10454,329,7334,837	IKBKG,CYLD,TNFAIP3,BIRC3,RIPK2,TAB3,MAP2K6,CASP9,IKBKB,CASP2,CHUK,UBE2V1,MAP3K7,TAB1,BIRC2,UBE2N,CASP4
R-HSA-3214815	HDACs deacetylate histones	0.00135904648331965	-6.60097194033652	94	40	0.0175746924428823	2276	8202	8367,8350,85235,8969,8347,317772,8360,23028,440689,8365,8329,54815,8364,653604,8332,3017,5926,8331,8819,57459,8336,5931,723790,9219,85236,23186,10362,8340,8363,8368,53615,25855,8330,3012,8362,2874,10284,6907,128312,3066	HIST1H4E,HIST1H3A,HIST1H2AH,HIST1H2AG,HIST1H2BC,HIST2H2AB,HIST1H4D,KDM1A,HIST2H2BF,HIST1H4H,HIST1H2AI,GATAD2A,HIST1H4C,HIST2H3D,HIST1H2AL,HIST1H2BD,ARID4A,HIST1H2AJ,SAP30,GATAD2B,HIST1H2AM,RBBP7,HIST2H2AA4,MTA2,HIST1H2BK,RCOR1,HMG20B,HIST1H2BL,HIST1H4J,HIST1H4L,MBD3,BRMS1,HIST1H2AK,HIST1H2AE,HIST1H4K,GPS2,SAP18,TBL1X,HIST3H2BB,HDAC2
R-HSA-202403	TCR signaling	0.00153299125862877	-6.48053438124259	115	47	0.0206502636203866	2276	8202	3122,23291,5689,5693,5713,1147,5715,9491,7408,5707,5687,5696,3551,5296,5717,6885,7314,5970,5686,5694,5170,5058,7311,5692,8767,4690,5702,5695,10892,5682,7335,5710,5691,7316,8517,5719,6233,5714,5709,7322,5690,5705,9861,10197,5700,7334,8945	HLA-DRA,FBXW11,PSMB1,PSMB5,PSMD7,CHUK,PSMD9,PSMF1,VASP,PSMD1,PSMA6,PSMB8,IKBKB,PIK3R2,PSMD11,MAP3K7,UBB,RELA,PSMA5,PSMB6,PDPK1,PAK1,UBA52,PSMB4,RIPK2,NCK1,PSMC3,PSMB7,MALT1,PSMA1,UBE2V1,PSMD4,PSMB3,UBC,IKBKG,PSMD13,RPS27A,PSMD8,PSMD3,UBE2D2,PSMB2,PSMC5,PSMD6,PSME3,PSMC1,UBE2N,BTRC
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.00158987081855092	-6.44410251224503	24	14	0.00615114235500879	2276	8202	5170,572,2931,2475,3164,208,842,1027,2932,253260,1147,84335,6199,64223	PDPK1,BAD,GSK3A,MTOR,NR4A1,AKT2,CASP9,CDKN1B,GSK3B,RICTOR,CHUK,AKT1S1,RPS6KB2,MLST8
R-HSA-5655862	Translesion synthesis by POLK	0.00160076395905604	-6.43727428928101	17	11	0.00483304042179262	2276	8202	6118,5984,5980,5111,5983,7311,6233,5981,7314,5982,7316	RPA2,RFC4,REV3L,PCNA,RFC3,UBA52,RPS27A,RFC1,UBB,RFC2,UBC
R-HSA-196299	Beta-catenin phosphorylation cascade	0.00160076395905604	-6.43727428928101	17	11	0.00483304042179262	2276	8202	5529,1499,5518,10023,2932,5527,23401,324,5526,1452,5528	PPP2R5E,CTNNB1,PPP2R1A,FRAT1,GSK3B,PPP2R5C,FRAT2,APC,PPP2R5B,CSNK1A1,PPP2R5D
R-HSA-936440	Negative regulators of RIG-I/MDA5 signaling	0.0016382785821859	-6.41410923341774	34	18	0.00790861159929701	2276	8202	55593,7323,1540,7311,7128,79671,8887,9140,51191,7316,6233,5300,7322,7314,9474,64135,5094,54476	OTUD5,UBE2D3,CYLD,UBA52,TNFAIP3,NLRX1,TAX1BP1,ATG12,HERC5,UBC,RPS27A,PIN1,UBE2D2,UBB,ATG5,IFIH1,PCBP2,RNF216
R-HSA-446205	Synthesis of GDP-mannose	0.00164014654033489	-6.41296968727511	5	5	0.00219683655536028	2276	8202	29925,5372,4351,5373,29926	GMPPB,PMM1,MPI,PMM2,GMPPA
R-HSA-597592	Post-translational protein modification	0.00165615572258684	-6.40325619206159	411	141	0.0619507908611599	2276	8202	23511,1801,5589,1798,11174,7329,9487,9919,1069,6484,4124,89978,9972,10342,23275,83475,8615,23137,25870,63917,26503,90411,84720,29926,10195,5372,4582,3703,10972,197370,57171,4253,165918,6483,55568,8704,8086,9871,1725,6480,79087,79053,128869,23165,129401,811,966,6184,56913,4927,57332,1938,1603,81876,54872,10960,5277,22870,285381,10959,6811,10113,1984,5279,51604,10274,11253,80267,5893,10282,84447,56160,59343,22872,27095,2677,6675,2801,9554,23636,493861,85365,55291,9818,1029,4351,26984,821,9117,6015,6996,55746,5537,51399,6185,23193,144245,10802,10484,23256,4597,9631,5861,8021,91869,79947,5903,1650,286053,8243,6400,440138,29925,6396,8480,10905,10825,10020,53371,56886,641,5373,5281,7341,9632,79868,10559,9761,10678,56648,375056,29071,1294,4758,51128,11196,84061,1802,199857,79090,1911	NUP188,DPH1,PRKCSH,DPAGT1,ADAMTS6,UBE2I,PIGL,SEC16A,CETN2,ST3GAL4,MAN2A1,DPH6,NUP153,TFG,POFUT2,DOHH,USO1,SMC5,SUMF2,GALNT11,SLC17A5,MCFD2,PIGO,GMPPA,ALG3,PMM1,MUC1,STT3A,TMED10,NSMCE1,DOLPP1,CTAGE5,RNF168,ST3GAL2,GALNT10,B4GALT2,AAAS,SEC24D,DHPS,ST6GAL1,ALG12,ALG8,PIGU,NUP205,NUP35,CALR,CD59,RPN1,C1GALT1,NUP88,CBX8,EEF2,DAD1,RAB1B,PIGG,LMAN2,PIGA,PPP6R1,DPH3,TMED2,STX5,PREB,EIF5A,PIGC,PIGT,STAG1,MAN1B1,EDEM3,RAD52,BET1,SYVN1,NDNL2,SENP2,SEC31A,TRAPPC3,GGCX,UAP1,GOLGA2,SEC22B,NUP62,EID3,ALG2,PPP6R3,NUP58,CDKN2A,MPI,SEC22A,CANX,SEC22C,RING1,TDG,NUP133,PPP6C,TRAPPC4,RPN2,GANAB,ALG10B,SEC24A,SEC23A,SCFD1,MVD,NUP155,RAB1A,NUP214,RFT1,DHDDS,RANBP2,DDOST,NSMCE2,SMC1A,SEL1L,ALG11,GMPPB,SEC13,RAE1,MAN1A2,NEU3,GNE,NUP54,UGGT1,BLM,PMM2,PIGF,SUMO1,SEC24C,ALG13,SLC35A1,MLEC,B3GNT2,EIF5A2,MIA3,C1GALT1C1,COL7A1,NEU1,SAR1B,SEC23IP,MAGT1,DPH2,ALG14,TRAPPC6A,PHC1
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	0.00168913220541759	-6.38354036984581	92	39	0.0171353251318102	2276	8202	23291,3146,1848,257397,5604,4205,1147,9252,5606,3725,466,6196,8651,5518,3551,5601,6885,4791,7314,5598,1386,5970,7311,8767,5609,7867,51295,7335,246330,2002,2353,7316,8517,6233,5608,10454,5528,7334,8945	FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,MAP2K3,JUN,ATF1,RPS6KA2,SOCS1,PPP2R1A,IKBKB,MAPK9,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,PELI3,ELK1,FOS,UBC,IKBKG,RPS27A,MAP2K6,TAB1,PPP2R5D,UBE2N,BTRC
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.00168913220541759	-6.38354036984581	92	39	0.0171353251318102	2276	8202	23291,3146,1848,257397,5604,4205,1147,9252,5606,3725,466,6196,8651,5518,3551,5601,6885,4791,7314,5598,1386,5970,7311,8767,5609,7867,51295,7335,246330,2002,2353,7316,8517,6233,5608,10454,5528,7334,8945	FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,MAP2K3,JUN,ATF1,RPS6KA2,SOCS1,PPP2R1A,IKBKB,MAPK9,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,PELI3,ELK1,FOS,UBC,IKBKG,RPS27A,MAP2K6,TAB1,PPP2R5D,UBE2N,BTRC
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.00168913220541759	-6.38354036984581	92	39	0.0171353251318102	2276	8202	23291,3146,1848,257397,5604,4205,1147,9252,5606,3725,466,6196,8651,5518,3551,5601,6885,4791,7314,5598,1386,5970,7311,8767,5609,7867,51295,7335,246330,2002,2353,7316,8517,6233,5608,10454,5528,7334,8945	FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,MAP2K3,JUN,ATF1,RPS6KA2,SOCS1,PPP2R1A,IKBKB,MAPK9,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,PELI3,ELK1,FOS,UBC,IKBKG,RPS27A,MAP2K6,TAB1,PPP2R5D,UBE2N,BTRC
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.00168913220541759	-6.38354036984581	92	39	0.0171353251318102	2276	8202	23291,3146,1848,257397,5604,4205,1147,9252,5606,3725,466,6196,8651,5518,3551,5601,6885,4791,7314,5598,1386,5970,7311,8767,5609,7867,51295,7335,246330,2002,2353,7316,8517,6233,5608,10454,5528,7334,8945	FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,MAP2K3,JUN,ATF1,RPS6KA2,SOCS1,PPP2R1A,IKBKB,MAPK9,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,PELI3,ELK1,FOS,UBC,IKBKG,RPS27A,MAP2K6,TAB1,PPP2R5D,UBE2N,BTRC
R-HSA-948021	Transport to the Golgi and subsequent modification	0.00172885599926746	-6.36029536130901	95	40	0.0175746924428823	2276	8202	6396,9871,6480,10905,26984,9919,9117,966,6484,9632,81876,5537,51399,4124,10960,10342,22870,10959,6811,10113,10802,10484,8615,23256,375056,10282,1294,5861,90411,22872,51128,27095,11196,2801,10972,4253,9554,55291,79090,8704	SEC13,SEC24D,ST6GAL1,MAN1A2,SEC22A,SEC16A,SEC22C,CD59,ST3GAL4,SEC24C,RAB1B,PPP6C,TRAPPC4,MAN2A1,LMAN2,TFG,PPP6R1,TMED2,STX5,PREB,SEC24A,SEC23A,USO1,SCFD1,MIA3,BET1,COL7A1,RAB1A,MCFD2,SEC31A,SAR1B,TRAPPC3,SEC23IP,GOLGA2,TMED10,CTAGE5,SEC22B,PPP6R3,TRAPPC6A,B4GALT2
R-HSA-3214858	RMTs methylate histone arginines	0.00178403551375274	-6.32887733821038	75	33	0.0144991212653779	2276	8202	8336,6595,3015,723790,5931,8367,1019,3276,8350,79084,85235,8363,55193,11091,8368,8969,317772,8360,8365,8329,8330,595,3012,8362,8364,3014,653604,3717,6603,8332,10419,86,8331	HIST1H2AM,SMARCA2,H2AFZ,HIST2H2AA4,RBBP7,HIST1H4E,CDK4,PRMT1,HIST1H3A,WDR77,HIST1H2AH,HIST1H4J,PBRM1,WDR5,HIST1H4L,HIST1H2AG,HIST2H2AB,HIST1H4D,HIST1H4H,HIST1H2AI,HIST1H2AK,CCND1,HIST1H2AE,HIST1H4K,HIST1H4C,H2AFX,HIST2H3D,JAK2,SMARCD2,HIST1H2AL,PRMT5,ACTL6A,HIST1H2AJ
R-HSA-76061	RNA Polymerase III Transcription Initiation From Type 1 Promoter	0.00212456284577054	-6.15418921740634	27	15	0.00659050966608084	2276	8202	661,5440,9328,51082,6908,171568,55814,5434,9329,9330,55703,2972,51728,11128,10621	POLR3D,POLR2K,GTF3C5,POLR1D,TBP,POLR3H,BDP1,POLR2E,GTF3C4,GTF3C3,POLR3B,BRF1,POLR3K,POLR3A,POLR3F
R-HSA-2995383	Initiation of Nuclear Envelope Reformation	0.00220795274169848	-6.11568955401261	13	9	0.00395430579964851	2276	8202	23141,2010,4001,5518,23592,7444,7443,4000,7112	ANKLE2,EMD,LMNB1,PPP2R1A,LEMD3,VRK2,VRK1,LMNA,TMPO
R-HSA-2995410	Nuclear Envelope Reassembly	0.00220795274169848	-6.11568955401261	13	9	0.00395430579964851	2276	8202	23141,2010,4001,5518,23592,7444,7443,4000,7112	ANKLE2,EMD,LMNB1,PPP2R1A,LEMD3,VRK2,VRK1,LMNA,TMPO
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	0.00258547300781069	-5.95784680601591	43	21	0.00922671353251318	2276	8202	9150,902,2071,5440,7936,6921,7469,6829,5430,2962,11198,5432,8178,4686,2968,5434,2963,2965,6917,2068,5431	CTDP1,CCNH,ERCC3,POLR2K,NELFE,TCEB1,NELFA,SUPT5H,POLR2A,GTF2F1,SUPT16H,POLR2C,ELL,NCBP1,GTF2H4,POLR2E,GTF2F2,GTF2H1,TCEA1,ERCC2,POLR2B
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	0.00258547300781069	-5.95784680601591	43	21	0.00922671353251318	2276	8202	9150,902,2071,5440,7936,6921,7469,6829,5430,2962,11198,5432,8178,4686,2968,5434,2963,2965,6917,2068,5431	CTDP1,CCNH,ERCC3,POLR2K,NELFE,TCEB1,NELFA,SUPT5H,POLR2A,GTF2F1,SUPT16H,POLR2C,ELL,NCBP1,GTF2H4,POLR2E,GTF2F2,GTF2H1,TCEA1,ERCC2,POLR2B
R-HSA-167169	HIV Transcription Elongation	0.00258547300781069	-5.95784680601591	43	21	0.00922671353251318	2276	8202	9150,902,2071,5440,7936,6921,7469,6829,5430,2962,11198,5432,8178,4686,2968,5434,2963,2965,6917,2068,5431	CTDP1,CCNH,ERCC3,POLR2K,NELFE,TCEB1,NELFA,SUPT5H,POLR2A,GTF2F1,SUPT16H,POLR2C,ELL,NCBP1,GTF2H4,POLR2E,GTF2F2,GTF2H1,TCEA1,ERCC2,POLR2B
R-HSA-5656169	Termination of translesion DNA synthesis	0.00267043097674836	-5.92551540508341	30	16	0.0070298769771529	2276	8202	5984,5983,7311,10714,5982,5424,7316,6118,9768,5111,6233,11201,5981,7314,57804,5425	RFC4,RFC3,UBA52,POLD3,RFC2,POLD1,UBC,RPA2,KIAA0101,PCNA,RPS27A,POLI,RFC1,UBB,POLD4,POLD2
R-HSA-5673000	RAF activation	0.00269785693540033	-5.91529754876992	25	14	0.00615114235500879	2276	8202	5529,673,369,5518,5894,5245,5604,4296,5527,3717,3845,5526,5528,4140	PPP2R5E,BRAF,ARAF,PPP2R1A,RAF1,PHB,MAP2K1,MAP3K11,PPP2R5C,JAK2,KRAS,PPP2R5B,PPP2R5D,MARK3
R-HSA-73864	RNA Polymerase I Transcription	0.00283157495856213	-5.86692219966807	109	44	0.0193321616871705	2276	8202	3015,5440,8367,6908,2071,25885,8350,7270,8347,8360,8365,54815,54700,284119,2968,8364,653604,2965,2068,3017,64425,8331,57459,902,5931,723790,9219,85236,3021,8340,8363,8368,53615,221830,11335,7343,3012,8362,2074,51082,5434,3014,128312,3066	H2AFZ,POLR2K,HIST1H4E,TBP,ERCC3,POLR1A,HIST1H3A,TTF1,HIST1H2BC,HIST1H4D,HIST1H4H,GATAD2A,RRN3,PTRF,GTF2H4,HIST1H4C,HIST2H3D,GTF2H1,ERCC2,HIST1H2BD,POLR1E,HIST1H2AJ,GATAD2B,CCNH,RBBP7,HIST2H2AA4,MTA2,HIST1H2BK,H3F3B,HIST1H2BL,HIST1H4J,HIST1H4L,MBD3,TWISTNB,CBX3,UBTF,HIST1H2AE,HIST1H4K,ERCC6,POLR1D,POLR2E,H2AFX,HIST3H2BB,HDAC2
R-HSA-166054	Activated TLR4 signalling	0.00284250377966716	-5.86307000264226	112	45	0.0197715289982425	2276	8202	7323,23291,3146,1848,257397,5604,4205,1147,9252,329,5606,3725,466,6196,8651,5518,3551,5601,5781,6885,4791,7314,5598,1386,5970,7311,8767,5609,330,7867,51295,7335,246330,2002,2353,7316,8772,8517,6233,5608,7322,10454,5528,7334,8945	UBE2D3,FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,BIRC2,MAP2K3,JUN,ATF1,RPS6KA2,SOCS1,PPP2R1A,IKBKB,MAPK9,PTPN11,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,BIRC3,MAPKAPK3,ECSIT,UBE2V1,PELI3,ELK1,FOS,UBC,FADD,IKBKG,RPS27A,MAP2K6,UBE2D2,TAB1,PPP2R5D,UBE2N,BTRC
R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	0.00291108708128423	-5.83922870010606	74	32	0.0140597539543058	2276	8202	23511,23137,10274,8480,53371,5893,9631,641,7329,8021,56160,23165,6015,129401,7341,1069,5903,4927,6996,57332,55746,197370,286053,8243,23636,493861,9972,165918,9818,1029,8086,1911	NUP188,SMC5,STAG1,RAE1,NUP54,RAD52,NUP155,BLM,UBE2I,NUP214,NDNL2,NUP205,RING1,NUP35,SUMO1,CETN2,RANBP2,NUP88,TDG,CBX8,NUP133,NSMCE1,NSMCE2,SMC1A,NUP62,EID3,NUP153,RNF168,NUP58,CDKN2A,AAAS,PHC1
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	0.00291108708128423	-5.83922870010606	74	32	0.0140597539543058	2276	8202	23511,23137,10274,8480,53371,5893,9631,641,7329,8021,56160,23165,6015,129401,7341,1069,5903,4927,6996,57332,55746,197370,286053,8243,23636,493861,9972,165918,9818,1029,8086,1911	NUP188,SMC5,STAG1,RAE1,NUP54,RAD52,NUP155,BLM,UBE2I,NUP214,NDNL2,NUP205,RING1,NUP35,SUMO1,CETN2,RANBP2,NUP88,TDG,CBX8,NUP133,NSMCE1,NSMCE2,SMC1A,NUP62,EID3,NUP153,RNF168,NUP58,CDKN2A,AAAS,PHC1
R-HSA-69236	G1 Phase	0.00291399523799814	-5.83823020539092	38	19	0.00834797891036907	2276	8202	1030,7311,902,1019,1875,1871,6502,7316,595,6233,5518,5933,1027,1163,7314,1032,1870,1021,1029	CDKN2B,UBA52,CCNH,CDK4,E2F5,E2F3,SKP2,UBC,CCND1,RPS27A,PPP2R1A,RBL1,CDKN1B,CKS1B,UBB,CDKN2D,E2F2,CDK6,CDKN2A
R-HSA-69231	Cyclin D associated events in G1	0.00291399523799814	-5.83823020539092	38	19	0.00834797891036907	2276	8202	1030,7311,902,1019,1875,1871,6502,7316,595,6233,5518,5933,1027,1163,7314,1032,1870,1021,1029	CDKN2B,UBA52,CCNH,CDK4,E2F5,E2F3,SKP2,UBC,CCND1,RPS27A,PPP2R1A,RBL1,CDKN1B,CKS1B,UBB,CDKN2D,E2F2,CDK6,CDKN2A
R-HSA-5620924	Intraflagellar transport	0.00330328251549186	-5.71283860323338	41	20	0.00878734622144113	2276	8202	64792,83658,112752,8655,26160,89891,9321,80173,11020,79809,23059,51668,83657,79989,90410,57728,55764,51626,55112,9742	IFT22,DYNLRB1,IFT43,DYNLL1,IFT172,WDR34,TRIP11,IFT74,IFT27,TTC21B,CLUAP1,HSPB11,DYNLRB2,TTC26,IFT20,WDR19,IFT122,DYNC2LI1,WDR60,IFT140
R-HSA-5620922	BBSome-mediated cargo-targeting to cilium	0.00342504932600458	-5.67663940561849	23	13	0.00571177504393673	2276	8202	84100,10576,6950,129880,585,92482,7203,79738,55212,27241,10694,166379,10575	ARL6,CCT2,TCP1,BBS5,BBS4,BBIP1,CCT3,BBS10,BBS7,BBS9,CCT8,BBS12,CCT4
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	0.00346732487767083	-5.66437191096678	107	43	0.0188927943760984	2276	8202	3015,5440,8367,6908,2071,25885,8350,25942,7270,23378,8347,8360,8365,79595,2968,8364,653604,2965,2068,3017,64425,8331,8819,23309,23411,902,723790,11176,85236,3021,8340,8363,8368,221830,7343,3012,8362,51082,5434,3014,10284,128312,3066	H2AFZ,POLR2K,HIST1H4E,TBP,ERCC3,POLR1A,HIST1H3A,SIN3A,TTF1,RRP8,HIST1H2BC,HIST1H4D,HIST1H4H,SAP130,GTF2H4,HIST1H4C,HIST2H3D,GTF2H1,ERCC2,HIST1H2BD,POLR1E,HIST1H2AJ,SAP30,SIN3B,SIRT1,CCNH,HIST2H2AA4,BAZ2A,HIST1H2BK,H3F3B,HIST1H2BL,HIST1H4J,HIST1H4L,TWISTNB,UBTF,HIST1H2AE,HIST1H4K,POLR1D,POLR2E,H2AFX,SAP18,HIST3H2BB,HDAC2
R-HSA-71291	Metabolism of amino acids and derivatives	0.00361731111182855	-5.62202431593494	212	77	0.0338312829525483	2276	8202	384,1728,58472,56922,51686,2639,4552,5707,5687,440,5696,6821,65263,2805,1738,152926,1491,2954,1081,6303,5695,56267,4967,1743,2744,5719,5714,8942,5709,5690,5705,9861,5700,5723,10295,5689,5693,4329,593,84245,1734,5713,5715,9491,4507,8659,883,1468,51582,501,5717,29920,5832,1629,64087,5686,6611,5694,58478,5625,6470,1373,5692,29968,594,2729,5702,262,5682,5710,144193,4548,5691,10197,55748,2653,11112	ARG2,NQO1,SQRDL,MCCC1,OAZ3,GCDH,MTRR,PSMD1,PSMA6,ASNS,PSMB8,SUOX,PYCRL,GOT1,DLD,PPM1K,CTH,GSTZ1,CGA,SAT1,PSMB7,CCBL2,OGDH,DLST,GLS,PSMD13,PSMD8,KYNU,PSMD3,PSMB2,PSMC5,PSMD6,PSMC1,PSPH,BCKDK,PSMB1,PSMB5,ALDH6A1,BCKDHA,MRI1,DIO2,PSMD7,PSMD9,PSMF1,MTAP,ALDH4A1,CCBL1,SLC25A10,AZIN1,ALDH7A1,PSMD11,PYCR2,ALDH18A1,DBT,MCCC2,PSMA5,SMS,PSMB6,ENOPH1,PRODH,SHMT1,CPS1,PSMB4,PSAT1,BCKDHB,GCLC,PSMC3,AMD1,PSMA1,PSMD4,AMDHD1,MTR,PSMB3,PSME3,CNDP2,GCSH,HIBADH
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	0.00367093767357755	-5.60730815266181	44	21	0.00922671353251318	2276	8202	9150,902,2071,5440,7936,6921,7469,6829,5430,2962,11198,5432,8178,4686,2968,5434,2963,2965,6917,2068,5431	CTDP1,CCNH,ERCC3,POLR2K,NELFE,TCEB1,NELFA,SUPT5H,POLR2A,GTF2F1,SUPT16H,POLR2C,ELL,NCBP1,GTF2H4,POLR2E,GTF2F2,GTF2H1,TCEA1,ERCC2,POLR2B
R-HSA-75955	RNA Polymerase II Transcription Elongation	0.00367093767357755	-5.60730815266181	44	21	0.00922671353251318	2276	8202	9150,902,7936,5440,2071,6921,7469,6829,5430,11198,2962,5432,8178,4686,2968,2963,5434,2965,2068,6917,5431	CTDP1,CCNH,NELFE,POLR2K,ERCC3,TCEB1,NELFA,SUPT5H,POLR2A,SUPT16H,GTF2F1,POLR2C,ELL,NCBP1,GTF2H4,GTF2F2,POLR2E,GTF2H1,ERCC2,TCEA1,POLR2B
R-HSA-112382	Formation of RNA Pol II elongation complex	0.00367093767357755	-5.60730815266181	44	21	0.00922671353251318	2276	8202	9150,902,7936,5440,2071,6921,7469,6829,5430,11198,2962,5432,8178,4686,2968,2963,5434,2965,2068,6917,5431	CTDP1,CCNH,NELFE,POLR2K,ERCC3,TCEB1,NELFA,SUPT5H,POLR2A,SUPT16H,GTF2F1,POLR2C,ELL,NCBP1,GTF2H4,GTF2F2,POLR2E,GTF2H1,ERCC2,TCEA1,POLR2B
R-HSA-5684264	MAP3K8 (TPL2)-dependent MAPK1/3 activation	0.00381390945014541	-5.56910051352638	16	10	0.00439367311072056	2276	8202	23291,8517,7311,6233,3551,5604,1147,7314,7316,8945	FBXW11,IKBKG,UBA52,RPS27A,IKBKB,MAP2K1,CHUK,UBB,UBC,BTRC
R-HSA-163210	Formation of ATP by chemiosmotic coupling	0.00381390945014541	-5.56910051352638	16	10	0.00439367311072056	2276	8202	516,10632,517,10476,521,506,498,514,9551,513	ATP5G1,ATP5L,ATP5G2,ATP5H,ATP5I,ATP5B,ATP5A1,ATP5E,ATP5J2,ATP5D
R-HSA-69183	Processive synthesis on the lagging strand	0.00381390945014541	-5.56910051352638	16	10	0.00439367311072056	2276	8202	23649,6118,5111,5422,3978,10714,57804,5424,2237,5425	POLA2,RPA2,PCNA,POLA1,LIG1,POLD3,POLD4,POLD1,FEN1,POLD2
R-HSA-5632684	Hedgehog 'on' state	0.00400335223787263	-5.52062320936985	84	35	0.015377855887522	2276	8202	5689,5693,5713,1452,5715,9491,2622,5707,5687,5696,5717,7314,5686,5694,2735,7311,5692,5702,5695,5682,5710,5691,7316,8405,5719,6233,5709,5714,5690,84455,10197,9861,5705,5700,8650	PSMB1,PSMB5,PSMD7,CSNK1A1,PSMD9,PSMF1,GAS8,PSMD1,PSMA6,PSMB8,PSMD11,UBB,PSMA5,PSMB6,GLI1,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,PSMD4,PSMB3,UBC,SPOP,PSMD13,RPS27A,PSMD3,PSMD8,PSMB2,EFCAB7,PSME3,PSMD6,PSMC5,PSMC1,NUMB
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	0.00401408071072235	-5.51794692150512	47	22	0.00966608084358524	2276	8202	1540,7128,330,8767,257397,3326,842,1147,7335,598,329,837,24145,8517,10910,5608,10628,3551,835,6885,10454,7334	CYLD,TNFAIP3,BIRC3,RIPK2,TAB3,HSP90AB1,CASP9,CHUK,UBE2V1,BCL2L1,BIRC2,CASP4,PANX1,IKBKG,SUGT1,MAP2K6,TXNIP,IKBKB,CASP2,MAP3K7,TAB1,UBE2N
R-HSA-5358351	Signaling by Hedgehog	0.00404180977958708	-5.51106272207123	135	52	0.0228471001757469	2276	8202	5689,5693,54903,5713,26160,1452,5566,5715,9491,2622,79809,5707,5687,5696,5034,5717,7314,5686,5694,2735,6868,7311,5692,5702,5695,5682,84447,5710,5691,7316,7415,8405,5719,6233,5714,5709,7289,55764,57728,8481,6400,9742,5690,2932,84455,9861,10197,5705,5700,8650,8945,5573	PSMB1,PSMB5,MKS1,PSMD7,IFT172,CSNK1A1,PRKACA,PSMD9,PSMF1,GAS8,TTC21B,PSMD1,PSMA6,PSMB8,P4HB,PSMD11,UBB,PSMA5,PSMB6,GLI1,ADAM17,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,SYVN1,PSMD4,PSMB3,UBC,VCP,SPOP,PSMD13,RPS27A,PSMD8,PSMD3,TULP3,IFT122,WDR19,OFD1,SEL1L,IFT140,PSMB2,GSK3B,EFCAB7,PSMD6,PSME3,PSMC5,PSMC1,NUMB,BTRC,PRKAR1A
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	0.00411364234090625	-5.49344642859764	31	16	0.0070298769771529	2276	8202	5903,4927,23511,7514,55746,8480,53371,23636,9972,9631,8021,9818,23165,129401,8086,3304	RANBP2,NUP88,NUP188,XPO1,NUP133,RAE1,NUP54,NUP62,NUP153,NUP155,NUP214,NUP58,NUP205,NUP35,AAAS,HSPA1B
R-HSA-180746	Nuclear import of Rev protein	0.00411364234090625	-5.49344642859764	31	16	0.0070298769771529	2276	8202	5903,4927,23511,55746,8480,53371,4869,23636,9972,9631,8021,9818,23165,129401,3837,8086	RANBP2,NUP88,NUP188,NUP133,RAE1,NUP54,NPM1,NUP62,NUP153,NUP155,NUP214,NUP58,NUP205,NUP35,KPNB1,AAAS
R-HSA-6783310	Fanconi Anemia Pathway	0.00422417053556128	-5.46693236039095	39	19	0.00834797891036907	2276	8202	2067,7311,2176,2177,57697,2189,55215,7316,6118,29089,64858,6233,91442,80233,199990,84126,545,7398,7314	ERCC1,UBA52,FANCC,FANCD2,FANCM,FANCG,FANCI,UBC,RPA2,UBE2T,DCLRE1B,RPS27A,FAAP24,FAAP100,FAAP20,ATRIP,ATR,USP1,UBB
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.00422417053556128	-5.46693236039095	39	19	0.00834797891036907	2276	8202	5883,5984,5983,5810,11073,83990,144715,7156,1111,5884,641,5982,9156,6118,5889,675,7516,84126,545	RAD9A,RFC4,RFC3,RAD1,TOPBP1,BRIP1,RAD9B,TOP3A,CHEK1,RAD17,BLM,RFC2,EXO1,RPA2,RAD51C,BRCA2,XRCC2,ATRIP,ATR
R-HSA-165159	mTOR signalling	0.00422417053556128	-5.46693236039095	39	19	0.00834797891036907	2276	8202	5564,1975,2475,208,5565,5562,5571,84335,6009,7248,51422,28956,389541,6194,5494,81617,6198,1977,64223	PRKAB1,EIF4B,MTOR,AKT2,PRKAB2,PRKAA1,PRKAG1,AKT1S1,RHEB,TSC1,PRKAG2,LAMTOR2,LAMTOR4,RPS6,PPM1A,CAB39L,RPS6KB1,EIF4E,MLST8
R-HSA-69166	Removal of the Flap Intermediate	0.00466419118506344	-5.3678408391224	14	9	0.00395430579964851	2276	8202	23649,6118,5111,5422,57804,5424,10714,2237,5425	POLA2,RPA2,PCNA,POLA1,POLD4,POLD1,POLD3,FEN1,POLD2
R-HSA-379724	tRNA Aminoacylation	0.0046852487251716	-5.36333627501652	42	20	0.00878734622144113	2276	8202	79731,51520,124454,2617,57505,10667,16,80222,7453,54938,2193,2058,5917,3376,27068,23438,10056,7965,9521,79587	NARS2,LARS,EARS2,GARS,AARS2,FARS2,AARS,TARS2,WARS,SARS2,FARSA,EPRS,RARS,IARS,PPA2,HARS2,FARSB,AIMP2,EEF1E1,CARS2
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.0046852487251716	-5.36333627501652	42	20	0.00878734622144113	2276	8202	5883,5984,5983,5810,11073,83990,144715,7156,1111,5884,641,5982,9156,6118,5889,675,7516,84126,7517,545	RAD9A,RFC4,RFC3,RAD1,TOPBP1,BRIP1,RAD9B,TOP3A,CHEK1,RAD17,BLM,RFC2,EXO1,RPA2,RAD51C,BRCA2,XRCC2,ATRIP,XRCC3,ATR
R-HSA-113418	Formation of the Early Elongation Complex	0.00478158976241683	-5.34298220149366	34	17	0.00746924428822496	2276	8202	9150,902,7936,5440,2071,7469,6829,5430,2962,5432,4686,2968,2963,5434,2965,2068,5431	CTDP1,CCNH,NELFE,POLR2K,ERCC3,NELFA,SUPT5H,POLR2A,GTF2F1,POLR2C,NCBP1,GTF2H4,GTF2F2,POLR2E,GTF2H1,ERCC2,POLR2B
R-HSA-177243	Interactions of Rev with host cellular proteins	0.00478158976241683	-5.34298220149366	34	17	0.00746924428822496	2276	8202	5903,4927,23511,7514,55746,8480,53371,4869,23636,9972,9631,8021,9818,23165,129401,3837,8086	RANBP2,NUP88,NUP188,XPO1,NUP133,RAE1,NUP54,NPM1,NUP62,NUP153,NUP155,NUP214,NUP58,NUP205,NUP35,KPNB1,AAAS
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	0.00478158976241683	-5.34298220149366	34	17	0.00746924428822496	2276	8202	9150,902,2071,5440,7936,7469,6829,5430,2962,5432,4686,2968,5434,2963,2965,2068,5431	CTDP1,CCNH,ERCC3,POLR2K,NELFE,NELFA,SUPT5H,POLR2A,GTF2F1,POLR2C,NCBP1,GTF2H4,POLR2E,GTF2F2,GTF2H1,ERCC2,POLR2B
R-HSA-2990846	SUMOylation	0.00487844650036653	-5.32292844988687	79	33	0.0144991212653779	2276	8202	23511,23137,10274,8480,53371,5893,9631,641,7329,8021,56160,23165,6015,129401,59343,7341,1069,5903,4927,6996,57332,55746,197370,286053,8243,23636,493861,9972,165918,9818,1029,8086,1911	NUP188,SMC5,STAG1,RAE1,NUP54,RAD52,NUP155,BLM,UBE2I,NUP214,NDNL2,NUP205,RING1,NUP35,SENP2,SUMO1,CETN2,RANBP2,NUP88,TDG,CBX8,NUP133,NSMCE1,NSMCE2,SMC1A,NUP62,EID3,NUP153,RNF168,NUP58,CDKN2A,AAAS,PHC1
R-HSA-212165	Epigenetic regulation of gene expression	0.00501241682870064	-5.29583707926504	124	48	0.0210896309314587	2276	8202	3015,5440,8367,6908,2071,25885,8350,25942,7270,23378,8347,5252,8360,8365,79595,6996,2968,8364,653604,2965,2068,3017,64425,8331,8819,23309,23411,902,5931,723790,11176,85236,3021,8340,8363,8368,221830,7343,3012,8362,51082,5434,3014,10284,128312,22823,3066,3720	H2AFZ,POLR2K,HIST1H4E,TBP,ERCC3,POLR1A,HIST1H3A,SIN3A,TTF1,RRP8,HIST1H2BC,PHF1,HIST1H4D,HIST1H4H,SAP130,TDG,GTF2H4,HIST1H4C,HIST2H3D,GTF2H1,ERCC2,HIST1H2BD,POLR1E,HIST1H2AJ,SAP30,SIN3B,SIRT1,CCNH,RBBP7,HIST2H2AA4,BAZ2A,HIST1H2BK,H3F3B,HIST1H2BL,HIST1H4J,HIST1H4L,TWISTNB,UBTF,HIST1H2AE,HIST1H4K,POLR1D,POLR2E,H2AFX,SAP18,HIST3H2BB,MTF2,HDAC2,JARID2
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	0.0052785520003159	-5.24410346123969	29	15	0.00659050966608084	2276	8202	5903,4927,23511,7514,55746,8480,53371,23636,9972,9631,8021,9818,23165,129401,8086	RANBP2,NUP88,NUP188,XPO1,NUP133,RAE1,NUP54,NUP62,NUP153,NUP155,NUP214,NUP58,NUP205,NUP35,AAAS
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	0.0052785520003159	-5.24410346123969	29	15	0.00659050966608084	2276	8202	5903,4927,23511,55746,8480,53371,23636,9972,9631,8021,9818,23165,129401,8086,3837	RANBP2,NUP88,NUP188,NUP133,RAE1,NUP54,NUP62,NUP153,NUP155,NUP214,NUP58,NUP205,NUP35,AAAS,KPNB1
R-HSA-73762	RNA Polymerase I Transcription Initiation	0.0054997477252727	-5.20305305592792	48	22	0.00966608084358524	2276	8202	57459,902,5931,5440,6908,2071,9219,25885,53615,7270,221830,54815,7343,54700,2968,2074,51082,5434,2965,2068,64425,3066	GATAD2B,CCNH,RBBP7,POLR2K,TBP,ERCC3,MTA2,POLR1A,MBD3,TTF1,TWISTNB,GATAD2A,UBTF,RRN3,GTF2H4,ERCC6,POLR1D,POLR2E,GTF2H1,ERCC2,POLR1E,HDAC2
R-HSA-69618	Mitotic Spindle Checkpoint	0.00551016528244512	-5.20116065945321	19	11	0.00483304042179262	2276	8202	51433,996,991,4085,10393,8379,29882,51434,701,8697,11065	ANAPC5,CDC27,CDC20,MAD2L1,ANAPC10,MAD1L1,ANAPC2,ANAPC7,BUB1B,CDC23,UBE2C
R-HSA-71403	Citric acid cycle (TCA cycle)	0.00551016528244512	-5.20116065945321	19	11	0.00483304042179262	2276	8202	50,8802,6391,4191,2271,1431,4967,3420,1743,1738,6392	ACO2,SUCLG1,SDHC,MDH2,FH,CS,OGDH,IDH3B,DLST,DLD,SDHD
R-HSA-70268	Pyruvate metabolism	0.00559389665292686	-5.18607915900176	24	13	0.00571177504393673	2276	8202	5160,5467,5164,5163,54704,5166,3939,6566,57546,682,2739,1738,3029	PDHA1,PPARD,PDK2,PDK1,PDP1,PDK4,LDHA,SLC16A1,PDP2,BSG,GLO1,DLD,HAGH
R-HSA-937041	IKK complex recruitment mediated by RIP1	0.00559389665292686	-5.18607915900176	24	13	0.00571177504393673	2276	8202	7323,8517,7311,330,6233,3551,7322,1147,7335,7314,7334,329,7316	UBE2D3,IKBKG,UBA52,BIRC3,RPS27A,IKBKB,UBE2D2,CHUK,UBE2V1,UBB,UBE2N,BIRC2,UBC
R-HSA-3371511	HSF1 activation	0.00561897848671963	-5.18160539552649	12	8	0.00351493848857645	2276	8202	6118,3326,10728,3320,10013,7531,1915,7415	RPA2,HSP90AB1,PTGES3,HSP90AA1,HDAC6,YWHAE,EEF1A1,VCP
R-HSA-174414	Processive synthesis on the C-strand of the telomere	0.00561897848671963	-5.18160539552649	12	8	0.00351493848857645	2276	8202	6118,5111,3978,57804,5424,10714,2237,5425	RPA2,PCNA,LIG1,POLD4,POLD1,POLD3,FEN1,POLD2
R-HSA-381033	ATF6-alpha activates chaperones	0.00561897848671963	-5.18160539552649	12	8	0.00351493848857645	2276	8202	811,468,7184,3309,7494,4802,22926,1649	CALR,ATF4,HSP90B1,HSPA5,XBP1,NFYC,ATF6,DDIT3
R-HSA-204626	Hypusine synthesis from eIF5A-lysine	0.00591809918033898	-5.12973996604705	4	4	0.00175746924428822	2276	8202	83475,1984,1725,56648	DOHH,EIF5A,DHPS,EIF5A2
R-HSA-1855191	Synthesis of IPs in the nucleus	0.00591809918033898	-5.12973996604705	4	4	0.00175746924428822	2276	8202	64768,51447,9807,253430	IPPK,IP6K2,IP6K1,IPMK
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	0.00594772254525002	-5.12474689820221	74	31	0.0136203866432337	2276	8202	7311,9682,8367,29086,7157,85236,9025,8363,8340,7329,8368,8347,8360,7316,7341,8365,8362,23030,7336,7158,6233,8364,3014,9031,51720,165918,11200,7314,128312,3017,7334	UBA52,KDM4A,HIST1H4E,BABAM1,TP53,HIST1H2BK,RNF8,HIST1H4J,HIST1H2BL,UBE2I,HIST1H4L,HIST1H2BC,HIST1H4D,UBC,SUMO1,HIST1H4H,HIST1H4K,KDM4B,UBE2V2,TP53BP1,RPS27A,HIST1H4C,H2AFX,BAZ1B,UIMC1,RNF168,CHEK2,UBB,HIST3H2BB,HIST1H2BD,UBE2N
R-HSA-5675221	Negative regulation of MAPK pathway	0.00598459893182132	-5.11856595444463	40	19	0.00834797891036907	2276	8202	7311,673,1848,5894,5604,3845,5526,1847,4140,7316,5529,369,5518,6233,5527,11221,7314,5528,1843	UBA52,BRAF,DUSP6,RAF1,MAP2K1,KRAS,PPP2R5B,DUSP5,MARK3,UBC,PPP2R5E,ARAF,PPP2R1A,RPS27A,PPP2R5C,DUSP10,UBB,PPP2R5D,DUSP1
R-HSA-109703	PKB-mediated events	0.00598459893182132	-5.11856595444463	40	19	0.00834797891036907	2276	8202	5564,1975,2475,208,5565,5562,5571,84335,6009,7248,51422,28956,389541,6194,5494,81617,6198,1977,64223	PRKAB1,EIF4B,MTOR,AKT2,PRKAB2,PRKAA1,PRKAG1,AKT1S1,RHEB,TSC1,PRKAG2,LAMTOR2,LAMTOR4,RPS6,PPM1A,CAB39L,RPS6KB1,EIF4E,MLST8
R-HSA-73854	RNA Polymerase I Promoter Clearance	0.00628109807667862	-5.07021046081273	107	42	0.0184534270650264	2276	8202	3015,5440,8367,6908,2071,25885,8350,7270,8347,8360,8365,54815,54700,2968,8364,653604,2965,2068,3017,64425,8331,57459,902,5931,723790,9219,85236,3021,8340,8363,8368,53615,221830,7343,3012,8362,2074,51082,5434,3014,128312,3066	H2AFZ,POLR2K,HIST1H4E,TBP,ERCC3,POLR1A,HIST1H3A,TTF1,HIST1H2BC,HIST1H4D,HIST1H4H,GATAD2A,RRN3,GTF2H4,HIST1H4C,HIST2H3D,GTF2H1,ERCC2,HIST1H2BD,POLR1E,HIST1H2AJ,GATAD2B,CCNH,RBBP7,HIST2H2AA4,MTA2,HIST1H2BK,H3F3B,HIST1H2BL,HIST1H4J,HIST1H4L,MBD3,TWISTNB,UBTF,HIST1H2AE,HIST1H4K,ERCC6,POLR1D,POLR2E,H2AFX,HIST3H2BB,HDAC2
R-HSA-427413	NoRC negatively regulates rRNA expression	0.0063067437617482	-5.06613577972255	104	41	0.0180140597539543	2276	8202	3015,5440,8367,6908,2071,25885,8350,25942,7270,8347,8360,8365,79595,2968,8364,2965,653604,2068,3017,64425,8331,8819,23309,902,723790,11176,85236,3021,8340,8363,8368,221830,7343,3012,8362,51082,5434,3014,10284,128312,3066	H2AFZ,POLR2K,HIST1H4E,TBP,ERCC3,POLR1A,HIST1H3A,SIN3A,TTF1,HIST1H2BC,HIST1H4D,HIST1H4H,SAP130,GTF2H4,HIST1H4C,GTF2H1,HIST2H3D,ERCC2,HIST1H2BD,POLR1E,HIST1H2AJ,SAP30,SIN3B,CCNH,HIST2H2AA4,BAZ2A,HIST1H2BK,H3F3B,HIST1H2BL,HIST1H4J,HIST1H4L,TWISTNB,UBTF,HIST1H2AE,HIST1H4K,POLR1D,POLR2E,H2AFX,SAP18,HIST3H2BB,HDAC2
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.00651114065337057	-5.0342406225386	43	20	0.00878734622144113	2276	8202	7323,1030,7050,7311,1024,1875,4092,23327,8239,7316,51592,6498,6233,5933,4609,3726,54778,5494,7314,6667	UBE2D3,CDKN2B,TGIF1,UBA52,CDK8,E2F5,SMAD7,NEDD4L,USP9X,UBC,TRIM33,SKIL,RPS27A,RBL1,MYC,JUNB,RNF111,PPM1A,UBB,SP1
R-HSA-937042	IRAK2 mediated activation of TAK1 complex	0.0066024345522996	-5.0203168264056	10	7	0.00307557117750439	2276	8202	7311,6885,7314,10454,257397,6233,7316	UBA52,MAP3K7,UBB,TAB1,TAB3,RPS27A,UBC
R-HSA-174437	Removal of the Flap Intermediate from the C-strand	0.0066024345522996	-5.0203168264056	10	7	0.00307557117750439	2276	8202	6118,5111,10714,5424,57804,5425,2237	RPA2,PCNA,POLD3,POLD1,POLD4,POLD2,FEN1
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	0.0066024345522996	-5.0203168264056	10	7	0.00307557117750439	2276	8202	7311,6885,7314,10454,257397,6233,7316	UBA52,MAP3K7,UBB,TAB1,TAB3,RPS27A,UBC
R-HSA-176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.00697554586619821	-4.96534469395005	17	10	0.00439367311072056	2276	8202	51433,996,51343,991,10393,51434,29882,8697,11065,8556	ANAPC5,CDC27,FZR1,CDC20,ANAPC10,ANAPC7,ANAPC2,CDC23,UBE2C,CDC14A
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	0.00697554586619821	-4.96534469395005	17	10	0.00439367311072056	2276	8202	811,9761,5589,11253,80267,6400,56886,84447,821,23193	CALR,MLEC,PRKCSH,MAN1B1,EDEM3,SEL1L,UGGT1,SYVN1,CANX,GANAB
R-HSA-72731	Recycling of eIF2:GDP	0.00741414342337708	-4.9043658295018	8	6	0.00263620386643234	2276	8202	8892,8893,8894,8891,1968,1967	EIF2B2,EIF2B5,EIF2S2,EIF2B3,EIF2S3,EIF2B1
R-HSA-5693606	DNA Double Strand Break Response	0.00749624258681112	-4.89335337240169	75	31	0.0136203866432337	2276	8202	7311,9682,8367,29086,7157,85236,9025,8363,8340,7329,8368,8347,8360,7316,7341,8365,8362,23030,7336,7158,6233,8364,3014,9031,51720,165918,11200,7314,128312,3017,7334	UBA52,KDM4A,HIST1H4E,BABAM1,TP53,HIST1H2BK,RNF8,HIST1H4J,HIST1H2BL,UBE2I,HIST1H4L,HIST1H2BC,HIST1H4D,UBC,SUMO1,HIST1H4H,HIST1H4K,KDM4B,UBE2V2,TP53BP1,RPS27A,HIST1H4C,H2AFX,BAZ1B,UIMC1,RNF168,CHEK2,UBB,HIST3H2BB,HIST1H2BD,UBE2N
R-HSA-6782861	Synthesis of wybutosine at G37 of tRNA(Phe)	0.00756884508736547	-4.88371478758863	6	5	0.00219683655536028	2276	8202	127253,55039,55253,129450,9836	TYW3,TRMT12,TYW1,TYW5,LCMT2
R-HSA-68616	Assembly of the ORC complex at the origin of replication	0.00756884508736547	-4.88371478758863	6	5	0.00219683655536028	2276	8202	4999,4998,5000,23595,5001	ORC2,ORC1,ORC4,ORC3,ORC5
R-HSA-109606	Intrinsic Pathway for Apoptosis	0.00765105065388302	-4.87291230019715	38	18	0.00790861159929701	2276	8202	4836,90427,208,8655,842,7157,56616,10971,54205,598,7531,7532,572,840,5366,581,7534,7533	NMT1,BMF,AKT2,DYNLL1,CASP9,TP53,DIABLO,YWHAQ,CYCS,BCL2L1,YWHAE,YWHAG,BAD,CASP7,PMAIP1,BAX,YWHAZ,YWHAH
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	0.00773162519191477	-4.86243619373149	96	38	0.0166959578207381	2276	8202	23291,5689,5693,7186,5713,1147,5715,329,9491,8771,5687,5696,5707,5971,5717,7314,4791,5686,5694,7311,330,5692,5702,5695,5682,5710,7316,5691,5719,6233,5709,5714,5690,5705,9861,10197,5700,8945	FBXW11,PSMB1,PSMB5,TRAF2,PSMD7,CHUK,PSMD9,BIRC2,PSMF1,TNFRSF6B,PSMA6,PSMB8,PSMD1,RELB,PSMD11,UBB,NFKB2,PSMA5,PSMB6,UBA52,BIRC3,PSMB4,PSMC3,PSMB7,PSMA1,PSMD4,UBC,PSMB3,PSMD13,RPS27A,PSMD3,PSMD8,PSMB2,PSMC5,PSMD6,PSME3,PSMC1,BTRC
R-HSA-5625740	RHO GTPases activate PKNs	0.00774261426638646	-4.8610158878937	90	36	0.015817223198594	2276	8202	3015,4659,8367,4627,8350,7531,4628,8347,8360,23028,8365,5586,8364,4637,653604,3017,8331,5170,723790,85236,10971,3021,8340,8363,8368,995,7532,8362,3012,3014,5500,4660,7534,128312,7533,23081	H2AFZ,PPP1R12A,HIST1H4E,MYH9,HIST1H3A,YWHAE,MYH10,HIST1H2BC,HIST1H4D,KDM1A,HIST1H4H,PKN2,HIST1H4C,MYL6,HIST2H3D,HIST1H2BD,HIST1H2AJ,PDPK1,HIST2H2AA4,HIST1H2BK,YWHAQ,H3F3B,HIST1H2BL,HIST1H4J,HIST1H4L,CDC25C,YWHAG,HIST1H4K,HIST1H2AE,H2AFX,PPP1CB,PPP1R12B,YWHAZ,HIST3H2BB,YWHAH,KDM4C
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation	0.00788667302372978	-4.84258090304837	30	15	0.00659050966608084	2276	8202	5432,8178,9150,5440,7936,2963,5434,6921,6917,6829,7469,5431,5430,2962,11198	POLR2C,ELL,CTDP1,POLR2K,NELFE,GTF2F2,POLR2E,TCEB1,TCEA1,SUPT5H,NELFA,POLR2B,POLR2A,GTF2F1,SUPT16H
R-HSA-72086	mRNA Capping	0.00788667302372978	-4.84258090304837	30	15	0.00659050966608084	2276	8202	5432,4686,902,2968,5440,8731,2071,5434,2963,2965,2068,6829,5431,5430,2962	POLR2C,NCBP1,CCNH,GTF2H4,POLR2K,RNMT,ERCC3,POLR2E,GTF2F2,GTF2H1,ERCC2,SUPT5H,POLR2B,POLR2A,GTF2F1
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery	0.00788667302372978	-4.84258090304837	30	15	0.00659050966608084	2276	8202	5432,8178,9150,5440,7936,2963,5434,6921,6917,6829,7469,5431,5430,2962,11198	POLR2C,ELL,CTDP1,POLR2K,NELFE,GTF2F2,POLR2E,TCEB1,TCEA1,SUPT5H,NELFA,POLR2B,POLR2A,GTF2F1,SUPT16H
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.00867531986265522	-4.74727308205314	121	46	0.0202108963093146	2276	8202	7323,23291,3146,1848,257397,5604,4205,1147,9252,329,5606,3725,466,6196,8651,5518,3551,5601,5781,1785,6885,4791,7314,5598,1386,5970,7311,8767,5609,330,7867,51295,7335,246330,2002,2353,7316,8772,8517,6233,5608,7322,10454,5528,7334,8945	UBE2D3,FBXW11,HMGB1,DUSP6,TAB3,MAP2K1,MEF2A,CHUK,RPS6KA5,BIRC2,MAP2K3,JUN,ATF1,RPS6KA2,SOCS1,PPP2R1A,IKBKB,MAPK9,PTPN11,DNM2,MAP3K7,NFKB2,UBB,MAPK7,ATF2,RELA,UBA52,RIPK2,MAP2K7,BIRC3,MAPKAPK3,ECSIT,UBE2V1,PELI3,ELK1,FOS,UBC,FADD,IKBKG,RPS27A,MAP2K6,UBE2D2,TAB1,PPP2R5D,UBE2N,BTRC
R-HSA-162588	Budding and maturation of HIV virion	0.00873127301372939	-4.74084409917386	25	13	0.00571177504393673	2276	8202	27243,7311,6233,51534,79720,9525,7251,23327,51652,7314,25978,7316,5478	CHMP2A,UBA52,RPS27A,VTA1,VPS37B,VPS4B,TSG101,NEDD4L,CHMP3,UBB,CHMP2B,UBC,PPIA
R-HSA-5358751	S45 mutants of beta-catenin aren't phosphorylated	0.00880861858957046	-4.73202465160427	15	9	0.00395430579964851	2276	8202	5529,1499,5518,2932,5527,324,5526,1452,5528	PPP2R5E,CTNNB1,PPP2R1A,GSK3B,PPP2R5C,APC,PPP2R5B,CSNK1A1,PPP2R5D
R-HSA-5358747	S33 mutants of beta-catenin aren't phosphorylated	0.00880861858957046	-4.73202465160427	15	9	0.00395430579964851	2276	8202	5529,1499,5518,2932,5527,324,5526,1452,5528	PPP2R5E,CTNNB1,PPP2R1A,GSK3B,PPP2R5C,APC,PPP2R5B,CSNK1A1,PPP2R5D
R-HSA-901042	Calnexin/calreticulin cycle	0.00880861858957046	-4.73202465160427	15	9	0.00395430579964851	2276	8202	811,5589,11253,80267,6400,84447,56886,821,23193	CALR,PRKCSH,MAN1B1,EDEM3,SEL1L,SYVN1,UGGT1,CANX,GANAB
R-HSA-4839743	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	0.00880861858957046	-4.73202465160427	15	9	0.00395430579964851	2276	8202	5529,1499,5518,2932,5527,324,5526,1452,5528	PPP2R5E,CTNNB1,PPP2R1A,GSK3B,PPP2R5C,APC,PPP2R5B,CSNK1A1,PPP2R5D
R-HSA-5358752	T41 mutants of beta-catenin aren't phosphorylated	0.00880861858957046	-4.73202465160427	15	9	0.00395430579964851	2276	8202	5529,1499,5518,2932,5527,324,5526,1452,5528	PPP2R5E,CTNNB1,PPP2R1A,GSK3B,PPP2R5C,APC,PPP2R5B,CSNK1A1,PPP2R5D
R-HSA-5358749	S37 mutants of beta-catenin aren't phosphorylated	0.00880861858957046	-4.73202465160427	15	9	0.00395430579964851	2276	8202	5529,1499,5518,2932,5527,324,5526,1452,5528	PPP2R5E,CTNNB1,PPP2R1A,GSK3B,PPP2R5C,APC,PPP2R5B,CSNK1A1,PPP2R5D
R-HSA-5339716	Misspliced GSK3beta mutants stabilize beta-catenin	0.00880861858957046	-4.73202465160427	15	9	0.00395430579964851	2276	8202	5529,1499,5518,2932,5527,324,5526,1452,5528	PPP2R5E,CTNNB1,PPP2R1A,GSK3B,PPP2R5C,APC,PPP2R5B,CSNK1A1,PPP2R5D
R-HSA-446652	Interleukin-1 signaling	0.00887797646977946	-4.72418162297035	44	20	0.00878734622144113	2276	8202	4215,23291,7311,8767,257397,5604,1147,7335,246330,7316,8517,8878,6233,5608,3551,7314,6885,10454,7334,8945	MAP3K3,FBXW11,UBA52,RIPK2,TAB3,MAP2K1,CHUK,UBE2V1,PELI3,UBC,IKBKG,SQSTM1,RPS27A,MAP2K6,IKBKB,UBB,MAP3K7,TAB1,UBE2N,BTRC
R-HSA-113510	E2F mediated regulation of DNA replication	0.00889084324990967	-4.72273338019654	33	16	0.0070298769771529	2276	8202	23649,8318,993,4999,5111,5000,5518,5422,5001,84515,6241,990,4998,23595,983,26271	POLA2,CDC45,CDC25A,ORC2,PCNA,ORC4,PPP2R1A,POLA1,ORC5,MCM8,RRM2,CDC6,ORC1,ORC3,CDK1,FBXO5
R-HSA-5694530	Cargo concentration in the ER	0.00889084324990967	-4.72273338019654	33	16	0.0070298769771529	2276	8202	10802,966,51128,10484,10972,9871,9632,375056,4253,9554,10960,1294,90411,10959,10113,6811	SEC24A,CD59,SAR1B,SEC23A,TMED10,SEC24D,SEC24C,MIA3,CTAGE5,SEC22B,LMAN2,COL7A1,MCFD2,TMED2,PREB,STX5
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	0.0089891955989146	-4.71173191181956	168	61	0.0268014059753954	2276	8202	23291,23112,5689,5693,2475,5966,5713,1147,84335,23239,5715,9491,5707,5696,5687,3551,5296,5781,1027,8503,5717,145957,253260,2065,6885,7314,5970,5686,64223,6199,5694,5170,7311,5692,2931,3164,208,842,5702,5695,10892,5682,3845,5710,5691,7316,572,8517,5719,6233,5714,5709,2932,5690,5705,10197,9861,4343,5700,8945,192669	FBXW11,TNRC6B,PSMB1,PSMB5,MTOR,REL,PSMD7,CHUK,AKT1S1,PHLPP1,PSMD9,PSMF1,PSMD1,PSMB8,PSMA6,IKBKB,PIK3R2,PTPN11,CDKN1B,PIK3R3,PSMD11,NRG4,RICTOR,ERBB3,MAP3K7,UBB,RELA,PSMA5,MLST8,RPS6KB2,PSMB6,PDPK1,UBA52,PSMB4,GSK3A,NR4A1,AKT2,CASP9,PSMC3,PSMB7,MALT1,PSMA1,KRAS,PSMD4,PSMB3,UBC,BAD,IKBKG,PSMD13,RPS27A,PSMD8,PSMD3,GSK3B,PSMB2,PSMC5,PSME3,PSMD6,MOV10,PSMC1,BTRC,AGO3
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	0.00916851093907617	-4.69198038986063	70	29	0.0127416520210896	2276	8202	1058,3015,723790,5931,8367,85236,4869,8363,51773,8340,8368,55320,8347,8360,79682,79172,91687,8365,401541,3012,8362,8607,8364,3014,79019,128312,57082,3017,8331	CENPA,H2AFZ,HIST2H2AA4,RBBP7,HIST1H4E,HIST1H2BK,NPM1,HIST1H4J,RSF1,HIST1H2BL,HIST1H4L,MIS18BP1,HIST1H2BC,HIST1H4D,CENPU,CENPO,CENPL,HIST1H4H,CENPP,HIST1H2AE,HIST1H4K,RUVBL1,HIST1H4C,H2AFX,CENPM,HIST3H2BB,CASC5,HIST1H2BD,HIST1H2AJ
R-HSA-774815	Nucleosome assembly	0.00916851093907617	-4.69198038986063	70	29	0.0127416520210896	2276	8202	1058,3015,723790,5931,8367,85236,4869,8363,51773,8340,8368,55320,8347,8360,79682,79172,91687,8365,401541,3012,8362,8607,8364,3014,79019,128312,57082,3017,8331	CENPA,H2AFZ,HIST2H2AA4,RBBP7,HIST1H4E,HIST1H2BK,NPM1,HIST1H4J,RSF1,HIST1H2BL,HIST1H4L,MIS18BP1,HIST1H2BC,HIST1H4D,CENPU,CENPO,CENPL,HIST1H4H,CENPP,HIST1H2AE,HIST1H4K,RUVBL1,HIST1H4C,H2AFX,CENPM,HIST3H2BB,CASC5,HIST1H2BD,HIST1H2AJ
R-HSA-168898	Toll-Like Receptors Cascades	0.00928461945080283	-4.67939607039135	140	52	0.0228471001757469	2276	8202	7323,23291,3146,7184,1848,257397,5604,30849,4205,1147,9252,329,8411,5606,3725,466,6196,8651,5518,3551,5601,5781,1785,6885,4791,5598,7314,1386,5970,5289,7311,8767,5609,330,7867,51295,7335,246330,2002,2353,7316,8772,8517,64145,6233,5608,7322,10454,5528,170506,7334,8945	UBE2D3,FBXW11,HMGB1,HSP90B1,DUSP6,TAB3,MAP2K1,PIK3R4,MEF2A,CHUK,RPS6KA5,BIRC2,EEA1,MAP2K3,JUN,ATF1,RPS6KA2,SOCS1,PPP2R1A,IKBKB,MAPK9,PTPN11,DNM2,MAP3K7,NFKB2,MAPK7,UBB,ATF2,RELA,PIK3C3,UBA52,RIPK2,MAP2K7,BIRC3,MAPKAPK3,ECSIT,UBE2V1,PELI3,ELK1,FOS,UBC,FADD,IKBKG,RBSN,RPS27A,MAP2K6,UBE2D2,TAB1,PPP2R5D,DHX36,UBE2N,BTRC
R-HSA-4086400	PCP/CE pathway	0.00946067537450671	-4.6606115058127	91	36	0.015817223198594	2276	8202	5689,5693,5713,2535,5715,9491,5707,5687,5696,163,5717,7314,1856,5686,5694,8321,7311,5692,5702,5695,5682,5710,5691,7316,5719,6233,5709,160,5714,1213,5690,5705,10197,9861,5700,1175	PSMB1,PSMB5,PSMD7,FZD2,PSMD9,PSMF1,PSMD1,PSMA6,PSMB8,AP2B1,PSMD11,UBB,DVL2,PSMA5,PSMB6,FZD1,UBA52,PSMB4,PSMC3,PSMB7,PSMA1,PSMD4,PSMB3,UBC,PSMD13,RPS27A,PSMD3,AP2A1,PSMD8,CLTC,PSMB2,PSMC5,PSME3,PSMD6,PSMC1,AP2S1
R-HSA-191859	snRNP Assembly	0.00983063267185469	-4.62225198556612	50	22	0.00966608084358524	2276	8202	23511,8480,53371,9631,79084,6635,8021,23165,129401,1207,5903,4686,4927,55746,79833,23636,9972,6637,10419,6633,9818,8086	NUP188,RAE1,NUP54,NUP155,WDR77,SNRPE,NUP214,NUP205,NUP35,CLNS1A,RANBP2,NCBP1,NUP88,NUP133,GEMIN6,NUP62,NUP153,SNRPG,PRMT5,SNRPD2,NUP58,AAAS
R-HSA-194441	Metabolism of non-coding RNA	0.00983063267185469	-4.62225198556612	50	22	0.00966608084358524	2276	8202	23511,8480,53371,9631,79084,6635,8021,23165,129401,1207,5903,4686,4927,55746,79833,23636,9972,6637,10419,6633,9818,8086	NUP188,RAE1,NUP54,NUP155,WDR77,SNRPE,NUP214,NUP205,NUP35,CLNS1A,RANBP2,NCBP1,NUP88,NUP133,GEMIN6,NUP62,NUP153,SNRPG,PRMT5,SNRPD2,NUP58,AAAS
R-HSA-5218920	VEGFR2 mediated vascular permeability	0.0101528255585985	-4.59000323207742	28	14	0.00615114235500879	2276	8202	5170,805,5058,10451,3728,1499,2475,208,1495,1500,253260,857,3320,64223	PDPK1,CALM2,PAK1,VAV3,JUP,CTNNB1,MTOR,AKT2,CTNNA1,CTNND1,RICTOR,CAV1,HSP90AA1,MLST8
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	0.0101528255585985	-4.59000323207742	28	14	0.00615114235500879	2276	8202	5432,902,2968,5440,8731,2071,5434,2963,2965,2068,6829,5431,5430,2962	POLR2C,CCNH,GTF2H4,POLR2K,RNMT,ERCC3,POLR2E,GTF2F2,GTF2H1,ERCC2,SUPT5H,POLR2B,POLR2A,GTF2F1
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE	0.0101528255585985	-4.59000323207742	28	14	0.00615114235500879	2276	8202	5432,902,2968,2071,5440,8731,2963,5434,2965,2068,6829,5431,5430,2962	POLR2C,CCNH,GTF2H4,ERCC3,POLR2K,RNMT,GTF2F2,POLR2E,GTF2H1,ERCC2,SUPT5H,POLR2B,POLR2A,GTF2F1
