TermID	Term	Enrichment	logP	Genes in Term	Target Genes in Term	Fraction of Targets in Term	Total Target Genes	Total Genes	Entrez Gene IDs	Gene Symbols
hsa03010	Ribosome	5.20498168757447e-15	-32.8891602110873	133	93	0.0365709791584742	2543	6908	6181,6235,124995,6156,6193,51263,9801,6135,6218,6147,6217,6134,6194,6168,6227,6222,51121,6207,11224,7311,6133,6230,6182,6169,6142,6232,4736,63931,64928,6203,3921,55052,54460,51069,6165,10573,6233,6208,51264,6176,9045,6173,6146,6188,51021,6231,6122,6202,6224,6209,51373,6187,51116,29093,6138,6125,6164,64963,6137,51187,6234,9349,6139,6205,6155,51023,6183,6143,219927,29088,6228,6154,6166,6171,6204,6132,6129,55173,6175,6189,51081,64979,51318,25873,6130,6136,6210,6158,9553,6124,6206,6152,11222	RPLP2,RPS29,MRPL10,RPL30,RPS5,MRPL30,MRPL19,RPL11,RPS17,RPL23A,RPS16,RPL10,RPS6,RPL37A,RPS21,RPS18,RPL26L1,RPS13,RPL35,UBA52,RPL9,RPS25,MRPL12,RPL38,RPL18A,RPS27,RPL10A,MRPS14,MRPL14,RPS9,RPSA,MRPL20,MRPS21,MRPL2,RPL35A,MRPL28,RPS27A,RPS14,MRPL27,RPLP1,RPL14,RPL36A,RPL22,RPS3,MRPS16,RPS26,RPL3,RPS8,RPS20,RPS15,MRPS17,RPS2,MRPS2,MRPL22,RPL15,RPL5,RPL34,MRPS11,RPL13,RSL24D1,RPS28,RPL23,RPL17,RPS11,RPL27,MRPS18C,MRPS12,RPL19,MRPL21,MRPL15,RPS23,RPL26,RPL36AL,RPL41,RPS10,RPL8,RPL7,MRPS10,RPLP0,RPS3A,MRPS7,MRPL36,MRPL35,RPL36,RPL7A,RPL12,RPS15A,RPL28,MRPL33,RPL4,RPS12,RPL24,MRPL3
ko03010	Ribosome	5.20498168757447e-15	-32.8891602110873	133	93	0.0365709791584742	2543	6908	6181,6235,124995,6156,6193,51263,9801,6135,6218,6147,6217,6134,6194,6168,6227,51121,6222,6207,11224,7311,6133,6230,6169,6182,6142,6232,4736,63931,64928,6203,3921,55052,54460,10573,51069,6165,6233,6208,51264,6176,9045,6173,6146,6188,51021,6231,6122,6202,6224,6209,6187,51373,51116,29093,6138,6125,6164,64963,6137,51187,6234,9349,6139,6205,6155,6183,51023,6143,219927,29088,6228,6154,6166,6129,6132,6171,6204,55173,6175,6189,51081,64979,51318,25873,6130,6136,6210,6158,9553,6124,6152,6206,11222	RPLP2,RPS29,MRPL10,RPL30,RPS5,MRPL30,MRPL19,RPL11,RPS17,RPL23A,RPS16,RPL10,RPS6,RPL37A,RPS21,RPL26L1,RPS18,RPS13,RPL35,UBA52,RPL9,RPS25,RPL38,MRPL12,RPL18A,RPS27,RPL10A,MRPS14,MRPL14,RPS9,RPSA,MRPL20,MRPS21,MRPL28,MRPL2,RPL35A,RPS27A,RPS14,MRPL27,RPLP1,RPL14,RPL36A,RPL22,RPS3,MRPS16,RPS26,RPL3,RPS8,RPS20,RPS15,RPS2,MRPS17,MRPS2,MRPL22,RPL15,RPL5,RPL34,MRPS11,RPL13,RSL24D1,RPS28,RPL23,RPL17,RPS11,RPL27,MRPS12,MRPS18C,RPL19,MRPL21,MRPL15,RPS23,RPL26,RPL36AL,RPL7,RPL8,RPL41,RPS10,MRPS10,RPLP0,RPS3A,MRPS7,MRPL36,MRPL35,RPL36,RPL7A,RPL12,RPS15A,RPL28,MRPL33,RPL4,RPL24,RPS12,MRPL3
hsa04141	Protein processing in endoplasmic reticulum	2.49124963438104e-13	-29.020821763139	168	108	0.0424695241840346	2543	6908	5599,5071,4287,5589,5611,7841,9451,55757,8454,29978,821,10961,3303,10134,5886,6745,81567,5610,56681,56605,9695,5034,5887,51619,7321,3998,10130,23471,55176,10802,578,10484,468,9978,3326,118424,10299,55741,3305,29927,1650,64215,51009,7466,2081,6747,10477,22824,55768,8720,823,573,7323,10808,6396,80331,1388,9871,10905,7186,3300,7095,2923,440275,3337,56886,9532,11231,6748,10483,9601,824,811,1603,9632,6238,5601,581,51465,3320,201595,7327,51360,10113,7353,5609,80700,30001,80267,10525,6746,84447,9709,7324,3304,51128,10273,22872,10427,23640,23645,7494,7322,1965,4217,10294,4780,1649	MAPK8,PARK2,ATXN3,PRKCSH,DNAJC3,MOGS,EIF2AK3,UGGT2,CUL1,UBQLN2,CANX,ERP29,HSPA1A,BCAP31,RAD23A,SSR1,TXNDC5,EIF2AK2,SAR1A,ERO1B,EDEM1,P4HB,RAD23B,UBE2D4,UBE2D1,LMAN1,PDIA6,TRAM1,SEC61A2,SEC24A,BAK1,SEC23A,ATF4,RBX1,HSP90AB1,UBE2J2,MARCH6,EDEM2,HSPA1L,SEC61A1,DDOST,DNAJC1,DERL2,WFS1,ERN1,SSR3,UBE2E3,HSPA4L,NGLY1,MBTPS1,CAPN1,BAG1,UBE2D3,HSPH1,SEC13,DNAJC5,ATF6B,SEC24D,MAN1A2,TRAF2,DNAJB2,SEC62,PDIA3,EIF2AK4,DNAJB1,UGGT1,BAG2,SEC63,SSR4,SEC23B,PDIA4,CAPN2,CALR,DAD1,SEC24C,RRBP1,MAPK9,BAX,UBE2J1,HSP90AA1,STT3B,UBE2G2,MBTPS2,PREB,UFD1L,MAP2K7,UBXN6,ERO1A,EDEM3,HYOU1,SSR2,SYVN1,HERPUD1,UBE2E1,HSPA1B,SAR1B,STUB1,SEC31A,SEC24B,HSPBP1,PPP1R15A,XBP1,UBE2D2,EIF2S1,MAP3K5,DNAJA2,NFE2L2,DDIT3
ko04141	Protein processing in endoplasmic reticulum	2.49124963438104e-13	-29.020821763139	168	108	0.0424695241840346	2543	6908	5599,5071,4287,5589,5611,7841,9451,55757,8454,29978,821,10961,3303,10134,5886,6745,81567,5610,56681,56605,9695,5034,5887,51619,7321,3998,10130,23471,55176,10802,578,10484,468,9978,3326,118424,10299,55741,3305,29927,1650,64215,51009,7466,2081,6747,10477,22824,55768,8720,823,573,7323,10808,6396,80331,1388,9871,10905,7186,3300,7095,2923,440275,3337,56886,9532,11231,6748,10483,9601,824,811,1603,9632,6238,5601,581,51465,3320,201595,7327,51360,10113,7353,5609,80700,30001,80267,10525,6746,84447,9709,7324,3304,51128,10273,22872,10427,23640,23645,7494,7322,1965,4217,10294,4780,1649	MAPK8,PARK2,ATXN3,PRKCSH,DNAJC3,MOGS,EIF2AK3,UGGT2,CUL1,UBQLN2,CANX,ERP29,HSPA1A,BCAP31,RAD23A,SSR1,TXNDC5,EIF2AK2,SAR1A,ERO1B,EDEM1,P4HB,RAD23B,UBE2D4,UBE2D1,LMAN1,PDIA6,TRAM1,SEC61A2,SEC24A,BAK1,SEC23A,ATF4,RBX1,HSP90AB1,UBE2J2,MARCH6,EDEM2,HSPA1L,SEC61A1,DDOST,DNAJC1,DERL2,WFS1,ERN1,SSR3,UBE2E3,HSPA4L,NGLY1,MBTPS1,CAPN1,BAG1,UBE2D3,HSPH1,SEC13,DNAJC5,ATF6B,SEC24D,MAN1A2,TRAF2,DNAJB2,SEC62,PDIA3,EIF2AK4,DNAJB1,UGGT1,BAG2,SEC63,SSR4,SEC23B,PDIA4,CAPN2,CALR,DAD1,SEC24C,RRBP1,MAPK9,BAX,UBE2J1,HSP90AA1,STT3B,UBE2G2,MBTPS2,PREB,UFD1L,MAP2K7,UBXN6,ERO1A,EDEM3,HYOU1,SSR2,SYVN1,HERPUD1,UBE2E1,HSPA1B,SAR1B,STUB1,SEC31A,SEC24B,HSPBP1,PPP1R15A,XBP1,UBE2D2,EIF2S1,MAP3K5,DNAJA2,NFE2L2,DDIT3
