TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols HUMAN_PWY-7511 protein ubiquitylation 0.000145681475157753 -8.83408799658196 28 22 0.0555555555555556 396 907 7323,7317,9039,55284,65264,55585,118424,55236,92912,9246,997,29089,55293,7336,79876,51465,51619,27338,10477,7321,54926,7327 UBE2D3,UBA1,UBA3,UBE2W,UBE2Z,UBE2Q1,UBE2J2,UBA6,UBE2Q2,UBE2L6,CDC34,UBE2T,UEVLD,UBE2V2,UBA5,UBE2J1,UBE2D4,UBE2S,UBE2E3,UBE2D1,UBE2R2,UBE2G2 HUMAN_PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis 0.00145070118397823 -6.53570826427704 14 12 0.0303030303030303 396 907 84284,1841,29922,10201,4830,50484,1854,6240,4831,6241,7298,4832 NTPCR,DTYMK,NME7,NME6,NME1,RRM2B,DUT,RRM1,NME2,RRM2,TYMS,NME3 HUMAN_PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP 0.00145070118397823 -6.53570826427704 14 12 0.0303030303030303 396 907 84284,1841,29922,10201,4830,50484,6240,4831,6241,7298,1635,4832 NTPCR,DTYMK,NME7,NME6,NME1,RRM2B,RRM1,NME2,RRM2,TYMS,DCTD,NME3 HUMAN_PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis 0.00417011446756496 -5.47981179329279 20 15 0.0378787878787879 396 907 84284,1841,29922,10201,4830,50484,1854,56474,6240,4831,6241,7298,7372,51727,4832 NTPCR,DTYMK,NME7,NME6,NME1,RRM2B,DUT,CTPS2,RRM1,NME2,RRM2,TYMS,UMPS,CMPK1,NME3 HUMAN_PWY66-409 superpathway of purine nucleotide salvage 0.00419363050578182 -5.47418845105546 38 25 0.0631313131313131 396 907 4860,10201,122481,6240,6241,353,521,3615,506,9551,122622,4832,3251,203,29922,4830,50484,27109,509,10476,4831,3614,8833,498,132 PNP,NME6,AK7,RRM1,RRM2,APRT,ATP5I,IMPDH2,ATP5B,ATP5J2,ADSSL1,NME3,HPRT1,AK1,NME7,NME1,RRM2B,ATP5S,ATP5C1,ATP5H,NME2,IMPDH1,GMPS,ATP5A1,ADK HUMAN_PWY-841 purine nucleotides de novo biosynthesis 0.00659086485987359 -5.02207070085813 37 24 0.0606060606060606 396 907 10201,5471,122481,6240,6241,521,3615,506,9551,122622,4832,203,29922,4830,27109,50484,509,10606,10476,471,4831,3614,8833,498 NME6,PPAT,AK7,RRM1,RRM2,ATP5I,IMPDH2,ATP5B,ATP5J2,ADSSL1,NME3,AK1,NME7,NME1,ATP5S,RRM2B,ATP5C1,PAICS,ATP5H,ATIC,NME2,IMPDH1,GMPS,ATP5A1 META_PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP 0.00703596516034373 -4.95672040374732 9 8 0.0202020202020202 396 907 84284,1841,4830,6240,4831,6241,7298,1635 NTPCR,DTYMK,NME1,RRM1,NME2,RRM2,TYMS,DCTD META_PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis I 0.00703596516034373 -4.95672040374732 9 8 0.0202020202020202 396 907 7298,6241,84284,1841,4830,1854,6240,4831 TYMS,RRM2,NTPCR,DTYMK,NME1,DUT,RRM1,NME2 HUMAN_PWY-7228 guanosine nucleotides de novo biosynthesis 0.00828804164923377 -4.79294156823225 14 11 0.0277777777777778 396 907 29922,10201,4830,50484,6240,4831,3614,6241,8833,3615,4832 NME7,NME6,NME1,RRM2B,RRM1,NME2,IMPDH1,RRM2,GMPS,IMPDH2,NME3 META_PWY66-5 superpathway of cholesterol biosynthesis 0.0101172970566428 -4.59350874006205 23 16 0.0404040404040404 396 907 50814,10654,9453,3930,10682,4047,3422,3157,39,6307,2224,38,6309,1717,3156,2222 NSDHL,PMVK,GGPS1,LBR,EBP,LSS,IDI1,HMGCS1,ACAT2,MSMO1,FDPS,ACAT1,SC5D,DHCR7,HMGCR,FDFT1 HUMAN_PWY66-5 superpathway of cholesterol biosynthesis 0.0113123140520061 -4.48186340748292 25 17 0.0429292929292929 396 907 50814,7108,10654,9453,3930,10682,4047,3422,3157,39,6307,2224,38,6309,1717,2222,3156 NSDHL,TM7SF2,PMVK,GGPS1,LBR,EBP,LSS,IDI1,HMGCS1,ACAT2,MSMO1,FDPS,ACAT1,SC5D,DHCR7,FDFT1,HMGCR META_PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis 0.0153581857128539 -4.17610667589179 13 10 0.0252525252525253 396 907 84284,1841,4830,1854,56474,6240,4831,6241,7298,51727 NTPCR,DTYMK,NME1,DUT,CTPS2,RRM1,NME2,RRM2,TYMS,CMPK1 HUMAN_PWY-7227 adenosine deoxyribonucleotides de novo biosynthesis 0.0217761032604396 -3.82694209114637 10 8 0.0202020202020202 396 907 6241,29922,10201,4830,50484,4832,6240,4831 RRM2,NME7,NME6,NME1,RRM2B,NME3,RRM1,NME2 HUMAN_PWY-7226 guanosine deoxyribonucleotides de novo biosynthesis 0.0217761032604396 -3.82694209114637 10 8 0.0202020202020202 396 907 6241,29922,10201,4830,50484,4832,6240,4831 RRM2,NME7,NME6,NME1,RRM2B,NME3,RRM1,NME2 HUMAN_PWY-5667 CDP-diacylglycerol biosynthesis 0.0248885869878244 -3.69334593449037 19 13 0.0328282828282828 396 907 2710,8760,55326,56895,84803,254531,10554,56894,10162,57678,129642,253558,137964 GK,CDS2,AGPAT5,AGPAT4,GPAT3,LPCAT4,AGPAT1,AGPAT3,LPCAT3,GPAM,MBOAT2,LCLAT1,GPAT4 HUMAN_ILEUDEG-PWY isoleucine degradation 0.0279217094513965 -3.57835077619303 12 9 0.0227272727272727 396 907 38,39,36,594,593,1629,1892,587,3028 ACAT1,ACAT2,ACADSB,BCKDHB,BCKDHA,DBT,ECHS1,BCAT2,HSD17B10 HUMAN_TRIGLSYN-PWY triacylglycerol biosynthesis 0.0308030257463492 -3.48014235530987 25 16 0.0404040404040404 396 907 56895,84803,8612,10554,56894,10162,253558,137964,8611,55326,64748,254531,84649,57678,8694,129642 AGPAT4,GPAT3,PLPP2,AGPAT1,AGPAT3,LPCAT3,LCLAT1,GPAT4,PLPP1,AGPAT5,PLPPR2,LPCAT4,DGAT2,GPAM,DGAT1,MBOAT2 META_FAO-PWY fatty acid beta-oxidation I 0.033033545871971 -3.41023169226928 14 10 0.0252525252525253 396 907 2180,1962,11001,2181,3032,10449,1892,3028,6342,30 ACSL1,EHHADH,SLC27A2,ACSL3,HADHB,ACAA2,ECHS1,HSD17B10,SCP2,ACAA1 HUMAN_PWY-5177 glutaryl-CoA degradation 0.0360270381420746 -3.323485562928 4 4 0.0101010101010101 396 907 38,39,2639,1892 ACAT1,ACAT2,GCDH,ECHS1 HUMAN_PWY-5659 GDP-mannose biosynthesis 0.0360270381420746 -3.323485562928 4 4 0.0101010101010101 396 907 5372,4351,5373,29926 PMM1,MPI,PMM2,GMPPA HUMAN_MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS dolichyl-diphosphooligosaccharide biosynthesis 0.0410633276637018 -3.19263982674679 9 7 0.0176767676767677 396 907 8818,10195,1798,54344,79868,56052,79053 DPM2,ALG3,DPAGT1,DPM3,ALG13,ALG1,ALG8 META_PWY66-341 cholesterol biosynthesis I 0.0496569293211806 -3.00261733486183 11 8 0.0202020202020202 396 907 4047,6307,50814,6309,1717,3930,10682,2222 LSS,MSMO1,NSDHL,SC5D,DHCR7,LBR,EBP,FDFT1 META_PWY66-4 cholesterol biosynthesis III (via desmosterol) 0.0496569293211806 -3.00261733486183 11 8 0.0202020202020202 396 907 4047,6307,50814,6309,1717,3930,10682,2222 LSS,MSMO1,NSDHL,SC5D,DHCR7,LBR,EBP,FDFT1 HUMAN_PWY-7221 guanosine ribonucleotides de novo biosynthesis 0.0496569293211806 -3.00261733486183 11 8 0.0202020202020202 396 907 29922,10201,4830,4831,8833,3614,3615,4832 NME7,NME6,NME1,NME2,GMPS,IMPDH1,IMPDH2,NME3 META_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) 0.0496569293211806 -3.00261733486183 11 8 0.0202020202020202 396 907 4047,6307,50814,6309,1717,3930,10682,2222 LSS,MSMO1,NSDHL,SC5D,DHCR7,LBR,EBP,FDFT1 HUMAN_PWY66-4 cholesterol biosynthesis III (via desmosterol) 0.0561896378633253 -2.87902291873864 13 9 0.0227272727272727 396 907 4047,6307,50814,7108,6309,1717,3930,2222,10682 LSS,MSMO1,NSDHL,TM7SF2,SC5D,DHCR7,LBR,FDFT1,EBP HUMAN_PWY66-341 cholesterol biosynthesis I 0.0561896378633253 -2.87902291873864 13 9 0.0227272727272727 396 907 4047,6307,50814,7108,6309,1717,3930,2222,10682 LSS,MSMO1,NSDHL,TM7SF2,SC5D,DHCR7,LBR,FDFT1,EBP HUMAN_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) 0.0561896378633253 -2.87902291873864 13 9 0.0227272727272727 396 907 4047,6307,50814,7108,6309,1717,3930,2222,10682 LSS,MSMO1,NSDHL,TM7SF2,SC5D,DHCR7,LBR,FDFT1,EBP META_PWY-841 superpathway of purine nucleotides de novo biosynthesis I 0.0561896378633253 -2.87902291873864 13 9 0.0227272727272727 396 907 4830,5471,471,10606,4831,6240,3614,6241,3615 NME1,PPAT,ATIC,PAICS,NME2,RRM1,IMPDH1,RRM2,IMPDH2 META_PWY66-409 superpathway of purine nucleotide salvage 0.0561896378633253 -2.87902291873864 13 9 0.0227272727272727 396 907 3251,4860,4830,6240,4831,6241,3614,3615,132 HPRT1,PNP,NME1,RRM1,NME2,RRM2,IMPDH1,IMPDH2,ADK META_ILEUDEG-PWY L-isoleucine degradation I 0.0599404112136049 -2.81440435669665 6 5 0.0126262626262626 396 907 38,593,594,1629,3028 ACAT1,BCKDHA,BCKDHB,DBT,HSD17B10 HUMAN_PENTOSE-P-PWY pentose phosphate pathway 0.0599404112136049 -2.81440435669665 6 5 0.0126262626262626 396 907 25796,6120,2539,22934,5226 PGLS,RPE,G6PD,RPIA,PGD HUMAN_PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage 0.061132024351292 -2.7947194199771 15 10 0.0252525252525253 396 907 1841,29922,10201,4830,1633,4831,7298,51727,4832,7084 DTYMK,NME7,NME6,NME1,DCK,NME2,TYMS,CMPK1,NME3,TK2 HUMAN_PWY-5514 UDP-N-acetyl-D-galactosamine biosynthesis II 0.0756044936462653 -2.58223955779771 8 6 0.0151515151515152 396 907 91373,132789,80201,64841,10007,2582 UAP1L1,GNPDA2,HKDC1,GNPNAT1,GNPDA1,GALE META_PWY-7228 superpathway of guanosine nucleotides de novo biosynthesis I 0.0756044936462653 -2.58223955779771 8 6 0.0151515151515152 396 907 3614,6241,3615,4830,6240,4831 IMPDH1,RRM2,IMPDH2,NME1,RRM1,NME2 HUMAN_OXIDATIVEPENT-PWY-1 pentose phosphate pathway (oxidative branch) 0.0828713549121072 -2.49046581440439 3 3 0.00757575757575758 396 907 25796,2539,5226 PGLS,G6PD,PGD HUMAN_PWY66-385 dTMP de novo biosynthesis (mitochondrial) 0.0828713549121072 -2.49046581440439 3 3 0.00757575757575758 396 907 7298,6472,200895 TYMS,SHMT2,DHFRL1 META_PWY-2301 myo-inositol biosynthesis 0.0828713549121072 -2.49046581440439 3 3 0.00757575757575758 396 907 3612,54928,3613 IMPA1,IMPAD1,IMPA2 META_PWY-7527 L-methionine salvage cycle III 0.0828713549121072 -2.49046581440439 3 3 0.00757575757575758 396 907 6723,883,4507 SRM,CCBL1,MTAP META_OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) 0.0828713549121072 -2.49046581440439 3 3 0.00757575757575758 396 907 25796,2539,5226 PGLS,G6PD,PGD HUMAN_GLUAMCAT-PWY N-acetylglucosamine degradation I 0.0828713549121072 -2.49046581440439 3 3 0.00757575757575758 396 907 132789,51005,10007 GNPDA2,AMDHD2,GNPDA1 META_PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage 0.0860668512718654 -2.45263094433065 10 7 0.0176767676767677 396 907 7298,1841,51727,4830,1633,7084,4831 TYMS,DTYMK,CMPK1,NME1,DCK,TK2,NME2 HUMAN_PWY-7197 pyrimidine deoxyribonucleotide phosphorylation 0.0860668512718654 -2.45263094433065 10 7 0.0176767676767677 396 907 1841,51727,29922,10201,4830,4832,4831 