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	0.0110412469812246	-4.50611729331382	62	26	0.0114235500878735	2276	8202	51552,5564,6517,23433,208,5565,4012,5571,10971,7531,6810,8766,4641,7532,10890,805,4218,57148,51422,60412,6814,7534,55770,7533,9882,9847	RAB14,PRKAB1,SLC2A4,RHOQ,AKT2,PRKAB2,LNPEP,PRKAG1,YWHAQ,YWHAE,STX4,RAB11A,MYO1C,YWHAG,RAB10,CALM2,RAB8A,RALGAPB,PRKAG2,EXOC4,STXBP3,YWHAZ,EXOC2,YWHAH,TBC1D4,C2CD5
R-HSA-198323	AKT phosphorylates targets in the cytosol	0.0110766196787872	-4.50291872735228	13	8	0.00351493848857645	2276	8202	572,2931,208,842,2932,1027,1147,84335	BAD,GSK3A,AKT2,CASP9,GSK3B,CDKN1B,CHUK,AKT1S1
R-HSA-209543	p75NTR recruits signalling complexes	0.0110766196787872	-4.50291872735228	13	8	0.00351493848857645	2276	8202	7311,8878,8767,6233,3551,5584,7314,7316	UBA52,SQSTM1,RIPK2,RPS27A,IKBKB,PRKCI,UBB,UBC
R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	0.0110766196787872	-4.50291872735228	13	8	0.00351493848857645	2276	8202	7311,6233,208,10193,9101,2065,7314,7316	UBA52,RPS27A,AKT2,RNF41,USP8,ERBB3,UBB,UBC
R-HSA-5578749	Transcriptional regulation by small RNAs	0.0112118863158793	-4.49078078523516	101	39	0.0171353251318102	2276	8202	3015,23511,5440,8367,8480,53371,8350,8347,8360,23165,129401,8365,4927,55746,8364,653604,9972,3017,5431,8331,723790,85236,3021,9631,8340,8363,8368,8021,5430,5432,5903,3012,8362,3014,5434,23636,128312,9818,8086	H2AFZ,NUP188,POLR2K,HIST1H4E,RAE1,NUP54,HIST1H3A,HIST1H2BC,HIST1H4D,NUP205,NUP35,HIST1H4H,NUP88,NUP133,HIST1H4C,HIST2H3D,NUP153,HIST1H2BD,POLR2B,HIST1H2AJ,HIST2H2AA4,HIST1H2BK,H3F3B,NUP155,HIST1H2BL,HIST1H4J,HIST1H4L,NUP214,POLR2A,POLR2C,RANBP2,HIST1H2AE,HIST1H4K,H2AFX,POLR2E,NUP62,HIST3H2BB,NUP58,AAAS
R-HSA-73980	RNA Polymerase III Transcription Termination	0.0112602976861052	-4.48647221913291	23	12	0.00527240773286467	2276	8202	661,5440,51082,171568,5434,4774,4782,55703,4781,51728,11128,10621	POLR3D,POLR2K,POLR1D,POLR3H,POLR2E,NFIA,NFIC,POLR3B,NFIB,POLR3K,POLR3A,POLR3F
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.0112602976861052	-4.48647221913291	23	12	0.00527240773286467	2276	8202	7323,6498,51592,7050,7311,6233,54778,5494,23327,7314,8239,7316	UBE2D3,SKIL,TRIM33,TGIF1,UBA52,RPS27A,RNF111,PPM1A,NEDD4L,UBB,USP9X,UBC
R-HSA-167242	Abortive elongation of HIV-1 transcript in the absence of Tat	0.0112602976861052	-4.48647221913291	23	12	0.00527240773286467	2276	8202	5432,9150,4686,5440,7936,2963,5434,7469,6829,5431,5430,2962	POLR2C,CTDP1,NCBP1,POLR2K,NELFE,GTF2F2,POLR2E,NELFA,SUPT5H,POLR2B,POLR2A,GTF2F1
R-HSA-75067	Processing of Capped Intronless Pre-mRNA	0.0112602976861052	-4.48647221913291	23	12	0.00527240773286467	2276	8202	25888,4686,11051,10978,7884,1478,6635,51585,6637,51692,84967,1477	ZNF473,NCBP1,NUDT21,CLP1,SLBP,CSTF2,SNRPE,PCF11,SNRPG,CPSF3,LSM10,CSTF1
R-HSA-167287	HIV elongation arrest and recovery	0.0114238892887976	-4.47204856453852	31	15	0.00659050966608084	2276	8202	5432,8178,9150,5440,7936,2963,5434,6921,6917,6829,7469,5431,5430,2962,11198	POLR2C,ELL,CTDP1,POLR2K,NELFE,GTF2F2,POLR2E,TCEB1,TCEA1,SUPT5H,NELFA,POLR2B,POLR2A,GTF2F1,SUPT16H
R-HSA-167290	Pausing and recovery of HIV elongation	0.0114238892887976	-4.47204856453852	31	15	0.00659050966608084	2276	8202	5432,8178,9150,5440,7936,2963,5434,6921,6917,6829,7469,5431,5430,2962,11198	POLR2C,ELL,CTDP1,POLR2K,NELFE,GTF2F2,POLR2E,TCEB1,TCEA1,SUPT5H,NELFA,POLR2B,POLR2A,GTF2F1,SUPT16H
R-HSA-180910	Vpr-mediated nuclear import of PICs	0.0114238892887976	-4.47204856453852	31	15	0.00659050966608084	2276	8202	5903,4927,23511,55746,8480,53371,23636,9972,9631,3159,8021,9818,23165,129401,8086	RANBP2,NUP88,NUP188,NUP133,RAE1,NUP54,NUP62,NUP153,NUP155,HMGA1,NUP214,NUP58,NUP205,NUP35,AAAS
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	0.0118340269454906	-4.43677625777479	18	10	0.00439367311072056	2276	8202	51433,996,991,4085,10393,29882,51434,701,8697,11065	ANAPC5,CDC27,CDC20,MAD2L1,ANAPC10,ANAPC2,ANAPC7,BUB1B,CDC23,UBE2C
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	0.0118340269454906	-4.43677625777479	18	10	0.00439367311072056	2276	8202	7323,7311,112398,6233,8453,7322,6921,7314,112399,7316	UBE2D3,UBA52,EGLN2,RPS27A,CUL2,UBE2D2,TCEB1,UBB,EGLN3,UBC
R-HSA-141405	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	0.0118340269454906	-4.43677625777479	18	10	0.00439367311072056	2276	8202	51433,996,991,4085,10393,29882,51434,701,8697,11065	ANAPC5,CDC27,CDC20,MAD2L1,ANAPC10,ANAPC2,ANAPC7,BUB1B,CDC23,UBE2C
R-HSA-5620920	Cargo trafficking to the periciliary membrane	0.0128491374313517	-4.3544785958588	51	22	0.00966608084358524	2276	8202	10576,129880,585,7203,79738,55212,27241,8729,8766,10694,378,166379,10575,9727,84100,4218,5147,6950,200894,60412,92482,55770	CCT2,BBS5,BBS4,CCT3,BBS10,BBS7,BBS9,GBF1,RAB11A,CCT8,ARF4,BBS12,CCT4,RAB11FIP3,ARL6,RAB8A,PDE6D,TCP1,ARL13B,EXOC4,BBIP1,EXOC2
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	0.0130949299401338	-4.33553015116019	26	13	0.00571177504393673	2276	8202	7311,7514,9110,6233,51377,23645,4092,5500,23327,7314,11171,7316,9958	UBA52,XPO1,MTMR4,RPS27A,UCHL5,PPP1R15A,SMAD7,PPP1CB,NEDD4L,UBB,STRAP,UBC,USP15
R-HSA-2132295	MHC class II antigen presentation	0.0134021595552099	-4.31233942417372	102	39	0.0171353251318102	2276	8202	3122,11258,1781,6396,10120,9871,8655,10540,3831,29127,11004,84516,162,821,9632,51164,8907,1785,163,3835,1639,10802,10484,10112,7879,3109,3832,10671,22872,3796,3108,51128,24137,160,1213,51626,1062,164,1175	HLA-DRA,DCTN3,DYNC1I2,SEC13,ACTR1B,SEC24D,DYNLL1,DCTN2,KLC1,RACGAP1,KIF2C,DCTN5,AP1B1,CANX,SEC24C,DCTN4,AP1M1,DNM2,AP2B1,KIF22,DCTN1,SEC24A,SEC23A,KIF20A,RAB7A,HLA-DMB,KIF11,DCTN6,SEC31A,KIF2A,HLA-DMA,SAR1B,KIF4A,AP2A1,CLTC,DYNC2LI1,CENPE,AP1G1,AP2S1
R-HSA-5685938	HDR through Single Strand Annealing (SSA)	0.0135174900093088	-4.3037708758015	37	17	0.00746924428822496	2276	8202	5883,5984,2067,5983,5810,11073,83990,144715,7156,5893,5884,641,5982,9156,6118,84126,545	RAD9A,RFC4,ERCC1,RFC3,RAD1,TOPBP1,BRIP1,RAD9B,TOP3A,RAD52,RAD17,BLM,RFC2,EXO1,RPA2,ATRIP,ATR
R-HSA-73817	Purine ribonucleoside monophosphate biosynthesis	0.0138270880359383	-4.2811257096372	11	7	0.00307557117750439	2276	8202	159,3614,3615,2618,5198,5471,10606	ADSS,IMPDH1,IMPDH2,GART,PFAS,PPAT,PAICS
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	0.0140821507235508	-4.26284718966519	66	27	0.0118629173989455	2276	8202	3146,7311,51428,115004,5440,171568,1147,51728,11128,7316,7520,8517,661,1499,51082,6233,6778,3551,2547,5434,23220,55703,7314,4791,5970,170506,10621	HMGB1,UBA52,DDX41,MB21D1,POLR2K,POLR3H,CHUK,POLR3K,POLR3A,UBC,XRCC5,IKBKG,POLR3D,CTNNB1,POLR1D,RPS27A,STAT6,IKBKB,XRCC6,POLR2E,DTX4,POLR3B,UBB,NFKB2,RELA,DHX36,POLR3F
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	0.0147021475463588	-4.21976170427875	29	14	0.00615114235500879	2276	8202	5903,4927,23511,55746,8480,53371,23636,9631,9972,8021,9818,8086,23165,129401	RANBP2,NUP88,NUP188,NUP133,RAE1,NUP54,NUP62,NUP155,NUP153,NUP214,NUP58,AAAS,NUP205,NUP35
R-HSA-193639	p75NTR signals via NF-kB	0.0152303874830734	-4.1844626703059	16	9	0.00395430579964851	2276	8202	7311,8878,8767,6233,3551,5584,7314,5970,7316	UBA52,SQSTM1,RIPK2,RPS27A,IKBKB,PRKCI,UBB,RELA,UBC
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	0.0160892653457613	-4.12960297807797	32	15	0.00659050966608084	2276	8202	5903,4927,23511,7514,55746,8480,53371,23636,9972,9631,8021,9818,23165,129401,8086	RANBP2,NUP88,NUP188,XPO1,NUP133,RAE1,NUP54,NUP62,NUP153,NUP155,NUP214,NUP58,NUP205,NUP35,AAAS
R-HSA-73863	RNA Polymerase I Transcription Termination	0.0160892653457613	-4.12960297807797	32	15	0.00659050966608084	2276	8202	7343,902,284119,2968,5440,51082,6908,2071,25885,5434,2965,2068,7270,64425,221830	UBTF,CCNH,PTRF,GTF2H4,POLR2K,POLR1D,TBP,ERCC3,POLR1A,POLR2E,GTF2H1,ERCC2,TTF1,POLR1E,TWISTNB
R-HSA-171306	Packaging Of Telomere Ends	0.0161596674674097	-4.12523680361269	49	21	0.00922671353251318	2276	8202	3015,723790,8367,85236,8363,8340,8368,8347,8360,8365,54386,8362,3012,65057,8364,26277,3014,128312,3017,8331,7014	H2AFZ,HIST2H2AA4,HIST1H4E,HIST1H2BK,HIST1H4J,HIST1H2BL,HIST1H4L,HIST1H2BC,HIST1H4D,HIST1H4H,TERF2IP,HIST1H4K,HIST1H2AE,ACD,HIST1H4C,TINF2,H2AFX,HIST3H2BB,HIST1H2BD,HIST1H2AJ,TERF2
R-HSA-1614635	Sulfur amino acid metabolism	0.0169266987189638	-4.0788630977778	24	12	0.00527240773286467	2276	8202	58478,58472,6821,2729,84245,1468,2805,55748,4548,4507,1491,4552	ENOPH1,SQRDL,SUOX,GCLC,MRI1,SLC25A10,GOT1,CNDP2,MTR,MTAP,CTH,MTRR
R-HSA-73777	RNA Polymerase I Chain Elongation	0.0169515501263555	-4.07739599645491	88	34	0.0149384885764499	2276	8202	3015,5440,8367,6908,2071,25885,8350,8347,8360,8365,2968,8364,2965,653604,2068,3017,64425,8331,723790,902,85236,3021,8340,8363,8368,221830,11335,7343,8362,3012,51082,3014,5434,128312	H2AFZ,POLR2K,HIST1H4E,TBP,ERCC3,POLR1A,HIST1H3A,HIST1H2BC,HIST1H4D,HIST1H4H,GTF2H4,HIST1H4C,GTF2H1,HIST2H3D,ERCC2,HIST1H2BD,POLR1E,HIST1H2AJ,HIST2H2AA4,CCNH,HIST1H2BK,H3F3B,HIST1H2BL,HIST1H4J,HIST1H4L,TWISTNB,CBX3,UBTF,HIST1H4K,HIST1H2AE,POLR1D,H2AFX,POLR2E,HIST3H2BB
R-HSA-390450	Folding of actin by CCT/TriC	0.0170313969025738	-4.0726967616836	9	6	0.00263620386643234	2276	8202	7203,10576,6950,10574,10694,10575	CCT3,CCT2,TCP1,CCT7,CCT8,CCT4
R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	0.0174937990324138	-4.0459088018512	67	27	0.0118629173989455	2276	8202	4351,4597,10825,6480,79087,10020,79053,1798,26503,5373,91869,29926,4758,5372,10195,79947,6484,6675,79868,199857,57171,440138,29925,6483,85365,10559,144245	MPI,MVD,NEU3,ST6GAL1,ALG12,GNE,ALG8,DPAGT1,SLC17A5,PMM2,RFT1,GMPPA,NEU1,PMM1,ALG3,DHDDS,ST3GAL4,UAP1,ALG13,ALG14,DOLPP1,ALG11,GMPPB,ST3GAL2,ALG2,SLC35A1,ALG10B
R-HSA-168276	NS1 Mediated Effects on Host Pathways	0.0182665123447755	-4.00268582201068	38	17	0.00746924428822496	2276	8202	5903,4927,23511,3840,3841,55746,8480,53371,23636,9972,9631,8021,9818,23165,129401,8086,3837	RANBP2,NUP88,NUP188,KPNA4,KPNA5,NUP133,RAE1,NUP54,NUP62,NUP153,NUP155,NUP214,NUP58,NUP205,NUP35,AAAS,KPNB1
R-HSA-182971	EGFR downregulation	0.0189558109905189	-3.96564474588457	27	13	0.00571177504393673	2276	8202	7311,998,6233,2060,160,163,29924,7314,10253,1175,8027,30011,7316	UBA52,CDC42,RPS27A,EPS15,AP2A1,AP2B1,EPN1,UBB,SPRY2,AP2S1,STAM,SH3KBP1,UBC
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.0196265243366756	-3.93087334512367	14	8	0.00351493848857645	2276	8202	5529,5518,2932,5527,324,5526,1452,5528	PPP2R5E,PPP2R1A,GSK3B,PPP2R5C,APC,PPP2R5B,CSNK1A1,PPP2R5D
R-HSA-4839744	truncated APC mutants destabilize the destruction complex	0.0196265243366756	-3.93087334512367	14	8	0.00351493848857645	2276	8202	5529,5518,2932,5527,324,5526,1452,5528	PPP2R5E,PPP2R1A,GSK3B,PPP2R5C,APC,PPP2R5B,CSNK1A1,PPP2R5D
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.0196265243366756	-3.93087334512367	14	8	0.00351493848857645	2276	8202	5529,5518,2932,5527,324,5526,1452,5528	PPP2R5E,PPP2R1A,GSK3B,PPP2R5C,APC,PPP2R5B,CSNK1A1,PPP2R5D
R-HSA-4839735	AXIN mutants destabilize the destruction complex, activating WNT signaling	0.0196265243366756	-3.93087334512367	14	8	0.00351493848857645	2276	8202	5529,5518,2932,5527,324,5526,1452,5528	PPP2R5E,PPP2R1A,GSK3B,PPP2R5C,APC,PPP2R5B,CSNK1A1,PPP2R5D
R-HSA-204174	Regulation of pyruvate dehydrogenase (PDH) complex	0.0196265243366756	-3.93087334512367	14	8	0.00351493848857645	2276	8202	5160,57546,5467,5164,5163,54704,1738,5166	PDHA1,PDP2,PPARD,PDK2,PDK1,PDP1,DLD,PDK4
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.0196265243366756	-3.93087334512367	14	8	0.00351493848857645	2276	8202	5529,5518,2932,5527,324,5526,1452,5528	PPP2R5E,PPP2R1A,GSK3B,PPP2R5C,APC,PPP2R5B,CSNK1A1,PPP2R5D
R-HSA-4839748	AMER1 mutants destabilize the destruction complex	0.0196265243366756	-3.93087334512367	14	8	0.00351493848857645	2276	8202	5529,5518,2932,5527,324,5526,1452,5528	PPP2R5E,PPP2R1A,GSK3B,PPP2R5C,APC,PPP2R5B,CSNK1A1,PPP2R5D
R-HSA-2993913	Clearance of Nuclear Envelope Membranes from Chromatin	0.0204266558093097	-3.89091457374663	7	5	0.00219683655536028	2276	8202	2010,7443,23592,7444,7112	EMD,VRK1,LEMD3,VRK2,TMPO
R-HSA-5603029	IkBA variant leads to EDA-ID	0.0204266558093097	-3.89091457374663	7	5	0.00219683655536028	2276	8202	1147,8517,4791,5970,3551	CHUK,IKBKG,NFKB2,RELA,IKBKB
R-HSA-211000	Gene Silencing by RNA	0.0217028892701665	-3.83030988120826	130	47	0.0206502636203866	2276	8202	23112,3015,23511,5440,8367,8480,53371,8350,11022,8347,8360,23165,129401,8365,4927,55746,8364,653604,9972,3320,3017,5431,8331,723790,113802,7247,6895,85236,3021,9631,8340,8363,8368,8021,5430,5432,5903,3012,8362,201164,5434,3014,23636,128312,9818,8086,192669	TNRC6B,H2AFZ,NUP188,POLR2K,HIST1H4E,RAE1,NUP54,HIST1H3A,TDRKH,HIST1H2BC,HIST1H4D,NUP205,NUP35,HIST1H4H,NUP88,NUP133,HIST1H4C,HIST2H3D,NUP153,HSP90AA1,HIST1H2BD,POLR2B,HIST1H2AJ,HIST2H2AA4,HENMT1,TSN,TARBP2,HIST1H2BK,H3F3B,NUP155,HIST1H2BL,HIST1H4J,HIST1H4L,NUP214,POLR2A,POLR2C,RANBP2,HIST1H2AE,HIST1H4K,PLD6,POLR2E,H2AFX,NUP62,HIST3H2BB,NUP58,AAAS,AGO3
R-HSA-195721	Signaling by Wnt	0.0227332779717889	-3.78392543806235	326	107	0.04701230228471	2276	8202	3015,324,1488,8350,1460,5526,2535,2783,8658,8365,55737,805,5707,5696,5687,1499,5518,57680,8364,163,9070,59349,3017,2787,1856,8331,8321,7311,723790,208,1454,2788,85236,5695,23401,3021,857,8340,80319,5529,8362,7514,5719,8607,6233,5714,5709,59345,1213,3014,5527,2932,5690,5705,128312,9861,4343,5700,1175,5528,23112,5689,5693,8367,5713,90780,1452,5929,5715,9491,8347,8360,9559,4609,80326,4040,653604,51764,5717,6885,7314,5686,5694,7091,1455,5692,7090,607,5702,9101,5682,8363,5710,8368,5691,7316,6934,22943,3012,10023,160,7534,10197,81847,192669,8945,51699	H2AFZ,APC,CTBP2,HIST1H3A,CSNK2B,PPP2R5B,FZD2,GNB2,TNKS,HIST1H4H,VPS35,CALM2,PSMD1,PSMB8,PSMA6,CTNNB1,PPP2R1A,CHD8,HIST1H4C,AP2B1,ASH2L,KLHL12,HIST1H2BD,GNG5,DVL2,HIST1H2AJ,FZD1,UBA52,HIST2H2AA4,AKT2,CSNK1E,GNG7,HIST1H2BK,PSMB7,FRAT2,H3F3B,CAV1,HIST1H2BL,CXXC4,PPP2R5E,HIST1H4K,XPO1,PSMD13,RUVBL1,RPS27A,PSMD8,PSMD3,GNB4,CLTC,H2AFX,PPP2R5C,GSK3B,PSMB2,PSMC5,HIST3H2BB,PSMD6,MOV10,PSMC1,AP2S1,PPP2R5D,TNRC6B,PSMB1,PSMB5,HIST1H4E,PSMD7,PYGO2,CSNK1A1,RBBP5,PSMD9,PSMF1,HIST1H2BC,HIST1H4D,VPS26A,MYC,WNT10A,LRP6,HIST2H3D,GNG13,PSMD11,MAP3K7,UBB,PSMA5,PSMB6,TLE4,CSNK1G2,PSMB4,TLE3,BCL9,PSMC3,USP8,PSMA1,HIST1H4J,PSMD4,HIST1H4L,PSMB3,UBC,TCF7L2,DKK1,HIST1H2AE,FRAT1,AP2A1,YWHAZ,PSME3,RNF146,AGO3,BTRC,VPS29
R-HSA-157881	Cyclin B2 mediated events	0.0230299097403931	-3.77096148437593	5	4	0.00175746924428822	2276	8202	993,995,9133,983	CDC25A,CDC25C,CCNB2,CDK1
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	0.0234619665431409	-3.75237461390163	198	68	0.0298769771528998	2276	8202	23291,2475,1147,30011,805,5707,5696,5687,6464,6786,3551,5296,1027,8503,253260,10768,5970,64223,7311,2931,4690,208,842,5695,868,572,8517,5719,6233,5714,5709,2932,5690,5705,9861,4343,5700,5689,23112,5693,5966,5713,84335,23239,5715,9491,5781,145957,5717,2065,7314,6885,5686,5694,6199,5170,5692,3164,5702,10892,5682,3845,5710,7316,5691,10197,192669,8945	FBXW11,MTOR,CHUK,SH3KBP1,CALM2,PSMD1,PSMB8,PSMA6,SHC1,STIM1,IKBKB,PIK3R2,CDKN1B,PIK3R3,RICTOR,AHCYL1,RELA,MLST8,UBA52,GSK3A,NCK1,AKT2,CASP9,PSMB7,CBLB,BAD,IKBKG,PSMD13,RPS27A,PSMD8,PSMD3,GSK3B,PSMB2,PSMC5,PSMD6,MOV10,PSMC1,PSMB1,TNRC6B,PSMB5,REL,PSMD7,AKT1S1,PHLPP1,PSMD9,PSMF1,PTPN11,NRG4,PSMD11,ERBB3,UBB,MAP3K7,PSMA5,PSMB6,RPS6KB2,PDPK1,PSMB4,NR4A1,PSMC3,MALT1,PSMA1,KRAS,PSMD4,UBC,PSMB3,PSME3,AGO3,BTRC
R-HSA-1280218	Adaptive Immune System	0.0238453603428123	-3.73616561546472	668	208	0.0913884007029877	2276	8202	23291,9820,6890,55585,11004,9867,30011,805,5707,5696,998,6786,10193,51343,5296,10393,51619,8907,1785,54778,163,23295,3835,10411,26259,64223,140739,7311,4690,208,842,3309,868,3109,7335,1525,572,5719,6233,5714,7174,1213,3688,7320,5690,5527,2932,51130,5705,5528,5700,3122,7323,11258,51433,5689,10120,5693,9871,23480,3133,3134,26272,4012,140462,5713,3831,23327,29127,80196,84516,23239,5715,811,7408,8139,3107,54926,90678,5686,5058,10112,25847,5702,11069,10892,5682,3845,6921,4591,5691,10425,22872,24137,996,160,51626,7534,27338,9604,192669,90933,7317,84231,2475,55284,8655,5894,23304,1147,5526,162,821,5566,5687,6464,8651,5518,197131,3551,79876,1027,8503,253260,51434,64219,10768,5970,1639,10802,10484,79465,8767,2931,7879,991,5695,8697,23352,56658,3796,3108,8517,5529,7336,5709,23608,10533,9861,4343,1175,7334,55521,1781,6396,23112,9320,9903,25831,5966,10540,567,84335,9354,9491,4734,3105,27252,9632,51164,51465,5781,6047,26046,145957,5717,89910,2065,6885,7314,9730,5694,6199,80329,5170,5692,3164,6502,7319,7328,29882,5710,3832,55236,7316,51128,10671,8453,7322,51444,51752,23376,1062,10197,164,11065,8945,63891	FBXW11,CUL7,TAP1,UBE2Q1,KIF2C,PJA2,SH3KBP1,CALM2,PSMD1,PSMB8,CDC42,STIM1,RNF41,FZR1,PIK3R2,ANAPC10,UBE2D4,AP1M1,DNM2,RNF111,AP2B1,MGRN1,KIF22,RAPGEF3,FBXW8,MLST8,UBE2F,UBA52,NCK1,AKT2,CASP9,HSPA5,CBLB,HLA-DMB,UBE2V1,CXADR,BAD,PSMD13,RPS27A,PSMD8,TPP2,CLTC,ITGB1,UBE2B,PSMB2,PPP2R5C,GSK3B,ASB3,PSMC5,PPP2R5D,PSMC1,HLA-DRA,UBE2D3,DCTN3,ANAPC5,PSMB1,ACTR1B,PSMB5,SEC24D,SEC61G,HLA-E,HLA-F,FBXO4,LNPEP,ASB9,PSMD7,KLC1,NEDD4L,RACGAP1,RNF34,DCTN5,PHLPP1,PSMD9,CALR,VASP,GAN,HLA-C,UBE2R2,LRSAM1,PSMA5,PAK1,KIF20A,ANAPC13,PSMC3,RAPGEF4,MALT1,PSMA1,KRAS,TCEB1,TRIM37,PSMB3,ARIH2,SEC31A,KIF4A,CDC27,AP2A1,DYNC2LI1,YWHAZ,UBE2S,RNF14,AGO3,TRIM41,UBA1,TRAF7,MTOR,UBE2W,DYNLL1,RAF1,UBR2,CHUK,PPP2R5B,AP1B1,CANX,PRKACA,PSMA6,SHC1,SOCS1,PPP2R1A,UBR1,IKBKB,UBA5,CDKN1B,PIK3R3,RICTOR,ANAPC7,PJA1,AHCYL1,RELA,DCTN1,SEC24A,SEC23A,ULBP3,RIPK2,GSK3A,RAB7A,CDC20,PSMB7,CDC23,UBR4,TRIM39,KIF2A,HLA-DMA,IKBKG,PPP2R5E,UBE2V2,PSMD3,MKRN1,ATG7,PSMD6,MOV10,AP2S1,UBE2N,TRIM36,DYNC1I2,SEC13,TNRC6B,TRIP12,KLHL21,HECTD1,REL,DCTN2,B2M,AKT1S1,UBE4A,PSMF1,NEDD4,HLA-A,KLHL20,SEC24C,DCTN4,UBE2J1,PTPN11,RNF4,LTN1,NRG4,PSMD11,UBE3B,ERBB3,MAP3K7,UBB,VPRBP,PSMB6,RPS6KB2,ULBP1,PDPK1,PSMB4,NR4A1,SKP2,UBE2A,UBE2H,ANAPC2,PSMD4,KIF11,UBA6,UBC,SAR1B,DCTN6,CUL2,UBE2D2,RNF138,ERAP1,UFL1,CENPE,PSME3,AP1G1,UBE2C,BTRC,RNF123
R-HSA-1500620	Meiosis	0.0242817185395752	-3.71803153524723	115	42	0.0184534270650264	2276	8202	3015,8367,56158,8350,4292,641,7329,8347,8360,4000,8365,54386,6118,65057,4001,8364,26277,653604,545,4438,3017,8331,7014,723790,10274,1019,256126,29893,7156,85236,4439,3021,8340,8363,8368,5889,3012,675,8362,8243,3014,128312	H2AFZ,HIST1H4E,TEX12,HIST1H3A,MLH1,BLM,UBE2I,HIST1H2BC,HIST1H4D,LMNA,HIST1H4H,TERF2IP,RPA2,ACD,LMNB1,HIST1H4C,TINF2,HIST2H3D,ATR,MSH4,HIST1H2BD,HIST1H2AJ,TERF2,HIST2H2AA4,STAG1,CDK4,SYCE2,PSMC3IP,TOP3A,HIST1H2BK,MSH5,H3F3B,HIST1H2BL,HIST1H4J,HIST1H4L,RAD51C,HIST1H2AE,BRCA2,HIST1H4K,SMC1A,H2AFX,HIST3H2BB
R-HSA-2262749	Cellular response to hypoxia	0.0244917070629003	-3.70942070595975	25	12	0.00527240773286467	2276	8202	7323,7311,112398,6233,8453,7322,55662,6921,7314,112399,405,7316	UBE2D3,UBA52,EGLN2,RPS27A,CUL2,UBE2D2,HIF1AN,TCEB1,UBB,EGLN3,ARNT,UBC
R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen	0.0244917070629003	-3.70942070595975	25	12	0.00527240773286467	2276	8202	7323,7311,112398,6233,8453,7322,55662,6921,7314,112399,405,7316	UBE2D3,UBA52,EGLN2,RPS27A,CUL2,UBE2D2,HIF1AN,TCEB1,UBB,EGLN3,ARNT,UBC
R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	0.0245170843027086	-3.70838508596712	17	9	0.00395430579964851	2276	8202	23404,118460,23016,11340,55802,5393,54512,54464,167227	EXOSC2,EXOSC6,EXOSC7,EXOSC8,DCP1A,EXOSC9,EXOSC4,XRN1,DCP2
R-HSA-450604	KSRP (KHSRP) binds and destabilizes mRNA	0.0245170843027086	-3.70838508596712	17	9	0.00395430579964851	2276	8202	23404,118460,23016,11340,8570,7534,5393,54512,167227	EXOSC2,EXOSC6,EXOSC7,EXOSC8,KHSRP,YWHAZ,EXOSC9,EXOSC4,DCP2
R-HSA-69205	G1/S-Specific Transcription	0.0245170843027086	-3.70838508596712	17	9	0.00395430579964851	2276	8202	8318,993,5111,5422,6241,990,4998,983,26271	CDC45,CDC25A,PCNA,POLA1,RRM2,CDC6,ORC1,CDK1,FBXO5
R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	0.0245170843027086	-3.70838508596712	17	9	0.00395430579964851	2276	8202	23404,118460,23016,11340,55802,5393,54512,54464,167227	EXOSC2,EXOSC6,EXOSC7,EXOSC8,DCP1A,EXOSC9,EXOSC4,XRN1,DCP2
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.0249489457562282	-3.69092371193674	42	18	0.00790861159929701	2276	8202	7091,7311,208,7090,607,324,90780,5929,7316,6934,7514,1499,6233,57680,7534,9070,7314,8945	TLE4,UBA52,AKT2,TLE3,BCL9,APC,PYGO2,RBBP5,UBC,TCF7L2,XPO1,CTNNB1,RPS27A,CHD8,YWHAZ,ASH2L,UBB,BTRC
R-HSA-1221632	Meiotic synapsis	0.0257922040556282	-3.65768300110313	75	29	0.0127416520210896	2276	8202	3015,10274,723790,8367,256126,85236,56158,8363,8340,8368,7329,8347,8360,4000,8365,54386,3012,8362,65057,4001,8364,26277,8243,3014,545,128312,3017,8331,7014	H2AFZ,STAG1,HIST2H2AA4,HIST1H4E,SYCE2,HIST1H2BK,TEX12,HIST1H4J,HIST1H2BL,HIST1H4L,UBE2I,HIST1H2BC,HIST1H4D,LMNA,HIST1H4H,TERF2IP,HIST1H2AE,HIST1H4K,ACD,LMNB1,HIST1H4C,TINF2,SMC1A,H2AFX,ATR,HIST3H2BB,HIST1H2BD,HIST1H2AJ,TERF2
R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.0260418403102025	-3.64805079170414	72	28	0.0123022847100176	2276	8202	7323,1030,7050,7311,1024,1875,4092,23327,50848,8239,7316,51592,6498,7514,5933,6233,9110,51377,23645,4609,3726,5500,54778,5494,7314,11171,9958,6667	UBE2D3,CDKN2B,TGIF1,UBA52,CDK8,E2F5,SMAD7,NEDD4L,F11R,USP9X,UBC,TRIM33,SKIL,XPO1,RBL1,RPS27A,MTMR4,UCHL5,PPP1R15A,MYC,JUNB,PPP1CB,RNF111,PPM1A,UBB,STRAP,USP15,SP1
R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)	0.0265850650317063	-3.62740568584841	28	13	0.00571177504393673	2276	8202	27243,7311,6233,51534,79720,9525,7251,11267,7314,25978,51652,8027,7316	CHMP2A,UBA52,RPS27A,VTA1,VPS37B,VPS4B,TSG101,SNF8,UBB,CHMP2B,CHMP3,STAM,UBC
R-HSA-380972	Energy dependent regulation of mTOR by LKB1-AMPK	0.0265850650317063	-3.62740568584841	28	13	0.00571177504393673	2276	8202	7248,5564,51422,2475,5565,5562,389541,28956,5571,81617,5494,6009,64223	TSC1,PRKAB1,PRKAG2,MTOR,PRKAB2,PRKAA1,LAMTOR4,LAMTOR2,PRKAG1,CAB39L,PPM1A,RHEB,MLST8
R-HSA-73772	RNA Polymerase I Promoter Escape	0.0282765806065591	-3.5657213573378	31	14	0.00615114235500879	2276	8202	7343,54700,902,2968,5440,51082,6908,2071,25885,5434,2965,2068,64425,221830	UBTF,RRN3,CCNH,GTF2H4,POLR2K,POLR1D,TBP,ERCC3,POLR1A,POLR2E,GTF2H1,ERCC2,POLR1E,TWISTNB
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.0282765806065591	-3.5657213573378	31	14	0.00615114235500879	2276	8202	1030,7050,7311,1024,5933,6233,4609,1875,3726,4092,54778,7314,7316,6667	CDKN2B,TGIF1,UBA52,CDK8,RBL1,RPS27A,MYC,E2F5,JUNB,SMAD7,RNF111,UBB,UBC,SP1
R-HSA-176033	Interactions of Vpr with host cellular proteins	0.0296230325906297	-3.51920309217499	34	15	0.00659050966608084	2276	8202	5903,4927,23511,55746,8480,53371,23636,9972,9631,3159,8021,9818,23165,129401,8086	RANBP2,NUP88,NUP188,NUP133,RAE1,NUP54,NUP62,NUP153,NUP155,HMGA1,NUP214,NUP58,NUP205,NUP35,AAAS
R-HSA-168253	Host Interactions with Influenza Factors	0.0314759970989106	-3.4585300204777	40	17	0.00746924428822496	2276	8202	5903,4927,23511,3840,3841,55746,8480,53371,23636,9972,9631,8021,9818,23165,129401,8086,3837	RANBP2,NUP88,NUP188,KPNA4,KPNA5,NUP133,RAE1,NUP54,NUP62,NUP153,NUP155,NUP214,NUP58,NUP205,NUP35,AAAS,KPNB1
R-HSA-70895	Branched-chain amino acid catabolism	0.0317218844629134	-3.45074847468276	23	11	0.00483304042179262	2276	8202	10295,6470,4329,594,593,56922,1738,1629,152926,64087,11112	BCKDK,SHMT1,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,PPM1K,MCCC2,HIBADH
R-HSA-5627123	RHO GTPases activate PAKs	0.0317218844629134	-3.45074847468276	23	11	0.00483304042179262	2276	8202	805,5058,4659,4771,998,5500,4660,4627,4637,2017,4628	CALM2,PAK1,PPP1R12A,NF2,CDC42,PPP1CB,PPP1R12B,MYH9,MYL6,CTTN,MYH10
R-HSA-421837	Clathrin derived vesicle budding	0.031738405303657	-3.45022780762695	70	27	0.0118629173989455	2276	8202	27243,2512,6272,54885,3312,1777,25977,7163,9179,162,26258,6810,7164,9685,8729,8301,7037,2647,4074,1213,8907,1785,2580,164,5878,27131,23557	CHMP2A,FTL,SORT1,TBC1D8B,HSPA8,DNASE2,NECAP1,TPD52,AP4M1,AP1B1,BLOC1S6,STX4,TPD52L1,CLINT1,GBF1,PICALM,TFRC,BLOC1S1,M6PR,CLTC,AP1M1,DNM2,GAK,AP1G1,RAB5C,SNX5,SNAPIN
R-HSA-199992	trans-Golgi Network Vesicle Budding	0.031738405303657	-3.45022780762695	70	27	0.0118629173989455	2276	8202	27243,2512,6272,54885,3312,1777,25977,7163,9179,162,26258,6810,7164,9685,8729,8301,7037,2647,4074,1213,8907,1785,2580,164,5878,27131,23557	CHMP2A,FTL,SORT1,TBC1D8B,HSPA8,DNASE2,NECAP1,TPD52,AP4M1,AP1B1,BLOC1S6,STX4,TPD52L1,CLINT1,GBF1,PICALM,TFRC,BLOC1S1,M6PR,CLTC,AP1M1,DNM2,GAK,AP1G1,RAB5C,SNX5,SNAPIN
R-HSA-4419969	Depolymerisation of the Nuclear Lamina	0.0319898451907147	-3.44233676433487	15	8	0.00351493848857645	2276	8202	2010,4001,23592,64900,983,255919,4000,7112	EMD,LMNB1,LEMD3,LPIN3,CDK1,CNEP1R1,LMNA,TMPO
R-HSA-975144	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	0.0326748404279611	-3.42114990309629	10	6	0.00263620386643234	2276	8202	1147,7335,8517,246330,7334,3551	CHUK,UBE2V1,IKBKG,PELI3,UBE2N,IKBKB
R-HSA-937039	IRAK1 recruits IKK complex	0.0326748404279611	-3.42114990309629	10	6	0.00263620386643234	2276	8202	1147,7335,8517,246330,7334,3551	CHUK,UBE2V1,IKBKG,PELI3,UBE2N,IKBKB
R-HSA-110056	MAPK3 (ERK1) activation	0.0326748404279611	-3.42114990309629	10	6	0.00263620386643234	2276	8202	3717,7297,983,3569,5781,5604	JAK2,TYK2,CDK1,IL6,PTPN11,MAP2K1
R-HSA-5663202	Diseases of signal transduction	0.0358133340027668	-3.32943499674297	268	88	0.0386643233743409	2276	8202	142678,8805,2475,1147,324,6777,1488,5526,10013,8658,5696,5687,5707,6464,1499,5518,5296,8503,1027,253260,11052,11140,64223,7311,2931,51107,208,842,5695,10014,7415,572,5529,9759,5719,6233,5714,5709,6400,6772,5690,5527,2932,9861,5705,5528,5700,23385,3066,5689,5693,5713,84335,5715,1452,9491,4609,5781,4040,5717,145957,3320,2065,7314,9794,6774,5686,6199,5694,5170,3280,6868,1024,5692,3164,5702,5682,3845,84447,5710,222236,7316,6934,5691,22943,6907,3516,10197	MIB2,TRIM24,MTOR,CHUK,APC,STAT5B,CTBP2,PPP2R5B,HDAC6,TNKS,PSMB8,PSMA6,PSMD1,SHC1,CTNNB1,PPP2R1A,PIK3R2,PIK3R3,CDKN1B,RICTOR,CPSF6,CDC37,MLST8,UBA52,GSK3A,APH1A,AKT2,CASP9,PSMB7,HDAC5,VCP,BAD,PPP2R5E,HDAC4,PSMD13,RPS27A,PSMD8,PSMD3,SEL1L,STAT1,PSMB2,PPP2R5C,GSK3B,PSMD6,PSMC5,PPP2R5D,PSMC1,NCSTN,HDAC2,PSMB1,PSMB5,PSMD7,AKT1S1,PSMD9,CSNK1A1,PSMF1,MYC,PTPN11,LRP6,PSMD11,NRG4,HSP90AA1,ERBB3,UBB,MAML1,STAT3,PSMA5,RPS6KB2,PSMB6,PDPK1,HES1,ADAM17,CDK8,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,SYVN1,PSMD4,NAPEPLD,UBC,TCF7L2,PSMB3,DKK1,TBL1X,RBPJ,PSME3
R-HSA-73780	RNA Polymerase III Chain Elongation	0.0372001416591128	-3.29144270966962	18	9	0.00395430579964851	2276	8202	661,5440,51082,171568,5434,55703,51728,11128,10621	POLR3D,POLR2K,POLR1D,POLR3H,POLR2E,POLR3B,POLR3K,POLR3A,POLR3F
R-HSA-3296482	Defects in vitamin and cofactor metabolism	0.0372001416591128	-3.29144270966962	18	9	0.00395430579964851	2276	8202	25974,4594,5091,56922,27249,4548,64087,51293,4552	MMACHC,MUT,PC,MCCC1,MMADHC,MTR,MCCC2,CD320,MTRR
R-HSA-2299718	Condensation of Prophase Chromosomes	0.0380518908727938	-3.2688045014862	71	27	0.0118629173989455	2276	8202	3015,723790,8367,23133,85236,8350,3021,8363,8340,8368,983,8347,8360,8365,3012,8362,23310,387893,8364,3014,653604,29781,128312,54892,3017,8331,10051	H2AFZ,HIST2H2AA4,HIST1H4E,PHF8,HIST1H2BK,HIST1H3A,H3F3B,HIST1H4J,HIST1H2BL,HIST1H4L,CDK1,HIST1H2BC,HIST1H4D,HIST1H4H,HIST1H2AE,HIST1H4K,NCAPD3,KMT5A,HIST1H4C,H2AFX,HIST2H3D,NCAPH2,HIST3H2BB,NCAPG2,HIST1H2BD,HIST1H2AJ,SMC4
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	0.0381604632773402	-3.26595529208423	115	41	0.0180140597539543	2276	8202	27242,10001,54797,25942,29079,55090,3157,112950,84246,9441,4520,1490,6721,9862,9443,27063,9572,90390,2222,6667,3156,7296,23309,3992,9439,1024,7003,9442,2274,10025,8202,23097,51,406,51586,4802,9282,6907,10891,2101,9575	TNFRSF21,MED6,MED18,SIN3A,MED4,MED9,HMGCS1,MED8,MED10,MED26,MTF1,CTGF,SREBF2,MED24,MED7,ANKRD1,NR1D1,MED30,FDFT1,SP1,HMGCR,TXNRD1,SIN3B,FADS1,MED23,CDK8,TEAD1,MED27,FHL2,MED16,NCOA3,CDK19,ACOX1,ARNTL,MED15,NFYC,MED14,TBL1X,PPARGC1A,ESRRA,CLOCK
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	0.0402468191447497	-3.21272430570003	41	17	0.00746924428822496	2276	8202	1595,3422,3157,4520,6721,4597,2224,4802,6907,57678,1717,6309,10654,9453,2222,6667,3156	CYP51A1,IDI1,HMGCS1,MTF1,SREBF2,MVD,FDPS,NFYC,TBL1X,GPAM,DHCR7,SC5D,PMVK,GGPS1,FDFT1,SP1,HMGCR
R-HSA-70153	Glucose transport	0.0402468191447497	-3.21272430570003	41	17	0.00746924428822496	2276	8202	6517,23511,8480,53371,9631,92579,8021,23165,129401,5903,4927,2542,55746,23636,9972,9818,8086	SLC2A4,NUP188,RAE1,NUP54,NUP155,G6PC3,NUP214,NUP205,NUP35,RANBP2,NUP88,SLC37A4,NUP133,NUP62,NUP153,NUP58,AAAS
R-HSA-379726	Mitochondrial tRNA aminoacylation	0.0412047726601364	-3.18920118807029	21	10	0.00439367311072056	2276	8202	79731,124454,2617,57505,27068,10667,23438,80222,54938,79587	NARS2,EARS2,GARS,AARS2,PPA2,FARS2,HARS2,TARS2,SARS2,CARS2
R-HSA-209560	NF-kB is activated and signals survival	0.0419339000867912	-3.17166070789199	13	7	0.00307557117750439	2276	8202	7311,8878,7314,5970,6233,7316,3551	UBA52,SQSTM1,UBB,RELA,RPS27A,UBC,IKBKB
R-HSA-2564830	Cytosolic iron-sulfur cluster assembly	0.0419339000867912	-3.17166070789199	13	7	0.00307557117750439	2276	8202	27158,51647,2068,83990,5424,4682,10101	NDOR1,FAM96B,ERCC2,BRIP1,POLD1,NUBP1,NUBP2
R-HSA-175474	Assembly Of The HIV Virion	0.0419339000867912	-3.17166070789199	13	7	0.00307557117750439	2276	8202	7251,7311,7314,6233,79720,5478,7316	TSG101,UBA52,UBB,RPS27A,VPS37B,PPIA,UBC
R-HSA-1253288	Downregulation of ERBB4 signaling	0.042114176452226	-3.16737086214361	8	5	0.00219683655536028	2276	8202	7311,7314,6233,7316,4734	UBA52,UBB,RPS27A,UBC,NEDD4
R-HSA-5603027	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	0.042114176452226	-3.16737086214361	8	5	0.00219683655536028	2276	8202	1147,8517,4791,5970,3551	CHUK,IKBKG,NFKB2,RELA,IKBKB
R-HSA-5358493	Synthesis of diphthamide-EEF2	0.042114176452226	-3.16737086214361	8	5	0.00219683655536028	2276	8202	89978,1938,1801,1802,285381	DPH6,EEF2,DPH1,DPH2,DPH3
R-HSA-913531	Interferon Signaling	0.0435735937586543	-3.13330395984311	194	65	0.0285588752196837	2276	8202	23511,85363,5495,55128,5696,8651,9775,55746,5300,3660,103,9972,3459,1977,25820,7311,3841,11274,9631,8021,7297,6773,3669,5903,817,6233,80263,6772,7334,8086,3122,1958,8480,3134,3133,53371,51191,8672,567,51447,129401,3105,23165,4734,7341,5770,4927,5781,10379,10612,3717,3107,7314,3837,4502,1974,1973,23087,1982,7316,7726,3840,23636,9818,2537	NUP188,TRIM5,PPM1B,TRIM68,PSMB8,SOCS1,EIF4A3,NUP133,PIN1,IRF2,ADAR,NUP153,IFNGR1,EIF4E,ARIH1,UBA52,KPNA5,USP18,NUP155,NUP214,TYK2,STAT2,ISG20,RANBP2,CAMK2D,RPS27A,TRIM45,STAT1,UBE2N,AAAS,HLA-DRA,EGR1,RAE1,HLA-F,HLA-E,NUP54,HERC5,EIF4G3,B2M,IP6K2,NUP35,HLA-A,NUP205,NEDD4,SUMO1,PTPN1,NUP88,PTPN11,IRF9,TRIM3,JAK2,HLA-C,UBB,KPNB1,MT2A,EIF4A2,EIF4A1,TRIM35,EIF4G2,UBC,TRIM26,KPNA4,NUP62,NUP58,IFI6
R-HSA-379716	Cytosolic tRNA aminoacylation	0.0442408877842178	-3.11810585451421	24	11	0.00483304042179262	2276	8202	2193,5917,2058,51520,2617,3376,10056,7965,16,9521,7453	FARSA,RARS,EPRS,LARS,GARS,IARS,FARSB,AIMP2,AARS,EEF1E1,WARS
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	0.0481496543450074	-3.03344131947597	30	13	0.00571177504393673	2276	8202	3725,466,6196,1848,5518,5601,4205,5598,2002,9252,2353,1386,5528	JUN,ATF1,RPS6KA2,DUSP6,PPP2R1A,MAPK9,MEF2A,MAPK7,ELK1,RPS6KA5,FOS,ATF2,PPP2R5D
R-HSA-1295596	Spry regulation of FGF signaling	0.0487493028981425	-3.0210643811658	16	8	0.00351493848857645	2276	8202	7311,673,7314,5518,6233,10253,7316,5781	UBA52,BRAF,UBB,PPP2R1A,RPS27A,SPRY2,UBC,PTPN11
R-HSA-5625900	RHO GTPases activate CIT	0.0487493028981425	-3.0210643811658	16	8	0.00351493848857645	2276	8202	11113,9928,9055,1027,4637,4627,1742,4628	CIT,KIF14,PRC1,CDKN1B,MYL6,MYH9,DLG4,MYH10
R-HSA-432722	Golgi Associated Vesicle Biogenesis	0.0495505009947273	-3.00476290736468	54	21	0.00922671353251318	2276	8202	2512,6272,54885,3312,25977,7163,162,26258,7164,9685,8301,7037,2647,1213,1785,8907,2580,164,5878,27131,23557	FTL,SORT1,TBC1D8B,HSPA8,NECAP1,TPD52,AP1B1,BLOC1S6,TPD52L1,CLINT1,PICALM,TFRC,BLOC1S1,CLTC,DNM2,AP1M1,GAK,AP1G1,RAB5C,SNX5,SNAPIN
R-HSA-383280	Nuclear Receptor transcription pathway	0.0500258319618145	-2.9952157677298	51	20	0.00878734622144113	2276	8202	5915,5914,2649,2908,29982,3164,10062,2100,7376,7025,6257,7421,5467,8013,4929,2101,9572,4306,7181,29959	RARB,RARA,NR6A1,NR3C1,NRBF2,NR4A1,NR1H3,ESR2,NR1H2,NR2F1,RXRB,VDR,PPARD,NR4A3,NR4A2,ESRRA,NR1D1,NR3C2,NR2C1,NRBP1
R-HSA-1592230	Mitochondrial biogenesis	0.0500258319618145	-2.9952157677298	51	20	0.00878734622144113	2276	8202	3054,5564,64216,7978,2551,5565,5571,54205,4209,506,11232,2553,51422,6907,23082,6742,10891,2101,1386,9572	HCFC1,PRKAB1,TFB2M,MTERF1,GABPA,PRKAB2,PRKAG1,CYCS,MEF2D,ATP5B,POLG2,GABPB1,PRKAG2,TBL1X,PPRC1,SSBP1,PPARGC1A,ESRRA,ATF2,NR1D1
R-HSA-3214842	HDMs demethylate histones	0.0503858457965607	-2.98804498071684	48	19	0.00834797891036907	2276	8202	7403,9682,8367,5927,23133,84159,23210,8350,8363,8368,55818,8360,23028,8365,8362,23030,8364,653604,23081	KDM6A,KDM4A,HIST1H4E,KDM5A,PHF8,ARID5B,JMJD6,HIST1H3A,HIST1H4J,HIST1H4L,KDM3A,HIST1H4D,KDM1A,HIST1H4H,HIST1H4K,KDM4B,HIST1H4C,HIST2H3D,KDM4C
R-HSA-5668914	Diseases of metabolism	0.0506043612527831	-2.98371751563646	45	18	0.00790861159929701	2276	8202	25974,7311,4594,56922,27249,7270,4548,51293,7316,4552,5091,112812,6233,2232,2997,7314,29080,64087	MMACHC,UBA52,MUT,MCCC1,MMADHC,TTF1,MTR,CD320,UBC,MTRR,PC,FDX1L,RPS27A,FDXR,GYS1,UBB,CCDC59,MCCC2
R-HSA-5336415	Uptake and function of diphtheria toxin	0.0539520390464443	-2.91965979287739	6	4	0.00175746924428822	2276	8202	7296,3320,1938,3326	TXNRD1,HSP90AA1,EEF2,HSP90AB1
R-HSA-176417	Phosphorylation of Emi1	0.0539520390464443	-2.91965979287739	6	4	0.00175746924428822	2276	8202	983,51343,991,26271	CDK1,FZR1,CDC20,FBXO5
R-HSA-1237112	Methionine salvage pathway	0.0539520390464443	-2.91965979287739	6	4	0.00175746924428822	2276	8202	58478,2805,84245,4507	ENOPH1,GOT1,MRI1,MTAP
R-HSA-3000484	Scavenging by Class F Receptors	0.0539520390464443	-2.91965979287739	6	4	0.00175746924428822	2276	8202	10525,811,10808,3320	HYOU1,CALR,HSPH1,HSP90AA1
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	0.0552921432985795	-2.89512445471407	11	6	0.00263620386643234	2276	8202	4926,121441,983,10426,10844,85378	NUMA1,NEDD1,CDK1,TUBGCP3,TUBGCP2,TUBGCP6
R-HSA-1059683	Interleukin-6 signaling	0.0552921432985795	-2.89512445471407	11	6	0.00263620386643234	2276	8202	3717,6774,3569,7297,6772,5781	JAK2,STAT3,IL6,TYK2,STAT1,PTPN11
R-HSA-174490	Membrane binding and targetting of GAG proteins	0.0552921432985795	-2.89512445471407	11	6	0.00263620386643234	2276	8202	7251,7311,7314,6233,79720,7316	TSG101,UBA52,UBB,RPS27A,VPS37B,UBC
R-HSA-3296469	Defects in cobalamin (B12) metabolism	0.0552921432985795	-2.89512445471407	11	6	0.00263620386643234	2276	8202	25974,4594,4548,51293,4552,27249	MMACHC,MUT,MTR,CD320,MTRR,MMADHC
R-HSA-174495	Synthesis And Processing Of GAG, GAGPOL Polyproteins	0.0552921432985795	-2.89512445471407	11	6	0.00263620386643234	2276	8202	7251,7311,7314,6233,79720,7316	TSG101,UBA52,UBB,RPS27A,VPS37B,UBC
R-HSA-1236977	Endosomal/Vacuolar pathway	0.0552921432985795	-2.89512445471407	11	6	0.00263620386643234	2276	8202	567,3107,3133,3134,3105,4012	B2M,HLA-C,HLA-E,HLA-F,HLA-A,LNPEP
R-HSA-2514853	Condensation of Prometaphase Chromosomes	0.0552921432985795	-2.89512445471407	11	6	0.00263620386643234	2276	8202	9918,1460,64151,9133,983,10051	NCAPD2,CSNK2B,NCAPG,CCNB2,CDK1,SMC4
R-HSA-77588	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	0.0552921432985795	-2.89512445471407	11	6	0.00263620386643234	2276	8202	7884,6635,6637,25888,4686,84967	SLBP,SNRPE,SNRPG,ZNF473,NCBP1,LSM10
R-HSA-203765	eNOS activation and regulation	0.0572621597260871	-2.86011526213861	22	10	0.00439367311072056	2276	8202	805,23564,2644,8976,1785,5805,10434,857,3320,51070	CALM2,DDAH2,GCHFR,WASL,DNM2,PTS,LYPLA1,CAV1,HSP90AA1,NOSIP
R-HSA-3371571	HSF1-dependent transactivation	0.0572621597260871	-2.86011526213861	22	10	0.00439367311072056	2276	8202	817,2475,3326,3312,3320,10728,3337,84335,3304,64223	CAMK2D,MTOR,HSP90AB1,HSPA8,HSP90AA1,PTGES3,DNAJB1,AKT1S1,HSPA1B,MLST8
R-HSA-166208	mTORC1-mediated signalling	0.0572621597260871	-2.86011526213861	22	10	0.00439367311072056	2276	8202	1975,2475,389541,28956,6194,6198,84335,1977,6009,64223	EIF4B,MTOR,LAMTOR4,LAMTOR2,RPS6,RPS6KB1,AKT1S1,EIF4E,RHEB,MLST8
R-HSA-202131	Metabolism of nitric oxide	0.0572621597260871	-2.86011526213861	22	10	0.00439367311072056	2276	8202	805,23564,2644,8976,1785,5805,10434,857,3320,51070	CALM2,DDAH2,GCHFR,WASL,DNM2,PTS,LYPLA1,CAV1,HSP90AA1,NOSIP
R-HSA-1989781	PPARA activates gene expression	0.059701507461294	-2.81839800829443	112	39	0.0171353251318102	2276	8202	27242,10001,54797,29079,55090,3157,112950,84246,9441,4520,1490,6721,9862,9443,27063,9572,90390,2222,6667,3156,7296,3992,9439,1024,7003,9442,2274,10025,8202,23097,51,406,51586,4802,9282,6907,10891,2101,9575	TNFRSF21,MED6,MED18,MED4,MED9,HMGCS1,MED8,MED10,MED26,MTF1,CTGF,SREBF2,MED24,MED7,ANKRD1,NR1D1,MED30,FDFT1,SP1,HMGCR,TXNRD1,FADS1,MED23,CDK8,TEAD1,MED27,FHL2,MED16,NCOA3,CDK19,ACOX1,ARNTL,MED15,NFYC,MED14,TBL1X,PPARGC1A,ESRRA,CLOCK
R-HSA-114452	Activation of BH3-only proteins	0.0597581012100205	-2.8174505122564	25	11	0.00483304042179262	2276	8202	572,90427,5366,208,8655,7157,10971,7534,7531,7533,7532	BAD,BMF,PMAIP1,AKT2,DYNLL1,TP53,YWHAQ,YWHAZ,YWHAE,YWHAH,YWHAG
R-HSA-1538133	G0 and Early G1	0.0597581012100205	-2.8174505122564	25	11	0.00483304042179262	2276	8202	132660,7153,993,5111,1859,890,5933,1875,990,983,55957	LIN54,TOP2A,CDC25A,PCNA,DYRK1A,CCNA2,RBL1,E2F5,CDC6,CDK1,LIN37
R-HSA-4791275	Signaling by WNT in cancer	0.0630742004037141	-2.76344346144834	34	14	0.00615114235500879	2276	8202	5529,1499,5518,2932,4040,5527,1488,324,5526,1452,8658,5528,6934,22943	PPP2R5E,CTNNB1,PPP2R1A,GSK3B,LRP6,PPP2R5C,CTBP2,APC,PPP2R5B,CSNK1A1,TNKS,PPP2R5D,TCF7L2,DKK1
R-HSA-196854	Metabolism of vitamins and cofactors	0.0636730389091238	-2.75399405703418	90	32	0.0140597539543058	2276	8202	27304,80025,55191,25974,4594,56922,27249,8884,10560,51293,4552,80308,60496,2356,326625,64087,55163,6470,55312,8034,55788,93100,4548,1528,27010,5743,119391,5091,200895,9054,686,65220	MOCS3,PANK2,NADSYN1,MMACHC,MUT,MCCC1,MMADHC,SLC5A6,SLC19A2,CD320,MTRR,FLAD1,AASDHPPT,FPGS,MMAB,MCCC2,PNPO,SHMT1,RFK,SLC25A16,LMBRD1,NAPRT,MTR,CYB5A,TPK1,PTGS2,GSTO2,PC,DHFRL1,NFS1,BTD,NADK
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	0.0636730389091238	-2.75399405703418	90	32	0.0140597539543058	2276	8202	27304,80025,55191,25974,4594,56922,27249,8884,10560,51293,4552,80308,60496,2356,326625,64087,55163,6470,55312,8034,55788,93100,4548,1528,27010,5743,119391,5091,200895,9054,686,65220	MOCS3,PANK2,NADSYN1,MMACHC,MUT,MCCC1,MMADHC,SLC5A6,SLC19A2,CD320,MTRR,FLAD1,AASDHPPT,FPGS,MMAB,MCCC2,PNPO,SHMT1,RFK,SLC25A16,LMBRD1,NAPRT,MTR,CYB5A,TPK1,PTGS2,GSTO2,PC,DHFRL1,NFS1,BTD,NADK
R-HSA-77595	Processing of Intronless Pre-mRNAs	0.0642412758357281	-2.74510934908431	14	7	0.00307557117750439	2276	8202	1478,51585,4686,11051,51692,10978,1477	CSTF2,PCF11,NCBP1,NUDT21,CPSF3,CLP1,CSTF1
R-HSA-877312	Regulation of IFNG signaling	0.0642412758357281	-2.74510934908431	14	7	0.00307557117750439	2276	8202	3717,5770,3459,8651,7341,6772,5781	JAK2,PTPN1,IFNGR1,SOCS1,SUMO1,STAT1,PTPN11
R-HSA-912446	Meiotic recombination	0.0672112762058131	-2.69991424484825	84	30	0.0131810193321617	2276	8202	3015,723790,8367,1019,29893,85236,7156,4439,8350,3021,4292,8363,8340,641,8368,8347,8360,8365,6118,5889,3012,8362,675,8364,3014,653604,4438,128312,3017,8331	H2AFZ,HIST2H2AA4,HIST1H4E,CDK4,PSMC3IP,HIST1H2BK,TOP3A,MSH5,HIST1H3A,H3F3B,MLH1,HIST1H4J,HIST1H2BL,BLM,HIST1H4L,HIST1H2BC,HIST1H4D,HIST1H4H,RPA2,RAD51C,HIST1H2AE,HIST1H4K,BRCA2,HIST1H4C,H2AFX,HIST2H3D,MSH4,HIST3H2BB,HIST1H2BD,HIST1H2AJ
R-HSA-168928	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	0.0690387758130887	-2.6730869639243	81	29	0.0127416520210896	2276	8202	55593,7323,3146,1540,7311,7128,79671,7186,8887,9140,51191,1147,80143,8772,7316,8517,6233,5300,3551,7322,3660,9474,7314,4791,64135,5970,170506,54476,5094	OTUD5,UBE2D3,HMGB1,CYLD,UBA52,TNFAIP3,NLRX1,TRAF2,TAX1BP1,ATG12,HERC5,CHUK,SIKE1,FADD,UBC,IKBKG,RPS27A,PIN1,IKBKB,UBE2D2,IRF2,ATG5,UBB,NFKB2,IFIH1,RELA,DHX36,RNF216,PCBP2
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	0.0702890527625525	-2.65513921401897	17	8	0.00351493848857645	2276	8202	8517,6885,8767,10454,257397,7867,5608,5606	IKBKG,MAP3K7,RIPK2,TAB1,TAB3,MAPKAPK3,MAP2K6,MAP2K3
R-HSA-176412	Phosphorylation of the APC/C	0.0702890527625525	-2.65513921401897	17	8	0.00351493848857645	2276	8202	29882,51433,51434,8697,996,11065,983,10393	ANAPC2,ANAPC5,ANAPC7,CDC23,CDC27,UBE2C,CDK1,ANAPC10
R-HSA-1362409	Mitochondrial iron-sulfur cluster biogenesis	0.073467650889179	-2.61091009360307	9	5	0.00219683655536028	2276	8202	81894,112812,9054,2232,51312	SLC25A28,FDX1L,NFS1,FDXR,SLC25A37
R-HSA-196108	Pregnenolone biosynthesis	0.073467650889179	-2.61091009360307	9	5	0.00219683655536028	2276	8202	231,112812,80765,2232,134429	AKR1B1,FDX1L,STARD5,FDXR,STARD4
R-HSA-112409	RAF-independent MAPK1/3 activation	0.0769085253137629	-2.56513854627769	23	10	0.00439367311072056	2276	8202	1848,3569,5781,5604,11221,3717,7297,1847,983,1843	DUSP6,IL6,PTPN11,MAP2K1,DUSP10,JAK2,TYK2,DUSP5,CDK1,DUSP1
R-HSA-168268	Virus Assembly and Release	0.0769780812785199	-2.56423455637196	2	2	0.000878734622144112	2276	8202	811,821	CALR,CANX
R-HSA-5652227	Fructose biosynthesis	0.0769780812785199	-2.56423455637196	2	2	0.000878734622144112	2276	8202	231,6652	AKR1B1,SORD
R-HSA-3359469	Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	0.0769780812785199	-2.56423455637196	2	2	0.000878734622144112	2276	8202	4548,4552	MTR,MTRR
R-HSA-141424	Amplification of signal from the kinetochores	0.0769780812785199	-2.56423455637196	2	2	0.000878734622144112	2276	8202	4085,8379	MAD2L1,MAD1L1
R-HSA-141444	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal	0.0769780812785199	-2.56423455637196	2	2	0.000878734622144112	2276	8202	4085,8379	MAD2L1,MAD1L1
R-HSA-111457	Release of apoptotic factors from the mitochondria	0.0769780812785199	-2.56423455637196	2	2	0.000878734622144112	2276	8202	56616,54205	DIABLO,CYCS
R-HSA-168316	Assembly of Viral Components at the Budding Site	0.0769780812785199	-2.56423455637196	2	2	0.000878734622144112	2276	8202	811,821	CALR,CANX
R-HSA-3359467	Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE	0.0769780812785199	-2.56423455637196	2	2	0.000878734622144112	2276	8202	4548,4552	MTR,MTRR