hsa04110	Cell cycle	1.77936544951826e-12	-27.0547643042166	124	84	0.033031852143138	2543	6908	2033,1875,9232,8454,1026,7531,891,898,1387,1031,64682,7465,4193,5111,890,8555,51343,51529,10393,8379,1027,51434,1032,1021,7709,9978,991,10735,1871,10971,990,9088,8697,995,983,7532,4088,8318,4087,1874,4616,4085,8243,2932,3065,7029,1870,4089,4172,3066,1030,51433,4175,1028,10912,10926,1111,10459,25,9126,8317,7272,896,699,23595,993,4999,10274,5591,6502,29882,1647,5000,996,7027,5001,7534,8556,7533,9133,9700,2810,1029,23594	EP300,E2F5,PTTG1,CUL1,CDKN1A,YWHAE,CCNB1,CCNE1,CREBBP,CDKN2C,ANAPC1,WEE1,MDM2,PCNA,CCNA2,CDC14B,FZR1,ANAPC11,ANAPC10,MAD1L1,CDKN1B,ANAPC7,CDKN2D,CDK6,ZBTB17,RBX1,CDC20,STAG2,E2F3,YWHAQ,CDC6,PKMYT1,CDC23,CDC25C,CDK1,YWHAG,SMAD3,CDC45,SMAD2,E2F4,GADD45B,MAD2L1,SMC1A,GSK3B,HDAC1,TFDP2,E2F2,SMAD4,MCM3,HDAC2,CDKN2B,ANAPC5,MCM6,CDKN1C,GADD45G,DBF4,CHEK1,MAD2L2,ABL1,SMC3,CDC7,TTK,CCND3,BUB1,ORC3,CDC25A,ORC2,STAG1,PRKDC,SKP2,ANAPC2,GADD45A,ORC4,CDC27,TFDP1,ORC5,YWHAZ,CDC14A,YWHAH,CCNB2,ESPL1,SFN,CDKN2A,ORC6
ko04110	Cell cycle	1.77936544951826e-12	-27.0547643042166	124	84	0.033031852143138	2543	6908	2033,1875,9232,8454,1026,7531,891,898,1387,1031,64682,7465,4193,5111,890,8555,51343,51529,10393,8379,1027,51434,1032,1021,7709,9978,991,10735,1871,10971,990,9088,8697,995,983,7532,4088,8318,4087,1874,4616,4085,8243,2932,3065,7029,1870,4089,4172,3066,1030,51433,4175,1028,10912,10926,1111,10459,25,9126,8317,7272,896,699,23595,993,4999,10274,5591,6502,29882,1647,5000,996,7027,5001,7534,8556,7533,9133,9700,2810,1029,23594	EP300,E2F5,PTTG1,CUL1,CDKN1A,YWHAE,CCNB1,CCNE1,CREBBP,CDKN2C,ANAPC1,WEE1,MDM2,PCNA,CCNA2,CDC14B,FZR1,ANAPC11,ANAPC10,MAD1L1,CDKN1B,ANAPC7,CDKN2D,CDK6,ZBTB17,RBX1,CDC20,STAG2,E2F3,YWHAQ,CDC6,PKMYT1,CDC23,CDC25C,CDK1,YWHAG,SMAD3,CDC45,SMAD2,E2F4,GADD45B,MAD2L1,SMC1A,GSK3B,HDAC1,TFDP2,E2F2,SMAD4,MCM3,HDAC2,CDKN2B,ANAPC5,MCM6,CDKN1C,GADD45G,DBF4,CHEK1,MAD2L2,ABL1,SMC3,CDC7,TTK,CCND3,BUB1,ORC3,CDC25A,ORC2,STAG1,PRKDC,SKP2,ANAPC2,GADD45A,ORC4,CDC27,TFDP1,ORC5,YWHAZ,CDC14A,YWHAH,CCNB2,ESPL1,SFN,CDKN2A,ORC6
ko03040	Spliceosome	2.47401173133419e-11	-24.4225950071265	132	86	0.0338183248132127	2543	6908	9092,9410,9984,10523,5356,7919,6636,10713,51645,6635,5093,153527,3303,220988,83443,10992,55110,6427,84844,10286,9775,6429,9716,3192,10291,6629,23020,10450,51690,51340,3183,10907,11017,1665,3305,9879,8449,11157,7307,23350,10084,9128,6637,10285,6627,55119,10594,51362,25949,144983,84950,57461,25804,22985,22938,151903,56259,23658,55696,9343,8896,24148,4670,29896,51639,6430,10915,199746,8175,6626,3304,9416,23450,22827,25766,58517,57187,10569,3190,57819,22916,1655,6428,10465,6633,51503	SART1,SNRNP40,THOC1,CHERP,PLRG1,DDX39B,SNRPF,USP39,PPIL1,SNRPE,PCBP1,ZMAT2,HSPA1A,HNRNPA3,SF3B5,SF3B2,MAGOHB,SRSF2,PHF5A,BCAS2,EIF4A3,SRSF4,AQR,HNRNPU,SF3A1,SNRPB2,SNRNP200,PPIE,LSM7,CRNKL1,HNRNPC,TXNL4A,SNRNP27,DHX15,HSPA1L,DDX46,DHX16,LSM6,U2AF1,U2SURP,PQBP1,PRPF4,SNRPG,SMNDC1,SNRPA1,PRPF38B,PRPF8,CDC40,SYF2,HNRNPA1L2,PRPF38A,ISY1,LSM4,ACIN1,SNW1,CCDC12,CTNNBL1,LSM5,RBM22,EFTUD2,BUD31,PRPF6,HNRNPM,TRA2A,SF3B6,SRSF5,TCERG1,U2AF1L4,SF3A2,SNRPA,HSPA1B,DDX23,SF3B3,PUF60,PRPF40B,RBM25,THOC2,SLU7,HNRNPK,LSM2,NCBP2,DDX5,SRSF3,PPIH,SNRPD2,CWC15
hsa03040	Spliceosome	2.47401173133419e-11	-24.4225950071265	132	86	0.0338183248132127	2543	6908	9092,9410,9984,10523,5356,7919,6636,10713,51645,6635,5093,153527,3303,220988,83443,10992,55110,6427,84844,10286,9775,6429,9716,3192,10291,6629,23020,10450,51690,51340,3183,10907,11017,1665,3305,9879,8449,11157,7307,23350,10084,9128,6637,10285,6627,55119,10594,51362,25949,144983,84950,57461,25804,22985,22938,151903,56259,23658,55696,9343,8896,24148,4670,29896,51639,6430,10915,199746,8175,6626,3304,9416,23450,22827,25766,58517,57187,10569,3190,57819,22916,1655,6428,10465,6633,51503	SART1,SNRNP40,THOC1,CHERP,PLRG1,DDX39B,SNRPF,USP39,PPIL1,SNRPE,PCBP1,ZMAT2,HSPA1A,HNRNPA3,SF3B5,SF3B2,MAGOHB,SRSF2,PHF5A,BCAS2,EIF4A3,SRSF4,AQR,HNRNPU,SF3A1,SNRPB2,SNRNP200,PPIE,LSM7,CRNKL1,HNRNPC,TXNL4A,SNRNP27,DHX15,HSPA1L,DDX46,DHX16,LSM6,U2AF1,U2SURP,PQBP1,PRPF4,SNRPG,SMNDC1,SNRPA1,PRPF38B,PRPF8,CDC40,SYF2,HNRNPA1L2,PRPF38A,ISY1,LSM4,ACIN1,SNW1,CCDC12,CTNNBL1,LSM5,RBM22,EFTUD2,BUD31,PRPF6,HNRNPM,TRA2A,SF3B6,SRSF5,TCERG1,U2AF1L4,SF3A2,SNRPA,HSPA1B,DDX23,SF3B3,PUF60,PRPF40B,RBM25,THOC2,SLU7,HNRNPK,LSM2,NCBP2,DDX5,SRSF3,PPIH,SNRPD2,CWC15
ko04120	Ubiquitin mediated proteolysis	1.42525483860762e-10	-22.6715002980981	137	87	0.0342115611482501	2543	6908	5071,23291,7317,57448,55284,8450,55585,65264,8454,10055,329,51366,55120,64682,4193,8651,10054,6477,51343,51529,10393,51619,23295,26091,51434,7321,26259,1161,330,6923,9978,83737,991,8452,118424,672,8697,9021,10401,10477,57154,7334,51588,7323,51433,9320,9886,9039,26272,9354,11060,7337,92912,9246,55070,10075,23759,51465,11059,89910,9690,54926,7327,4214,1643,7332,9616,6502,7328,29882,6921,84447,64750,4591,55236,7324,64326,10273,997,996,8925,8453,7322,9063,27338,11065,1642	PARK2,FBXW11,UBA1,BIRC6,UBE2W,CUL4B,UBE2Q1,UBE2Z,CUL1,SAE1,BIRC2,UBR5,FANCL,ANAPC1,MDM2,SOCS1,UBA2,SIAH1,FZR1,ANAPC11,ANAPC10,UBE2D4,MGRN1,HERC4,ANAPC7,UBE2D1,FBXW8,ERCC8,BIRC3,TCEB2,RBX1,ITCH,CDC20,CUL3,UBE2J2,BRCA1,CDC23,SOCS3,PIAS3,UBE2E3,SMURF1,UBE2N,PIAS4,UBE2D3,ANAPC5,TRIP12,RHOBTB1,UBA3,FBXO4,UBE4A,WWP2,UBE3A,UBE2Q2,UBE2L6,DET1,HUWE1,PPIL2,UBE2J1,WWP1,UBE3B,UBE3C,UBE2R2,UBE2G2,MAP3K1,DDB2,UBE2L3,RNF7,SKP2,UBE2H,ANAPC2,TCEB1,SYVN1,SMURF2,TRIM37,UBA6,UBE2E1,RFWD2,STUB1,CDC34,CDC27,HERC1,CUL2,UBE2D2,PIAS2,UBE2S,UBE2C,DDB1
