TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols SMP00092 Rosuvastatin Action Pathway 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00508 Cholesteryl ester storage disease 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00510 Mevalonic aciduria 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00387 CHILD Syndrome 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00095 Alendronate Action Pathway 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00107 Zoledronate Action Pathway 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00389 Smith-Lemli-Opitz Syndrome (SLOS) 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00112 Risedronate Action Pathway 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,9453,3988,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,GGPS1,LIPA,PMVK,HMGCR,FDFT1,EBP SMP00119 Fluvastatin Action Pathway 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00079 Ibandronate Action Pathway 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00209 Hypercholesterolemia 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00388 Chondrodysplasia Punctata II- X Linked Dominant (CDPX2) 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00386 Desmosterolosis 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00511 Wolman disease 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00023 Steroid Biosynthesis 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00099 Lovastatin Action Pathway 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00509 Hyper-IgD syndrome 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 1595,6646,3157,3422,6307,4597,2224,1718,9453,10654,3988,3156,2222,10682 CYP51A1,SOAT1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,GGPS1,PMVK,LIPA,HMGCR,FDFT1,EBP SMP00131 Atorvastatin Action Pathway 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00082 Simvastatin Action Pathway 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,9453,3988,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,GGPS1,LIPA,PMVK,HMGCR,FDFT1,EBP SMP00117 Pamidronate Action Pathway 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00319 Lysosomal Acid Lipase Deficiency (Wolman Disease) 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00111 Cerivastatin Action Pathway 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00089 Pravastatin Action Pathway 9.30569524729484e-05 -9.28229886006435 21 14 0.0549019607843137 255 978 6646,1595,3157,3422,6307,4597,2224,1718,3988,9453,10654,3156,2222,10682 SOAT1,CYP51A1,HMGCS1,IDI1,MSMO1,MVD,FDPS,DHCR24,LIPA,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00548 Mitochondrial complex II deficiency 0.000501867173859539 -7.59717506718899 21 13 0.0509803921568627 255 978 5160,50,5091,8802,6391,4191,2271,1431,4967,3420,1738,1743,6392 PDHA1,ACO2,PC,SUCLG1,SDHC,MDH2,FH,CS,OGDH,IDH3B,DLD,DLST,SDHD SMP00057 Citric Acid Cycle 0.000501867173859539 -7.59717506718899 21 13 0.0509803921568627 255 978 5160,50,5091,8802,6391,4191,2271,1431,4967,3420,1738,1743,6392 PDHA1,ACO2,PC,SUCLG1,SDHC,MDH2,FH,CS,OGDH,IDH3B,DLD,DLST,SDHD SMP00551 Pyruvate dehydrogenase deficiency (E2) 0.000501867173859539 -7.59717506718899 21 13 0.0509803921568627 255 978 5160,50,5091,8802,6391,4191,2271,1431,4967,3420,1738,1743,6392 PDHA1,ACO2,PC,SUCLG1,SDHC,MDH2,FH,CS,OGDH,IDH3B,DLD,DLST,SDHD SMP00546 Congenital lactic acidosis 0.000501867173859539 -7.59717506718899 21 13 0.0509803921568627 255 978 5160,50,5091,8802,6391,4191,2271,1431,4967,3420,1738,1743,6392 PDHA1,ACO2,PC,SUCLG1,SDHC,MDH2,FH,CS,OGDH,IDH3B,DLD,DLST,SDHD SMP00549 2-ketoglutarate dehydrogenase complex deficiency 0.000501867173859539 -7.59717506718899 21 13 0.0509803921568627 255 978 5160,50,5091,8802,6391,4191,2271,1431,4967,3420,1738,1743,6392 PDHA1,ACO2,PC,SUCLG1,SDHC,MDH2,FH,CS,OGDH,IDH3B,DLD,DLST,SDHD SMP00547 Fumarase deficiency 0.000501867173859539 -7.59717506718899 21 13 0.0509803921568627 255 978 5160,50,5091,8802,6391,4191,2271,1431,4967,3420,1738,1743,6392 PDHA1,ACO2,PC,SUCLG1,SDHC,MDH2,FH,CS,OGDH,IDH3B,DLD,DLST,SDHD SMP00550 Pyruvate dehydrogenase deficiency (E3) 0.000501867173859539 -7.59717506718899 21 13 0.0509803921568627 255 978 5160,50,5091,8802,6391,4191,2271,1431,4967,3420,1738,1743,6392 PDHA1,ACO2,PC,SUCLG1,SDHC,MDH2,FH,CS,OGDH,IDH3B,DLD,DLST,SDHD SMP00355 Mitochondrial Electron Transport Chain 0.000647878835526289 -7.34180686130787 19 12 0.0470588235294118 255 978 2597,2542,517,6391,2820,4694,54205,498,506,514,513,6392 GAPDH,SLC37A4,ATP5G2,SDHC,GPD2,NDUFA1,CYCS,ATP5A1,ATP5B,ATP5E,ATP5D,SDHD SMP00654 Warburg Effect 0.0116677896332418 -4.45092325651511 45 19 0.0745098039215686 255 978 5160,2597,25796,8802,6391,2271,4967,1743,5226,6392,50,5091,5230,1431,6566,5224,3420,1738,22934 PDHA1,GAPDH,PGLS,SUCLG1,SDHC,FH,OGDH,DLST,PGD,SDHD,ACO2,PC,PGK1,CS,SLC16A1,PGAM2,IDH3B,DLD,RPIA SMP00037 Lysine Degradation 0.0294869202818956 -3.52380849423318 13 7 0.0274509803921569 255 978 55526,501,6542,3033,2639,1743,1738 DHTKD1,ALDH7A1,SLC7A2,HADH,GCDH,DLST,DLD SMP00186 Glutaric Aciduria Type I 0.0294869202818956 -3.52380849423318 13 7 0.0274509803921569 255 978 55526,501,6542,3033,2639,1743,1738 DHTKD1,ALDH7A1,SLC7A2,HADH,GCDH,DLST,DLD SMP00528 Hyperlysinemia II or Saccharopinuria 0.0294869202818956 -3.52380849423318 13 7 0.0274509803921569 255 978 55526,501,6542,3033,2639,1743,1738 DHTKD1,ALDH7A1,SLC7A2,HADH,GCDH,DLST,DLD SMP00527 Hyperlysinemia I- Familial 0.0294869202818956 -3.52380849423318 13 7 0.0274509803921569 255 978 55526,501,6542,3033,2639,1743,1738 DHTKD1,ALDH7A1,SLC7A2,HADH,GCDH,DLST,DLD SMP00239 Saccharopinuria/Hyperlysinemia II 0.0294869202818956 -3.52380849423318 13 7 0.0274509803921569 255 978 55526,501,6542,3033,2639,1743,1738 DHTKD1,ALDH7A1,SLC7A2,HADH,GCDH,DLST,DLD SMP00719 2-aminoadipic 2-oxoadipic aciduria 0.0294869202818956 -3.52380849423318 13 7 0.0274509803921569 255 978 55526,501,6542,3033,2639,1743,1738 DHTKD1,ALDH7A1,SLC7A2,HADH,GCDH,DLST,DLD SMP00571 Pyridoxine dependency with seizures 0.0294869202818956 -3.52380849423318 13 7 0.0274509803921569 255 978 55526,501,6542,3033,2639,1743,1738 DHTKD1,ALDH7A1,SLC7A2,HADH,GCDH,DLST,DLD SMP00123 Betaine Metabolism 0.0319964573516137 -3.44213009007304 8 5 0.0196078431372549 255 978 27430,501,55349,10400,4548 MAT2B,ALDH7A1,CHDH,PEMT,MTR SMP00452 Threonine and 2-Oxobutanoate Degradation 0.056919043071929 -2.8661253177091 9 5 0.0196078431372549 255 978 4594,594,1738,593,1629 MUT,BCKDHB,DLD,BCKDHA,DBT SMP00203 Molybdenum Cofactor Deficiency 0.0741666148587609 -2.60144116457776 37 14 0.0549019607843137 255 978 159,2618,5198,10201,2987,5471,10606,84896,6240,3614,6241,11164,5144,1716 ADSS,GART,PFAS,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,NUDT5,PDE4D,DGUOK SMP00167 Adenylosuccinate Lyase Deficiency 0.0741666148587609 -2.60144116457776 37 14 0.0549019607843137 255 978 159,2618,5198,10201,2987,5471,10606,84896,6240,3614,6241,11164,5144,1716 ADSS,GART,PFAS,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,NUDT5,PDE4D,DGUOK SMP00365 Gout or Kelley-Seegmiller Syndrome 0.0741666148587609 -2.60144116457776 37 14 0.0549019607843137 255 978 159,2618,5198,10201,2987,5471,10606,84896,6240,3614,6241,11164,5144,1716 ADSS,GART,PFAS,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,NUDT5,PDE4D,DGUOK SMP00220 Xanthine Dehydrogenase Deficiency (Xanthinuria) 0.0741666148587609 -2.60144116457776 37 14 0.0549019607843137 255 978 159,2618,5198,10201,2987,5471,10606,84896,6240,3614,6241,11164,5144,1716 ADSS,GART,PFAS,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,NUDT5,PDE4D,DGUOK SMP00537 Myoadenylate deaminase deficiency 0.0741666148587609 -2.60144116457776 37 14 0.0549019607843137 255 978 159,2618,5198,10201,2987,5471,10606,84896,6240,3614,6241,11164,5144,1716 ADSS,GART,PFAS,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,NUDT5,PDE4D,DGUOK SMP00050 Purine Metabolism 0.0741666148587609 -2.60144116457776 37 14 0.0549019607843137 255 978 159,2618,5198,10201,2987,5471,10606,84896,6240,3614,6241,11164,5144,1716 ADSS,GART,PFAS,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,NUDT5,PDE4D,DGUOK SMP00144 Adenosine Deaminase Deficiency 0.0741666148587609 -2.60144116457776 37 14 0.0549019607843137 255 978 159,2618,5198,10201,2987,5471,10606,84896,6240,3614,6241,11164,5144,1716 ADSS,GART,PFAS,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,NUDT5,PDE4D,DGUOK SMP00536 Mitochondrial DNA depletion syndrome 0.0741666148587609 -2.60144116457776 37 14 0.0549019607843137 255 978 159,2618,5198,10201,2987,5471,10606,84896,6240,3614,6241,11164,5144,1716 ADSS,GART,PFAS,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,NUDT5,PDE4D,DGUOK SMP00535 Adenine phosphoribosyltransferase deficiency (APRT) 0.0741666148587609 -2.60144116457776 37 14 0.0549019607843137 255 978 159,2618,5198,10201,2987,5471,10606,84896,6240,3614,6241,11164,5144,1716 ADSS,GART,PFAS,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,NUDT5,PDE4D,DGUOK SMP00512 Xanthinuria type I 0.0741666148587609 -2.60144116457776 37 14 0.0549019607843137 255 978 159,2618,5198,10201,2987,5471,10606,84896,6240,3614,6241,11164,5144,1716 ADSS,GART,PFAS,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,NUDT5,PDE4D,DGUOK SMP00513 Xanthinuria type II 0.0741666148587609 -2.60144116457776 37 14 0.0549019607843137 255 978 159,2618,5198,10201,2987,5471,10606,84896,6240,3614,6241,11164,5144,1716 ADSS,GART,PFAS,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,NUDT5,PDE4D,DGUOK SMP00210 Purine Nucleoside Phosphorylase Deficiency 0.0741666148587609 -2.60144116457776 37 14 0.0549019607843137 255 978 159,2618,5198,10201,2987,5471,10606,84896,6240,3614,6241,11164,5144,1716 ADSS,GART,PFAS,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,NUDT5,PDE4D,DGUOK SMP00364 Lesch-Nyhan Syndrome (LNS) 0.0741666148587609 -2.60144116457776 37 14 0.0549019607843137 255 978 159,2618,5198,10201,2987,5471,10606,84896,6240,3614,6241,11164,5144,1716 ADSS,GART,PFAS,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,NUDT5,PDE4D,DGUOK SMP00168 