R-HSA-198765	Signalling to ERK5	0.0769780812785199	-2.56423455637196	2	2	0.000878734622144112	2276	8202	5607,5598	MAP2K5,MAPK7
R-HSA-70688	Proline catabolism	0.0769780812785199	-2.56423455637196	2	2	0.000878734622144112	2276	8202	8659,5625	ALDH4A1,PRODH
R-HSA-5602636	IKBKB deficiency causes SCID	0.0769780812785199	-2.56423455637196	2	2	0.000878734622144112	2276	8202	1147,8517	CHUK,IKBKG
R-HSA-3359473	Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD	0.0769780812785199	-2.56423455637196	2	2	0.000878734622144112	2276	8202	25974,27249	MMACHC,MMADHC
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	0.0792338101414953	-2.53535217552986	29	12	0.00527240773286467	2276	8202	10576,6950,26272,7203,26190,22803,10574,83752,10694,54461,10575,84261	CCT2,TCP1,FBXO4,CCT3,FBXW2,XRN2,CCT7,LONP2,CCT8,FBXW5,CCT4,FBXW9
R-HSA-5339562	Uptake and actions of bacterial toxins	0.0792338101414953	-2.53535217552986	29	12	0.00527240773286467	2276	8202	7296,805,1938,5609,6843,5608,3326,5604,6616,3320,84168,5606	TXNRD1,CALM2,EEF2,MAP2K7,VAMP1,MAP2K6,HSP90AB1,MAP2K1,SNAP25,HSP90AA1,ANTXR1,MAP2K3
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.0794344688247497	-2.53282288874949	32	13	0.00571177504393673	2276	8202	7311,7514,9110,6233,51377,23645,4092,5500,23327,7314,11171,7316,9958	UBA52,XPO1,MTMR4,RPS27A,UCHL5,PPP1R15A,SMAD7,PPP1CB,NEDD4L,UBB,STRAP,UBC,USP15
R-HSA-193704	p75 NTR receptor-mediated signalling	0.0794724476386801	-2.53234488797395	82	29	0.0127416520210896	2276	8202	10451,6868,7311,26574,8767,51107,1894,57142,23365,7531,7316,27237,572,8878,6233,27018,9138,3551,5584,835,9181,9828,7314,5970,23229,23385,6453,64857,3066	VAV3,ADAM17,UBA52,AATF,RIPK2,APH1A,ECT2,RTN4,ARHGEF12,YWHAE,UBC,ARHGEF16,BAD,SQSTM1,RPS27A,NGFRAP1,ARHGEF1,IKBKB,PRKCI,CASP2,ARHGEF2,ARHGEF17,UBB,RELA,ARHGEF9,NCSTN,ITSN1,PLEKHG2,HDAC2
R-HSA-3858494	Beta-catenin independent WNT signaling	0.0801413030792192	-2.52396391387115	144	48	0.0210896309314587	2276	8202	23112,5689,5693,5713,2535,5715,9491,2783,805,5707,5687,5696,1499,163,51764,5717,6885,7314,2787,1856,5686,5694,8321,7311,5692,2788,5702,5695,5682,5710,5691,6934,7316,5719,6233,5714,59345,5709,160,1213,5690,10197,9861,5705,4343,5700,1175,192669	TNRC6B,PSMB1,PSMB5,PSMD7,FZD2,PSMD9,PSMF1,GNB2,CALM2,PSMD1,PSMA6,PSMB8,CTNNB1,AP2B1,GNG13,PSMD11,MAP3K7,UBB,GNG5,DVL2,PSMA5,PSMB6,FZD1,UBA52,PSMB4,GNG7,PSMC3,PSMB7,PSMA1,PSMD4,PSMB3,TCF7L2,UBC,PSMD13,RPS27A,PSMD8,GNB4,PSMD3,AP2A1,CLTC,PSMB2,PSME3,PSMD6,PSMC5,MOV10,PSMC1,AP2S1,AGO3
R-HSA-400253	Circadian Clock	0.0807071989903799	-2.51692750086485	63	23	0.0101054481546573	2276	8202	23411,7311,2908,1454,4209,8553,7316,8864,6233,5187,79365,406,5500,1408,1628,6907,9575,10891,7314,25819,9572,1386,8945	SIRT1,UBA52,NR3C1,CSNK1E,MEF2D,BHLHE40,UBC,PER2,RPS27A,PER1,BHLHE41,ARNTL,PPP1CB,CRY2,DBP,TBL1X,CLOCK,PPARGC1A,UBB,NOCT,NR1D1,ATF2,BTRC
R-HSA-429958	mRNA decay by 3' to 5' exoribonuclease	0.0852658451936758	-2.46198131271522	12	6	0.00263620386643234	2276	8202	5393,23404,54512,118460,23016,11340	EXOSC9,EXOSC2,EXOSC4,EXOSC6,EXOSC7,EXOSC8
R-HSA-111447	Activation of BAD and translocation to mitochondria	0.0924612776505848	-2.38096534210325	15	7	0.00307557117750439	2276	8202	572,10971,7534,7531,7533,208,7532	BAD,YWHAQ,YWHAZ,YWHAE,YWHAH,AKT2,YWHAG
R-HSA-205043	NRIF signals cell death from the nucleus	0.0924612776505848	-2.38096534210325	15	7	0.00307557117750439	2276	8202	7311,8878,7314,51107,6233,23385,7316	UBA52,SQSTM1,UBB,APH1A,RPS27A,NCSTN,UBC
R-HSA-74752	Signaling by Insulin receptor	0.093800709127864	-2.36658286299998	304	95	0.0417398945518453	2276	8202	161742,10142,200734,5564,1848,2475,4763,523,5565,5894,5604,5526,805,5707,5696,5687,6464,5518,5296,28956,6194,11221,5494,7414,1977,529,64223,7311,208,5695,1742,535,5571,6009,5529,817,5719,6233,5714,5709,4296,5527,5690,6198,81617,5705,9861,5700,5528,284,5689,5693,673,2335,7094,5245,5562,30849,5713,84335,5715,1847,9491,5781,23545,3717,145957,5717,2065,51606,7314,9114,5686,1843,6709,5694,5170,5289,5692,1975,5702,5682,3845,5710,4140,5691,7316,7248,51382,51422,369,389541,84078,10197,528	SPRED1,AKAP9,SPRED2,PRKAB1,DUSP6,MTOR,NF1,ATP6V1A,PRKAB2,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,PIK3R2,LAMTOR2,RPS6,DUSP10,PPM1A,VCL,EIF4E,ATP6V1E1,MLST8,UBA52,AKT2,PSMB7,DLG4,ATP6V0A1,PRKAG1,RHEB,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PPP2R5C,PSMB2,RPS6KB1,CAB39L,PSMC5,PSMD6,PSMC1,PPP2R5D,ANGPT1,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PRKAA1,PIK3R4,PSMD7,AKT1S1,PSMD9,DUSP5,PSMF1,PTPN11,ATP6V0A2,JAK2,NRG4,PSMD11,ERBB3,ATP6V1H,UBB,ATP6V0D1,PSMA5,DUSP1,SPTAN1,PSMB6,PDPK1,PIK3C3,PSMB4,EIF4B,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,TSC1,ATP6V1D,PRKAG2,ARAF,LAMTOR4,KBTBD7,PSME3,ATP6V1C1
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.094525985792269	-2.35888050035427	42	16	0.0070298769771529	2276	8202	3054,64216,7978,2551,54205,4209,506,11232,2553,23082,6742,6907,2101,10891,1386,9572	HCFC1,TFB2M,MTERF1,GABPA,CYCS,MEF2D,ATP5B,POLG2,GABPB1,PPRC1,SSBP1,TBL1X,ESRRA,PPARGC1A,ATF2,NR1D1
R-HSA-112399	IRS-mediated signalling	0.0952743381228487	-2.35099477926446	277	87	0.0382249560632689	2276	8202	161742,10142,200734,5564,1848,2475,4763,5565,5894,5604,5526,805,5707,5696,5687,6464,5518,5296,28956,6194,11221,5494,7414,1977,64223,7311,208,5695,1742,5571,6009,5529,817,5719,6233,5714,5709,4296,5527,5690,6198,81617,5705,9861,5700,5528,284,5689,5693,673,2335,7094,5245,5562,30849,5713,84335,5715,1847,9491,5781,3717,145957,5717,2065,7314,5686,1843,6709,5694,5170,5289,5692,1975,5702,5682,3845,5710,4140,5691,7316,7248,51422,369,389541,84078,10197	SPRED1,AKAP9,SPRED2,PRKAB1,DUSP6,MTOR,NF1,PRKAB2,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,PIK3R2,LAMTOR2,RPS6,DUSP10,PPM1A,VCL,EIF4E,MLST8,UBA52,AKT2,PSMB7,DLG4,PRKAG1,RHEB,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PPP2R5C,PSMB2,RPS6KB1,CAB39L,PSMC5,PSMD6,PSMC1,PPP2R5D,ANGPT1,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PRKAA1,PIK3R4,PSMD7,AKT1S1,PSMD9,DUSP5,PSMF1,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,PSMB6,PDPK1,PIK3C3,PSMB4,EIF4B,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,TSC1,PRKAG2,ARAF,LAMTOR4,KBTBD7,PSME3
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.0965591627650235	-2.33759937284951	77	27	0.0118629173989455	2276	8202	3015,723790,8367,7157,85236,8363,8340,8368,7290,8347,8360,8365,54386,3012,890,8362,65057,4001,8364,26277,3014,1027,3159,128312,3017,8331,7014	H2AFZ,HIST2H2AA4,HIST1H4E,TP53,HIST1H2BK,HIST1H4J,HIST1H2BL,HIST1H4L,HIRA,HIST1H2BC,HIST1H4D,HIST1H4H,TERF2IP,HIST1H2AE,CCNA2,HIST1H4K,ACD,LMNB1,HIST1H4C,TINF2,H2AFX,CDKN1B,HMGA1,HIST3H2BB,HIST1H2BD,HIST1H2AJ,TERF2
R-HSA-70326	Glucose metabolism	0.0965591627650235	-2.33759937284951	77	27	0.0118629173989455	2276	8202	2597,7311,7360,5837,5208,4191,5257,5209,83440,5566,7316,805,5091,5230,6233,5518,226,5105,1468,2997,5224,2805,5256,7314,5528,5261,6576	GAPDH,UBA52,UGP2,PYGM,PFKFB2,MDH2,PHKB,PFKFB3,ADPGK,PRKACA,UBC,CALM2,PC,PGK1,RPS27A,PPP2R1A,ALDOA,PCK1,SLC25A10,GYS1,PGAM2,GOT1,PHKA2,UBB,PPP2R5D,PHKG2,SLC25A1
R-HSA-182218	Nef Mediated CD8 Down-regulation	0.0986525500312257	-2.3161511975701	7	4	0.00175746924428822	2276	8202	163,51606,1175,160	AP2B1,ATP6V1H,AP2S1,AP2A1
R-HSA-111471	Apoptotic factor-mediated response	0.0986525500312257	-2.3161511975701	7	4	0.00175746924428822	2276	8202	56616,54205,840,842	DIABLO,CYCS,CASP7,CASP9
R-HSA-110362	POLB-Dependent Long Patch Base Excision Repair	0.0986525500312257	-2.3161511975701	7	4	0.00175746924428822	2276	8202	3978,5423,10038,2237	LIG1,POLB,PARP2,FEN1
R-HSA-5649702	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	0.0986525500312257	-2.3161511975701	7	4	0.00175746924428822	2276	8202	5423,11284,79661,7515	POLB,PNKP,NEIL1,XRCC1
R-HSA-2980767	Activation of NIMA Kinases NEK9, NEK6, NEK7	0.0986525500312257	-2.3161511975701	7	4	0.00175746924428822	2276	8202	9133,140609,983,91754	CCNB2,NEK7,CDK1,NEK9
R-HSA-164938	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	0.0991516114779501	-2.31110517121901	21	9	0.00395430579964851	2276	8202	163,567,162,51606,164,1175,160,3105,8907	AP2B1,B2M,AP1B1,ATP6V1H,AP1G1,AP2S1,AP2A1,HLA-A,AP1M1
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.10026102064328	-2.2999782872337	87	30	0.0131810193321617	2276	8202	7091,3015,723790,8367,7090,607,85236,8350,3021,90780,8363,8340,8368,5929,8347,8360,6934,8365,3012,8362,1499,8607,4609,8364,3014,653604,9070,128312,3017,8331	TLE4,H2AFZ,HIST2H2AA4,HIST1H4E,TLE3,BCL9,HIST1H2BK,HIST1H3A,H3F3B,PYGO2,HIST1H4J,HIST1H2BL,HIST1H4L,RBBP5,HIST1H2BC,HIST1H4D,TCF7L2,HIST1H4H,HIST1H2AE,HIST1H4K,CTNNB1,RUVBL1,MYC,HIST1H4C,H2AFX,HIST2H3D,ASH2L,HIST3H2BB,HIST1H2BD,HIST1H2AJ
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.105682356732613	-2.24731731836747	68	24	0.0105448154657293	2276	8202	8367,55183,29086,85236,9025,8340,8363,8368,8347,8360,7341,8365,7520,8362,7336,7158,8364,2547,3014,51720,165918,128312,3017,7334	HIST1H4E,RIF1,BABAM1,HIST1H2BK,RNF8,HIST1H2BL,HIST1H4J,HIST1H4L,HIST1H2BC,HIST1H4D,SUMO1,HIST1H4H,XRCC5,HIST1H4K,UBE2V2,TP53BP1,HIST1H4C,XRCC6,H2AFX,UIMC1,RNF168,HIST3H2BB,HIST1H2BD,UBE2N
R-HSA-427359	SIRT1 negatively regulates rRNA Expression	0.108913249891306	-2.21720358618453	65	23	0.0101054481546573	2276	8202	23411,3015,723790,8367,6908,85236,8350,3021,8363,8340,8368,23378,8347,8360,8365,3012,8362,8364,3014,653604,128312,3017,8331	SIRT1,H2AFZ,HIST2H2AA4,HIST1H4E,TBP,HIST1H2BK,HIST1H3A,H3F3B,HIST1H4J,HIST1H2BL,HIST1H4L,RRP8,HIST1H2BC,HIST1H4D,HIST1H4H,HIST1H2AE,HIST1H4K,HIST1H4C,H2AFX,HIST2H3D,HIST3H2BB,HIST1H2BD,HIST1H2AJ
R-HSA-5663084	Diseases of carbohydrate metabolism	0.114260461350411	-2.16927468796938	10	5	0.00219683655536028	2276	8202	2997,7311,7314,6233,7316	GYS1,UBA52,UBB,RPS27A,UBC
R-HSA-111367	SLBP independent Processing of Histone Pre-mRNAs	0.114260461350411	-2.16927468796938	10	5	0.00219683655536028	2276	8202	6635,6637,25888,4686,84967	SNRPE,SNRPG,ZNF473,NCBP1,LSM10
R-HSA-2151209	Activation of PPARGC1A (PGC-1alpha) by phosphorylation	0.114260461350411	-2.16927468796938	10	5	0.00219683655536028	2276	8202	5571,5564,51422,10891,5565	PRKAG1,PRKAB1,PRKAG2,PPARGC1A,PRKAB2
R-HSA-1660517	Synthesis of PIPs at the late endosome membrane	0.114260461350411	-2.16927468796938	10	5	0.00219683655536028	2276	8202	5289,200576,9110,55697,30849	PIK3C3,PIKFYVE,MTMR4,VAC14,PIK3R4
R-HSA-901032	ER Quality Control Compartment (ERQC)	0.114260461350411	-2.16927468796938	10	5	0.00219683655536028	2276	8202	56886,84447,11253,80267,6400	UGGT1,SYVN1,MAN1B1,EDEM3,SEL1L
R-HSA-3229121	Glycogen storage diseases	0.114260461350411	-2.16927468796938	10	5	0.00219683655536028	2276	8202	2997,7311,7314,6233,7316	GYS1,UBA52,UBB,RPS27A,UBC
R-HSA-3785653	Myoclonic epilepsy of Lafora	0.114260461350411	-2.16927468796938	10	5	0.00219683655536028	2276	8202	2997,7311,7314,6233,7316	GYS1,UBA52,UBB,RPS27A,UBC
R-HSA-2465910	MASTL Facilitates Mitotic Progression	0.114260461350411	-2.16927468796938	10	5	0.00219683655536028	2276	8202	10776,5518,983,84930,2029	ARPP19,PPP2R1A,CDK1,MASTL,ENSA
R-HSA-164940	Nef mediated downregulation of MHC class I complex cell surface expression	0.114260461350411	-2.16927468796938	10	5	0.00219683655536028	2276	8202	567,162,164,3105,8907	B2M,AP1B1,AP1G1,HLA-A,AP1M1
R-HSA-74751	Insulin receptor signalling cascade	0.116685707517577	-2.14827121919013	280	87	0.0382249560632689	2276	8202	161742,10142,200734,5564,1848,2475,4763,5565,5894,5604,5526,805,5707,5696,5687,6464,5518,5296,28956,6194,11221,5494,7414,1977,64223,7311,208,5695,1742,5571,6009,5529,817,5719,6233,5714,5709,4296,5527,5690,6198,81617,5705,9861,5700,5528,284,5689,5693,673,2335,7094,5245,5562,30849,5713,84335,5715,1847,9491,5781,3717,145957,5717,2065,7314,5686,1843,6709,5694,5170,5289,5692,1975,5702,5682,3845,5710,4140,5691,7316,7248,51422,369,389541,84078,10197	SPRED1,AKAP9,SPRED2,PRKAB1,DUSP6,MTOR,NF1,PRKAB2,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,PIK3R2,LAMTOR2,RPS6,DUSP10,PPM1A,VCL,EIF4E,MLST8,UBA52,AKT2,PSMB7,DLG4,PRKAG1,RHEB,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PPP2R5C,PSMB2,RPS6KB1,CAB39L,PSMC5,PSMD6,PSMC1,PPP2R5D,ANGPT1,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PRKAA1,PIK3R4,PSMD7,AKT1S1,PSMD9,DUSP5,PSMF1,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,PSMB6,PDPK1,PIK3C3,PSMB4,EIF4B,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,TSC1,PRKAG2,ARAF,LAMTOR4,KBTBD7,PSME3
R-HSA-2046104	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	0.122407512428531	-2.10039953473725	13	6	0.00263620386643234	2276	8202	3992,9415,60481,3295,51,10005	FADS1,FADS2,ELOVL5,HSD17B4,ACOX1,ACOT8
R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	0.122407512428531	-2.10039953473725	13	6	0.00263620386643234	2276	8202	3992,9415,60481,3295,51,10005	FADS1,FADS2,ELOVL5,HSD17B4,ACOX1,ACOT8
R-HSA-5357786	TNFR1-induced proapoptotic signaling	0.122407512428531	-2.10039953473725	13	6	0.00263620386643234	2276	8202	7375,1540,7128,7186,27005,8772	USP4,CYLD,TNFAIP3,TRAF2,USP21,FADD
R-HSA-5210891	Uptake and function of anthrax toxins	0.122407512428531	-2.10039953473725	13	6	0.00263620386643234	2276	8202	805,5609,84168,5608,5606,5604	CALM2,MAP2K7,ANTXR1,MAP2K6,MAP2K3,MAP2K1
R-HSA-1660516	Synthesis of PIPs at the early endosome membrane	0.122407512428531	-2.10039953473725	13	6	0.00263620386643234	2276	8202	5289,200576,9110,55697,55361,30849	PIK3C3,PIKFYVE,MTMR4,VAC14,PI4K2A,PIK3R4
R-HSA-1483213	Synthesis of PE	0.122407512428531	-2.10039953473725	13	6	0.00263620386643234	2276	8202	162466,85465,64900,64850,1119,55500	PHOSPHO1,EPT1,LPIN3,ETNPPL,CHKA,ETNK1
R-HSA-2428924	IGF1R signaling cascade	0.124483552907021	-2.08358167696852	281	87	0.0382249560632689	2276	8202	161742,10142,200734,5564,1848,2475,4763,5565,5894,5604,5526,805,5707,5696,5687,6464,5518,5296,28956,6194,11221,5494,7414,1977,64223,7311,208,5695,1742,5571,6009,5529,817,5719,6233,5714,5709,4296,5527,5690,6198,81617,5705,9861,5700,5528,284,5689,5693,673,2335,7094,5245,5562,30849,5713,84335,5715,1847,9491,5781,3717,145957,5717,2065,7314,5686,1843,6709,5694,5170,5289,5692,1975,5702,5682,3845,5710,4140,5691,7316,7248,51422,369,389541,84078,10197	SPRED1,AKAP9,SPRED2,PRKAB1,DUSP6,MTOR,NF1,PRKAB2,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,PIK3R2,LAMTOR2,RPS6,DUSP10,PPM1A,VCL,EIF4E,MLST8,UBA52,AKT2,PSMB7,DLG4,PRKAG1,RHEB,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PPP2R5C,PSMB2,RPS6KB1,CAB39L,PSMC5,PSMD6,PSMC1,PPP2R5D,ANGPT1,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PRKAA1,PIK3R4,PSMD7,AKT1S1,PSMD9,DUSP5,PSMF1,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,PSMB6,PDPK1,PIK3C3,PSMB4,EIF4B,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,TSC1,PRKAG2,ARAF,LAMTOR4,KBTBD7,PSME3
R-HSA-2428928	IRS-related events triggered by IGF1R	0.124483552907021	-2.08358167696852	281	87	0.0382249560632689	2276	8202	161742,10142,200734,5564,1848,2475,4763,5565,5894,5604,5526,805,5707,5696,5687,6464,5518,5296,28956,6194,11221,5494,7414,1977,64223,7311,208,5695,1742,5571,6009,5529,817,5719,6233,5714,5709,4296,5527,5690,6198,81617,5705,9861,5700,5528,284,5689,5693,673,2335,7094,5245,5562,30849,5713,84335,5715,1847,9491,5781,3717,145957,5717,2065,7314,5686,1843,6709,5694,5170,5289,5692,1975,5702,5682,3845,5710,4140,5691,7316,7248,51422,369,389541,84078,10197	SPRED1,AKAP9,SPRED2,PRKAB1,DUSP6,MTOR,NF1,PRKAB2,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,PIK3R2,LAMTOR2,RPS6,DUSP10,PPM1A,VCL,EIF4E,MLST8,UBA52,AKT2,PSMB7,DLG4,PRKAG1,RHEB,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PPP2R5C,PSMB2,RPS6KB1,CAB39L,PSMC5,PSMD6,PSMC1,PPP2R5D,ANGPT1,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PRKAA1,PIK3R4,PSMD7,AKT1S1,PSMD9,DUSP5,PSMF1,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,PSMB6,PDPK1,PIK3C3,PSMB4,EIF4B,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,TSC1,PRKAG2,ARAF,LAMTOR4,KBTBD7,PSME3
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.124483552907021	-2.08358167696852	281	87	0.0382249560632689	2276	8202	161742,10142,200734,5564,1848,2475,4763,5565,5894,5604,5526,805,5707,5696,5687,6464,5518,5296,28956,6194,11221,5494,7414,1977,64223,7311,208,5695,1742,5571,6009,5529,817,5719,6233,5714,5709,4296,5527,5690,6198,81617,5705,9861,5700,5528,284,5689,5693,673,2335,7094,5245,5562,30849,5713,84335,5715,1847,9491,5781,3717,145957,5717,2065,7314,5686,1843,6709,5694,5170,5289,5692,1975,5702,5682,3845,5710,4140,5691,7316,7248,51422,369,389541,84078,10197	SPRED1,AKAP9,SPRED2,PRKAB1,DUSP6,MTOR,NF1,PRKAB2,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,PIK3R2,LAMTOR2,RPS6,DUSP10,PPM1A,VCL,EIF4E,MLST8,UBA52,AKT2,PSMB7,DLG4,PRKAG1,RHEB,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PPP2R5C,PSMB2,RPS6KB1,CAB39L,PSMC5,PSMD6,PSMC1,PPP2R5D,ANGPT1,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PRKAA1,PIK3R4,PSMD7,AKT1S1,PSMD9,DUSP5,PSMF1,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,PSMB6,PDPK1,PIK3C3,PSMB4,EIF4B,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,TSC1,PRKAG2,ARAF,LAMTOR4,KBTBD7,PSME3
R-HSA-937072	TRAF6 mediated induction of TAK1 complex	0.12645948023521	-2.06783333647233	16	7	0.00307557117750439	2276	8202	7311,6885,7314,10454,257397,6233,7316	UBA52,MAP3K7,UBB,TAB1,TAB3,RPS27A,UBC
R-HSA-156711	Polo-like kinase mediated events	0.12645948023521	-2.06783333647233	16	7	0.00307557117750439	2276	8202	132660,993,7465,995,9133,1063,55957	LIN54,CDC25A,WEE1,CDC25C,CCNB2,CENPF,LIN37
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1	0.12645948023521	-2.06783333647233	16	7	0.00307557117750439	2276	8202	8517,6885,5609,8767,10454,257397,5601	IKBKG,MAP3K7,MAP2K7,RIPK2,TAB1,TAB3,MAPK9
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.128072471392948	-2.05515899252609	19	8	0.00351493848857645	2276	8202	7311,6464,6233,3845,3320,7314,7316,11140	UBA52,SHC1,RPS27A,KRAS,HSP90AA1,UBB,UBC,CDC37
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.128072471392948	-2.05515899252609	19	8	0.00351493848857645	2276	8202	7311,6464,6233,3845,3320,7314,7316,11140	UBA52,SHC1,RPS27A,KRAS,HSP90AA1,UBB,UBC,CDC37
R-HSA-1643713	Signaling by EGFR in Cancer	0.128072471392948	-2.05515899252609	19	8	0.00351493848857645	2276	8202	7311,6464,6233,3845,3320,7314,7316,11140	UBA52,SHC1,RPS27A,KRAS,HSP90AA1,UBB,UBC,CDC37
R-HSA-69273	Cyclin A/B1 associated events during G2/M transition	0.128152001148158	-2.05453821062361	22	9	0.00395430579964851	2276	8202	993,7465,890,7514,902,5518,995,9133,983	CDC25A,WEE1,CCNA2,XPO1,CCNH,PPP2R1A,CDC25C,CCNB2,CDK1
R-HSA-189200	Hexose transport	0.130321589428333	-2.03775011841271	47	17	0.00746924428822496	2276	8202	6517,23511,8480,53371,9631,92579,8021,23165,129401,5903,4927,2542,55746,23636,9972,9818,8086	SLC2A4,NUP188,RAE1,NUP54,NUP155,G6PC3,NUP214,NUP205,NUP35,RANBP2,NUP88,SLC37A4,NUP133,NUP62,NUP153,NUP58,AAAS
R-HSA-166520	Signalling by NGF	0.130443682681116	-2.03681369570031	430	130	0.0571177504393673	2276	8202	161742,10142,200734,5607,1848,2475,4763,5894,5604,1147,5526,7531,5566,27237,1399,805,5707,5696,6196,5687,6464,5518,5296,28956,3551,835,1785,11221,8503,163,1027,253260,10768,9828,7414,5970,6453,64223,7311,2931,26574,8767,51107,208,842,1894,5695,1742,572,5529,817,5719,6233,27018,5714,5709,4296,2932,5527,5690,5705,9861,4343,5700,1175,5528,23385,284,3066,64857,5573,5125,23112,5689,5693,673,2335,7094,5245,5713,5900,4205,57142,84335,23239,9252,5715,9491,1847,5581,466,8878,9138,5781,5584,9181,3717,145957,5717,2065,5598,7314,6774,5686,5694,1843,6709,6199,5170,10451,6868,5692,7867,3164,5702,5682,3845,23365,6016,5710,2002,4140,5691,7316,369,160,84078,10197,23229,192669	SPRED1,AKAP9,SPRED2,MAP2K5,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,PPP2R5B,YWHAE,PRKACA,ARHGEF16,CRKL,CALM2,PSMD1,PSMB8,RPS6KA2,PSMA6,SHC1,PPP2R1A,PIK3R2,LAMTOR2,IKBKB,CASP2,DNM2,DUSP10,PIK3R3,AP2B1,CDKN1B,RICTOR,AHCYL1,ARHGEF17,VCL,RELA,ITSN1,MLST8,UBA52,GSK3A,AATF,RIPK2,APH1A,AKT2,CASP9,ECT2,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,NGFRAP1,PSMD8,PSMD3,MAP3K11,GSK3B,PPP2R5C,PSMB2,PSMC5,PSMD6,MOV10,PSMC1,AP2S1,PPP2R5D,NCSTN,ANGPT1,HDAC2,PLEKHG2,PRKAR1A,PCSK5,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,RALGDS,MEF2A,RTN4,AKT1S1,PHLPP1,RPS6KA5,PSMD9,PSMF1,DUSP5,PRKCE,ATF1,SQSTM1,ARHGEF1,PTPN11,PRKCI,ARHGEF2,JAK2,NRG4,PSMD11,ERBB3,MAPK7,UBB,STAT3,PSMA5,PSMB6,DUSP1,SPTAN1,RPS6KB2,PDPK1,VAV3,ADAM17,PSMB4,MAPKAPK3,NR4A1,PSMC3,PSMA1,KRAS,ARHGEF12,RIT1,PSMD4,ELK1,MARK3,PSMB3,UBC,ARAF,AP2A1,KBTBD7,PSME3,ARHGEF9,AGO3
R-HSA-73728	RNA Polymerase I Promoter Opening	0.133400355292402	-2.01440048214283	60	21	0.00922671353251318	2276	8202	3015,723790,8367,85236,8350,3021,8363,8340,8368,8347,8360,8365,7343,3012,8362,8364,3014,653604,128312,3017,8331	H2AFZ,HIST2H2AA4,HIST1H4E,HIST1H2BK,HIST1H3A,H3F3B,HIST1H4J,HIST1H2BL,HIST1H4L,HIST1H2BC,HIST1H4D,HIST1H4H,UBTF,HIST1H2AE,HIST1H4K,HIST1H4C,H2AFX,HIST2H3D,HIST3H2BB,HIST1H2BD,HIST1H2AJ
R-HSA-111464	SMAC-mediated dissociation of IAP:caspase complexes	0.134542753525268	-2.00587326037389	5	3	0.00131810193321617	2276	8202	56616,840,842	DIABLO,CASP7,CASP9
R-HSA-1614517	Sulfide oxidation to sulfate	0.134542753525268	-2.00587326037389	5	3	0.00131810193321617	2276	8202	58472,6821,1468	SQRDL,SUOX,SLC25A10
R-HSA-111461	Cytochrome c-mediated apoptotic response	0.134542753525268	-2.00587326037389	5	3	0.00131810193321617	2276	8202	54205,840,842	CYCS,CASP7,CASP9
R-HSA-111463	SMAC binds to IAPs	0.134542753525268	-2.00587326037389	5	3	0.00131810193321617	2276	8202	56616,840,842	DIABLO,CASP7,CASP9
R-HSA-69478	G2/M DNA replication checkpoint	0.134542753525268	-2.00587326037389	5	3	0.00131810193321617	2276	8202	7465,9133,983	WEE1,CCNB2,CDK1
R-HSA-111459	Activation of caspases through apoptosome-mediated cleavage	0.134542753525268	-2.00587326037389	5	3	0.00131810193321617	2276	8202	54205,840,842	CYCS,CASP7,CASP9
R-HSA-203641	NOSTRIN mediated eNOS trafficking	0.134542753525268	-2.00587326037389	5	3	0.00131810193321617	2276	8202	857,8976,1785	CAV1,WASL,DNM2
R-HSA-446199	Synthesis of Dolichyl-phosphate	0.134542753525268	-2.00587326037389	5	3	0.00131810193321617	2276	8202	79947,4597,57171	DHDDS,MVD,DOLPP1
R-HSA-111469	SMAC-mediated apoptotic response	0.134542753525268	-2.00587326037389	5	3	0.00131810193321617	2276	8202	56616,840,842	DIABLO,CASP7,CASP9
R-HSA-212300	PRC2 methylates histones and DNA	0.137901584236284	-1.98121500595095	70	24	0.0105448154657293	2276	8202	3015,723790,5931,8367,85236,8350,3021,8363,8340,8368,8347,5252,8360,8365,3012,8362,8364,3014,653604,128312,3017,22823,8331,3720	H2AFZ,HIST2H2AA4,RBBP7,HIST1H4E,HIST1H2BK,HIST1H3A,H3F3B,HIST1H4J,HIST1H2BL,HIST1H4L,HIST1H2BC,PHF1,HIST1H4D,HIST1H4H,HIST1H2AE,HIST1H4K,HIST1H4C,H2AFX,HIST2H3D,HIST3H2BB,HIST1H2BD,MTF2,HIST1H2AJ,JARID2
R-HSA-5683057	MAPK family signaling cascades	0.143755981843889	-1.93963798734341	273	84	0.0369068541300527	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,5566,805,5707,5687,5696,6464,998,5518,8555,28956,11221,7414,7311,5695,8550,1742,7297,983,5529,817,7514,5719,6233,5714,5709,4296,5690,5527,5705,9861,4343,5700,5528,284,23112,5689,5693,673,2335,7094,5245,5713,3337,5715,1847,9491,3725,4609,5781,3717,145957,5717,2065,7314,5686,1843,6709,5694,5058,5692,5702,5682,3845,989,5710,4140,5691,7316,8202,369,3569,5597,84078,10197,8556,192669	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,PRKACA,CALM2,PSMD1,PSMA6,PSMB8,SHC1,CDC42,PPP2R1A,CDC14B,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,MAPKAPK5,DLG4,TYK2,CDK1,PPP2R5E,CAMK2D,XPO1,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,ANGPT1,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,DNAJB1,PSMD9,DUSP5,PSMF1,JUN,MYC,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,PSMB6,PAK1,PSMB4,PSMC3,PSMA1,KRAS,SEPT7,PSMD4,MARK3,PSMB3,UBC,NCOA3,ARAF,IL6,MAPK6,KBTBD7,PSME3,CDC14A,AGO3
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	0.144637077603188	-1.93352758716636	342	104	0.0456942003514939	2276	8202	23291,10142,200734,161742,1848,4763,2475,5894,5604,1147,5526,805,5707,5696,5687,6464,5518,3551,5296,28956,1027,11221,8503,253260,10768,7414,5970,64223,7311,2931,208,842,5695,1742,7335,572,5529,8517,817,5719,6233,5714,5709,4296,5690,2932,5527,5705,9861,10454,4343,5528,5700,284,7334,5689,23112,5693,673,2335,257397,7094,5245,5713,84335,23239,5715,9491,1847,3725,5601,5781,3717,145957,5717,2065,6885,7314,5686,5694,6709,1843,6199,5058,5170,10451,5692,5609,3164,5702,10892,5682,3845,5710,2353,4140,5691,7316,369,7322,84078,10197,8945,192669	FBXW11,AKAP9,SPRED2,SPRED1,DUSP6,NF1,MTOR,RAF1,MAP2K1,CHUK,PPP2R5B,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,IKBKB,PIK3R2,LAMTOR2,CDKN1B,DUSP10,PIK3R3,RICTOR,AHCYL1,VCL,RELA,MLST8,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,UBE2V1,BAD,PPP2R5E,IKBKG,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,GSK3B,PPP2R5C,PSMC5,PSMD6,TAB1,MOV10,PPP2R5D,PSMC1,ANGPT1,UBE2N,PSMB1,TNRC6B,PSMB5,BRAF,FN1,TAB3,TLN1,PHB,PSMD7,AKT1S1,PHLPP1,PSMD9,PSMF1,DUSP5,JUN,MAPK9,PTPN11,JAK2,NRG4,PSMD11,ERBB3,MAP3K7,UBB,PSMA5,PSMB6,SPTAN1,DUSP1,RPS6KB2,PAK1,PDPK1,VAV3,PSMB4,MAP2K7,NR4A1,PSMC3,MALT1,PSMA1,KRAS,PSMD4,FOS,MARK3,PSMB3,UBC,ARAF,UBE2D2,KBTBD7,PSME3,BTRC,AGO3
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	0.147514324279612	-1.91382999415742	64	22	0.00966608084358524	2276	8202	3015,723790,8367,85236,8350,3021,8363,8340,8368,8347,8360,23028,8365,3012,8362,8364,3014,653604,128312,3017,23081,8331	H2AFZ,HIST2H2AA4,HIST1H4E,HIST1H2BK,HIST1H3A,H3F3B,HIST1H4J,HIST1H2BL,HIST1H4L,HIST1H2BC,HIST1H4D,KDM1A,HIST1H4H,HIST1H2AE,HIST1H4K,HIST1H4C,H2AFX,HIST2H3D,HIST3H2BB,HIST1H2BD,KDM4C,HIST1H2AJ
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	0.152632929895694	-1.87971939117243	61	21	0.00922671353251318	2276	8202	10451,7311,26574,51107,1894,23365,7531,7316,27237,572,8878,6233,27018,835,9181,9828,7314,23229,23385,64857,6453	VAV3,UBA52,AATF,APH1A,ECT2,ARHGEF12,YWHAE,UBC,ARHGEF16,BAD,SQSTM1,RPS27A,NGFRAP1,CASP2,ARHGEF2,ARHGEF17,UBB,ARHGEF9,NCSTN,PLEKHG2,ITSN1
R-HSA-375170	CDO in myogenesis	0.15400961744682	-1.87074022756511	29	11	0.00483304042179262	2276	8202	6938,9043,1499,998,1495,5608,6929,100271849,4205,4209,663	TCF12,SPAG9,CTNNB1,CDC42,CTNNA1,MAP2K6,TCF3,MEF2B,MEF2A,MEF2D,BNIP2
R-HSA-525793	Myogenesis	0.15400961744682	-1.87074022756511	29	11	0.00483304042179262	2276	8202	6938,9043,1499,998,1495,5608,6929,100271849,4205,4209,663	TCF12,SPAG9,CTNNB1,CDC42,CTNNA1,MAP2K6,TCF3,MEF2B,MEF2A,MEF2D,BNIP2
R-HSA-111453	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	0.155190923608273	-1.86309915484861	8	4	0.00175746924428822	2276	8202	572,90427,598,5366	BAD,BMF,BCL2L1,PMAIP1
R-HSA-450520	HuR (ELAVL1) binds and stabilizes mRNA	0.155190923608273	-1.86309915484861	8	4	0.00175746924428822	2276	8202	8125,7514,1994,8021	ANP32A,XPO1,ELAVL1,NUP214
R-HSA-1614558	Degradation of cysteine and homocysteine	0.155190923608273	-1.86309915484861	8	4	0.00175746924428822	2276	8202	58472,6821,1491,1468	SQRDL,SUOX,CTH,SLC25A10
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	0.15771703040954	-1.8469527983928	26	10	0.00439367311072056	2276	8202	3146,8517,8767,257397,3551,1147,6885,4791,10454,5970	HMGB1,IKBKG,RIPK2,TAB3,IKBKB,CHUK,MAP3K7,NFKB2,TAB1,RELA
R-HSA-983189	Kinesins	0.15771703040954	-1.8469527983928	26	10	0.00439367311072056	2276	8202	3833,3796,24137,10112,3831,3835,29127,11004,1062,3832	KIFC1,KIF2A,KIF4A,KIF20A,KLC1,KIF22,RACGAP1,KIF2C,CENPE,KIF11
R-HSA-70614	Amino acid synthesis and interconversion (transamination)	0.161094235615216	-1.8257657708471	23	9	0.00395430579964851	2276	8202	2744,883,440,29968,65263,2805,29920,5832,5723	GLS,CCBL1,ASNS,PSAT1,PYCRL,GOT1,PYCR2,ALDH18A1,PSPH
R-HSA-196780	Biotin transport and metabolism	0.163400726393979	-1.81154965107053	11	5	0.00219683655536028	2276	8202	8884,5091,686,64087,56922	SLC5A6,PC,BTD,MCCC2,MCCC1
R-HSA-199983	Golgi to ER Retrograde Transport	0.163400726393979	-1.81154965107053	11	5	0.00219683655536028	2276	8202	22818,8729,1315,9276,22820	COPZ1,GBF1,COPB1,COPB2,COPG1
R-HSA-199997	COPI Mediated Transport	0.163400726393979	-1.81154965107053	11	5	0.00219683655536028	2276	8202	22818,8729,1315,9276,22820	COPZ1,GBF1,COPB1,COPB2,COPG1
R-HSA-71064	Lysine catabolism	0.163400726393979	-1.81154965107053	11	5	0.00219683655536028	2276	8202	501,4967,2639,1738,1743	ALDH7A1,OGDH,GCDH,DLD,DLST
R-HSA-391251	Protein folding	0.163561588371803	-1.81056567228436	55	19	0.00834797891036907	2276	8202	10576,10383,26272,7203,1155,10694,5201,10575,6950,6903,5203,26190,22803,10574,83752,54461,10381,84261,6905	CCT2,TUBB4B,FBXO4,CCT3,TBCB,CCT8,PFDN1,CCT4,TCP1,TBCC,PFDN4,FBXW2,XRN2,CCT7,LONP2,FBXW5,TUBB3,FBXW9,TBCE
R-HSA-5627117	RHO GTPases Activate ROCKs	0.165778779471755	-1.79710103318296	17	7	0.00307557117750439	2276	8202	5500,4660,4627,4637,4659,4628,9475	PPP1CB,PPP1R12B,MYH9,MYL6,PPP1R12A,MYH10,ROCK2
R-HSA-162594	Early Phase of HIV Life Cycle	0.166032189869677	-1.79557359454708	14	6	0.00263620386643234	2276	8202	3978,3159,5478,2547,2237,7520	LIG1,HMGA1,PPIA,XRCC6,FEN1,XRCC5
R-HSA-162658	Golgi Cisternae Pericentriolar Stack Reorganization	0.166032189869677	-1.79557359454708	14	6	0.00263620386643234	2276	8202	8615,5861,2801,9133,983,81876	USO1,RAB1A,GOLGA2,CCNB2,CDK1,RAB1B
R-HSA-3371568	Attenuation phase	0.166032189869677	-1.79557359454708	14	6	0.00263620386643234	2276	8202	3320,3337,10728,3326,3312,3304	HSP90AA1,DNAJB1,PTGES3,HSP90AB1,HSPA8,HSPA1B
R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs	0.17348929455864	-1.75163938433097	36	13	0.00571177504393673	2276	8202	10163,10152,55845,998,8936,4690,8976,10096,10097,10109,10552,147179,10006	WASF2,ABI2,BRK1,CDC42,WASF1,NCK1,WASL,ACTR3,ACTR2,ARPC2,ARPC1A,WIPF2,ABI1
R-HSA-449147	Signaling by Interleukins	0.175974602964911	-1.73741559569216	311	94	0.0413005272407733	2276	8202	23291,10142,200734,161742,1848,4763,5894,5604,1147,6777,5526,5566,1399,805,5707,5696,5687,6464,5518,3551,5296,28956,11221,8503,4791,7414,5970,4215,7311,8767,5695,1742,7335,7297,5529,8517,817,5719,6233,5714,5709,6772,4296,5527,5690,2185,5705,9861,10454,5528,5700,7334,284,5689,3636,673,5693,2335,257397,7094,5245,5713,5715,9491,1847,8878,5781,3717,145957,5717,2065,6885,7314,6774,5686,5694,6709,1843,5692,5702,5682,3845,246330,5710,4140,5691,7316,369,5608,3569,84078,7534,10197,8945	FBXW11,AKAP9,SPRED2,SPRED1,DUSP6,NF1,RAF1,MAP2K1,CHUK,STAT5B,PPP2R5B,PRKACA,CRKL,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,IKBKB,PIK3R2,LAMTOR2,DUSP10,PIK3R3,NFKB2,VCL,RELA,MAP3K3,UBA52,RIPK2,PSMB7,DLG4,UBE2V1,TYK2,PPP2R5E,IKBKG,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,STAT1,MAP3K11,PPP2R5C,PSMB2,PTK2B,PSMC5,PSMD6,TAB1,PPP2R5D,PSMC1,UBE2N,ANGPT1,PSMB1,INPPL1,BRAF,PSMB5,FN1,TAB3,TLN1,PHB,PSMD7,PSMD9,PSMF1,DUSP5,SQSTM1,PTPN11,JAK2,NRG4,PSMD11,ERBB3,MAP3K7,UBB,STAT3,PSMA5,PSMB6,SPTAN1,DUSP1,PSMB4,PSMC3,PSMA1,KRAS,PELI3,PSMD4,MARK3,PSMB3,UBC,ARAF,MAP2K6,IL6,KBTBD7,YWHAZ,PSME3,BTRC
R-HSA-5627083	RHO GTPases regulate CFTR trafficking	0.188239571438942	-1.67003981123933	3	2	0.000878734622144112	2276	8202	23433,57120	RHOQ,GOPC
R-HSA-5624958	ARL13B-mediated ciliary trafficking of INPP5E	0.188239571438942	-1.67003981123933	3	2	0.000878734622144112	2276	8202	5147,200894	PDE6D,ARL13B
R-HSA-111458	Formation of apoptosome	0.188239571438942	-1.67003981123933	3	2	0.000878734622144112	2276	8202	54205,842	CYCS,CASP9
R-HSA-977347	Serine biosynthesis	0.188239571438942	-1.67003981123933	3	2	0.000878734622144112	2276	8202	29968,5723	PSAT1,PSPH
R-HSA-2395516	Electron transport from NADPH to Ferredoxin	0.188239571438942	-1.67003981123933	3	2	0.000878734622144112	2276	8202	112812,2232	FDX1L,FDXR
R-HSA-352238	Breakdown of the nuclear lamina	0.188239571438942	-1.67003981123933	3	2	0.000878734622144112	2276	8202	4001,4000	LMNB1,LMNA
R-HSA-173599	Formation of the active cofactor, UDP-glucuronate	0.188239571438942	-1.67003981123933	3	2	0.000878734622144112	2276	8202	7360,7358	UGP2,UGDH
R-HSA-5339700	TCF7L2 mutants don't bind CTBP	0.188239571438942	-1.67003981123933	3	2	0.000878734622144112	2276	8202	1488,6934	CTBP2,TCF7L2
R-HSA-5688031	Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)	0.188239571438942	-1.67003981123933	3	2	0.000878734622144112	2276	8202	7270,29080	TTF1,CCDC59
R-HSA-170145	Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	0.188239571438942	-1.67003981123933	3	2	0.000878734622144112	2276	8202	890,983	CCNA2,CDK1
R-HSA-165181	Inhibition of TSC complex formation by PKB	0.188239571438942	-1.67003981123933	3	2	0.000878734622144112	2276	8202	7248,208	TSC1,AKT2
R-HSA-535734	Fatty acid, triacylglycerol, and ketone body metabolism	0.18838591068657	-1.6692627036779	212	65	0.0285588752196837	2276	8202	9374,5565,27242,10554,10001,64900,25942,253558,29079,1632,9441,1490,6721,2820,3032,27063,9572,90390,23597,9442,10025,10555,23097,406,9282,9575,10891,10005,2710,4594,84803,79993,54797,55090,3157,4520,84246,112950,9862,9443,6667,3156,2222,55856,6576,3992,23309,7296,9439,60481,1024,7003,56895,2274,8202,5467,51422,3033,51,51586,47,4802,57678,6907,2101	PPT2,PRKAB2,TNFRSF21,AGPAT1,MED6,LPIN3,SIN3A,LCLAT1,MED4,ECI1,MED26,CTGF,SREBF2,GPD2,HADHB,ANKRD1,NR1D1,MED30,ACOT9,MED27,MED16,AGPAT2,CDK19,ARNTL,MED14,CLOCK,PPARGC1A,ACOT8,GK,MUT,GPAT3,ELOVL7,MED18,MED9,HMGCS1,MTF1,MED10,MED8,MED24,MED7,SP1,HMGCR,FDFT1,ACOT13,SLC25A1,FADS1,SIN3B,TXNRD1,MED23,ELOVL5,CDK8,TEAD1,AGPAT4,FHL2,NCOA3,PPARD,PRKAG2,HADH,ACOX1,MED15,ACLY,NFYC,GPAM,TBL1X,ESRRA
R-HSA-389957	Prefoldin mediated transfer of substrate  to CCT/TriC	0.191418978595418	-1.65329064816312	27	10	0.00439367311072056	2276	8202	10576,6950,5203,10383,7203,10574,10694,5201,10575,10381	CCT2,TCP1,PFDN4,TUBB4B,CCT3,CCT7,CCT8,PFDN1,CCT4,TUBB3
R-HSA-157118	Signaling by NOTCH	0.195833853747021	-1.63048866420387	110	35	0.015377855887522	2276	8202	142678,23112,7157,5870,10013,3725,595,6484,488,4609,7314,9794,10959,7091,3280,6868,7311,1024,51107,7090,1871,10014,7316,4192,9759,6233,23220,6400,3516,6907,4343,23385,3066,8650,192669	MIB2,TNRC6B,TP53,RAB6A,HDAC6,JUN,CCND1,ST3GAL4,ATP2A2,MYC,UBB,MAML1,TMED2,TLE4,HES1,ADAM17,UBA52,CDK8,APH1A,TLE3,E2F3,HDAC5,UBC,MDK,HDAC4,RPS27A,DTX4,SEL1L,RBPJ,TBL1X,MOV10,NCSTN,HDAC2,NUMB,AGO3
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	0.197605245708894	-1.62148394691095	24	9	0.00395430579964851	2276	8202	466,6196,1848,5518,4205,5598,2002,9252,5528	ATF1,RPS6KA2,DUSP6,PPP2R1A,MEF2A,MAPK7,ELK1,RPS6KA5,PPP2R5D
R-HSA-2979096	NOTCH2 Activation and Transmission of Signal to the Nucleus	0.203760159942449	-1.59081166335615	21	8	0.00351493848857645	2276	8202	4192,142678,7311,51107,6233,7314,23385,7316	MDK,MIB2,UBA52,APH1A,RPS27A,UBB,NCSTN,UBC
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	0.203760159942449	-1.59081166335615	21	8	0.00351493848857645	2276	8202	10576,6950,10383,7203,10574,10694,10381,10575	CCT2,TCP1,TUBB4B,CCT3,CCT7,CCT8,TUBB3,CCT4
R-HSA-198753	ERK/MAPK targets	0.203760159942449	-1.59081166335615	21	8	0.00351493848857645	2276	8202	6196,1848,5518,4205,5598,2002,9252,5528	RPS6KA2,DUSP6,PPP2R1A,MEF2A,MAPK7,ELK1,RPS6KA5,PPP2R5D
R-HSA-196741	Cobalamin (Cbl, vitamin B12) transport and metabolism	0.203760159942449	-1.59081166335615	21	8	0.00351493848857645	2276	8202	55788,25974,4594,326625,4548,51293,27249,4552	LMBRD1,MMACHC,MUT,MMAB,MTR,CD320,MMADHC,MTRR
R-HSA-1433557	Signaling by SCF-KIT	0.205358591801338	-1.58299759966258	307	92	0.0404217926186292	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,6777,5526,805,5707,5687,5696,6464,8651,5518,5296,28956,11221,8503,1027,253260,7414,64223,2241,7311,2931,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,6772,4296,5690,5527,2932,5705,9861,4343,5700,5528,284,23112,5689,5693,673,2335,7094,5245,5713,1111,84335,23239,5715,1847,9491,5781,3717,145957,5717,2065,7314,6774,5686,1843,6709,6199,5694,5170,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,2886,84078,10197,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,STAT5B,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,SOCS1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,CDKN1B,RICTOR,VCL,MLST8,FER,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,STAT1,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,ANGPT1,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,CHEK1,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,STAT3,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,GRB7,KBTBD7,PSME3,AGO3
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.208560896006221	-1.56752421321048	47	16	0.0070298769771529	2276	8202	7091,3280,7311,1024,7090,10013,10014,7316,9759,6233,4609,3516,6907,9794,7314,3066	TLE4,HES1,UBA52,CDK8,TLE3,HDAC6,HDAC5,UBC,HDAC4,RPS27A,MYC,RBPJ,TBL1X,MAML1,UBB,HDAC2
R-HSA-1660514	Synthesis of PIPs at the Golgi membrane	0.209699705358482	-1.56207874613733	18	7	0.00307557117750439	2276	8202	22908,5289,200576,5298,55697,55361,30849	SACM1L,PIK3C3,PIKFYVE,PI4KB,VAC14,PI4K2A,PIK3R4
R-HSA-3322077	Glycogen synthesis	0.215079464683075	-1.53674771596381	15	6	0.00263620386643234	2276	8202	2997,7311,7360,7314,6233,7316	GYS1,UBA52,UGP2,UBB,RPS27A,UBC
R-HSA-2691232	Constitutive Signaling by NOTCH1 HD Domain Mutants	0.215079464683075	-1.53674771596381	15	6	0.00263620386643234	2276	8202	142678,6868,7311,7314,6233,7316	MIB2,ADAM17,UBA52,UBB,RPS27A,UBC
R-HSA-3134975	Regulation of innate immune responses to cytosolic DNA	0.215079464683075	-1.53674771596381	15	6	0.00263620386643234	2276	8202	7311,51428,7314,6233,7316,23220	UBA52,DDX41,UBB,RPS27A,UBC,DTX4
R-HSA-2691230	Signaling by NOTCH1 HD Domain Mutants in Cancer	0.215079464683075	-1.53674771596381	15	6	0.00263620386643234	2276	8202	142678,6868,7311,7314,6233,7316	MIB2,ADAM17,UBA52,UBB,RPS27A,UBC
R-HSA-500753	Pyrimidine biosynthesis	0.215133468003679	-1.53649666204709	6	3	0.00131810193321617	2276	8202	1723,7372,1854	DHODH,UMPS,DUT
R-HSA-390247	Beta-oxidation of very long chain fatty acids	0.215133468003679	-1.53649666204709	6	3	0.00131810193321617	2276	8202	3295,51,10005	HSD17B4,ACOX1,ACOT8
R-HSA-171319	Telomere Extension By Telomerase	0.215133468003679	-1.53649666204709	6	3	0.00131810193321617	2276	8202	55651,8607,55135	NHP2,RUVBL1,WRAP53
R-HSA-205025	NADE modulates death signalling	0.215133468003679	-1.53649666204709	6	3	0.00131810193321617	2276	8202	7531,27018,835	YWHAE,NGFRAP1,CASP2
R-HSA-5674499	Negative feedback regulation of MAPK pathway	0.215133468003679	-1.53649666204709	6	3	0.00131810193321617	2276	8202	673,5894,5604	BRAF,RAF1,MAP2K1
R-HSA-186763	Downstream signal transduction	0.21654941825026	-1.52993649777046	322	96	0.0421792618629174	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,6777,5526,5566,1399,805,5707,5687,5696,6464,5518,5296,28956,11221,8503,1027,253260,10768,7414,64223,7311,2931,4690,208,842,5695,1742,572,5529,817,5719,6233,5714,6778,5709,6772,4296,5690,5527,2932,5705,9861,4343,5700,5528,284,5573,23112,5689,5693,673,2335,7094,5245,5713,84335,23239,5715,1847,9491,5581,5781,3717,145957,5717,2065,7314,6774,5686,1843,6709,6199,5694,5170,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,2886,84078,10197,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,STAT5B,PPP2R5B,PRKACA,CRKL,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,CDKN1B,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,NCK1,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,STAT6,PSMD3,STAT1,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,ANGPT1,PRKAR1A,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,PRKCE,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,STAT3,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,GRB7,KBTBD7,PSME3,AGO3
R-HSA-2160916	Hyaluronan uptake and degradation	0.219211355828167	-1.51771891946471	12	5	0.00219683655536028	2276	8202	3161,6548,3373,8372,2990	HMMR,SLC9A1,HYAL1,HYAL3,GUSB
R-HSA-203615	eNOS activation	0.219211355828167	-1.51771891946471	12	5	0.00219683655536028	2276	8202	10434,805,23564,857,3320	LYPLA1,CALM2,DDAH2,CAV1,HSP90AA1
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	0.219211355828167	-1.51771891946471	12	5	0.00219683655536028	2276	8202	1147,8517,64135,3551,8772	CHUK,IKBKG,IFIH1,IKBKB,FADD
R-HSA-70263	Gluconeogenesis	0.219233886691151	-1.51761614328736	31	11	0.00483304042179262	2276	8202	2597,5091,5230,4191,226,1468,5105,5224,2805,5566,6576	GAPDH,PC,PGK1,MDH2,ALDOA,SLC25A10,PCK1,PGAM2,GOT1,PRKACA,SLC25A1
R-HSA-162592	Integration of provirus	0.220569541782995	-1.51154225158195	9	4	0.00175746924428822	2276	8202	3159,5478,2547,7520	HMGA1,PPIA,XRCC6,XRCC5
R-HSA-167590	Nef Mediated CD4 Down-regulation	0.220569541782995	-1.51154225158195	9	4	0.00175746924428822	2276	8202	163,51606,1175,160	AP2B1,ATP6V1H,AP2S1,AP2A1
R-HSA-112411	MAPK1 (ERK2) activation	0.220569541782995	-1.51154225158195	9	4	0.00175746924428822	2276	8202	3717,7297,3569,5781	JAK2,TYK2,IL6,PTPN11
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	0.227288904005153	-1.48153336583455	61	20	0.00878734622144113	2276	8202	10163,5058,10152,10451,8936,4690,3326,10096,4627,10552,4641,998,55845,63916,8976,10097,3320,10109,147179,10006	WASF2,PAK1,ABI2,VAV3,WASF1,NCK1,HSP90AB1,ACTR3,MYH9,ARPC1A,MYO1C,CDC42,BRK1,ELMO2,WASL,ACTR2,HSP90AA1,ARPC2,WIPF2,ABI1
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding	0.227959311044296	-1.47858812628567	28	10	0.00439367311072056	2276	8202	10576,6950,5203,10383,7203,10574,10694,5201,10575,10381	CCT2,TCP1,PFDN4,TUBB4B,CCT3,CCT7,CCT8,PFDN1,CCT4,TUBB3
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.231438436974773	-1.46344137181627	78	25	0.0109841827768014	2276	8202	9439,6517,1024,1019,9442,10001,54797,10025,29079,55090,8202,112950,84246,6721,9441,23097,51586,5105,9862,6907,9443,9282,10891,5970,90390	MED23,SLC2A4,CDK8,CDK4,MED27,MED6,MED18,MED16,MED4,MED9,NCOA3,MED8,MED10,SREBF2,MED26,CDK19,MED15,PCK1,MED24,TBL1X,MED7,MED14,PPARGC1A,RELA,MED30
R-HSA-1227986	Signaling by ERBB2	0.232614482063846	-1.45837277916831	320	95	0.0417398945518453	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,5526,5566,805,5707,5687,5696,6464,5518,10193,5296,28956,11221,8503,1027,253260,10768,7414,64223,11140,7311,2931,208,842,5695,1742,55914,572,5529,817,5719,6233,5714,5709,4296,5527,2932,5690,5705,9861,4343,5700,5528,284,5573,23112,5689,5693,673,2335,7094,5245,5713,84335,23239,5715,1847,9491,5581,5781,3717,145957,5717,3320,2065,7314,5686,1843,6709,6199,5694,5170,5692,3164,5702,9101,5682,3845,5710,4140,5691,7316,369,2886,84078,10197,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,RNF41,PIK3R2,LAMTOR2,DUSP10,PIK3R3,CDKN1B,RICTOR,AHCYL1,VCL,MLST8,CDC37,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,ERBB2IP,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PPP2R5C,GSK3B,PSMB2,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,ANGPT1,PRKAR1A,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,PRKCE,PTPN11,JAK2,NRG4,PSMD11,HSP90AA1,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,PSMB4,NR4A1,PSMC3,USP8,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,GRB7,KBTBD7,PSME3,AGO3