hsa04120	Ubiquitin mediated proteolysis	1.42525483860762e-10	-22.6715002980981	137	87	0.0342115611482501	2543	6908	5071,23291,7317,57448,55284,8450,55585,65264,8454,10055,329,51366,55120,64682,4193,8651,10054,6477,51343,51529,10393,51619,23295,26091,51434,7321,26259,1161,330,6923,9978,83737,991,8452,118424,672,8697,9021,10401,10477,57154,7334,51588,7323,51433,9320,9886,9039,26272,9354,11060,7337,92912,9246,55070,10075,23759,51465,11059,89910,9690,54926,7327,4214,1643,7332,9616,6502,7328,29882,6921,84447,64750,4591,55236,7324,64326,10273,997,996,8925,8453,7322,9063,27338,11065,1642	PARK2,FBXW11,UBA1,BIRC6,UBE2W,CUL4B,UBE2Q1,UBE2Z,CUL1,SAE1,BIRC2,UBR5,FANCL,ANAPC1,MDM2,SOCS1,UBA2,SIAH1,FZR1,ANAPC11,ANAPC10,UBE2D4,MGRN1,HERC4,ANAPC7,UBE2D1,FBXW8,ERCC8,BIRC3,TCEB2,RBX1,ITCH,CDC20,CUL3,UBE2J2,BRCA1,CDC23,SOCS3,PIAS3,UBE2E3,SMURF1,UBE2N,PIAS4,UBE2D3,ANAPC5,TRIP12,RHOBTB1,UBA3,FBXO4,UBE4A,WWP2,UBE3A,UBE2Q2,UBE2L6,DET1,HUWE1,PPIL2,UBE2J1,WWP1,UBE3B,UBE3C,UBE2R2,UBE2G2,MAP3K1,DDB2,UBE2L3,RNF7,SKP2,UBE2H,ANAPC2,TCEB1,SYVN1,SMURF2,TRIM37,UBA6,UBE2E1,RFWD2,STUB1,CDC34,CDC27,HERC1,CUL2,UBE2D2,PIAS2,UBE2S,UBE2C,DDB1
ko03018	RNA degradation	9.91328302659439e-09	-18.4293902592496	77	53	0.0208415257569799	2543	6908	2026,23019,51010,255967,9337,196513,25804,29883,5073,9924,4849,80153,23016,23658,1656,5211,2027,10766,56915,9652,22803,54512,3329,27257,84186,4850,26986,10200,6499,23404,10438,118460,80349,23517,7832,51690,23644,5393,219988,5394,4848,9125,131870,694,11157,64282,57819,57472,54464,10140,170506,5214,115752	ENO2,CNOT1,EXOSC3,PAN3,CNOT8,DCP1B,LSM4,CNOT7,PARN,PAN2,CNOT3,EDC3,EXOSC7,LSM5,DDX6,PFKL,ENO3,TOB2,EXOSC5,TTC37,XRN2,EXOSC4,HSPD1,LSM1,ZCCHC7,CNOT4,PABPC1,MPHOSPH6,SKIV2L,EXOSC2,C1D,EXOSC6,WDR61,SKIV2L2,BTG2,LSM7,EDC4,EXOSC9,PATL1,EXOSC10,CNOT2,RQCD1,NUDT16,BTG1,LSM6,PAPD5,LSM2,CNOT6,XRN1,TOB1,DHX36,PFKP,DIS3L
hsa03018	RNA degradation	9.91328302659439e-09	-18.4293902592496	77	53	0.0208415257569799	2543	6908	2026,23019,51010,255967,9337,196513,25804,29883,5073,9924,4849,80153,23016,23658,1656,5211,2027,10766,56915,9652,22803,54512,3329,27257,84186,4850,26986,10200,6499,23404,10438,118460,80349,23517,7832,51690,23644,5393,219988,5394,4848,9125,131870,694,11157,64282,57819,57472,54464,10140,170506,5214,115752	ENO2,CNOT1,EXOSC3,PAN3,CNOT8,DCP1B,LSM4,CNOT7,PARN,PAN2,CNOT3,EDC3,EXOSC7,LSM5,DDX6,PFKL,ENO3,TOB2,EXOSC5,TTC37,XRN2,EXOSC4,HSPD1,LSM1,ZCCHC7,CNOT4,PABPC1,MPHOSPH6,SKIV2L,EXOSC2,C1D,EXOSC6,WDR61,SKIV2L2,BTG2,LSM7,EDC4,EXOSC9,PATL1,EXOSC10,CNOT2,RQCD1,NUDT16,BTG1,LSM6,PAPD5,LSM2,CNOT6,XRN1,TOB1,DHX36,PFKP,DIS3L
hsa00240	Pyrimidine metabolism	7.628790523055e-08	-16.3887514272033	104	65	0.0255603617774282	2543	6908	955,51251,5424,51728,114112,1890,9583,1854,4831,30833,54107,55703,51727,1806,30834,10587,1841,5436,5441,3704,54963,7378,5433,6241,4832,5557,5432,4830,124583,7298,5440,171568,6240,1723,7084,79077,957,56474,4833,84172,56953,64425,10621,7296,5438,4860,5558,10201,5422,84265,1635,10714,318,221830,5430,11128,29922,5427,5426,50484,1633,5434,7372,9533,5425	ENTPD6,NT5C3A,POLD1,POLR3K,TXNRD3,TYMP,ENTPD4,DUT,NME2,NT5C,POLE3,POLR3B,CMPK1,DPYD,ZNRD1,TXNRD2,DTYMK,POLR2G,POLR2L,ITPA,UCKL1,UPP1,POLR2D,RRM2,NME3,PRIM1,POLR2C,NME1,CANT1,TYMS,POLR2K,POLR3H,RRM1,DHODH,TK2,DCTPP1,ENTPD5,CTPS2,NME4,POLR1B,NT5M,POLR1E,POLR3F,TXNRD1,POLR2I,PNP,PRIM2,NME6,POLA1,POLR3GL,DCTD,POLD3,NUDT2,TWISTNB,POLR2A,POLR3A,NME7,POLE2,POLE,RRM2B,DCK,POLR2E,UMPS,POLR1C,POLD2
ko00240	Pyrimidine metabolism	7.628790523055e-08	-16.3887514272033	104	65	0.0255603617774282	2543	6908	955,51251,5424,51728,114112,1890,9583,1854,4831,30833,51727,54107,55703,1806,30834,10587,1841,5436,5441,3704,54963,7378,5433,6241,4832,5557,5432,4830,124583,7298,5440,171568,6240,1723,7084,79077,957,56474,4833,84172,56953,64425,10621,7296,5438,4860,5558,10201,5422,84265,1635,10714,318,221830,11128,5430,29922,5427,5426,50484,1633,5434,7372,9533,5425	ENTPD6,NT5C3A,POLD1,POLR3K,TXNRD3,TYMP,ENTPD4,DUT,NME2,NT5C,CMPK1,POLE3,POLR3B,DPYD,ZNRD1,TXNRD2,DTYMK,POLR2G,POLR2L,ITPA,UCKL1,UPP1,POLR2D,RRM2,NME3,PRIM1,POLR2C,NME1,CANT1,TYMS,POLR2K,POLR3H,RRM1,DHODH,TK2,DCTPP1,ENTPD5,CTPS2,NME4,POLR1B,NT5M,POLR1E,POLR3F,TXNRD1,POLR2I,PNP,PRIM2,NME6,POLA1,POLR3GL,DCTD,POLD3,NUDT2,TWISTNB,POLR3A,POLR2A,NME7,POLE2,POLE,RRM2B,DCK,POLR2E,UMPS,POLR1C,POLD2
ko04932	Non-alcoholic fatty liver disease (NAFLD)	1.37122945088311e-07	-15.8023879041456	147	85	0.0334250884781754	2543	6908	5599,836,4698,4712,7381,5565,29796,5879,6256,4711,9451,4706,1050,51079,4709,3551,5296,7385,4714,8503,4715,4731,4700,841,4705,5970,4720,4704,4717,468,1350,2931,207,27089,208,83737,5571,9021,6392,8660,2081,4694,4296,2932,51094,7388,4713,4702,1329,4729,4719,6391,7186,5562,79602,4697,1327,374291,4724,6945,4723,4695,4710,1337,5601,581,51085,1349,10975,10018,4696,55967,5295,5465,7384,51422,3643,840,3569,9167,7494,1351,1965,4217,1649	MAPK8,CASP3,NDUFA5,NDUFB6,UQCRB,PRKAB2,UQCR10,RAC1,RXRA,NDUFB5,EIF2AK3,NDUFAB1,CEBPA,NDUFA13,NDUFB3,IKBKB,PIK3R2,UQCRC2,NDUFB8,PIK3R3,NDUFB9,NDUFV3,NDUFA6,CASP8,NDUFA10,RELA,NDUFS2,NDUFA9,NDUFC1,ATF4,COX7C,GSK3A,AKT1,UQCRQ,AKT2,ITCH,PRKAG1,SOCS3,SDHD,IRS2,ERN1,NDUFA1,MAP3K11,GSK3B,ADIPOR1,UQCRH,NDUFB7,NDUFA8,COX5B,NDUFV2,NDUFS1,SDHC,TRAF2,PRKAA1,ADIPOR2,NDUFA4,COX4I1,NDUFS7,NDUFS4,MLX,NDUFV1,NDUFA2,NDUFB4,COX6A1,MAPK9,BAX,MLXIPL,COX7B,UQCR11,BCL2L11,NDUFA3,NDUFA12,PIK3R1,PPARA,UQCRC1,PRKAG2,INSR,CASP7,IL6,COX7A2L,XBP1,COX8A,EIF2S1,MAP3K5,DDIT3
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	1.37122945088311e-07	-15.8023879041456	147	85	0.0334250884781754	2543	6908	5599,836,4698,4712,7381,5565,29796,5879,6256,4711,9451,4706,1050,51079,4709,3551,5296,7385,4714,8503,4715,4731,4700,841,4705,5970,4720,4704,4717,468,1350,2931,207,27089,208,83737,5571,9021,6392,8660,2081,4694,4296,2932,51094,7388,4713,4702,1329,4729,4719,6391,7186,5562,79602,4697,1327,374291,4724,6945,4723,4695,4710,1337,5601,581,51085,1349,10975,10018,4696,55967,5295,5465,7384,51422,3643,840,3569,9167,7494,1351,1965,4217,1649	MAPK8,CASP3,NDUFA5,NDUFB6,UQCRB,PRKAB2,UQCR10,RAC1,RXRA,NDUFB5,EIF2AK3,NDUFAB1,CEBPA,NDUFA13,NDUFB3,IKBKB,PIK3R2,UQCRC2,NDUFB8,PIK3R3,NDUFB9,NDUFV3,NDUFA6,CASP8,NDUFA10,RELA,NDUFS2,NDUFA9,NDUFC1,ATF4,COX7C,GSK3A,AKT1,UQCRQ,AKT2,ITCH,PRKAG1,SOCS3,SDHD,IRS2,ERN1,NDUFA1,MAP3K11,GSK3B,ADIPOR1,UQCRH,NDUFB7,NDUFA8,COX5B,NDUFV2,NDUFS1,SDHC,TRAF2,PRKAA1,ADIPOR2,NDUFA4,COX4I1,NDUFS7,NDUFS4,MLX,NDUFV1,NDUFA2,NDUFB4,COX6A1,MAPK9,BAX,MLXIPL,COX7B,UQCR11,BCL2L11,NDUFA3,NDUFA12,PIK3R1,PPARA,UQCRC1,PRKAG2,INSR,CASP7,IL6,COX7A2L,XBP1,COX8A,EIF2S1,MAP3K5,DDIT3