DTYMK,CMPK1,NME7,NME6,NME1,NME3,NME2 META_PWY66-391 fatty acid beta-oxidation VI (peroxisome) 0.0931273690611421 -2.37378716302326 12 8 0.0202020202020202 396 907 6342,3295,2180,1962,11001,30,51,2181 SCP2,HSD17B4,ACSL1,EHHADH,SLC27A2,ACAA1,ACOX1,ACSL3 HUMAN_PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) 0.0931273690611421 -2.37378716302326 12 8 0.0202020202020202 396 907 38,39,3157,3422,9453,10654,2224,3156 ACAT1,ACAT2,HMGCS1,IDI1,GGPS1,PMVK,FDPS,HMGCR META_PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) 0.0931273690611421 -2.37378716302326 12 8 0.0202020202020202 396 907 38,39,3157,3422,9453,10654,2224,3156 ACAT1,ACAT2,HMGCS1,IDI1,GGPS1,PMVK,FDPS,HMGCR HUMAN_PWY66-407 superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle 0.0961928275473932 -2.34140048180945 38 21 0.053030303030303 396 907 5160,2026,8802,669,6391,3419,4191,5315,1743,6392,50,5211,230,226,1431,8801,4190,5224,3098,3101,5214 PDHA1,ENO2,SUCLG1,BPGM,SDHC,IDH3A,MDH2,PKM,DLST,SDHD,ACO2,PFKL,ALDOC,ALDOA,CS,SUCLG2,MDH1,PGAM2,HK1,HK3,PFKP HUMAN_FAO-PWY fatty acid beta-oxidation 0.0978706034479317 -2.32410904575232 14 9 0.0227272727272727 396 907 2180,11001,2181,1892,3032,10449,3028,6342,1632 ACSL1,SLC27A2,ACSL3,ECHS1,HADHB,ACAA2,HSD17B10,SCP2,ECI1 META_PWY66-398 TCA cycle III (animals) 0.100980202912239 -2.29283079212341 16 10 0.0252525252525253 396 907 50,8802,6391,3419,4191,1431,8801,4190,1743,6392 ACO2,SUCLG1,SDHC,IDH3A,MDH2,CS,SUCLG2,MDH1,DLST,SDHD HUMAN_PWY66-398 TCA cycle 0.100980202912239 -2.29283079212341 16 10 0.0252525252525253 396 907 50,8802,6391,3419,4191,1431,8801,4190,1743,6392 ACO2,SUCLG1,SDHC,IDH3A,MDH2,CS,SUCLG2,MDH1,DLST,SDHD META_PWY-5667 CDP-diacylglycerol biosynthesis I 0.11757661285107 -2.14066513360896 5 4 0.0101010101010101 396 907 56894,55326,56895,10554 AGPAT3,AGPAT5,AGPAT4,AGPAT1 META_PWY-7226 guanosine deoxyribonucleotides de novo biosynthesis I 0.11757661285107 -2.14066513360896 5 4 0.0101010101010101 396 907 6241,4830,6240,4831 RRM2,NME1,RRM1,NME2 HUMAN_UDPNACETYLGALSYN-PWY UDP-N-acetyl-D-glucosamine biosynthesis II 0.11757661285107 -2.14066513360896 5 4 0.0101010101010101 396 907 2673,91373,9945,64841 GFPT1,UAP1L1,GFPT2,GNPNAT1 META_PWY-7227 adenosine deoxyribonucleotides de novo biosynthesis 0.11757661285107 -2.14066513360896 5 4 0.0101010101010101 396 907 6241,4830,6240,4831 RRM2,NME1,RRM1,NME2 META_PWY-7197 pyrimidine deoxyribonucleotide phosphorylation 0.11757661285107 -2.14066513360896 5 4 0.0101010101010101 396 907 1841,51727,4830,4831 DTYMK,CMPK1,NME1,NME2 HUMAN_PWY-5966-1 fatty acid biosynthesis initiation 0.11757661285107 -2.14066513360896 5 4 0.0101010101010101 396 907 27349,4706,31,2194 MCAT,NDUFAB1,ACACA,FASN HUMAN_PWY-7205 CMP phosphorylation 0.144686825612282 -1.93318369570747 9 6 0.0151515151515152 396 907 51727,29922,10201,4830,4832,4831 CMPK1,NME7,NME6,NME1,NME3,NME2 HUMAN_PWY-7527 methionine salvage cycle III 0.144686825612282 -1.93318369570747 9 6 0.0151515151515152 396 907 58478,6723,51074,4507,84245,4144 ENOPH1,SRM,APIP,MTAP,MRI1,MAT2A HUMAN_PWY-7176 UTP and CTP de novo biosynthesis 0.149784214685754 -1.89855958938099 11 7 0.0176767676767677 396 907 51727,29922,10201,4830,4832,56474,4831 CMPK1,NME7,NME6,NME1,NME3,CTPS2,NME2 HUMAN_PWY0-162 superpathway of pyrimidine ribonucleotides de novo biosynthesis 0.15222773897818 -1.88237759669039 13 8 0.0202020202020202 396 907 7372,51727,4830,29922,10201,4832,4831,56474 UMPS,CMPK1,NME1,NME7,NME6,NME3,NME2,CTPS2 HUMAN_PWY66-391 fatty acid beta-oxidation (peroxisome) 0.15222773897818 -1.88237759669039 13 8 0.0202020202020202 396 907 6342,3295,2180,1962,11001,30,51,2181 SCP2,HSD17B4,ACSL1,EHHADH,SLC27A2,ACAA1,ACOX1,ACSL3 META_PWY66-400 glycolysis VI (metazoan) 0.1526033042069 -1.87991350763422 17 10 0.0252525252525253 396 907 2026,669,5211,230,226,5224,3098,5315,3101,5214 ENO2,BPGM,PFKL,ALDOC,ALDOA,PGAM2,HK1,PKM,HK3,PFKP HUMAN_PWY66-400 glycolysis 0.1526033042069 -1.87991350763422 17 10 0.0252525252525253 396 907 2026,669,5211,230,226,5224,3098,5315,3101,5214 ENO2,BPGM,PFKL,ALDOC,ALDOA,PGAM2,HK1,PKM,HK3,PFKP META_PWY-6620 guanine and guanosine salvage 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 3251,4860 HPRT1,PNP META_PWY-7437 protein O-[N-acetyl]-glucosylation 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 10724,8473 MGEA5,OGT HUMAN_PROSYN-PWY proline biosynthesis 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 5832,5831 ALDH18A1,PYCR1 HUMAN_PWY-4821 UDP-D-xylose and UDP-D-glucuronate biosynthesis 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 80146,7358 UXS1,UGDH HUMAN_PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 127253,55253 TYW3,TYW1 HUMAN_PWY-6620 guanine and guanosine salvage 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 3251,4860 HPRT1,PNP HUMAN_PWY-5905 hypusine biosynthesis 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 83475,1725 DOHH,DHPS META_PWY-7511 protein ubiquitylation 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 7317,55284 UBA1,UBE2W META_PLPSAL-PWY pyridoxal 5'-phosphate salvage I 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 55163,8566 PNPO,PDXK HUMAN_PWY-7437 protein O-[N-acetyl]-glucosylation 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 10724,8473 MGEA5,OGT HUMAN_PWY0-1275 lipoate biosynthesis and incorporation 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 51601,11019 LIPT1,LIAS META_PWY-6124 inosine-5'-phosphate biosynthesis II 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 471,10606 ATIC,PAICS HUMAN_FASYN-ELONG-PWY fatty acid elongation -- saturated 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 4706,2194 NDUFAB1,FASN HUMAN_PWY-6124 inosine-5'-phosphate biosynthesis 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 471,10606 ATIC,PAICS HUMAN_PWY-4041 gamma-glutamyl cycle 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 26873,55748 OPLAH,CNDP2 HUMAN_PWY-6012-1 acyl carrier protein metabolism 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 4706,60496 NDUFAB1,AASDHPPT META_PROSYN-PWY L-proline biosynthesis I 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 5832,5831 ALDH18A1,PYCR1 META_PWY-5177 glutaryl-CoA degradation 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 38,39 ACAT1,ACAT2 META_PROUT-PWY L-proline degradation 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 8659,5625 ALDH4A1,PRODH HUMAN_PWY-1801 formaldehyde oxidation 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 128,2098 ADH5,ESD HUMAN_PWY-5137 fatty acid beta-oxidation (unsaturated, odd number) 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 1962,1632 EHHADH,ECI1 META_PWY-7343 UDP-glucose biosynthesis 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 55276,7360 PGM2,UGP2 HUMAN_PWY-2301 myo-inositol de novo biosynthesis 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 3612,3613 IMPA1,IMPA2 META_UDPNACETYLGALSYN-PWY UDP-N-acetyl-D-glucosamine biosynthesis II 0.190351716231974 -1.65888178000318 2 2 0.00505050505050505 396 907 2673,5238 GFPT1,PGM3 HUMAN_PWY66-399 gluconeogenesis 0.21983338961295 -1.51488533948252 16 9 0.0227272727272727 396 907 5091,2026,669,230,4191,226,5224,4190,92579 PC,ENO2,BPGM,ALDOC,MDH2,ALDOA,PGAM2,MDH1,G6PC3 META_PWY66-399 gluconeogenesis III 0.21983338961295 -1.51488533948252 16 9 0.0227272727272727 396 907 5091,2026,669,230,4191,226,5224,4190,92579 PC,ENO2,BPGM,ALDOC,MDH2,ALDOA,PGAM2,MDH1,G6PC3 META_PWY66-423 fructose 2,6-bisphosphate biosynthesis 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 5210,57103,5208 PFKFB4,TIGAR,PFKFB2 HUMAN_PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 594,593,1629 BCKDHB,BCKDHA,DBT META_PWY-7205 CMP phosphorylation 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 51727,4830,4831 CMPK1,NME1,NME2 HUMAN_PWY-5123 trans, trans-farnesyl diphosphate biosynthesis 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 3422,9453,2224 IDI1,GGPS1,FDPS HUMAN_PWY-4361 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 58478,51074,84245 ENOPH1,APIP,MRI1 HUMAN_PWY-2161 folate polyglutamylation 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 6472,2356,4522 SHMT2,FPGS,MTHFD1 META_PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 593,594,1629 BCKDHA,BCKDHB,DBT META_PWY-5123 trans, trans-farnesyl diphosphate biosynthesis 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 3422,9453,2224 IDI1,GGPS1,FDPS HUMAN_PWY-6755 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 58478,51074,84245 ENOPH1,APIP,MRI1 META_POLYAMINSYN3-PWY superpathway of polyamine biosynthesis II 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 6723,4953,113451 SRM,ODC1,AZIN2 META_PWY-7181 pyrimidine deoxyribonucleosides degradation 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 9997,1890,7378 SCO2,TYMP,UPP1 HUMAN_PWY66-423 fructose 2,6-bisphosphate synthesis 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 5210,57103,5208 PFKFB4,TIGAR,PFKFB2 HUMAN_SER-GLYSYN-PWY serine and glycine biosynthesis 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 6472,51699,63826 SHMT2,VPS29,SRR HUMAN_MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 4190,2806,4191 MDH1,GOT2,MDH2 META_PWY-5661 GDP-glucose biosynthesis 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 3098,55276,3101 HK1,PGM2,HK3 HUMAN_PWY66-387 fatty acid alpha-oxidation 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 11001,224,5264 SLC27A2,ALDH3A2,PHYH HUMAN_PWY-5661-1 GDP-glucose biosynthesis II 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 3098,55276,3101 HK1,PGM2,HK3 HUMAN_THIOREDOX-PWY thioredoxin pathway 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 7296,10587,114112 TXNRD1,TXNRD2,TXNRD3 HUMAN_PWY-6517 N-acetylglucosamine degradation II 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 132789,51005,10007 GNPDA2,AMDHD2,GNPDA1 META_PWY66-387 fatty acid alpha-oxidation II 