R-HSA-187037	NGF signalling via TRKA from the plasma membrane	0.232782461555129	-1.45765090292533	355	105	0.0461335676625659	2276	8202	161742,10142,200734,5607,1848,2475,4763,5894,5604,1147,5526,5566,1399,805,5707,5696,6196,5687,6464,5518,5296,28956,1785,11221,8503,163,1027,253260,10768,7414,64223,7311,2931,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,4296,5527,2932,5690,5705,9861,4343,5700,1175,5528,284,5573,23112,5689,5693,673,2335,7094,5245,5713,5900,4205,84335,23239,5715,9252,1847,9491,5581,466,5781,3717,145957,5717,2065,5598,7314,6774,5686,1843,6709,6199,5694,5170,5692,7867,3164,5702,5682,3845,6016,5710,2002,4140,5691,7316,369,160,84078,10197,192669	SPRED1,AKAP9,SPRED2,MAP2K5,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,CRKL,CALM2,PSMD1,PSMB8,RPS6KA2,PSMA6,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DNM2,DUSP10,PIK3R3,AP2B1,CDKN1B,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PPP2R5C,GSK3B,PSMB2,PSMC5,PSMD6,MOV10,PSMC1,AP2S1,PPP2R5D,ANGPT1,PRKAR1A,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,RALGDS,MEF2A,AKT1S1,PHLPP1,PSMD9,RPS6KA5,DUSP5,PSMF1,PRKCE,ATF1,PTPN11,JAK2,NRG4,PSMD11,ERBB3,MAPK7,UBB,STAT3,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,PSMB4,MAPKAPK3,NR4A1,PSMC3,PSMA1,KRAS,RIT1,PSMD4,ELK1,MARK3,PSMB3,UBC,ARAF,AP2A1,KBTBD7,PSME3,AGO3
R-HSA-15869	Metabolism of nucleotides	0.245101770158082	-1.40608176628695	82	26	0.0114235500878735	2276	8202	7296,7083,204,2987,5471,7378,6240,1723,6241,3615,221264,79873,159,131870,1890,51292,654364,2618,5198,10606,1854,3614,30833,7372,11164,1716	TXNRD1,TK1,AK2,GUK1,PPAT,UPP1,RRM1,DHODH,RRM2,IMPDH2,AK9,NUDT18,ADSS,NUDT16,TYMP,GMPR2,NME1-NME2,GART,PFAS,PAICS,DUT,IMPDH1,NT5C,UMPS,NUDT5,DGUOK
R-HSA-389513	CTLA4 inhibitory signaling	0.246964822104128	-1.398509373128	22	8	0.00351493848857645	2276	8202	5170,5527,5529,5526,5518,5528,208,5781	PDPK1,PPP2R5C,PPP2R5E,PPP2R5B,PPP2R1A,PPP2R5D,AKT2,PTPN11
R-HSA-5334118	DNA methylation	0.252987771442026	-1.374414125644	62	20	0.00878734622144113	2276	8202	3015,723790,8367,85236,8350,3021,8363,8340,8368,8347,8360,8365,3012,8362,8364,3014,653604,128312,3017,8331	H2AFZ,HIST2H2AA4,HIST1H4E,HIST1H2BK,HIST1H3A,H3F3B,HIST1H4J,HIST1H2BL,HIST1H4L,HIST1H2BC,HIST1H4D,HIST1H4H,HIST1H2AE,HIST1H4K,HIST1H4C,H2AFX,HIST2H3D,HIST3H2BB,HIST1H2BD,HIST1H2AJ
R-HSA-177929	Signaling by EGFR	0.254799722997396	-1.3672774424221	336	99	0.0434973637961336	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,5526,5566,8027,30011,805,5707,5687,5696,6464,998,5518,5296,28956,11221,8503,163,1027,253260,10768,7414,64223,7311,2931,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,4296,5690,5527,2932,5705,9861,4343,5700,1175,5528,284,5573,23112,5689,5693,673,2335,7094,5245,5713,29924,84335,23239,5715,1847,9491,5581,5781,3717,145957,5717,2065,7314,10253,5686,1843,6709,6199,5694,5170,6868,5692,3164,2060,5702,5682,3845,5710,4140,5691,7316,369,160,84078,10197,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,STAM,SH3KBP1,CALM2,PSMD1,PSMA6,PSMB8,SHC1,CDC42,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,AP2B1,CDKN1B,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,AP2S1,PPP2R5D,ANGPT1,PRKAR1A,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,EPN1,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,PRKCE,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,SPRY2,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,ADAM17,PSMB4,NR4A1,EPS15,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,AP2A1,KBTBD7,PSME3,AGO3
R-HSA-1980145	Signaling by NOTCH2	0.255437313944968	-1.36477824603581	32	11	0.00483304042179262	2276	8202	4192,142678,3280,7311,51107,6233,3516,7314,9794,23385,7316	MDK,MIB2,HES1,UBA52,APH1A,RPS27A,RBPJ,UBB,MAML1,NCSTN,UBC
R-HSA-446219	Synthesis of substrates in N-glycan biosythesis	0.255851505856125	-1.36315805804922	52	17	0.00746924428822496	2276	8202	4351,4597,10825,6480,10020,26503,5373,29926,4758,5372,79947,6484,6675,57171,29925,6483,10559	MPI,MVD,NEU3,ST6GAL1,GNE,SLC17A5,PMM2,GMPPA,NEU1,PMM1,DHDDS,ST3GAL4,UAP1,DOLPP1,GMPPB,ST3GAL2,SLC35A1
R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.261178168328558	-1.34255246727612	312	92	0.0404217926186292	2276	8202	10163,161742,10142,200734,1848,8936,2475,4763,5894,5604,5526,5566,805,5707,5687,5696,6464,55845,1499,998,63916,5518,5296,28956,11221,253260,10768,7414,10006,64223,7311,4690,208,5695,1742,857,5529,817,5719,6233,5714,558,5709,4296,2185,5527,5690,1500,5705,9861,5700,5528,284,5689,5693,673,2335,3728,7094,1495,5245,5713,5715,1847,9491,3717,145957,5717,3320,2065,7314,9475,5686,6709,1843,5694,5170,5058,10152,10451,5692,7867,5702,5682,3845,5710,4140,5691,7316,369,84078,10197	WASF2,SPRED1,AKAP9,SPRED2,DUSP6,WASF1,MTOR,NF1,RAF1,MAP2K1,PPP2R5B,PRKACA,CALM2,PSMD1,PSMA6,PSMB8,SHC1,BRK1,CTNNB1,CDC42,ELMO2,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,RICTOR,AHCYL1,VCL,ABI1,MLST8,UBA52,NCK1,AKT2,PSMB7,DLG4,CAV1,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,AXL,PSMD3,MAP3K11,PTK2B,PPP2R5C,PSMB2,CTNND1,PSMC5,PSMD6,PSMC1,PPP2R5D,ANGPT1,PSMB1,PSMB5,BRAF,FN1,JUP,TLN1,CTNNA1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,JAK2,NRG4,PSMD11,HSP90AA1,ERBB3,UBB,ROCK2,PSMA5,SPTAN1,DUSP1,PSMB6,PDPK1,PAK1,ABI2,VAV3,PSMB4,MAPKAPK3,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,KBTBD7,PSME3
R-HSA-1236394	Signaling by ERBB4	0.261178168328558	-1.34255246727612	312	92	0.0404217926186292	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,6777,5526,805,5707,5687,5696,6464,5518,5296,28956,11221,8503,1027,253260,7414,64223,7311,2931,51107,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,25970,4296,5690,5527,2932,5705,9861,4343,5700,5528,23385,284,23112,5689,5693,673,2335,7094,5245,5713,84335,23239,5715,1847,9491,4734,5781,3717,145957,5717,2065,7314,5686,1843,6709,6199,5694,5170,6868,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,84078,10197,8945,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,STAT5B,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,CDKN1B,RICTOR,VCL,MLST8,UBA52,GSK3A,APH1A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,SH2B1,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,NCSTN,ANGPT1,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,NEDD4,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,ADAM17,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,KBTBD7,PSME3,BTRC,AGO3
R-HSA-390466	Chaperonin-mediated protein folding	0.266571121177564	-1.32211419976966	49	16	0.0070298769771529	2276	8202	10576,10383,26272,7203,10694,5201,10575,6950,5203,26190,22803,10574,83752,10381,84261,54461	CCT2,TUBB4B,FBXO4,CCT3,CCT8,PFDN1,CCT4,TCP1,PFDN4,FBXW2,XRN2,CCT7,LONP2,TUBB3,FBXW9,FBXW5
R-HSA-445355	Smooth Muscle Contraction	0.266880202412895	-1.32095540137044	29	10	0.00439367311072056	2276	8202	805,7170,7169,7094,800,7171,4637,7414,10627,140465	CALM2,TPM3,TPM2,TLN1,CALD1,TPM4,MYL6,VCL,MYL12A,MYL6B
R-HSA-162710	Synthesis of glycosylphosphatidylinositol (GPI)	0.268251455352356	-1.31583047212777	16	6	0.00263620386643234	2276	8202	5279,5277,84720,9487,5281,54872	PIGC,PIGA,PIGO,PIGL,PIGF,PIGG
R-HSA-1834941	STING mediated induction of host immune responses	0.268251455352356	-1.31583047212777	16	6	0.00263620386643234	2276	8202	51428,115004,6778,2547,23220,7520	DDX41,MB21D1,STAT6,XRCC6,DTX4,XRCC5
R-HSA-1369062	ABC transporters in lipid homeostasis	0.268251455352356	-1.31583047212777	16	6	0.00263620386643234	2276	8202	5824,21,5825,8504,10347,20	PEX19,ABCA3,ABCD3,PEX3,ABCA7,ABCA2
R-HSA-112122	ALKBH2 mediated reversal of alkylation damage	0.277493294314272	-1.28195851072087	1	1	0.000439367311072056	2276	8202	121642	ALKBH2
R-HSA-163316	Mitochondrial transcription termination	0.277493294314272	-1.28195851072087	1	1	0.000439367311072056	2276	8202	7978	MTERF1
R-HSA-162589	Reverse Transcription of HIV RNA	0.277493294314272	-1.28195851072087	1	1	0.000439367311072056	2276	8202	5478	PPIA
R-HSA-3359474	Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC	0.277493294314272	-1.28195851072087	1	1	0.000439367311072056	2276	8202	25974	MMACHC
R-HSA-162585	Uncoating of the HIV Virion	0.277493294314272	-1.28195851072087	1	1	0.000439367311072056	2276	8202	5478	PPIA
R-HSA-164525	Plus-strand DNA synthesis	0.277493294314272	-1.28195851072087	1	1	0.000439367311072056	2276	8202	5478	PPIA
R-HSA-164516	Minus-strand DNA synthesis	0.277493294314272	-1.28195851072087	1	1	0.000439367311072056	2276	8202	5478	PPIA
R-HSA-2466712	Biosynthesis of A2E, implicated in retinal degradation	0.277493294314272	-1.28195851072087	1	1	0.000439367311072056	2276	8202	222236	NAPEPLD
R-HSA-5467333	APC truncation mutants are not K63 polyubiquitinated	0.277493294314272	-1.28195851072087	1	1	0.000439367311072056	2276	8202	324	APC
R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	0.279713757953305	-1.27398849173471	13	5	0.00219683655536028	2276	8202	163,2535,1175,160,1213	AP2B1,FZD2,AP2S1,AP2A1,CLTC
R-HSA-4641265	Repression of WNT target genes	0.279713757953305	-1.27398849173471	13	5	0.00219683655536028	2276	8202	7091,1488,1499,7090,6934	TLE4,CTBP2,CTNNB1,TLE3,TCF7L2
R-HSA-73929	Base-Excision Repair, AP Site Formation	0.291442262070675	-1.23291336460911	10	4	0.00175746924428822	2276	8202	79661,6996,4913,4595	NEIL1,TDG,NTHL1,MUTYH
R-HSA-193692	Regulated proteolysis of p75NTR	0.291442262070675	-1.23291336460911	10	4	0.00175746924428822	2276	8202	6868,51107,5970,23385	ADAM17,APH1A,RELA,NCSTN
R-HSA-450341	Activation of the AP-1 family of transcription factors	0.291442262070675	-1.23291336460911	10	4	0.00175746924428822	2276	8202	3725,1386,2353,5601	JUN,ATF2,FOS,MAPK9
R-HSA-3323169	Defects in biotin (Btn) metabolism	0.302494156488018	-1.19569331909281	7	3	0.00131810193321617	2276	8202	5091,64087,56922	PC,MCCC2,MCCC1
R-HSA-199920	CREB phosphorylation	0.302494156488018	-1.19569331909281	7	3	0.00131810193321617	2276	8202	466,6196,9252	ATF1,RPS6KA2,RPS6KA5
R-HSA-435368	Zinc efflux and compartmentalization by the SLC30 family	0.302494156488018	-1.19569331909281	7	3	0.00131810193321617	2276	8202	7779,64924,55676	SLC30A1,SLC30A5,SLC30A6
R-HSA-3371599	Defective HLCS causes multiple carboxylase deficiency	0.302494156488018	-1.19569331909281	7	3	0.00131810193321617	2276	8202	5091,64087,56922	PC,MCCC2,MCCC1
R-HSA-71336	Pentose phosphate pathway (hexose monophosphate shunt)	0.302494156488018	-1.19569331909281	7	3	0.00131810193321617	2276	8202	25796,22934,5226	PGLS,RPIA,PGD
R-HSA-2214320	Anchoring fibril formation	0.302494156488018	-1.19569331909281	7	3	0.00131810193321617	2276	8202	1294,7092,3914	COL7A1,TLL1,LAMB3
R-HSA-164843	2-LTR circle formation	0.302494156488018	-1.19569331909281	7	3	0.00131810193321617	2276	8202	3159,2547,7520	HMGA1,XRCC6,XRCC5
R-HSA-2393930	Phosphate bond hydrolysis by NUDT proteins	0.302494156488018	-1.19569331909281	7	3	0.00131810193321617	2276	8202	131870,11164,79873	NUDT16,NUDT5,NUDT18
R-HSA-2142789	Ubiquinol biosynthesis	0.302494156488018	-1.19569331909281	7	3	0.00131810193321617	2276	8202	84274,57107,51004	COQ5,PDSS2,COQ6
R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.302494156488018	-1.19569331909281	7	3	0.00131810193321617	2276	8202	1499,4609,6934	CTNNB1,MYC,TCF7L2
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.303134778369038	-1.19357775927365	57	18	0.00790861159929701	2276	8202	142678,3280,6868,7311,1024,51107,10013,10014,7316,9759,6233,4609,3516,6907,9794,7314,23385,3066	MIB2,HES1,ADAM17,UBA52,CDK8,APH1A,HDAC6,HDAC5,UBC,HDAC4,RPS27A,MYC,RBPJ,TBL1X,MAML1,UBB,NCSTN,HDAC2
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.303134778369038	-1.19357775927365	57	18	0.00790861159929701	2276	8202	142678,3280,6868,7311,1024,51107,10013,10014,7316,9759,6233,4609,3516,6907,9794,7314,23385,3066	MIB2,HES1,ADAM17,UBA52,CDK8,APH1A,HDAC6,HDAC5,UBC,HDAC4,RPS27A,MYC,RBPJ,TBL1X,MAML1,UBB,NCSTN,HDAC2
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.303134778369038	-1.19357775927365	57	18	0.00790861159929701	2276	8202	142678,3280,6868,7311,1024,51107,10013,10014,7316,9759,6233,4609,3516,6907,9794,7314,23385,3066	MIB2,HES1,ADAM17,UBA52,CDK8,APH1A,HDAC6,HDAC5,UBC,HDAC4,RPS27A,MYC,RBPJ,TBL1X,MAML1,UBB,NCSTN,HDAC2
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.303134778369038	-1.19357775927365	57	18	0.00790861159929701	2276	8202	142678,3280,6868,7311,1024,51107,10013,10014,7316,9759,6233,4609,3516,6907,9794,7314,23385,3066	MIB2,HES1,ADAM17,UBA52,CDK8,APH1A,HDAC6,HDAC5,UBC,HDAC4,RPS27A,MYC,RBPJ,TBL1X,MAML1,UBB,NCSTN,HDAC2
R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.303134778369038	-1.19357775927365	57	18	0.00790861159929701	2276	8202	142678,3280,6868,7311,1024,51107,10013,10014,7316,9759,6233,4609,3516,6907,9794,7314,23385,3066	MIB2,HES1,ADAM17,UBA52,CDK8,APH1A,HDAC6,HDAC5,UBC,HDAC4,RPS27A,MYC,RBPJ,TBL1X,MAML1,UBB,NCSTN,HDAC2
R-HSA-2028269	Signaling by Hippo	0.307611295876971	-1.17891831940797	20	7	0.00307557117750439	2276	8202	51421,26524,7082,261734,60485,7531,1856	AMOTL2,LATS2,TJP1,NPHP4,SAV1,YWHAE,DVL2
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	0.307668563196421	-1.17873216893101	30	10	0.00439367311072056	2276	8202	142678,6868,7311,51107,6233,23220,7314,23385,8650,7316	MIB2,ADAM17,UBA52,APH1A,RPS27A,DTX4,UBB,NCSTN,NUMB,UBC
R-HSA-111448	Activation of NOXA and translocation to mitochondria	0.308844095629993	-1.17491867429675	4	2	0.000878734622144112	2276	8202	5366,7157	PMAIP1,TP53
R-HSA-6783984	Glycine degradation	0.308844095629993	-1.17491867429675	4	2	0.000878734622144112	2276	8202	1738,2653	DLD,GCSH
R-HSA-5579026	Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	0.308844095629993	-1.17491867429675	4	2	0.000878734622144112	2276	8202	112812,2232	FDX1L,FDXR
R-HSA-1369007	Mitochondrial ABC transporters	0.308844095629993	-1.17491867429675	4	2	0.000878734622144112	2276	8202	11194,10058	ABCB8,ABCB6
R-HSA-110381	Resolution of AP sites via the single-nucleotide replacement pathway	0.308844095629993	-1.17491867429675	4	2	0.000878734622144112	2276	8202	5423,7515	POLB,XRCC1
R-HSA-196819	Vitamin B1 (thiamin) metabolism	0.308844095629993	-1.17491867429675	4	2	0.000878734622144112	2276	8202	10560,27010	SLC19A2,TPK1
R-HSA-165158	Activation of AKT2	0.308844095629993	-1.17491867429675	4	2	0.000878734622144112	2276	8202	5170,208	PDPK1,AKT2
R-HSA-75944	Transcription from mitochondrial promoters	0.308844095629993	-1.17491867429675	4	2	0.000878734622144112	2276	8202	64216,7978	TFB2M,MTERF1
R-HSA-1280215	Cytokine Signaling in Immune system	0.310100174711729	-1.17085988947141	539	155	0.0681019332161687	2276	8202	23291,23511,4763,85363,6777,329,55128,805,5707,5696,9775,5296,5971,11221,3660,9972,3459,1977,25820,7311,3841,11274,7335,5719,6233,5714,25970,80263,4296,2185,5690,5527,5705,5528,5700,284,8086,3122,5689,3636,5693,2335,1958,7094,3133,3134,5245,5713,5715,1847,129401,23165,8771,4927,8878,10379,3107,5686,1974,5702,5682,3845,1982,5691,369,23636,7534,2537,9818,161742,200734,10142,1848,5894,5604,1147,5526,5566,5495,1399,5687,8651,6464,5518,55746,5300,28956,3551,8503,103,4791,5970,7414,4215,330,8767,5695,1742,9631,8021,7297,6773,3669,8517,817,5529,5903,5709,6772,9861,10454,7334,673,257397,7186,8480,53371,51191,8672,567,51447,9491,4734,3105,7341,5770,5781,10612,3717,145957,5717,2065,6885,7314,6774,3837,1843,6709,5694,6868,4502,5692,1973,23087,246330,5710,4140,7316,7726,3840,5608,3569,84078,10197,8945	FBXW11,NUP188,NF1,TRIM5,STAT5B,BIRC2,TRIM68,CALM2,PSMD1,PSMB8,EIF4A3,PIK3R2,RELB,DUSP10,IRF2,NUP153,IFNGR1,EIF4E,ARIH1,UBA52,KPNA5,USP18,UBE2V1,PSMD13,RPS27A,PSMD8,SH2B1,TRIM45,MAP3K11,PTK2B,PSMB2,PPP2R5C,PSMC5,PPP2R5D,PSMC1,ANGPT1,AAAS,HLA-DRA,PSMB1,INPPL1,PSMB5,FN1,EGR1,TLN1,HLA-E,HLA-F,PHB,PSMD7,PSMD9,DUSP5,NUP35,NUP205,TNFRSF6B,NUP88,SQSTM1,IRF9,HLA-C,PSMA5,EIF4A2,PSMC3,PSMA1,KRAS,EIF4G2,PSMB3,ARAF,NUP62,YWHAZ,IFI6,NUP58,SPRED1,SPRED2,AKAP9,DUSP6,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,PPM1B,CRKL,PSMA6,SOCS1,SHC1,PPP2R1A,NUP133,PIN1,LAMTOR2,IKBKB,PIK3R3,ADAR,NFKB2,RELA,VCL,MAP3K3,BIRC3,RIPK2,PSMB7,DLG4,NUP155,NUP214,TYK2,STAT2,ISG20,IKBKG,CAMK2D,PPP2R5E,RANBP2,PSMD3,STAT1,PSMD6,TAB1,UBE2N,BRAF,TAB3,TRAF2,RAE1,NUP54,HERC5,EIF4G3,B2M,IP6K2,PSMF1,NEDD4,HLA-A,SUMO1,PTPN1,PTPN11,TRIM3,JAK2,NRG4,PSMD11,ERBB3,MAP3K7,UBB,STAT3,KPNB1,DUSP1,SPTAN1,PSMB6,ADAM17,MT2A,PSMB4,EIF4A1,TRIM35,PELI3,PSMD4,MARK3,UBC,TRIM26,KPNA4,MAP2K6,IL6,KBTBD7,PSME3,BTRC
R-HSA-168256	Immune System	0.319560659824256	-1.14080816458054	1371	388	0.170474516695958	2276	8202	23511,85363,5589,6890,6777,9867,51728,805,5707,63916,6786,10193,8907,1785,54778,163,3660,9972,10097,10411,5094,26259,64223,140739,7311,208,842,3109,572,64145,5719,6233,5714,7174,25970,3688,4296,5527,2932,8086,51433,3146,5689,3636,1958,5440,23480,3133,171568,4012,30849,23327,80196,5715,4641,129401,5581,3725,811,966,8878,5601,23545,5598,54926,10112,25847,7867,5702,1974,11069,2002,4591,10425,5691,7520,22872,24137,160,51626,10109,9604,64135,9818,200734,90933,161742,1848,79671,523,23304,5894,10096,4627,1147,598,162,5495,5566,8411,1399,6464,79876,28956,10628,835,1027,103,51434,253260,64219,1386,5970,1639,10484,2931,8767,3326,1742,535,8697,7297,6773,56658,3669,3108,3796,5529,8517,817,1650,23608,2547,6772,9474,7334,55521,5573,55593,23112,6396,7184,673,7186,8672,51191,567,80143,9354,84335,51447,9252,9491,4734,3105,7341,661,5781,6047,26046,145957,89910,2065,6885,7314,80329,5694,6709,5170,10451,5289,4502,7128,5609,7319,29882,1973,5710,3832,2353,4140,7316,8772,51128,10671,3569,51444,51752,1062,23376,10197,170506,8945,23291,9820,8936,4763,55585,11004,55128,329,30011,5606,6196,5696,1499,998,9775,51343,5296,10393,51619,5971,23295,11221,3835,55703,3459,1977,529,147179,25820,1604,3841,4690,11274,3309,868,9140,7335,1525,1213,80263,5690,2185,7320,51130,5705,5700,5528,284,3122,11258,7323,10120,5693,2335,9871,7094,26272,3134,5245,5713,140462,3831,4205,29127,84516,23239,1847,23165,8771,4927,7408,829,8139,10379,3107,51606,90678,9114,5686,10621,5058,10152,51295,10892,5682,6921,3845,10552,1982,996,369,51082,5434,23636,7534,27338,2537,192669,10163,10142,1540,7317,84231,2475,55284,8655,5604,5526,821,5687,55845,8651,5518,197131,55746,5300,3551,8503,10768,4791,7414,10006,54476,4215,10802,79465,51428,330,115004,7879,991,5695,9631,8021,23352,837,725,5903,7336,5709,8976,6778,10533,9861,10454,4343,1175,1781,9320,9903,25831,257397,5966,8480,10540,53371,8887,24145,466,5770,27252,9632,51164,51465,10612,3717,5717,3320,6774,9730,3837,1843,6199,6868,5692,3164,6502,7328,23087,246330,55236,11128,10910,3840,7726,51382,5608,8453,7322,84078,23220,528,164,11065,63891	NUP188,TRIM5,PRKCSH,TAP1,STAT5B,PJA2,POLR3K,CALM2,PSMD1,ELMO2,STIM1,RNF41,AP1M1,DNM2,RNF111,AP2B1,IRF2,NUP153,ACTR2,RAPGEF3,PCBP2,FBXW8,MLST8,UBE2F,UBA52,AKT2,CASP9,HLA-DMB,BAD,RBSN,PSMD13,RPS27A,PSMD8,TPP2,SH2B1,ITGB1,MAP3K11,PPP2R5C,GSK3B,AAAS,ANAPC5,HMGB1,PSMB1,INPPL1,EGR1,POLR2K,SEC61G,HLA-E,POLR3H,LNPEP,PIK3R4,NEDD4L,RNF34,PSMD9,MYO1C,NUP35,PRKCE,JUN,CALR,CD59,SQSTM1,MAPK9,ATP6V0A2,MAPK7,UBE2R2,KIF20A,ANAPC13,MAPKAPK3,PSMC3,EIF4A2,RAPGEF4,ELK1,TRIM37,ARIH2,PSMB3,XRCC5,SEC31A,KIF4A,AP2A1,DYNC2LI1,ARPC2,RNF14,IFIH1,NUP58,SPRED2,TRIM41,SPRED1,DUSP6,NLRX1,ATP6V1A,UBR2,RAF1,ACTR3,MYH9,CHUK,BCL2L1,AP1B1,PPM1B,PRKACA,EEA1,CRKL,SHC1,UBA5,LAMTOR2,TXNIP,CASP2,CDKN1B,ADAR,ANAPC7,RICTOR,PJA1,ATF2,RELA,DCTN1,SEC23A,GSK3A,RIPK2,HSP90AB1,DLG4,ATP6V0A1,CDC23,TYK2,STAT2,TRIM39,ISG20,HLA-DMA,KIF2A,PPP2R5E,IKBKG,CAMK2D,DDOST,MKRN1,XRCC6,STAT1,ATG5,UBE2N,TRIM36,PRKAR1A,OTUD5,TNRC6B,SEC13,HSP90B1,BRAF,TRAF2,EIF4G3,HERC5,B2M,SIKE1,UBE4A,AKT1S1,IP6K2,RPS6KA5,PSMF1,NEDD4,HLA-A,SUMO1,POLR3D,PTPN11,RNF4,LTN1,NRG4,UBE3B,ERBB3,MAP3K7,UBB,ULBP1,PSMB6,SPTAN1,PDPK1,VAV3,PIK3C3,MT2A,TNFAIP3,MAP2K7,UBE2A,ANAPC2,EIF4A1,PSMD4,KIF11,FOS,MARK3,UBC,FADD,SAR1B,DCTN6,IL6,RNF138,ERAP1,CENPE,UFL1,PSME3,DHX36,BTRC,FBXW11,CUL7,WASF1,NF1,UBE2Q1,KIF2C,TRIM68,BIRC2,SH3KBP1,MAP2K3,RPS6KA2,PSMB8,CTNNB1,CDC42,EIF4A3,FZR1,PIK3R2,ANAPC10,UBE2D4,RELB,MGRN1,DUSP10,KIF22,POLR3B,IFNGR1,EIF4E,ATP6V1E1,WIPF2,ARIH1,CD55,KPNA5,NCK1,USP18,HSPA5,CBLB,ATG12,UBE2V1,CXADR,CLTC,TRIM45,PSMB2,PTK2B,UBE2B,ASB3,PSMC5,PSMC1,PPP2R5D,ANGPT1,HLA-DRA,DCTN3,UBE2D3,ACTR1B,PSMB5,FN1,SEC24D,TLN1,FBXO4,HLA-F,PHB,PSMD7,ASB9,KLC1,MEF2A,RACGAP1,DCTN5,PHLPP1,DUSP5,NUP205,TNFRSF6B,NUP88,VASP,CAPZA1,GAN,IRF9,HLA-C,ATP6V1H,LRSAM1,ATP6V0D1,PSMA5,POLR3F,PAK1,ABI2,ECSIT,MALT1,PSMA1,TCEB1,KRAS,ARPC1A,EIF4G2,CDC27,ARAF,POLR1D,POLR2E,NUP62,YWHAZ,UBE2S,IFI6,AGO3,WASF2,AKAP9,CYLD,UBA1,TRAF7,MTOR,UBE2W,DYNLL1,MAP2K1,PPP2R5B,CANX,PSMA6,BRK1,SOCS1,PPP2R1A,UBR1,NUP133,PIN1,IKBKB,PIK3R3,AHCYL1,NFKB2,VCL,ABI1,RNF216,MAP3K3,SEC24A,ULBP3,DDX41,BIRC3,MB21D1,RAB7A,CDC20,PSMB7,NUP155,NUP214,UBR4,CASP4,C4BPB,RANBP2,UBE2V2,PSMD3,WASL,STAT6,ATG7,PSMD6,TAB1,MOV10,AP2S1,DYNC1I2,TRIP12,KLHL21,HECTD1,TAB3,REL,RAE1,DCTN2,NUP54,TAX1BP1,PANX1,ATF1,PTPN1,KLHL20,SEC24C,DCTN4,UBE2J1,TRIM3,JAK2,PSMD11,HSP90AA1,STAT3,VPRBP,KPNB1,DUSP1,RPS6KB2,ADAM17,PSMB4,NR4A1,SKP2,UBE2H,TRIM35,PELI3,UBA6,POLR3A,SUGT1,KPNA4,TRIM26,ATP6V1D,MAP2K6,CUL2,UBE2D2,KBTBD7,DTX4,ATP6V1C1,AP1G1,UBE2C,RNF123
R-HSA-437239	Recycling pathway of L1	0.323186608834679	-1.12952538625459	27	9	0.00395430579964851	2276	8202	24137,6196,1808,160,1785,163,9252,1175,8650	KIF4A,RPS6KA2,DPYSL2,AP2A1,DNM2,AP2B1,RPS6KA5,AP2S1,NUMB
R-HSA-432142	Platelet sensitization by LDL	0.324145642205547	-1.12656235121042	17	6	0.00263620386643234	2276	8202	5527,5529,5526,5518,5528,5781	PPP2R5C,PPP2R5E,PPP2R5B,PPP2R1A,PPP2R5D,PTPN11
R-HSA-382556	ABC-family proteins mediated transport	0.324503928893892	-1.12545763538003	44	14	0.00615114235500879	2276	8202	5824,10058,21,8894,10257,1968,5825,8504,89845,20,11194,23,10347,10351	PEX19,ABCB6,ABCA3,EIF2S2,ABCC4,EIF2S3,ABCD3,PEX3,ABCC10,ABCA2,ABCB8,ABCF1,ABCA7,ABCA8
R-HSA-1980143	Signaling by NOTCH1	0.33805544598542	-1.08454535557545	72	22	0.00966608084358524	2276	8202	7091,142678,3280,6868,7311,1024,51107,7090,10013,10014,7316,9759,6233,4609,23220,6907,3516,7314,9794,23385,8650,3066	TLE4,MIB2,HES1,ADAM17,UBA52,CDK8,APH1A,TLE3,HDAC6,HDAC5,UBC,HDAC4,RPS27A,MYC,DTX4,TBL1X,RBPJ,UBB,MAML1,NCSTN,NUMB,HDAC2
R-HSA-109704	PI3K Cascade	0.339592222842484	-1.08000972574214	79	24	0.0105448154657293	2276	8202	5170,5564,5289,1975,2475,208,5565,5562,30849,5571,84335,6009,7248,51422,5296,28956,389541,6194,5781,5494,81617,6198,1977,64223	PDPK1,PRKAB1,PIK3C3,EIF4B,MTOR,AKT2,PRKAB2,PRKAA1,PIK3R4,PRKAG1,AKT1S1,RHEB,TSC1,PRKAG2,PIK3R2,LAMTOR2,LAMTOR4,RPS6,PTPN11,PPM1A,CAB39L,RPS6KB1,EIF4E,MLST8
R-HSA-933542	TRAF6 mediated NF-kB activation	0.340341079490131	-1.0778069892447	24	8	0.00351493848857645	2276	8202	3146,8517,7186,3551,1147,4791,5970,64135	HMGB1,IKBKG,TRAF2,IKBKB,CHUK,NFKB2,RELA,IFIH1
R-HSA-68884	Mitotic Telophase/Cytokinesis	0.342870184658991	-1.07040337383614	14	5	0.00219683655536028	2276	8202	25836,10274,10112,10726,8243	NIPBL,STAG1,KIF20A,NUDC,SMC1A
R-HSA-5684996	MAPK1/MAPK3 signaling	0.348666423372346	-1.05363962081048	234	68	0.0298769771528998	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,7297,983,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,5781,3717,145957,5717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,3569,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,TYK2,CDK1,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,IL6,KBTBD7,PSME3
R-HSA-1430728	Metabolism	0.350574363621314	-1.0481824306137	1691	476	0.209138840070299	2276	8202	23511,4712,5837,5565,27242,27249,10554,51686,10001,2639,25942,3163,8867,51312,805,9997,6484,1890,5707,1490,6721,517,158584,55471,1785,9972,1836,10411,4705,1738,152926,5160,2954,7311,7378,2788,6609,2271,5257,81894,79143,51170,23564,79017,5198,5719,25915,6233,112812,5714,226,9377,7388,6483,9282,8086,8704,10005,5689,4729,3636,4594,4329,1718,26229,30849,6240,81579,54205,51477,5715,129401,374291,4507,55512,51763,5298,6307,783,10476,51582,9862,1537,200576,2771,55967,5261,5631,64087,2222,6611,3156,3992,9415,5625,54704,594,4259,9807,5702,11069,2274,3615,6616,8394,9517,4548,5691,1528,55361,159,51292,8202,51422,119391,51586,47,29078,7372,5224,55627,2101,55748,1717,9818,686,2582,27304,9374,6517,1728,83990,10858,5166,55500,521,27158,83440,5566,253558,10560,2783,51293,1040,4709,80308,440,9110,1854,65263,134429,30833,4082,5256,9572,6820,90390,2879,8904,10484,2597,23597,1350,5163,5208,6303,1353,5209,55788,10025,4701,221264,6392,221,23097,10400,5500,784,9575,5573,2710,4837,51141,6391,593,10825,84245,1734,1723,8884,51447,506,10654,9491,10682,2937,27430,3157,10606,2232,1468,10434,1349,2068,7314,4696,3613,55856,5694,58478,55163,9439,10632,5289,7083,10678,6470,2987,29968,56895,3939,51647,5710,7316,51128,654364,3033,5091,5230,51,4802,10128,4725,57678,10197,10101,384,79944,51204,7381,7358,91012,56922,162466,6382,51241,1632,4552,1595,5696,60496,6821,5034,5296,23446,7385,3032,231,3373,4731,4700,4720,285521,1545,8034,9442,10087,56267,6241,25870,857,1743,93100,10327,2744,10555,3638,10855,59345,8942,5690,200895,10891,5705,5700,9054,5528,1340,80025,5693,50515,204,9871,79993,84803,5713,427,51070,79873,23165,55090,1119,8659,6945,4927,112950,84246,2356,4708,5105,6548,5805,29920,9443,5832,6309,224,5686,23309,337876,516,85465,5471,262,2629,5682,3295,4682,144193,55697,5226,26035,131870,8396,9167,2224,6566,23636,3145,6907,498,57107,65220,11112,25974,8802,58472,7360,4191,7351,10162,64900,51079,54539,9453,5424,29079,7386,5164,3422,5687,9441,84987,55746,5518,2820,1431,8503,2997,2805,10768,27063,10558,84188,326625,2787,2760,1491,10802,25796,55312,84274,1081,27089,4597,5695,57546,9631,2739,514,4967,11238,8021,64850,27010,513,50,5903,5743,8372,2542,210,22937,8976,5709,406,126328,4694,4128,22908,9861,56848,1716,4713,5723,22934,55191,10295,6652,8480,645,53371,682,54797,3633,51004,373156,4723,64768,883,2618,4520,2644,1337,9632,253430,4728,5717,51764,501,11164,3320,10728,1629,3837,6576,6667,7296,3161,1455,60481,1373,5692,1024,51300,2990,2729,7003,25830,50640,9551,92579,5498,3029,4758,5467,201164,80765,9,1351,3614,3420,64801,8310,2653,5130	NUP188,NDUFB6,PYGM,PRKAB2,TNFRSF21,MMADHC,AGPAT1,OAZ3,MED6,GCDH,SIN3A,HMOX2,SYNJ1,SLC25A37,CALM2,SCO2,ST3GAL4,TYMP,PSMD1,CTGF,SREBF2,ATP5G2,FAAH2,NDUFAF7,DNM2,NUP153,SLC26A2,RAPGEF3,NDUFA10,DLD,PPM1K,PDHA1,GSTZ1,UBA52,UPP1,GNG7,SMPD1,FH,PHKB,SLC25A28,MBOAT7,HSD17B11,DDAH2,GGCT,PFAS,PSMD13,NDUFAF3,RPS27A,FDX1L,PSMD8,ALDOA,COX5A,UQCRH,ST3GAL2,MED14,AAAS,B4GALT2,ACOT8,PSMB1,NDUFV2,INPPL1,MUT,ALDH6A1,DHCR24,B3GAT3,PIK3R4,RRM1,PLA2G12A,CYCS,ISYNA1,PSMD9,NUP35,NDUFS7,MTAP,SMPD3,INPP5K,PI4KB,MSMO1,CACNB2,ATP5H,AZIN1,MED24,CYC1,PIKFYVE,GNAI2,NDUFA12,PHKG2,PRPS1,MCCC2,FDFT1,SMS,HMGCR,FADS1,FADS2,PRODH,PDP1,BCKDHB,MGST3,IP6K1,PSMC3,RAPGEF4,FHL2,IMPDH2,SNAP25,PIP5K1A,SPTLC2,MTR,PSMB3,CYB5A,PI4K2A,ADSS,GMPR2,NCOA3,PRKAG2,GSTO2,MED15,ACLY,NDUFAF4,UMPS,PGAM2,SMPD4,ESRRA,CNDP2,DHCR7,NUP58,BTD,GALE,MOCS3,PPT2,SLC2A4,NQO1,BRIP1,CYP46A1,PDK4,ETNK1,ATP5I,NDOR1,ADPGK,PRKACA,LCLAT1,SLC19A2,GNB2,CD320,CDS1,NDUFB3,FLAD1,ASNS,MTMR4,DUT,PYCRL,STARD4,NT5C,MARCKS,PHKA2,NR1D1,SULT2B1,MED30,GPX4,CPNE1,SEC23A,GAPDH,ACOT9,COX7C,PDK1,PFKFB2,SAT1,COX11,PFKFB3,LMBRD1,MED16,NDUFA7,AK9,SDHD,ALDH3B1,CDK19,PEMT,PPP1CB,CACNB3,CLOCK,PRKAR1A,GK,NNMT,INSIG2,SDHC,BCKDHA,NEU3,MRI1,DIO2,DHODH,SLC5A6,IP6K2,ATP5B,PMVK,PSMF1,EBP,GSS,MAT2B,HMGCS1,PAICS,FDXR,SLC25A10,LYPLA1,COX7B,ERCC2,UBB,NDUFA3,IMPA2,ACOT13,PSMB6,ENOPH1,PNPO,MED23,ATP5L,PIK3C3,TK1,B3GNT2,SHMT1,GUK1,PSAT1,AGPAT4,LDHA,FAM96B,PSMD4,UBC,SAR1B,NME1-NME2,HADH,PC,PGK1,ACOX1,NFYC,LRPPRC,NDUFS5,GPAM,PSME3,NUBP2,ARG2,L2HGDH,TACO1,UQCRB,UGDH,CERS5,MCCC1,PHOSPHO1,SDC1,COX16,ECI1,MTRR,CYP51A1,PSMB8,AASDHPPT,SUOX,P4HB,PIK3R2,SLC44A1,UQCRC2,HADHB,AKR1B1,HYAL1,NDUFV3,NDUFA6,NDUFS2,COX18,CYP1B1,SLC25A16,MED27,COL4A3BP,CCBL2,RRM2,SUMF2,CAV1,DLST,NAPRT,AKR1A1,GLS,AGPAT2,INSIG1,HPSE,GNB4,KYNU,PSMB2,DHFRL1,PPARGC1A,PSMC5,PSMC1,NFS1,PPP2R5D,COX6B1,PANK2,PSMB5,CHST11,AK2,SEC24D,ELOVL7,GPAT3,PSMD7,ASAH1,NOSIP,NUDT18,NUP205,MED9,CHKA,ALDH4A1,MLX,NUP88,MED8,MED10,FPGS,NDUFB2,PCK1,SLC9A1,PTS,PYCR2,MED7,ALDH18A1,SC5D,ALDH3A2,PSMA5,SIN3B,CHSY3,ATP5G1,EPT1,PPAT,AMD1,GBA,PSMA1,HSD17B4,NUBP1,AMDHD1,VAC14,PGD,GLCE,NUDT16,PIP4K2B,COX7A2L,FDPS,SLC16A1,NUP62,HMBS,TBL1X,ATP5A1,PDSS2,NADK,HIBADH,MMACHC,SUCLG1,SQRDL,UGP2,MDH2,UCP2,LPCAT3,LPIN3,NDUFA13,NDUFB11,GGPS1,POLD1,MED4,UQCRFS1,PDK2,IDI1,PSMA6,MED26,COX14,NUP133,PPP2R1A,GPD2,CS,PIK3R3,GYS1,GOT1,AHCYL1,ANKRD1,SPTLC1,FAR1,MMAB,GNG5,GM2A,CTH,SEC24A,PGLS,RFK,COQ5,CGA,UQCRQ,MVD,PSMB7,PDP2,NUP155,GLO1,ATP5E,OGDH,CA5B,NUP214,ETNPPL,TPK1,ATP5D,ACO2,RANBP2,PTGS2,HYAL3,SLC37A4,ALAD,SCAP,WASL,PSMD3,ARNTL,NDUFA11,NDUFA1,MAOA,SACM1L,PSMD6,SPHK2,DGUOK,NDUFB7,PSPH,RPIA,NADSYN1,BCKDK,SORD,RAE1,BLVRB,NUP54,BSG,MED18,INPP5B,COQ6,GSTK1,NDUFV1,IPPK,CCBL1,GART,MTF1,GCHFR,COX6A1,SEC24C,IPMK,NDUFS8,PSMD11,GNG13,ALDH7A1,NUDT5,HSP90AA1,PTGES3,DBT,KPNB1,SLC25A1,SP1,TXNRD1,HMMR,CSNK1G2,ELOVL5,CPS1,PSMB4,CDK8,TIMMDC1,GUSB,GCLC,TEAD1,SULT4A1,PNPLA8,ATP5J2,G6PC3,PPOX,HAGH,NEU1,PPARD,PLD6,STARD5,NAT1,COX8A,IMPDH1,IDH3B,ARV1,ACOX3,GCSH,PCYT1A
R-HSA-389357	CD28 dependent PI3K/Akt signaling	0.359536863858398	-1.02293856505197	21	7	0.00307557117750439	2276	8202	5170,8503,253260,2475,208,5296,64223	PDPK1,PIK3R3,RICTOR,MTOR,AKT2,PIK3R2,MLST8
R-HSA-5621575	CD209 (DC-SIGN) signaling	0.359536863858398	-1.02293856505197	21	7	0.00307557117750439	2276	8202	5971,5058,3845,5566,9252,5970,5894	RELB,PAK1,KRAS,PRKACA,RPS6KA5,RELA,RAF1
R-HSA-5620916	VxPx cargo-targeting to cilium	0.359536863858398	-1.02293856505197	21	7	0.00307557117750439	2276	8202	9727,55770,4218,8729,8766,378,60412	RAB11FIP3,EXOC2,RAB8A,GBF1,RAB11A,ARF4,EXOC4
R-HSA-499943	Synthesis and interconversion of nucleotide di- and triphosphates	0.359536863858398	-1.02293856505197	21	7	0.00307557117750439	2276	8202	7296,6241,221264,204,654364,2987,6240	TXNRD1,RRM2,AK9,AK2,NME1-NME2,GUK1,RRM1
R-HSA-1912422	Pre-NOTCH Expression and Processing	0.359652735422132	-1.02261633690837	45	14	0.00615114235500879	2276	8202	3725,595,23112,6484,488,7157,1871,6400,3516,5870,9794,4343,192669,10959	JUN,CCND1,TNRC6B,ST3GAL4,ATP2A2,TP53,E2F3,SEL1L,RBPJ,RAB6A,MAML1,MOV10,AGO3,TMED2
R-HSA-194138	Signaling by VEGF	0.362519110819383	-1.01467808657529	320	92	0.0404217926186292	2276	8202	10163,161742,10142,200734,1848,8936,2475,4763,5894,5604,5526,5566,805,5707,5687,5696,6464,55845,1499,998,63916,5518,5296,28956,11221,253260,10768,7414,10006,64223,7311,4690,208,5695,1742,857,5529,817,5719,6233,5714,558,5709,4296,2185,5527,5690,1500,5705,9861,5700,5528,284,5689,5693,673,2335,3728,7094,1495,5245,5713,5715,1847,9491,3717,145957,5717,3320,2065,7314,9475,5686,6709,1843,5694,5170,5058,10152,10451,5692,7867,5702,5682,3845,5710,4140,5691,7316,369,84078,10197	WASF2,SPRED1,AKAP9,SPRED2,DUSP6,WASF1,MTOR,NF1,RAF1,MAP2K1,PPP2R5B,PRKACA,CALM2,PSMD1,PSMA6,PSMB8,SHC1,BRK1,CTNNB1,CDC42,ELMO2,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,RICTOR,AHCYL1,VCL,ABI1,MLST8,UBA52,NCK1,AKT2,PSMB7,DLG4,CAV1,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,AXL,PSMD3,MAP3K11,PTK2B,PPP2R5C,PSMB2,CTNND1,PSMC5,PSMD6,PSMC1,PPP2R5D,ANGPT1,PSMB1,PSMB5,BRAF,FN1,JUP,TLN1,CTNNA1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,JAK2,NRG4,PSMD11,HSP90AA1,ERBB3,UBB,ROCK2,PSMA5,SPTAN1,DUSP1,PSMB6,PDPK1,PAK1,ABI2,VAV3,PSMB4,MAPKAPK3,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,KBTBD7,PSME3
R-HSA-5654741	Signaling by FGFR3	0.363876352151853	-1.01094116094427	313	90	0.0395430579964851	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,5526,5566,805,5707,5687,5696,6464,5518,5296,28956,11221,8503,1027,253260,10768,7414,64223,7311,2931,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,4296,5690,5527,2932,5705,9861,4343,5700,5528,284,5573,23112,5689,5693,673,2335,7094,5245,5713,84335,23239,5715,1847,9491,5581,5781,3717,145957,5717,2065,7314,10253,5686,1843,6709,6199,5694,5170,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,84078,10197,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,CDKN1B,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,ANGPT1,PRKAR1A,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,PRKCE,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,SPRY2,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,KBTBD7,PSME3,AGO3
R-HSA-5654743	Signaling by FGFR4	0.363876352151853	-1.01094116094427	313	90	0.0395430579964851	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,5526,5566,805,5707,5687,5696,6464,5518,5296,28956,11221,8503,1027,253260,10768,7414,64223,7311,2931,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,4296,5690,5527,2932,5705,9861,4343,5700,5528,284,5573,23112,5689,5693,673,2335,7094,5245,5713,84335,23239,5715,1847,9491,5581,5781,3717,145957,5717,2065,7314,10253,5686,1843,6709,6199,5694,5170,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,84078,10197,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,CDKN1B,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,ANGPT1,PRKAR1A,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,PRKCE,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,SPRY2,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,KBTBD7,PSME3,AGO3
R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.364608853886647	-1.00893013319631	11	4	0.00175746924428822	2276	8202	157570,114799,10274,8243	ESCO2,ESCO1,STAG1,SMC1A
R-HSA-1855183	Synthesis of IP2, IP, and Ins in the cytosol	0.364608853886647	-1.00893013319631	11	4	0.00175746924428822	2276	8202	51477,3633,8867,3613	ISYNA1,INPP5B,SYNJ1,IMPA2
R-HSA-196807	Nicotinate metabolism	0.364608853886647	-1.00893013319631	11	4	0.00175746924428822	2276	8202	55191,5743,93100,65220	NADSYN1,PTGS2,NAPRT,NADK
R-HSA-164952	The role of Nef in HIV-1 replication and disease pathogenesis	0.368294276212992	-0.998872996751551	28	9	0.00395430579964851	2276	8202	163,567,162,51606,164,1175,160,3105,8907	AP2B1,B2M,AP1B1,ATP6V1H,AP1G1,AP2S1,AP2A1,HLA-A,AP1M1
R-HSA-5654716	Downstream signaling of activated FGFR4	0.371382005583896	-0.990524081469118	310	89	0.039103690685413	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,5526,5566,805,5707,5687,5696,6464,5518,5296,28956,11221,8503,1027,253260,10768,7414,64223,7311,2931,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,4296,5690,5527,2932,5705,9861,4343,5700,5528,284,5573,23112,5689,5693,673,2335,7094,5245,5713,84335,23239,5715,1847,9491,5581,5781,3717,145957,5717,2065,7314,5686,1843,6709,6199,5694,5170,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,84078,10197,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,CDKN1B,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,ANGPT1,PRKAR1A,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,PRKCE,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,KBTBD7,PSME3,AGO3
R-HSA-5654687	Downstream signaling of activated FGFR1	0.371382005583896	-0.990524081469118	310	89	0.039103690685413	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,5526,5566,805,5707,5687,5696,6464,5518,5296,28956,11221,8503,1027,253260,10768,7414,64223,7311,2931,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,4296,5690,5527,2932,5705,9861,4343,5700,5528,284,5573,23112,5689,5693,673,2335,7094,5245,5713,84335,23239,5715,1847,9491,5581,5781,3717,145957,5717,2065,7314,5686,1843,6709,6199,5694,5170,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,84078,10197,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,CDKN1B,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,ANGPT1,PRKAR1A,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,PRKCE,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,KBTBD7,PSME3,AGO3
R-HSA-5654708	Downstream signaling of activated FGFR3	0.371382005583896	-0.990524081469118	310	89	0.039103690685413	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,5526,5566,805,5707,5687,5696,6464,5518,5296,28956,11221,8503,1027,253260,10768,7414,64223,7311,2931,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,4296,5690,5527,2932,5705,9861,4343,5700,5528,284,5573,23112,5689,5693,673,2335,7094,5245,5713,84335,23239,5715,1847,9491,5581,5781,3717,145957,5717,2065,7314,5686,1843,6709,6199,5694,5170,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,84078,10197,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,CDKN1B,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,ANGPT1,PRKAR1A,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,PRKCE,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,KBTBD7,PSME3,AGO3
R-HSA-5654696	Downstream signaling of activated FGFR2	0.371382005583896	-0.990524081469118	310	89	0.039103690685413	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,5526,5566,805,5707,5687,5696,6464,5518,5296,28956,11221,8503,1027,253260,10768,7414,64223,7311,2931,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,4296,5690,5527,2932,5705,9861,4343,5700,5528,284,5573,23112,5689,5693,673,2335,7094,5245,5713,84335,23239,5715,1847,9491,5581,5781,3717,145957,5717,2065,7314,5686,1843,6709,6199,5694,5170,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,84078,10197,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,CDKN1B,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,ANGPT1,PRKAR1A,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,PRKCE,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,KBTBD7,PSME3,AGO3
R-HSA-432720	Lysosome Vesicle Biogenesis	0.373372837094061	-0.985177795314168	35	11	0.00483304042179262	2276	8202	27243,1213,3312,8907,1785,1777,9179,162,164,2647,4074	CHMP2A,CLTC,HSPA8,AP1M1,DNM2,DNASE2,AP4M1,AP1B1,AP1G1,BLOC1S1,M6PR
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression	0.376428150154187	-0.9770280861976	42	13	0.00571177504393673	2276	8202	2908,5187,79365,406,1408,6907,1628,8553,9575,10891,25819,9572,8864	NR3C1,PER1,BHLHE41,ARNTL,CRY2,TBL1X,DBP,BHLHE40,CLOCK,PPARGC1A,NOCT,NR1D1,PER2
R-HSA-5654736	Signaling by FGFR1	0.377470427174004	-0.974263051973597	314	90	0.0395430579964851	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,5526,5566,805,5707,5687,5696,6464,5518,5296,28956,11221,8503,1027,253260,10768,7414,64223,7311,2931,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,4296,5690,5527,2932,5705,9861,4343,5700,5528,284,5573,23112,5689,5693,673,2335,7094,5245,5713,84335,23239,5715,1847,9491,5581,5781,3717,145957,5717,2065,7314,10253,5686,1843,6709,6199,5694,5170,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,84078,10197,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,CDKN1B,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,ANGPT1,PRKAR1A,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,PRKCE,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,SPRY2,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,KBTBD7,PSME3,AGO3
R-HSA-2586552	Signaling by Leptin	0.3797833939248	-0.968154204769951	236	68	0.0298769771528998	2276	8202	161742,10142,200734,1848,4763,5894,5604,6777,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,25970,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,5781,3717,145957,5717,2065,7314,6774,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,STAT5B,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,SH2B1,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,STAT3,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-210993	Tie2 Signaling	0.381368610620332	-0.963988889621319	18	6	0.00263620386643234	2276	8202	3845,6464,284,5296,2886,5781	KRAS,SHC1,ANGPT1,PIK3R2,GRB7,PTPN11
R-HSA-163125	Post-translational modification: synthesis of GPI-anchored proteins	0.388882720782409	-0.944477469811871	25	8	0.00351493848857645	2276	8202	5279,51604,54872,128869,84720,5277,9487,5281	PIGC,PIGT,PIGG,PIGU,PIGO,PIGA,PIGL,PIGF
R-HSA-982772	Growth hormone receptor signaling	0.388882720782409	-0.944477469811871	25	8	0.00351493848857645	2276	8202	6868,5770,8651,25970,6772,6777,3717,6774	ADAM17,PTPN1,SOCS1,SH2B1,STAT1,STAT5B,JAK2,STAT3
R-HSA-210991	Basigin interactions	0.388882720782409	-0.944477469811871	25	8	0.00351493848857645	2276	8202	6520,23657,3688,682,6566,483,857,5478	SLC3A2,SLC7A11,ITGB1,BSG,SLC16A1,ATP1B3,CAV1,PPIA
R-HSA-73928	Depyrimidination	0.390876096211517	-0.939364658701464	8	3	0.00131810193321617	2276	8202	79661,6996,4913	NEIL1,TDG,NTHL1
R-HSA-110329	Cleavage of the damaged pyrimidine	0.390876096211517	-0.939364658701464	8	3	0.00131810193321617	2276	8202	79661,6996,4913	NEIL1,TDG,NTHL1
R-HSA-389887	Beta-oxidation of pristanoyl-CoA	0.390876096211517	-0.939364658701464	8	3	0.00131810193321617	2276	8202	3295,8310,10005	HSD17B4,ACOX3,ACOT8
R-HSA-2046105	Linoleic acid (LA) metabolism	0.390876096211517	-0.939364658701464	8	3	0.00131810193321617	2276	8202	3992,9415,60481	FADS1,FADS2,ELOVL5
R-HSA-446388	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	0.390876096211517	-0.939364658701464	8	3	0.00131810193321617	2276	8202	29780,87,6251	PARVB,ACTN1,RSU1
R-HSA-163765	ChREBP activates metabolic gene expression	0.390876096211517	-0.939364658701464	8	3	0.00131810193321617	2276	8202	6945,47,10554	MLX,ACLY,AGPAT1
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected pyrimidine	0.390876096211517	-0.939364658701464	8	3	0.00131810193321617	2276	8202	79661,6996,4913	NEIL1,TDG,NTHL1
R-HSA-6788656	Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism	0.394558820338683	-0.929987048825402	39	12	0.00527240773286467	2276	8202	8659,2954,5625,883,8942,56267,501,4967,2639,1743,1738,144193	ALDH4A1,GSTZ1,PRODH,CCBL1,KYNU,CCBL2,ALDH7A1,OGDH,GCDH,DLST,DLD,AMDHD1
R-HSA-5654738	Signaling by FGFR2	0.405000716807502	-0.903866441982098	316	90	0.0395430579964851	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,5526,5566,805,5707,5687,5696,6464,5518,5296,28956,11221,8503,1027,253260,10768,7414,64223,7311,2931,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,4296,5690,5527,2932,5705,9861,4343,5700,5528,284,5573,23112,5689,5693,673,2335,7094,5245,5713,84335,23239,5715,1847,9491,5581,5781,3717,145957,5717,2065,7314,10253,5686,1843,6709,6199,5694,5170,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,84078,10197,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,CDKN1B,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,ANGPT1,PRKAR1A,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,PRKCE,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,SPRY2,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,KBTBD7,PSME3,AGO3