hsa01130	Biosynthesis of antibiotics	5.44981024442375e-07	-14.4225148604262	210	112	0.044042469524184	2543	6908	9945,113675,9986,7360,8802,122481,4191,3418,2639,4942,9453,587,3422,51166,2806,65263,230,9061,1431,3032,4831,10449,8801,6888,132158,1491,2731,5160,2597,25796,3419,80201,51005,3417,4953,1743,4832,10269,5831,6392,10327,203,50,4047,39,4830,2539,226,91373,5723,7167,5214,22934,1962,55276,2026,593,6391,102157402,435,3028,51477,6120,30,128,3157,6307,5211,471,10606,2027,5238,4833,6472,50808,5106,3101,6309,1629,224,223,3945,3156,2222,2673,271,5096,5625,5236,29968,10201,669,594,5471,50814,1892,7108,158,5315,5226,847,2339,283871,29922,2224,38,4190,5224,3098,3420,5223,2653	GFPT2,SDSL,RCE1,UGP2,SUCLG1,AK7,MDH2,IDH2,GCDH,OAT,GGPS1,BCAT2,IDI1,AADAT,GOT2,PYCRL,ALDOC,PAPSS1,CS,HADHB,NME2,ACAA2,SUCLG2,TALDO1,GLYCTK,CTH,GLDC,PDHA1,GAPDH,PGLS,IDH3A,HKDC1,AMDHD2,IDH1,ODC1,DLST,NME3,ZMPSTE24,PYCR1,SDHD,AKR1A1,AK1,ACO2,LSS,ACAT2,NME1,G6PD,ALDOA,UAP1L1,PSPH,TPI1,PFKP,RPIA,EHHADH,PGM2,ENO2,BCKDHA,SDHC,AK6,ASL,HSD17B10,ISYNA1,RPE,ACAA1,ADH5,HMGCS1,MSMO1,PFKL,ATIC,PAICS,ENO3,PGM3,NME4,SHMT2,AK3,PCK2,HK3,SC5D,DBT,ALDH3A2,ALDH9A1,LDHB,HMGCR,FDFT1,GFPT1,AMPD2,PCCB,PRODH,PGM1,PSAT1,NME6,BPGM,BCKDHB,PPAT,NSDHL,ECHS1,TM7SF2,ADSL,PKM,PGD,CAT,FNTA,PGP,NME7,FDPS,ACAT1,MDH1,PGAM2,HK1,IDH3B,PGAM1,GCSH
hsa05012	Parkinson's disease	5.54577026817021e-07	-14.4050601275996	129	75	0.0294927251278018	2543	6908	4698,5071,836,7317,4712,7381,29796,4711,4706,51079,5566,11315,4709,7385,4714,7419,4715,4731,4700,4705,4720,5567,10105,4704,4717,1350,27089,120892,842,7417,514,118424,7416,2773,515,2770,6622,6392,291,4694,7388,4713,4702,4729,1329,4719,6391,4697,1327,506,374291,4724,4723,9246,4695,4710,1337,10476,51465,10975,1349,7314,55967,2771,4696,7327,516,7332,7384,518,509,9167,1351,317,498	NDUFA5,PARK2,CASP3,UBA1,NDUFB6,UQCRB,UQCR10,NDUFB5,NDUFAB1,NDUFA13,PRKACA,PARK7,NDUFB3,UQCRC2,NDUFB8,VDAC3,NDUFB9,NDUFV3,NDUFA6,NDUFA10,NDUFS2,PRKACB,PPIF,NDUFA9,NDUFC1,COX7C,UQCRQ,LRRK2,CASP9,VDAC2,ATP5E,UBE2J2,VDAC1,GNAI3,ATP5F1,GNAI1,SNCA,SDHD,SLC25A4,NDUFA1,UQCRH,NDUFB7,NDUFA8,NDUFV2,COX5B,NDUFS1,SDHC,NDUFA4,COX4I1,ATP5B,NDUFS7,NDUFS4,NDUFV1,UBE2L6,NDUFA2,NDUFB4,COX6A1,ATP5H,UBE2J1,UQCR11,COX7B,UBB,NDUFA12,GNAI2,NDUFA3,UBE2G2,ATP5G1,UBE2L3,UQCRC1,ATP5G3,ATP5C1,COX7A2L,COX8A,APAF1,ATP5A1
ko05016	Huntington's disease	9.08496426692877e-07	-13.9114748823123	187	101	0.0397168698387731	2543	6908	2033,4698,836,4712,8218,7381,29796,6648,4711,4706,25942,51079,4709,1387,4899,7385,4714,7419,163,4715,4731,4700,841,4705,4720,10126,10105,4704,1350,4717,5436,5441,5468,27089,842,5433,7417,1742,514,7416,515,6392,5432,291,1213,4694,3065,7388,10891,4713,4702,1175,3066,4729,1329,55081,4719,1173,5440,6908,6391,1327,4697,10488,506,374291,4724,4723,4695,4710,1337,10476,51164,581,10975,1349,83544,55967,4696,6667,516,5438,23186,3092,7384,9001,6875,5430,56171,3064,518,160,509,9167,3708,1351,5434,9519,498,317,2876	EP300,NDUFA5,CASP3,NDUFB6,CLTCL1,UQCRB,UQCR10,SOD2,NDUFB5,NDUFAB1,SIN3A,NDUFA13,NDUFB3,CREBBP,NRF1,UQCRC2,NDUFB8,VDAC3,AP2B1,NDUFB9,NDUFV3,NDUFA6,CASP8,NDUFA10,NDUFS2,DNAL4,PPIF,NDUFA9,COX7C,NDUFC1,POLR2G,POLR2L,PPARG,UQCRQ,CASP9,POLR2D,VDAC2,DLG4,ATP5E,VDAC1,ATP5F1,SDHD,POLR2C,SLC25A4,CLTC,NDUFA1,HDAC1,UQCRH,PPARGC1A,NDUFB7,NDUFA8,AP2S1,HDAC2,NDUFV2,COX5B,IFT57,NDUFS1,AP2M1,POLR2K,TBP,SDHC,COX4I1,NDUFA4,CREB3,ATP5B,NDUFS7,NDUFS4,NDUFV1,NDUFA2,NDUFB4,COX6A1,ATP5H,DCTN4,BAX,UQCR11,COX7B,DNAL1,NDUFA12,NDUFA3,SP1,ATP5G1,POLR2I,RCOR1,HIP1,UQCRC1,HAP1,TAF4B,POLR2A,DNAH7,HTT,ATP5G3,AP2A1,ATP5C1,COX7A2L,ITPR1,COX8A,POLR2E,TBPL1,ATP5A1,APAF1,GPX1
hsa05016	Huntington's disease	9.08496426692877e-07	-13.9114748823123	187	101	0.0397168698387731	2543	6908	2033,4698,836,4712,8218,7381,29796,6648,4711,4706,25942,51079,4709,1387,4899,7385,4714,7419,163,4715,4731,4700,841,4705,4720,10126,10105,4704,1350,4717,5436,5441,5468,27089,842,5433,7417,1742,514,7416,515,6392,5432,291,1213,4694,3065,7388,10891,4713,4702,1175,3066,4729,1329,55081,4719,1173,5440,6908,6391,1327,4697,10488,506,374291,4724,4723,4695,4710,1337,10476,51164,581,10975,1349,83544,55967,4696,6667,516,5438,23186,3092,7384,9001,6875,5430,56171,3064,518,160,509,9167,3708,1351,5434,9519,498,317,2876	EP300,NDUFA5,CASP3,NDUFB6,CLTCL1,UQCRB,UQCR10,SOD2,NDUFB5,NDUFAB1,SIN3A,NDUFA13,NDUFB3,CREBBP,NRF1,UQCRC2,NDUFB8,VDAC3,AP2B1,NDUFB9,NDUFV3,NDUFA6,CASP8,NDUFA10,NDUFS2,DNAL4,PPIF,NDUFA9,COX7C,NDUFC1,POLR2G,POLR2L,PPARG,UQCRQ,CASP9,POLR2D,VDAC2,DLG4,ATP5E,VDAC1,ATP5F1,SDHD,POLR2C,SLC25A4,CLTC,NDUFA1,HDAC1,UQCRH,PPARGC1A,NDUFB7,NDUFA8,AP2S1,HDAC2,NDUFV2,COX5B,IFT57,NDUFS1,AP2M1,POLR2K,TBP,SDHC,COX4I1,NDUFA4,CREB3,ATP5B,NDUFS7,NDUFS4,NDUFV1,NDUFA2,NDUFB4,COX6A1,ATP5H,DCTN4,BAX,UQCR11,COX7B,DNAL1,NDUFA12,NDUFA3,SP1,ATP5G1,POLR2I,RCOR1,HIP1,UQCRC1,HAP1,TAF4B,POLR2A,DNAH7,HTT,ATP5G3,AP2A1,ATP5C1,COX7A2L,ITPR1,COX8A,POLR2E,TBPL1,ATP5A1,APAF1,GPX1
hsa03050	Proteasome	1.28986968383414e-06	-13.5609693649772	44	32	0.0125835627211954	2543	6908	5689,5693,5692,5683,5702,5695,5713,5720,51371,5710,5685,9491,5691,5704,5708,5687,5696,5719,5706,5709,7979,5688,5701,23198,10213,5690,5717,9861,5705,5700,5686,5694	PSMB1,PSMB5,PSMB4,PSMA2,PSMC3,PSMB7,PSMD7,PSME1,POMP,PSMD4,PSMA4,PSMF1,PSMB3,PSMC4,PSMD2,PSMA6,PSMB8,PSMD13,PSMC6,PSMD3,SHFM1,PSMA7,PSMC2,PSME4,PSMD14,PSMB2,PSMD11,PSMD6,PSMC5,PSMC1,PSMA5,PSMB6