AICA-Ribosiduria 0.0741666148587609 -2.60144116457776 37 14 0.0549019607843137 255 978 159,2618,10201,2987,5198,5471,10606,84896,6240,3614,6241,5144,11164,1716 ADSS,GART,NME6,GUK1,PFAS,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,PDE4D,NUDT5,DGUOK SMP00320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine 0.0907851713466154 -2.39925931787223 38 14 0.0549019607843137 255 978 572,5058,5170,3725,673,5609,998,5608,3551,1147,10411,2002,4791,1386 BAD,PAK1,PDPK1,JUN,BRAF,MAP2K7,CDC42,MAP2K6,IKBKB,CHUK,RAPGEF3,ELK1,NFKB2,ATF2 SMP00321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine 0.0907851713466154 -2.39925931787223 38 14 0.0549019607843137 255 978 572,5058,5170,3725,673,5609,998,5608,3551,1147,10411,2002,4791,1386 BAD,PAK1,PDPK1,JUN,BRAF,MAP2K7,CDC42,MAP2K6,IKBKB,CHUK,RAPGEF3,ELK1,NFKB2,ATF2 SMP00025 Phospholipid Biosynthesis 0.111363573635354 -2.19495499207621 26 10 0.0392156862745098 255 978 10400,23659,2820,10554,162466,10434,57678,5130,1040,1119 PEMT,PLA2G15,GPD2,AGPAT1,PHOSPHO1,LYPLA1,GPAM,PCYT1A,CDS1,CHKA SMP00055 Alanine Metabolism 0.114614425986498 -2.16618160141534 5 3 0.0117647058823529 255 978 5091,16,57505 PC,AARS,AARS2 SMP00070 Riboflavin Metabolism 0.114614425986498 -2.16618160141534 5 3 0.0117647058823529 255 978 52,80308,55312 ACP1,FLAD1,RFK SMP00352 Primary Hyperoxaluria Type I 0.114614425986498 -2.16618160141534 5 3 0.0117647058823529 255 978 5091,16,57505 PC,AARS,AARS2 SMP00350 Pyruvate Carboxylase Deficiency 0.114614425986498 -2.16618160141534 5 3 0.0117647058823529 255 978 5091,16,57505 PC,AARS,AARS2 SMP00313 Lactic Acidemia 0.114614425986498 -2.16618160141534 5 3 0.0117647058823529 255 978 5091,16,57505 PC,AARS,AARS2 SMP00018 Alpha Linolenic Acid and Linoleic Acid Metabolism 0.114614425986498 -2.16618160141534 5 3 0.0117647058823529 255 978 3992,60481,9415 FADS1,ELOVL5,FADS2 SMP00015 Glutathione Metabolism 0.131355619287585 -2.02984698274104 11 5 0.0196078431372549 255 978 840,79017,119391,2729,2937 CASP7,GGCT,GSTO2,GCLC,GSS SMP00500 5-oxoprolinase deficiency 0.131355619287585 -2.02984698274104 11 5 0.0196078431372549 255 978 840,79017,119391,2729,2937 CASP7,GGCT,GSTO2,GCLC,GSS SMP00187 Glycerol Kinase Deficiency 0.131355619287585 -2.02984698274104 11 5 0.0196078431372549 255 978 231,2710,57678,2820,10554 AKR1B1,GK,GPAM,GPD2,AGPAT1 SMP00337 Glutathione Synthetase Deficiency 0.131355619287585 -2.02984698274104 11 5 0.0196078431372549 255 978 840,79017,119391,2729,2937 CASP7,GGCT,GSTO2,GCLC,GSS SMP00143 5-Oxoprolinuria 0.131355619287585 -2.02984698274104 11 5 0.0196078431372549 255 978 840,119391,79017,2729,2937 CASP7,GSTO2,GGCT,GCLC,GSS SMP00501 Gamma-glutamyl-transpeptidase deficiency 0.131355619287585 -2.02984698274104 11 5 0.0196078431372549 255 978 840,119391,79017,2729,2937 CASP7,GSTO2,GGCT,GCLC,GSS SMP00530 Familial lipoprotein lipase deficiency 0.131355619287585 -2.02984698274104 11 5 0.0196078431372549 255 978 231,2710,57678,2820,10554 AKR1B1,GK,GPAM,GPD2,AGPAT1 SMP00529 D-glyceric acidura 0.131355619287585 -2.02984698274104 11 5 0.0196078431372549 255 978 231,2710,57678,2820,10554 AKR1B1,GK,GPAM,GPD2,AGPAT1 SMP00039 Glycerolipid Metabolism 0.131355619287585 -2.02984698274104 11 5 0.0196078431372549 255 978 231,2710,57678,2820,10554 AKR1B1,GK,GPAM,GPD2,AGPAT1 SMP00183 Gamma-Glutamyltransferase Deficiency 0.131355619287585 -2.02984698274104 11 5 0.0196078431372549 255 978 840,79017,119391,2729,2937 CASP7,GGCT,GSTO2,GCLC,GSS SMP00428 Mercaptopurine Action Pathway 0.135367443797087 -1.99976239204549 47 16 0.0627450980392157 255 978 10201,2987,10257,5471,84896,6240,6241,2030,159,2618,5198,10606,3614,5144,11164,1716 NME6,GUK1,ABCC4,PPAT,ATAD1,RRM1,RRM2,SLC29A1,ADSS,GART,PFAS,PAICS,IMPDH1,PDE4D,NUDT5,DGUOK SMP00430 Thioguanine Action Pathway 0.135367443797087 -1.99976239204549 47 16 0.0627450980392157 255 978 159,2618,5198,10257,10201,2987,5471,10606,84896,6240,3614,6241,2030,11164,5144,1716 ADSS,GART,PFAS,ABCC4,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,SLC29A1,NUDT5,PDE4D,DGUOK SMP00427 Azathioprine Action Pathway 0.135367443797087 -1.99976239204549 47 16 0.0627450980392157 255 978 159,2618,5198,10257,10201,2987,5471,10606,84896,6240,3614,6241,2030,11164,5144,1716 ADSS,GART,PFAS,ABCC4,NME6,GUK1,PPAT,PAICS,ATAD1,RRM1,IMPDH1,RRM2,SLC29A1,NUDT5,PDE4D,DGUOK SMP00725 Fructose intolerance- hereditary 0.162820587588006 -1.81510637402323 18 7 0.0274509803921569 255 978 29925,5372,231,197258,4351,6652,226 GMPPB,PMM1,AKR1B1,FUK,MPI,SORD,ALDOA SMP00561 Fructosuria 0.162820587588006 -1.81510637402323 18 7 0.0274509803921569 255 978 29925,5372,231,197258,4351,6652,226 GMPPB,PMM1,AKR1B1,FUK,MPI,SORD,ALDOA SMP00064 Fructose and Mannose Degradation 0.162820587588006 -1.81510637402323 18 7 0.0274509803921569 255 978 29925,5372,231,197258,4351,6652,226 GMPPB,PMM1,AKR1B1,FUK,MPI,SORD,ALDOA SMP00464 Vitamin K Metabolism 0.168215030895833 -1.78251217220269 3 2 0.00784313725490196 255 978 2677,1728 GGCX,NQO1 SMP00124 Glycerol Phosphate Shuttle 0.168215030895833 -1.78251217220269 3 2 0.00784313725490196 255 978 2597,2820 GAPDH,GPD2 SMP00459 Pyruvaldehyde Degradation 0.168215030895833 -1.78251217220269 3 2 0.00784313725490196 255 978 2739,3029 GLO1,HAGH SMP00499 Beta-mercaptolactate-cysteine disulfiduria 0.185424263944944 -1.68510876092412 9 4 0.0156862745098039 255 978 2805,1497,2729,1491 GOT1,CTNS,GCLC,CTH SMP00013 Cysteine Metabolism 0.185424263944944 -1.68510876092412 9 4 0.0156862745098039 255 978 2805,1497,2729,1491 GOT1,CTNS,GCLC,CTH SMP00722 Cystinosis- ocular nonnephropathic 0.185424263944944 -1.68510876092412 9 4 0.0156862745098039 255 978 2805,1497,2729,1491 GOT1,CTNS,GCLC,CTH SMP00466 Transfer of Acetyl Groups into Mitochondria 0.185424263944944 -1.68510876092412 9 4 0.0156862745098039 255 978 5160,5091,47,1431 PDHA1,PC,ACLY,CS SMP00445 Spermidine and Spermine Biosynthesis 0.186186817478613 -1.68100471428984 6 3 0.0117647058823529 255 978 27430,262,6611 MAT2B,AMD1,SMS SMP00478 Nucleotide Excision Repair 0.186186817478613 -1.68100471428984 6 3 0.0117647058823529 255 978 3978,2068,25885 LIG1,ERCC2,POLR1A SMP00128 Gluconeogenesis 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 5224,2597,5091,2542,669,4191,226,5105 PGAM2,GAPDH,PC,SLC37A4,BPGM,MDH2,ALDOA,PCK1 SMP00060 Pyruvate Metabolism 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 5160,231,2739,5091,3029,97,1738,5105 PDHA1,AKR1B1,GLO1,PC,HAGH,ACYP1,DLD,PCK1 SMP00136 2-Hydroxyglutric Aciduria (D And L Form) 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 8659,55191,124454,1373,5471,2729,55577,2937 ALDH4A1,NADSYN1,EARS2,CPS1,PPAT,GCLC,NAGK,GSS SMP00581 Glycogenosis- Type IA. Von gierke disease 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 5224,2597,5091,2542,669,4191,226,5105 PGAM2,GAPDH,PC,SLC37A4,BPGM,MDH2,ALDOA,PCK1 SMP00567 Succinic semialdehyde dehydrogenase deficiency 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 8659,55191,1373,124454,5471,2729,55577,2937 ALDH4A1,NADSYN1,CPS1,EARS2,PPAT,GCLC,NAGK,GSS SMP00339 Hyperinsulinism-Hyperammonemia Syndrome 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 8659,55191,124454,1373,5471,2729,55577,2937 ALDH4A1,NADSYN1,EARS2,CPS1,PPAT,GCLC,NAGK,GSS SMP00574 Glycogenosis- Type IC 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 5224,2597,5091,2542,669,4191,226,5105 PGAM2,GAPDH,PC,SLC37A4,BPGM,MDH2,ALDOA,PCK1 SMP00334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 5160,5091,97,5105,231,2739,1738,3029 PDHA1,PC,ACYP1,PCK1,AKR1B1,GLO1,DLD,HAGH SMP00243 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 8659,55191,124454,1373,5471,2729,55577,2937 ALDH4A1,NADSYN1,EARS2,CPS1,PPAT,GCLC,NAGK,GSS SMP00563 Triosephosphate isomerase 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 5224,2597,5091,2542,669,4191,226,5105 PGAM2,GAPDH,PC,SLC37A4,BPGM,MDH2,ALDOA,PCK1 SMP00562 Fructose-1-6-diphosphatase deficiency 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 5224,2597,5091,2542,669,4191,226,5105 PGAM2,GAPDH,PC,SLC37A4,BPGM,MDH2,ALDOA,PCK1 SMP00196 Leigh Syndrome 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 5160,231,2739,5091,3029,97,1738,5105 PDHA1,AKR1B1,GLO1,PC,HAGH,ACYP1,DLD,PCK1 SMP00212 Pyruvate Dehydrogenase Complex Deficiency 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 5160,5091,97,5105,231,2739,1738,3029 PDHA1,PC,ACYP1,PCK1,AKR1B1,GLO1,DLD,HAGH SMP00385 Homocarnosinosis 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 8659,55191,124454,1373,5471,2729,55577,2937 ALDH4A1,NADSYN1,EARS2,CPS1,PPAT,GCLC,NAGK,GSS SMP00374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 5224,2597,5091,2542,669,4191,226,5105 PGAM2,GAPDH,PC,SLC37A4,BPGM,MDH2,ALDOA,PCK1 SMP00558 Primary hyperoxaluria II- PH2 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 5160,5091,97,5105,231,2739,1738,3029 PDHA1,PC,ACYP1,PCK1,AKR1B1,GLO1,DLD,HAGH SMP00560 Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1) 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 5224,2597,5091,2542,669,4191,226,5105 PGAM2,GAPDH,PC,SLC37A4,BPGM,MDH2,ALDOA,PCK1 SMP00072 Glutamate Metabolism 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 8659,55191,124454,1373,5471,2729,55577,2937 ALDH4A1,NADSYN1,EARS2,CPS1,PPAT,GCLC,NAGK,GSS SMP00573 Glycogenosis- Type IB 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 5224,2597,5091,2542,669,4191,226,5105 PGAM2,GAPDH,PC,SLC37A4,BPGM,MDH2,ALDOA,PCK1 SMP00559 Pyruvate kinase deficiency 0.190445756580625 -1.65838786732111 22 8 0.0313725490196078 255 978 5160,5091,97,5105,231,2739,1738,3029 PDHA1,PC,ACYP1,PCK1,AKR1B1,GLO1,DLD,HAGH SMP00340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 0.203386589016381 -1.59264673158084 19 7 0.0274509803921569 255 978 27430,55349,6470,4548,262,4507,1491 MAT2B,CHDH,SHMT1,MTR,AMD1,MTAP,CTH SMP00214 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency 0.203386589016381 -1.59264673158084 19 7 0.0274509803921569 255 978 27430,55349,6470,4548,262,4507,1491 MAT2B,CHDH,SHMT1,MTR,AMD1,MTAP,CTH SMP00221 Methionine Adenosyltransferase Deficiency 