R-HSA-5099900	WNT5A-dependent internalization of FZD4	0.406765544650841	-0.899518316893276	15	5	0.00219683655536028	2276	8202	163,1175,160,1856,1213	AP2B1,AP2S1,AP2A1,DVL2,CLTC
R-HSA-392170	ADP signalling through P2Y purinoceptor 12	0.412070483329686	-0.88656086822152	22	7	0.00307557117750439	2276	8202	51764,2771,2773,2783,59345,2787,2788	GNG13,GNAI2,GNAI3,GNB2,GNB4,GNG5,GNG7
R-HSA-2892247	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	0.412070483329686	-0.88656086822152	22	7	0.00307557117750439	2276	8202	5432,5440,2649,6774,5431,5430,5434	POLR2C,POLR2K,NR6A1,STAT3,POLR2B,POLR2A,POLR2E
R-HSA-917937	Iron uptake and transport	0.413776644852301	-0.882428955929791	43	13	0.00571177504393673	2276	8202	2512,51382,523,535,23545,4891,51606,3163,528,529,28982,9114,7037	FTL,ATP6V1D,ATP6V1A,ATP6V0A1,ATP6V0A2,SLC11A2,ATP6V1H,HMOX2,ATP6V1C1,ATP6V1E1,FLVCR1,ATP6V0D1,TFRC
R-HSA-1912408	Pre-NOTCH Transcription and Translation	0.413930609427476	-0.882056929283522	29	9	0.00395430579964851	2276	8202	3725,595,23112,7157,1871,3516,9794,4343,192669	JUN,CCND1,TNRC6B,TP53,E2F3,RBPJ,MAML1,MOV10,AGO3
R-HSA-917977	Transferrin endocytosis and recycling	0.413930609427476	-0.882056929283522	29	9	0.00395430579964851	2276	8202	51382,523,23545,535,528,51606,529,9114,7037	ATP6V1D,ATP6V1A,ATP6V0A2,ATP6V0A1,ATP6V1C1,ATP6V1H,ATP6V1E1,ATP6V0D1,TFRC
R-HSA-5601884	PIWI-interacting RNA (piRNA) biogenesis	0.413930609427476	-0.882056929283522	29	9	0.00395430579964851	2276	8202	5432,5440,113802,201164,5434,11022,3320,5430,5431	POLR2C,POLR2K,HENMT1,PLD6,POLR2E,TDRKH,HSP90AA1,POLR2A,POLR2B
R-HSA-442742	CREB phosphorylation through the activation of Ras	0.413930609427476	-0.882056929283522	29	9	0.00395430579964851	2276	8202	5170,805,817,10142,673,6196,6237,5894,1742	PDPK1,CALM2,CAMK2D,AKAP9,BRAF,RPS6KA2,RRAS,RAF1,DLG4
R-HSA-163841	Gamma carboxylation, hypusine formation and arylsulfatase activation	0.414254429109762	-0.881274930856311	36	11	0.00483304042179262	2276	8202	83475,1984,2677,1938,1801,1725,1802,56648,25870,89978,285381	DOHH,EIF5A,GGCX,EEF2,DPH1,DHPS,DPH2,EIF5A2,SUMF2,DPH6,DPH3
R-HSA-190236	Signaling by FGFR	0.418902730968773	-0.870116531669228	317	90	0.0395430579964851	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,5526,5566,805,5707,5687,5696,6464,5518,5296,28956,11221,8503,1027,253260,10768,7414,64223,7311,2931,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,4296,5690,5527,2932,5705,9861,4343,5700,5528,284,5573,23112,5689,5693,673,2335,7094,5245,5713,84335,23239,5715,1847,9491,5581,5781,3717,145957,5717,2065,7314,10253,5686,1843,6709,6199,5694,5170,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,84078,10197,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,CDKN1B,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,ANGPT1,PRKAR1A,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,PRKCE,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,SPRY2,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,KBTBD7,PSME3,AGO3
R-HSA-77310	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	3033,3032	HADH,HADHB
R-HSA-73943	Reversal of alkylation damage by DNA dioxygenases	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	10973,121642	ASCC3,ALKBH2
R-HSA-5652084	Fructose metabolism	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	231,6652	AKR1B1,SORD
R-HSA-2161541	Abacavir metabolism	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	2987,5105	GUK1,PCK1
R-HSA-77346	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	3033,3032	HADH,HADHB
R-HSA-77348	Beta oxidation of octanoyl-CoA to hexanoyl-CoA	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	3033,3032	HADH,HADHB
R-HSA-197264	Nicotinamide salvaging	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	5743,93100	PTGS2,NAPRT
R-HSA-114516	Disinhibition of SNARE formation	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	6814,6810	STXBP3,STX4
R-HSA-1306955	GRB7 events in ERBB2 signaling	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	2065,2886	ERBB3,GRB7
R-HSA-77350	Beta oxidation of hexanoyl-CoA to butanoyl-CoA	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	3033,3032	HADH,HADHB
R-HSA-180689	APOBEC3G mediated resistance to HIV-1 infection	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	3159,5478	HMGA1,PPIA
R-HSA-196843	Vitamin B2 (riboflavin) metabolism	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	80308,55312	FLAD1,RFK
R-HSA-163680	AMPK inhibits chREBP transcriptional activation activity	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	51422,5565	PRKAG2,PRKAB2
R-HSA-68911	G2 Phase	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	890,1871	CCNA2,E2F3
R-HSA-5368598	Negative regulation of TCF-dependent signaling by DVL-interacting proteins	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	80319,1856	CXXC4,DVL2
R-HSA-426048	Arachidonate production from DAG	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	221955,26090	DAGLB,ABHD12
R-HSA-5661270	Catabolism of glucuronate to xylulose-5-phosphate	0.425044990368929	-0.855560255968865	5	2	0.000878734622144112	2276	8202	6652,10327	SORD,AKR1A1
R-HSA-2424491	DAP12 signaling	0.43071643910631	-0.84230531930519	325	92	0.0404217926186292	2276	8202	10142,200734,161742,1848,4763,2475,5894,5604,1147,5526,5566,805,5707,5696,5687,6464,5518,5296,28956,1027,11221,8503,253260,10768,7414,64223,7311,2931,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,4296,2932,5527,5690,5705,9861,4343,5528,5700,284,5573,5689,23112,673,5693,2335,7094,3133,5245,5713,567,84335,23239,5715,9491,1847,5581,5781,3717,145957,5717,2065,7314,5686,5694,6709,1843,6199,5170,10451,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,84078,10197,192669	AKAP9,SPRED2,SPRED1,DUSP6,NF1,MTOR,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,PIK3R2,LAMTOR2,CDKN1B,DUSP10,PIK3R3,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,GSK3B,PPP2R5C,PSMB2,PSMC5,PSMD6,MOV10,PPP2R5D,PSMC1,ANGPT1,PRKAR1A,PSMB1,TNRC6B,BRAF,PSMB5,FN1,TLN1,HLA-E,PHB,PSMD7,B2M,AKT1S1,PHLPP1,PSMD9,PSMF1,DUSP5,PRKCE,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,PSMB6,SPTAN1,DUSP1,RPS6KB2,PDPK1,VAV3,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,KBTBD7,PSME3,AGO3
R-HSA-73847	Purine metabolism	0.435778996601732	-0.83062005267266	33	10	0.00439367311072056	2276	8202	159,51292,2618,5198,5471,10606,3614,30833,3615,1716	ADSS,GMPR2,GART,PFAS,PPAT,PAICS,IMPDH1,NT5C,IMPDH2,DGUOK
R-HSA-156581	Methylation	0.437307602925221	-0.827118434651693	12	4	0.00175746924428822	2276	8202	27430,4837,4548,4552	MAT2B,NNMT,MTR,MTRR
R-HSA-199220	Vitamin B5 (pantothenate) metabolism	0.437307602925221	-0.827118434651693	12	4	0.00175746924428822	2276	8202	80025,8884,60496,8034	PANK2,SLC5A6,AASDHPPT,SLC25A16
R-HSA-202670	ERKs are inactivated	0.437307602925221	-0.827118434651693	12	4	0.00175746924428822	2276	8202	1848,5598,5518,5528	DUSP6,MAPK7,PPP2R1A,PPP2R5D
R-HSA-844456	The NLRP3 inflammasome	0.437307602925221	-0.827118434651693	12	4	0.00175746924428822	2276	8202	10910,3326,10628,24145	SUGT1,HSP90AB1,TXNIP,PANX1
R-HSA-1474151	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	0.437307602925221	-0.827118434651693	12	4	0.00175746924428822	2276	8202	805,5805,3320,2644	CALM2,PTS,HSP90AA1,GCHFR
R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	0.437602123161622	-0.826445176054276	26	8	0.00351493848857645	2276	8202	9156,5889,675,83990,7516,7156,7517,641	EXO1,RAD51C,BRCA2,BRIP1,XRCC2,TOP3A,XRCC3,BLM
R-HSA-77387	Insulin receptor recycling	0.437602123161622	-0.826445176054276	26	8	0.00351493848857645	2276	8202	51382,523,23545,535,528,51606,529,9114	ATP6V1D,ATP6V1A,ATP6V0A2,ATP6V0A1,ATP6V1C1,ATP6V1H,ATP6V1E1,ATP6V0D1
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	0.438650602013476	-0.824052077985397	254	72	0.031634446397188	2276	8202	10142,200734,161742,1848,4763,5894,5604,6777,5526,5566,1399,805,5707,5696,5687,6464,5518,5296,28956,11221,8503,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5527,5690,5705,9861,5528,5700,284,5689,673,5693,3636,2335,7094,5245,5713,5715,9491,1847,5781,3717,145957,5717,2065,7314,5686,1843,6709,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,7534,10197	AKAP9,SPRED2,SPRED1,DUSP6,NF1,RAF1,MAP2K1,STAT5B,PPP2R5B,PRKACA,CRKL,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PPP2R5C,PSMB2,PSMC5,PSMD6,PPP2R5D,PSMC1,ANGPT1,PSMB1,BRAF,PSMB5,INPPL1,FN1,TLN1,PHB,PSMD7,PSMD9,PSMF1,DUSP5,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,YWHAZ,PSME3
R-HSA-5654700	FRS-mediated FGFR2 signaling	0.43918466453467	-0.822835306211837	229	65	0.0285588752196837	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,5781,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,PTPN11,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-5654693	FRS-mediated FGFR1 signaling	0.43918466453467	-0.822835306211837	229	65	0.0285588752196837	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,5781,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,PTPN11,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-5654712	FRS-mediated FGFR4 signaling	0.43918466453467	-0.822835306211837	229	65	0.0285588752196837	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,5781,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,PTPN11,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-5654706	FRS-mediated FGFR3 signaling	0.43918466453467	-0.822835306211837	229	65	0.0285588752196837	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,5781,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,PTPN11,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-1483255	PI Metabolism	0.447556785123869	-0.803951855186056	51	15	0.00659050966608084	2276	8202	51763,8396,3636,5289,5298,9110,5296,30849,8503,22908,8394,200576,8867,55697,55361	INPP5K,PIP4K2B,INPPL1,PIK3C3,PI4KB,MTMR4,PIK3R2,PIK3R4,PIK3R3,SACM1L,PIP5K1A,PIKFYVE,SYNJ1,VAC14,PI4K2A
R-HSA-5362517	Signaling by Retinoic Acid	0.451213590246873	-0.795814459023894	44	13	0.00571177504393673	2276	8202	5915,5160,5467,5164,5914,5163,5166,57665,157506,112724,9249,1738,6257	RARB,PDHA1,PPARD,PDK2,RARA,PDK1,PDK4,RDH14,RDH10,RDH13,DHRS3,DLD,RXRB
R-HSA-2871796	FCERI mediated MAPK activation	0.45696341184806	-0.783151952894654	248	70	0.0307557117750439	2276	8202	10142,200734,161742,1848,4763,5894,5604,5526,805,5707,5696,5687,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5527,5690,5705,9861,5528,5700,284,5689,673,5693,2335,7094,5245,5713,5715,9491,1847,3725,5601,3717,145957,5717,2065,7314,5686,1843,6709,5694,5058,10451,5609,5692,5702,5682,3845,5710,2353,4140,7316,5691,369,84078,10197	AKAP9,SPRED2,SPRED1,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PPP2R5C,PSMB2,PSMC5,PSMD6,PPP2R5D,PSMC1,ANGPT1,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,PSMF1,DUSP5,JUN,MAPK9,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,PSMB6,PAK1,VAV3,MAP2K7,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,FOS,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-203927	MicroRNA (miRNA) biogenesis	0.464267739938244	-0.767293867442238	23	7	0.00307557117750439	2276	8202	5432,5440,5431,192669,5430,5434,6895	POLR2C,POLR2K,POLR2B,AGO3,POLR2A,POLR2E,TARBP2
R-HSA-451927	Interleukin-2 signaling	0.466322371189185	-0.762878100360737	245	69	0.0303163444639719	2276	8202	10142,200734,161742,1848,4763,5894,5604,6777,5526,805,5707,5696,5687,6464,5518,5296,28956,11221,8503,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5527,5690,2185,5705,9861,5528,5700,284,5689,673,5693,3636,2335,7094,5245,5713,5715,9491,1847,3717,145957,5717,2065,7314,5686,1843,6709,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	AKAP9,SPRED2,SPRED1,DUSP6,NF1,RAF1,MAP2K1,STAT5B,PPP2R5B,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PPP2R5C,PSMB2,PTK2B,PSMC5,PSMD6,PPP2R5D,PSMC1,ANGPT1,PSMB1,BRAF,PSMB5,INPPL1,FN1,TLN1,PHB,PSMD7,PSMD9,PSMF1,DUSP5,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-912526	Interleukin receptor SHC signaling	0.469195488822179	-0.756735776865025	238	67	0.0294376098418278	2276	8202	10142,200734,161742,1848,4763,5894,5604,5526,805,5707,5696,5687,6464,5518,5296,28956,11221,8503,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5527,5690,5705,9861,5528,5700,284,5689,673,5693,3636,2335,7094,5245,5713,5715,9491,1847,145957,5717,3717,2065,7314,5686,1843,6709,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	AKAP9,SPRED2,SPRED1,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PPP2R5C,PSMB2,PSMC5,PSMD6,PPP2R5D,PSMC1,ANGPT1,PSMB1,BRAF,PSMB5,INPPL1,FN1,TLN1,PHB,PSMD7,PSMD9,PSMF1,DUSP5,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-1170546	Prolactin receptor signaling	0.469726494331028	-0.7556046806185	16	5	0.00219683655536028	2276	8202	3717,6777,8945,25970,5781	JAK2,STAT5B,BTRC,SH2B1,PTPN11
R-HSA-392517	Rap1 signalling	0.469726494331028	-0.7556046806185	16	5	0.00219683655536028	2276	8202	7534,10411,5566,5894,11069	YWHAZ,RAPGEF3,PRKACA,RAF1,RAPGEF4
R-HSA-446353	Cell-extracellular matrix interactions	0.469726494331028	-0.7556046806185	16	5	0.00219683655536028	2276	8202	29780,87,7408,6251,3688	PARVB,ACTN1,VASP,RSU1,ITGB1
R-HSA-2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	0.469726494331028	-0.7556046806185	16	5	0.00219683655536028	2276	8202	50848,7311,7314,6233,7316	F11R,UBA52,UBB,RPS27A,UBC
R-HSA-110357	Displacement of DNA glycosylase by APEX1	0.476029373424414	-0.742275717779812	9	3	0.00131810193321617	2276	8202	6996,4913,4595	TDG,NTHL1,MUTYH
R-HSA-428890	Role of Abl in Robo-Slit signaling	0.476029373424414	-0.742275717779812	9	3	0.00131810193321617	2276	8202	27,23122,10487	ABL2,CLASP2,CAP1
R-HSA-426486	Small interfering RNA (siRNA) biogenesis	0.476029373424414	-0.742275717779812	9	3	0.00131810193321617	2276	8202	192669,7247,6895	AGO3,TSN,TARBP2
R-HSA-73614	Pyrimidine salvage reactions	0.476029373424414	-0.742275717779812	9	3	0.00131810193321617	2276	8202	1890,7083,7378	TYMP,TK1,UPP1
R-HSA-727802	Transport of nucleotide sugars	0.476029373424414	-0.742275717779812	9	3	0.00131810193321617	2276	8202	55343,10559,84912	SLC35C1,SLC35A1,SLC35B4
R-HSA-198693	AKT phosphorylates targets in the nucleus	0.476029373424414	-0.742275717779812	9	3	0.00131810193321617	2276	8202	3164,208,6199	NR4A1,AKT2,RPS6KB2
R-HSA-201688	WNT mediated activation of DVL	0.476029373424414	-0.742275717779812	9	3	0.00131810193321617	2276	8202	1460,1454,1856	CSNK2B,CSNK1E,DVL2
R-HSA-3215018	Processing and activation of SUMO	0.476029373424414	-0.742275717779812	9	3	0.00131810193321617	2276	8202	7329,59343,7341	UBE2I,SENP2,SUMO1
R-HSA-168330	Viral RNP Complexes in the Host Cell Nucleus	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	3304	HSPA1B
R-HSA-68881	Mitotic Metaphase/Anaphase Transition	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	26271	FBXO5
R-HSA-69560	Transcriptional activation of p53 responsive genes	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	7157	TP53
R-HSA-192905	vRNP Assembly	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	3320	HSP90AA1
R-HSA-379397	Enzymatic degradation of dopamine by COMT	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	4128	MAOA
R-HSA-3828062	Glycogen storage disease type 0 (muscle GYS1)	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	2997	GYS1
R-HSA-75102	C6 deamination of adenosine	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	103	ADAR
R-HSA-5545619	XAV939 inhibits tankyrase, stabilizing AXIN	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	8658	TNKS
R-HSA-1614603	Cysteine formation from homocysteine	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	1491	CTH
R-HSA-380612	Metabolism of serotonin	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	4128	MAOA
R-HSA-69895	Transcriptional  activation of  cell cycle inhibitor p21	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	7157	TP53
R-HSA-75064	mRNA Editing: A to I Conversion	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	103	ADAR
R-HSA-156582	Acetylation	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	9	NAT1
R-HSA-165160	PDE3B signalling	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	208	AKT2
R-HSA-203754	NOSIP mediated eNOS trafficking	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	51070	NOSIP
R-HSA-380615	Serotonin clearance from the synaptic cleft	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	4128	MAOA
R-HSA-3359478	Defective MUT causes methylmalonic aciduria mut type	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	4594	MUT
R-HSA-3359475	Defective MMAA causes methylmalonic aciduria type cblA	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	4594	MUT
R-HSA-114294	Activation, translocation and oligomerization of BAX	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	581	BAX
R-HSA-379398	Enzymatic degradation of Dopamine by monoamine oxidase	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	4128	MAOA
R-HSA-3814836	Glycogen storage disease type XV (GYG1)	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	2997	GYS1
R-HSA-141333	Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	4128	MAOA
R-HSA-73930	Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	5423	POLB
R-HSA-3359485	Defective CD320 causes methylmalonic aciduria	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	51293	CD320
R-HSA-77042	Formation of editosomes by ADAR proteins	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	103	ADAR
R-HSA-1483226	Synthesis of PI	0.478008507344473	-0.738126748857275	2	1	0.000439367311072056	2276	8202	1040	CDS1
R-HSA-1963640	GRB2 events in ERBB2 signaling	0.48195984898302	-0.72989446926635	228	64	0.0281195079086116	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-1250347	SHC1 events in ERBB4 signaling	0.48195984898302	-0.72989446926635	228	64	0.0281195079086116	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-180336	SHC1 events in EGFR signaling	0.48195984898302	-0.72989446926635	228	64	0.0281195079086116	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-5673001	RAF/MAP kinase cascade	0.48195984898302	-0.72989446926635	228	64	0.0281195079086116	2276	8202	10142,200734,161742,1848,4763,5894,5604,5526,805,5707,5696,5687,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5527,5690,5705,9861,5528,5700,284,5689,673,5693,2335,7094,5245,5713,5715,9491,1847,145957,5717,3717,2065,7314,5686,1843,6709,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	AKAP9,SPRED2,SPRED1,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PPP2R5C,PSMB2,PSMC5,PSMD6,PPP2R5D,PSMC1,ANGPT1,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,PSMF1,DUSP5,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,DUSP1,SPTAN1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-179812	GRB2 events in EGFR signaling	0.48195984898302	-0.72989446926635	228	64	0.0281195079086116	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-112412	SOS-mediated signalling	0.48195984898302	-0.72989446926635	228	64	0.0281195079086116	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-1250196	SHC1 events in ERBB2 signaling	0.48195984898302	-0.72989446926635	228	64	0.0281195079086116	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-400685	Sema4D in semaphorin signaling	0.485777076555667	-0.722005450526857	27	8	0.00351493848857645	2276	8202	6237,998,4637,4627,23365,4233,4628,9475	RRAS,CDC42,MYL6,MYH9,ARHGEF12,MET,MYH10,ROCK2
R-HSA-187706	Signalling to p38 via RIT and RIN	0.488630537850015	-0.716148621395222	232	65	0.0285588752196837	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,6016,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,RIT1,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-1483191	Synthesis of PC	0.494772087566302	-0.703658051602486	20	6	0.00263620386643234	2276	8202	162466,64900,10400,23446,5130,1119	PHOSPHO1,LPIN3,PEMT,SLC44A1,PCYT1A,CHKA
R-HSA-111465	Apoptotic cleavage of cellular proteins	0.495663972189799	-0.701857057271178	38	11	0.00483304042179262	2276	8202	840,1499,4001,324,7082,22985,5339,1832,329,4000,6709	CASP7,CTNNB1,LMNB1,APC,TJP1,ACIN1,PLEC,DSP,BIRC2,LMNA,SPTAN1
R-HSA-170968	Frs2-mediated activation	0.505079169091	-0.683040091516757	233	65	0.0285588752196837	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,1399,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CRKL,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-3270619	IRF3-mediated induction of type I IFN	0.507349311801153	-0.67855553471573	13	4	0.00175746924428822	2276	8202	51428,2547,23220,7520	DDX41,XRCC6,DTX4,XRCC5
R-HSA-879415	Advanced glycosylation endproduct receptor signaling	0.507349311801153	-0.67855553471573	13	4	0.00175746924428822	2276	8202	3146,1650,5589,829	HMGB1,DDOST,PRKCSH,CAPZA1
R-HSA-174403	Glutathione synthesis and recycling	0.507349311801153	-0.67855553471573	13	4	0.00175746924428822	2276	8202	79017,55748,2729,2937	GGCT,CNDP2,GCLC,GSS
R-HSA-3134963	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	0.507349311801153	-0.67855553471573	13	4	0.00175746924428822	2276	8202	3146,4791,5970,170506	HMGB1,NFKB2,RELA,DHX36
R-HSA-5626467	RHO GTPases activate IQGAPs	0.507349311801153	-0.67855553471573	13	4	0.00175746924428822	2276	8202	805,1499,998,1495	CALM2,CTNNB1,CDC42,CTNNA1
R-HSA-177504	Retrograde neurotrophin signalling	0.507349311801153	-0.67855553471573	13	4	0.00175746924428822	2276	8202	163,1175,160,1785	AP2B1,AP2S1,AP2A1,DNM2
R-HSA-186797	Signaling by PDGF	0.508190353333267	-0.676899190304438	345	96	0.0421792618629174	2276	8202	161742,10142,200734,1848,2475,4763,5894,5604,1147,6777,5526,5566,1399,805,5707,5687,5696,6464,5518,5296,28956,11221,8503,1027,253260,10768,7414,64223,7311,2931,4690,208,842,5695,1742,572,5529,817,5719,6233,5714,6778,5709,6772,4296,5690,5527,2932,5705,9861,4343,5700,5528,284,5573,23112,5689,5693,673,2335,7094,5245,5713,84335,23239,5715,1847,9491,5581,5781,3717,145957,5717,2065,7314,6774,5686,1843,6709,6199,5694,5170,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,2886,84078,10197,192669	SPRED1,AKAP9,SPRED2,DUSP6,MTOR,NF1,RAF1,MAP2K1,CHUK,STAT5B,PPP2R5B,PRKACA,CRKL,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,CDKN1B,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,NCK1,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,STAT6,PSMD3,STAT1,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,PPP2R5D,ANGPT1,PRKAR1A,TNRC6B,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,AKT1S1,PHLPP1,PSMD9,DUSP5,PSMF1,PRKCE,PTPN11,JAK2,NRG4,PSMD11,ERBB3,UBB,STAT3,PSMA5,DUSP1,SPTAN1,RPS6KB2,PSMB6,PDPK1,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,GRB7,KBTBD7,PSME3,AGO3
R-HSA-73848	Pyrimidine metabolism	0.515296364823831	-0.663013078157937	24	7	0.00307557117750439	2276	8202	1723,7372,30833,1890,7083,7378,1854	DHODH,UMPS,NT5C,TYMP,TK1,UPP1,DUT
R-HSA-68952	DNA replication initiation	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	23649,5422	POLA2,POLA1
R-HSA-5660668	CLEC7A/inflammasome pathway	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	5970,10892	RELA,MALT1
R-HSA-1482798	Acyl chain remodeling of CL	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	253558,3032	LCLAT1,HADHB
R-HSA-1566977	Fibronectin matrix formation	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	2335,3688	FN1,ITGB1
R-HSA-947581	Molybdenum cofactor biosynthesis	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	27304,9054	MOCS3,NFS1
R-HSA-5626978	TNFR1-mediated ceramide production	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	55512,10399	SMPD3,GNB2L1
R-HSA-5579029	Metabolic disorders of biological oxidation enzymes	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	112812,2232	FDX1L,FDXR
R-HSA-3065678	SUMO is transferred from E1 to E2 (UBE2I, UBC9)	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	7329,7341	UBE2I,SUMO1
R-HSA-3065679	SUMO is proteolytically processed	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	59343,7341	SENP2,SUMO1
R-HSA-77288	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	1632,3032	ECI1,HADHB
R-HSA-174430	Telomere C-strand synthesis initiation	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	23649,5422	POLA2,POLA1
R-HSA-2142770	Synthesis of 15-eicosatetraenoic acid derivatives	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	5743,2879	PTGS2,GPX4
R-HSA-73942	DNA Damage Reversal	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	10973,121642	ASCC3,ALKBH2
R-HSA-444257	RSK activation	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	5170,6196	PDPK1,RPS6KA2
R-HSA-189483	Heme degradation	0.530000751549306	-0.634876854419415	6	2	0.000878734622144112	2276	8202	3163,645	HMOX2,BLVRB
R-HSA-622312	Inflammasomes	0.530385182728804	-0.634151776532369	17	5	0.00219683655536028	2276	8202	10910,598,3326,10628,24145	SUGT1,BCL2L1,HSP90AB1,TXNIP,PANX1
R-HSA-435354	Zinc transporters	0.530385182728804	-0.634151776532369	17	5	0.00219683655536028	2276	8202	7779,64924,64116,27173,55676	SLC30A1,SLC30A5,SLC39A8,SLC39A1,SLC30A6
R-HSA-2142845	Hyaluronan metabolism	0.530385182728804	-0.634151776532369	17	5	0.00219683655536028	2276	8202	3161,6548,3373,8372,2990	HMMR,SLC9A1,HYAL1,HYAL3,GUSB
R-HSA-189445	Metabolism of porphyrins	0.530385182728804	-0.634151776532369	17	5	0.00219683655536028	2276	8202	3145,210,3163,5498,645	HMBS,ALAD,HMOX2,PPOX,BLVRB
R-HSA-70221	Glycogen breakdown (glycogenolysis)	0.530385182728804	-0.634151776532369	17	5	0.00219683655536028	2276	8202	805,5256,5837,5261,5257	CALM2,PHKA2,PYGM,PHKG2,PHKB
R-HSA-909733	Interferon alpha/beta signaling	0.532093927255585	-0.63093525023279	68	19	0.00834797891036907	2276	8202	1958,3133,3134,11274,51447,7297,6773,3105,3669,5770,5696,8651,6772,5781,10379,3660,103,3107,2537	EGR1,HLA-E,HLA-F,USP18,IP6K2,TYK2,STAT2,HLA-A,ISG20,PTPN1,PSMB8,SOCS1,STAT1,PTPN11,IRF9,IRF2,ADAR,HLA-C,IFI6
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion	0.532770196701029	-0.62966509844319	28	8	0.00351493848857645	2276	8202	51764,784,2771,783,2783,59345,2787,2788	GNG13,CACNB3,GNAI2,CACNB2,GNB2,GNB4,GNG5,GNG7
R-HSA-169893	Prolonged ERK activation events	0.537760923994945	-0.620341196777598	235	65	0.0285588752196837	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,1399,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CRKL,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-187687	Signalling to ERKs	0.53996058681611	-0.6162591294651	246	68	0.0298769771528998	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,1399,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5900,5715,1847,9491,3717,145957,5717,2065,7314,5686,6709,1843,5694,5692,7867,5702,5682,3845,6016,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CRKL,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,RALGDS,PSMD9,DUSP5,PSMF1,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,MAPKAPK3,PSMC3,PSMA1,KRAS,RIT1,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-167044	Signalling to RAS	0.543868696029368	-0.609047428853114	239	66	0.0289982425307557	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5900,5715,1847,9491,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,7867,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,RALGDS,PSMD9,DUSP5,PSMF1,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,MAPKAPK3,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-170984	ARMS-mediated activation	0.54789617570272	-0.601669470380506	232	64	0.0281195079086116	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,145957,5717,3717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-389356	CD28 co-stimulation	0.54804666388931	-0.601394842576758	32	9	0.00395430579964851	2276	8202	5058,5170,998,2475,208,5296,8503,253260,64223	PAK1,PDPK1,CDC42,MTOR,AKT2,PIK3R2,PIK3R3,RICTOR,MLST8
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	0.548866177066598	-0.599900624806363	21	6	0.00263620386643234	2276	8202	1147,3146,8517,4791,5970,3551	CHUK,HMGB1,IKBKG,NFKB2,RELA,IKBKB
R-HSA-4641263	Regulation of FZD by ubiquitination	0.548866177066598	-0.599900624806363	21	6	0.00263620386643234	2276	8202	4040,7311,7314,6233,7316,9101	LRP6,UBA52,UBB,RPS27A,UBC,USP8
R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	0.555138135432554	-0.588538303533077	10	3	0.00131810193321617	2276	8202	10038,7515,2237	PARP2,XRCC1,FEN1
R-HSA-2470946	Cohesin Loading onto Chromatin	0.555138135432554	-0.588538303533077	10	3	0.00131810193321617	2276	8202	25836,10274,8243	NIPBL,STAG1,SMC1A
R-HSA-425410	Metal ion SLC transporters	0.56445722640842	-0.571890670790461	25	7	0.00307557117750439	2276	8202	4891,1317,7779,64924,64116,27173,55676	SLC11A2,SLC31A1,SLC30A1,SLC30A5,SLC39A8,SLC39A1,SLC30A6
R-HSA-5675482	Regulation of necroptotic cell death	0.573140962648456	-0.556623584409943	14	4	0.00175746924428822	2276	8202	330,7186,329,8772	BIRC3,TRAF2,BIRC2,FADD
R-HSA-5218921	VEGFR2 mediated cell proliferation	0.575744437674192	-0.552091401336795	241	66	0.0289982425307557	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,10768,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,1847,9491,145957,5717,3717,2065,7314,5686,6709,1843,5694,5170,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,AHCYL1,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,DUSP5,PSMF1,NRG4,PSMD11,JAK2,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PDPK1,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-5654732	Negative regulation of FGFR3 signaling	0.578042420430542	-0.54810802125446	29	8	0.00351493848857645	2276	8202	7311,673,7314,5518,6233,10253,7316,5781	UBA52,BRAF,UBB,PPP2R1A,RPS27A,SPRY2,UBC,PTPN11
R-HSA-2172127	DAP12 interactions	0.58726961202519	-0.532271259619	340	93	0.0408611599297012	2276	8202	10142,200734,161742,1848,4763,2475,5894,5604,1147,5526,5566,805,5707,5696,5687,6464,5518,5296,28956,1027,11221,8503,253260,10768,7414,64223,7311,2931,208,842,5695,1742,572,5529,817,5719,6233,5714,5709,4296,2932,5527,5690,5705,9861,4343,5528,5700,284,5573,5689,23112,673,5693,2335,7094,3133,5245,5713,567,84335,23239,5715,9491,1847,5581,5781,3717,145957,5717,2065,3107,7314,5686,5694,6709,1843,6199,5170,10451,5692,3164,5702,5682,3845,5710,4140,5691,7316,369,84078,10197,192669	AKAP9,SPRED2,SPRED1,DUSP6,NF1,MTOR,RAF1,MAP2K1,CHUK,PPP2R5B,PRKACA,CALM2,PSMD1,PSMB8,PSMA6,SHC1,PPP2R1A,PIK3R2,LAMTOR2,CDKN1B,DUSP10,PIK3R3,RICTOR,AHCYL1,VCL,MLST8,UBA52,GSK3A,AKT2,CASP9,PSMB7,DLG4,BAD,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,GSK3B,PPP2R5C,PSMB2,PSMC5,PSMD6,MOV10,PPP2R5D,PSMC1,ANGPT1,PRKAR1A,PSMB1,TNRC6B,BRAF,PSMB5,FN1,TLN1,HLA-E,PHB,PSMD7,B2M,AKT1S1,PHLPP1,PSMD9,PSMF1,DUSP5,PRKCE,PTPN11,JAK2,NRG4,PSMD11,ERBB3,HLA-C,UBB,PSMA5,PSMB6,SPTAN1,DUSP1,RPS6KB2,PDPK1,VAV3,PSMB4,NR4A1,PSMC3,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,ARAF,KBTBD7,PSME3,AGO3
R-HSA-1839117	Signaling by FGFR1 fusion mutants	0.587699248913208	-0.531539943374884	18	5	0.00219683655536028	2276	8202	6777,8805,6774,11052,6772	STAT5B,TRIM24,STAT3,CPSF6,STAT1
R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	0.587699248913208	-0.531539943374884	18	5	0.00219683655536028	2276	8202	7311,7314,6233,7316,5781	UBA52,UBB,RPS27A,UBC,PTPN11
R-HSA-1912420	Pre-NOTCH Processing in Golgi	0.587699248913208	-0.531539943374884	18	5	0.00219683655536028	2276	8202	6484,5870,488,10959,6400	ST3GAL4,RAB6A,ATP2A2,TMED2,SEL1L
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.590147039121586	-0.527383554282086	33	9	0.00395430579964851	2276	8202	9156,5889,675,83990,7516,7156,7517,641,348654	EXO1,RAD51C,BRCA2,BRIP1,XRCC2,TOP3A,XRCC3,BLM,GEN1
R-HSA-373753	Nephrin interactions	0.600164562199611	-0.510551391038538	22	6	0.00263620386643234	2276	8202	87,23607,4690,8976,5296,6709	ACTN1,CD2AP,NCK1,WASL,PIK3R2,SPTAN1
R-HSA-438064	Post NMDA receptor activation events	0.601108844406128	-0.508979255343506	37	10	0.00439367311072056	2276	8202	5170,805,817,10142,673,6196,6237,5894,1742,5566	PDPK1,CALM2,CAMK2D,AKAP9,BRAF,RPS6KA2,RRAS,RAF1,DLG4,PRKACA
R-HSA-75153	Apoptotic execution  phase	0.605325903531544	-0.501988282465967	52	14	0.00615114235500879	2276	8202	3146,840,1499,4001,3148,324,7082,22985,5339,1832,329,3837,4000,6709	HMGB1,CASP7,CTNNB1,LMNB1,HMGB2,APC,TJP1,ACIN1,PLEC,DSP,BIRC2,KPNB1,LMNA,SPTAN1
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	0.611193317075213	-0.492341975294294	26	7	0.00307557117750439	2276	8202	1147,3146,8517,4791,5970,3551,23220	CHUK,HMGB1,IKBKG,NFKB2,RELA,IKBKB,DTX4
R-HSA-912694	Regulation of IFNA signaling	0.611193317075213	-0.492341975294294	26	7	0.00307557117750439	2276	8202	5770,8651,7297,11274,6773,6772,5781	PTPN1,SOCS1,TYK2,USP18,STAT2,STAT1,PTPN11
R-HSA-162791	Attachment of GPI anchor to uPAR	0.621003389584253	-0.476418738795836	7	2	0.000878734622144112	2276	8202	128869,51604	PIGU,PIGT
R-HSA-426117	Cation-coupled Chloride cotransporters	0.621003389584253	-0.476418738795836	7	2	0.000878734622144112	2276	8202	9990,57468	SLC12A6,SLC12A5
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.621003389584253	-0.476418738795836	7	2	0.000878734622144112	2276	8202	3280,3516	HES1,RBPJ
R-HSA-163767	PP2A-mediated dephosphorylation of key metabolic factors	0.621003389584253	-0.476418738795836	7	2	0.000878734622144112	2276	8202	5518,5528	PPP2R1A,PPP2R5D
R-HSA-448706	Interleukin-1 processing	0.621003389584253	-0.476418738795836	7	2	0.000878734622144112	2276	8202	4791,5970	NFKB2,RELA
R-HSA-426496	Post-transcriptional silencing by small RNAs	0.621003389584253	-0.476418738795836	7	2	0.000878734622144112	2276	8202	23112,192669	TNRC6B,AGO3
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected purine	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	4595	MUTYH
R-HSA-1368071	NR1D1 (REV-ERBA) represses gene expression	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	9572	NR1D1
R-HSA-964827	Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	10905	MAN1A2
R-HSA-191650	Regulation of gap junction activity	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	7082	TJP1
R-HSA-77285	Beta oxidation of myristoyl-CoA to lauroyl-CoA	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	3032	HADHB
R-HSA-191647	c-src mediated regulation of Cx43 function and closure of gap junctions	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	7082	TJP1
R-HSA-1299308	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	3775	KCNK1
R-HSA-73843	5-Phosphoribose 1-diphosphate biosynthesis	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	5631	PRPS1
R-HSA-163282	Mitochondrial transcription initiation	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	64216	TFB2M
R-HSA-428359	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	10643	IGF2BP3
R-HSA-379401	Dopamine clearance from the synaptic cleft	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	4128	MAOA
R-HSA-198745	Signalling to STAT3	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	6774	STAT3
R-HSA-844455	The NLRP1 inflammasome	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	598	BCL2L1
R-HSA-177539	Autointegration results in viral DNA circles	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	3159	HMGA1
R-HSA-77305	Beta oxidation of palmitoyl-CoA to myristoyl-CoA	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	3032	HADHB
R-HSA-111446	Activation of BIM and translocation to mitochondria	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	8655	DYNLL1
R-HSA-77352	Beta oxidation of butanoyl-CoA to acetyl-CoA	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	3033	HADH
R-HSA-350864	Regulation of thyroid hormone activity	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	1734	DIO2
R-HSA-110331	Cleavage of the damaged purine	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	4595	MUTYH
R-HSA-3249367	STAT6-mediated induction of chemokines	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	6778	STAT6
R-HSA-351200	Interconversion of polyamines	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	6303	SAT1
R-HSA-175567	Integration of viral DNA into host genomic DNA	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	3159	HMGA1
R-HSA-964975	Vitamins B6 activation to pyridoxal phosphate	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	55163	PNPO
R-HSA-139910	Activation of BMF and translocation to mitochondria	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	90427	BMF
R-HSA-1483248	Synthesis of PIPs at the ER membrane	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	22908	SACM1L
R-HSA-5250992	Toxicity of botulinum toxin type E (BoNT/E)	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	6616	SNAP25
R-HSA-73927	Depurination	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	4595	MUTYH
R-HSA-5635851	GLI proteins bind promoters of Hh responsive genes to promote transcription	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	2735	GLI1
R-HSA-1234162	Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	55662	HIF1AN
R-HSA-5250989	Toxicity of botulinum toxin type G (BoNT/G)	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	6843	VAMP1
R-HSA-880009	Interconversion of 2-oxoglutarate and 2-hydroxyglutarate	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	79944	L2HGDH
R-HSA-5250971	Toxicity of botulinum toxin type C (BoNT/C)	0.622892975303236	-0.473380564192537	3	1	0.000439367311072056	2276	8202	6616	SNAP25
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	0.623305164030393	-0.472719050217868	86	23	0.0101054481546573	2276	8202	10163,5058,10152,10451,8936,4690,3326,10096,4627,10552,4641,5581,55845,998,63916,8976,5296,3320,10097,10768,10109,147179,10006	WASF2,PAK1,ABI2,VAV3,WASF1,NCK1,HSP90AB1,ACTR3,MYH9,ARPC1A,MYO1C,PRKCE,BRK1,CDC42,ELMO2,WASL,PIK3R2,HSP90AA1,ACTR2,AHCYL1,ARPC2,WIPF2,ABI1
R-HSA-416482	G alpha (12/13) signalling events	0.626512606502999	-0.46758638273673	75	20	0.00878734622144113	2276	8202	10451,2788,1894,23365,2783,27237,2768,998,59345,5296,9138,8503,9181,51764,9828,2787,9475,23229,64857,6453	VAV3,GNG7,ECT2,ARHGEF12,GNB2,ARHGEF16,GNA12,CDC42,GNB4,PIK3R2,ARHGEF1,PIK3R3,ARHGEF2,GNG13,ARHGEF17,GNG5,ROCK2,ARHGEF9,PLEKHG2,ITSN1
R-HSA-351906	Apoptotic cleavage of cell adhesion  proteins	0.626586616012849	-0.46746826039078	11	3	0.00131810193321617	2276	8202	7082,1499,1832	TJP1,CTNNB1,DSP
R-HSA-196757	Metabolism of folate and pterines	0.626586616012849	-0.46746826039078	11	3	0.00131810193321617	2276	8202	200895,6470,2356	DHFRL1,SHMT1,FPGS
R-HSA-975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	0.626586616012849	-0.46746826039078	11	3	0.00131810193321617	2276	8202	7335,170506,7334	UBE2V1,DHX36,UBE2N
R-HSA-1266695	Interleukin-7 signaling	0.626586616012849	-0.46746826039078	11	3	0.00131810193321617	2276	8202	8503,6777,5296	PIK3R3,STAT5B,PIK3R2
R-HSA-200425	Import of palmitoyl-CoA into the mitochondrial matrix	0.626586616012849	-0.46746826039078	11	3	0.00131810193321617	2276	8202	5467,51422,5565	PPARD,PRKAG2,PRKAB2
R-HSA-71240	Tryptophan catabolism	0.626586616012849	-0.46746826039078	11	3	0.00131810193321617	2276	8202	56267,883,8942	CCBL2,CCBL1,KYNU
R-HSA-189451	Heme biosynthesis	0.626586616012849	-0.46746826039078	11	3	0.00131810193321617	2276	8202	3145,210,5498	HMBS,ALAD,PPOX
R-HSA-5693537	Resolution of D-Loop Structures	0.630297469695447	-0.461563396915923	34	9	0.00395430579964851	2276	8202	9156,5889,675,83990,7516,7156,7517,641,348654	EXO1,RAD51C,BRCA2,BRIP1,XRCC2,TOP3A,XRCC3,BLM,GEN1
R-HSA-3214841	PKMTs methylate histone lysines	0.630954053148476	-0.460522235021648	64	17	0.00746924428822496	2276	8202	84661,5931,8367,8350,8363,11091,8368,5929,8360,8365,8362,8364,387893,653604,9757,9070,4297	DPY30,RBBP7,HIST1H4E,HIST1H3A,HIST1H4J,WDR5,HIST1H4L,RBBP5,HIST1H4D,HIST1H4H,HIST1H4K,HIST1H4C,KMT5A,HIST2H3D,KMT2B,ASH2L,KMT2A
R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.633641114650963	-0.456272550039616	15	4	0.00175746924428822	2276	8202	3845,3320,6464,11140	KRAS,HSP90AA1,SHC1,CDC37
R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.633641114650963	-0.456272550039616	15	4	0.00175746924428822	2276	8202	3845,3320,6464,11140	KRAS,HSP90AA1,SHC1,CDC37
R-HSA-5674135	MAP2K and MAPK activation	0.638767727342797	-0.448214384670789	38	10	0.00439367311072056	2276	8202	673,2335,369,7094,5894,28956,5604,3845,7414,4140	BRAF,FN1,ARAF,TLN1,RAF1,LAMTOR2,MAP2K1,KRAS,VCL,MARK3
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor	0.640940462788913	-0.444818708139812	19	5	0.00219683655536028	2276	8202	51764,2783,59345,2787,2788	GNG13,GNB2,GNB4,GNG5,GNG7
R-HSA-389977	Post-chaperonin tubulin folding pathway	0.640940462788913	-0.444818708139812	19	5	0.00219683655536028	2276	8202	6903,1155,10383,6905,10381	TBCC,TBCB,TUBB4B,TBCE,TUBB3
R-HSA-201451	Signaling by BMP	0.648128146533	-0.433666845185829	23	6	0.00263620386643234	2276	8202	7323,9765,659,4091,9241,4092	UBE2D3,ZFYVE16,BMPR2,SMAD6,NOG,SMAD7
R-HSA-354192	Integrin alphaIIb beta3 signaling	0.655089001250959	-0.422984172805249	27	7	0.00307557117750439	2276	8202	5170,5770,10411,2335,6464,7094,11069	PDPK1,PTPN1,RAPGEF3,FN1,SHC1,TLN1,RAPGEF4
R-HSA-180024	DARPP-32 events	0.655089001250959	-0.422984172805249	27	7	0.00307557117750439	2276	8202	805,5144,5141,5566,5518,5528,5573	CALM2,PDE4D,PDE4A,PRKACA,PPP2R1A,PPP2R5D,PRKAR1A
R-HSA-2682334	EPH-Ephrin signaling	0.660928430230942	-0.414109719983621	95	25	0.0109841827768014	2276	8202	5058,10451,51107,10096,4627,2044,10552,4628,10627,1969,998,8976,160,1213,4637,163,1942,3320,6386,10097,10109,1175,23385,9475,6453	PAK1,VAV3,APH1A,ACTR3,MYH9,EPHA5,ARPC1A,MYH10,MYL12A,EPHA2,CDC42,WASL,AP2A1,CLTC,MYL6,AP2B1,EFNA1,HSP90AA1,SDCBP,ACTR2,ARPC2,AP2S1,NCSTN,ROCK2,ITSN1
R-HSA-5654733	Negative regulation of FGFR4 signaling	0.661790071840196	-0.412806885359652	31	8	0.00351493848857645	2276	8202	7311,673,7314,5518,6233,10253,7316,5781	UBA52,BRAF,UBB,PPP2R1A,RPS27A,SPRY2,UBC,PTPN11
R-HSA-70171	Glycolysis	0.661790071840196	-0.412806885359652	31	8	0.00351493848857645	2276	8202	2597,5230,5208,5518,226,5209,5224,5528	GAPDH,PGK1,PFKFB2,PPP2R1A,ALDOA,PFKFB3,PGAM2,PPP2R5D
R-HSA-977225	Amyloid formation	0.671906983784027	-0.397635365027559	88	23	0.0101054481546573	2276	8202	3015,723790,8367,26088,85236,3021,8350,567,8340,8363,8368,8347,8360,6622,8365,8362,3012,8364,3014,653604,128312,3017,8331	H2AFZ,HIST2H2AA4,HIST1H4E,GGA1,HIST1H2BK,H3F3B,HIST1H3A,B2M,HIST1H2BL,HIST1H4J,HIST1H4L,HIST1H2BC,HIST1H4D,SNCA,HIST1H4H,HIST1H4K,HIST1H2AE,HIST1H4C,H2AFX,HIST2H3D,HIST3H2BB,HIST1H2BD,HIST1H2AJ