ko03050	Proteasome	1.28986968383414e-06	-13.5609693649772	44	32	0.0125835627211954	2543	6908	5689,5693,5692,5683,5702,5695,5713,5720,51371,5710,9491,5685,5691,5704,5708,5687,5696,5719,5706,5709,5688,7979,5701,10213,23198,5690,5717,9861,5705,5700,5686,5694	PSMB1,PSMB5,PSMB4,PSMA2,PSMC3,PSMB7,PSMD7,PSME1,POMP,PSMD4,PSMF1,PSMA4,PSMB3,PSMC4,PSMD2,PSMA6,PSMB8,PSMD13,PSMC6,PSMD3,PSMA7,SHFM1,PSMC2,PSMD14,PSME4,PSMB2,PSMD11,PSMD6,PSMC5,PSMC1,PSMA5,PSMB6
hsa00190	Oxidative phosphorylation	2.72324645751996e-06	-12.8136858388128	120	69	0.0271333071175777	2543	6908	4698,4712,7381,523,29796,537,4711,521,4706,51079,4709,7385,4714,4715,4731,4700,529,4705,4720,9550,4704,4717,1350,27089,1353,535,514,515,6392,10312,4694,7388,527,4713,4702,8992,4729,1329,4719,6391,4697,1327,506,374291,4724,4723,4695,4710,10476,1337,23545,10975,1349,51606,55967,4696,9114,516,7384,64077,9551,10063,51382,518,509,9167,1351,498,528	NDUFA5,NDUFB6,UQCRB,ATP6V1A,UQCR10,ATP6AP1,NDUFB5,ATP5I,NDUFAB1,NDUFA13,NDUFB3,UQCRC2,NDUFB8,NDUFB9,NDUFV3,NDUFA6,ATP6V1E1,NDUFA10,NDUFS2,ATP6V1G1,NDUFA9,NDUFC1,COX7C,UQCRQ,COX11,ATP6V0A1,ATP5E,ATP5F1,SDHD,TCIRG1,NDUFA1,UQCRH,ATP6V0C,NDUFB7,NDUFA8,ATP6V0E1,NDUFV2,COX5B,NDUFS1,SDHC,NDUFA4,COX4I1,ATP5B,NDUFS7,NDUFS4,NDUFV1,NDUFA2,NDUFB4,ATP5H,COX6A1,ATP6V0A2,UQCR11,COX7B,ATP6V1H,NDUFA12,NDUFA3,ATP6V0D1,ATP5G1,UQCRC1,LHPP,ATP5J2,COX17,ATP6V1D,ATP5G3,ATP5C1,COX7A2L,COX8A,ATP5A1,ATP6V1C1
ko00190	Oxidative phosphorylation	2.72324645751996e-06	-12.8136858388128	120	69	0.0271333071175777	2543	6908	4698,4712,523,7381,29796,4711,537,4706,521,51079,4709,7385,4714,4715,4731,4700,4705,529,4720,9550,4704,1350,4717,27089,1353,535,514,6392,515,10312,4694,527,7388,4713,4702,8992,4729,1329,4719,6391,4697,1327,506,374291,4724,4723,4695,4710,10476,1337,23545,10975,1349,51606,55967,4696,9114,516,7384,64077,9551,10063,51382,518,509,9167,1351,498,528	NDUFA5,NDUFB6,ATP6V1A,UQCRB,UQCR10,NDUFB5,ATP6AP1,NDUFAB1,ATP5I,NDUFA13,NDUFB3,UQCRC2,NDUFB8,NDUFB9,NDUFV3,NDUFA6,NDUFA10,ATP6V1E1,NDUFS2,ATP6V1G1,NDUFA9,COX7C,NDUFC1,UQCRQ,COX11,ATP6V0A1,ATP5E,SDHD,ATP5F1,TCIRG1,NDUFA1,ATP6V0C,UQCRH,NDUFB7,NDUFA8,ATP6V0E1,NDUFV2,COX5B,NDUFS1,SDHC,NDUFA4,COX4I1,ATP5B,NDUFS7,NDUFS4,NDUFV1,NDUFA2,NDUFB4,ATP5H,COX6A1,ATP6V0A2,UQCR11,COX7B,ATP6V1H,NDUFA12,NDUFA3,ATP6V0D1,ATP5G1,UQCRC1,LHPP,ATP5J2,COX17,ATP6V1D,ATP5G3,ATP5C1,COX7A2L,COX8A,ATP5A1,ATP6V1C1
hsa01100	Metabolic pathways	2.95046206445917e-06	-12.733548767858	1214	517	0.203303185214314	2543	6908	2632,197258,5837,122481,10554,51251,29785,51102,30834,31,4717,7378,63917,81888,5831,7263,5432,5372,5335,226,211,527,132789,91373,3706,493911,54480,3795,5214,10005,4729,4329,171568,5428,81579,4507,8818,10476,1152,201595,10975,8694,55967,51805,178,3156,4860,594,2194,256435,3615,8394,138050,9517,51109,57494,29922,509,84649,4190,11041,85365,3073,686,2582,113675,5188,523,5048,55500,253558,4709,8611,65263,1854,64132,30833,2182,441024,9550,55650,4704,2597,5441,3419,6303,5433,535,4144,6392,9380,221,39,4830,10400,440138,154141,8566,7167,2710,6391,10905,10873,1723,506,6120,10654,5281,2937,3157,4710,10606,79868,1349,3613,3945,58478,5427,5426,5091,51,199857,138429,57678,3098,125061,6723,1591,10007,7381,56922,9197,162466,9388,2131,10423,9487,2752,51166,9061,10449,54107,4357,8612,56267,2595,84720,3417,93100,4953,1743,641371,29926,10327,515,2744,10195,4047,3251,8974,5049,200895,9942,3028,427,1327,8702,9249,80055,7084,2583,8659,56913,2356,5805,51606,5832,6309,224,10621,3612,84284,50814,2181,262,6342,7108,3295,5226,3423,10063,5980,5434,498,5337,79646,65220,5425,55349,4698,4351,7360,8802,7357,8527,64900,51079,9453,5424,1592,80146,3422,55229,10768,326625,132158,1491,7390,5436,25796,57704,1371,514,6487,50,5743,29925,6482,81889,129642,10020,353,5297,5373,128,64768,4723,1337,3155,10728,84172,5106,3101,1373,54802,1892,5498,11128,51382,9,3614,5223,112483,8310,9536,2653,317749,79717,4712,9588,51380,2639,4942,11145,8898,51728,1890,6484,55326,387787,4714,8801,4199,1806,4705,55454,2731,5160,2954,1841,124454,10026,51809,5557,137964,2531,7298,7388,8704,1329,1962,5440,79087,6480,102157402,84890,6240,54344,4697,51477,122622,374291,4724,5298,6307,1603,471,81490,23545,5833,79888,3425,66008,56052,2222,2673,5279,5625,5558,5422,1635,5315,221830,55361,51601,10797,283871,50484,1633,2643,254531,5224,7372,55748,1717,6296,51540,9374,7389,4711,3418,4706,521,80308,440,9110,230,22845,9488,51727,6888,79796,1350,53354,1353,11232,1650,253782,51181,2539,284098,4719,593,84245,56894,11019,10682,728635,79077,4695,4245,51227,4833,85007,4696,56953,55163,5096,10678,29968,8509,56895,158,29071,7384,5430,6448,36,518,8560,132,11285,54981,2180,29796,7358,537,91012,7841,1798,23382,587,2806,54928,4831,3032,7385,3373,231,8733,4731,4715,55703,4700,529,374378,4720,3704,8813,6241,25902,4122,203,10855,8942,23530,55568,4702,8992,9054,84706,80025,127281,84803,79053,435,22856,1119,5211,4952,2027,56474,8833,27034,2571,9114,64425,4522,223,516,85465,5438,10201,64802,5471,669,2629,6916,26035,2224,27349,9791,9945,4191,5283,2132,1431,8693,51074,22929,113451,144245,84693,84274,8705,54963,27089,80201,8050,4832,27010,5445,210,10312,4694,113612,56848,4713,5723,22934,8760,2026,55276,8877,30,883,253430,6472,1629,8398,271,5236,2729,133686,84265,92579,9551,10714,10588,1351,38,1719,2720,528,3420,9533,5130	