0.223404305221428 -1.4987721211745 4 3 0.00757575757575758 396 907 11001,224,5264 SLC27A2,ALDH3A2,PHYH HUMAN_VALDEG-PWY valine degradation 0.22910379856109 -1.47358010929746 12 7 0.0176767676767677 396 907 27034,4329,594,593,1629,1892,587 ACAD8,ALDH6A1,BCKDHB,BCKDHA,DBT,ECHS1,BCAT2 META_PWY-922 mevalonate pathway I 0.232616787123739 -1.45836286986064 10 6 0.0151515151515152 396 907 38,39,3157,3422,10654,3156 ACAT1,ACAT2,HMGCS1,IDI1,PMVK,HMGCR HUMAN_PWY-922 mevalonate pathway 0.232616787123739 -1.45836286986064 10 6 0.0151515151515152 396 907 38,39,3157,3422,10654,3156 ACAT1,ACAT2,HMGCS1,IDI1,PMVK,HMGCR META_PWY66-428 L-threonine degradation V 0.232849016128937 -1.45736503490544 6 4 0.0101010101010101 396 907 113675,594,593,1629 SDSL,BCKDHB,BCKDHA,DBT META_PWY-7221 guanosine ribonucleotides de novo biosynthesis 0.232849016128937 -1.45736503490544 6 4 0.0101010101010101 396 907 3614,3615,4830,4831 IMPDH1,IMPDH2,NME1,NME2 META_PWY-5972 stearate biosynthesis I (animals and fungi) 0.232849016128937 -1.45736503490544 6 4 0.0101010101010101 396 907 2180,11001,641371,79071 ACSL1,SLC27A2,ACOT1,ELOVL6 META_PWY3DJ-12 ceramide de novo biosynthesis 0.232849016128937 -1.45736503490544 6 4 0.0101010101010101 396 907 2531,171546,9517,8560 KDSR,SPTSSA,SPTLC2,DEGS1 META_PWY-7229 superpathway of adenosine nucleotides de novo biosynthesis I 0.232849016128937 -1.45736503490544 6 4 0.0101010101010101 396 907 6241,4830,6240,4831 RRM2,NME1,RRM1,NME2 HUMAN_PWY-6074 zymosterol biosynthesis 0.232849016128937 -1.45736503490544 6 4 0.0101010101010101 396 907 7108,6307,50814,3930 TM7SF2,MSMO1,NSDHL,LBR META_PWY-7176 UTP and CTP de novo biosynthesis 0.232849016128937 -1.45736503490544 6 4 0.0101010101010101 396 907 51727,4830,56474,4831 CMPK1,NME1,CTPS2,NME2 META_PWY-7277 sphingolipid biosynthesis (mammals) 0.232849016128937 -1.45736503490544 6 4 0.0101010101010101 396 907 2531,171546,9517,8560 KDSR,SPTSSA,SPTLC2,DEGS1 HUMAN_PWY66-428 threonine degradation 0.232849016128937 -1.45736503490544 6 4 0.0101010101010101 396 907 113675,594,593,1629 SDSL,BCKDHB,BCKDHA,DBT HUMAN_PWY-6352 3-phosphoinositide biosynthesis 0.249034170904694 -1.39016515938398 27 14 0.0353535353535354 396 907 8396,5298,5295,5296,30849,22908,8503,138429,5297,9896,8394,10423,200576,55361 PIP4K2B,PI4KB,PIK3R1,PIK3R2,PIK3R4,SACM1L,PIK3R3,PIP5KL1,PI4KA,FIG4,PIP5K1A,CDIPT,PIKFYVE,PI4K2A HUMAN_PWY-7219 adenosine ribonucleotides de novo biosynthesis 0.285022519228548 -1.25518708699798 19 10 0.0252525252525253 396 907 203,27109,122481,509,10476,521,498,506,9551,122622 AK1,ATP5S,AK7,ATP5C1,ATP5H,ATP5I,ATP5A1,ATP5B,ATP5J2,ADSSL1 META_ANAEROFRUCAT-PWY homolactic fermentation 0.306675859792086 -1.18196392047359 15 8 0.0202020202020202 396 907 2026,5211,669,230,226,5224,5315,5214 ENO2,PFKL,BPGM,ALDOC,ALDOA,PGAM2,PKM,PFKP HUMAN_PWY-6567 chondroitin sulfate biosynthesis (late stages) 0.318792534742206 -1.14321474908365 13 7 0.0176767676767677 396 907 9469,22856,50515,51363,55501,55454,9435 CHST3,CHSY1,CHST11,CHST15,CHST12,CSGALNACT2,CHST2 HUMAN_PWY-5972 stearate biosynthesis 0.332015874049531 -1.10257249780647 11 6 0.0151515151515152 396 907 2180,11001,64834,641371,79071,2181 ACSL1,SLC27A2,ELOVL1,ACOT1,ELOVL6,ACSL3 HUMAN_PWY-7224 purine deoxyribonucleosides salvage 0.332015874049531 -1.10257249780647 11 6 0.0151515151515152 396 907 29922,10201,4830,1633,4832,4831 NME7,NME6,NME1,DCK,NME3,NME2 HUMAN_PWY-6353 purine nucleotides degradation 0.34663338683174 -1.0594875796469 9 5 0.0126262626262626 396 907 3614,3615,4860,51251,57665 IMPDH1,IMPDH2,PNP,NT5C3A,RDH14 META_PWY-5920 superpathway of heme biosynthesis from glycine 0.363090199854856 -1.01310399113579 7 4 0.0101010101010101 396 907 210,5498,1371,211 ALAD,PPOX,CPOX,ALAS1 META_LEU-DEG2-PWY L-leucine degradation I 0.363090199854856 -1.01310399113579 7 4 0.0101010101010101 396 907 593,594,1629,56922 BCKDHA,BCKDHB,DBT,MCCC1 META_PWY0-162 superpathway of pyrimidine ribonucleotides de novo biosynthesis 0.363090199854856 -1.01310399113579 7 4 0.0101010101010101 396 907 51727,4830,4831,56474 CMPK1,NME1,NME2,CTPS2 META_PWY-6567 chondroitin sulfate biosynthesis (late stages) 0.363090199854856 -1.01310399113579 7 4 0.0101010101010101 396 907 9469,50515,51363,55501 CHST3,CHST11,CHST15,CHST12 META_PWY-5130 2-oxobutanoate degradation I 0.363090199854856 -1.01310399113579 7 4 0.0101010101010101 396 907 84693,593,594,1629 MCEE,BCKDHA,BCKDHB,DBT HUMAN_PWY-5920 heme biosynthesis 0.363090199854856 -1.01310399113579 7 4 0.0101010101010101 396 907 210,5498,1371,211 ALAD,PPOX,CPOX,ALAS1 HUMAN_PWY-5130 2-oxobutanoate degradation 0.363090199854856 -1.01310399113579 7 4 0.0101010101010101 396 907 84693,594,593,1629 MCEE,BCKDHB,BCKDHA,DBT META_PWY-7199 pyrimidine deoxyribonucleosides salvage 0.382145843781295 -0.961952953235429 5 3 0.00757575757575758 396 907 7298,1633,7084 TYMS,DCK,TK2 HUMAN_PWY-7181 pyrimidine deoxyribonucleosides degradation 0.382145843781295 -0.961952953235429 5 3 0.00757575757575758 396 907 9997,1890,7378 SCO2,TYMP,UPP1 META_CITRULBIO-PWY L-citrulline biosynthesis 0.382145843781295 -0.961952953235429 5 3 0.00757575757575758 396 907 5625,4942,5832 PRODH,OAT,ALDH18A1 HUMAN_COA-PWY-1 coenzyme A biosynthesis 0.382145843781295 -0.961952953235429 5 3 0.00757575757575758 396 907 79717,79646,53354 PPCS,PANK3,PANK1 META_PWY66-367 ketogenesis 0.382145843781295 -0.961952953235429 5 3 0.00757575757575758 396 907 38,39,3157 ACAT1,ACAT2,HMGCS1 HUMAN_PWY4FS-6 phosphatidylethanolamine biosynthesis II 0.382145843781295 -0.961952953235429 5 3 0.00757575757575758 396 907 1375,5833,55500 CPT1B,PCYT2,ETNK1 META_PWY-6074 zymosterol biosynthesis 0.382145843781295 -0.961952953235429 5 3 0.00757575757575758 396 907 6307,3930,50814 MSMO1,LBR,NSDHL META_VALDEG-PWY L-valine degradation I 0.382145843781295 -0.961952953235429 5 3 0.00757575757575758 396 907 593,594,1629 BCKDHA,BCKDHB,DBT HUMAN_PLPSAL-PWY pyridoxal 5'-phosphate salvage 0.382145843781295 -0.961952953235429 5 3 0.00757575757575758 396 907 55163,8566,151230 PNPO,PDXK,KLHL23 META_PWY-4061 glutathione-mediated detoxification I 0.382145843781295 -0.961952953235429 5 3 0.00757575757575758 396 907 56267,2954,883 CCBL2,GSTZ1,CCBL1 META_COA-PWY-1 coenzyme A biosynthesis II (mammalian) 0.382145843781295 -0.961952953235429 5 3 0.00757575757575758 396 907 79717,79646,53354 PPCS,PANK3,PANK1 HUMAN_PWY-7199 pyrimidine deoxyribonucleosides salvage 0.382145843781295 -0.961952953235429 5 3 0.00757575757575758 396 907 7298,1633,7084 TYMS,DCK,TK2 HUMAN_PWY-5695 urate biosynthesis/inosine 5'-phosphate degradation 0.382145843781295 -0.961952953235429 5 3 0.00757575757575758 396 907 3614,3615,4860 IMPDH1,IMPDH2,PNP META_PWY-6352 3-phosphoinositide biosynthesis 0.402740660662336 -0.909462446114254 25 12 0.0303030303030303 396 907 5298,5296,5295,30849,8503,22908,5297,9896,200576,10423,8394,55361 PI4KB,PIK3R2,PIK3R1,PIK3R4,PIK3R3,SACM1L,PI4KA,FIG4,PIKFYVE,CDIPT,PIP5K1A,PI4K2A HUMAN_PWY-5331 taurine biosynthesis 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 51380,84890 CSAD,ADO META_PWY-5664 tetrahydrobiopterin biosynthesis II 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 5805,2643 PTS,GCH1 META_PWY-6609 adenine and adenosine salvage III 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 3251,4860 HPRT1,PNP META_PWY-5331 taurine biosynthesis 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 51380,84890 CSAD,ADO META_ARGININE-SYN4-PWY L-ornithine de novo biosynthesis 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 4942,5832 OAT,ALDH18A1 META_PWY-6000 gamma-linolenate biosynthesis II (animals) 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 2180,11001 ACSL1,SLC27A2 META_MALATE-ASPARTATE-SHUTTLE-PWY L-aspartate degradation II 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 4190,4191 MDH1,MDH2 HUMAN_PWY-6100 L-carnitine biosynthesis 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 223,55217 ALDH9A1,TMLHE HUMAN_PWY-7185 UTP and CTP dephosphorylation I 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 84284,56474 NTPCR,CTPS2 META_PWY0-1296 purine ribonucleosides degradation 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 4860,55276 PNP,PGM2 META_ARGASEDEG-PWY L-arginine degradation I (arginase pathway) 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 8659,4942 ALDH4A1,OAT HUMAN_PWY-6554 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 64768,253430 IPPK,IPMK META_PWY-6100 L-carnitine biosynthesis 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 223,55217 ALDH9A1,TMLHE META_PWY-5663 tetrahydrobiopterin biosynthesis I 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 5805,2643 PTS,GCH1 HUMAN_PWY-5663 tetrahydrobiopterin de novo biosynthesis 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 5805,2643 PTS,GCH1 META_HEME-BIOSYNTHESIS-II heme biosynthesis I (aerobic) 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 5498,1371 PPOX,CPOX META_PWY-7049 icosapentaenoate biosynthesis II (metazoa) 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 60481,2180 ELOVL5,ACSL1 HUMAN_PWY-6609 adenine and adenosine salvage III 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 3251,4860 HPRT1,PNP HUMAN_NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 6120,22934 RPE,RPIA HUMAN_ARGININE-SYN4-PWY ornithine de novo biosynthesis 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 5832,4942 ALDH18A1,OAT HUMAN_PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 4860,55276 PNP,PGM2 HUMAN_HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 5498,1371 PPOX,CPOX HUMAN_PWY-7283 wybutosine biosynthesis 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 127253,55253 TYW3,TYW1 META_PWY-7185 UTP and CTP dephosphorylation I 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 84284,56474 NTPCR,CTPS2 META_PWY66-422 D-galactose degradation V (Leloir pathway) 0.405312438870968 -0.903097055290894 3 2 0.00505050505050505 396 907 55276,2582 PGM2,GALE META_PWY-6756 S-methyl-5'-thioadenosine degradation II 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 4507 MTAP META_PWY-7625 phosphatidylinositol biosynthesis II (eukaryotes) 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 10423 CDIPT HUMAN_P121-PWY adenine and adenosine salvage I 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 353 APRT META_PWY-6273 phosphatidylethanolamine biosynthesis III 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 81490 PTDSS2 META_PWY-7250 [2Fe-2S] iron-sulfur cluster biosynthesis 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 9054 NFS1 META_PWY-5905 hypusine biosynthesis 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 83475 DOHH HUMAN_PWY-7506 phosphatidylserine biosynthesis II 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 81490 PTDSS2 META_PWY-5966 fatty acid biosynthesis initiation II 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 2194 FASN META_PWY-46 putrescine biosynthesis III 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 4953 ODC1 HUMAN_PWY-6898 thiamin salvage III 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 27010 TPK1 META_PWY-5512 UDP-N-acetyl-D-galactosamine biosynthesis I 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 2582 GALE HUMAN_PWY-6132 lanosterol biosynthesis 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 4047 LSS HUMAN_PWY0-522 lipoate salvage 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 51601 LIPT1 HUMAN_PWY-5120 geranylgeranyldiphosphate biosynthesis 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 9453 GGPS1 META_PWY-5326 sulfite oxidation IV 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 6821 SUOX META_PWY66-389 phytol degradation 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 224 ALDH3A2 HUMAN_BGALACT-PWY lactose degradation III 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 2720 GLB1 HUMAN_PWY-40 putrescine biosynthesis II 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 113451 AZIN2 HUMAN_PWY-5512 UDP-N-acetyl-D-galactosamine biosynthesis I 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 2582 GALE META_PWY-7506 phosphatidylserine biosynthesis II 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 81490 PTDSS2 META_PWY-6012-1 acyl carrier protein metabolism II (mammalian) 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 60496 AASDHPPT HUMAN_PROUT-PWY proline degradation 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 8659 ALDH4A1 META_PWY-6502 oxidized GTP and dGTP detoxification 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 4521 NUDT1 META_PWY-5120 geranylgeranyl diphosphate biosynthesis 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 9453 GGPS1 HUMAN_PWY-7592 arachidonate biosynthesis III (metazoa) 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 60481 ELOVL5 HUMAN_PWY-5326 sulfite oxidation 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 6821 SUOX HUMAN_PWY0-1305 glutamate dependent acid resistance 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 2752 GLUL META_GLNSYN-PWY L-glutamine biosynthesis I 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 2752 GLUL HUMAN_SERDEG-PWY L-serine degradation 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 113675 SDSL META_PWY-40 putrescine biosynthesis I 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 113451 AZIN2 META_PWY-6619 adenine and adenosine salvage VI 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 132 ADK META_PWY-7592 arachidonate biosynthesis III (metazoa) 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 60481 ELOVL5 HUMAN_PWY-6756 S-methyl-5'-thioadenosine degradation 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 4507 MTAP HUMAN_PWY66-366 flavin biosynthesis 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 80308 FLAD1 META_PWY-7344 UDP-D-galactose biosynthesis 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 2582 GALE HUMAN_NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and dephosphorylation 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 23530 NNT HUMAN_BSUBPOLYAMSYN-PWY spermidine biosynthesis 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 6723 SRM META_PWY-7501 phosphatidylserine biosynthesis I 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 9791 PTDSS1 META_PWY-6132 lanosterol biosynthesis 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 4047 LSS HUMAN_PWY-46 putrescine biosynthesis I 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 4953 ODC1 HUMAN_MANNCAT-PWY D-mannose degradation 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 4351 MPI HUMAN_PWY-7250 [2Fe-2S] iron-sulfur cluster biosynthesis 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 9054 NFS1 HUMAN_PWY-7501 phosphatidylserine biosynthesis I 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 9791 PTDSS1 META_MGLDLCTANA-PWY methylglyoxal degradation VI 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 197257 LDHD HUMAN_PWY-5963 thio-molybdenum cofactor biosynthesis 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 55034 MOCOS HUMAN_PWY-6502 oxidized GTP and dGTP detoxification 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 4521 NUDT1 META_PWY0-1021 L-alanine biosynthesis III 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 9054 NFS1 HUMAN_SERSYN-PWY serine biosynthesis (phosphorylated route) 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 51699 VPS29 META_NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and dephosphorylation II (mammalian) 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 23530 NNT HUMAN_GLNSYN-PWY glutamine biosynthesis 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 2752 GLUL HUMAN_PWY66-389 phytol degradation 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 224 ALDH3A2 META_PWY-4361 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 883 CCBL1 HUMAN_MGLDLCTANA-PWY methylglyoxal degradation VI 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 197257 LDHD HUMAN_PWY-6619 adenine and adenosine salvage II 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 132 ADK HUMAN_PWY66-11 BMP Signalling Pathway 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 4089 SMAD4 META_BSUBPOLYAMSYN-PWY spermidine biosynthesis I 0.436604189636607 -0.82872823885964 1 1 0.00252525252525253 396 907 6723 SRM HUMAN_PWY-4061 glutathione-mediated detoxification 0.458277659535058 -0.780280035032995 19 9 0.0227272727272727 396 907 2954,373156,883,2948,4259,2952,56267,4258,4257 GSTZ1,GSTK1,CCBL1,GSTM4,MGST3,GSTT1,CCBL2,MGST2,MGST1 HUMAN_PWY-6569 chondroitin sulfate biosynthesis 0.458277659535058 -0.780280035032995 19 9 0.0227272727272727 396 907 50515,51363,55501,64132,9469,22856,9435,55454,11285 CHST11,CHST15,CHST12,XYLT2,CHST3,CHSY1,CHST2,CSGALNACT2,B4GALT7 HUMAN_PWY-2201 folate transformations I 0.491739546890506 -0.709806078897708 8 4 0.0101010101010101 396 907 6472,10797,400410,4522 SHMT2,MTHFD2,ST20,MTHFD1 HUMAN_PWY3DJ-12 ceramide de novo biosynthesis 0.531442671436726 -0.632159948848823 6 3 0.00757575757575758 396 907 2531,171546,9517 KDSR,SPTSSA,SPTLC2 META_PWY66-373 sucrose degradation V (sucrose alpha-glucosidase) 0.531442671436726 -0.632159948848823 6 3 0.00757575757575758 396 907 3795,230,226 KHK,ALDOC,ALDOA HUMAN_PWY3O-450 phosphatidylcholine biosynthesis 0.531442671436726 -0.632159948848823 6 3 0.00757575757575758 396 907 1375,5130,1119 CPT1B,PCYT1A,CHKA HUMAN_PWY-5143 fatty acid activation 0.531442671436726 -0.632159948848823 6 3 0.00757575757575758 396 907 2180,11001,2181 ACSL1,SLC27A2,ACSL3 HUMAN_PWY-5996 oleate biosynthesis 0.531442671436726 -0.632159948848823 6 3 0.00757575757575758 396 907 6319,641371,79966 SCD,ACOT1,SCD5 META_PWY-5695 urate biosynthesis/inosine 5'-phosphate degradation 0.531442671436726 -0.632159948848823 6 3 0.00757575757575758 396 907 3614,3615,4860 IMPDH1,IMPDH2,PNP HUMAN_PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation 0.534472590795867 -0.626474829914474 13 6 0.0151515151515152 396 907 3612,22876,3636,4952,54928,3613 IMPA1,INPP5F,INPPL1,OCRL,IMPAD1,IMPA2 META_PWY-6569 chondroitin sulfate biosynthesis 0.564247196653241 -0.572262831567563 18 8 0.0202020202020202 396 907 50515,51363,55501,64132,9469,22856,55454,11285 CHST11,CHST15,CHST12,XYLT2,CHST3,CHSY1,CSGALNACT2,B4GALT7 META_PWY-5004 superpathway of L-citrulline metabolism 0.567845080284946 -0.565906643440143 11 5 0.0126262626262626 396 907 5625,1373,5832,4942,435 PRODH,CPS1,ALDH18A1,OAT,ASL HUMAN_PWY-6309 L-kynurenine degradation 0.567845080284946 -0.565906643440143 11 5 0.0126262626262626 396 907 56267,883,125061,2806,8942 CCBL2,CCBL1,AFMID,GOT2,KYNU HUMAN_LEU-DEG2-PWY leucine degradation 0.567845080284946 -0.565906643440143 11 5 0.0126262626262626 396 907 594,593,1629,587,56922 BCKDHB,BCKDHA,DBT,BCAT2,MCCC1 META_PWY-5189 tetrapyrrole biosynthesis II (from glycine) 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 210,211 ALAD,ALAS1 META_PWY-7434 terminal O-glycans residues modification 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 11041,6487 B4GAT1,ST3GAL3 HUMAN_HYDROXYPRODEG-PWY 4-hydroxyproline degradation 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 8659,2806 ALDH4A1,GOT2 META_PWY-6405 Rapoport-Luebering glycolytic shunt 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 5224,669 PGAM2,BPGM HUMAN_PWY-6117 spermine and spermidine degradation I 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 112483,6303 SAT2,SAT1 META_PWY-3781 aerobic respiration I (cytochrome c) 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 6391,6392 SDHC,SDHD HUMAN_PWY-6568 dermatan sulfate biosynthesis (late stages) 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 113189,51363 CHST14,CHST15 HUMAN_PWY-7177 UTP and CTP dephosphorylation II 