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.68201886238202	-0.382697964069493	137	36	0.015817223198594	2276	8202	11311,7157,3831,29127,8350,11004,25942,5566,23028,3833,7465,998,829,653604,3660,3717,3835,81928,10112,23186,10362,3021,5868,3832,8165,3796,5889,24137,55669,64145,25970,1062,23764,3066,5573,11216	VPS45,TP53,KLC1,RACGAP1,HIST1H3A,KIF2C,SIN3A,PRKACA,KDM1A,KIFC1,WEE1,CDC42,CAPZA1,HIST2H3D,IRF2,JAK2,KIF22,CABLES2,KIF20A,RCOR1,HMG20B,H3F3B,RAB5A,KIF11,AKAP1,KIF2A,RAD51C,KIF4A,MFN1,RBSN,SH2B1,CENPE,MAFF,HDAC2,PRKAR1A,AKAP10
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.688279321419533	-0.373560533005243	16	4	0.00175746924428822	2276	8202	3159,4001,7290,7157	HMGA1,LMNB1,HIRA,TP53
R-HSA-5218859	Regulated Necrosis	0.688279321419533	-0.373560533005243	16	4	0.00175746924428822	2276	8202	330,7186,329,8772	BIRC3,TRAF2,BIRC2,FADD
R-HSA-416993	Trafficking of GluR2-containing AMPA receptors	0.688279321419533	-0.373560533005243	16	4	0.00175746924428822	2276	8202	163,1175,160,9463	AP2B1,AP2S1,AP2A1,PICK1
R-HSA-5213460	RIPK1-mediated regulated necrosis	0.688279321419533	-0.373560533005243	16	4	0.00175746924428822	2276	8202	330,7186,329,8772	BIRC3,TRAF2,BIRC2,FADD
R-HSA-418217	G beta:gamma signalling through PLC beta	0.689663254531547	-0.371551837430408	20	5	0.00219683655536028	2276	8202	51764,2783,59345,2787,2788	GNG13,GNB2,GNB4,GNG5,GNG7
R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	0.689679620389125	-0.371528107496573	12	3	0.00131810193321617	2276	8202	5339,840,6709	PLEC,CASP7,SPTAN1
R-HSA-2197563	NOTCH2 intracellular domain regulates transcription	0.689679620389125	-0.371528107496573	12	3	0.00131810193321617	2276	8202	3280,3516,9794	HES1,RBPJ,MAML1
R-HSA-73621	Pyrimidine catabolism	0.689679620389125	-0.371528107496573	12	3	0.00131810193321617	2276	8202	30833,1890,7378	NT5C,TYMP,UPP1
R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.689679620389125	-0.371528107496573	12	3	0.00131810193321617	2276	8202	23649,5518,5422	POLA2,PPP2R1A,POLA1
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	0.69240540709446	-0.367583646504249	24	6	0.00263620386643234	2276	8202	4627,4637,23365,998,4628,9475	MYH9,MYL6,ARHGEF12,CDC42,MYH10,ROCK2
R-HSA-202040	G-protein activation	0.695861936111985	-0.362604005980378	28	7	0.00307557117750439	2276	8202	51764,2771,2773,2783,59345,2787,2788	GNG13,GNAI2,GNAI3,GNB2,GNB4,GNG5,GNG7
R-HSA-1483166	Synthesis of PA	0.695861936111985	-0.362604005980378	28	7	0.00307557117750439	2276	8202	81579,57678,10555,253558,56895,84803,10554	PLA2G12A,GPAM,AGPAT2,LCLAT1,AGPAT4,GPAT3,AGPAT1
R-HSA-196836	Vitamin C (ascorbate) metabolism	0.697712487367602	-0.359948170293139	8	2	0.000878734622144112	2276	8202	119391,1528	GSTO2,CYB5A
R-HSA-428643	Organic anion transporters	0.697712487367602	-0.359948170293139	8	2	0.000878734622144112	2276	8202	26503,1468	SLC17A5,SLC25A10
R-HSA-416550	Sema4D mediated inhibition of cell attachment and migration	0.697712487367602	-0.359948170293139	8	2	0.000878734622144112	2276	8202	4233,6237	MET,RRAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	0.697712487367602	-0.359948170293139	8	2	0.000878734622144112	2276	8202	23239,208	PHLPP1,AKT2
R-HSA-196783	Coenzyme A biosynthesis	0.697712487367602	-0.359948170293139	8	2	0.000878734622144112	2276	8202	80025,8034	PANK2,SLC25A16
R-HSA-77286	mitochondrial fatty acid beta-oxidation of saturated fatty acids	0.697712487367602	-0.359948170293139	8	2	0.000878734622144112	2276	8202	3033,3032	HADH,HADHB
R-HSA-193634	Axonal growth inhibition (RHOA activation)	0.697712487367602	-0.359948170293139	8	2	0.000878734622144112	2276	8202	57142,9138	RTN4,ARHGEF1
R-HSA-5654726	Negative regulation of FGFR1 signaling	0.699704541160527	-0.357097117097671	32	8	0.00351493848857645	2276	8202	7311,673,7314,5518,6233,10253,7316,5781	UBA52,BRAF,UBB,PPP2R1A,RPS27A,SPRY2,UBC,PTPN11
R-HSA-376176	Signaling by Robo receptor	0.699704541160527	-0.357097117097671	32	8	0.00351493848857645	2276	8202	5058,27,7408,10487,998,4690,23122,9901	PAK1,ABL2,VASP,CAP1,CDC42,NCK1,CLASP2,SRGAP3
R-HSA-1483257	Phospholipid metabolism	0.709761240385907	-0.34282664664857	146	38	0.0166959578207381	2276	8202	3636,84803,55500,10554,30849,162466,81579,10162,64900,8867,253558,1119,1040,51763,5298,9110,5296,23446,3032,8503,200576,8904,85465,5289,56895,50640,8394,79143,64850,55697,55361,8396,10555,201164,10400,22908,57678,5130	INPPL1,GPAT3,ETNK1,AGPAT1,PIK3R4,PHOSPHO1,PLA2G12A,LPCAT3,LPIN3,SYNJ1,LCLAT1,CHKA,CDS1,INPP5K,PI4KB,MTMR4,PIK3R2,SLC44A1,HADHB,PIK3R3,PIKFYVE,CPNE1,EPT1,PIK3C3,AGPAT4,PNPLA8,PIP5K1A,MBOAT7,ETNPPL,VAC14,PI4K2A,PIP4K2B,AGPAT2,PLD6,PEMT,SACM1L,GPAM,PCYT1A
R-HSA-446343	Localization of the PINCH-ILK-PARVIN complex to focal adhesions	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	3688	ITGB1
R-HSA-5250968	Toxicity of botulinum toxin type A (BoNT/A)	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	6616	SNAP25
R-HSA-5221030	TET1,2,3 and TDG demethylate DNA	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	6996	TDG
R-HSA-71262	Carnitine synthesis	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	6470	SHMT1
R-HSA-193144	Estrogen biosynthesis	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	51170	HSD17B11
R-HSA-210455	Astrocytic Glutamate-Glutamine Uptake And Metabolism	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	81539	SLC38A1
R-HSA-75072	mRNA Editing	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	103	ADAR
R-HSA-2473224	Antagonism of Activin by Follistatin	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	10272	FSTL3
R-HSA-211163	AKT-mediated inactivation of FOXO1A	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	208	AKT2
R-HSA-75896	Plasmalogen biosynthesis	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	84188	FAR1
R-HSA-112126	ALKBH3 mediated reversal of alkylation damage	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	10973	ASCC3
R-HSA-3878781	Glycogen storage disease type IV (GBE1)	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	2997	GYS1
R-HSA-433692	Proton-coupled monocarboxylate transport	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	6566	SLC16A1
R-HSA-140179	Amine Oxidase reactions	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	4128	MAOA
R-HSA-75108	Activation, myristolyation of BID and translocation to mitochondria	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	4836	NMT1
R-HSA-173107	Binding and entry of HIV virion	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	5478	PPIA
R-HSA-139915	Activation of PUMA and translocation to mitochondria	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	7157	TP53
R-HSA-442745	Activation of CaMK IV	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	805	CALM2
R-HSA-390650	Histamine receptors	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	3269	HRH1
R-HSA-167060	NGF processing	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	5125	PCSK5
R-HSA-112313	Neurotransmitter uptake and Metabolism In Glial Cells	0.727575935208342	-0.318036907090271	4	1	0.000439367311072056	2276	8202	81539	SLC38A1
R-HSA-500657	Presynaptic function of Kainate receptors	0.733662341263435	-0.309706381738481	21	5	0.00219683655536028	2276	8202	51764,2787,2783,59345,2788	GNG13,GNG5,GNB2,GNB4,GNG7
R-HSA-390918	Peroxisomal lipid metabolism	0.733662341263435	-0.309706381738481	21	5	0.00219683655536028	2276	8202	3295,84188,8310,51,10005	HSD17B4,FAR1,ACOX3,ACOX1,ACOT8
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	0.734762941811557	-0.308207359940231	33	8	0.00351493848857645	2276	8202	5432,5440,2649,57167,5434,6774,5430,5431	POLR2C,POLR2K,NR6A1,SALL4,POLR2E,STAT3,POLR2A,POLR2B
R-HSA-4085001	Sialic acid metabolism	0.734762941811557	-0.308207359940231	33	8	0.00351493848857645	2276	8202	6484,10825,6480,10020,6483,26503,10559,4758	ST3GAL4,NEU3,ST6GAL1,GNE,ST3GAL2,SLC17A5,SLC35A1,NEU1
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.734762941811557	-0.308207359940231	33	8	0.00351493848857645	2276	8202	8503,51763,8396,3636,8394,8867,5296,55361	PIK3R3,INPP5K,PIP4K2B,INPPL1,PIP5K1A,SYNJ1,PIK3R2,PI4K2A
R-HSA-156590	Glutathione conjugation	0.736743947698656	-0.305514872262471	37	9	0.00395430579964851	2276	8202	373156,2954,79017,119391,2729,4259,55748,2937,10327	GSTK1,GSTZ1,GGCT,GSTO2,GCLC,MGST3,CNDP2,GSS,AKR1A1
R-HSA-442729	CREB phosphorylation through the activation of CaMKII	0.736862133342186	-0.305354468956182	17	4	0.00175746924428822	2276	8202	1742,805,817,10142	DLG4,CALM2,CAMK2D,AKAP9
R-HSA-77289	Mitochondrial Fatty Acid Beta-Oxidation	0.736862133342186	-0.305354468956182	17	4	0.00175746924428822	2276	8202	3033,4594,1632,3032	HADH,MUT,ECI1,HADHB
R-HSA-442755	Activation of NMDA receptor upon glutamate binding and postsynaptic events	0.739102920165949	-0.30231809822366	41	10	0.00439367311072056	2276	8202	5170,805,817,10142,673,6196,6237,5894,1742,5566	PDPK1,CALM2,CAMK2D,AKAP9,BRAF,RPS6KA2,RRAS,RAF1,DLG4,PRKACA
R-HSA-193648	NRAGE signals death through JNK	0.741716090553487	-0.298788736321661	45	11	0.00483304042179262	2276	8202	572,10451,26574,1894,9181,23365,9828,23229,64857,6453,27237	BAD,VAV3,AATF,ECT2,ARHGEF2,ARHGEF12,ARHGEF17,ARHGEF9,PLEKHG2,ITSN1,ARHGEF16
R-HSA-211227	Activation of DNA fragmentation factor	0.744378712968133	-0.295205350850577	13	3	0.00131810193321617	2276	8202	3148,3146,3837	HMGB2,HMGB1,KPNB1
R-HSA-428790	Facilitative Na+-independent glucose transporters	0.744378712968133	-0.295205350850577	13	3	0.00131810193321617	2276	8202	154091,6517,29988	SLC2A12,SLC2A4,SLC2A8
R-HSA-171007	p38MAPK events	0.744378712968133	-0.295205350850577	13	3	0.00131810193321617	2276	8202	5900,3845,7867	RALGDS,KRAS,MAPKAPK3
R-HSA-140342	Apoptosis induced DNA fragmentation	0.744378712968133	-0.295205350850577	13	3	0.00131810193321617	2276	8202	3148,3146,3837	HMGB2,HMGB1,KPNB1
R-HSA-391160	Signal regulatory protein (SIRP) family interactions	0.744378712968133	-0.295205350850577	13	3	0.00131810193321617	2276	8202	2185,8935,5781	PTK2B,SKAP2,PTPN11
R-HSA-877300	Interferon gamma signaling	0.758201481069798	-0.276806122499281	92	23	0.0101054481546573	2276	8202	3122,4502,85363,3133,3134,23087,567,55128,3105,7341,817,5770,7726,8651,80263,6772,5781,10379,10612,3660,3717,3107,3459	HLA-DRA,MT2A,TRIM5,HLA-E,HLA-F,TRIM35,B2M,TRIM68,HLA-A,SUMO1,CAMK2D,PTPN1,TRIM26,SOCS1,TRIM45,STAT1,PTPN11,IRF9,TRIM3,IRF2,JAK2,HLA-C,IFNGR1
R-HSA-5666185	RHO GTPases Activate Rhotekin and Rhophilins	0.761050519921601	-0.27305553709317	9	2	0.000878734622144112	2276	8202	30851,6242	TAX1BP3,RTKN
R-HSA-2243919	Crosslinking of collagen fibrils	0.761050519921601	-0.27305553709317	9	2	0.000878734622144112	2276	8202	7092,4015	TLL1,LOX
R-HSA-389661	Glyoxylate metabolism and glycine degradation	0.761050519921601	-0.27305553709317	9	2	0.000878734622144112	2276	8202	1738,2653	DLD,GCSH
R-HSA-425381	Bicarbonate transporters	0.761050519921601	-0.27305553709317	9	2	0.000878734622144112	2276	8202	9497,6522	SLC4A7,SLC4A2
R-HSA-428543	Inactivation of Cdc42 and Rac	0.761050519921601	-0.27305553709317	9	2	0.000878734622144112	2276	8202	998,9901	CDC42,SRGAP3
R-HSA-70635	Urea cycle	0.761050519921601	-0.27305553709317	9	2	0.000878734622144112	2276	8202	384,1373	ARG2,CPS1
R-HSA-446107	Type I hemidesmosome assembly	0.761050519921601	-0.27305553709317	9	2	0.000878734622144112	2276	8202	5339,3914	PLEC,LAMB3
R-HSA-419408	Lysosphingolipid and LPA receptors	0.761050519921601	-0.27305553709317	9	2	0.000878734622144112	2276	8202	9170,9294	LPAR2,S1PR2
R-HSA-193697	p75NTR regulates axonogenesis	0.761050519921601	-0.27305553709317	9	2	0.000878734622144112	2276	8202	57142,9138	RTN4,ARHGEF1
R-HSA-196025	Formation of annular gap junctions	0.761050519921601	-0.27305553709317	9	2	0.000878734622144112	2276	8202	1213,1785	CLTC,DNM2
R-HSA-447041	CHL1 interactions	0.761050519921601	-0.27305553709317	9	2	0.000878734622144112	2276	8202	3312,3688	HSPA8,ITGB1
R-HSA-2428933	SHC-related events triggered by IGF1R	0.761050519921601	-0.27305553709317	9	2	0.000878734622144112	2276	8202	3845,6464	KRAS,SHC1
R-HSA-5654727	Negative regulation of FGFR2 signaling	0.766906164011411	-0.265390826674957	34	8	0.00351493848857645	2276	8202	7311,673,7314,5518,6233,10253,7316,5781	UBA52,BRAF,UBB,PPP2R1A,RPS27A,SPRY2,UBC,PTPN11
R-HSA-3928663	EPHA-mediated growth cone collapse	0.766906164011411	-0.265390826674957	34	8	0.00351493848857645	2276	8202	1969,4637,4627,2044,3320,1942,4628,9475	EPHA2,MYL6,MYH9,EPHA5,HSP90AA1,EFNA1,MYH10,ROCK2
R-HSA-1222556	ROS production in response to bacteria	0.766906164011411	-0.265390826674957	34	8	0.00351493848857645	2276	8202	51382,523,535,23545,51606,528,529,9114	ATP6V1D,ATP6V1A,ATP6V0A1,ATP6V0A2,ATP6V1H,ATP6V1C1,ATP6V1E1,ATP6V0D1
R-HSA-399719	Trafficking of AMPA receptors	0.767495002124977	-0.264623311431267	30	7	0.00307557117750439	2276	8202	59283,1742,163,817,1175,160,9463	CACNG8,DLG4,AP2B1,CAMK2D,AP2S1,AP2A1,PICK1
R-HSA-399721	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	0.767495002124977	-0.264623311431267	30	7	0.00307557117750439	2276	8202	59283,1742,163,817,1175,160,9463	CACNG8,DLG4,AP2B1,CAMK2D,AP2S1,AP2A1,PICK1
R-HSA-264876	Insulin processing	0.769295129348401	-0.262280599814554	26	6	0.00263620386643234	2276	8202	55770,64924,56605,1363,55676,60412	EXOC2,SLC30A5,ERO1B,CPE,SLC30A6,EXOC4
R-HSA-5223345	Miscellaneous transport and binding events	0.779480100309403	-0.249128119598622	18	4	0.00175746924428822	2276	8202	57185,81614,1497,84061	NIPAL3,NIPA2,CTNS,MAGT1
R-HSA-418885	DCC mediated attractive signaling	0.791079917586363	-0.234356282706956	14	3	0.00131810193321617	2276	8202	998,4690,8976	CDC42,NCK1,WASL
R-HSA-373755	Semaphorin interactions	0.799899922635149	-0.223268655845519	67	16	0.0070298769771529	2276	8202	5058,6237,7094,3326,4627,23365,4628,57556,998,1808,3688,2932,4637,3320,4233,9475	PAK1,RRAS,TLN1,HSP90AB1,MYH9,ARHGEF12,MYH10,SEMA6A,CDC42,DPYSL2,ITGB1,GSK3B,MYL6,HSP90AA1,MET,ROCK2
R-HSA-1368082	RORA activates gene expression	0.801925451654822	-0.220739628484876	27	6	0.00263620386643234	2276	8202	23411,6907,9575,10891,9572,406	SIRT1,TBL1X,CLOCK,PPARGC1A,NR1D1,ARNTL
R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	1499	CTNNB1
R-HSA-111932	CaMK IV-mediated phosphorylation of CREB	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	805	CALM2
R-HSA-140834	Extrinsic Pathway of Fibrin Clot Formation	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	2152	F3
R-HSA-75157	FasL/ CD95L signaling	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	8772	FADD
R-HSA-167827	The proton buffering model	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	7351	UCP2
R-HSA-163358	PKA-mediated phosphorylation of key metabolic factors	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	5566	PRKACA
R-HSA-5250981	Toxicity of botulinum toxin type F (BoNT/F)	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	6843	VAMP1
R-HSA-70370	Galactose catabolism	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	2582	GALE
R-HSA-166187	Mitochondrial Uncoupling Proteins	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	7351	UCP2
R-HSA-427652	Sodium-coupled phosphate cotransporters	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	6574	SLC20A1
R-HSA-71032	Propionyl-CoA catabolism	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	4594	MUT
R-HSA-5250955	Toxicity of botulinum toxin type D (BoNT/D)	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	6843	VAMP1
R-HSA-964739	N-glycan trimming and elongation in the cis-Golgi	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	10905	MAN1A2
R-HSA-112303	Electric Transmission Across Gap Junctions	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	24145	PANX1
R-HSA-1169092	Activation of RAS in B cells	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	3845	KRAS
R-HSA-112307	Transmission across Electrical Synapses	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	24145	PANX1
R-HSA-167826	The fatty acid cycling model	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	7351	UCP2
R-HSA-3065676	SUMO is conjugated to E1 (UBA2:SAE1)	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	7341	SUMO1
R-HSA-446210	Synthesis of UDP-N-acetyl-glucosamine	0.80320867142257	-0.219140734009112	5	1	0.000439367311072056	2276	8202	6675	UAP1
R-HSA-168249	Innate Immune System	0.807360274093537	-0.213985274035922	752	199	0.0874340949033392	2276	8202	23291,8936,4763,5589,51728,329,5606,805,5707,5696,6196,998,1499,63916,5296,1785,5971,11221,3660,55703,10097,147179,5094,64223,1604,7311,4690,208,842,9140,7335,572,64145,5719,6233,5714,4296,5690,5527,2932,5705,5528,5700,284,7323,3146,5689,5693,2335,7094,5440,3133,171568,5245,30849,5713,4205,23239,5715,1847,4641,5581,3725,966,5601,829,3107,5598,5686,10621,5058,10152,7867,5702,51295,10892,5682,3845,2002,10552,5691,7520,369,51082,5434,10109,64135,192669,10163,10142,161742,200734,1540,1848,79671,2475,5894,10096,5604,4627,1147,5526,598,5566,8411,5687,6464,55845,8651,5518,5300,3551,28956,10628,835,1027,8503,253260,10768,4791,5970,7414,1386,10006,54476,51428,8767,330,2931,115004,3326,5695,1742,837,725,8517,817,5529,1650,5709,8976,6778,2547,9474,9861,10454,4343,7334,5573,55593,23112,673,7184,257397,7186,8887,51191,80143,567,84335,9252,9491,24145,466,661,5781,3717,145957,5717,3320,2065,6885,7314,1843,5694,6709,6199,5170,10451,5289,5692,5609,7128,3164,246330,5710,2353,4140,11128,7316,8772,10910,5608,7322,84078,23220,10197,170506,8945	FBXW11,WASF1,NF1,PRKCSH,POLR3K,BIRC2,MAP2K3,CALM2,PSMD1,PSMB8,RPS6KA2,CDC42,CTNNB1,ELMO2,PIK3R2,DNM2,RELB,DUSP10,IRF2,POLR3B,ACTR2,WIPF2,PCBP2,MLST8,CD55,UBA52,NCK1,AKT2,CASP9,ATG12,UBE2V1,BAD,RBSN,PSMD13,RPS27A,PSMD8,MAP3K11,PSMB2,PPP2R5C,GSK3B,PSMC5,PPP2R5D,PSMC1,ANGPT1,UBE2D3,HMGB1,PSMB1,PSMB5,FN1,TLN1,POLR2K,HLA-E,POLR3H,PHB,PIK3R4,PSMD7,MEF2A,PHLPP1,PSMD9,DUSP5,MYO1C,PRKCE,JUN,CD59,MAPK9,CAPZA1,HLA-C,MAPK7,PSMA5,POLR3F,PAK1,ABI2,MAPKAPK3,PSMC3,ECSIT,MALT1,PSMA1,KRAS,ELK1,ARPC1A,PSMB3,XRCC5,ARAF,POLR1D,POLR2E,ARPC2,IFIH1,AGO3,WASF2,AKAP9,SPRED1,SPRED2,CYLD,DUSP6,NLRX1,MTOR,RAF1,ACTR3,MAP2K1,MYH9,CHUK,PPP2R5B,BCL2L1,PRKACA,EEA1,PSMA6,SHC1,BRK1,SOCS1,PPP2R1A,PIN1,IKBKB,LAMTOR2,TXNIP,CASP2,CDKN1B,PIK3R3,RICTOR,AHCYL1,NFKB2,RELA,VCL,ATF2,ABI1,RNF216,DDX41,RIPK2,BIRC3,GSK3A,MB21D1,HSP90AB1,PSMB7,DLG4,CASP4,C4BPB,IKBKG,CAMK2D,PPP2R5E,DDOST,PSMD3,WASL,STAT6,XRCC6,ATG5,PSMD6,TAB1,MOV10,UBE2N,PRKAR1A,OTUD5,TNRC6B,BRAF,HSP90B1,TAB3,TRAF2,TAX1BP1,HERC5,SIKE1,B2M,AKT1S1,RPS6KA5,PSMF1,PANX1,ATF1,POLR3D,PTPN11,JAK2,NRG4,PSMD11,HSP90AA1,ERBB3,MAP3K7,UBB,DUSP1,PSMB6,SPTAN1,RPS6KB2,PDPK1,VAV3,PIK3C3,PSMB4,MAP2K7,TNFAIP3,NR4A1,PELI3,PSMD4,FOS,MARK3,POLR3A,UBC,FADD,SUGT1,MAP2K6,UBE2D2,KBTBD7,DTX4,PSME3,DHX36,BTRC
R-HSA-428930	Thromboxane signalling through TP receptor	0.807592573739022	-0.213697588054998	23	5	0.00219683655536028	2276	8202	51764,2783,59345,2787,2788	GNG13,GNB2,GNB4,GNG5,GNG7
R-HSA-211976	Endogenous sterols	0.807592573739022	-0.213697588054998	23	5	0.00219683655536028	2276	8202	1595,112812,10858,2232,1545	CYP51A1,FDX1L,CYP46A1,FDXR,CYP1B1
R-HSA-168799	Neurotoxicity of clostridium toxins	0.812528616042619	-0.207604145653683	10	2	0.000878734622144112	2276	8202	6616,6843	SNAP25,VAMP1
R-HSA-209968	Thyroxine biosynthesis	0.812528616042619	-0.207604145653683	10	2	0.000878734622144112	2276	8202	1081,1734	CGA,DIO2
R-HSA-549127	Organic cation transport	0.812528616042619	-0.207604145653683	10	2	0.000878734622144112	2276	8202	6583,5002	SLC22A4,SLC22A18
R-HSA-442380	Zinc influx into cells by the SLC39 gene family	0.812528616042619	-0.207604145653683	10	2	0.000878734622144112	2276	8202	64116,27173	SLC39A8,SLC39A1
R-HSA-430116	GP1b-IX-V activation signalling	0.812528616042619	-0.207604145653683	10	2	0.000878734622144112	2276	8202	7534,5894	YWHAZ,RAF1
R-HSA-190873	Gap junction degradation	0.812528616042619	-0.207604145653683	10	2	0.000878734622144112	2276	8202	1213,1785	CLTC,DNM2
R-HSA-2161522	Abacavir transport and metabolism	0.812528616042619	-0.207604145653683	10	2	0.000878734622144112	2276	8202	2987,5105	GUK1,PCK1
R-HSA-1855167	Synthesis of pyrophosphates in the cytosol	0.812528616042619	-0.207604145653683	10	2	0.000878734622144112	2276	8202	64768,9807	IPPK,IP6K1
R-HSA-418889	Ligand-independent caspase activation via DCC	0.812528616042619	-0.207604145653683	10	2	0.000878734622144112	2276	8202	842,1613	CASP9,DAPK3
R-HSA-5687613	Diseases associated with surfactant metabolism	0.812528616042619	-0.207604145653683	10	2	0.000878734622144112	2276	8202	7270,29080	TTF1,CCDC59
R-HSA-442982	Ras activation uopn Ca2+ infux through NMDA receptor	0.81642400364229	-0.202821446663031	19	4	0.00175746924428822	2276	8202	1742,805,817,10142	DLG4,CALM2,CAMK2D,AKAP9
R-HSA-888590	GABA synthesis, release, reuptake and degradation	0.81642400364229	-0.202821446663031	19	4	0.00175746924428822	2276	8202	80331,6616,3312,5864	DNAJC5,SNAP25,HSPA8,RAB3A
R-HSA-392451	G beta:gamma signalling through PI3Kgamma	0.81795766282069	-0.200944700661748	48	11	0.00483304042179262	2276	8202	5170,6464,208,59345,2788,5296,8503,3717,51764,2787,2783	PDPK1,SHC1,AKT2,GNB4,GNG7,PIK3R2,PIK3R3,JAK2,GNG13,GNG5,GNB2
R-HSA-75109	Triglyceride Biosynthesis	0.819450538153874	-0.199121238746818	68	16	0.0070298769771529	2276	8202	60481,9374,2710,23597,56895,79993,84803,10554,64900,253558,10555,47,57678,55856,10005,6576	ELOVL5,PPT2,GK,ACOT9,AGPAT4,ELOVL7,GPAT3,AGPAT1,LPIN3,LCLAT1,AGPAT2,ACLY,GPAM,ACOT13,ACOT8,SLC25A1
R-HSA-388841	Costimulation by the CD28 family	0.819450538153874	-0.199121238746818	68	16	0.0070298769771529	2276	8202	3122,5058,5170,2475,208,5526,5529,998,5518,5296,5781,8503,5527,253260,5528,64223	HLA-DRA,PAK1,PDPK1,MTOR,AKT2,PPP2R5B,PPP2R5E,CDC42,PPP2R1A,PIK3R2,PTPN11,PIK3R3,PPP2R5C,RICTOR,PPP2R5D,MLST8
R-HSA-1251985	Nuclear signaling by ERBB4	0.820249638141405	-0.198146548297494	40	9	0.00395430579964851	2276	8202	6868,51107,25970,5781,145957,6777,3717,23385,8945	ADAM17,APH1A,SH2B1,PTPN11,NRG4,STAT5B,JAK2,NCSTN,BTRC
R-HSA-1660662	Glycosphingolipid metabolism	0.820249638141405	-0.198146548297494	40	9	0.00395430579964851	2276	8202	55512,10825,6609,2629,427,25870,55627,4758,2760	SMPD3,NEU3,SMPD1,GBA,ASAH1,SUMF2,SMPD4,NEU1,GM2A
R-HSA-1660661	Sphingolipid de novo biosynthesis	0.822541442237665	-0.195356411912638	36	8	0.00351493848857645	2276	8202	1455,221,91012,10087,10558,56848,9517,224	CSNK1G2,ALDH3B1,CERS5,COL4A3BP,SPTLC1,SPHK2,SPTLC2,ALDH3A2
R-HSA-392518	Signal amplification	0.825939505165298	-0.191233746441885	32	7	0.00307557117750439	2276	8202	51764,2771,2773,2783,59345,2787,2788	GNG13,GNAI2,GNAI3,GNB2,GNB4,GNG5,GNG7
R-HSA-451326	Activation of Kainate Receptors upon glutamate binding	0.825939505165298	-0.191233746441885	32	7	0.00307557117750439	2276	8202	1742,805,51764,2787,2783,59345,2788	DLG4,CALM2,GNG13,GNG5,GNB2,GNB4,GNG7
R-HSA-1483206	Glycerophospholipid biosynthesis	0.828336808094306	-0.188335434245854	96	23	0.0101054481546573	2276	8202	8904,85465,56895,84803,55500,10554,162466,81579,10162,50640,64900,253558,64850,79143,1119,1040,10555,201164,10400,23446,3032,57678,5130	CPNE1,EPT1,AGPAT4,GPAT3,ETNK1,AGPAT1,PHOSPHO1,PLA2G12A,LPCAT3,PNPLA8,LPIN3,LCLAT1,ETNPPL,MBOAT7,CHKA,CDS1,AGPAT2,PLD6,PEMT,SLC44A1,HADHB,GPAM,PCYT1A
R-HSA-975577	N-Glycan antennae elongation	0.830439618321901	-0.185800057783377	15	3	0.00131810193321617	2276	8202	6484,6480,8704	ST3GAL4,ST6GAL1,B4GALT2
R-HSA-5602358	Diseases associated with the TLR signaling cascade	0.83790498600367	-0.176850566785459	24	5	0.00219683655536028	2276	8202	1147,8517,4791,5970,3551	CHUK,IKBKG,NFKB2,RELA,IKBKB
R-HSA-5260271	Diseases of Immune System	0.83790498600367	-0.176850566785459	24	5	0.00219683655536028	2276	8202	1147,8517,4791,5970,3551	CHUK,IKBKG,NFKB2,RELA,IKBKB
R-HSA-375165	NCAM signaling for neurite out-growth	0.845798810930616	-0.167473759796456	266	67	0.0294376098418278	2276	8202	161742,10142,200734,1848,4763,5894,5604,5526,805,5707,5687,5696,6464,5518,28956,11221,7414,7311,5695,1742,5529,817,5719,6233,5714,5709,4296,5690,5527,784,9861,5705,5700,284,5528,5689,673,5693,2335,7094,5245,5713,5715,9252,1847,9491,783,3717,145957,5717,2065,7314,5686,6709,1843,5694,5692,5702,5682,3845,5710,4140,7316,5691,369,84078,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,PPP2R5B,CALM2,PSMD1,PSMA6,PSMB8,SHC1,PPP2R1A,LAMTOR2,DUSP10,VCL,UBA52,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,RPS27A,PSMD8,PSMD3,MAP3K11,PSMB2,PPP2R5C,CACNB3,PSMD6,PSMC5,PSMC1,ANGPT1,PPP2R5D,PSMB1,BRAF,PSMB5,FN1,TLN1,PHB,PSMD7,PSMD9,RPS6KA5,DUSP5,PSMF1,CACNB2,JAK2,NRG4,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,PSMC3,PSMA1,KRAS,PSMD4,MARK3,UBC,PSMB3,ARAF,KBTBD7,PSME3
R-HSA-3000170	Syndecan interactions	0.848114190923029	-0.164739993148613	20	4	0.00175746924428822	2276	8202	87,6382,3688,51399	ACTN1,SDC1,ITGB1,TRAPPC4
R-HSA-381771	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	0.848114190923029	-0.164739993148613	20	4	0.00175746924428822	2276	8202	51764,60559,1499,6934	GNG13,SPCS3,CTNNB1,TCF7L2
R-HSA-163359	Glucagon signaling in metabolic regulation	0.85048704145113	-0.161946103651326	33	7	0.00307557117750439	2276	8202	51764,5566,2783,59345,2787,2788,5573	GNG13,PRKACA,GNB2,GNB4,GNG5,GNG7,PRKAR1A
R-HSA-71182	Phenylalanine and tyrosine catabolism	0.8538490604941	-0.158000844966763	11	2	0.000878734622144112	2276	8202	2954,883	GSTZ1,CCBL1
R-HSA-5625970	RHO GTPases activate KTN1	0.8538490604941	-0.158000844966763	11	2	0.000878734622144112	2276	8202	3831,998	KLC1,CDC42
R-HSA-3371378	Regulation by c-FLIP	0.8538490604941	-0.158000844966763	11	2	0.000878734622144112	2276	8202	7186,8772	TRAF2,FADD
R-HSA-1980148	Signaling by NOTCH3	0.8538490604941	-0.158000844966763	11	2	0.000878734622144112	2276	8202	51107,23385	APH1A,NCSTN
R-HSA-5218900	CASP8 activity is inhibited	0.8538490604941	-0.158000844966763	11	2	0.000878734622144112	2276	8202	7186,8772	TRAF2,FADD
R-HSA-69416	Dimerization of procaspase-8	0.8538490604941	-0.158000844966763	11	2	0.000878734622144112	2276	8202	7186,8772	TRAF2,FADD
R-HSA-1980150	Signaling by NOTCH4	0.8538490604941	-0.158000844966763	11	2	0.000878734622144112	2276	8202	51107,23385	APH1A,NCSTN
R-HSA-3299685	Detoxification of Reactive Oxygen Species	0.856287143567967	-0.155149510997108	29	6	0.00263620386643234	2276	8202	7296,54205,25828,5034,493869,5052	TXNRD1,CYCS,TXN2,P4HB,GPX8,PRDX1
R-HSA-1250342	PI3K events in ERBB4 signaling	0.857302027814718	-0.153964997950034	98	23	0.0101054481546573	2276	8202	5170,23112,2931,2475,3164,208,842,1147,84335,23239,572,5296,5781,1027,2932,8503,145957,253260,2065,4343,192669,6199,64223	PDPK1,TNRC6B,GSK3A,MTOR,NR4A1,AKT2,CASP9,CHUK,AKT1S1,PHLPP1,BAD,PIK3R2,PTPN11,CDKN1B,GSK3B,PIK3R3,NRG4,RICTOR,ERBB3,MOV10,AGO3,RPS6KB2,MLST8
R-HSA-5654720	PI-3K cascade:FGFR4	0.857302027814718	-0.153964997950034	98	23	0.0101054481546573	2276	8202	5170,23112,2931,2475,3164,208,842,1147,84335,23239,572,5296,5781,1027,2932,8503,145957,253260,2065,4343,192669,6199,64223	PDPK1,TNRC6B,GSK3A,MTOR,NR4A1,AKT2,CASP9,CHUK,AKT1S1,PHLPP1,BAD,PIK3R2,PTPN11,CDKN1B,GSK3B,PIK3R3,NRG4,RICTOR,ERBB3,MOV10,AGO3,RPS6KB2,MLST8
R-HSA-5654689	PI-3K cascade:FGFR1	0.857302027814718	-0.153964997950034	98	23	0.0101054481546573	2276	8202	5170,23112,2931,2475,3164,208,842,1147,84335,23239,572,5296,5781,1027,2932,8503,145957,253260,2065,4343,192669,6199,64223	PDPK1,TNRC6B,GSK3A,MTOR,NR4A1,AKT2,CASP9,CHUK,AKT1S1,PHLPP1,BAD,PIK3R2,PTPN11,CDKN1B,GSK3B,PIK3R3,NRG4,RICTOR,ERBB3,MOV10,AGO3,RPS6KB2,MLST8
R-HSA-5654695	PI-3K cascade:FGFR2	0.857302027814718	-0.153964997950034	98	23	0.0101054481546573	2276	8202	5170,23112,2931,2475,3164,208,842,1147,84335,23239,572,5296,5781,1027,2932,8503,145957,253260,2065,4343,192669,6199,64223	PDPK1,TNRC6B,GSK3A,MTOR,NR4A1,AKT2,CASP9,CHUK,AKT1S1,PHLPP1,BAD,PIK3R2,PTPN11,CDKN1B,GSK3B,PIK3R3,NRG4,RICTOR,ERBB3,MOV10,AGO3,RPS6KB2,MLST8
R-HSA-5654710	PI-3K cascade:FGFR3	0.857302027814718	-0.153964997950034	98	23	0.0101054481546573	2276	8202	5170,23112,2931,2475,3164,208,842,1147,84335,23239,572,5296,5781,1027,2932,8503,145957,253260,2065,4343,192669,6199,64223	PDPK1,TNRC6B,GSK3A,MTOR,NR4A1,AKT2,CASP9,CHUK,AKT1S1,PHLPP1,BAD,PIK3R2,PTPN11,CDKN1B,GSK3B,PIK3R3,NRG4,RICTOR,ERBB3,MOV10,AGO3,RPS6KB2,MLST8
R-HSA-1257604	PIP3 activates AKT signaling	0.857302027814718	-0.153964997950034	98	23	0.0101054481546573	2276	8202	5170,23112,2931,2475,3164,208,842,1147,84335,23239,572,5296,5781,1027,2932,8503,145957,253260,2065,4343,192669,6199,64223	PDPK1,TNRC6B,GSK3A,MTOR,NR4A1,AKT2,CASP9,CHUK,AKT1S1,PHLPP1,BAD,PIK3R2,PTPN11,CDKN1B,GSK3B,PIK3R3,NRG4,RICTOR,ERBB3,MOV10,AGO3,RPS6KB2,MLST8
R-HSA-1963642	PI3K events in ERBB2 signaling	0.857302027814718	-0.153964997950034	98	23	0.0101054481546573	2276	8202	5170,23112,2931,2475,3164,208,842,1147,84335,23239,572,5296,5781,1027,2932,8503,145957,253260,2065,4343,192669,6199,64223	PDPK1,TNRC6B,GSK3A,MTOR,NR4A1,AKT2,CASP9,CHUK,AKT1S1,PHLPP1,BAD,PIK3R2,PTPN11,CDKN1B,GSK3B,PIK3R3,NRG4,RICTOR,ERBB3,MOV10,AGO3,RPS6KB2,MLST8
R-HSA-193670	p75NTR negatively regulates cell cycle via SC1	0.857850255395733	-0.153325722236674	6	1	0.000439367311072056	2276	8202	3066	HDAC2
R-HSA-70921	Histidine catabolism	0.857850255395733	-0.153325722236674	6	1	0.000439367311072056	2276	8202	144193	AMDHD1
R-HSA-174362	Transport and synthesis of PAPS	0.857850255395733	-0.153325722236674	6	1	0.000439367311072056	2276	8202	1836	SLC26A2
R-HSA-975578	Reactions specific to the complex N-glycan synthesis pathway	0.857850255395733	-0.153325722236674	6	1	0.000439367311072056	2276	8202	4124	MAN2A1
R-HSA-193993	Mineralocorticoid biosynthesis	0.857850255395733	-0.153325722236674	6	1	0.000439367311072056	2276	8202	1081	CGA
R-HSA-2142712	Synthesis of 12-eicosatetraenoic acid derivatives	0.857850255395733	-0.153325722236674	6	1	0.000439367311072056	2276	8202	2879	GPX4
R-HSA-1606341	IRF3 mediated activation of type 1 IFN	0.857850255395733	-0.153325722236674	6	1	0.000439367311072056	2276	8202	23220	DTX4
R-HSA-2142688	Synthesis of 5-eicosatetraenoic acids	0.857850255395733	-0.153325722236674	6	1	0.000439367311072056	2276	8202	2879	GPX4
R-HSA-111957	Cam-PDE 1 activation	0.857850255395733	-0.153325722236674	6	1	0.000439367311072056	2276	8202	805	CALM2
R-HSA-442717	CREB phosphorylation through the activation of CaMKK	0.857850255395733	-0.153325722236674	6	1	0.000439367311072056	2276	8202	805	CALM2
R-HSA-428808	Na+-dependent glucose transporters	0.857850255395733	-0.153325722236674	6	1	0.000439367311072056	2276	8202	91749	KIAA1919
R-HSA-5339717	Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	0.857850255395733	-0.153325722236674	6	1	0.000439367311072056	2276	8202	22943	DKK1
R-HSA-1483249	Inositol phosphate metabolism	0.86068570957546	-0.150025870722985	46	10	0.00439367311072056	2276	8202	805,3636,64768,9807,253430,51477,3633,51447,8867,3613	CALM2,INPPL1,IPPK,IP6K1,IPMK,ISYNA1,INPP5B,IP6K2,SYNJ1,IMPA2
R-HSA-399954	Sema3A PAK dependent Axon repulsion	0.863245840679665	-0.147055760934283	16	3	0.00131810193321617	2276	8202	5058,3320,3326	PAK1,HSP90AA1,HSP90AB1
R-HSA-3928662	EPHB-mediated forward signaling	0.863550747742548	-0.146702613298834	42	9	0.00395430579964851	2276	8202	5058,998,8976,10096,10097,10109,10552,9475,6453	PAK1,CDC42,WASL,ACTR3,ACTR2,ARPC2,ARPC1A,ROCK2,ITSN1
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	0.863550747742548	-0.146702613298834	42	9	0.00395430579964851	2276	8202	59345,2788,11069,51764,10411,5566,2787,2783,5573	GNB4,GNG7,RAPGEF4,GNG13,RAPGEF3,PRKACA,GNG5,GNB2,PRKAR1A
R-HSA-418592	ADP signalling through P2Y purinoceptor 1	0.864178708587777	-0.145975692922984	25	5	0.00219683655536028	2276	8202	51764,2783,59345,2787,2788	GNG13,GNB2,GNB4,GNG5,GNG7
R-HSA-445144	Signal transduction by L1	0.87504403793019	-0.133481064827913	21	4	0.00175746924428822	2276	8202	5058,1460,3688,5604	PAK1,CSNK2B,ITGB1,MAP2K1
R-HSA-397795	G-protein beta:gamma signalling	0.875932742720889	-0.132465968709185	51	11	0.00483304042179262	2276	8202	5170,6464,208,59345,2788,5296,8503,3717,51764,2787,2783	PDPK1,SHC1,AKT2,GNB4,GNG7,PIK3R2,PIK3R3,JAK2,GNG13,GNG5,GNB2
R-HSA-71387	Metabolism of carbohydrates	0.87999133453106	-0.127843218682164	274	68	0.0298769771528998	2276	8202	6517,23511,7360,5837,4191,83440,6382,5566,805,6484,5518,55746,231,3373,2997,2805,9972,1836,5256,2597,7311,25796,5208,5257,5209,9631,8021,10327,5903,8372,2542,10855,6233,226,6483,5528,8086,8704,22934,50515,8480,6652,53371,26229,129401,23165,4927,5105,1468,6548,7314,5631,5261,6576,337876,3161,10678,2990,92579,7316,26035,5226,5091,5230,23636,5224,9818,2582	SLC2A4,NUP188,UGP2,PYGM,MDH2,ADPGK,SDC1,PRKACA,CALM2,ST3GAL4,PPP2R1A,NUP133,AKR1B1,HYAL1,GYS1,GOT1,NUP153,SLC26A2,PHKA2,GAPDH,UBA52,PGLS,PFKFB2,PHKB,PFKFB3,NUP155,NUP214,AKR1A1,RANBP2,HYAL3,SLC37A4,HPSE,RPS27A,ALDOA,ST3GAL2,PPP2R5D,AAAS,B4GALT2,RPIA,CHST11,RAE1,SORD,NUP54,B3GAT3,NUP35,NUP205,NUP88,PCK1,SLC25A10,SLC9A1,UBB,PRPS1,PHKG2,SLC25A1,CHSY3,HMMR,B3GNT2,GUSB,G6PC3,UBC,GLCE,PGD,PC,PGK1,NUP62,PGAM2,NUP58,GALE
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	0.882708372728831	-0.124760401639169	104	24	0.0105448154657293	2276	8202	5170,23112,2931,2475,3164,208,842,1147,84335,23239,572,6464,5296,5781,1027,2932,8503,145957,253260,2065,4343,192669,6199,64223	PDPK1,TNRC6B,GSK3A,MTOR,NR4A1,AKT2,CASP9,CHUK,AKT1S1,PHLPP1,BAD,SHC1,PIK3R2,PTPN11,CDKN1B,GSK3B,PIK3R3,NRG4,RICTOR,ERBB3,MOV10,AGO3,RPS6KB2,MLST8
R-HSA-428157	Sphingolipid metabolism	0.883023671371227	-0.124403270842568	76	17	0.00746924428822496	2276	8202	1455,10825,6609,91012,10087,2629,427,25870,9517,4758,221,55512,55627,10558,56848,224,2760	CSNK1G2,NEU3,SMPD1,CERS5,COL4A3BP,GBA,ASAH1,SUMF2,SPTLC2,NEU1,ALDH3B1,SMPD3,SMPD4,SPTLC1,SPHK2,ALDH3A2,GM2A
R-HSA-451308	Activation of Ca-permeable Kainate Receptor	0.886682948534795	-0.120267803033933	12	2	0.000878734622144112	2276	8202	1742,805	DLG4,CALM2
R-HSA-451306	Ionotropic activity of Kainate Receptors	0.886682948534795	-0.120267803033933	12	2	0.000878734622144112	2276	8202	1742,805	DLG4,CALM2
R-HSA-389359	CD28 dependent Vav1 pathway	0.886682948534795	-0.120267803033933	12	2	0.000878734622144112	2276	8202	5058,998	PAK1,CDC42
R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation	0.890328063703217	-0.116165273273769	17	3	0.00131810193321617	2276	8202	1742,817,10142	DLG4,CAMK2D,AKAP9
R-HSA-174800	Chylomicron-mediated lipid transport	0.890328063703217	-0.116165273273769	17	3	0.00131810193321617	2276	8202	51128,6382,5034	SAR1B,SDC1,P4HB
R-HSA-5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	0.890328063703217	-0.116165273273769	17	3	0.00131810193321617	2276	8202	330,329,7186	BIRC3,BIRC2,TRAF2
R-HSA-198203	PI3K/AKT activation	0.893597805764755	-0.112499486730658	101	23	0.0101054481546573	2276	8202	5170,23112,2931,2475,3164,208,842,1147,84335,23239,572,5296,5781,1027,2932,8503,145957,253260,2065,4343,192669,6199,64223	PDPK1,TNRC6B,GSK3A,MTOR,NR4A1,AKT2,CASP9,CHUK,AKT1S1,PHLPP1,BAD,PIK3R2,PTPN11,CDKN1B,GSK3B,PIK3R3,NRG4,RICTOR,ERBB3,MOV10,AGO3,RPS6KB2,MLST8
R-HSA-2219528	PI3K/AKT Signaling in Cancer	0.894349893235665	-0.111658200919347	85	19	0.00834797891036907	2276	8202	5170,2931,2475,3164,208,842,1147,84335,572,5296,5781,2932,1027,8503,145957,253260,2065,6199,64223	PDPK1,GSK3A,MTOR,NR4A1,AKT2,CASP9,CHUK,AKT1S1,BAD,PIK3R2,PTPN11,GSK3B,CDKN1B,PIK3R3,NRG4,RICTOR,ERBB3,RPS6KB2,MLST8
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	0.894474474482566	-0.111518912513676	48	10	0.00439367311072056	2276	8202	10451,1969,51107,160,1213,163,2044,1942,23385,1175	VAV3,EPHA2,APH1A,AP2A1,CLTC,AP2B1,EPHA5,EFNA1,NCSTN,AP2S1
R-HSA-442720	CREB phosphorylation through the activation of Adenylate Cyclase	0.897324733046161	-0.108337461204038	7	1	0.000439367311072056	2276	8202	5566	PRKACA
R-HSA-447043	Neurofascin interactions	0.897324733046161	-0.108337461204038	7	1	0.000439367311072056	2276	8202	6386	SDCBP
R-HSA-447038	NrCAM interactions	0.897324733046161	-0.108337461204038	7	1	0.000439367311072056	2276	8202	1742	DLG4
R-HSA-83936	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	0.897324733046161	-0.108337461204038	7	1	0.000439367311072056	2276	8202	2030	SLC29A1
R-HSA-75158	TRAIL  signaling	0.897324733046161	-0.108337461204038	7	1	0.000439367311072056	2276	8202	8772	FADD
R-HSA-2660826	Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	0.897324733046161	-0.108337461204038	7	1	0.000439367311072056	2276	8202	6868	ADAM17
R-HSA-2187335	The retinoid cycle in cones (daylight vision)	0.897324733046161	-0.108337461204038	7	1	0.000439367311072056	2276	8202	9249	DHRS3
R-HSA-2660825	Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	0.897324733046161	-0.108337461204038	7	1	0.000439367311072056	2276	8202	6868	ADAM17
R-HSA-427601	Multifunctional anion exchangers	0.897324733046161	-0.108337461204038	7	1	0.000439367311072056	2276	8202	1836	SLC26A2
R-HSA-352230	Amino acid transport across the plasma membrane	0.89772347622691	-0.10789319103319	31	6	0.00263620386643234	2276	8202	6533,6542,6520,23657,81539,124935	SLC6A6,SLC7A2,SLC3A2,SLC7A11,SLC38A1,SLC43A2
R-HSA-975576	N-glycan antennae elongation in the medial/trans-Golgi	0.897736847686824	-0.107878296290336	22	4	0.00175746924428822	2276	8202	6484,6480,8704,4124	ST3GAL4,ST6GAL1,B4GALT2,MAN2A1
R-HSA-4086398	Ca2+ pathway	0.900876043039213	-0.104387607931389	61	13	0.00571177504393673	2276	8202	805,23112,1499,59345,2788,51764,6885,2535,4343,2787,2783,192669,6934	CALM2,TNRC6B,CTNNB1,GNB4,GNG7,GNG13,MAP3K7,FZD2,MOV10,GNG5,GNB2,AGO3,TCF7L2
R-HSA-180292	GAB1 signalosome	0.903922534880312	-0.101011613765767	102	23	0.0101054481546573	2276	8202	5170,23112,2931,2475,3164,208,842,1147,84335,23239,572,5296,5781,1027,2932,8503,145957,253260,2065,4343,192669,6199,64223	PDPK1,TNRC6B,GSK3A,MTOR,NR4A1,AKT2,CASP9,CHUK,AKT1S1,PHLPP1,BAD,PIK3R2,PTPN11,CDKN1B,GSK3B,PIK3R3,NRG4,RICTOR,ERBB3,MOV10,AGO3,RPS6KB2,MLST8
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	0.905430419468219	-0.0993448467224739	86	19	0.00834797891036907	2276	8202	3920,2335,10257,967,7094,9948,5552,3309,22927,813,87,6810,7114,5478,805,10487,226,6814,7414	LAMP2,FN1,ABCC4,CD63,TLN1,WDR1,SRGN,HSPA5,HABP4,CALU,ACTN1,STX4,TMSB4X,PPIA,CALM2,CAP1,ALDOA,STXBP3,VCL
R-HSA-196071	Metabolism of steroid hormones and vitamin D	0.907722195175767	-0.0968168996434393	36	7	0.00307557117750439	2276	8202	231,51170,1081,112812,80765,2232,134429	AKR1B1,HSD17B11,CGA,FDX1L,STARD5,FDXR,STARD4
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	0.907722195175767	-0.0968168996434393	36	7	0.00307557117750439	2276	8202	805,6464,10768,4690,6786,30011,868	CALM2,SHC1,AHCYL1,NCK1,STIM1,SH3KBP1,CBLB
R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle	0.912497656365428	-0.0915697618954434	18	3	0.00131810193321617	2276	8202	4128,6616,5864	MAOA,SNAP25,RAB3A
R-HSA-912631	Regulation of signaling by CBL	0.912497656365428	-0.0915697618954434	18	3	0.00131810193321617	2276	8202	1399,8503,5296	CRKL,PIK3R3,PIK3R2
R-HSA-5635838	Activation of SMO	0.912497656365428	-0.0915697618954434	18	3	0.00131810193321617	2276	8202	84455,1452,2622	EFCAB7,CSNK1A1,GAS8
R-HSA-156584	Cytosolic sulfonation of small molecules	0.912497656365428	-0.0915697618954434	18	3	0.00131810193321617	2276	8202	1836,6820,25830	SLC26A2,SULT2B1,SULT4A1
R-HSA-350054	Notch-HLH transcription pathway	0.912556445912666	-0.0915053369042225	13	2	0.000878734622144112	2276	8202	3516,9794	RBPJ,MAML1
R-HSA-75205	Dissolution of Fibrin Clot	0.912556445912666	-0.0915053369042225	13	2	0.000878734622144112	2276	8202	302,6281	ANXA2,S100A10
R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels	0.912556445912666	-0.0915053369042225	13	2	0.000878734622144112	2276	8202	784,783	CACNB3,CACNB2
R-HSA-74217	Purine salvage	0.912556445912666	-0.0915053369042225	13	2	0.000878734622144112	2276	8202	51292,1716	GMPR2,DGUOK
R-HSA-209822	Glycoprotein hormones	0.912556445912666	-0.0915053369042225	13	2	0.000878734622144112	2276	8202	94027,1081	CGB7,CGA
R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation	0.912556445912666	-0.0915053369042225	13	2	0.000878734622144112	2276	8202	805,10768	CALM2,AHCYL1
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	0.914289008013877	-0.0896085561809985	32	6	0.00263620386643234	2276	8202	2768,51764,2783,59345,2787,2788	GNA12,GNG13,GNB2,GNB4,GNG5,GNG7
R-HSA-400508	Incretin synthesis, secretion, and inactivation	0.916714589576011	-0.0869590988186902	23	4	0.00175746924428822	2276	8202	51764,60559,1499,6934	GNG13,SPCS3,CTNNB1,TCF7L2
R-HSA-194840	Rho GTPase cycle	0.921070164733191	-0.082219062422118	124	28	0.0123022847100176	2276	8202	23092,10451,23433,55789,9886,9322,10928,1894,4983,29127,23365,3633,54509,10144,27237,9901,998,84986,5296,116985,171177,9181,23221,9828,9754,23229,64857,6453	ARHGAP26,VAV3,RHOQ,DEPDC1B,RHOBTB1,TRIP10,RALBP1,ECT2,OPHN1,RACGAP1,ARHGEF12,INPP5B,RHOF,FAM13A,ARHGEF16,SRGAP3,CDC42,ARHGAP19,PIK3R2,ARAP1,RHOV,ARHGEF2,RHOBTB2,ARHGEF17,STARD8,ARHGEF9,PLEKHG2,ITSN1
R-HSA-76009	Platelet Aggregation (Plug Formation)	0.922075106860012	-0.0811285979406776	37	7	0.00307557117750439	2276	8202	5170,5770,10411,2335,6464,7094,11069	PDPK1,PTPN1,RAPGEF3,FN1,SHC1,TLN1,RAPGEF4
R-HSA-418597	G alpha (z) signalling events	0.924896715662062	-0.0780732064477302	46	9	0.00395430579964851	2276	8202	5581,59345,10287,2788,51764,2773,2771,2787,2783	PRKCE,GNB4,RGS19,GNG7,GNG13,GNAI3,GNAI2,GNG5,GNB2
R-HSA-5340588	RNF mutants show enhanced WNT signaling and proliferation	0.925840768135451	-0.0770530157793794	8	1	0.000439367311072056	2276	8202	4040	LRP6
R-HSA-112311	Neurotransmitter Clearance In The Synaptic Cleft	0.925840768135451	-0.0770530157793794	8	1	0.000439367311072056	2276	8202	4128	MAOA
R-HSA-2142670	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	0.925840768135451	-0.0770530157793794	8	1	0.000439367311072056	2276	8202	1545	CYP1B1
R-HSA-5362798	Release of Hh-Np from the secreting cell	0.925840768135451	-0.0770530157793794	8	1	0.000439367311072056	2276	8202	6868	ADAM17
R-HSA-1483148	Synthesis of PG	0.925840768135451	-0.0770530157793794	8	1	0.000439367311072056	2276	8202	201164	PLD6
R-HSA-3000480	Scavenging by Class A Receptors	0.930511466245387	-0.0720208803047316	19	3	0.00131810193321617	2276	8202	811,2512,7184	CALR,FTL,HSP90B1
R-HSA-3928664	Ephrin signaling	0.930511466245387	-0.0720208803047316	19	3	0.00131810193321617	2276	8202	5058,6386,10627	PAK1,SDCBP,MYL12A
R-HSA-5365859	RA biosynthesis pathway	0.93247651028058	-0.0699113178290762	24	4	0.00175746924428822	2276	8202	9249,57665,157506,112724	DHRS3,RDH14,RDH10,RDH13
R-HSA-2162123	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	0.932802533949122	-0.069561746891826	14	2	0.000878734622144112	2276	8202	5743,10728	PTGS2,PTGES3