GBE1,FUK,PYGM,AK7,AGPAT1,NT5C3A,CYP2S1,MECR,ZNRD1,ACACA,NDUFC1,UPP1,GALNT11,HYI,PYCR1,TST,POLR2C,PMM1,PLCG1,ALDOA,ALAS1,ATP6V0C,GNPDA2,UAP1L1,ITPKA,PHOSPHO2,CHPF2,KHK,PFKP,ACOT8,NDUFV2,ALDH6A1,POLR3H,POLG,PLA2G12A,MTAP,DPM2,ATP5H,CKB,STT3B,UQCR11,DGAT1,NDUFA12,COQ3,AGL,HMGCR,PNP,BCKDHB,FASN,ST6GALNAC3,IMPDH2,PIP5K1A,HGSNAT,SPTLC2,RDH11,RIMKLB,NME7,ATP5C1,DGAT2,MDH1,B4GAT1,ALG2,HEXA,BTD,GALE,SDSL,GATB,ATP6V1A,PAFAH1B1,ETNK1,LCLAT1,NDUFB3,PLPP1,PYCRL,DUT,XYLT2,NT5C,ACSL4,MTHFD2L,ATP6V1G1,PIGV,NDUFA9,GAPDH,POLR2L,IDH3A,SAT1,POLR2D,ATP6V0A1,MAT2A,SDHD,GRHPR,ALDH3B1,ACAT2,NME1,PEMT,ALG11,MBOAT1,PDXK,TPI1,GK,SDHC,MAN1A2,ME3,DHODH,ATP5B,RPE,PMVK,PIGF,GSS,HMGCS1,NDUFB4,PAICS,ALG13,COX7B,IMPA2,LDHB,ENOPH1,POLE2,POLE,PC,ACOX1,ALG14,PIP5KL1,GPAM,HK1,AFMID,SRM,CYP24A1,GNPDA1,UQCRB,MCCC1,SLC33A1,PHOSPHO1,LIPG,EXT1,CDIPT,PIGL,GLUL,AADAT,PAPSS1,ACAA2,POLE3,MPST,PLPP2,CCBL2,GANC,PIGO,IDH1,NAPRT,ODC1,DLST,ACOT1,GMPPA,AKR1A1,ATP5F1,GLS,ALG3,LSS,HPRT1,P4HA2,PAFAH1B2,DHFRL1,XYLB,HSD17B10,ASAH1,COX4I1,B4GALT4,DHRS3,PGAP1,TK2,B4GALNT1,ALDH4A1,C1GALT1,FPGS,PTS,ATP6V1H,ALDH18A1,SC5D,ALDH3A2,POLR3F,IMPA1,NTPCR,NSDHL,ACSL3,AMD1,SCP2,TM7SF2,HSD17B4,PGD,IDS,COX17,REV3L,POLR2E,ATP5A1,PLD1,PANK3,NADK,POLD2,CHDH,NDUFA5,MPI,UGP2,SUCLG1,UGCG,DGKD,LPIN3,NDUFA13,GGPS1,POLD1,CYP26A1,UXS1,IDI1,PANK4,AHCYL1,MMAB,GLYCTK,CTH,UROS,POLR2G,PGLS,GBA2,CPOX,ATP5E,ST3GAL3,ACO2,PTGS2,GMPPB,ST3GAL1,FAHD1,MBOAT2,GNE,APRT,PI4KA,PMM2,ADH5,IPPK,NDUFV1,COX6A1,HMGCL,PTGES3,POLR1B,PCK2,HK3,CPS1,TRIT1,ECHS1,PPOX,POLR3A,ATP6V1D,NAT1,IMPDH1,PGAM1,SAT2,ACOX3,PTGES,GCSH,DHRS4L2,PPCS,NDUFB6,PRDX6,CSAD,GCDH,OAT,PLA2G16,MTMR2,POLR3K,TYMP,ST3GAL4,AGPAT5,LIPT2,NDUFB8,SUCLG2,ME1,DPYD,NDUFA10,CSGALNACT2,GLDC,PDHA1,GSTZ1,DTYMK,EARS2,PIGK,GALNT7,PRIM1,GPAT4,KDSR,TYMS,UQCRH,B4GALT2,COX5B,EHHADH,POLR2K,ALG12,ST6GAL1,AK6,ADO,RRM1,DPM3,NDUFA4,ISYNA1,ADSSL1,NDUFS7,NDUFS4,PI4KB,MSMO1,DAD1,ATIC,PTDSS2,ATP6V0A2,PCYT2,LPCAT1,IDUA,TRAK2,ALG1,FDFT1,GFPT1,PIGC,PRODH,PRIM2,POLA1,DCTD,PKM,TWISTNB,PI4K2A,LIPT1,MTHFD2,PGP,RRM2B,DCK,GCH1,LPCAT4,PGAM2,UMPS,CNDP2,DHCR7,ACSM3,SCLY,PPT2,UROD,NDUFB5,IDH2,NDUFAB1,ATP5I,FLAD1,ASNS,MTMR4,ALDOC,DOLK,PIGB,CMPK1,TALDO1,ALG9,COX7C,PANK1,COX11,POLG2,DDOST,CERS6,DCXR,G6PD,PIGW,NDUFS1,BCKDHA,MRI1,AGPAT3,LIAS,EBP,DHRS4L1,DCTPP1,NDUFA2,MGAT1,PIGP,NME4,PHYKPL,NDUFA3,NT5M,PNPO,PCCB,B3GNT2,PSAT1,NDST2,AGPAT4,ADSL,C1GALT1C1,UQCRC1,POLR2A,SGSH,ACADSB,ATP5G3,DEGS1,ADK,B4GALT7,NMRK1,ACSL1,UQCR10,UGDH,ATP6AP1,CERS5,MOGS,DPAGT1,AHCYL2,BCAT2,GOT2,IMPAD1,NME2,HADHB,UQCRC2,HYAL1,AKR1B1,GPAA1,NDUFV3,NDUFB9,POLR3B,NDUFA6,ATP6V1E1,GALNT18,NDUFS2,ITPA,DPM1,RRM2,MTHFD1L,MAN2A2,AK1,HPSE,KYNU,NNT,GALNT10,NDUFA8,ATP6V0E1,NFS1,GPT2,PANK2,FAM213B,GPAT3,ALG8,ASL,CHSY1,CHKA,PFKL,OCRL,ENO3,CTPS2,GMPS,ACAD8,GAD1,ATP6V0D1,POLR1E,MTHFD1,ALDH9A1,ATP5G1,EPT1,POLR2I,NME6,NMNAT1,PPAT,BPGM,GBA,TBXAS1,GLCE,FDPS,MCAT,PTDSS1,GFPT2,MDH2,PIGH,EXT2,CS,GALNT4,APIP,SEPHS1,AZIN2,ALG10B,MCEE,COQ5,B3GALT4,UCKL1,UQCRQ,HKDC1,PDHX,NME3,TPK1,PON2,ALAD,TCIRG1,NDUFA1,CYP2U1,SPHK2,NDUFB7,PSPH,RPIA,CDS2,ENO2,PGM2,SPHK1,ACAA1,CCBL1,IPMK,SHMT2,DBT,PLA2G6,AMPD2,PGM1,GCLC,NADK2,POLR3GL,G6PC3,ATP5J2,POLD3,MTHFS,COX8A,ACAT1,DHFR,GLB1,ATP6V1C1,IDH3B,POLR1C,PCYT1A
hsa05010	Alzheimer's disease	6.9879926373862e-06	-11.8713172193012	162	87	0.0342115611482501	2543	6908	4698,836,4712,7381,102,29796,4711,9451,4706,3709,51079,4709,488,5664,7385,4714,4715,4731,4700,841,4705,4720,8883,4704,4717,2597,1350,51107,27089,842,4035,514,3710,515,6392,6622,3416,2081,4694,2932,5533,7388,4713,5594,4702,23385,823,4137,4729,1329,4719,6391,23621,322,3028,808,1327,4697,5532,506,83464,374291,4724,824,4723,4695,25825,4710,1337,10476,10975,1349,55967,4696,516,6868,7384,5595,840,518,509,9167,3708,1351,5534,498,317	NDUFA5,CASP3,NDUFB6,UQCRB,ADAM10,UQCR10,NDUFB5,EIF2AK3,NDUFAB1,ITPR2,NDUFA13,NDUFB3,ATP2A2,PSEN2,UQCRC2,NDUFB8,NDUFB9,NDUFV3,NDUFA6,CASP8,NDUFA10,NDUFS2,NAE1,NDUFA9,NDUFC1,GAPDH,COX7C,APH1A,UQCRQ,CASP9,LRP1,ATP5E,ITPR3,ATP5F1,SDHD,SNCA,IDE,ERN1,NDUFA1,GSK3B,PPP3CC,UQCRH,NDUFB7,MAPK1,NDUFA8,NCSTN,CAPN1,MAPT,NDUFV2,COX5B,NDUFS1,SDHC,BACE1,APBB1,HSD17B10,CALM3,COX4I1,NDUFA4,PPP3CB,ATP5B,APH1B,NDUFS7,NDUFS4,CAPN2,NDUFV1,NDUFA2,BACE2,NDUFB4,COX6A1,ATP5H,UQCR11,COX7B,NDUFA12,NDUFA3,ATP5G1,ADAM17,UQCRC1,MAPK3,CASP7,ATP5G3,ATP5C1,COX7A2L,ITPR1,COX8A,PPP3R1,ATP5A1,APAF1
ko05010	Alzheimer's disease	6.9879926373862e-06	-11.8713172193012	162	87	0.0342115611482501	2543	6908	4698,836,4712,7381,102,29796,4711,9451,4706,3709,51079,4709,488,5664,7385,4714,4715,4731,4700,841,4705,4720,8883,4704,4717,2597,1350,51107,27089,842,4035,514,3710,515,6392,6622,3416,2081,4694,2932,5533,7388,4713,5594,4702,23385,823,4137,4729,1329,4719,6391,23621,322,3028,808,1327,4697,5532,506,83464,374291,4724,824,4723,4695,25825,4710,1337,10476,10975,1349,55967,4696,516,6868,7384,5595,840,518,509,9167,3708,1351,5534,498,317	NDUFA5,CASP3,NDUFB6,UQCRB,ADAM10,UQCR10,NDUFB5,EIF2AK3,NDUFAB1,ITPR2,NDUFA13,NDUFB3,ATP2A2,PSEN2,UQCRC2,NDUFB8,NDUFB9,NDUFV3,NDUFA6,CASP8,NDUFA10,NDUFS2,NAE1,NDUFA9,NDUFC1,GAPDH,COX7C,APH1A,UQCRQ,CASP9,LRP1,ATP5E,ITPR3,ATP5F1,SDHD,SNCA,IDE,ERN1,NDUFA1,GSK3B,PPP3CC,UQCRH,NDUFB7,MAPK1,NDUFA8,NCSTN,CAPN1,MAPT,NDUFV2,COX5B,NDUFS1,SDHC,BACE1,APBB1,HSD17B10,CALM3,COX4I1,NDUFA4,PPP3CB,ATP5B,APH1B,NDUFS7,NDUFS4,CAPN2,NDUFV1,NDUFA2,BACE2,NDUFB4,COX6A1,ATP5H,UQCR11,COX7B,NDUFA12,NDUFA3,ATP5G1,ADAM17,UQCRC1,MAPK3,CASP7,ATP5G3,ATP5C1,COX7A2L,ITPR1,COX8A,PPP3R1,ATP5A1,APAF1