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 124583,56474 CANT1,CTPS2 HUMAN_ASPARAGINE-DEG1-PWY-1 asparagine degradation 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 80150,175 ASRGL1,AGA META_HYDROXYPRODEG-PWY trans-4-hydroxy-L-proline degradation I 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 8659,2806 ALDH4A1,GOT2 META_PWY66-162 ethanol degradation IV 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 847,224 CAT,ALDH3A2 HUMAN_PWY-4984 urea cycle 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 1373,435 CPS1,ASL META_PWY-6568 dermatan sulfate biosynthesis (late stages) 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 113189,51363 CHST14,CHST15 HUMAN_PWY-5872 ubiquinol-10 biosynthesis 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 51805,23590 COQ3,PDSS1 HUMAN_PWY-5189 tetrapyrrole biosynthesis 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 210,211 ALAD,ALAS1 HUMAN_PWY-6307 tryptophan degradation via tryptamine 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 224,10327 ALDH3A2,AKR1A1 META_PWY-5872 ubiquinol-10 biosynthesis (eukaryotic) 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 51805,23590 COQ3,PDSS1 META_PWY-5994 palmitate biosynthesis I (animals and fungi) 0.587220572525337 -0.532354767340947 4 2 0.00505050505050505 396 907 641371,2194 ACOT1,FASN META_PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) 0.607824474939608 -0.497869131229221 9 4 0.0101010101010101 396 907 56267,883,2806,8942 CCBL2,CCBL1,GOT2,KYNU HUMAN_PWY-0 putrescine degradation III 0.607824474939608 -0.497869131229221 9 4 0.0101010101010101 396 907 221,112483,224,6303 ALDH3B1,SAT2,ALDH3A2,SAT1 HUMAN_PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism 0.607824474939608 -0.497869131229221 9 4 0.0101010101010101 396 907 427,8877,22949,56848 ASAH1,SPHK1,PTGR1,SPHK2 HUMAN_PWY-5328 superpathway of methionine degradation 0.625666171543833 -0.468938322416476 14 6 0.0151515151515152 396 907 84693,6821,594,593,1629,4144 MCEE,SUOX,BCKDHB,BCKDHA,DBT,MAT2A HUMAN_PWY66-374 C20 prostanoid biosynthesis 0.657707025125601 -0.418995697379284 7 3 0.00757575757575758 396 907 5743,10728,6916 PTGS2,PTGES3,TBXAS1 META_PWY-7224 purine deoxyribonucleosides salvage 0.657707025125601 -0.418995697379284 7 3 0.00757575757575758 396 907 4830,1633,4831 NME1,DCK,NME2 HUMAN_PWY-5994 palmitate biosynthesis 0.657707025125601 -0.418995697379284 7 3 0.00757575757575758 396 907 4706,641371,2194 NDUFAB1,ACOT1,FASN HUMAN_SALVADEHYPOX-PWY adenosine nucleotides degradation 0.657707025125601 -0.418995697379284 7 3 0.00757575757575758 396 907 4860,51251,57665 PNP,NT5C3A,RDH14 META_PWY66-374 C20 prostanoid biosynthesis 0.657707025125601 -0.418995697379284 7 3 0.00757575757575758 396 907 5743,10728,6916 PTGS2,PTGES3,TBXAS1 HUMAN_PWY-6369 inositol pyrophosphates biosynthesis 0.657707025125601 -0.418995697379284 7 3 0.00757575757575758 396 907 64768,9807,253430 IPPK,IP6K1,IPMK HUMAN_PWY66-373 sucrose degradation 0.657707025125601 -0.418995697379284 7 3 0.00757575757575758 396 907 3795,230,226 KHK,ALDOC,ALDOA HUMAN_PWY-5067 glycogen biosynthesis 0.657707025125601 -0.418995697379284 7 3 0.00757575757575758 396 907 2632,7360,55276 GBE1,UGP2,PGM2 META_PWY-6369 inositol pyrophosphates biosynthesis 0.657707025125601 -0.418995697379284 7 3 0.00757575757575758 396 907 64768,9807,253430 IPPK,IP6K1,IPMK META_DETOX1-PWY-1 reactive oxygen species degradation 0.657707025125601 -0.418995697379284 7 3 0.00757575757575758 396 907 847,2876,6648 CAT,GPX1,SOD2 HUMAN_PWY-6365 D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 253430 IPMK HUMAN_PWY-6405 Rapoport-Luebering glycolytic shunt 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 669 BPGM META_CHOLINE-BETAINE-ANA-PWY choline degradation I 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 55349 CHDH HUMAN_PWY-6129 dolichol and dolichyl phosphate biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 79947 DHDDS META_PWY-6117 spermine and spermidine degradation I 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 6303 SAT1 HUMAN_PWY-7179-1 purine deoxyribonucleosides degradation 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 4860 PNP META_PWY-4041 gamma-glutamyl cycle 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 2729 GCLC META_PWY66-394 aspirin triggered resolvin E biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 5743 PTGS2 META_PWY-5340 sulfate activation for sulfonation 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 9061 PAPSS1 HUMAN_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 5471 PPAT META_PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 4522 MTHFD1 HUMAN_PWY-6118 glycerol-3-phosphate shuttle 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 2819 GPD1 META_PWY0-1295 pyrimidine ribonucleosides degradation 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 7378 UPP1 META_PWY-6688 thyronamine and iodothyronamine metabolism 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 1734 DIO2 HUMAN_BETA-ALA-DEGRADATION-I-PWY beta-alanine degradation 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 4329 ALDH6A1 META_PWY66-366 flavin biosynthesis IV (mammalian) 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 80308 FLAD1 META_PWY-5874 heme degradation 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 644 BLVRA META_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 5471 PPAT META_PWY3O-4106 NAD salvage pathway III 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 64802 NMNAT1 META_PWY-6365 D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 253430 IPMK META_PWY-6118 glycerol-3-phosphate shuttle 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 2819 GPD1 HUMAN_PWY-5686 UMP biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 7372 UMPS HUMAN_PWY-5525 D-glucuronate degradation 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 51181 DCXR HUMAN_PWY-5481 lactate fermentation (reoxidation of cytosolic NADH) 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 3945 LDHB HUMAN_PWY66-14 MAP kinase cascade 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 5604 MAP2K1 HUMAN_PWY-5340 sulfate activation for sulfonation 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 9061 PAPSS1 HUMAN_GLUTAMINDEG-PWY glutamine degradation/glutamate biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 2744 GLS META_PWY-5030 L-histidine degradation III 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 4522 MTHFD1 HUMAN_PWY-6688 thyronamine and iodothyronamine metabolism 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 1734 DIO2 HUMAN_PWY-5386 methylglyoxal degradation I 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 197257 LDHD META_PWY-5806 all-trans-decaprenyl diphosphate biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 23590 PDSS1 META_PWY66-395 aspirin triggered resolvin D biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 5743 PTGS2 HUMAN_PWY66-393 aspirin-triggered lipoxin biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 5743 PTGS2 META_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 6472 SHMT2 HUMAN_PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 4522 MTHFD1 HUMAN_PWY-5670 epoxysqualene biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 2222 FDFT1 HUMAN_PWY66-394 aspirin triggered resolvin E biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 5743 PTGS2 HUMAN_PWY66-395 aspirin triggered resolvin D biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 5743 PTGS2 META_PWY66-393 aspirin-triggered lipoxin biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 5743 PTGS2 META_SERDEG-PWY L-serine degradation 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 113675 SDSL META_PWY-5670 epoxysqualene biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 2222 FDFT1 HUMAN_PWY-6260 thyroid hormone metabolism I (via deiodination) 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 1734 DIO2 META_PWY-7179-1 purine deoxyribonucleosides degradation 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 4860 PNP META_PWY-6307 L-tryptophan degradation X (mammalian, via tryptamine) 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 224 ALDH3A2 META_PWY66-388 fatty acid alpha-oxidation III 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 224 ALDH3A2 META_PWY-5453 methylglyoxal degradation III 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 231 AKR1B1 META_PWY-5505 L-glutamate and L-glutamine biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 2752 GLUL HUMAN_GLYSYN-PWY glycine/serine biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 6472 SHMT2 HUMAN_PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 197258 FUK HUMAN_ASPARAGINE-BIOSYNTHESIS asparagine biosynthesis 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 440 ASNS HUMAN_CHOLINE-BETAINE-ANA-PWY choline degradation 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 55349 CHDH META_PWY-6260 thyroid hormone metabolism I (via deiodination) 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 1734 DIO2 HUMAN_PWY-6608 guanosine nucleotides degradation 0.682856663031482 -0.381470305225758 2 1 0.00252525252525253 396 907 4860 PNP HUMAN_PWY-6571 dermatan sulfate biosynthesis 0.705569766870281 -0.348749622613596 15 6 0.0151515151515152 396 907 113189,22856,51363,64132,11285,55454 CHST14,CHSY1,CHST15,XYLT2,B4GALT7,CSGALNACT2 META_PWY-6571 dermatan sulfate biosynthesis 0.705569766870281 -0.348749622613596 15 6 0.0151515151515152 396 907 113189,22856,51363,64132,11285,55454 CHST14,CHSY1,CHST15,XYLT2,B4GALT7,CSGALNACT2 HUMAN_DETOX1-PWY-1 reactive oxygen species degradation 0.70594080054068 -0.348223896930047 10 4 0.0101010101010101 396 907 847,2876,493869,6648 CAT,GPX1,GPX8,SOD2 HUMAN_PWY-7049 icosapentaenoate biosynthesis II (metazoa) 0.70594080054068 -0.348223896930047 10 4 