R-HSA-428540	Activation of Rac	0.932802533949122	-0.069561746891826	14	2	0.000878734622144112	2276	8202	5058,4690	PAK1,NCK1
R-HSA-2024101	CS/DS degradation	0.932802533949122	-0.069561746891826	14	2	0.000878734622144112	2276	8202	3373,8372	HYAL1,HYAL3
R-HSA-170670	Adenylate cyclase inhibitory pathway	0.932802533949122	-0.069561746891826	14	2	0.000878734622144112	2276	8202	2771,2773	GNAI2,GNAI3
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	0.932802533949122	-0.069561746891826	14	2	0.000878734622144112	2276	8202	6237,7094	RRAS,TLN1
R-HSA-997269	Inhibition of adenylate cyclase pathway	0.932802533949122	-0.069561746891826	14	2	0.000878734622144112	2276	8202	2771,2773	GNAI2,GNAI3
R-HSA-918233	TRAF3-dependent IRF activation pathway	0.932802533949122	-0.069561746891826	14	2	0.000878734622144112	2276	8202	80143,64135	SIKE1,IFIH1
R-HSA-5682910	LGI-ADAM interactions	0.932802533949122	-0.069561746891826	14	2	0.000878734622144112	2276	8202	1742,59283	DLG4,CACNG8
R-HSA-114608	Platelet degranulation	0.935412726758068	-0.0667674280975663	81	17	0.00746924428822496	2276	8202	3920,2335,10257,967,7094,9948,5552,3309,22927,813,87,7114,5478,805,10487,226,7414	LAMP2,FN1,ABCC4,CD63,TLN1,WDR1,SRGN,HSPA5,HABP4,CALU,ACTN1,TMSB4X,PPIA,CALM2,CAP1,ALDOA,VCL
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	0.936174656994178	-0.0659532205592841	29	5	0.00219683655536028	2276	8202	6907,1490,204851,1482,7003	TBL1X,CTGF,HIPK1,NKX2-5,TEAD1
R-HSA-1839124	FGFR1 mutant receptor activation	0.936174656994178	-0.0659532205592841	29	5	0.00219683655536028	2276	8202	6777,8805,6774,11052,6772	STAT5B,TRIM24,STAT3,CPSF6,STAT1
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins	0.940129011138666	-0.0617381672432453	43	8	0.00351493848857645	2276	8202	59345,2788,51764,5566,2787,2783,8766,5573	GNB4,GNG7,GNG13,PRKACA,GNG5,GNB2,RAB11A,PRKAR1A
R-HSA-556833	Metabolism of lipids and lipoproteins	0.941055019760784	-0.0607536716471727	628	158	0.0694200351493849	2276	8202	5565,27242,91012,10554,162466,10001,25942,6382,8867,1632,1595,1490,6721,5034,158584,5296,23446,3032,231,1545,9442,6609,10087,25870,857,79143,51170,10555,3638,112812,9282,10891,10005,3636,4594,9871,79993,84803,1718,30849,427,81579,55090,1119,55512,51763,112950,84246,5298,6307,9862,9443,200576,6309,224,2222,3156,23309,3992,9415,85465,2629,2274,3295,8394,9517,55697,55361,8396,8202,51422,2224,51586,47,6907,55627,2101,1717,57107,9374,10858,55500,10162,64900,253558,9453,5566,29079,1040,3422,9441,9110,2820,134429,8503,27063,10558,84188,9572,90390,2760,2879,10802,8904,10484,23597,84274,1081,4597,10025,64850,221,5743,22937,23097,10400,406,5500,22908,9575,56848,2710,51141,10825,54797,10654,51004,10682,3157,4520,9632,2232,10728,3837,6576,6667,55856,7296,1455,9439,60481,5289,1024,7003,56895,50640,4758,51128,5467,3033,201164,80765,51,4802,57678,64801,8310,5130	PRKAB2,TNFRSF21,CERS5,AGPAT1,PHOSPHO1,MED6,SIN3A,SDC1,SYNJ1,ECI1,CYP51A1,CTGF,SREBF2,P4HB,FAAH2,PIK3R2,SLC44A1,HADHB,AKR1B1,CYP1B1,MED27,SMPD1,COL4A3BP,SUMF2,CAV1,MBOAT7,HSD17B11,AGPAT2,INSIG1,FDX1L,MED14,PPARGC1A,ACOT8,INPPL1,MUT,SEC24D,ELOVL7,GPAT3,DHCR24,PIK3R4,ASAH1,PLA2G12A,MED9,CHKA,SMPD3,INPP5K,MED8,MED10,PI4KB,MSMO1,MED24,MED7,PIKFYVE,SC5D,ALDH3A2,FDFT1,HMGCR,SIN3B,FADS1,FADS2,EPT1,GBA,FHL2,HSD17B4,PIP5K1A,SPTLC2,VAC14,PI4K2A,PIP4K2B,NCOA3,PRKAG2,FDPS,MED15,ACLY,TBL1X,SMPD4,ESRRA,DHCR7,PDSS2,PPT2,CYP46A1,ETNK1,LPCAT3,LPIN3,LCLAT1,GGPS1,PRKACA,MED4,CDS1,IDI1,MED26,MTMR4,GPD2,STARD4,PIK3R3,ANKRD1,SPTLC1,FAR1,NR1D1,MED30,GM2A,GPX4,SEC24A,CPNE1,SEC23A,ACOT9,COQ5,CGA,MVD,MED16,ETNPPL,ALDH3B1,PTGS2,SCAP,CDK19,PEMT,ARNTL,PPP1CB,SACM1L,CLOCK,SPHK2,GK,INSIG2,NEU3,MED18,PMVK,COQ6,EBP,HMGCS1,MTF1,SEC24C,FDXR,PTGES3,KPNB1,SLC25A1,SP1,ACOT13,TXNRD1,CSNK1G2,MED23,ELOVL5,PIK3C3,CDK8,TEAD1,AGPAT4,PNPLA8,NEU1,SAR1B,PPARD,HADH,PLD6,STARD5,ACOX1,NFYC,GPAM,ARV1,ACOX3,PCYT1A
R-HSA-163560	Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis	0.945052161894375	-0.0565151552399103	20	3	0.00131810193321617	2276	8202	5500,857,5566	PPP1CB,CAV1,PRKACA
R-HSA-977068	Termination of O-glycan biosynthesis	0.945485615386355	-0.0560566047631261	25	4	0.00175746924428822	2276	8202	6484,4582,6483,6480	ST3GAL4,MUC1,ST3GAL2,ST6GAL1
R-HSA-2142816	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	0.946439549161399	-0.0550481781363659	9	1	0.000439367311072056	2276	8202	1545	CYP1B1
R-HSA-391908	Prostanoid ligand receptors	0.946439549161399	-0.0550481781363659	9	1	0.000439367311072056	2276	8202	5734	PTGER4
R-HSA-1300642	Sperm Motility And Taxes	0.946439549161399	-0.0550481781363659	9	1	0.000439367311072056	2276	8202	57828	CATSPERG
R-HSA-425986	Sodium/Proton exchangers	0.946439549161399	-0.0550481781363659	9	1	0.000439367311072056	2276	8202	6548	SLC9A1
R-HSA-2179392	EGFR Transactivation by Gastrin	0.946439549161399	-0.0550481781363659	9	1	0.000439367311072056	2276	8202	3845	KRAS
R-HSA-390696	Adrenoceptors	0.946439549161399	-0.0550481781363659	9	1	0.000439367311072056	2276	8202	154	ADRB2
R-HSA-1234158	Regulation of gene expression by Hypoxia-inducible Factor	0.946439549161399	-0.0550481781363659	9	1	0.000439367311072056	2276	8202	405	ARNT
R-HSA-139853	Elevation of cytosolic Ca2+ levels	0.946439549161399	-0.0550481781363659	9	1	0.000439367311072056	2276	8202	6786	STIM1
R-HSA-159740	Gamma-carboxylation of protein precursors	0.946439549161399	-0.0550481781363659	9	1	0.000439367311072056	2276	8202	2677	GGCX
R-HSA-420092	Glucagon-type ligand receptors	0.947712552600036	-0.0537040372628682	30	5	0.00219683655536028	2276	8202	51764,2783,59345,2787,2788	GNG13,GNB2,GNB4,GNG5,GNG7
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	0.948550674817622	-0.0528200647636448	15	2	0.000878734622144112	2276	8202	2335,7094	FN1,TLN1
R-HSA-209952	Peptide hormone biosynthesis	0.948550674817622	-0.0528200647636448	15	2	0.000878734622144112	2276	8202	94027,1081	CGB7,CGA
R-HSA-549132	Organic cation/anion/zwitterion transport	0.948550674817622	-0.0528200647636448	15	2	0.000878734622144112	2276	8202	6583,5002	SLC22A4,SLC22A18
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	0.948550674817622	-0.0528200647636448	15	2	0.000878734622144112	2276	8202	2335,7094	FN1,TLN1
R-HSA-3772470	Negative regulation of TCF-dependent signaling by WNT ligand antagonists	0.948550674817622	-0.0528200647636448	15	2	0.000878734622144112	2276	8202	4040,22943	LRP6,DKK1
R-HSA-3238698	WNT ligand biogenesis and trafficking	0.956161175095281	-0.0448287869450704	26	4	0.00175746924428822	2276	8202	80326,9559,51699,55737	WNT10A,VPS26A,VPS29,VPS35
R-HSA-2024096	HS-GAG degradation	0.95672018258424	-0.0442443204776364	21	3	0.00131810193321617	2276	8202	10855,6382,2990	HPSE,SDC1,GUSB
R-HSA-418990	Adherens junctions interactions	0.957325836511845	-0.0436114684544596	31	5	0.00219683655536028	2276	8202	1500,64403,3728,1499,1495	CTNND1,CDH24,JUP,CTNNB1,CTNNA1
R-HSA-5655302	Signaling by FGFR1 in disease	0.959354739969961	-0.0414943663761828	36	6	0.00263620386643234	2276	8202	3845,6777,8805,6774,11052,6772	KRAS,STAT5B,TRIM24,STAT3,CPSF6,STAT1
R-HSA-1482922	Acyl chain remodelling of PI	0.960737079691206	-0.0400544977762386	16	2	0.000878734622144112	2276	8202	81579,79143	PLA2G12A,MBOAT7
R-HSA-399956	CRMPs in Sema3A signaling	0.960737079691206	-0.0400544977762386	16	2	0.000878734622144112	2276	8202	2932,1808	GSK3B,DPYSL2
R-HSA-163615	PKA activation	0.960737079691206	-0.0400544977762386	16	2	0.000878734622144112	2276	8202	5566,5573	PRKACA,PRKAR1A
R-HSA-74259	Purine catabolism	0.961318541729239	-0.039449455914503	10	1	0.000439367311072056	2276	8202	30833	NT5C
R-HSA-419771	Opsins	0.961318541729239	-0.039449455914503	10	1	0.000439367311072056	2276	8202	23596	OPN3
R-HSA-418359	Reduction of cytosolic Ca++ levels	0.961318541729239	-0.039449455914503	10	1	0.000439367311072056	2276	8202	488	ATP2A2
R-HSA-2474795	Diseases associated with visual transduction	0.961318541729239	-0.039449455914503	10	1	0.000439367311072056	2276	8202	222236	NAPEPLD
R-HSA-74749	Signal attenuation	0.961318541729239	-0.039449455914503	10	1	0.000439367311072056	2276	8202	6464	SHC1
R-HSA-418886	Netrin mediated repulsion signals	0.961318541729239	-0.039449455914503	10	1	0.000439367311072056	2276	8202	5781	PTPN11
R-HSA-399997	Acetylcholine regulates insulin secretion	0.961318541729239	-0.039449455914503	10	1	0.000439367311072056	2276	8202	4082	MARCKS
R-HSA-2453864	Retinoid cycle disease events	0.961318541729239	-0.039449455914503	10	1	0.000439367311072056	2276	8202	222236	NAPEPLD
R-HSA-2562578	TRIF-mediated programmed cell death	0.961318541729239	-0.039449455914503	10	1	0.000439367311072056	2276	8202	8772	FADD
R-HSA-418890	Role of second messengers in netrin-1 signaling	0.961318541729239	-0.039449455914503	10	1	0.000439367311072056	2276	8202	5306	PITPNA
R-HSA-75105	Fatty Acyl-CoA Biosynthesis	0.964384875107141	-0.0362648160134288	46	8	0.00351493848857645	2276	8202	60481,9374,23597,79993,47,55856,10005,6576	ELOVL5,PPT2,ACOT9,ELOVL7,ACLY,ACOT13,ACOT8,SLC25A1
R-HSA-5357769	Caspase activation via extrinsic apoptotic signalig pathway	0.964875658186517	-0.0357560375654244	27	4	0.00175746924428822	2276	8202	7186,842,1613,8772	TRAF2,CASP9,DAPK3,FADD
R-HSA-114508	Effects of PIP2 hydrolysis	0.964875658186517	-0.0357560375654244	27	4	0.00175746924428822	2276	8202	5581,8527,221955,26090	PRKCE,DGKD,DAGLB,ABHD12
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	0.964875658186517	-0.0357560375654244	27	4	0.00175746924428822	2276	8202	805,3636,3633,8867	CALM2,INPPL1,INPP5B,SYNJ1
R-HSA-163685	Integration of energy metabolism	0.965723388079697	-0.0348778335185468	107	22	0.00966608084358524	2276	8202	5565,2788,11069,10554,6616,5566,2783,51422,6945,5518,59345,783,47,51764,4082,10411,784,10768,2771,2787,5528,5573	PRKAB2,GNG7,RAPGEF4,AGPAT1,SNAP25,PRKACA,GNB2,PRKAG2,MLX,PPP2R1A,GNB4,CACNB2,ACLY,GNG13,MARCKS,RAPGEF3,CACNB3,AHCYL1,GNAI2,GNG5,PPP2R5D,PRKAR1A
R-HSA-445717	Aquaporin-mediated transport	0.966990050147794	-0.0335670729842672	51	9	0.00395430579964851	2276	8202	59345,2788,282679,51764,5566,8766,2787,2783,5573	GNB4,GNG7,AQP11,GNG13,PRKACA,RAB11A,GNG5,GNB2,PRKAR1A
R-HSA-397014	Muscle contraction	0.969819905222065	-0.0306448894420574	65	12	0.00527240773286467	2276	8202	805,29766,7170,7169,7094,800,7171,4637,302,7414,10627,140465	CALM2,TMOD3,TPM3,TPM2,TLN1,CALD1,TPM4,MYL6,ANXA2,VCL,MYL12A,MYL6B
R-HSA-111931	PKA-mediated phosphorylation of CREB	0.97012494851184	-0.0303304028815733	17	2	0.000878734622144112	2276	8202	5566,5573	PRKACA,PRKAR1A
R-HSA-140534	Ligand-dependent caspase activation	0.97012494851184	-0.0303304028815733	17	2	0.000878734622144112	2276	8202	7186,8772	TRAF2,FADD
R-HSA-164378	PKA activation in glucagon signalling	0.97012494851184	-0.0303304028815733	17	2	0.000878734622144112	2276	8202	5566,5573	PRKACA,PRKAR1A
R-HSA-1482801	Acyl chain remodelling of PS	0.97012494851184	-0.0303304028815733	17	2	0.000878734622144112	2276	8202	81579,10162	PLA2G12A,LPCAT3
R-HSA-264642	Acetylcholine Neurotransmitter Release Cycle	0.97012494851184	-0.0303304028815733	17	2	0.000878734622144112	2276	8202	6616,5864	SNAP25,RAB3A
R-HSA-933541	TRAF6 mediated IRF7 activation	0.971872118991702	-0.0285310480004603	33	5	0.00219683655536028	2276	8202	3660,80143,64135,170506,7186	IRF2,SIKE1,IFIH1,DHX36,TRAF2
R-HSA-2022854	Keratan sulfate biosynthesis	0.971954776601773	-0.0284460017339351	28	4	0.00175746924428822	2276	8202	6483,6484,10678,8704	ST3GAL2,ST3GAL4,B3GNT2,B4GALT2
R-HSA-376172	DSCAM interactions	0.97206548985545	-0.0283321003968889	11	1	0.000439367311072056	2276	8202	5058	PAK1
R-HSA-375281	Hormone ligand-binding receptors	0.97206548985545	-0.0283321003968889	11	1	0.000439367311072056	2276	8202	1081	CGA
R-HSA-193048	Androgen biosynthesis	0.97206548985545	-0.0283321003968889	11	1	0.000439367311072056	2276	8202	1081	CGA
R-HSA-5655291	Signaling by FGFR4 in disease	0.97206548985545	-0.0283321003968889	11	1	0.000439367311072056	2276	8202	3845	KRAS
R-HSA-159854	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	0.97206548985545	-0.0283321003968889	11	1	0.000439367311072056	2276	8202	2677	GGCX
R-HSA-425397	Transport of vitamins, nucleosides, and related molecules	0.972593536872043	-0.0277890262411494	38	6	0.00263620386643234	2276	8202	55343,8884,2030,10559,84912,9197	SLC35C1,SLC5A6,SLC29A1,SLC35A1,SLC35B4,SLC33A1
R-HSA-1482839	Acyl chain remodelling of PE	0.97343115337318	-0.0269281773967713	23	3	0.00131810193321617	2276	8202	81579,10162,50640	PLA2G12A,LPCAT3,PNPLA8
R-HSA-5654719	SHC-mediated cascade:FGFR4	0.97343115337318	-0.0269281773967713	23	3	0.00131810193321617	2276	8202	3845,6464,5781	KRAS,SHC1,PTPN11
R-HSA-373760	L1CAM interactions	0.975852951326669	-0.0244433685444136	97	19	0.00834797891036907	2276	8202	6323,5058,3312,5604,1742,1460,9252,214,24137,6196,1808,160,1785,3688,163,6386,1175,8650,6709	SCN1A,PAK1,HSPA8,MAP2K1,DLG4,CSNK2B,RPS6KA5,ALCAM,KIF4A,RPS6KA2,DPYSL2,AP2A1,DNM2,ITGB1,AP2B1,SDCBP,AP2S1,NUMB,SPTAN1
R-HSA-422356	Regulation of insulin secretion	0.976981686839111	-0.0232873713943435	80	15	0.00659050966608084	2276	8202	783,59345,2788,11069,51764,4082,6616,10411,784,10768,2771,5566,2787,2783,5573	CACNB2,GNB4,GNG7,RAPGEF4,GNG13,MARCKS,SNAP25,RAPGEF3,CACNB3,AHCYL1,GNAI2,PRKACA,GNG5,GNB2,PRKAR1A
R-HSA-1489509	DAG and IP3 signaling	0.977275263727859	-0.0229869227856066	34	5	0.00219683655536028	2276	8202	5581,805,10768,5566,5573	PRKCE,CALM2,AHCYL1,PRKACA,PRKAR1A
R-HSA-5654704	SHC-mediated cascade:FGFR3	0.977328360013756	-0.0229325933192484	18	2	0.000878734622144112	2276	8202	3845,6464	KRAS,SHC1
R-HSA-209776	Amine-derived hormones	0.977328360013756	-0.0229325933192484	18	2	0.000878734622144112	2276	8202	1081,1734	CGA,DIO2
R-HSA-181429	Serotonin Neurotransmitter Release Cycle	0.977328360013756	-0.0229325933192484	18	2	0.000878734622144112	2276	8202	6616,5864	SNAP25,RAB3A
R-HSA-156580	Phase II conjugation	0.978933489713585	-0.0212915757220769	98	19	0.00834797891036907	2276	8202	2954,4837,7360,2729,4259,7358,25830,4548,2937,4552,10327,27430,373156,119391,79017,9,1836,55748,6820	GSTZ1,NNMT,UGP2,GCLC,MGST3,UGDH,SULT4A1,MTR,GSS,MTRR,AKR1A1,MAT2B,GSTK1,GSTO2,GGCT,NAT1,SLC26A2,CNDP2,SULT2B1
R-HSA-977606	Regulation of Complement cascade	0.979281816662239	-0.0209358161166911	24	3	0.00131810193321617	2276	8202	966,1604,725	CD59,CD55,C4BPB
R-HSA-210500	Glutamate Neurotransmitter Release Cycle	0.979281816662239	-0.0209358161166911	24	3	0.00131810193321617	2276	8202	2744,6616,5864	GLS,SNAP25,RAB3A
R-HSA-936837	Ion transport by P-type ATPases	0.979384421904181	-0.0208310455947764	49	8	0.00351493848857645	2276	8202	476,488,10396,148229,483,57205,51076,374868	ATP1A1,ATP2A2,ATP8A1,ATP8B3,ATP1B3,ATP10D,CUTC,ATP9B
R-HSA-1475029	Reversible hydration of carbon dioxide	0.979827539086857	-0.0203787033275241	12	1	0.000439367311072056	2276	8202	11238	CA5B
R-HSA-3656237	Defective EXT2 causes exostoses 2	0.979827539086857	-0.0203787033275241	12	1	0.000439367311072056	2276	8202	6382	SDC1
R-HSA-390666	Serotonin receptors	0.979827539086857	-0.0203787033275241	12	1	0.000439367311072056	2276	8202	3361	HTR5A
R-HSA-210990	PECAM1 interactions	0.979827539086857	-0.0203787033275241	12	1	0.000439367311072056	2276	8202	5781	PTPN11
R-HSA-1296346	Tandem pore domain potassium channels	0.979827539086857	-0.0203787033275241	12	1	0.000439367311072056	2276	8202	3775	KCNK1
R-HSA-3656253	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	0.979827539086857	-0.0203787033275241	12	1	0.000439367311072056	2276	8202	6382	SDC1
R-HSA-432047	Passive transport by Aquaporins	0.979827539086857	-0.0203787033275241	12	1	0.000439367311072056	2276	8202	282679	AQP11
R-HSA-114604	GPVI-mediated activation cascade	0.980539817153033	-0.0196520251411598	54	9	0.00395430579964851	2276	8202	5170,10451,6464,998,208,5296,5781,8503,3717	PDPK1,VAV3,SHC1,CDC42,AKT2,PIK3R2,PTPN11,PIK3R3,JAK2
R-HSA-2672351	Stimuli-sensing channels	0.981656168275964	-0.01851416607747	99	19	0.00834797891036907	2276	8202	1183,1182,7311,1831,5894,196527,219931,23327,7316,6233,23678,6717,1185,6446,7314,150159,53373,57578,26133	CLCN4,CLCN3,UBA52,TSC22D3,RAF1,ANO6,TPCN2,NEDD4L,UBC,RPS27A,SGK3,SRI,CLCN6,SGK1,UBB,SLC9B1,TPCN1,UNC79,TRPC4AP
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	0.981747571671631	-0.0184210589962587	40	6	0.00263620386643234	2276	8202	10525,811,2512,10808,3320,7184	HYOU1,CALR,FTL,HSPH1,HSP90AA1,HSP90B1
R-HSA-2871809	FCERI mediated Ca+2 mobilization	0.982289910069116	-0.0178687900947622	30	4	0.00175746924428822	2276	8202	805,10451,6464,10768	CALM2,VAV3,SHC1,AHCYL1
R-HSA-416700	Other semaphorin interactions	0.982836229863559	-0.017312775091536	19	2	0.000878734622144112	2276	8202	57556,3688	SEMA6A,ITGB1
R-HSA-418360	Platelet calcium homeostasis	0.982836229863559	-0.017312775091536	19	2	0.000878734622144112	2276	8202	488,6786	ATP2A2,STIM1
R-HSA-997272	Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits	0.983890389584808	-0.0162407808328768	25	3	0.00131810193321617	2276	8202	2787,2783,2788	GNG5,GNB2,GNG7
R-HSA-1296059	G protein gated Potassium channels	0.983890389584808	-0.0162407808328768	25	3	0.00131810193321617	2276	8202	2787,2783,2788	GNG5,GNB2,GNG7
R-HSA-1482788	Acyl chain remodelling of PC	0.983890389584808	-0.0162407808328768	25	3	0.00131810193321617	2276	8202	81579,10162,50640	PLA2G12A,LPCAT3,PNPLA8
R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	0.983890389584808	-0.0162407808328768	25	3	0.00131810193321617	2276	8202	60481,9374,79993	ELOVL5,PPT2,ELOVL7
R-HSA-1296041	Activation of G protein gated Potassium channels	0.983890389584808	-0.0162407808328768	25	3	0.00131810193321617	2276	8202	2787,2783,2788	GNG5,GNB2,GNG7
R-HSA-418346	Platelet homeostasis	0.984131240770317	-0.0159960160569245	78	14	0.00615114235500879	2276	8202	5529,488,5518,6786,59345,2788,5781,5527,8654,51764,5526,5528,2783,2787	PPP2R5E,ATP2A2,PPP2R1A,STIM1,GNB4,GNG7,PTPN11,PPP2R5C,PDE5A,GNG13,PPP2R5B,PPP2R5D,GNB2,GNG5
R-HSA-167021	PLC-gamma1 signalling	0.985299725192189	-0.0148093945615024	36	5	0.00219683655536028	2276	8202	805,5581,10768,5566,5573	CALM2,PRKCE,AHCYL1,PRKACA,PRKAR1A
R-HSA-212718	EGFR interacts with phospholipase C-gamma	0.985299725192189	-0.0148093945615024	36	5	0.00219683655536028	2276	8202	805,5581,10768,5566,5573	CALM2,PRKCE,AHCYL1,PRKACA,PRKAR1A
R-HSA-1502540	Signaling by Activin	0.985433463519662	-0.0146736701230603	13	1	0.000439367311072056	2276	8202	10272	FSTL3
R-HSA-1679131	Trafficking and processing of endosomal TLR	0.985433463519662	-0.0146736701230603	13	1	0.000439367311072056	2276	8202	7184	HSP90B1
R-HSA-400511	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	0.985433463519662	-0.0146736701230603	13	1	0.000439367311072056	2276	8202	60559	SPCS3
R-HSA-977441	GABA A receptor activation	0.985433463519662	-0.0146736701230603	13	1	0.000439367311072056	2276	8202	23229	ARHGEF9
R-HSA-75892	Platelet Adhesion to exposed collagen	0.985433463519662	-0.0146736701230603	13	1	0.000439367311072056	2276	8202	3688	ITGB1
R-HSA-1663150	The activation of arylsulfatases	0.985433463519662	-0.0146736701230603	13	1	0.000439367311072056	2276	8202	25870	SUMF2
R-HSA-2029485	Role of phospholipids in phagocytosis	0.98750724364662	-0.0125714468954142	26	3	0.00131810193321617	2276	8202	5581,10768,5296	PRKCE,AHCYL1,PIK3R2
R-HSA-5654699	SHC-mediated cascade:FGFR2	0.98750724364662	-0.0125714468954142	26	3	0.00131810193321617	2276	8202	3845,6464,5781	KRAS,SHC1,PTPN11
R-HSA-111885	Opioid Signalling	0.987508127413272	-0.0125705519488079	84	15	0.00659050966608084	2276	8202	805,5141,5518,59345,2788,51764,5144,10768,2771,2773,5566,2787,2783,5528,5573	CALM2,PDE4A,PPP2R1A,GNB4,GNG7,GNG13,PDE4D,AHCYL1,GNAI2,GNAI3,PRKACA,GNG5,GNB2,PPP2R5D,PRKAR1A
R-HSA-3000171	Non-integrin membrane-ECM interactions	0.987980914931674	-0.0120918982916173	42	6	0.00263620386643234	2276	8202	87,6382,1605,3688,51399,3914	ACTN1,SDC1,DAG1,ITGB1,TRAPPC4,LAMB3
R-HSA-1251932	PLCG1 events in ERBB2 signaling	0.988226220890776	-0.0118436389306273	37	5	0.00219683655536028	2276	8202	805,5581,10768,5566,5573	CALM2,PRKCE,AHCYL1,PRKACA,PRKAR1A
R-HSA-202433	Generation of second messenger molecules	0.988944387300146	-0.0111171801839936	32	4	0.00175746924428822	2276	8202	3122,5058,7408,4690	HLA-DRA,PAK1,VASP,NCK1
R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	0.989481996546346	-0.0105737086008987	14	1	0.000439367311072056	2276	8202	10858	CYP46A1
R-HSA-2022870	Chondroitin sulfate biosynthesis	0.990225436202533	-0.00982264844035559	21	2	0.000878734622144112	2276	8202	337876,50515	CHSY3,CHST11
R-HSA-5654688	SHC-mediated cascade:FGFR1	0.990225436202533	-0.00982264844035559	21	2	0.000878734622144112	2276	8202	3845,6464	KRAS,SHC1
R-HSA-156588	Glucuronidation	0.990225436202533	-0.00982264844035559	21	2	0.000878734622144112	2276	8202	7360,7358	UGP2,UGDH
R-HSA-202733	Cell surface interactions at the vascular wall	0.990271686853054	-0.00977594233814447	99	18	0.00790861159929701	2276	8202	6520,2335,4973,682,3845,50848,857,5478,1525,23657,6464,2886,5296,5781,3688,6566,483,284	SLC3A2,FN1,OLR1,BSG,KRAS,F11R,CAV1,PPIA,CXADR,SLC7A11,SHC1,GRB7,PIK3R2,PTPN11,ITGB1,SLC16A1,ATP1B3,ANGPT1
R-HSA-192105	Synthesis of bile acids and bile salts	0.990336191820486	-0.00971080580289264	27	3	0.00131810193321617	2276	8202	3295,10858,10005	HSD17B4,CYP46A1,ACOT8
R-HSA-446728	Cell junction organization	0.990908997390302	-0.00913257794003602	86	15	0.00659050966608084	2276	8202	29780,64403,7408,3728,1499,1495,3688,5584,1500,50848,87,5339,1365,6251,3914	PARVB,CDH24,VASP,JUP,CTNNB1,CTNNA1,ITGB1,PRKCI,CTNND1,F11R,ACTN1,PLEC,CLDN3,RSU1,LAMB3
R-HSA-1638074	Keratan sulfate/keratin metabolism	0.991299182927188	-0.0087388901873573	33	4	0.00175746924428822	2276	8202	6483,6484,10678,8704	ST3GAL2,ST3GAL4,B3GNT2,B4GALT2
R-HSA-391903	Eicosanoid ligand-binding receptors	0.992405662387649	-0.00762332142940931	15	1	0.000439367311072056	2276	8202	5734	PTGER4
R-HSA-977444	GABA B receptor activation	0.992505664409657	-0.00752255922331772	39	5	0.00219683655536028	2276	8202	2771,2773,2787,2783,2788	GNAI2,GNAI3,GNG5,GNB2,GNG7
R-HSA-991365	Activation of GABAB receptors	0.992505664409657	-0.00752255922331772	39	5	0.00219683655536028	2276	8202	2771,2773,2787,2783,2788	GNAI2,GNAI3,GNG5,GNB2,GNG7
R-HSA-111933	Calmodulin induced events	0.992541961659851	-0.00748598856403284	28	3	0.00131810193321617	2276	8202	805,5566,5573	CALM2,PRKACA,PRKAR1A
R-HSA-111997	CaM pathway	0.992541961659851	-0.00748598856403284	28	3	0.00131810193321617	2276	8202	805,5566,5573	CALM2,PRKACA,PRKAR1A
R-HSA-2453902	The canonical retinoid cycle in rods (twilight vision)	0.992644645726319	-0.00738253827258168	22	2	0.000878734622144112	2276	8202	222236,157506	NAPEPLD,RDH10
R-HSA-390522	Striated Muscle Contraction	0.993169038832663	-0.00685439897873929	34	4	0.00175746924428822	2276	8202	29766,7170,7169,7171	TMOD3,TPM3,TPM2,TPM4
R-HSA-1226099	Signaling by FGFR in disease	0.993699865449156	-0.00632006414871674	45	6	0.00263620386643234	2276	8202	3845,6777,8805,6774,11052,6772	KRAS,STAT5B,TRIM24,STAT3,CPSF6,STAT1
R-HSA-389948	PD-1 signaling	0.994474502147189	-0.00554081988336869	23	2	0.000878734622144112	2276	8202	3122,5781	HLA-DRA,PTPN11
R-HSA-3000157	Laminin interactions	0.994474502147189	-0.00554081988336869	23	2	0.000878734622144112	2276	8202	3688,3914	ITGB1,LAMB3
R-HSA-212676	Dopamine Neurotransmitter Release Cycle	0.994474502147189	-0.00554081988336869	23	2	0.000878734622144112	2276	8202	6616,5864	SNAP25,RAB3A
R-HSA-2022377	Metabolism of Angiotensinogen to Angiotensins	0.994516901230545	-0.00549818613111598	16	1	0.000439367311072056	2276	8202	10159	ATP6AP2
R-HSA-1433559	Regulation of KIT signaling	0.994516901230545	-0.00549818613111598	16	1	0.000439367311072056	2276	8202	8651	SOCS1
R-HSA-112043	PLC beta mediated events	0.99494416580015	-0.00506865817175558	46	6	0.00263620386643234	2276	8202	805,10768,2771,2773,5566,5573	CALM2,AHCYL1,GNAI2,GNAI3,PRKACA,PRKAR1A
R-HSA-111996	Ca-dependent events	0.995586510031148	-0.00442325816753172	30	3	0.00131810193321617	2276	8202	805,5566,5573	CALM2,PRKACA,PRKAR1A
R-HSA-157858	Gap junction trafficking and regulation	0.995586510031148	-0.00442325816753172	30	3	0.00131810193321617	2276	8202	7082,1213,1785	TJP1,CLTC,DNM2
R-HSA-174824	Lipoprotein metabolism	0.995586510031148	-0.00442325816753172	30	3	0.00131810193321617	2276	8202	51128,6382,5034	SAR1B,SDC1,P4HB
R-HSA-420029	Tight junction interactions	0.995586510031148	-0.00442325816753172	30	3	0.00131810193321617	2276	8202	50848,1365,5584	F11R,CLDN3,PRKCI
R-HSA-5683826	Surfactant metabolism	0.995586510031148	-0.00442325816753172	30	3	0.00131810193321617	2276	8202	21,7270,29080	ABCA3,TTF1,CCDC59
R-HSA-1500931	Cell-Cell communication	0.995654899312259	-0.00435456807218018	131	24	0.0105448154657293	2276	8202	5058,8935,3728,4690,1495,50848,87,5339,6251,3914,29780,64403,7408,23607,1499,8976,5296,3688,5584,5781,2185,1500,1365,6709	PAK1,SKAP2,JUP,NCK1,CTNNA1,F11R,ACTN1,PLEC,RSU1,LAMB3,PARVB,CDH24,VASP,CD2AP,CTNNB1,WASL,PIK3R2,ITGB1,PRKCI,PTPN11,PTK2B,CTNND1,CLDN3,SPTAN1
R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	0.995855655363408	-0.00415295623401228	24	2	0.000878734622144112	2276	8202	3295,10005	HSD17B4,ACOT8
R-HSA-112040	G-protein mediated events	0.995951659267444	-0.00405655744743846	47	6	0.00263620386643234	2276	8202	805,10768,2771,2773,5566,5573	CALM2,AHCYL1,GNAI2,GNAI3,PRKACA,PRKAR1A
R-HSA-422085	Synthesis, secretion, and deacylation of Ghrelin	0.996041398297378	-0.0039664577057202	17	1	0.000439367311072056	2276	8202	60559	SPCS3
R-HSA-1482925	Acyl chain remodelling of PG	0.996041398297378	-0.0039664577057202	17	1	0.000439367311072056	2276	8202	81579	PLA2G12A
R-HSA-373752	Netrin-1 signaling	0.996260727422757	-0.00374628113367056	42	5	0.00219683655536028	2276	8202	5306,998,4690,8976,5781	PITPNA,CDC42,NCK1,WASL,PTPN11
R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides	0.996269289614008	-0.00373768684281572	96	16	0.0070298769771529	2276	8202	6520,81539,6522,6542,9990,26503,6574,6533,23657,1497,1468,9497,6548,1836,124935,57468	SLC3A2,SLC38A1,SLC4A2,SLC7A2,SLC12A6,SLC17A5,SLC20A1,SLC6A6,SLC7A11,CTNS,SLC25A10,SLC4A7,SLC9A1,SLC26A2,SLC43A2,SLC12A5
R-HSA-1296065	Inwardly rectifying K+ channels	0.996614890600229	-0.00339085184546221	31	3	0.00131810193321617	2276	8202	2787,2783,2788	GNG5,GNB2,GNG7
R-HSA-2129379	Molecules associated with elastic fibres	0.996614890600229	-0.00339085184546221	31	3	0.00131810193321617	2276	8202	4052,4236,3688	LTBP1,MFAP1,ITGB1
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	0.997142165239651	-0.00286192616700949	18	1	0.000439367311072056	2276	8202	3122	HLA-DRA
R-HSA-418457	cGMP effects	0.997142165239651	-0.00286192616700949	18	1	0.000439367311072056	2276	8202	8654	PDE5A
R-HSA-913709	O-linked glycosylation of mucins	0.997144238851552	-0.002859846614247	64	9	0.00395430579964851	2276	8202	6484,56913,4582,10678,6480,29071,63917,6483,55568	ST3GAL4,C1GALT1,MUC1,B3GNT2,ST6GAL1,C1GALT1C1,GALNT11,ST3GAL2,GALNT10
R-HSA-1650814	Collagen biosynthesis and modifying enzymes	0.997144238851552	-0.002859846614247	64	9	0.00395430579964851	2276	8202	5479,7092,5034,79709,1294,871,8985,1288,1303	PPIB,TLL1,P4HB,COLGALT1,COL7A1,SERPINH1,PLOD3,COL4A6,COL12A1
R-HSA-186712	Regulation of beta-cell development	0.99740839094519	-0.00259497308698437	32	3	0.00131810193321617	2276	8202	3280,3516,208	HES1,RBPJ,AKT2
R-HSA-1971475	A tetrasaccharide linker sequence is required for GAG synthesis	0.997678519078646	-0.00232417973582816	26	2	0.000878734622144112	2276	8202	6382,26229	SDC1,B3GAT3
R-HSA-422475	Axon guidance	0.997903487307375	-0.00209871345184506	516	116	0.0509666080843585	2276	8202	161742,10142,200734,1848,4763,5894,10096,5604,4627,1460,5526,4628,57556,805,27,5707,5696,6196,5687,6464,10487,998,5518,1808,28956,1785,11221,163,4637,10097,4233,7414,6453,7311,4690,51107,3326,3312,5695,1742,214,10627,5529,817,5719,1969,6233,5714,5709,8976,1213,3688,4296,2932,5527,5690,784,23122,5705,9861,5700,1175,5528,23385,284,8650,6323,5689,5693,673,2335,7094,5245,5713,9252,5715,9491,1847,7408,783,5781,3717,145957,5717,3320,6386,2065,7314,9475,5686,5694,1843,6709,5058,10451,5692,6237,5702,5682,3845,23365,2044,5710,10552,4140,5691,7316,9901,24137,369,160,84078,5306,1942,10109,10197	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,ACTR3,MAP2K1,MYH9,CSNK2B,PPP2R5B,MYH10,SEMA6A,CALM2,ABL2,PSMD1,PSMB8,RPS6KA2,PSMA6,SHC1,CAP1,CDC42,PPP2R1A,DPYSL2,LAMTOR2,DNM2,DUSP10,AP2B1,MYL6,ACTR2,MET,VCL,ITSN1,UBA52,NCK1,APH1A,HSP90AB1,HSPA8,PSMB7,DLG4,ALCAM,MYL12A,PPP2R5E,CAMK2D,PSMD13,EPHA2,RPS27A,PSMD8,PSMD3,WASL,CLTC,ITGB1,MAP3K11,GSK3B,PPP2R5C,PSMB2,CACNB3,CLASP2,PSMC5,PSMD6,PSMC1,AP2S1,PPP2R5D,NCSTN,ANGPT1,NUMB,SCN1A,PSMB1,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,RPS6KA5,PSMD9,PSMF1,DUSP5,VASP,CACNB2,PTPN11,JAK2,NRG4,PSMD11,HSP90AA1,SDCBP,ERBB3,UBB,ROCK2,PSMA5,PSMB6,DUSP1,SPTAN1,PAK1,VAV3,PSMB4,RRAS,PSMC3,PSMA1,KRAS,ARHGEF12,EPHA5,PSMD4,ARPC1A,MARK3,PSMB3,UBC,SRGAP3,KIF4A,ARAF,AP2A1,KBTBD7,PITPNA,EFNA1,ARPC2,PSME3
R-HSA-3560801	Defective B3GAT3 causes JDSSDHD	0.997936939422075	-0.00206519161888126	19	1	0.000439367311072056	2276	8202	6382	SDC1
R-HSA-3560783	Defective B4GALT7 causes EDS, progeroid type	0.997936939422075	-0.00206519161888126	19	1	0.000439367311072056	2276	8202	6382	SDC1
R-HSA-4420332	Defective B3GALT6 causes EDSP2 and SEMDJL1	0.997936939422075	-0.00206519161888126	19	1	0.000439367311072056	2276	8202	6382	SDC1
R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters	0.997936939422075	-0.00206519161888126	19	1	0.000439367311072056	2276	8202	6533	SLC6A6
R-HSA-112310	Neurotransmitter Release Cycle	0.99794727476421	-0.00205483496385942	50	6	0.00263620386643234	2276	8202	4128,2744,80331,6616,3312,5864	MAOA,GLS,DNAJC5,SNAP25,HSPA8,RAB3A
R-HSA-421270	Cell-cell junction organization	0.998146991295813	-0.00185472764862344	61	8	0.00351493848857645	2276	8202	64403,3728,1499,1495,5584,50848,1500,1365	CDH24,JUP,CTNNB1,CTNNA1,PRKCI,F11R,CTNND1,CLDN3
R-HSA-2980736	Peptide hormone metabolism	0.998199221679535	-0.00180240167089992	86	13	0.00571177504393673	2276	8202	94027,64924,1499,1081,56605,55676,60412,51764,55770,60559,1363,6934,10159	CGB7,SLC30A5,CTNNB1,CGA,ERO1B,SLC30A6,EXOC4,GNG13,EXOC2,SPCS3,CPE,TCF7L2,ATP6AP2
R-HSA-1793185	Chondroitin sulfate/dermatan sulfate metabolism	0.998369487353551	-0.00163184337890844	51	6	0.00263620386643234	2276	8202	337876,3373,50515,8372,6382,26229	CHSY3,HYAL1,CHST11,HYAL3,SDC1,B3GAT3
R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.998414675209268	-0.00158658274776732	101	16	0.0070298769771529	2276	8202	1317,6533,6517,64924,29988,5002,64116,23446,55676,6566,154091,4891,91749,7779,6583,27173	SLC31A1,SLC6A6,SLC2A4,SLC30A5,SLC2A8,SLC22A18,SLC39A8,SLC44A1,SLC30A6,SLC16A1,SLC2A12,SLC11A2,KIAA1919,SLC30A1,SLC22A4,SLC39A1
R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade	0.99848869300677	-0.00151245016958297	34	3	0.00131810193321617	2276	8202	805,4836,388531	CALM2,NMT1,RGS9BP
R-HSA-210745	Regulation of gene expression in beta cells	0.998510754150793	-0.00149035587801439	20	1	0.000439367311072056	2276	8202	208	AKT2
R-HSA-76002	Platelet activation, signaling and aggregation	0.998555986552489	-0.00144505703969091	230	45	0.0197715289982425	2276	8202	2335,967,7094,5894,5552,22927,8527,2783,5478,5581,805,5770,6464,998,10487,5296,5781,8503,3717,51764,10411,2771,7414,2787,3920,5170,10451,10257,208,9948,2788,3309,11069,813,87,6810,2773,7114,2768,221955,26090,59345,226,6814,7534	FN1,CD63,TLN1,RAF1,SRGN,HABP4,DGKD,GNB2,PPIA,PRKCE,CALM2,PTPN1,SHC1,CDC42,CAP1,PIK3R2,PTPN11,PIK3R3,JAK2,GNG13,RAPGEF3,GNAI2,VCL,GNG5,LAMP2,PDPK1,VAV3,ABCC4,AKT2,WDR1,GNG7,HSPA5,RAPGEF4,CALU,ACTN1,STX4,GNAI3,TMSB4X,GNA12,DAGLB,ABHD12,GNB4,ALDOA,STXBP3,YWHAZ
R-HSA-5654227	Phospholipase C-mediated cascade; FGFR3	0.998562447048975	-0.00143858722159958	46	5	0.00219683655536028	2276	8202	805,5581,10768,5566,5573	CALM2,PRKCE,AHCYL1,PRKACA,PRKAR1A
R-HSA-425407	SLC-mediated transmembrane transport	0.99858847911986	-0.00141251801416494	264	53	0.023286467486819	2276	8202	6517,23511,64924,29988,8480,53371,9197,6522,8884,2030,6542,9990,6574,27173,23165,129401,1317,4927,23657,55746,5002,23446,55676,84912,1468,6548,154091,9972,1836,57468,10559,6520,81539,64116,55343,4891,9631,26503,92579,8021,5903,6533,1497,2542,6566,9497,23636,91749,7779,124935,6583,9818,8086	SLC2A4,NUP188,SLC30A5,SLC2A8,RAE1,NUP54,SLC33A1,SLC4A2,SLC5A6,SLC29A1,SLC7A2,SLC12A6,SLC20A1,SLC39A1,NUP205,NUP35,SLC31A1,NUP88,SLC7A11,NUP133,SLC22A18,SLC44A1,SLC30A6,SLC35B4,SLC25A10,SLC9A1,SLC2A12,NUP153,SLC26A2,SLC12A5,SLC35A1,SLC3A2,SLC38A1,SLC39A8,SLC35C1,SLC11A2,NUP155,SLC17A5,G6PC3,NUP214,RANBP2,SLC6A6,CTNS,SLC37A4,SLC16A1,SLC4A7,NUP62,KIAA1919,SLC30A1,SLC43A2,SLC22A4,NUP58,AAAS
R-HSA-190828	Gap junction trafficking	0.998706208616757	-0.00129462905390625	28	2	0.000878734622144112	2276	8202	1213,1785	CLTC,DNM2
R-HSA-2514856	The phototransduction cascade	0.998848626913608	-0.00115203642560046	35	3	0.00131810193321617	2276	8202	805,4836,388531	CALM2,NMT1,RGS9BP
R-HSA-194068	Bile acid and bile salt metabolism	0.998848626913608	-0.00115203642560046	35	3	0.00131810193321617	2276	8202	3295,10858,10005	HSD17B4,CYP46A1,ACOT8
R-HSA-202427	Phosphorylation of CD3 and TCR zeta chains	0.998925020076006	-0.00107555812932227	21	1	0.000439367311072056	2276	8202	3122	HLA-DRA
R-HSA-1266738	Developmental Biology	0.998952035625801	-0.00104851387280049	710	163	0.0716168717047452	2276	8202	4763,10001,4628,805,27,5707,5696,6196,1499,6721,998,1808,1785,11221,163,10097,6453,7311,4690,51107,2649,208,1019,9442,3312,100271849,5432,5719,1969,6233,5714,1213,3688,4296,5690,2932,5527,9282,5705,10891,5700,5528,284,8650,6323,5689,5693,2335,5440,7094,1495,5245,5713,4205,5715,1847,55090,59283,7408,112950,84246,783,5105,9862,6386,9443,9475,5431,5686,5058,6237,57167,5702,5682,3845,10552,5691,24137,8202,9043,369,160,51586,5434,5306,1942,6907,10109,6938,200734,10142,161742,6517,1848,5894,10096,5604,4627,1460,5526,57556,29079,5687,6464,10487,9441,5518,28956,4637,4233,5970,7414,90390,3326,5695,1742,10025,4209,214,10627,663,817,5529,23097,8976,5709,23122,784,9861,1175,23385,673,6929,54797,9252,9491,5781,3717,5717,145957,3320,2065,7314,6774,1843,6709,5694,10451,3280,9439,5692,1024,23365,2044,5710,4140,9901,5430,7316,5608,84078,3516,10197	NF1,MED6,MYH10,CALM2,ABL2,PSMD1,PSMB8,RPS6KA2,CTNNB1,SREBF2,CDC42,DPYSL2,DNM2,DUSP10,AP2B1,ACTR2,ITSN1,UBA52,NCK1,APH1A,NR6A1,AKT2,CDK4,MED27,HSPA8,MEF2B,POLR2C,PSMD13,EPHA2,RPS27A,PSMD8,CLTC,ITGB1,MAP3K11,PSMB2,GSK3B,PPP2R5C,MED14,PSMC5,PPARGC1A,PSMC1,PPP2R5D,ANGPT1,NUMB,SCN1A,PSMB1,PSMB5,FN1,POLR2K,TLN1,CTNNA1,PHB,PSMD7,MEF2A,PSMD9,DUSP5,MED9,CACNG8,VASP,MED8,MED10,CACNB2,PCK1,MED24,SDCBP,MED7,ROCK2,POLR2B,PSMA5,PAK1,RRAS,SALL4,PSMC3,PSMA1,KRAS,ARPC1A,PSMB3,KIF4A,NCOA3,SPAG9,ARAF,AP2A1,MED15,POLR2E,PITPNA,EFNA1,TBL1X,ARPC2,TCF12,SPRED2,AKAP9,SPRED1,SLC2A4,DUSP6,RAF1,ACTR3,MAP2K1,MYH9,CSNK2B,PPP2R5B,SEMA6A,MED4,PSMA6,SHC1,CAP1,MED26,PPP2R1A,LAMTOR2,MYL6,MET,RELA,VCL,MED30,HSP90AB1,PSMB7,DLG4,MED16,MEF2D,ALCAM,MYL12A,BNIP2,CAMK2D,PPP2R5E,CDK19,WASL,PSMD3,CLASP2,CACNB3,PSMD6,AP2S1,NCSTN,BRAF,TCF3,MED18,RPS6KA5,PSMF1,PTPN11,JAK2,PSMD11,NRG4,HSP90AA1,ERBB3,UBB,STAT3,DUSP1,SPTAN1,PSMB6,VAV3,HES1,MED23,PSMB4,CDK8,ARHGEF12,EPHA5,PSMD4,MARK3,SRGAP3,POLR2A,UBC,MAP2K6,KBTBD7,RBPJ,PSME3
R-HSA-445095	Interaction between L1 and Ankyrins	0.999035790741659	-0.000964674407112381	29	2	0.000878734622144112	2276	8202	6323,6709	SCN1A,SPTAN1
R-HSA-1566948	Elastic fibre formation	0.999084567753582	-0.00091585151040779	42	4	0.00175746924428822	2276	8202	4052,4236,3688,4015	LTBP1,MFAP1,ITGB1,LOX
R-HSA-5654228	Phospholipase C-mediated cascade; FGFR4	0.999118370394363	-0.000882018469591006	48	5	0.00219683655536028	2276	8202	805,5581,10768,5566,5573	CALM2,PRKCE,AHCYL1,PRKACA,PRKAR1A
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	0.999191576411386	-0.000808750539185076	54	6	0.00263620386643234	2276	8202	1294,5339,7092,1288,4015,3914	COL7A1,PLEC,TLL1,COL4A6,LOX,LAMB3
R-HSA-5423646	Aflatoxin activation and detoxification	0.999224085495718	-0.000776215681742685	22	1	0.000439367311072056	2276	8202	4259	MGST3
R-HSA-140837	Intrinsic Pathway of Fibrin Clot Formation	0.999224085495718	-0.000776215681742685	22	1	0.000439367311072056	2276	8202	5547	PRCP
R-HSA-5655332	Signaling by FGFR3 in disease	0.999224085495718	-0.000776215681742685	22	1	0.000439367311072056	2276	8202	3845	KRAS
R-HSA-1474290	Collagen formation	0.999297129749022	-0.000703117380079143	86	12	0.00527240773286467	2276	8202	5479,7092,5034,79709,1294,5339,871,8985,1288,1303,3914,4015	PPIB,TLL1,P4HB,COLGALT1,COL7A1,PLEC,SERPINH1,PLOD3,COL4A6,COL12A1,LAMB3,LOX
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	0.999311294760622	-0.000688942505774921	49	5	0.00219683655536028	2276	8202	805,5581,10768,5566,5573	CALM2,PRKCE,AHCYL1,PRKACA,PRKAR1A
R-HSA-977443	GABA receptor activation	0.999362310032624	-0.000637893378103557	55	6	0.00263620386643234	2276	8202	2771,2773,2787,2783,23229,2788	GNAI2,GNAI3,GNG5,GNB2,ARHGEF9,GNG7
R-HSA-983712	Ion channel transport	0.999420655212658	-0.000579512672378573	198	36	0.015817223198594	2276	8202	523,1831,10396,5894,23327,51076,488,1185,23678,6717,6446,23545,51606,7314,529,9114,53373,57578,1183,1182,7311,219931,196527,535,148229,57205,7316,374868,476,51382,6233,483,528,150159,23229,26133	ATP6V1A,TSC22D3,ATP8A1,RAF1,NEDD4L,CUTC,ATP2A2,CLCN6,SGK3,SRI,SGK1,ATP6V0A2,ATP6V1H,UBB,ATP6V1E1,ATP6V0D1,TPCN1,UNC79,CLCN4,CLCN3,UBA52,TPCN2,ANO6,ATP6V0A1,ATP8B3,ATP10D,UBC,ATP9B,ATP1A1,ATP6V1D,RPS27A,ATP1B3,ATP6V1C1,SLC9B1,ARHGEF9,TRPC4AP
R-HSA-2022928	HS-GAG biosynthesis	0.999466118081391	-0.000534024484305283	31	2	0.000878734622144112	2276	8202	6382,26035	SDC1,GLCE
R-HSA-1442490	Collagen degradation	0.99949522867555	-0.000504898764381953	38	3	0.00131810193321617	2276	8202	8754,6868,1303	ADAM9,ADAM17,COL12A1
R-HSA-166658	Complement cascade	0.99949522867555	-0.000504898764381953	38	3	0.00131810193321617	2276	8202	966,1604,725	CD59,CD55,C4BPB
R-HSA-5654221	Phospholipase C-mediated cascade; FGFR2	0.999581696581218	-0.000418390932062922	51	5	0.00219683655536028	2276	8202	805,5581,10768,5566,5573	CALM2,PRKCE,AHCYL1,PRKACA,PRKAR1A
R-HSA-392154	Nitric oxide stimulates guanylate cyclase	0.999595815657312	-0.00040426604719622	24	1	0.000439367311072056	2276	8202	8654	PDE5A
R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The  Postsynaptic Cell	0.999612645197811	-0.000387429843439039	142	23	0.0101054481546573	2276	8202	5170,10142,673,6237,5894,2788,1742,2773,5566,2783,9463,59283,805,817,6196,160,59345,163,51764,2771,2787,1175,23229	PDPK1,AKAP9,BRAF,RRAS,RAF1,GNG7,DLG4,GNAI3,PRKACA,GNB2,PICK1,CACNG8,CALM2,CAMK2D,RPS6KA2,AP2A1,GNB4,AP2B1,GNG13,GNAI2,GNG5,AP2S1,ARHGEF9
R-HSA-5669034	TNFs bind their physiological receptors	0.99970830327641	-0.000291739275353866	25	1	0.000439367311072056	2276	8202	8771	TNFRSF6B
R-HSA-3295583	TRP channels	0.99970830327641	-0.000291739275353866	25	1	0.000439367311072056	2276	8202	26133	TRPC4AP
R-HSA-3560782	Diseases associated with glycosaminoglycan metabolism	0.999789494642543	-0.000210527516819462	26	1	0.000439367311072056	2276	8202	6382	SDC1
R-HSA-3781865	Diseases of glycosylation	0.999789494642543	-0.000210527516819462	26	1	0.000439367311072056	2276	8202	6382	SDC1
R-HSA-1474165	Reproduction	0.999789494642543	-0.000210527516819462	26	1	0.000439367311072056	2276	8202	57828	CATSPERG
R-HSA-975298	Ligand-gated ion channel transport	0.999789494642543	-0.000210527516819462	26	1	0.000439367311072056	2276	8202	23229	ARHGEF9
R-HSA-1187000	Fertilization	0.999789494642543	-0.000210527516819462	26	1	0.000439367311072056	2276	8202	57828	CATSPERG
R-HSA-373080	Class B/2 (Secretin family receptors)	0.999798347474919	-0.000201672859684721	87	11	0.00483304042179262	2276	8202	30817,1604,59345,80326,2788,976,51764,2535,2787,2783,8321	ADGRE2,CD55,GNB4,WNT10A,GNG7,ADGRE5,GNG13,FZD2,GNG5,GNB2,FZD1
R-HSA-1638091	Heparan sulfate/heparin (HS-GAG) metabolism	0.999804142473067	-0.00019587670952309	54	5	0.00219683655536028	2276	8202	10855,6382,2990,26035,26229	HPSE,SDC1,GUSB,GLCE,B3GAT3
R-HSA-73923	Lipid digestion, mobilization, and transport	0.999809675112724	-0.000190343001356017	60	6	0.00263620386643234	2276	8202	5500,51128,857,6382,5566,5034	PPP1CB,SAR1B,CAV1,SDC1,PRKACA,P4HB
R-HSA-975634	Retinoid metabolism and transport	0.999834814095487	-0.000165199549206873	42	3	0.00131810193321617	2276	8202	53630,26020,6382	BCO1,LRP10,SDC1
R-HSA-375280	Amine ligand-binding receptors	0.999834814095487	-0.000165199549206873	42	3	0.00131810193321617	2276	8202	154,3361,3269	ADRB2,HTR5A,HRH1
R-HSA-5655253	Signaling by FGFR2 in disease	0.999848094226435	-0.000151917312415446	27	1	0.000439367311072056	2276	8202	3845	KRAS
R-HSA-2142753	Arachidonic acid metabolism	0.999848325719784	-0.000151685783922588	55	5	0.00219683655536028	2276	8202	5743,10728,158584,2879,1545	PTGS2,PTGES3,FAAH2,GPX4,CYP1B1
R-HSA-419037	NCAM1 interactions	0.999911248355055	-8.87555836053563e-05	37	2	0.000878734622144112	2276	8202	784,783	CACNB3,CACNB2
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	0.999951485760945	-4.85154159090423e-05	39	2	0.000878734622144112	2276	8202	5547,2152	PRCP,F3
R-HSA-5173214	O-glycosylation of TSR domain-containing proteins	0.999951485760945	-4.85154159090423e-05	39	2	0.000878734622144112	2276	8202	11174,23275	ADAMTS6,POFUT2
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.9999681097926	-3.18907159035719e-05	61	5	0.00219683655536028	2276	8202	8503,145957,2065,5296,5781	PIK3R3,NRG4,ERBB3,PIK3R2,PTPN11
R-HSA-211897	Cytochrome P450 - arranged by substrate type	0.9999681097926	-3.18907159035719e-05	61	5	0.00219683655536028	2276	8202	1595,112812,10858,2232,1545	CYP51A1,FDX1L,CYP46A1,FDXR,CYP1B1
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.999973715941691	-2.62844037408403e-05	424	83	0.0364674868189807	2276	8202	161742,10142,200734,1848,4763,5894,5604,8527,5526,2783,805,5707,6196,5687,5696,6464,5518,5296,28956,11221,8503,7414,2787,7311,10287,2788,5695,1742,5529,817,5719,26090,6233,5714,5709,59345,4296,5690,5527,5705,9861,5700,5528,284,5689,9170,5693,673,2335,7094,5245,5713,5997,5715,1847,9491,5581,3717,145957,51764,5717,2065,5598,7314,5686,1843,6709,5694,5692,5702,1906,5682,3845,5710,4140,5691,7316,257313,369,221955,84078,10197,3269	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,DGKD,PPP2R5B,GNB2,CALM2,PSMD1,RPS6KA2,PSMA6,PSMB8,SHC1,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,VCL,GNG5,UBA52,RGS19,GNG7,PSMB7,DLG4,PPP2R5E,CAMK2D,PSMD13,ABHD12,RPS27A,PSMD8,PSMD3,GNB4,MAP3K11,PSMB2,PPP2R5C,PSMC5,PSMD6,PSMC1,PPP2R5D,ANGPT1,PSMB1,LPAR2,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,RGS2,PSMD9,DUSP5,PSMF1,PRKCE,JAK2,NRG4,GNG13,PSMD11,ERBB3,MAPK7,UBB,PSMA5,DUSP1,SPTAN1,PSMB6,PSMB4,PSMC3,EDN1,PSMA1,KRAS,PSMD4,MARK3,PSMB3,UBC,UTS2B,ARAF,DAGLB,KBTBD7,PSME3,HRH1