0.203386589016381 -1.59264673158084 19 7 0.0274509803921569 255 978 27430,55349,6470,4548,262,4507,1491 MAT2B,CHDH,SHMT1,MTR,AMD1,MTAP,CTH SMP00177 Cystathionine Beta-Synthase Deficiency 0.203386589016381 -1.59264673158084 19 7 0.0274509803921569 255 978 27430,55349,6470,4548,262,4507,1491 MAT2B,CHDH,SHMT1,MTR,AMD1,MTAP,CTH SMP00341 Hypermethioninemia 0.203386589016381 -1.59264673158084 19 7 0.0274509803921569 255 978 27430,55349,6470,4548,262,4507,1491 MAT2B,CHDH,SHMT1,MTR,AMD1,MTAP,CTH SMP00033 Methionine Metabolism 0.203386589016381 -1.59264673158084 19 7 0.0274509803921569 255 978 27430,55349,6470,4548,262,4507,1491 MAT2B,CHDH,SHMT1,MTR,AMD1,MTAP,CTH SMP00222 Glycine N-methyltransferase Deficiency 0.203386589016381 -1.59264673158084 19 7 0.0274509803921569 255 978 27430,55349,6470,4548,262,4507,1491 MAT2B,CHDH,SHMT1,MTR,AMD1,MTAP,CTH SMP00570 Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism- cblG complementation type 0.203386589016381 -1.59264673158084 19 7 0.0274509803921569 255 978 27430,55349,6470,4548,262,4507,1491 MAT2B,CHDH,SHMT1,MTR,AMD1,MTAP,CTH SMP00632 Prednisolone Metabolism Pathway 0.260736196319118 -1.34424612487601 1 1 0.00392156862745098 255 978 3320 HSP90AA1 SMP00263 Cilostazol Action Pathway 0.260736196319118 -1.34424612487601 1 1 0.00392156862745098 255 978 5144 PDE4D SMP00264 Dipyridamole (Antiplatelet) Action Pathway 0.260736196319118 -1.34424612487601 1 1 0.00392156862745098 255 978 5144 PDE4D SMP00441 Prednisolone Action Pathway 0.260736196319118 -1.34424612487601 1 1 0.00392156862745098 255 978 3320 HSP90AA1 SMP00682 Leucine Stimulation on Insulin Signaling 0.265711696914384 -1.32534340417299 7 3 0.0117647058823529 255 978 6198,2475,6009 RPS6KB1,MTOR,RHEB SMP00041 Sulfate/Sulfite Metabolism 0.265711696914384 -1.32534340417299 7 3 0.0117647058823529 255 978 50515,6821,6820 CHST11,SUOX,SULT2B1 SMP00532 Sulfite oxidase deficiency 0.265711696914384 -1.32534340417299 7 3 0.0117647058823529 255 978 50515,6821,6820 CHST11,SUOX,SULT2B1 SMP00076 Thiamine Metabolism 0.279768426589589 -1.27379306590001 4 2 0.00784313725490196 255 978 10560,27010 SLC19A2,TPK1 SMP00629 Adefovir Dipivoxil Metabolism Pathway 0.279768426589589 -1.27379306590001 4 2 0.00784313725490196 255 978 204,4831 AK2,NME2 SMP00630 Tenofovir Metabolism Pathway 0.279768426589589 -1.27379306590001 4 2 0.00784313725490196 255 978 204,4831 AK2,NME2 SMP00011 Inositol Metabolism 0.293882251519551 -1.22457609690256 21 7 0.0274509803921569 255 978 5289,64768,51477,200576,55697,253430,30849 PIK3C3,IPPK,ISYNA1,PIKFYVE,VAC14,IPMK,PIK3R4 SMP00370 Tyrosinemia Type 3 (TYRO3) 0.31607337048628 -1.15178090726285 11 4 0.0156862745098039 255 978 2954,2805,2193,10056 GSTZ1,GOT1,FARSA,FARSB SMP00008 Phenylalanine and Tyrosine Metabolism 0.31607337048628 -1.15178090726285 11 4 0.0156862745098039 255 978 2954,2805,2193,10056 GSTZ1,GOT1,FARSA,FARSB SMP00009 Ammonia Recycling 0.31607337048628 -1.15178090726285 11 4 0.0156862745098039 255 978 1373,440,1738,2653 CPS1,ASNS,DLD,GCSH SMP00206 Phenylketonuria 0.31607337048628 -1.15178090726285 11 4 0.0156862745098039 255 978 2954,2805,2193,10056 GSTZ1,GOT1,FARSA,FARSB SMP00369 Tyrosinemia Type 2 (or Richner-Hanhart syndrome) 0.31607337048628 -1.15178090726285 11 4 0.0156862745098039 255 978 2954,2805,2193,10056 GSTZ1,GOT1,FARSA,FARSB SMP00442 Etoposide Action Pathway 0.31921962923881 -1.14187592018818 18 6 0.0235294117647059 255 978 7153,5743,5479,23753,10961,3309 TOP2A,PTGS2,PPIB,SDF2L1,ERP29,HSPA5 SMP00601 Etoposide Metabolism Pathway 0.31921962923881 -1.14187592018818 18 6 0.0235294117647059 255 978 7153,5743,5479,23753,10961,3309 TOP2A,PTGS2,PPIB,SDF2L1,ERP29,HSPA5 SMP00487 Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency 0.348152215596361 -1.05511549370069 8 3 0.0117647058823529 255 978 5805,231,2644 PTS,AKR1B1,GCHFR SMP00496 Galactosemia III 0.348152215596361 -1.05511549370069 8 3 0.0117647058823529 255 978 7360,7358,2582 UGP2,UGDH,GALE SMP00005 Pterine Biosynthesis 0.348152215596361 -1.05511549370069 8 3 0.0117647058823529 255 978 5805,231,2644 PTS,AKR1B1,GCHFR SMP00488 Hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency (ptps) 0.348152215596361 -1.05511549370069 8 3 0.0117647058823529 255 978 5805,231,2644 PTS,AKR1B1,GCHFR SMP00495 Galactosemia II (GALK) 0.348152215596361 -1.05511549370069 8 3 0.0117647058823529 255 978 7360,7358,2582 UGP2,UGDH,GALE SMP00010 Nucleotide Sugars Metabolism 0.348152215596361 -1.05511549370069 8 3 0.0117647058823529 255 978 7360,7358,2582 UGP2,UGDH,GALE SMP00490 Segawa syndrome 0.348152215596361 -1.05511549370069 8 3 0.0117647058823529 255 978 5805,231,2644 PTS,AKR1B1,GCHFR SMP00491 Sepiapterin reductase deficiency 0.348152215596361 -1.05511549370069 8 3 0.0117647058823529 255 978 5805,231,2644 PTS,AKR1B1,GCHFR SMP00486 Dopa-responsive dystonia 0.348152215596361 -1.05511549370069 8 3 0.0117647058823529 255 978 5805,231,2644 PTS,AKR1B1,GCHFR SMP00489 Hyperphenylalaninemia due to dhpr-deficiency 0.348152215596361 -1.05511549370069 8 3 0.0117647058823529 255 978 5805,231,2644 PTS,AKR1B1,GCHFR SMP00518 Glucose-6-phosphate dehydrogenase deficiency 0.34881754487691 -1.05320628753313 15 5 0.0196078431372549 255 978 64080,25796,226,22934,5226 RBKS,PGLS,ALDOA,RPIA,PGD SMP00031 Pentose Phosphate Pathway 0.34881754487691 -1.05320628753313 15 5 0.0196078431372549 255 978 64080,25796,226,22934,5226 RBKS,PGLS,ALDOA,RPIA,PGD SMP00519 Ribose-5-phosphate isomerase deficiency 0.34881754487691 -1.05320628753313 15 5 0.0196078431372549 255 978 64080,25796,226,22934,5226 RBKS,PGLS,ALDOA,RPIA,PGD SMP00520 Transaldolase deficiency 0.34881754487691 -1.05320628753313 15 5 0.0196078431372549 255 978 64080,25796,226,22934,5226 RBKS,PGLS,ALDOA,RPIA,PGD SMP00004 Glycine and Serine Metabolism 0.360770962002345 -1.01951197628768 26 8 0.0313725490196078 255 978 4128,2617,6470,29968,1738,23464,5723,1491 MAOA,GARS,SHMT1,PSAT1,DLD,GCAT,PSPH,CTH SMP00484 Dimethylglycine Dehydrogenase Deficiency 0.360770962002345 -1.01951197628768 26 8 0.0313725490196078 255 978 4128,2617,6470,29968,1738,23464,5723,1491 MAOA,GARS,SHMT1,PSAT1,DLD,GCAT,PSPH,CTH SMP00244 Sarcosinemia 0.360770962002345 -1.01951197628768 26 8 0.0313725490196078 255 978 4128,2617,6470,29968,1738,23464,5723,1491 MAOA,GARS,SHMT1,PSAT1,DLD,GCAT,PSPH,CTH SMP00242 Dimethylglycine Dehydrogenase Deficiency 0.360770962002345 -1.01951197628768 26 8 0.0313725490196078 255 978 4128,2617,6470,29968,1738,23464,5723,1491 MAOA,GARS,SHMT1,PSAT1,DLD,GCAT,PSPH,CTH SMP00223 Non Ketotic Hyperglycinemia 0.360770962002345 -1.01951197628768 26 8 0.0313725490196078 255 978 4128,2617,6470,29968,1738,23464,5723,1491 MAOA,GARS,SHMT1,PSAT1,DLD,GCAT,PSPH,CTH SMP00179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) 0.360770962002345 -1.01951197628768 26 8 0.0313725490196078 255 978 4128,2617,6470,29968,1738,23464,5723,1491 MAOA,GARS,SHMT1,PSAT1,DLD,GCAT,PSPH,CTH SMP00721 3-Phosphoglycerate dehydrogenase deficiency 0.360770962002345 -1.01951197628768 26 8 0.0313725490196078 255 978 4128,2617,6470,29968,1738,23464,5723,1491 MAOA,GARS,SHMT1,PSAT1,DLD,GCAT,PSPH,CTH SMP00485 Hyperglycinemia- non-ketotic 0.360770962002345 -1.01951197628768 26 8 0.0313725490196078 255 978 4128,2617,6470,29968,1738,23464,5723,1491 MAOA,GARS,SHMT1,PSAT1,DLD,GCAT,PSPH,CTH SMP00522 3-hydroxyisobutyric aciduria 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00524 Isovaleric acidemia 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00523 Isobutyryl-coa dehydrogenase deficiency 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00237 3-Methylcrotonyl Coa Carboxylase Deficiency Type I 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00238 Isovaleric Aciduria 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00199 Maple Syrup Urine Disease 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00521 3-hydroxyisobutyric acid dehydrogenase deficiency 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00236 Propionic Acidemia 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00200 Methylmalonic Aciduria 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00384 Methylmalonate Semialdehyde Dehydrogenase Deficiency 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00140 3-Methylglutaconic Aciduria Type III 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00139 3-Methylglutaconic Aciduria Type I 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00032 Valine- Leucine and Isoleucine Degradation 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00173 Beta-Ketothiolase Deficiency 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00141 3-Methylglutaconic Aciduria Type IV 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00137 2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00138 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency 0.376387853803898 -0.977135141175485 30 9 0.0352941176470588 255 978 4594,4329,594,593,56922,1738,1629,64087,11112 MUT,ALDH6A1,BCKDHB,BCKDHA,MCCC1,DLD,DBT,MCCC2,HIBADH SMP00219 UMP Synthase Deiciency (Orotic Aciduria) 0.391306590354946 -0.938263907702268 23 7 0.0274509803921569 255 978 1723,6241,1890,7083,10201,54963,1854 DHODH,RRM2,TYMP,TK1,NME6,UCKL1,DUT SMP00202 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) 0.391306590354946 -0.938263907702268 23 7 0.0274509803921569 255 978 1723,6241,1890,7083,10201,54963,1854 DHODH,RRM2,TYMP,TK1,NME6,UCKL1,DUT SMP00172 Beta Ureidopropionase Deficiency 0.391306590354946 -0.938263907702268 23 7 0.0274509803921569 255 978 6241,1723,1890,7083,10201,54963,1854 RRM2,DHODH,TYMP,TK1,NME6,UCKL1,DUT SMP00046 Pyrimidine Metabolism 0.391306590354946 -0.938263907702268 23 7 0.0274509803921569 255 978 1723,6241,1890,7083,10201,54963,1854 DHODH,RRM2,TYMP,TK1,NME6,UCKL1,DUT SMP00178 Dihydropyrimidinase Deficiency 0.391306590354946 -0.938263907702268 23 7 0.0274509803921569 255 978 6241,1723,1890,7083,10201,54963,1854 RRM2,DHODH,TYMP,TK1,NME6,UCKL1,DUT SMP00363 Ornithine Aminotransferase Deficiency (OAT Deficiency) 0.426397279171473 -0.852383787080801 20 6 