0.0101010101010101 396 907 60481,2180,2181,6296 ELOVL5,ACSL1,ACSL3,ACSM3 HUMAN_PWY-6358 superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism 0.710024018261044 -0.342456480982266 20 8 0.0202020202020202 396 907 3612,22876,3636,3706,4952,54928,3613,253430 IMPA1,INPP5F,INPPL1,ITPKA,OCRL,IMPAD1,IMPA2,IPMK META_PWY-7433 mucin core 1 and core 2 O-glycosylation 0.723937058358661 -0.323050826344271 5 2 0.00505050505050505 396 907 56913,6482 C1GALT1,ST3GAL1 META_PWY-6566 chondroitin biosynthesis 0.723937058358661 -0.323050826344271 5 2 0.00505050505050505 396 907 22856,55454 CHSY1,CSGALNACT2 HUMAN_PWY-6566 chondroitin and dermatan biosynthesis 0.723937058358661 -0.323050826344271 5 2 0.00505050505050505 396 907 22856,55454 CHSY1,CSGALNACT2 HUMAN_PWY-7180 2'-deoxy-alpha-D-ribose 1-phosphate degradation 0.723937058358661 -0.323050826344271 5 2 0.00505050505050505 396 907 221,55276 ALDH3B1,PGM2 META_PWY-6111 mitochondrial L-carnitine shuttle 0.723937058358661 -0.323050826344271 5 2 0.00505050505050505 396 907 1375,1384 CPT1B,CRAT HUMAN_PWY66-162 ethanol degradation IV 0.723937058358661 -0.323050826344271 5 2 0.00505050505050505 396 907 847,224 CAT,ALDH3A2 HUMAN_PWY66-241 bupropion degradation 0.723937058358661 -0.323050826344271 5 2 0.00505050505050505 396 907 113612,29785 CYP2U1,CYP2S1 HUMAN_PWY66-422 D-galactose degradation V (Leloir pathway) 0.723937058358661 -0.323050826344271 5 2 0.00505050505050505 396 907 55276,2582 PGM2,GALE META_PWY-4984 urea cycle 0.723937058358661 -0.323050826344271 5 2 0.00505050505050505 396 907 1373,435 CPS1,ASL HUMAN_PWY-6111 mitochondrial L-carnitine shuttle 0.723937058358661 -0.323050826344271 5 2 0.00505050505050505 396 907 1375,1384 CPT1B,CRAT META_PWY-7209 superpathway of pyrimidine ribonucleosides degradation 0.723937058358661 -0.323050826344271 5 2 0.00505050505050505 396 907 1806,7378 DPYD,UPP1 META_PWY-4081 glutathione redox reactions I 0.723937058358661 -0.323050826344271 5 2 0.00505050505050505 396 907 2876,2879 GPX1,GPX4 HUMAN_PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis 0.742198290962684 -0.298138833022419 23 9 0.0227272727272727 396 907 5335,8396,5298,79837,138429,5297,10423,8394,55361 PLCG1,PIP4K2B,PI4KB,PIP4K2C,PIP5KL1,PI4KA,CDIPT,PIP5K1A,PI4K2A META_PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis 0.742981698693988 -0.297083866204366 13 5 0.0126262626262626 396 907 5297,5298,8394,10423,55361 PI4KA,PI4KB,PIP5K1A,CDIPT,PI4K2A META_TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation III (eukaryotic) 0.757287512068058 -0.278012293070873 8 3 0.00757575757575758 396 907 38,39,8942 ACAT1,ACAT2,KYNU HUMAN_PWY-5451 acetone degradation I (to methylglyoxal) 0.757287512068058 -0.278012293070873 8 3 0.00757575757575758 396 907 231,113612,29785 AKR1B1,CYP2U1,CYP2S1 HUMAN_PWY-7434 terminal O-glycans residues modification 0.757287512068058 -0.278012293070873 8 3 0.00757575757575758 396 907 11041,6487,8704 B4GAT1,ST3GAL3,B4GALT2 META_PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation 0.784852640687416 -0.242259297690654 11 4 0.0101010101010101 396 907 3612,4952,54928,3613 IMPA1,OCRL,IMPAD1,IMPA2 HUMAN_LIPAS-PWY triacylglycerol degradation 0.784852640687416 -0.242259297690654 11 4 0.0101010101010101 396 907 9388,8228,26090,57406 LIPG,PNPLA4,ABHD12,ABHD6 META_PWY-6358 superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism 0.798161102068143 -0.22544481961691 19 7 0.0176767676767677 396 907 3612,3636,3706,4952,54928,3613,253430 IMPA1,INPPL1,ITPKA,OCRL,IMPAD1,IMPA2,IPMK META_PWY-5328 superpathway of L-methionine salvage and degradation 0.808156991556161 -0.212998942853761 14 5 0.0126262626262626 396 907 84693,6821,593,594,1629 MCEE,SUOX,BCKDHA,BCKDHB,DBT HUMAN_PWY-6557 glycoaminoglycan-protein linkage region biosynthesis 0.820184251822666 -0.198226266619791 6 2 0.00505050505050505 396 907 64132,11285 XYLT2,B4GALT7 HUMAN_PWY-4081 glutathione redox reactions I 0.820184251822666 -0.198226266619791 6 2 0.00505050505050505 396 907 2876,2879 GPX1,GPX4 HUMAN_PWY-7209 pyrimidine ribonucleosides degradation 0.820184251822666 -0.198226266619791 6 2 0.00505050505050505 396 907 1806,7378 DPYD,UPP1 META_PWY-5327 superpathway of L-lysine degradation 0.820184251822666 -0.198226266619791 6 2 0.00505050505050505 396 907 38,39 ACAT1,ACAT2 META_PWY-6557 glycoaminoglycan-protein linkage region biosynthesis 0.820184251822666 -0.198226266619791 6 2 0.00505050505050505 396 907 64132,11285 XYLT2,B4GALT7 HUMAN_PROPIONMET-PWY propionyl-CoA degradation 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 84693 MCEE META_PWY-5996 oleate biosynthesis II (animals and fungi) 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 641371 ACOT1 META_PROPIONMET-PWY propanoyl CoA degradation I 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 84693 MCEE META_PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 1743 DLST HUMAN_PWY-6366 D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 253430 IPMK HUMAN_PWY0-1295 pyrimidine ribonucleosides degradation 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 7378 UPP1 HUMAN_PWY66-388 fatty acid alpha-oxidation III 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 224 ALDH3A2 META_ASPARAGINE-DEG1-PWY-1 L-asparagine degradation III (mammalian) 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 175 AGA META_PWY-7606 docosahexaenoate biosynthesis III (mammals) 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 60481 ELOVL5 HUMAN_PWY-4202 arsenate detoxification I (glutaredoxin) 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 4860 PNP META_GLYCLEAV-PWY glycine cleavage 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 2731 GLDC META_PWY6666-2 dopamine degradation 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 224 ALDH3A2 HUMAN_PWY-6430 thymine degradation 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 1806 DPYD HUMAN_PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 1743 DLST META_PWY-6366 D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 253430 IPMK HUMAN_PWY-3982 uracil degradation 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 1806 DPYD HUMAN_METHIONINE-DEG1-PWY methionine degradation 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 4144 MAT2A META_PWY-0 putrescine degradation III 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 224 ALDH3A2 META_PWY-5451 acetone degradation I (to methylglyoxal) 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 231 AKR1B1 HUMAN_NAD-BIOSYNTHESIS-III NAD salvage 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 64802 NMNAT1 META_PWY-7177 UTP and CTP dephosphorylation II 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 56474 CTPS2 META_PWY66-425 L-lysine degradation II (L-pipecolate pathway) 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 5831 PYCR1 META_PWY-4202 arsenate detoxification I (glutaredoxin) 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 4860 PNP META_PWY-3982 uracil degradation I (reductive) 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 1806 DPYD HUMAN_GLYCLEAV-PWY glycine cleavage 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 2731 GLDC META_PWY-7466 acetone degradation III (to propane-1,2-diol) 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 231 AKR1B1 HUMAN_GLUDEG-I-PWY GABA shunt 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 2752 GLUL HUMAN_SAM-PWY S-adenosyl-L-methionine biosynthesis 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 4144 MAT2A HUMAN_PWY-5453 methylglyoxal degradation III 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 231 AKR1B1 META_GLYCINE-SYN2-PWY glycine biosynthesis II 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 2731 GLDC HUMAN_PWY0-1264 biotin-carboxyl carrier protein assembly 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 31 ACACA HUMAN_PWY-7606 docosahexaenoate biosynthesis III (mammals) 0.821628775122094 -0.196466597706875 3 1 0.00252525252525253 396 907 60481 ELOVL5 META_PWY-6558 heparan sulfate biosynthesis (late stages) 0.828189575447198 -0.188513194949165 17 6 0.0151515151515152 396 907 9953,2131,8509,2132,266722,26035 HS3ST3B1,EXT1,NDST2,EXT2,HS6ST3,GLCE META_PWY-6353 purine nucleotides degradation II (aerobic) 0.832019030634986 -0.183899965063162 9 3 0.00757575757575758 396 907 3614,3615,4860 IMPDH1,IMPDH2,PNP HUMAN_PWY-6000 gamma-linolenate biosynthesis 0.845886017052468 -0.167370660069501 12 4 0.0101010101010101 396 907 2180,11001,2181,6296 ACSL1,SLC27A2,ACSL3,ACSM3 HUMAN_PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) 0.859450603902278 -0.15146192654689 15 5 0.0126262626262626 396 907 64768,3636,3706,4952,253430 IPPK,INPPL1,ITPKA,OCRL,IPMK META_PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) 0.859450603902278 -0.15146192654689 15 5 0.0126262626262626 396 907 64768,3636,3706,4952,253430 IPPK,INPPL1,ITPKA,OCRL,IPMK META_PWY-6564 heparan sulfate biosynthesis 0.860922851449678 -0.149750381995656 23 8 0.0202020202020202 396 907 8509,64132,2131,9953,2132,11285,26035,266722 NDST2,XYLT2,EXT1,HS3ST3B1,EXT2,B4GALT7,GLCE,HS6ST3 HUMAN_PWY-5651 tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 0.885175142504298 -0.121969752419254 7 2 0.00505050505050505 396 907 125061,8942 AFMID,KYNU HUMAN_PWY66-221 nicotine degradation III 0.885175142504298 -0.121969752419254 7 2 0.00505050505050505 396 907 113612,29785 CYP2U1,CYP2S1 HUMAN_PWY66-414 superpathway of choline degradation to L-serine 0.885175142504298 -0.121969752419254 7 2 0.00505050505050505 396 907 6472,55349 SHMT2,CHDH HUMAN_PWY-6398 melatonin degradation I 0.886052557820977 -0.120979009796735 10 3 0.00757575757575758 396 907 113612,29785,1545 CYP2U1,CYP2S1,CYP1B1 META_PWY-6823 molybdenum cofactor biosynthesis 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 9054 NFS1 META_PWY66-368 ketolysis 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 