ko03013	RNA transport	1.22419486986701e-05	-11.3106420861446	166	88	0.0346047974832875	2543	6908	8563,23511,65109,9984,79228,1964,7919,3646,348995,55110,10556,54960,55520,9775,57122,8665,9972,5901,1983,1977,11171,81929,10460,65110,54913,29107,8669,10921,9631,5411,8021,8666,11260,8667,8661,1207,25929,5903,1981,7514,1978,1967,1979,10284,8662,8637,51068,138716,55916,6396,8480,10250,10482,8672,10775,22985,1915,129401,23165,9883,7341,10209,79833,26019,50628,10419,79902,26986,3837,23191,84305,1974,91181,5905,9513,8487,9669,1982,100101267,7175,5976,1968,57187,1965,8892,22916,23636,51808	THOC5,NUP188,UPF3B,THOC1,THOC6,EIF1AX,DDX39B,EIF3E,NUP43,MAGOHB,RPP30,GEMIN8,ELAC1,EIF4A3,NUP107,EIF3F,NUP153,RAN,EIF5,EIF4E,STRAP,SEH1L,TACC3,UPF3A,RPP25,NXT1,EIF3J,RNPS1,NUP155,PNN,NUP214,EIF3G,XPOT,EIF3H,EIF3A,CLNS1A,GEMIN5,RANBP2,EIF4G1,XPO1,EIF4EBP1,EIF2B1,EIF4EBP2,SAP18,EIF3B,EIF4EBP3,NMD3,RPP25L,NXT2,SEC13,RAE1,SRRM1,NXF1,EIF4G3,POP4,ACIN1,EEF1A1,NUP35,NUP205,POM121,SUMO1,EIF1,GEMIN6,UPF2,GEMIN4,PRMT5,NUP85,PABPC1,KPNB1,CYFIP1,PYM1,EIF4A2,NUP210L,RANGAP1,FXR2,GEMIN2,EIF5B,EIF4G2,POM121C,TPR,UPF1,EIF2S3,THOC2,EIF2S1,EIF2B2,NCBP2,NUP62,PHAX
hsa03013	RNA transport	1.22419486986701e-05	-11.3106420861446	166	88	0.0346047974832875	2543	6908	8563,23511,65109,9984,79228,1964,7919,3646,348995,55110,10556,54960,55520,9775,57122,8665,9972,5901,1983,1977,11171,81929,10460,65110,54913,29107,8669,10921,9631,5411,8021,8666,11260,8667,8661,1207,25929,5903,1981,7514,1978,1967,1979,10284,8662,8637,51068,138716,55916,6396,8480,10250,10482,8672,10775,22985,1915,129401,23165,9883,7341,10209,79833,26019,50628,10419,79902,26986,3837,23191,84305,1974,91181,5905,9513,8487,9669,1982,100101267,7175,5976,1968,57187,1965,8892,22916,23636,51808	THOC5,NUP188,UPF3B,THOC1,THOC6,EIF1AX,DDX39B,EIF3E,NUP43,MAGOHB,RPP30,GEMIN8,ELAC1,EIF4A3,NUP107,EIF3F,NUP153,RAN,EIF5,EIF4E,STRAP,SEH1L,TACC3,UPF3A,RPP25,NXT1,EIF3J,RNPS1,NUP155,PNN,NUP214,EIF3G,XPOT,EIF3H,EIF3A,CLNS1A,GEMIN5,RANBP2,EIF4G1,XPO1,EIF4EBP1,EIF2B1,EIF4EBP2,SAP18,EIF3B,EIF4EBP3,NMD3,RPP25L,NXT2,SEC13,RAE1,SRRM1,NXF1,EIF4G3,POP4,ACIN1,EEF1A1,NUP35,NUP205,POM121,SUMO1,EIF1,GEMIN6,UPF2,GEMIN4,PRMT5,NUP85,PABPC1,KPNB1,CYFIP1,PYM1,EIF4A2,NUP210L,RANGAP1,FXR2,GEMIN2,EIF5B,EIF4G2,POM121C,TPR,UPF1,EIF2S3,THOC2,EIF2S1,EIF2B2,NCBP2,NUP62,PHAX
hsa03460	Fanconi anemia pathway	4.59107255619033e-05	-9.98881179582229	53	34	0.0133700353912702	2543	6908	2176,2177,201254,22909,2072,641,80010,57599,55215,55120,84464,29089,91442,84126,7398,51455,9894,2067,3280,353497,672,2189,57697,2178,2175,2187,5889,5980,79728,5888,80198,197342,80233,5429	FANCC,FANCD2,STRA13,FAN1,ERCC4,BLM,RMI1,WDR48,FANCI,FANCL,SLX4,UBE2T,FAAP24,ATRIP,USP1,REV1,TELO2,ERCC1,HES1,POLN,BRCA1,FANCG,FANCM,FANCE,FANCA,FANCB,RAD51C,REV3L,PALB2,RAD51,MUS81,EME2,FAAP100,POLH
ko03460	Fanconi anemia pathway	4.59107255619033e-05	-9.98881179582229	53	34	0.0133700353912702	2543	6908	2176,2177,201254,22909,2072,641,80010,57599,55215,55120,84464,29089,91442,84126,7398,51455,9894,2067,3280,353497,672,2189,57697,2178,2175,2187,5889,5980,79728,5888,80198,197342,80233,5429	FANCC,FANCD2,STRA13,FAN1,ERCC4,BLM,RMI1,WDR48,FANCI,FANCL,SLX4,UBE2T,FAAP24,ATRIP,USP1,REV1,TELO2,ERCC1,HES1,POLN,BRCA1,FANCG,FANCM,FANCE,FANCA,FANCB,RAD51C,REV3L,PALB2,RAD51,MUS81,EME2,FAAP100,POLH
hsa05131	Shigellosis	7.06605035298121e-05	-9.55762378996452	64	39	0.0153362170664569	2543	6908	10163,391,5599,23291,81873,8936,71,5879,1147,10093,5217,10459,25,1399,63916,10092,3551,5601,2017,7414,5970,9475,3678,10552,199746,1729,5595,1398,10392,7307,8976,7322,3688,60,6093,4793,9474,10109,5594	WASF2,RHOG,MAPK8,FBXW11,ARPC5L,WASF1,ACTG1,RAC1,CHUK,ARPC4,PFN2,MAD2L2,ABL1,CRKL,ELMO2,ARPC5,IKBKB,MAPK9,CTTN,VCL,RELA,ROCK2,ITGA5,ARPC1A,U2AF1L4,DIAPH1,MAPK3,CRK,NOD1,U2AF1,WASL,UBE2D2,ITGB1,ACTB,ROCK1,NFKBIB,ATG5,ARPC2,MAPK1
hsa04115	p53 signaling pathway	0.000172317240676028	-8.6661733574744	68	40	0.0157294534014943	2543	6908	836,55367,7249,3732,8493,10912,4194,1111,1026,891,898,7057,4193,143686,6477,5366,896,581,841,1021,3486,901,1643,842,6241,51246,900,27244,9540,983,64326,1647,50484,4616,5268,317,9133,64393,1029,2810	CASP3,PIDD1,TSC2,CD82,PPM1D,GADD45G,MDM4,CHEK1,CDKN1A,CCNB1,CCNE1,THBS1,MDM2,SESN3,SIAH1,PMAIP1,CCND3,BAX,CASP8,CDK6,IGFBP3,CCNG2,DDB2,CASP9,RRM2,SHISA5,CCNG1,SESN1,TP53I3,CDK1,RFWD2,GADD45A,RRM2B,GADD45B,SERPINB5,APAF1,CCNB2,ZMAT3,CDKN2A,SFN
ko04115	p53 signaling pathway	0.000172317240676028	-8.6661733574744	68	40	0.0157294534014943	2543	6908	836,55367,7249,3732,8493,10912,4194,1111,1026,891,898,7057,4193,143686,6477,5366,896,581,841,1021,3486,901,1643,842,6241,51246,900,27244,9540,983,64326,1647,50484,4616,5268,317,9133,64393,1029,2810	CASP3,PIDD1,TSC2,CD82,PPM1D,GADD45G,MDM4,CHEK1,CDKN1A,CCNB1,CCNE1,THBS1,MDM2,SESN3,SIAH1,PMAIP1,CCND3,BAX,CASP8,CDK6,IGFBP3,CCNG2,DDB2,CASP9,RRM2,SHISA5,CCNG1,SESN1,TP53I3,CDK1,RFWD2,GADD45A,RRM2B,GADD45B,SERPINB5,APAF1,CCNB2,ZMAT3,CDKN2A,SFN
ko05169	Epstein-Barr virus infection	0.000184952509299799	-8.59541147232827	199	98	0.038537160833661	2543	6908	5599,2033,9451,1147,3661,1026,7531,5566,4067,51728,3303,5606,1387,4193,890,5610,3551,5296,5701,10213,1027,8503,55703,5901,4791,1386,3588,5970,5567,5441,5436,207,208,5433,10971,958,8021,7297,983,10014,7532,5432,3305,5335,7514,7185,5719,9759,23118,5706,5709,5757,3065,2932,5705,9861,10454,5700,3066,5440,6908,171568,7186,5713,440275,3105,22938,5708,5601,5717,9020,2959,6774,10621,29110,5438,5609,7128,5295,5702,6502,84265,5710,5430,11128,3587,3304,5704,5608,7979,5434,9519,7534,3516,9533,4793,7533,6416	MAPK8,EP300,EIF2AK3,CHUK,IRF3,CDKN1A,YWHAE,PRKACA,LYN,POLR3K,HSPA1A,MAP2K3,CREBBP,MDM2,CCNA2,EIF2AK2,IKBKB,PIK3R2,PSMC2,PSMD14,CDKN1B,PIK3R3,POLR3B,RAN,NFKB2,ATF2,IL10RB,RELA,PRKACB,POLR2L,POLR2G,AKT1,AKT2,POLR2D,YWHAQ,CD40,NUP214,TYK2,CDK1,HDAC5,YWHAG,POLR2C,HSPA1L,PLCG1,XPO1,TRAF1,PSMD13,HDAC4,TAB2,PSMC6,PSMD3,PTMA,HDAC1,GSK3B,PSMC5,PSMD6,TAB1,PSMC1,HDAC2,POLR2K,TBP,POLR3H,TRAF2,PSMD7,EIF2AK4,HLA-A,SNW1,PSMD2,MAPK9,PSMD11,MAP3K14,GTF2B,STAT3,POLR3F,TBK1,POLR2I,MAP2K7,TNFAIP3,PIK3R1,PSMC3,SKP2,POLR3GL,PSMD4,POLR2A,POLR3A,IL10RA,HSPA1B,PSMC4,MAP2K6,SHFM1,POLR2E,TBPL1,YWHAZ,RBPJ,POLR1C,NFKBIB,YWHAH,MAP2K4