0.0235294117647059 255 978 8659,2058,5625,2805,1373,29920 ALDH4A1,EPRS,PRODH,GOT1,CPS1,PYCR2 SMP00506 Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome] 0.426397279171473 -0.852383787080801 20 6 0.0235294117647059 255 978 8659,2058,5625,2805,1373,29920 ALDH4A1,EPRS,PRODH,GOT1,CPS1,PYCR2 SMP00507 L-arginine:glycine amidinotransferase deficiency 0.426397279171473 -0.852383787080801 20 6 0.0235294117647059 255 978 8659,2058,5625,2805,1373,29920 ALDH4A1,EPRS,PRODH,GOT1,CPS1,PYCR2 SMP00505 Hyperornithinemia with gyrate atrophy (HOGA) 0.426397279171473 -0.852383787080801 20 6 0.0235294117647059 255 978 8659,2058,5625,2805,1373,29920 ALDH4A1,EPRS,PRODH,GOT1,CPS1,PYCR2 SMP00362 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) 0.426397279171473 -0.852383787080801 20 6 0.0235294117647059 255 978 8659,2058,5625,2805,1373,29920 ALDH4A1,EPRS,PRODH,GOT1,CPS1,PYCR2 SMP00504 Creatine deficiency- guanidinoacetate methyltransferase deficiency 0.426397279171473 -0.852383787080801 20 6 0.0235294117647059 255 978 8659,2058,5625,2805,1373,29920 ALDH4A1,EPRS,PRODH,GOT1,CPS1,PYCR2 SMP00207 Prolidase Deficiency (PD) 0.426397279171473 -0.852383787080801 20 6 0.0235294117647059 255 978 8659,2058,5625,2805,1373,29920 ALDH4A1,EPRS,PRODH,GOT1,CPS1,PYCR2 SMP00360 Hyperprolinemia Type II 0.426397279171473 -0.852383787080801 20 6 0.0235294117647059 255 978 8659,2058,5625,2805,1373,29920 ALDH4A1,EPRS,PRODH,GOT1,CPS1,PYCR2 SMP00188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) 0.426397279171473 -0.852383787080801 20 6 0.0235294117647059 255 978 8659,2058,5625,2805,1373,29920 ALDH4A1,EPRS,PRODH,GOT1,CPS1,PYCR2 SMP00208 Prolinemia Type II 0.426397279171473 -0.852383787080801 20 6 0.0235294117647059 255 978 8659,2058,5625,2805,1373,29920 ALDH4A1,EPRS,PRODH,GOT1,CPS1,PYCR2 SMP00361 Hyperprolinemia Type I 0.426397279171473 -0.852383787080801 20 6 0.0235294117647059 255 978 8659,2058,5625,2805,1373,29920 ALDH4A1,EPRS,PRODH,GOT1,CPS1,PYCR2 SMP00020 Arginine and Proline Metabolism 0.426397279171473 -0.852383787080801 20 6 0.0235294117647059 255 978 8659,2058,5625,2805,1373,29920 ALDH4A1,EPRS,PRODH,GOT1,CPS1,PYCR2 SMP00554 Glycogenosis- Type IV. Amylopectinosis 0.451948028716789 -0.794188086475764 13 4 0.0156862745098039 255 978 283209,7360,2990,7358 PGM2L1,UGP2,GUSB,UGDH SMP00603 Gemcitabine Metabolism Pathway 0.451948028716789 -0.794188086475764 13 4 0.0156862745098039 255 978 6241,30833,2030,6240 RRM2,NT5C,SLC29A1,RRM1 SMP00553 Glycogenosis- Type III. Cori disease 0.451948028716789 -0.794188086475764 13 4 0.0156862745098039 255 978 283209,7360,2990,7358 PGM2L1,UGP2,GUSB,UGDH SMP00446 Gemcitabine Action Pathway 0.451948028716789 -0.794188086475764 13 4 0.0156862745098039 255 978 6241,30833,2030,6240 RRM2,NT5C,SLC29A1,RRM1 SMP00455 Homocysteine Degradation 0.453686319074722 -0.790349246889143 2 1 0.00392156862745098 255 978 1491 CTH SMP00515 Homocystinuria- cystathionine beta-synthase deficiency 0.453686319074722 -0.790349246889143 2 1 0.00392156862745098 255 978 1491 CTH SMP00514 Gamma-cystathionase deficiency (CTH) 0.453686319074722 -0.790349246889143 2 1 0.00392156862745098 255 978 1491 CTH SMP00650 Doxorubicin Metabolism Pathway 0.467485920722564 -0.760386046808362 17 5 0.0196078431372549 255 978 1728,4720,10928,374291,10327 NQO1,NDUFS2,RALBP1,NDUFS7,AKR1A1 SMP00582 Joubert syndrome 0.479403290233031 -0.735213093774218 21 6 0.0235294117647059 255 978 5289,8394,200576,8867,55697,30849 PIK3C3,PIP5K1A,PIKFYVE,SYNJ1,VAC14,PIK3R4 SMP00463 Phosphatidylinositol Phosphate Metabolism 0.479403290233031 -0.735213093774218 21 6 0.0235294117647059 255 978 5289,8394,200576,8867,55697,30849 PIK3C3,PIP5K1A,PIKFYVE,SYNJ1,VAC14,PIK3R4 SMP00437 Vincristine Action Pathway 0.506921725259137 -0.679398675359054 10 3 0.0117647058823529 255 978 10928,89845,7157 RALBP1,ABCC10,TP53 SMP00438 Vindesine Action Pathway 0.506921725259137 -0.679398675359054 10 3 0.0117647058823529 255 978 10928,89845,7157 RALBP1,ABCC10,TP53 SMP00648 Sorafenib Metabolism Pathway 0.516863331637115 -0.65997678828441 14 4 0.0156862745098039 255 978 5479,23753,10961,3309 PPIB,SDF2L1,ERP29,HSPA5 SMP00044 Histidine Metabolism 0.516863331637115 -0.65997678828441 14 4 0.0156862745098039 255 978 4128,23438,144193,10196 MAOA,HARS2,AMDHD1,PRMT3 SMP00191 Histidinemia 0.516863331637115 -0.65997678828441 14 4 0.0156862745098039 255 978 4128,23438,144193,10196 MAOA,HARS2,AMDHD1,PRMT3 SMP00462 Inositol Phosphate Metabolism 0.516863331637115 -0.65997678828441 14 4 0.0156862745098039 255 978 64768,51477,9807,253430 IPPK,ISYNA1,IP6K1,IPMK SMP00622 Morphine Metabolism Pathway 0.577970890460168 -0.548231774103655 15 4 0.0156862745098039 255 978 5479,23753,10961,3309 PPIB,SDF2L1,ERP29,HSPA5 SMP00345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease 0.577970890460168 -0.548231774103655 15 4 0.0156862745098039 255 978 3145,210,5498,2990 HMBS,ALAD,PPOX,GUSB SMP00609 Mercaptopurine Metabolism Pathway 0.577970890460168 -0.548231774103655 15 4 0.0156862745098039 255 978 3614,2030,10257,5471 IMPDH1,SLC29A1,ABCC4,PPAT SMP00344 Acute Intermittent Porphyria 0.577970890460168 -0.548231774103655 15 4 0.0156862745098039 255 978 3145,210,5498,2990 HMBS,ALAD,PPOX,GUSB SMP00040 Glycolysis 0.577970890460168 -0.548231774103655 15 4 0.0156862745098039 255 978 5224,2597,669,226 PGAM2,GAPDH,BPGM,ALDOA SMP00024 Porphyrin Metabolism 0.577970890460168 -0.548231774103655 15 4 0.0156862745098039 255 978 3145,210,5498,2990 HMBS,ALAD,PPOX,GUSB SMP00531 Glycogenosis- Type VII. Tarui disease 0.577970890460168 -0.548231774103655 15 4 0.0156862745098039 255 978 5224,2597,669,226 PGAM2,GAPDH,BPGM,ALDOA SMP00342 Hereditary Coproporphyria (HCP) 0.577970890460168 -0.548231774103655 15 4 0.0156862745098039 255 978 3145,210,5498,2990 HMBS,ALAD,PPOX,GUSB SMP00346 Porphyria Variegata (PV) 0.577970890460168 -0.548231774103655 15 4 0.0156862745098039 255 978 3145,210,5498,2990 HMBS,ALAD,PPOX,GUSB SMP00572 Fanconi-bickel syndrome 0.577970890460168 -0.548231774103655 15 4 0.0156862745098039 255 978 5224,2597,669,226 PGAM2,GAPDH,BPGM,ALDOA SMP00436 Vinblastine Action Pathway 0.578489858299882 -0.547334263530803 11 3 0.0117647058823529 255 978 10928,89845,7157 RALBP1,ABCC10,TP53 SMP00391 Insulin Signalling 0.578489858299882 -0.547334263530803 11 3 0.0117647058823529 255 978 5170,6517,5894 PDPK1,SLC2A4,RAF1 SMP00439 Vinorelbine Action Pathway 0.578489858299882 -0.547334263530803 11 3 0.0117647058823529 255 978 10928,89845,7157 RALBP1,ABCC10,TP53 SMP00029 Selenoamino Acid Metabolism 0.578489858299882 -0.547334263530803 11 3 0.0117647058823529 255 978 27430,51540,1491 MAT2B,SCLY,CTH SMP00054 Fatty Acid Elongation In Mitochondria 0.582113845687595 -0.541089239232994 7 2 0.00784313725490196 255 978 51102,3032 MECR,HADHB SMP00544 Long-chain-3-hydroxyacyl-coa dehydrogenase deficiency (LCHAD) 0.582113845687595 -0.541089239232994 7 2 0.00784313725490196 255 978 51102,3032 MECR,HADHB SMP00564 Multiple carboxylase deficiency- neonatal or early onset form 0.59642196317212 -0.516806870525291 3 1 0.00392156862745098 255 978 686 BTD SMP00174 Biotinidase Deficiency 0.59642196317212 -0.516806870525291 3 1 0.00392156862745098 255 978 686 BTD SMP00066 Biotin Metabolism 0.59642196317212 -0.516806870525291 3 1 0.00392156862745098 255 978 686 BTD SMP00555 Glycogenosis- Type VI. Hers disease 0.634446204430285 -0.455002779613906 16 4 0.0156862745098039 255 978 283209,7360,2990,7358 PGM2L1,UGP2,GUSB,UGDH SMP00058 Starch and Sucrose Metabolism 0.634446204430285 -0.455002779613906 16 4 0.0156862745098039 255 978 283209,7360,2990,7358 PGM2L1,UGP2,GUSB,UGDH SMP00557 Sucrase-isomaltase deficiency 0.634446204430285 -0.455002779613906 16 4 0.0156862745098039 255 978 283209,7360,2990,7358 PGM2L1,UGP2,GUSB,UGDH SMP00556 Mucopolysaccharidosis VI. Sly syndrome 0.634446204430285 -0.455002779613906 16 4 0.0156862745098039 255 978 283209,7360,2990,7358 PGM2L1,UGP2,GUSB,UGDH SMP00552 Glycogen synthetase deficiency 0.634446204430285 -0.455002779613906 16 4 0.0156862745098039 255 978 283209,7360,2990,7358 PGM2L1,UGP2,GUSB,UGDH SMP00543 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 0.643166793421678 -0.441351189593021 12 3 0.0117647058823529 255 978 8836,10797,2356 GGH,MTHFD2,FPGS SMP00053 Folate Metabolism 0.643166793421678 -0.441351189593021 12 3 0.0117647058823529 255 978 8836,10797,2356 GGH,MTHFD2,FPGS SMP00432 Methotrexate Action Pathway 0.643166793421678 -0.441351189593021 12 3 0.0117647058823529 255 978 8836,10797,2356 GGH,MTHFD2,FPGS SMP00724 Folate malabsorption- hereditary 0.643166793421678 -0.441351189593021 12 3 0.0117647058823529 255 978 8836,10797,2356 GGH,MTHFD2,FPGS SMP00481 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids 0.660101055718733 -0.415362340957176 8 2 0.00784313725490196 255 978 3033,3032 HADH,HADHB SMP00525 Fabry disease 0.676426633346271 -0.390931287590564 21 5 0.0196078431372549 255 978 10558,56848,9517,10825,2629 SPTLC1,SPHK2,SPTLC2,NEU3,GBA SMP00526 Krabbe disease 0.676426633346271 -0.390931287590564 21 5 0.0196078431372549 255 978 10558,56848,9517,10825,2629 SPTLC1,SPHK2,SPTLC2,NEU3,GBA SMP00349 Gaucher Disease 0.676426633346271 -0.390931287590564 21 5 0.0196078431372549 255 978 10558,56848,9517,10825,2629 SPTLC1,SPHK2,SPTLC2,NEU3,GBA SMP00034 Sphingolipid Metabolism 0.676426633346271 -0.390931287590564 21 5 0.0196078431372549 255 978 10558,9517,56848,10825,2629 SPTLC1,SPTLC2,SPHK2,NEU3,GBA SMP00347 Metachromatic Leukodystrophy (MLD) 0.676426633346271 -0.390931287590564 21 5 0.0196078431372549 255 978 10558,56848,9517,10825,2629 SPTLC1,SPHK2,SPTLC2,NEU3,GBA SMP00348 Globoid Cell Leukodystrophy 0.676426633346271 -0.390931287590564 21 5 0.0196078431372549 255 978 10558,56848,9517,10825,2629 SPTLC1,SPHK2,SPTLC2,NEU3,GBA SMP00218 Tyrosinemia Type I 0.68581859941735 -0.377142118560871 17 4 0.0156862745098039 255 978 4282,4128,2954,2805 MIF,MAOA,GSTZ1,GOT1 SMP00390 Tay-Sachs Disease 0.68581859941735 -0.377142118560871 17 4 0.0156862745098039 255 978 26503,6675,55577,10020 SLC17A5,UAP1,NAGK,GNE SMP00045 Amino