38 ACAT1 HUMAN_PWY6666-2 dopamine degradation 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 224 ALDH3A2 HUMAN_2PHENDEG-PWY phenylethylamine degradation I 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 224 ALDH3A2 HUMAN_PWY-6158 creatine-phosphate biosynthesis 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 1152 CKB HUMAN_PWY66-368 ketolysis 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 38 ACAT1 META_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 5160 PDHA1 META_PWY66-21 ethanol degradation II 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 224 ALDH3A2 HUMAN_PWY-6292 cysteine biosynthesis 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 4144 MAT2A META_PWY-6158 creatine-phosphate biosynthesis 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 1152 CKB META_PWY-5067 glycogen biosynthesis II (from UDP-D-Glucose) 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 2632 GBE1 HUMAN_PWY66-367 ketogenesis 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 38 ACAT1 META_PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 64802 NMNAT1 META_PWY-6318 L-phenylalanine degradation IV (mammalian, via side chain) 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 224 ALDH3A2 META_PWY-6608 guanosine nucleotides degradation III 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 4860 PNP HUMAN_PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 64802 NMNAT1 META_PWY66-161 oxidative ethanol degradation III 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 224 ALDH3A2 HUMAN_PWY-5874 heme degradation 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 644 BLVRA META_PWY-6061 bile acid biosynthesis, neutral pathway 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 11001 SLC27A2 HUMAN_PWY-6823 molybdenum cofactor biosynthesis 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 9054 NFS1 HUMAN_PWY66-425 lysine degradation II (pipecolate pathway) 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 5831 PYCR1 HUMAN_PWY-4261 glycerol degradation 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 2710 GK HUMAN_PWY-6261 thyroid hormone metabolism II (via conjugation and/or degradation) 0.899764842660791 -0.105621835731398 4 1 0.00252525252525253 396 907 1734 DIO2 HUMAN_PWY-7433 mucin core 1 and core 2 O-glycosylation 0.920590278951034 -0.0827402071257082 25 8 0.0202020202020202 396 907 56913,6484,8693,63917,51809,55568,374378,6482 C1GALT1,ST3GAL4,GALNT4,GALNT11,GALNT7,GALNT10,GALNT18,ST3GAL1 HUMAN_PWY-6402 superpathway of melatonin degradation 0.924002526746686 -0.0790404727698567 11 3 0.00757575757575758 396 907 113612,29785,1545 CYP2U1,CYP2S1,CYP1B1 HUMAN_NADSYN-PWY NAD de novo biosynthesis 0.924002526746686 -0.0790404727698567 11 3 0.00757575757575758 396 907 64802,125061,8942 NMNAT1,AFMID,KYNU HUMAN_TRYPTOPHAN-DEGRADATION-1 tryptophan degradation 0.927804352651278 -0.0749343953074471 8 2 0.00505050505050505 396 907 125061,8942 AFMID,KYNU META_PWY-7426 mannosyl-glycoprotein N-acetylglucosaminyltransferases 0.927804352651278 -0.0749343953074471 8 2 0.00505050505050505 396 907 4122,4245 MAN2A2,MGAT1 HUMAN_PWY-6368 3-phosphoinositide degradation 0.93219205200266 -0.0702164211443578 20 6 0.0151515151515152 396 907 22908,22876,3636,4952,90809,23203 SACM1L,INPP5F,INPPL1,OCRL,TMEM55B,PMPCA HUMAN_PWY-6558 heparan sulfate biosynthesis (late stages) 0.93219205200266 -0.0702164211443578 20 6 0.0151515151515152 396 907 9953,2131,8509,2132,266722,26035 HS3ST3B1,EXT1,NDST2,EXT2,HS6ST3,GLCE HUMAN_PWY-6564 heparan sulfate biosynthesis 0.941095887828662 -0.0607102446640128 26 8 0.0202020202020202 396 907 8509,64132,2131,9953,2132,11285,26035,266722 NDST2,XYLT2,EXT1,HS3ST3B1,EXT2,B4GALT7,GLCE,HS6ST3 HUMAN_PWY66-380 estradiol biosynthesis I 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 51170 HSD17B11 HUMAN_PWY-4983 citrulline-nitric oxide cycle 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 435 ASL HUMAN_PWY-3661-1 glycine betaine degradation 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 6472 SHMT2 META_PWY-3661-1 glycine betaine degradation II (mammalian) 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 6472 SHMT2 META_TYRFUMCAT-PWY L-tyrosine degradation I 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 2954 GSTZ1 META_SALVADEHYPOX-PWY adenosine nucleotides degradation II 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 4860 PNP META_PWY-6313 serotonin degradation 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 224 ALDH3A2 HUMAN_TYRFUMCAT-PWY tyrosine degradation 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 2954 GSTZ1 HUMAN_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 5160 PDHA1 META_PWY-6398 melatonin degradation I 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 1545 CYP1B1 META_PWY-4983 L-citrulline-nitric oxide cycle 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 435 ASL META_PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 8942 KYNU META_PWY-6402 superpathway of melatonin degradation 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 1545 CYP1B1 HUMAN_PWY66-21 ethanol degradation II 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 224 ALDH3A2 META_PWY-6261 thyroid hormone metabolism II (via conjugation and/or degradation) 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 1734 DIO2 HUMAN_PWY-5030 histidine degradation 0.943721788741834 -0.0579238715895838 5 1 0.00252525252525253 396 907 4522 MTHFD1 HUMAN_PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis 0.948845663448728 -0.0525091243159029 15 4 0.0101010101010101 396 907 3636,3706,4952,253430 INPPL1,ITPKA,OCRL,IPMK META_PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis 0.948845663448728 -0.0525091243159029 15 4 0.0101010101010101 396 907 3636,3706,4952,253430 INPPL1,ITPKA,OCRL,IPMK HUMAN_PWY-6371 superpathway of inositol phosphate compounds 0.949376983692867 -0.0519493161618754 66 23 0.0580808080808081 396 907 3636,9807,90809,5295,79837,30849,5297,8394,10423,55361,8396,5335,64768,5298,4952,5296,253430,22908,8503,138429,9896,3706,200576 INPPL1,IP6K1,TMEM55B,PIK3R1,PIP4K2C,PIK3R4,PI4KA,PIP5K1A,CDIPT,PI4K2A,PIP4K2B,PLCG1,IPPK,PI4KB,OCRL,PIK3R2,IPMK,SACM1L,PIK3R3,PIP5KL1,FIG4,ITPKA,PIKFYVE HUMAN_PWY-6061 bile acid biosynthesis, neutral pathway 0.950041363314249 -0.0512497550046145 12 3 0.00757575757575758 396 907 6342,11001,10449 SCP2,SLC27A2,ACAA2 META_NADSYN-PWY NAD biosynthesis II (from tryptophan) 0.955171587515996 -0.0458642818490107 9 2 0.00505050505050505 396 907 64802,8942 NMNAT1,KYNU META_PWY-6368 3-phosphoinositide degradation 0.965204744482869 -0.0354150296995484 19 5 0.0126262626262626 396 907 22908,22876,3636,4952,90809 SACM1L,INPP5F,INPPL1,OCRL,TMEM55B META_PWY-6342 noradrenaline and adrenaline degradation 0.968429296130006 -0.0320798022795713 6 1 0.00252525252525253 396 907 224 ALDH3A2 HUMAN_PWY66-161 oxidative ethanol degradation III 0.968429296130006 -0.0320798022795713 6 1 0.00252525252525253 396 907 224 ALDH3A2 HUMAN_PWY66-201 nicotine degradation IV 0.972451344942471 -0.0279352356486081 10 2 0.00505050505050505 396 907 113612,29785 CYP2U1,CYP2S1 HUMAN_PWY3DJ-11281 sphingomyelin metabolism/ceramide salvage 0.982304988404622 -0.0178534400238462 7 1 0.00252525252525253 396 907 142891 SAMD8 HUMAN_PWY-6313 serotonin degradation 0.982304988404622 -0.0178534400238462 7 1 0.00252525252525253 396 907 224 ALDH3A2 META_PWY-6857 retinol biosynthesis 0.989853026123825 -0.0101988053353319 12 2 0.00505050505050505 396 907 9249,51109 DHRS3,RDH11 META_PWY-6861 the visual cycle I (vertebrates) 0.993904959709854 -0.00611369087085985 13 2 0.00505050505050505 396 907 9249,51109 DHRS3,RDH11 META_PWY-6367 D-myo-inositol-5-phosphate metabolism 0.994455694267274 -0.0055597324424415 9 1 0.00252525252525253 396 907 90809 TMEM55B HUMAN_PWY-6367 D-myo-inositol-5-phosphate metabolism 0.994777545256421 -0.00523613942623688 17 3 0.00757575757575758 396 907 5335,90809,79837 PLCG1,TMEM55B,PIP4K2C HUMAN_PWY66-401 superpathway of tryptophan utilization 0.996221029170653 -0.00378612917943246 34 8 0.0202020202020202 396 907 113612,64802,125061,224,8942,29785,10327,1545 CYP2U1,NMNAT1,AFMID,ALDH3A2,KYNU,CYP2S1,AKR1A1,CYP1B1 HUMAN_PWY-6342 noradrenaline and adrenaline degradation 0.9969006219728 -0.00310419104676174 10 1 0.00252525252525253 396 907 224 ALDH3A2 HUMAN_PWY-6861 the visual cycle I (vertebrates) 0.997837365091954 -0.00216497677993755 15 2 0.00505050505050505 396 907 9249,51109 DHRS3,RDH11 HUMAN_PWY-6857 retinol biosynthesis 0.999246898958451 -0.000753384764595931 17 2 0.00505050505050505 396 907 9249,51109 DHRS3,RDH11 HUMAN_LIPASYN-PWY phospholipases 0.999471577630081 -0.000528562034223311 29 5 0.0126262626262626 396 907 5335,81579,5337,50640,11145 PLCG1,PLA2G12A,PLD1,PNPLA8,PLA2G16 HUMAN_PWY-7305 superpathway of steroid hormone biosynthesis 0.999699979364928 -0.000300065650266462 14 1 0.00252525252525253 396 907 51170 HSD17B11 HUMAN_PWY0-1313 acetate conversion to acetyl-CoA 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 META_PWY-6076 vitamin D3 biosynthesis 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_PWY0-662 PRPP biosynthesis 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_PWY-6076 vitamin D3 biosynthesis 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_GLYSYN-ALA-PWY glycine biosynthesis 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 META_PWY66-397 resolvin D biosynthesis 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_PWY66-301 catecholamine biosynthesis 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 META_PWY-6138 CMP-N-acetylneuraminate biosynthesis I (eukaryotes) 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_PWY6666-1 anandamide degradation 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_PWY-6370 ascorbate recycling (cytosolic) 