R-HSA-1630316	Glycosaminoglycan metabolism	0.999975802278549	-2.41980142208272e-05	123	16	0.0070298769771529	2276	8202	3161,337876,10678,50515,2990,26229,6382,26035,6484,10855,8372,6548,3373,6483,1836,8704	HMMR,CHSY3,B3GNT2,CHST11,GUSB,B3GAT3,SDC1,GLCE,ST3GAL4,HPSE,HYAL3,SLC9A1,HYAL1,ST3GAL2,SLC26A2,B4GALT2
R-HSA-109582	Hemostasis	0.999981392381752	-1.86077913717806e-05	515	104	0.0456942003514939	2276	8202	5894,7157,8527,8350,50848,5526,11004,25942,5566,2783,23028,2152,3833,805,7465,6464,488,10487,998,6281,5518,6786,5296,8503,3660,3835,10411,81928,7414,2787,3920,6520,10257,208,2788,3309,5868,87,3021,857,2773,7114,1525,3796,5529,55669,5889,64145,26090,59345,226,25970,3688,6814,5527,302,5528,23764,284,3066,5573,2335,4973,967,7094,5552,22927,11311,3831,682,29127,5478,5581,5770,23657,829,5781,653604,3717,51764,2771,5170,10451,10112,9948,11069,813,10362,8654,23186,3845,6810,3832,8165,2768,24137,221955,5547,2886,6566,7534,483,1062,11216	RAF1,TP53,DGKD,HIST1H3A,F11R,PPP2R5B,KIF2C,SIN3A,PRKACA,GNB2,KDM1A,F3,KIFC1,CALM2,WEE1,SHC1,ATP2A2,CAP1,CDC42,S100A10,PPP2R1A,STIM1,PIK3R2,PIK3R3,IRF2,KIF22,RAPGEF3,CABLES2,VCL,GNG5,LAMP2,SLC3A2,ABCC4,AKT2,GNG7,HSPA5,RAB5A,ACTN1,H3F3B,CAV1,GNAI3,TMSB4X,CXADR,KIF2A,PPP2R5E,MFN1,RAD51C,RBSN,ABHD12,GNB4,ALDOA,SH2B1,ITGB1,STXBP3,PPP2R5C,ANXA2,PPP2R5D,MAFF,ANGPT1,HDAC2,PRKAR1A,FN1,OLR1,CD63,TLN1,SRGN,HABP4,VPS45,KLC1,BSG,RACGAP1,PPIA,PRKCE,PTPN1,SLC7A11,CAPZA1,PTPN11,HIST2H3D,JAK2,GNG13,GNAI2,PDPK1,VAV3,KIF20A,WDR1,RAPGEF4,CALU,HMG20B,PDE5A,RCOR1,KRAS,STX4,KIF11,AKAP1,GNA12,KIF4A,DAGLB,PRCP,GRB7,SLC16A1,YWHAZ,ATP1B3,CENPE,AKAP10
R-HSA-1474228	Degradation of the extracellular matrix	0.999988903460081	-1.10966014856498e-05	89	9	0.00395430579964851	2276	8202	6868,7092,8754,682,826,5663,23385,1303,3914	ADAM17,TLL1,ADAM9,BSG,CAPNS1,PSEN1,NCSTN,COL12A1,LAMB3
R-HSA-382551	Transmembrane transport of small molecules	0.999993028113924	-6.97191037935221e-06	586	119	0.0522847100175747	2276	8202	10058,6517,21,23511,64924,523,29988,1831,10396,5894,89845,9197,81614,2030,6542,3163,5566,6574,51076,2783,27173,488,5825,55746,8504,5002,23446,1185,6717,20,154091,9972,1836,529,57468,2787,57578,1183,1182,6520,7311,10257,81539,64116,2788,535,55343,4891,9631,26503,8021,28982,57205,5903,476,2542,6233,59345,9497,91749,150159,8086,5573,8480,53371,8884,6522,23327,9990,8766,7037,23165,129401,10347,10351,1317,8894,4927,23657,55676,84912,23678,1468,6446,6548,23545,51764,51606,7314,10559,9114,53373,5824,57185,2512,196527,219931,148229,92579,23,7316,374868,6533,51382,1497,84061,1968,282679,6566,23636,11194,483,7779,528,124935,6583,23229,9818,26133	ABCB6,SLC2A4,ABCA3,NUP188,SLC30A5,ATP6V1A,SLC2A8,TSC22D3,ATP8A1,RAF1,ABCC10,SLC33A1,NIPA2,SLC29A1,SLC7A2,HMOX2,PRKACA,SLC20A1,CUTC,GNB2,SLC39A1,ATP2A2,ABCD3,NUP133,PEX3,SLC22A18,SLC44A1,CLCN6,SRI,ABCA2,SLC2A12,NUP153,SLC26A2,ATP6V1E1,SLC12A5,GNG5,UNC79,CLCN4,CLCN3,SLC3A2,UBA52,ABCC4,SLC38A1,SLC39A8,GNG7,ATP6V0A1,SLC35C1,SLC11A2,NUP155,SLC17A5,NUP214,FLVCR1,ATP10D,RANBP2,ATP1A1,SLC37A4,RPS27A,GNB4,SLC4A7,KIAA1919,SLC9B1,AAAS,PRKAR1A,RAE1,NUP54,SLC5A6,SLC4A2,NEDD4L,SLC12A6,RAB11A,TFRC,NUP205,NUP35,ABCA7,ABCA8,SLC31A1,EIF2S2,NUP88,SLC7A11,SLC30A6,SLC35B4,SGK3,SLC25A10,SGK1,SLC9A1,ATP6V0A2,GNG13,ATP6V1H,UBB,SLC35A1,ATP6V0D1,TPCN1,PEX19,NIPAL3,FTL,ANO6,TPCN2,ATP8B3,G6PC3,ABCF1,UBC,ATP9B,SLC6A6,ATP6V1D,CTNS,MAGT1,EIF2S3,AQP11,SLC16A1,NUP62,ABCB8,ATP1B3,SLC30A1,ATP6V1C1,SLC43A2,SLC22A4,ARHGEF9,NUP58,TRPC4AP
R-HSA-216083	Integrin cell surface interactions	0.999993547084657	-6.45293616306571e-06	67	5	0.00219683655536028	2276	8202	682,50848,2335,1605,3688	BSG,F11R,FN1,DAG1,ITGB1
R-HSA-5173105	O-linked glycosylation	0.999994166092517	-5.83392450012877e-06	103	11	0.00483304042179262	2276	8202	6484,56913,4582,10678,6480,29071,63917,6483,11174,55568,23275	ST3GAL4,C1GALT1,MUC1,B3GNT2,ST6GAL1,C1GALT1C1,GALNT11,ST3GAL2,ADAMTS6,GALNT10,POFUT2
R-HSA-112315	Transmission across Chemical Synapses	0.99999519192016	-4.80809139909481e-06	210	32	0.0140597539543058	2276	8202	5170,10142,673,80331,6237,81539,5894,2788,3312,1742,6616,2773,5566,2783,9463,59283,805,2744,817,6196,783,160,59345,5864,4128,163,51764,784,2771,2787,1175,23229	PDPK1,AKAP9,BRAF,DNAJC5,RRAS,SLC38A1,RAF1,GNG7,HSPA8,DLG4,SNAP25,GNAI3,PRKACA,GNB2,PICK1,CACNG8,CALM2,GLS,CAMK2D,RPS6KA2,CACNB2,AP2A1,GNB4,RAB3A,MAOA,AP2B1,GNG13,CACNB3,GNAI2,GNG5,AP2S1,ARHGEF9
R-HSA-418555	G alpha (s) signalling events	0.999996497481918	-3.50252421576701e-06	127	15	0.00659050966608084	2276	8202	5141,1081,59345,2788,5150,5734,5151,51764,154,5144,27115,2771,2773,2783,2787	PDE4A,CGA,GNB4,GNG7,PDE7A,PTGER4,PDE8A,GNG13,ADRB2,PDE4D,PDE7B,GNAI2,GNAI3,GNB2,GNG5
R-HSA-420499	Class C/3 (Metabotropic glutamate/pheromone receptors)	0.999996982126803	-3.01787775071071e-06	39	1	0.000439367311072056	2276	8202	83756	TAS1R3
R-HSA-2187338	Visual phototransduction	0.999998747383641	-1.25261714393796e-06	98	9	0.00395430579964851	2276	8202	805,4836,157506,26020,53630,388531,6382,9249,222236	CALM2,NMT1,RDH10,LRP10,BCO1,RGS9BP,SDC1,DHRS3,NAPEPLD
R-HSA-3000178	ECM proteoglycans	0.99999973709318	-2.62906854331367e-07	56	2	0.000878734622144112	2276	8202	1605,3688	DAG1,ITGB1
R-HSA-211859	Biological oxidations	0.999999848051967	-1.519480443267e-07	194	25	0.0109841827768014	2276	8202	2954,4837,7360,2729,10858,4259,7358,25830,4548,2937,4552,10327,1595,27430,373156,79017,119391,112812,9,2232,4128,1836,55748,6820,1545	GSTZ1,NNMT,UGP2,GCLC,CYP46A1,MGST3,UGDH,SULT4A1,MTR,GSS,MTRR,AKR1A1,CYP51A1,MAT2B,GSTK1,GGCT,GSTO2,FDX1L,NAT1,FDXR,MAOA,SLC26A2,CNDP2,SULT2B1,CYP1B1
R-HSA-211945	Phase 1 - Functionalization of compounds	0.999999901123745	-9.88762601958576e-08	89	6	0.00263620386643234	2276	8202	1595,4128,112812,10858,2232,1545	CYP51A1,MAOA,FDX1L,CYP46A1,FDXR,CYP1B1
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	0.999999983094811	-1.69051894406359e-08	115	9	0.00395430579964851	2276	8202	79465,3133,3134,3688,567,3107,3105,1525,80329	ULBP3,HLA-E,HLA-F,ITGB1,B2M,HLA-C,HLA-A,CXADR,ULBP1
R-HSA-380108	Chemokine receptors bind chemokines	0.999999988458888	-1.1541112392527e-08	56	1	0.000439367311072056	2276	8202	2920	CXCL2
R-HSA-162582	Signal Transduction	0.999999999820331	-1.79668655483342e-10	2357	481	0.211335676625659	2276	8202	23092,3015,5565,54903,26160,8350,1488,6777,7531,4628,79003,8365,805,9183,6484,5707,63916,10193,57665,6194,8379,1785,163,54778,5494,10411,10097,1738,64223,5160,7311,26574,208,1454,2788,842,8550,3021,9212,8340,60485,2773,8239,8405,572,6498,5719,25936,6233,5714,25970,3688,4296,83756,5527,2932,81617,128312,3066,30817,4836,26524,5689,7375,3728,5562,4983,30849,7082,23327,90780,5715,2622,6242,3725,5581,55512,8878,80326,4609,23596,23545,5598,2771,9475,114793,10959,5915,7867,5702,11069,157506,6016,154,2002,5691,8202,51422,160,57728,2886,8481,116985,171177,976,84455,10109,161742,200734,5607,1848,9322,523,10928,5894,10096,5166,4627,324,1147,1460,54509,5566,8027,2783,1399,595,6464,488,57680,9110,51377,8364,55072,28956,835,4637,1027,30851,388531,253260,5144,9828,5970,8321,5163,2931,8767,57120,1894,1871,1742,535,701,6232,27115,7297,10014,7532,79682,3796,5529,8517,817,8362,7514,79980,9759,27018,558,55764,4085,6772,10272,3014,6400,5500,9742,6198,5573,23112,6396,673,7186,57591,57142,84335,9252,5929,55055,9491,4734,79172,91687,9138,5781,9055,145957,2065,6885,7314,4091,10253,10726,5694,6709,51421,5170,7050,10451,5289,55789,11130,7128,1975,607,9101,1906,10399,5710,4140,7316,9901,8772,2768,3569,10023,5597,5150,2863,1062,10197,57082,7533,51699,8945,23081,142678,261734,8936,4763,50848,11004,9294,2535,10144,81624,10013,6382,329,30011,9765,6196,5696,1499,998,84986,5034,5296,9241,11221,9070,2017,1977,529,147179,9754,8331,6453,11140,1604,1058,723790,4690,51107,10287,85236,5571,857,983,27005,7415,6009,80319,4192,59345,1213,2185,5690,1500,5705,5700,284,5528,8650,64857,9958,5125,7323,5693,4659,2335,9886,7094,1495,1063,5245,4092,5713,5900,29924,3831,4205,29127,1111,5870,3337,5997,23239,9249,8347,1847,5584,53630,4040,9735,51606,9794,9114,5686,90268,5058,10152,6755,23433,5141,7090,2060,5682,5151,3845,84447,989,8368,10552,6934,6257,7248,369,23645,389541,4660,26020,23221,7534,286205,6907,81847,192669,10163,5564,10142,1540,4771,2475,1875,7157,5604,8527,5526,8658,23028,27237,55737,79809,5164,5687,55845,8651,8555,55746,5518,9928,3551,112724,8503,10768,59349,7414,3017,11171,2787,10006,1856,2735,2241,5914,348235,330,1081,991,5734,5695,23401,10971,55914,3361,995,5903,8607,26090,5933,6778,8976,5709,7289,6722,23122,9861,151648,4343,10454,1175,23385,1030,9170,659,257397,8367,11113,8887,55143,2920,3633,1452,8360,9559,5586,466,5770,151246,3726,9181,653604,3717,5717,51764,3320,79019,6774,6199,6667,1843,7091,1455,3280,6868,5692,1024,3164,23365,8363,222236,1729,257313,22943,401541,51592,5467,3012,51382,221955,332,84078,23220,147841,3516,528,8556,23229,3269	ARHGAP26,H2AFZ,PRKAB2,MKS1,IFT172,HIST1H3A,CTBP2,STAT5B,YWHAE,MYH10,MIS12,HIST1H4H,CALM2,ZW10,ST3GAL4,PSMD1,ELMO2,RNF41,RDH14,RPS6,MAD1L1,DNM2,AP2B1,RNF111,PPM1A,RAPGEF3,ACTR2,DLD,MLST8,PDHA1,UBA52,AATF,AKT2,CSNK1E,GNG7,CASP9,MAPKAPK5,H3F3B,AURKB,HIST1H2BL,SAV1,GNAI3,USP9X,SPOP,BAD,SKIL,PSMD13,NSL1,RPS27A,PSMD8,SH2B1,ITGB1,MAP3K11,TAS1R3,PPP2R5C,GSK3B,CAB39L,HIST3H2BB,HDAC2,ADGRE2,NMT1,LATS2,PSMB1,USP4,JUP,PRKAA1,OPHN1,PIK3R4,TJP1,NEDD4L,PYGO2,PSMD9,GAS8,RTKN,JUN,PRKCE,SMPD3,SQSTM1,WNT10A,MYC,OPN3,ATP6V0A2,MAPK7,GNAI2,ROCK2,FMNL2,TMED2,RARB,MAPKAPK3,PSMC3,RAPGEF4,RDH10,RIT1,ADRB2,ELK1,PSMB3,NCOA3,PRKAG2,AP2A1,WDR19,GRB7,OFD1,ARAP1,RHOV,ADGRE5,EFCAB7,ARPC2,SPRED1,SPRED2,MAP2K5,DUSP6,TRIP10,ATP6V1A,RALBP1,RAF1,ACTR3,PDK4,MYH9,APC,CHUK,CSNK2B,RHOF,PRKACA,STAM,GNB2,CRKL,CCND1,SHC1,ATP2A2,CHD8,MTMR4,UCHL5,HIST1H4C,RNF31,LAMTOR2,CASP2,MYL6,CDKN1B,TAX1BP3,RGS9BP,RICTOR,PDE4D,ARHGEF17,RELA,FZD1,PDK1,GSK3A,RIPK2,GOPC,ECT2,E2F3,DLG4,ATP6V0A1,BUB1B,RPS27,PDE7B,TYK2,HDAC5,YWHAG,CENPU,KIF2A,PPP2R5E,IKBKG,CAMK2D,HIST1H4K,XPO1,DSN1,HDAC4,NGFRAP1,AXL,IFT122,MAD2L1,STAT1,FSTL3,H2AFX,SEL1L,PPP1CB,IFT140,RPS6KB1,PRKAR1A,TNRC6B,SEC13,BRAF,TRAF2,MKL1,RTN4,AKT1S1,RPS6KA5,RBBP5,ZWILCH,PSMF1,NEDD4,CENPO,CENPL,ARHGEF1,PTPN11,PRC1,NRG4,ERBB3,MAP3K7,UBB,SMAD6,SPRY2,NUDC,PSMB6,SPTAN1,AMOTL2,PDPK1,TGIF1,VAV3,PIK3C3,DEPDC1B,ZWINT,TNFAIP3,EIF4B,BCL9,USP8,EDN1,GNB2L1,PSMD4,MARK3,UBC,SRGAP3,FADD,GNA12,IL6,FRAT1,MAPK6,PDE7A,GPR39,CENPE,PSME3,CASC5,YWHAH,VPS29,BTRC,KDM4C,MIB2,NPHP4,WASF1,NF1,F11R,KIF2C,S1PR2,FZD2,FAM13A,DIAPH3,HDAC6,SDC1,BIRC2,SH3KBP1,ZFYVE16,RPS6KA2,PSMB8,CTNNB1,CDC42,ARHGAP19,P4HB,PIK3R2,NOG,DUSP10,ASH2L,CTTN,EIF4E,ATP6V1E1,WIPF2,STARD8,HIST1H2AJ,ITSN1,CDC37,CD55,CENPA,HIST2H2AA4,NCK1,APH1A,RGS19,HIST1H2BK,PRKAG1,CAV1,CDK1,USP21,VCP,RHEB,CXXC4,MDK,GNB4,CLTC,PTK2B,PSMB2,CTNND1,PSMC5,PSMC1,ANGPT1,PPP2R5D,NUMB,PLEKHG2,USP15,PCSK5,UBE2D3,PSMB5,PPP1R12A,FN1,RHOBTB1,TLN1,CTNNA1,CENPF,PHB,SMAD7,PSMD7,RALGDS,EPN1,KLC1,MEF2A,RACGAP1,CHEK1,RAB6A,DNAJB1,RGS2,PHLPP1,DHRS3,HIST1H2BC,DUSP5,PRKCI,BCO1,LRP6,KNTC1,ATP6V1H,MAML1,ATP6V0D1,PSMA5,OTULIN,PAK1,ABI2,SSTR5,RHOQ,PDE4A,TLE3,EPS15,PSMA1,PDE8A,KRAS,SYVN1,SEPT7,HIST1H4L,ARPC1A,TCF7L2,RXRB,TSC1,ARAF,PPP1R15A,LAMTOR4,PPP1R12B,LRP10,RHOBTB2,YWHAZ,SCAI,TBL1X,RNF146,AGO3,WASF2,PRKAB1,AKAP9,CYLD,NF2,MTOR,E2F5,TP53,MAP2K1,DGKD,PPP2R5B,TNKS,KDM1A,ARHGEF16,VPS35,TTC21B,PDK2,PSMA6,BRK1,SOCS1,CDC14B,NUP133,PPP2R1A,KIF14,IKBKB,RDH13,PIK3R3,AHCYL1,KLHL12,VCL,HIST1H2BD,STRAP,GNG5,ABI1,DVL2,GLI1,FER,RARA,SKA2,BIRC3,CGA,CDC20,PTGER4,PSMB7,FRAT2,YWHAQ,ERBB2IP,HTR5A,CDC25C,RANBP2,RUVBL1,ABHD12,RBL1,STAT6,WASL,PSMD3,TULP3,SRF,CLASP2,PSMD6,SGOL1,MOV10,TAB1,AP2S1,NCSTN,CDKN2B,LPAR2,BMPR2,TAB3,HIST1H4E,CIT,TAX1BP1,CDCA8,CXCL2,INPP5B,CSNK1A1,HIST1H4D,VPS26A,PKN2,ATF1,PTPN1,SGOL2,JUNB,ARHGEF2,HIST2H3D,JAK2,PSMD11,GNG13,HSP90AA1,CENPM,STAT3,RPS6KB2,SP1,DUSP1,TLE4,CSNK1G2,HES1,ADAM17,PSMB4,CDK8,NR4A1,ARHGEF12,HIST1H4J,NAPEPLD,DIAPH1,UTS2B,DKK1,CENPP,TRIM33,PPARD,HIST1H2AE,ATP6V1D,DAGLB,BIRC5,KBTBD7,DTX4,SPC24,RBPJ,ATP6V1C1,CDC14A,ARHGEF9,HRH1
R-HSA-372790	Signaling by GPCR	0.99999999984458	-1.55420322462643e-10	1230	124	0.054481546572935	2276	8202	161742,10142,200734,1848,4763,5894,5604,8527,5526,9294,2535,5566,2783,27237,805,5707,5696,6196,5687,6464,998,5518,5296,28956,11221,8503,5144,10768,9828,7414,2787,6453,8321,1604,7311,1081,208,10287,2788,1894,5695,5734,1742,3361,27115,2773,5529,817,5719,26090,6233,5714,5709,59345,4296,83756,5527,5690,5705,9861,5700,5528,284,64857,5573,30817,5689,9170,5693,673,2335,7094,5245,5713,2920,5997,5715,9491,1847,5581,80326,9138,23596,9181,3717,145957,51764,5717,2065,5598,7314,2771,9475,5686,5694,1843,6709,5170,10451,6755,5692,5141,5702,1906,5682,3845,5151,23365,154,5710,4140,5691,257313,7316,2768,369,221955,84078,5150,976,2863,10197,23229,3269	SPRED1,AKAP9,SPRED2,DUSP6,NF1,RAF1,MAP2K1,DGKD,PPP2R5B,S1PR2,FZD2,PRKACA,GNB2,ARHGEF16,CALM2,PSMD1,PSMB8,RPS6KA2,PSMA6,SHC1,CDC42,PPP2R1A,PIK3R2,LAMTOR2,DUSP10,PIK3R3,PDE4D,AHCYL1,ARHGEF17,VCL,GNG5,ITSN1,FZD1,CD55,UBA52,CGA,AKT2,RGS19,GNG7,ECT2,PSMB7,PTGER4,DLG4,HTR5A,PDE7B,GNAI3,PPP2R5E,CAMK2D,PSMD13,ABHD12,RPS27A,PSMD8,PSMD3,GNB4,MAP3K11,TAS1R3,PPP2R5C,PSMB2,PSMC5,PSMD6,PSMC1,PPP2R5D,ANGPT1,PLEKHG2,PRKAR1A,ADGRE2,PSMB1,LPAR2,PSMB5,BRAF,FN1,TLN1,PHB,PSMD7,CXCL2,RGS2,PSMD9,PSMF1,DUSP5,PRKCE,WNT10A,ARHGEF1,OPN3,ARHGEF2,JAK2,NRG4,GNG13,PSMD11,ERBB3,MAPK7,UBB,GNAI2,ROCK2,PSMA5,PSMB6,DUSP1,SPTAN1,PDPK1,VAV3,SSTR5,PSMB4,PDE4A,PSMC3,EDN1,PSMA1,KRAS,PDE8A,ARHGEF12,ADRB2,PSMD4,MARK3,PSMB3,UTS2B,UBC,GNA12,ARAF,DAGLB,KBTBD7,PDE7A,ADGRE5,GPR39,PSME3,ARHGEF9,HRH1
R-HSA-388396	GPCR downstream signaling	0.999999999854671	-1.45329380779502e-10	928	49	0.0215289982425308	2276	8202	9170,8527,2920,9294,5997,2783,27237,5581,6464,998,5296,9138,23596,8503,9181,3717,51764,5144,9828,2771,9475,2787,6453,5170,10451,6755,5141,1081,208,10287,2788,1894,5734,1906,5151,23365,154,27115,3361,2773,257313,2768,221955,26090,59345,5150,23229,64857,3269	LPAR2,DGKD,CXCL2,S1PR2,RGS2,GNB2,ARHGEF16,PRKCE,SHC1,CDC42,PIK3R2,ARHGEF1,OPN3,PIK3R3,ARHGEF2,JAK2,GNG13,PDE4D,ARHGEF17,GNAI2,ROCK2,GNG5,ITSN1,PDPK1,VAV3,SSTR5,PDE4A,CGA,AKT2,RGS19,GNG7,ECT2,PTGER4,EDN1,PDE8A,ARHGEF12,ADRB2,PDE7B,HTR5A,GNAI3,UTS2B,GNA12,DAGLB,ABHD12,GNB4,PDE7A,ARHGEF9,PLEKHG2,HRH1
R-HSA-500792	GPCR ligand binding	0.999999999882417	-1.1758298135598e-10	444	25	0.0109841827768014	2276	8202	30817,6755,9170,1604,1081,2788,1906,5734,154,2920,9294,2535,3361,2783,257313,80326,59345,83756,23596,976,51764,2863,2787,3269,8321	ADGRE2,SSTR5,LPAR2,CD55,CGA,GNG7,EDN1,PTGER4,ADRB2,CXCL2,S1PR2,FZD2,HTR5A,GNB2,UTS2B,WNT10A,GNB4,TAS1R3,OPN3,ADGRE5,GNG13,GPR39,GNG5,HRH1,FZD1
R-HSA-381753	Olfactory Signaling Pathway	0.999999999897247	-1.0275344291847e-10	381	0	0	2276	8202
R-HSA-1296071	Potassium Channels	0.999999999917918	-8.20821705671286e-11	99	4	0.00175746924428822	2276	8202	3775,2787,2783,2788	KCNK1,GNG5,GNB2,GNG7
R-HSA-112316	Neuronal System	0.999999999924656	-7.53443433320031e-11	289	34	0.0149384885764499	2276	8202	10142,673,80331,5894,5566,2783,9463,24145,59283,805,6196,783,5864,163,51764,2771,2787,5170,6237,81539,3312,2788,1742,6616,2773,2744,817,3775,59345,160,4128,784,23229,1175	AKAP9,BRAF,DNAJC5,RAF1,PRKACA,GNB2,PICK1,PANX1,CACNG8,CALM2,RPS6KA2,CACNB2,RAB3A,AP2B1,GNG13,GNAI2,GNG5,PDPK1,RRAS,SLC38A1,HSPA8,GNG7,DLG4,SNAP25,GNAI3,GLS,CAMK2D,KCNK1,GNB4,AP2A1,MAOA,CACNB3,ARHGEF9,AP2S1
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	0.999999999927312	-7.26884418871763e-11	318	13	0.00571177504393673	2276	8202	6755,9170,1081,1906,23596,5734,2863,154,2920,9294,3361,257313,3269	SSTR5,LPAR2,CGA,EDN1,OPN3,PTGER4,GPR39,ADRB2,CXCL2,S1PR2,HTR5A,UTS2B,HRH1
R-HSA-1474244	Extracellular matrix organization	0.999999999929951	-7.00487809070112e-11	267	27	0.0118629173989455	2276	8202	4052,5479,6868,7092,2335,682,79709,826,87,50848,1294,5339,6382,5663,1605,1303,3914,5034,4236,3688,51399,8754,871,8985,1288,23385,4015	LTBP1,PPIB,ADAM17,TLL1,FN1,BSG,COLGALT1,CAPNS1,ACTN1,F11R,COL7A1,PLEC,SDC1,PSEN1,DAG1,COL12A1,LAMB3,P4HB,MFAP1,ITGB1,TRAPPC4,ADAM9,SERPINH1,PLOD3,COL4A6,NCSTN,LOX
R-HSA-416476	G alpha (q) signalling events	0.999999999935497	-6.45024889770017e-11	190	17	0.00746924428822496	2276	8202	9170,10287,2788,1906,8527,5997,2783,257313,5581,221955,26090,59345,5296,8503,51764,2787,3269	LPAR2,RGS19,GNG7,EDN1,DGKD,RGS2,GNB2,UTS2B,PRKCE,DAGLB,ABHD12,GNB4,PIK3R2,PIK3R3,GNG13,GNG5,HRH1
R-HSA-418594	G alpha (i) signalling events	0.999999999946416	-5.35836331798854e-11	236	14	0.00615114235500879	2276	8202	6755,9170,59345,10287,2788,23596,51764,2920,9294,3361,2771,2773,2787,2783	SSTR5,LPAR2,GNB4,RGS19,GNG7,OPN3,GNG13,CXCL2,S1PR2,HTR5A,GNAI2,GNAI3,GNG5,GNB2
R-HSA-375276	Peptide ligand-binding receptors	0.999999999960303	-3.96973230316337e-11	193	4	0.00175746924428822	2276	8202	6755,2920,257313,1906	SSTR5,CXCL2,UTS2B,EDN1
R-HSA-916853	Degradation of GABA	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-205017	NFG and proNGF binds to p75NTR	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-168277	Influenza Virus Induced Apoptosis	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-1483101	Synthesis of PS	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-211728	Regulation of PAK-2p34 activity by PS-GAP/RHG10	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-176034	Interactions of Tat with host cellular proteins	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-1299361	TWIK-related alkaline pH activated K+ channel (TALK)	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-177162	Conjugation of phenylacetate with glutamine	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-5579031	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-141334	PAOs oxidise polyamines to amines	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-844623	The IPAF inflammasome	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-5638303	Inhibition of Signaling by Overexpressed EGFR	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-164939	Nef mediated downregulation of CD28 cell surface expression	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-1299316	TWIK-releated acid-sensitive K+ channel (TASK)	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-3642279	TGFBR2 MSI Frameshift Mutants in Cancer	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-888568	GABA synthesis	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-190872	Transport of connexons to the plasma membrane	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-5687868	Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-428559	Proton-coupled neutral amino acid transporters	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-211994	Sterols are 12-hydroxylated by CYP8B1	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-5688354	Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-5357609	Glycogen storage disease type II (GAA)	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-351143	Agmatine biosynthesis	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-211736	Stimulation of the cell death response by PAK-2p34	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-187042	TRKA activation by NGF	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-75094	Formation of the Editosome	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-166020	Transfer of LPS from LBP carrier to CD14	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-168315	Inhibition of Host mRNA Processing and RNA Silencing	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-5602566	TICAM1 deficiency - HSE	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-5619107	Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC)	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-111995	phospho-PLA2 pathway	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-451307	Activation of Na-permeable Kainate Receptors	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-3858516	Glycogen storage disease type 0 (liver GYS2)	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-432030	Transport of glycerol from adipocytes to the liver by Aquaporins	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-163754	Insulin effects increased synthesis of Xylulose-5-Phosphate	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-111452	Activation and oligomerization of BAK protein	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-72200	mRNA Editing: C to U Conversion	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-5638302	Signaling by Overexpressed Wild-Type EGFR in Cancer	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-5662702	Melanin biosynthesis	0.999999999978606	-2.13944278959488e-11	2	0	0	2276	8202
R-HSA-5602680	MyD88 deficiency (TLR5)	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-265473	Trafficking of dietary sterols	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-5653890	Lactose synthesis	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-70350	Fructose catabolism	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-3359463	Defective CUBN causes hereditary megaloblastic anemia 1	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-1483152	Hydrolysis of LPE	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-77108	Utilization of Ketone Bodies	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-193681	Ceramide signalling	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-3304347	Loss of Function of SMAD4 in Cancer	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-5357572	Lysosomal glycogen catabolism	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-190704	Oligomerization of connexins into connexons	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-3359462	Defective AMN causes hereditary megaloblastic anemia 1	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-1299503	TWIK related potassium channel (TREK)	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-1296067	Potassium transport channels	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-392023	Adrenaline signalling through Alpha-2 adrenergic receptor	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-2892245	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-977442	GABA A (rho) receptor activation	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-180897	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-190374	FGFR1c and Klotho ligand binding and activation	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-5250958	Toxicity of botulinum toxin type B (BoNT/B)	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-3296197	Hydroxycarboxylic acid-binding receptors	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-217271	FMO oxidises nucleophiles	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-5602571	TRAF3 deficiency - HSE	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-427589	Type II Na+/Pi cotransporters	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-444411	Rhesus glycoproteins mediate ammonium transport.	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-190827	Transport of connexins along the secretory pathway	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-844615	The AIM2 inflammasome	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-1307965	betaKlotho-mediated ligand binding	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-162699	Synthesis of dolichyl-phosphate mannose	0.999999999982866	-1.7133933161162e-11	3	0	0	2276	8202
R-HSA-1222499	Response of Mtb to phagocytosis	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-5340573	WNT ligand secretion is abrogated by the PORCN inhibitor LGK974	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-3359454	Defective TCN2 causes hereditary megaloblastic anemia	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-5602410	TLR3 deficiency - HSE	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-389542	NADPH regeneration	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-190840	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-1299344	TWIK-related spinal cord K+ channel (TRESK)	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-1839128	FGFR4 mutant receptor activation	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-2534343	Interaction With Cumulus Cells	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-3248023	Regulation by TREX1	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-1222352	Latent infection of Homo sapiens with Mycobacterium tuberculosis	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-480985	Synthesis of dolichyl-phosphate-glucose	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-169131	Inhibition of PKR	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-1855231	Synthesis of IPs in the ER lumen	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-5657655	MGMT-mediated DNA damage reversal	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-211957	Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-1299287	Tandem pore domain halothane-inhibited K+ channel (THIK)	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-1483076	Synthesis of CL	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-171286	Synthesis and processing of ENV and VPU	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-168275	Entry of Influenza Virion into Host Cell via Endocytosis	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-140180	COX reactions	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-5619058	Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-5678895	Defective CFTR causes cystic fibrosis	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-5619110	Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-1839120	Signaling by FGFR1 amplification mutants	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-5250982	Toxicity of tetanus toxin (TeNT)	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-2023837	Signaling by FGFR2 amplification mutants	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-1222449	Mtb iron assimilation by chelation	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-1300645	Acrosome Reaction	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-3359457	Defective GIF causes intrinsic factor deficiency	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-975574	Reactions specific to the hybrid N-glycan synthesis pathway	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-2978092	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-2142696	Synthesis of Hepoxilins (HX) and Trioxilins (TrX)	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-5619084	ABC transporter disorders	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-1483196	PI and PC transport between ER and Golgi membranes	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-5602415	UNC93B1 deficiency - HSE	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-2033515	t(4;14) translocations of FGFR3	0.999999999989854	-1.01460506662931e-11	1	0	0	2276	8202
R-HSA-3642278	Loss of Function of TGFBR2 in Cancer	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-3645790	TGFBR2 Kinase Domain Mutants in Cancer	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-428542	Regulation of Commissural axon pathfinding by Slit and Robo	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-173736	Alternative complement activation	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-1296061	HCN channels	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-3656535	TGFBR1 LBD Mutants in Cancer	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-1296053	Classical Kir channels	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-69200	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-194306	Neurophilin interactions with VEGF and VEGFR	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-5603037	IRAK4 deficiency (TLR5)	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-888593	Reuptake of GABA	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-427975	Proton/oligopeptide cotransporters	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-3000497	Scavenging by Class H Receptors	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-399710	Activation of AMPA receptors	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-389599	Alpha-oxidation of phytanate	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-209905	Catecholamine biosynthesis	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-209563	Axonal growth stimulation	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-417973	Adenosine P1 receptors	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-428776	Class II GLUTs	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-5619099	Defective AVP causes neurohypophyseal diabetes insipidus (NDI)	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-1296025	ATP sensitive Potassium channels	0.99999999999637	-3.62989152624671e-12	4	0	0	2276	8202
R-HSA-1482883	Acyl chain remodeling of DAG and TAG	0.999999999997319	-2.68132581025468e-12	6	0	0	2276	8202
R-HSA-388479	Vasopressin-like receptors	0.999999999997319	-2.68132581025468e-12	6	0	0	2276	8202
R-HSA-171052	LDL-mediated lipid transport	0.999999999997319	-2.68132581025468e-12	6	0	0	2276	8202
R-HSA-190370	FGFR1b ligand binding and activation	0.999999999997319	-2.68132581025468e-12	6	0	0	2276	8202
R-HSA-2142700	Synthesis of Lipoxins (LX)	0.999999999997319	-2.68132581025468e-12	6	0	0	2276	8202
R-HSA-5693548	Sensing of DNA Double Strand Breaks	0.999999999997319	-2.68132581025468e-12	6	0	0	2276	8202
R-HSA-77111	Synthesis of Ketone Bodies	0.999999999997319	-2.68132581025468e-12	6	0	0	2276	8202
R-HSA-173623	Classical antibody-mediated complement activation	0.999999999997319	-2.68132581025468e-12	6	0	0	2276	8202
R-HSA-187015	Activation of TRKA receptors	0.999999999997319	-2.68132581025468e-12	6	0	0	2276	8202
R-HSA-211916	Vitamins	0.999999999997319	-2.68132581025468e-12	6	0	0	2276	8202
R-HSA-177135	Conjugation of benzoate with glycine	0.999999999997319	-2.68132581025468e-12	6	0	0	2276	8202
R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer	0.999999999997319	-2.68132581025468e-12	6	0	0	2276	8202
R-HSA-166662	Lectin pathway of complement activation	0.999999999997319	-2.68132581025468e-12	6	0	0	2276	8202
R-HSA-1912399	Pre-NOTCH Processing in the Endoplasmic Reticulum	0.999999999997319	-2.68132581025468e-12	6	0	0	2276	8202
R-HSA-390648	Muscarinic acetylcholine receptors	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-3000471	Scavenging by Class B Receptors	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-74713	IRS activation	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-1300652	Sperm:Oocyte Membrane Binding	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-2161517	Abacavir transmembrane transport	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-444209	Free fatty acid receptors	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-2142850	Hyaluronan biosynthesis and export	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-210746	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-390651	Dopamine receptors	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-187024	NGF-independant TRKA activation	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-2855086	Ficolins bind to repetitive carbohydrate structures on the target cell surface	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-380095	Tachykinin receptors bind tachykinins	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-2644607	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-561048	Organic anion transport	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-433137	Sodium-coupled sulphate, di- and tri-carboxylate transporters	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-2644605	FBXW7 Mutants and NOTCH1 in Cancer	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-391906	Leukotriene receptors	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-5624138	Trafficking of myristoylated proteins to the cilium	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-209931	Serotonin and melatonin biosynthesis	0.9999999999999	-1.00300410338372e-13	5	0	0	2276	8202
R-HSA-419812	Calcitonin-like ligand receptors	1.00000000000251	2.50810012712157e-12	10	0	0	2276	8202
R-HSA-1300644	Interaction With The Zona Pellucida	1.00000000000251	2.50810012712157e-12	10	0	0	2276	8202
R-HSA-1433617	Regulation of signaling by NODAL	1.00000000000251	2.50810012712157e-12	10	0	0	2276	8202
R-HSA-5621480	Dectin-2 family	1.00000000000251	2.50810012712157e-12	10	0	0	2276	8202
R-HSA-170660	Adenylate cyclase activating pathway	1.00000000000251	2.50810012712157e-12	10	0	0	2276	8202
R-HSA-190377	FGFR2b ligand binding and activation	1.00000000000251	2.50810012712157e-12	10	0	0	2276	8202
R-HSA-194002	Glucocorticoid biosynthesis	1.00000000000303	3.03292509210267e-12	9	0	0	2276	8202
R-HSA-425561	Sodium/Calcium exchangers	1.00000000000303	3.03292509210267e-12	9	0	0	2276	8202
R-HSA-156587	Amino Acid conjugation	1.00000000000303	3.03292509210267e-12	9	0	0	2276	8202
R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide	1.00000000000303	3.03292509210267e-12	9	0	0	2276	8202
R-HSA-1480926	O2/CO2 exchange in erythrocytes	1.00000000000303	3.03292509210267e-12	9	0	0	2276	8202
R-HSA-189085	Digestion of dietary carbohydrate	1.00000000000303	3.03292509210267e-12	9	0	0	2276	8202
R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors	1.00000000000303	3.03292509210267e-12	9	0	0	2276	8202
R-HSA-159424	Conjugation of carboxylic acids	1.00000000000303	3.03292509210267e-12	9	0	0	2276	8202
R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen	1.00000000000303	3.03292509210267e-12	9	0	0	2276	8202
R-HSA-1296052	Ca2+ activated K+ channels	1.00000000000303	3.03292509210267e-12	9	0	0	2276	8202
R-HSA-1462054	Alpha-defensins	1.00000000000303	3.03292509210267e-12	9	0	0	2276	8202
R-HSA-159782	Removal of aminoterminal propeptides from gamma-carboxylated proteins	1.00000000000303	3.03292509210267e-12	9	0	0	2276	8202
R-HSA-444473	Formyl peptide receptors bind formyl peptides and many other ligands	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-164944	Nef and signal transduction	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-159763	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-5619115	Disorders of transmembrane transporters	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-1483115	Hydrolysis of LPC	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-195399	VEGF binds to VEGFR leading to receptor dimerization	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-400451	Free fatty acids regulate insulin secretion	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-434316	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-5688849	Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-804914	Transport of fatty acids	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-5688890	Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-444821	Relaxin receptors	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-177128	Conjugation of salicylate with glycine	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-389397	Orexin and neuropeptides FF and QRFP bind to their respective receptors	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-194313	VEGF ligand-receptor interactions	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-5632681	Ligand-receptor interactions	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-210747	Regulation of gene expression in early pancreatic precursor cells	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-192456	Digestion of dietary lipid	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-1236973	Cross-presentation of particulate exogenous antigens (phagosomes)	1.00000000000417	4.16637386347956e-12	8	0	0	2276	8202
R-HSA-879518	Transport of organic anions	1.00000000000484	4.84342367973125e-12	11	0	0	2276	8202
R-HSA-2022923	Dermatan sulfate biosynthesis	1.00000000000484	4.84342367973125e-12	11	0	0	2276	8202
R-HSA-71288	Creatine metabolism	1.00000000000484	4.84342367973125e-12	11	0	0	2276	8202
R-HSA-2485179	Activation of the phototransduction cascade	1.00000000000484	4.84342367973125e-12	11	0	0	2276	8202
R-HSA-5602498	MyD88 deficiency (TLR2/4)	1.00000000000484	4.84342367973125e-12	11	0	0	2276	8202
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	1.00000000000484	4.84342367973125e-12	11	0	0	2276	8202
R-HSA-211999	CYP2E1 reactions	1.00000000000484	4.84342367973125e-12	11	0	0	2276	8202
R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	1.00000000000484	4.84342367973125e-12	11	0	0	2276	8202
R-HSA-1839122	Signaling by activated point mutants of FGFR1	1.00000000000484	4.84342367973125e-12	11	0	0	2276	8202
R-HSA-5668599	RHO GTPases Activate NADPH Oxidases	1.00000000000484	4.84342367973125e-12	11	0	0	2276	8202
R-HSA-418038	Nucleotide-like (purinergic) receptors	1.00000000000911	9.11093504524317e-12	16	0	0	2276	8202
R-HSA-190242	FGFR1 ligand binding and activation	1.00000000000911	9.11093504524317e-12	16	0	0	2276	8202
R-HSA-181431	Acetylcholine Binding And Downstream Events	1.00000000000923	9.22998847936341e-12	14	0	0	2276	8202
R-HSA-629602	Activation of Nicotinic Acetylcholine Receptors	1.00000000000923	9.22998847936341e-12	14	0	0	2276	8202
R-HSA-622327	Postsynaptic nicotinic acetylcholine receptors	1.00000000000923	9.22998847936341e-12	14	0	0	2276	8202
R-HSA-190322	FGFR4 ligand binding and activation	1.00000000000923	9.22998847936341e-12	14	0	0	2276	8202
R-HSA-190861	Gap junction assembly	1.00000000001016	1.01632964045141e-11	19	0	0	2276	8202
R-HSA-1181150	Signaling by NODAL	1.00000000001016	1.01632964045141e-11	19	0	0	2276	8202
R-HSA-174577	Activation of C3 and C5	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-3656534	Loss of Function of TGFBR1 in Cancer	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-3656225	Defective CHST6 causes MCDC1	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-196791	Vitamin D (calciferol) metabolism	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-3595177	Defective CHSY1 causes TPBS	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-166665	Terminal pathway of complement	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-190371	FGFR3b ligand binding and activation	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-3656244	Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-429593	Inositol transporters	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-3595174	Defective CHST14 causes EDS, musculocontractural type	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-74182	Ketone body metabolism	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-5619102	SLC transporter disorders	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-420597	Nectin/Necl  trans heterodimerization	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-3595172	Defective CHST3 causes SEDCJD	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-3656532	TGFBR1 KD Mutants in Cancer	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-3656243	Defective ST3GAL3 causes MCT12 and EIEE15	1.00000000001214	1.21356927870568e-11	7	0	0	2276	8202
R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	1.00000000001243	1.24263825874591e-11	15	0	0	2276	8202
R-HSA-211935	Fatty acids	1.00000000001243	1.24263825874591e-11	15	0	0	2276	8202
R-HSA-159418	Recycling of bile acids and salts	1.00000000001243	1.24263825874591e-11	15	0	0	2276	8202
R-HSA-194223	HDL-mediated lipid transport	1.00000000001243	1.24263825874591e-11	15	0	0	2276	8202
R-HSA-166663	Initial triggering of complement	1.00000000001344	1.34366337851917e-11	20	0	0	2276	8202
R-HSA-190241	FGFR2 ligand binding and activation	1.00000000001344	1.34366337851917e-11	20	0	0	2276	8202
R-HSA-140875	Common Pathway of Fibrin Clot Formation	1.00000000001557	1.55724907506662e-11	22	0	0	2276	8202
R-HSA-2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	1.00000000002136	2.13647958355741e-11	23	0	0	2276	8202
R-HSA-1839130	Signaling by activated point mutants of FGFR3	1.00000000002379	2.37949023250822e-11	12	0	0	2276	8202
R-HSA-2022857	Keratan sulfate degradation	1.00000000002379	2.37949023250822e-11	12	0	0	2276	8202
R-HSA-190373	FGFR1c ligand binding and activation	1.00000000002379	2.37949023250822e-11	12	0	0	2276	8202
R-HSA-71384	Ethanol oxidation	1.00000000002379	2.37949023250822e-11	12	0	0	2276	8202
R-HSA-2168880	Scavenging of heme from plasma	1.00000000002379	2.37949023250822e-11	12	0	0	2276	8202
R-HSA-211958	Miscellaneous substrates	1.00000000002379	2.37949023250822e-11	12	0	0	2276	8202
R-HSA-190239	FGFR3 ligand binding and activation	1.00000000002379	2.37949023250822e-11	12	0	0	2276	8202
R-HSA-417957	P2Y receptors	1.00000000002379	2.37949023250822e-11	12	0	0	2276	8202
R-HSA-2033514	FGFR3 mutant receptor activation	1.00000000002379	2.37949023250822e-11	12	0	0	2276	8202
R-HSA-166786	Creation of C4 and C2 activators	1.00000000002379	2.37949023250822e-11	12	0	0	2276	8202
R-HSA-622323	Presynaptic nicotinic acetylcholine receptors	1.00000000002379	2.37949023250822e-11	12	0	0	2276	8202
R-HSA-211979	Eicosanoids	1.00000000002379	2.37949023250822e-11	12	0	0	2276	8202
R-HSA-190372	FGFR3c ligand binding and activation	1.00000000002379	2.37949023250822e-11	12	0	0	2276	8202
R-HSA-2029481	FCGR activation	1.00000000002535	2.53475677720377e-11	13	0	0	2276	8202
R-HSA-190375	FGFR2c ligand binding and activation	1.00000000002535	2.53475677720377e-11	13	0	0	2276	8202
R-HSA-1592389	Activation of Matrix Metalloproteinases	1.00000000002831	2.83120314853517e-11	31	0	0	2276	8202
R-HSA-2033519	Activated point mutants of FGFR2	1.00000000002987	2.986629679445e-11	17	0	0	2276	8202
R-HSA-1839126	FGFR2 mutant receptor activation	1.00000000002987	2.986629679445e-11	17	0	0	2276	8202
R-HSA-1461973	Defensins	1.00000000003115	3.11530529271772e-11	51	0	0	2276	8202
R-HSA-1461957	Beta defensins	1.00000000003132	3.13151691563705e-11	42	0	0	2276	8202
R-HSA-211981	Xenobiotics	1.00000000003995	3.99545601189384e-11	21	0	0	2276	8202
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	1.00000000003995	3.99545601189384e-11	21	0	0	2276	8202
R-HSA-1296072	Voltage gated Potassium channels	1.00000000004088	4.08767134198356e-11	43	0	0	2276	8202