Sugar Metabolism 0.68581859941735 -0.377142118560871 17 4 0.0156862745098039 255 978 26503,6675,55577,10020 SLC17A5,UAP1,NAGK,GNE SMP00498 Dopamine beta-hydroxylase deficiency 0.68581859941735 -0.377142118560871 17 4 0.0156862745098039 255 978 4128,4282,2954,2805 MAOA,MIF,GSTZ1,GOT1 SMP00533 Monoamine oxidase-a deficiency (MAO-A) 0.68581859941735 -0.377142118560871 17 4 0.0156862745098039 255 978 4128,4282,2954,2805 MAOA,MIF,GSTZ1,GOT1 SMP00240 Salla Disease/Infantile Sialic Acid Storage Disease 0.68581859941735 -0.377142118560871 17 4 0.0156862745098039 255 978 26503,6675,55577,10020 SLC17A5,UAP1,NAGK,GNE SMP00534 G(M2)-Gangliosidosis: Variant B- Tay-sachs disease 0.68581859941735 -0.377142118560871 17 4 0.0156862745098039 255 978 26503,6675,55577,10020 SLC17A5,UAP1,NAGK,GNE SMP00190 Hawkinsinuria 0.68581859941735 -0.377142118560871 17 4 0.0156862745098039 255 978 4128,4282,2954,2805 MAOA,MIF,GSTZ1,GOT1 SMP00006 Tyrosine Metabolism 0.68581859941735 -0.377142118560871 17 4 0.0156862745098039 255 978 4128,4282,2954,2805 MAOA,MIF,GSTZ1,GOT1 SMP00216 Sialuria or French Type Sialuria 0.68581859941735 -0.377142118560871 17 4 0.0156862745098039 255 978 26503,6675,55577,10020 SLC17A5,UAP1,NAGK,GNE SMP00217 Sialuria or French Type Sialuria 0.68581859941735 -0.377142118560871 17 4 0.0156862745098039 255 978 26503,6675,55577,10020 SLC17A5,UAP1,NAGK,GNE SMP00169 Alkaptonuria 0.68581859941735 -0.377142118560871 17 4 0.0156862745098039 255 978 4128,4282,2954,2805 MAOA,MIF,GSTZ1,GOT1 SMP00043 Galactose Metabolism 0.700532422835438 -0.355914629000777 13 3 0.0117647058823529 255 978 231,7360,2582 AKR1B1,UGP2,GALE SMP00182 Galactosemia 0.700532422835438 -0.355914629000777 13 3 0.0117647058823529 255 978 231,7360,2582 AKR1B1,UGP2,GALE SMP00602 Teniposide Metabolism Pathway 0.701973142037512 -0.353860134894052 4 1 0.00392156862745098 255 978 7153 TOP2A SMP00443 Teniposide Action Pathway 0.701973142037512 -0.353860134894052 4 1 0.00392156862745098 255 978 7153 TOP2A SMP00450 Phytanic Acid Peroxisomal Oxidation 0.701973142037512 -0.353860134894052 4 1 0.00392156862745098 255 978 224 ALDH3A2 SMP00065 Ubiquinone Biosynthesis 0.701973142037512 -0.353860134894052 4 1 0.00392156862745098 255 978 51004 COQ6 SMP00479 Plasmalogen Synthesis 0.701973142037512 -0.353860134894052 4 1 0.00392156862745098 255 978 10554 AGPAT1 SMP00451 Refsum Disease 0.701973142037512 -0.353860134894052 4 1 0.00392156862745098 255 978 224 ALDH3A2 SMP00129 Malate-Aspartate Shuttle 0.701973142037512 -0.353860134894052 4 1 0.00392156862745098 255 978 4191 MDH2 SMP00590 Ibuprofen Metabolism Pathway 0.719236733408152 -0.329564721756181 22 5 0.0196078431372549 255 978 5479,5743,23753,10961,3309 PPIB,PTGS2,SDF2L1,ERP29,HSPA5 SMP00580 GLUT-1 deficiency syndrome 0.725982445518834 -0.320229444175799 9 2 0.00784313725490196 255 978 7360,4831 UGP2,NME2 SMP00444 Lactose Synthesis 0.725982445518834 -0.320229444175799 9 2 0.00784313725490196 255 978 7360,4831 UGP2,NME2 SMP00579 Congenital disorder of glycosylation CDG-IId 0.725982445518834 -0.320229444175799 9 2 0.00784313725490196 255 978 7360,4831 UGP2,NME2 SMP00649 Lamivudine Metabolism Pathway 0.73190636569586 -0.312102688918776 18 4 0.0156862745098039 255 978 30833,10257,5230,5130 NT5C,ABCC4,PGK1,PCYT1A SMP00048 Nicotinate and Nicotinamide Metabolism 0.750623993162423 -0.286850427481115 14 3 0.0117647058823529 255 978 55191,4837,65220 NADSYN1,NNMT,NADK SMP00358 Fc Epsilon Receptor I Signaling in Mast Cells 0.770444577744899 -0.260787557055795 32 7 0.0274509803921569 255 978 3845,10451,5163,5609,5608,5894,5606 KRAS,VAV3,PDK1,MAP2K7,MAP2K6,RAF1,MAP2K3 SMP00021 Taurine and Hypotaurine Metabolism 0.779998654135676 -0.24846308476707 5 1 0.00392156862745098 255 978 84890 ADO SMP00469 Capecitabine Action Pathway 0.779998654135676 -0.24846308476707 5 1 0.00392156862745098 255 978 1890 TYMP SMP00607 Capecitabine Metabolism Pathway 0.779998654135676 -0.24846308476707 5 1 0.00392156862745098 255 978 1890 TYMP SMP00503 Hypophosphatasia 0.779998654135676 -0.24846308476707 5 1 0.00392156862745098 255 978 55163 PNPO SMP00017 Vitamin B6 Metabolism 0.779998654135676 -0.24846308476707 5 1 0.00392156862745098 255 978 55163 PNPO SMP00465 Carnitine Synthesis 0.779998654135676 -0.24846308476707 5 1 0.00392156862745098 255 978 6470 SHMT1 SMP00482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids 0.780747625585532 -0.247503324020459 10 2 0.00784313725490196 255 978 3033,3032 HADH,HADHB SMP00494 Tyrosinemia- transient 0.793787268839415 -0.230939777008933 15 3 0.0117647058823529 255 978 4282,2954,2805 MIF,GSTZ1,GOT1 SMP00433 Irinotecan Action Pathway 0.839650799716792 -0.174769188200923 21 4 0.0156862745098039 255 978 5479,23753,10961,3309 PPIB,SDF2L1,ERP29,HSPA5 SMP00600 Irinotecan Metabolism Pathway 0.839650799716792 -0.174769188200923 21 4 0.0156862745098039 255 978 5479,23753,10961,3309 PPIB,SDF2L1,ERP29,HSPA5 SMP00336 Vitamin A Deficiency 0.849081154335404 -0.163600509093694 35 7 0.0274509803921569 255 978 53630,5479,23753,8228,10961,9249,3309 BCO1,PPIB,SDF2L1,PNPLA4,ERP29,DHRS3,HSPA5 SMP00074 Retinol Metabolism 0.849081154335404 -0.163600509093694 35 7 0.0274509803921569 255 978 53630,5479,23753,8228,10961,9249,3309 BCO1,PPIB,SDF2L1,PNPLA4,ERP29,DHRS3,HSPA5 SMP00317 Familial Hypercholanemia (FHCA) 0.861573930338762 -0.148994410864708 17 3 0.0117647058823529 255 978 3295,3988,10858 HSD17B4,LIPA,CYP46A1 SMP00316 Zellweger Syndrome 0.861573930338762 -0.148994410864708 17 3 0.0117647058823529 255 978 3295,3988,10858 HSD17B4,LIPA,CYP46A1 SMP00315 Cerebrotendinous Xanthomatosis (CTX) 0.861573930338762 -0.148994410864708 17 3 0.0117647058823529 255 978 3295,3988,10858 HSD17B4,LIPA,CYP46A1 SMP00314 Congenital Bile Acid Synthesis Defect Type II 0.861573930338762 -0.148994410864708 17 3 0.0117647058823529 255 978 3295,3988,10858 HSD17B4,LIPA,CYP46A1 SMP00035 Bile Acid Biosynthesis 0.861573930338762 -0.148994410864708 17 3 0.0117647058823529 255 978 3295,3988,10858 HSD17B4,LIPA,CYP46A1 SMP00318 Congenital Bile Acid Synthesis Defect Type III 0.861573930338762 -0.148994410864708 17 3 0.0117647058823529 255 978 3295,3988,10858 HSD17B4,LIPA,CYP46A1 SMP00720 27-Hydroxylase Deficiency 0.861573930338762 -0.148994410864708 17 3 0.0117647058823529 255 978 3295,3988,10858 HSD17B4,LIPA,CYP46A1 SMP00458 Lactose Intolerance 0.862199196629994 -0.148268948437115 12 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00457 Lactose Degradation 0.862199196629994 -0.148268948437115 12 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00627 Citalopram Metabolism Pathway 0.880246054106687 -0.127553803653203 7 1 0.00392156862745098 255 978 4128 MAOA SMP00467 Trehalose Degradation 0.891593155504529 -0.114745354143531 13 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00640 Acetaminophen Metabolism Pathway 0.893489754695943 -0.11262041093307 28 5 0.0196078431372549 255 978 5479,23753,10257,10961,3309 PPIB,SDF2L1,ABCC4,ERP29,HSPA5 SMP00429 Disulfiram Action Pathway 0.908628478616553 -0.0958189827443821 24 4 0.0156862745098039 255 978 4128,4282,2954,2805 MAOA,MIF,GSTZ1,GOT1 SMP00127 Glucose-Alanine Cycle 0.911695339592809 -0.0924494021814549 8 1 0.00392156862745098 255 978 6517 SLC2A4 SMP00073 Butyrate Metabolism 0.911695339592809 -0.0924494021814549 8 1 0.00392156862745098 255 978 3033 HADH SMP00480 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids 0.911695339592809 -0.0924494021814549 8 1 0.00392156862745098 255 978 3033 HADH SMP00568 Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (SCHAD) 0.911695339592809 -0.0924494021814549 8 1 0.00392156862745098 255 978 3033 HADH SMP00644 Celecoxib Metabolism Pathway 0.911695339592809 -0.0924494021814549 8 1 0.00392156862745098 255 978 5743 PTGS2 SMP00642 Nevirapine Metabolism Pathway 0.911695339592809 -0.0924494021814549 8 1 0.00392156862745098 255 978 89845 ABCC10 SMP00185 Glutaric Aciduria Type I 0.915088015894985 -0.0887350260978357 14 2 0.00784313725490196 255 978 2639,3032 GCDH,HADHB SMP00540 Very-long-chain acyl coa dehydrogenase deficiency (VLCAD) 0.915088015894985 -0.0887350260978357 14 2 0.00784313725490196 255 978 2639,3032 GCDH,HADHB SMP00545 Trifunctional protein deficiency 0.915088015894985 -0.0887350260978357 14 2 0.00784313725490196 255 978 2639,3032 GCDH,HADHB SMP00542 Medium chain acyl-coa dehydrogenase deficiency (MCAD) 0.915088015894985 -0.0887350260978357 14 2 0.00784313725490196 255 978 2639,3032 GCDH,HADHB SMP00198 Malonic Aciduria 0.915088015894985 -0.0887350260978357 14 2 0.00784313725490196 255 978 4329,4594 ALDH6A1,MUT SMP00201 Methylmalonic Aciduria Due to Cobalamin-Related Disorders 0.915088015894985 -0.0887350260978357 14 2 0.00784313725490196 255 978 4329,4594 ALDH6A1,MUT SMP00235 Short Chain Acyl CoA Dehydrogenase Deficiency (SCAD Deficiency) 0.915088015894985 -0.0887350260978357 14 2 0.00784313725490196 255 978 2639,3032 GCDH,HADHB SMP00181 Ethylmalonic Encephalopathy 0.915088015894985 -0.0887350260978357 14 2 0.00784313725490196 255 978 2639,3032 GCDH,HADHB SMP00538 Carnitine palmitoyl transferase deficiency (I) 0.915088015894985 -0.0887350260978357 14 2 0.00784313725490196 255 978 2639,3032 GCDH,HADHB SMP00541 Carnitine palmitoyl transferase deficiency (II) 0.915088015894985 -0.0887350260978357 14 2 0.00784313725490196 255 978 2639,3032 GCDH,HADHB SMP00502 Malonyl-coa decarboxylase deficiency 0.915088015894985 -0.0887350260978357 14 2 0.00784313725490196 255 978 4329,4594 ALDH6A1,MUT SMP00051 Fatty acid Metabolism 0.915088015894985 -0.0887350260978357 14 2 0.00784313725490196 255 978 2639,3032 GCDH,HADHB SMP00016 Propanoate Metabolism 0.915088015894985 -0.0887350260978357 14 2 0.00784313725490196 255 978 4329,4594 ALDH6A1,MUT SMP00539 Long chain acyl-CoA dehydrogenase deficiency (LCAD) 0.915088015894985 -0.0887350260978357 14 2 0.00784313725490196 255 978 2639,3032 GCDH,HADHB SMP00351 GABA-Transaminase Deficiency 0.934909451354656 -0.0673055978540384 9 1 0.00392156862745098 255 978 4329 ALDH6A1 SMP00492 Ureidopropionase deficiency 0.934909451354656 -0.0673055978540384 9 1 0.00392156862745098 255 978 4329 ALDH6A1 SMP00493 Carnosinuria- carnosinemia 0.934909451354656 -0.0673055978540384 9 1 0.00392156862745098 255 978 4329 ALDH6A1 SMP00007 Beta-Alanine Metabolism 0.934909451354656 -0.0673055978540384 9 1 0.00392156862745098 255 978 4329 ALDH6A1 SMP00652 Mycophenolic Acid Metabolism Pathway 0.948491295804535 -0.0528826664498761 16 2 0.00784313725490196 255 978 3614,3615 IMPDH1,IMPDH2 SMP00635 Valproic Acid Metabolism Pathway 0.964673017812854 -0.0359660767076634 11 1 0.00392156862745098 255 978 3032 HADHB SMP00078 Chlorothiazide Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00088 Bumetanide Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,9990,476,6520,4306 ATP1B3,SLC12A6,ATP1A1,SLC3A2,NR3C2 SMP00115 Furosemide Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00105 Metolazone Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00197 Lysinuric Protein Intolerance 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00245 Glucose Transporter Defect (SGLT2) 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00090 Bendroflumethiazide Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00100 Hydrochlorothiazide Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00583 Blue diaper syndrome 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,9990,476,6520,4306 ATP1B3,SLC12A6,ATP1A1,SLC3A2,NR3C2 SMP00135 Eplerenone Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00483 Kidney Function 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00081 Methyclothiazide Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00108 Hydroflumethiazide Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00723 Cystinuria 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00134 Spironolactone Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00118 Torsemide Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00189 Hartnup Disorder 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,9990,476,6520,4306 ATP1B3,SLC12A6,ATP1A1,SLC3A2,NR3C2 SMP00133 Amiloride Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00184 Glucose Transporter Defect (SGLT2) 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00097 Ethacrynic Acid Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00091 Quinethazone Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,9990,476,6520,4306 ATP1B3,SLC12A6,ATP1A1,SLC3A2,NR3C2 SMP00585 Lysinuric protein intolerance (LPI) 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00132 Triamterene Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00103 Cyclothiazide Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00110 Indapamide Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,476,6520,9990,4306 ATP1B3,ATP1A1,SLC3A2,SLC12A6,NR3C2 SMP00193 Iminoglycinuria 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,9990,476,6520,4306 ATP1B3,SLC12A6,ATP1A1,SLC3A2,NR3C2 SMP00121 Trichlormethiazide Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,9990,476,6520,4306 ATP1B3,SLC12A6,ATP1A1,SLC3A2,NR3C2 SMP00080 Polythiazide Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,9990,476,6520,4306 ATP1B3,SLC12A6,ATP1A1,SLC3A2,NR3C2 SMP00122 Chlorthalidone Action Pathway 0.965576204523408 -0.035030252705231 34 5 0.0196078431372549 255 978 483,9990,476,6520,4306 ATP1B3,SLC12A6,ATP1A1,SLC3A2,NR3C2 SMP00406 Morphine Action Pathway 0.971162347454 -0.0292616285244082 40 6 0.0235294117647059 255 978 5479,483,476,23753,10961,3309 PPIB,ATP1B3,ATP1A1,SDF2L1,ERP29,HSPA5 SMP00068 Androgen and Estrogen Metabolism 0.973988819740065 -0.0263554541117811 12 1 0.00392156862745098 255 978 6820 SULT2B1 SMP00565 Aromatase deficiency 0.973988819740065 -0.0263554541117811 12 1 0.00392156862745098 255 978 6820 SULT2B1 SMP00356 17-Beta Hydroxysteroid Dehydrogenase III Deficiency 0.973988819740065 -0.0263554541117811 12 1 0.00392156862745098 255 978 6820 SULT2B1 SMP00063 Tryptophan Metabolism 0.976225732478438 -0.0240614360338105 19 2 0.00784313725490196 255 978 8942,7453 KYNU,WARS SMP00002 Carbamoyl Phosphate Synthetase Deficiency 0.980855125096315 -0.0193305111623011 13 1 0.00392156862745098 255 978 1373 CPS1 SMP00003 Argininosuccinic Aciduria 0.980855125096315 -0.0193305111623011 13 1 0.00392156862745098 255 978 1373 CPS1 SMP00205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) 0.980855125096315 -0.0193305111623011 13 1 0.00392156862745098 255 978 1373 CPS1 SMP00357 Argininemia 0.980855125096315 -0.0193305111623011 13 1 0.00392156862745098 255 978 1373 CPS1 SMP00001 Citrullinemia Type I 0.980855125096315 -0.0193305111623011 13 1 0.00392156862745098 255 978 1373 CPS1 SMP00059 Urea Cycle 0.980855125096315 -0.0193305111623011 13 1 0.00392156862745098 255 978 1373 CPS1 SMP00327 Phenytoin (Antiarrhythmic) Action Pathway 0.983148111506516 -0.0169954972383909 77 13 0.0509803921568627 255 978 5479,476,7169,488,1728,3775,3309,483,23753,10961,5566,5573,144245 PPIB,ATP1A1,TPM2,ATP2A2,NQO1,KCNK1,HSPA5,ATP1B3,SDF2L1,ERP29,PRKACA,PRKAR1A,ALG10B SMP00282 Streptokinase Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00268 Warfarin Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00276 Argatroban Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00288 Aprotinin Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00279 Ximelagatran Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00281 Anistreplase Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00656 Dicoumarol Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00283 Tenecteplase Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00269 Acenocoumarol Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00280 Alteplase Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00277 Bivalirudin Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00271 Phenprocoumon Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00285 Reteplase Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00278 Lepirudin Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00655 Phenindione Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00586 Coagulation 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00284 Urokinase Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00287 Tranexamic Acid Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00067 Aspartate Metabolism 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 440 ASNS SMP00270 Dicumarol Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00175 Canavan Disease 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 440 ASNS SMP00192 Hypoacetylaspartia 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 440 ASNS SMP00286 Aminocaproic Acid Action Pathway 0.985914133496902 -0.0141860138746211 14 1 0.00392156862745098 255 978 2677 GGCX SMP00275 Ardeparin Action Pathway 0.989640166656465 -0.0104138699477861 15 1 0.00392156862745098 255 978 2677 GGCX SMP00273 Fondaparinux Action Pathway 0.989640166656465 -0.0104138699477861 15 1 0.00392156862745098 255 978 2677 GGCX SMP00274 Heparin Action Pathway 0.989640166656465 -0.0104138699477861 15 1 0.00392156862745098 255 978 2677 GGCX SMP00272 Enoxaparin Action Pathway 0.989640166656465 -0.0104138699477861 15 1 0.00392156862745098 255 978 2677 GGCX SMP00306 Pindolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00323 Quinidine Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00660 Sotalol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00379 Nifedipine Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00325 Disopyramide Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00669 Practolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00667 Metipranolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00380 Nimodipine Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00381 Nisoldipine Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00659 Timolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00661 Epinephrine Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00324 Procainamide (Antiarrhythmic) Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00366 Nebivolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00377 Felodipine Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00296 Acebutolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00305 Penbutolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00663 Isoprenaline Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00658 Carteolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00657 Bopindolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00664 Arbutamine Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00588 Muscle/Heart Contraction 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00298 Atenolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00304 Oxprenolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00332 Ibutilide Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00665 Amiodarone Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00378 Isradipine Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00670 Bupranolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00303 Nadolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00297 Alprenolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00331 Flecainide Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00359 Diltiazem Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00375 Verapamil Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00382 Nitrendipine Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00662 Dobutamine Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00329 Mexiletine Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00302 Metoprolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00300 Bisoprolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00376 Amlodipine Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00301 Esmolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00299 Betaxolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00330 Tocainide Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00307 Propranolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00326 Fosphenytoin (Antiarrhythmic) Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00666 Levobunolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00668 Bevantolol Action Pathway 0.992212123228174 -0.00781836065710482 57 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00368 Labetalol Action Pathway 0.993590253812066 -0.00643037681634314 58 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00367 Carvedilol Action Pathway 0.993590253812066 -0.00643037681634314 58 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00328 Lidocaine (Antiarrhythmic) Action Pathway 0.994736757418291 -0.00527714223589837 59 8 0.0313725490196078 255 978 476,7169,488,3775,483,5566,144245,5573 ATP1A1,TPM2,ATP2A2,KCNK1,ATP1B3,PRKACA,ALG10B,PRKAR1A SMP00424 Citalopram Action Pathway 0.995794785678742 -0.00421408110154024 32 3 0.0117647058823529 255 978 4128,483,476 MAOA,ATP1B3,ATP1A1 SMP00674 Anileridine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00411 Hydrocodone Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00689 Dihydromorphine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00687 Naltrexone Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00675 Diphenoxylate Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00417 Sufentanil Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00686 Pentazocine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00404 Ropivacaine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00425 Escitalopram Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00679 3-Methylthiofentanyl Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00681 Ethylmorphine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00684 Buprenorphine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00672 Propoxyphene Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00690 Ketobemidone Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00392 Benzocaine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00410 Hydromorphone Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00399 Mepivacaine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00678 Methadyl Acetate Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00416 Remifentanil Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00671 Tramadol Action Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00393 Bupivacaine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00396 Dibucaine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00415 Fentanyl Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00673 Levorphanol Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00401 Prilocaine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00685 Alvimopan Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00400 Oxybuprocaine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00394 Chloroprocaine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00414 Carfentanil Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00397 Levobupivacaine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00676 Dezocine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00413 Alfentanil Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00395 Cocaine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00412 Oxymorphone Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00688 Naloxone Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00403 Proparacaine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00677 Levomethadyl Acetate Action Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00683 Levallorphan Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00402 Procaine Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00680 Dimethylthiambutene Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00409 Oxycodone Action Pathway 0.996386330146877 -0.00362021493061667 26 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00691 Nalbuphine Action Pathway 0.99725864509302 -0.00274511930161175 27 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00423 Desipramine Action Pathway 0.99725864509302 -0.00274511930161175 27 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00398 Lidocaine (Local Anaesthetic) Action Pathway 0.997923517999593 -0.00207864087825437 28 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00086 Ibuprofen Action Pathway 0.997954439149761 -0.00204765586731269 47 5 0.0196078431372549 255 978 5743,5479,23753,10961,3309 PTGS2,PPIB,SDF2L1,ERP29,HSPA5 SMP00405 Codeine Action Pathway 0.99842939166954 -0.00157184302871155 29 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00407 Heroin Action Pathway 0.99842939166954 -0.00157184302871155 29 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00422 Imipramine Action Pathway 0.998813651573611 -0.0011870526947433 30 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00426 Fluoxetine Action Pathway 0.999105075222583 -0.000895325461668586 31 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00431 Nicotine Action Pathway 0.999325761194265 -0.000674466206939062 32 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00408 Methadone Action Pathway 0.999325761194265 -0.000674466206939062 32 2 0.00784313725490196 255 978 483,476 ATP1B3,ATP1A1 SMP00706 Tenoxicam Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00693 Antrafenine Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00102 Bromfenac Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00699 Lumiracoxib Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00098 Ketorolac Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00106 Meloxicam Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00707 Salsalate Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00085 Ketoprofen Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00692 Antipyrine Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00353 Leukotriene C4 Synthesis Deficiency 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00700 Lornoxicam Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00701 Phenylbutazone Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00094 Sulindac Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00114 Nabumetone Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00109 Mefenamic Acid Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00113 Oxaprozin Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00702 Nepafenac Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00698 Magnesium salicylate Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00289 Diflunisal Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00708 Salicylate-sodium Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00077 Piroxicam Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00083 Acetylsalicylic Acid Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00710 Acetaminophen Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00697 Flurbiprofen Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00084 Etodolac Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00075 Arachidonic Acid Metabolism 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00696 Fenoprofen Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00703 Trisalicylate-choline Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00709 Salicylic Acid Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00093 Diclofenac Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00695 Etoricoxib Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00101 Suprofen Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00704 Tolmetin Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00694 Carprofen Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00705 Tiaprofenic Acid Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00087 Rofecoxib Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00116 Valdecoxib Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00120 Naproxen Action Pathway 0.99981556518817 -0.000184451822021525 28 1 0.00392156862745098 255 978 5743 PTGS2 SMP00104 Indomethacin Action Pathway 0.999865071385864 -0.000134937717820367 29 1 0.00392156862745098 255 978 5743 PTGS2 SMP00096 Celecoxib Action Pathway 0.99997188863245 -2.81117626814955e-05 34 1 0.00392156862745098 255 978 5743 PTGS2 SMP00612 Esomeprazole Metabolism Pathway 0.999999999993353 -6.64676647055273e-12 2 0 0 255 978 SMP00616 Rabeprazole Metabolism Pathway 0.999999999993353 -6.64676647055273e-12 2 0 0 255 978 SMP00613 Omeprazole Metabolism Pathway 0.999999999993353 -6.64676647055273e-12 2 0 0 255 978 SMP00614 Lansoprazole Metabolism Pathway 0.999999999993353 -6.64676647055273e-12 2 0 0 255 978 SMP00615 Pantoprazole Metabolism Pathway 0.999999999993353 -6.64676647055273e-12 2 0 0 255 978 SMP00456 Fatty Acid Biosynthesis 0.999999999993353 -6.64676647055273e-12 2 0 0 255 978 SMP00420 Bevacizumab Action Pathway 0.999999999998144 -1.85568227450972e-12 3 0 0 255 978 SMP00653 Rosiglitazone Metabolism Pathway 0.999999999998144 -1.85568227450972e-12 3 0 0 255 978 SMP00126 Phenylacetate Metabolism 0.999999999998144 -1.85568227450972e-12 3 0 0 255 978 SMP00619 Felodipine Metabolism Pathway 0.999999999998144 -1.85568227450972e-12 3 0 0 255 978 SMP00626 Desipramine Metabolism Pathway 0.999999999998144 -1.85568227450972e-12 3 0 0 255 978 SMP00472 Erlotinib Action Pathway 0.999999999998144 -1.85568227450972e-12 3 0 0 255 978 SMP00631 Prednisone Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00265 Abciximab Action Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00476 Trastuzumab Action Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00593 Enalapril Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00732 Temocapril Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00473 Gefitinib Action Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00261 Ticlopidine Action Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00595 Moexipril Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00475 Panitumumab Action Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00647 