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_PWY66-397 resolvin D biosynthesis 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_PWY-6241 thyroid hormone biosynthesis 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_ASPARTATESYN-PWY aspartate biosynthesis 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 META_LYSINE-DEG1-PWY L-lysine degradation XI (mammalian) 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_PWY-6138 CMP-N-acetylneuraminate biosynthesis I (eukaryotes) 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 META_PWY66-380 estradiol biosynthesis I (via estrone) 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_PWY-6482 diphthamide biosynthesis 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_CYSTEINE-DEG-PWY L-cysteine degradation I 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_PWY-5269 cardiolipin biosynthesis 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_PWY-6181 histamine degradation 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 META_PWY0-662 PRPP biosynthesis I 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_LYSINE-DEG1-PWY lysine degradation I (saccharopine pathway) 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 META_GLUDEG-I-PWY GABA shunt 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 META_PWY-6145 superpathway of sialic acids and CMP-sialic acids biosynthesis 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 HUMAN_PWY-7306 estradiol biosynthesis II 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 META_PWY-6370 ascorbate recycling (cytosolic) 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 META_PWY-6181 histamine degradation 0.999999999991036 -8.96419050100405e-12 2 0 0 396 907 META_PWY66-382 mineralocorticoid biosynthesis 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 META_ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 HUMAN_PWY-7193 pyrimidine ribonucleosides salvage I 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 HUMAN_PWY66-381 glucocorticoid biosynthesis 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 META_PWY66-392 lipoxin biosynthesis 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 HUMAN_PWY-6875 retinoate biosynthesis II 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 HUMAN_PWY66-382 mineralocorticoid biosynthesis 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 HUMAN_ADENOSYLHOMOCYSCAT-PWY methionine salvage 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 META_PWY66-381 glucocorticoid biosynthesis 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 META_PWY66-301 catecholamine biosynthesis 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 META_PWY-6875 retinoate biosynthesis II 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 HUMAN_PWY0-1182 trehalose degradation 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 META_PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 META_PWY-7193 pyrimidine ribonucleosides salvage I 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 HUMAN_PHENYLALANINE-DEG1-PWY phenylalanine degradation/tyrosine biosynthesis 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 META_PWY66-221 nicotine degradation V 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 HUMAN_PWY66-392 lipoxin biosynthesis 0.999999999997826 -2.1737195377014e-12 3 0 0 396 907 META_PWY-6292 superpathway of L-cysteine biosynthesis (mammalian) 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-6133 (S)-reticuline biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY66-421 homocarnosine biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-5329 L-cysteine degradation III 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_ASPARTATESYN-PWY L-aspartate biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-5686 UMP biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_ALANINE-SYN2-PWY L-alanine biosynthesis II 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-5148 acyl-CoA hydrolysis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-6399 melatonin degradation II 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_GLYCGREAT-PWY creatine biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-6377 alpha-tocopherol degradation 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_GLYCGREAT-PWY creatine biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_GLUT-REDOX-PWY glutathione redox reactions II 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-5754 4-hydroxybenzoate biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-6938 NADH repair 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_ARGSPECAT-PWY spermine biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-7219 adenosine ribonucleotides de novo biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-7299 progesterone biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_HOMOCYSDEGR-PWY cysteine biosynthesis/homocysteine degradation (trans-sulfuration) 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-5754 4-hydroxybenzoate biosynthesis I (eukaryotes) 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-4101 sorbitol degradation I 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-7112 4-hydroxy-2-nonenal detoxification 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-7306 estradiol biosynthesis II 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-7299 progesterone biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY66-421 homocarnosine biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-5766 L-glutamate degradation X 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-6173 histamine biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY66-241 bupropion degradation 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_GLUTAMATE-SYN2-PWY glutamate biosynthesis/degradation 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY66-420 carnosine biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_GLUTAMATE-SYN2-PWY L-glutamate biosynthesis II 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_HISHP-PWY L-histidine degradation VI 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_ARGSPECAT-PWY spermine biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_ALANINE-DEG3-PWY L-alanine degradation III 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-6938 NADH repair 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY66-426 hydrogen sulfide biosynthesis (trans-sulfuration) 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY6666-1 anandamide degradation 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY66-420 carnosine biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-6535 4-aminobutyrate degradation 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-5172 acetyl-CoA biosynthesis III (from citrate) 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-6173 histamine biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-6481 L-dopachrome biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-5329 L-cysteine degradation II 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_GLUT-REDOX-PWY glutathione redox reactions II 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-5886 4-hydroxyphenylpyruvate biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY0-1313 acetate conversion to acetyl-CoA 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-6377 alpha-tocopherol degradation 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_ALANINE-DEG3-PWY alanine biosynthesis/degradation 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-6134 L-tyrosine biosynthesis IV 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-5269 cardiolipin biosynthesis II 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-5172 acetyl-CoA biosynthesis from citrate 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-6481 L-dopachrome biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-7435 mucin core 3 and core 4 O-glycosylation 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-6241 thyroid hormone biosynthesis 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-6535 4-aminobutanoate degradation I 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-6334 L-dopa degradation 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-2161B glutamate removal from folates 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 META_PWY-6133 (S)-reticuline biosynthesis II 1.0000000000004 3.97459842815806e-13 1 0 0 396 907 HUMAN_PWY-4921 protein citrullination 1.00000000000229 2.28853047623545e-12 4 0 0 396 907 HUMAN_PWY-7112 4-hydroxy-2-nonenal detoxification 1.00000000000229 2.28853047623545e-12 4 0 0 396 907 META_PWY-6030 serotonin and melatonin biosynthesis 1.00000000000667 6.66528290893531e-12 5 0 0 396 907 HUMAN_PWY66-375 leukotriene biosynthesis 1.00000000000667 6.66528290893531e-12 5 0 0 396 907 META_PWY66-375 leukotriene biosynthesis 1.00000000000667 6.66528290893531e-12 5 0 0 396 907 HUMAN_PWY-6030 serotonin and melatonin biosynthesis 1.00000000000667 6.66528290893531e-12 5 0 0 396 907 META_PWY66-201 nicotine degradation IV 1.00000000000667 6.66528290893531e-12 5 0 0 396 907 META_PWY-4921 protein citrullination 1.00000000000667 6.66528290893531e-12 5 0 0 396 907 META_PWY66-378 androgen biosynthesis 1.00000000001029 1.02936695625666e-11 6 0 0 396 907 HUMAN_PWY66-378 androgen biosynthesis 1.00000000001029 1.02936695625666e-11 6 0 0 396 907 HUMAN_PWY-7455 allopregnanolone biosynthesis 1.00000000001029 1.02936695625666e-11 6 0 0 396 907 META_PWY-7455 allopregnanolone biosynthesis 1.00000000001029 1.02936695625666e-11 6 0 0 396 907 META_PWY-6872 retinoate biosynthesis I 1.00000000001346 1.34583832793467e-11 7 0 0 396 907 HUMAN_PWY-6872 retinoate biosynthesis I 1.00000000001531 1.53120988111155e-11 8 0 0 396 907 META_PWY-7305 superpathway of steroid hormone biosynthesis 1.00000000002126 2.1261313795152e-11 11 0 0 396 907