Thioguanine Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00474 Cetuximab Action Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00591 Benazepril Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00597 Ramipril Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00267 Tirofiban Action Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00596 Quinapril Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00617 Cimetidine Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00421 Vatalanib Action Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00592 Cilazapril Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00036 D-Arginine and D-Ornithine Metabolism 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00470 Fluorouracil Action Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00611 Ticlopidine Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00599 Trandolapril Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00594 Fosinopril Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00598 Spirapril Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00440 Prednisone Action Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00638 Levomethadyl Acetate Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00266 Eptifibatide Action Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00608 Fluorouracil Metabolism Pathway 1.00000000000047 4.74564831876023e-13 1 0 0 255 978 SMP00153 Quinapril Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00623 Heroin Metabolism Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00165 Valsartan Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00150 Lisinopril Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00633 Felbamate Metabolism Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00164 Telmisartan Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00651 Artemether Metabolism Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00170 Aromatic L-Aminoacid Decarboxylase Deficiency 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00145 Benazepril Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00620 Lidocaine (Local Anaesthetic) Metabolism Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00733 Temocapril Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00621 Codeine Metabolism Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00152 Perindopril Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00012 Catecholamine Biosynthesis 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00149 Fosinopril Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00163 Olmesartan Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00154 Ramipril Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00497 Tyrosine hydroxylase deficiency 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00148 Enalapril Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00162 Losartan Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00155 Rescinnamine Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00161 Irbesartan Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00639 Clomipramine Metabolism Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00146 Captopril Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00160 Forasartan Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00587 Angiotensin Metabolism 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00159 Eprosartan Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00147 Cilazapril Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00156 Spirapril Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00151 Moexipril Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00158 Candesartan Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00157 Trandolapril Action Pathway 1.0000000000016 1.59785639580745e-12 4 0 0 255 978 SMP00468 Degradation of Superoxides 1.00000000000453 4.53267002924196e-12 5 0 0 255 978 SMP00516 Adrenoleukodystrophy- X-linked 1.00000000000453 4.53267002924196e-12 5 0 0 255 978 SMP00454 Repaglinide Action Pathway 1.00000000000453 4.53267002924196e-12 5 0 0 255 978 SMP00641 Doxepin Metabolism Pathway 1.00000000000453 4.53267002924196e-12 5 0 0 255 978 SMP00453 Nateglinide Action Pathway 1.00000000000453 4.53267002924196e-12 5 0 0 255 978 SMP00052 Beta Oxidation of Very Long Chain Fatty Acids 1.00000000000453 4.53267002924196e-12 5 0 0 255 978 SMP00460 Glibenclamide Action Pathway 1.00000000000453 4.53267002924196e-12 5 0 0 255 978 SMP00643 Pancreas Function 1.00000000000453 4.53267002924196e-12 5 0 0 255 978 SMP00517 Carnitine-acylcarnitine translocase deficiency 1.00000000000453 4.53267002924196e-12 5 0 0 255 978 SMP00569 Succinyl CoA: 3-ketoacid CoA transferase deficiency 1.00000000000453 4.53267002924196e-12 5 0 0 255 978 SMP00071 Ketone Body Metabolism 1.00000000000453 4.53267002924196e-12 5 0 0 255 978 SMP00310 Corticotropin Activation of Cortisol Production 1.00000000000453 4.53267002924196e-12 5 0 0 255 978 SMP00461 Gliclazide Action Pathway 1.00000000000453 4.53267002924196e-12 5 0 0 255 978 SMP00646 Fluoxetine Metabolism Pathway 1.0000000000076 7.59991104336971e-12 6 0 0 255 978 SMP00636 Venlafaxine Metabolism Pathway 1.0000000000076 7.59991104336971e-12 6 0 0 255 978 SMP00343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 1.0000000000076 7.59991104336971e-12 6 0 0 255 978 SMP00628 Nicotine Metabolism Pathway 1.0000000000076 7.59991104336971e-12 6 0 0 255 978 SMP00308 Dopamine Activation of Neurological Reward System 1.0000000000076 7.59991104336971e-12 6 0 0 255 978 SMP00625 Imipramine Metabolism Pathway 1.0000000000076 7.59991104336971e-12 6 0 0 255 978 SMP00027 Pantothenate and CoA Biosynthesis 1.0000000000076 7.59991104336971e-12 6 0 0 255 978 SMP00449 Ethanol Degradation 1.00000000000956 9.56457810630425e-12 7 0 0 255 978 SMP00634 Carbamazepine Metabolism Pathway 1.00000000000956 9.56457810630425e-12 7 0 0 255 978 SMP00434 Paclitaxel Action Pathway 1.00000000000956 9.56457810630425e-12 7 0 0 255 978 SMP00322 Vasopressin Regulation of Water Homeostasis 1.00000000000956 9.56457810630425e-12 7 0 0 255 978 SMP00637 Tramadol Metabolism Pathway 1.00000000000956 9.56457810630425e-12 7 0 0 255 978 SMP00435 Docetaxel Action Pathway 1.00000000000956 9.56457810630425e-12 7 0 0 255 978 SMP00030 Oxidation of Branched Chain Fatty Acids 1.00000000001141 1.14112425665138e-11 8 0 0 255 978 SMP00605 Ifosfamide Metabolism Pathway 1.00000000001141 1.14112425665138e-11 8 0 0 255 978 SMP00028 Caffeine Metabolism 1.00000000001141 1.14112425665138e-11 8 0 0 255 978 SMP00448 Ifosfamide Action Pathway 1.00000000001141 1.14112425665138e-11 8 0 0 255 978 SMP00354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin 1.00000000001141 1.14112425665138e-11 8 0 0 255 978 SMP00228 Pantoprazole Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00232 Cimetidine Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00335 Intracellular Signalling Through Histamine H2 Receptor and Histamine 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00610 Clopidogrel Metabolism Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00225 Esomeprazole Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00716 Thyroid hormone synthesis 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00604 Cyclophosphamide Metabolism Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00230 Ranitidine Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00734 Roxatidine acetate Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00333 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00226 Omeprazole Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00735 Metiamide Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00260 Clopidogrel Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00736 Betazole Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00589 Gastric Acid Production 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00229 Rabeprazole Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00233 Nizatidine Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00309 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00227 Lansoprazole Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00231 Famotidine Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00246 Pirenzepine Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00447 Cyclophosphamide Action Pathway 1.00000000001372 1.37194369371837e-11 9 0 0 255 978 SMP00606 Tamoxifen Metabolism Pathway 1.00000000001623 1.62280253351771e-11 10 0 0 255 978 SMP00471 Tamoxifen Action Pathway 1.00000000001623 1.62280253351771e-11 10 0 0 255 978 SMP00624 Methadone Metabolism Pathway 1.00000000001623 1.62280253351771e-11 10 0 0 255 978 SMP00338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin 1.00000000001623 1.62280253351771e-11 10 0 0 255 978 SMP00566 17-alpha-hydroxylase deficiency (CYP17) 1.00000000001789 1.7885305216332e-11 11 0 0 255 978 SMP00371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH 1.00000000001789 1.7885305216332e-11 11 0 0 255 978 SMP00575 11-beta-hydroxylase deficiency (CYP11B1) 1.00000000001789 1.7885305216332e-11 11 0 0 255 978 SMP00717 Apparent mineralocorticoid excess syndrome 1.00000000001789 1.7885305216332e-11 11 0 0 255 978 SMP00372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia due to 17 Alpha-hydroxylase Deficiency 1.00000000001789 1.7885305216332e-11 11 0 0 255 978 SMP00576 21-hydroxylase deficiency (CYP21) 1.00000000001789 1.7885305216332e-11 11 0 0 255 978 SMP00577 Corticosterone methyl oxidase I deficiency (CMO I) 1.00000000001789 1.7885305216332e-11 11 0 0 255 978 SMP00578 Corticosterone methyl oxidase II deficiency - CMO II 1.00000000001789 1.7885305216332e-11 11 0 0 255 978 SMP00718 3-Beta-Hydroxysteroid Dehydrogenase Deficiency 1.00000000001789 1.7885305216332e-11 11 0 0 255 978 SMP00373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency 1.00000000001789 1.7885305216332e-11 11 0 0 255 978 SMP00130 Steroidogenesis 1.00000000001789 1.7885305216332e-11 11 0 0 255 978