hsa05169	Epstein-Barr virus infection	0.000184952509299799	-8.59541147232827	199	98	0.038537160833661	2543	6908	5599,2033,9451,1147,3661,1026,7531,5566,4067,51728,3303,5606,1387,4193,890,5610,3551,5296,5701,10213,1027,8503,55703,5901,4791,1386,3588,5970,5567,5441,5436,207,208,5433,10971,958,8021,7297,983,10014,7532,5432,3305,5335,7514,7185,5719,9759,23118,5706,5709,5757,3065,2932,5705,9861,10454,5700,3066,5440,6908,171568,7186,5713,440275,3105,22938,5708,5601,5717,9020,2959,6774,10621,29110,5438,5609,7128,5295,5702,6502,84265,5710,5430,11128,3587,3304,5704,5608,7979,5434,9519,7534,3516,9533,4793,7533,6416	MAPK8,EP300,EIF2AK3,CHUK,IRF3,CDKN1A,YWHAE,PRKACA,LYN,POLR3K,HSPA1A,MAP2K3,CREBBP,MDM2,CCNA2,EIF2AK2,IKBKB,PIK3R2,PSMC2,PSMD14,CDKN1B,PIK3R3,POLR3B,RAN,NFKB2,ATF2,IL10RB,RELA,PRKACB,POLR2L,POLR2G,AKT1,AKT2,POLR2D,YWHAQ,CD40,NUP214,TYK2,CDK1,HDAC5,YWHAG,POLR2C,HSPA1L,PLCG1,XPO1,TRAF1,PSMD13,HDAC4,TAB2,PSMC6,PSMD3,PTMA,HDAC1,GSK3B,PSMC5,PSMD6,TAB1,PSMC1,HDAC2,POLR2K,TBP,POLR3H,TRAF2,PSMD7,EIF2AK4,HLA-A,SNW1,PSMD2,MAPK9,PSMD11,MAP3K14,GTF2B,STAT3,POLR3F,TBK1,POLR2I,MAP2K7,TNFAIP3,PIK3R1,PSMC3,SKP2,POLR3GL,PSMD4,POLR2A,POLR3A,IL10RA,HSPA1B,PSMC4,MAP2K6,SHFM1,POLR2E,TBPL1,YWHAZ,RBPJ,POLR1C,NFKBIB,YWHAH,MAP2K4
hsa04114	Oocyte meiosis	0.000198400799324778	-8.52522133426689	112	60	0.0235941801022414	2543	6908	23291,51433,80315,9748,9232,5604,808,8454,5532,3709,7531,891,5566,5501,898,10459,5519,26271,64682,6196,9126,51529,115,10393,699,51434,5499,5567,9978,991,10971,29882,9088,8697,3710,995,983,7532,5595,5529,817,286151,996,3708,4085,5534,8243,6790,5527,5500,7534,5533,5594,151648,9133,7533,5528,132864,9700,6197	FBXW11,ANAPC5,CPEB4,SLK,PTTG1,MAP2K1,CALM3,CUL1,PPP3CB,ITPR2,YWHAE,CCNB1,PRKACA,PPP1CC,CCNE1,MAD2L2,PPP2R1B,FBXO5,ANAPC1,RPS6KA2,SMC3,ANAPC11,ADCY9,ANAPC10,BUB1,ANAPC7,PPP1CA,PRKACB,RBX1,CDC20,YWHAQ,ANAPC2,PKMYT1,CDC23,ITPR3,CDC25C,CDK1,YWHAG,MAPK3,PPP2R5E,CAMK2D,FBXO43,CDC27,ITPR1,MAD2L1,PPP3R1,SMC1A,AURKA,PPP2R5C,PPP1CB,YWHAZ,PPP3CC,MAPK1,SGOL1,CCNB2,YWHAH,PPP2R5D,CPEB2,ESPL1,RPS6KA3
ko04114	Oocyte meiosis	0.000198400799324778	-8.52522133426689	112	60	0.0235941801022414	2543	6908	23291,51433,80315,9748,9232,5604,808,8454,5532,3709,7531,891,5566,5501,898,10459,5519,26271,64682,6196,9126,51529,115,10393,699,51434,5499,5567,9978,991,10971,29882,9088,8697,3710,995,983,7532,5595,5529,817,286151,996,3708,4085,5534,8243,6790,5527,5500,7534,5533,5594,151648,9133,7533,5528,132864,9700,6197	FBXW11,ANAPC5,CPEB4,SLK,PTTG1,MAP2K1,CALM3,CUL1,PPP3CB,ITPR2,YWHAE,CCNB1,PRKACA,PPP1CC,CCNE1,MAD2L2,PPP2R1B,FBXO5,ANAPC1,RPS6KA2,SMC3,ANAPC11,ADCY9,ANAPC10,BUB1,ANAPC7,PPP1CA,PRKACB,RBX1,CDC20,YWHAQ,ANAPC2,PKMYT1,CDC23,ITPR3,CDC25C,CDK1,YWHAG,MAPK3,PPP2R5E,CAMK2D,FBXO43,CDC27,ITPR1,MAD2L1,PPP3R1,SMC1A,AURKA,PPP2R5C,PPP1CB,YWHAZ,PPP3CC,MAPK1,SGOL1,CCNB2,YWHAH,PPP2R5D,CPEB2,ESPL1,RPS6KA3
ko00230	Purine metabolism	0.000218335635215785	-8.42947706807965	174	87	0.0342115611482501	2543	6908	955,122481,51251,5424,51728,5139,5147,9583,115,9061,4831,30833,2272,5144,55703,54107,30834,5436,5441,3704,5433,6241,27115,4832,5557,5432,203,3251,4830,124583,53343,55276,5440,171568,102157402,6240,353,122622,957,471,10606,4833,8833,11164,50808,84172,56953,64425,10621,271,5236,374659,84284,5438,5141,5558,10201,4860,954,5471,5422,158,84265,8654,4881,3615,5315,318,10714,58497,5430,11128,221830,50940,131870,51292,5426,5427,29922,50484,1633,5150,5434,3614,9533,132,5425	ENTPD6,AK7,NT5C3A,POLD1,POLR3K,PDE3A,PDE6D,ENTPD4,ADCY9,PAPSS1,NME2,NT5C,FHIT,PDE4D,POLR3B,POLE3,ZNRD1,POLR2G,POLR2L,ITPA,POLR2D,RRM2,PDE7B,NME3,PRIM1,POLR2C,AK1,HPRT1,NME1,CANT1,NUDT9,PGM2,POLR2K,POLR3H,AK6,RRM1,APRT,ADSSL1,ENTPD5,ATIC,PAICS,NME4,GMPS,NUDT5,AK3,POLR1B,NT5M,POLR1E,POLR3F,AMPD2,PGM1,HDDC3,NTPCR,POLR2I,PDE4A,PRIM2,NME6,PNP,ENTPD2,PPAT,POLA1,ADSL,POLR3GL,PDE5A,NPR1,IMPDH2,PKM,NUDT2,POLD3,PRUNE,POLR2A,POLR3A,TWISTNB,PDE11A,NUDT16,GMPR2,POLE,POLE2,NME7,RRM2B,DCK,PDE7A,POLR2E,IMPDH1,POLR1C,ADK,POLD2
hsa00230	Purine metabolism	0.000218335635215785	-8.42947706807965	174	87	0.0342115611482501	2543	6908	955,122481,51251,5424,51728,5139,9583,5147,9061,115,4831,30833,2272,54107,55703,5144,30834,5436,5441,3704,5433,6241,27115,4832,5557,5432,203,3251,4830,124583,53343,55276,5440,171568,102157402,6240,353,122622,957,471,10606,4833,8833,11164,84172,50808,56953,64425,10621,271,5236,374659,84284,5438,954,4860,5558,10201,5141,5471,5422,84265,8654,4881,158,3615,5315,318,10714,58497,11128,221830,5430,50940,131870,51292,29922,5427,5426,50484,1633,5434,5150,3614,9533,132,5425	ENTPD6,AK7,NT5C3A,POLD1,POLR3K,PDE3A,ENTPD4,PDE6D,PAPSS1,ADCY9,NME2,NT5C,FHIT,POLE3,POLR3B,PDE4D,ZNRD1,POLR2G,POLR2L,ITPA,POLR2D,RRM2,PDE7B,NME3,PRIM1,POLR2C,AK1,HPRT1,NME1,CANT1,NUDT9,PGM2,POLR2K,POLR3H,AK6,RRM1,APRT,ADSSL1,ENTPD5,ATIC,PAICS,NME4,GMPS,NUDT5,POLR1B,AK3,NT5M,POLR1E,POLR3F,AMPD2,PGM1,HDDC3,NTPCR,POLR2I,ENTPD2,PNP,PRIM2,NME6,PDE4A,PPAT,POLA1,POLR3GL,PDE5A,NPR1,ADSL,IMPDH2,PKM,NUDT2,POLD3,PRUNE,POLR3A,TWISTNB,POLR2A,PDE11A,NUDT16,GMPR2,NME7,POLE2,POLE,RRM2B,DCK,POLR2E,PDE7A,IMPDH1,POLR1C,ADK,POLD2
hsa05203	Viral carcinogenesis	0.000249599956503439	-8.29565109573408	205	100	0.0393236335037357	2543	6908	2033,836,5879,6777,3661,1960,1026,7531,10013,5566,4067,898,440689,8365,1387,4193,890,5610,6672,5366,8366,8364,3572,5296,1739,8379,1027,8503,7419,1108,4791,841,1386,5970,1021,5567,578,468,991,10971,87,983,23352,10014,7532,1654,8294,2934,7185,9759,9093,81,6722,3065,5594,5700,3066,1030,1388,8367,6908,5966,7186,1111,83933,10488,8360,3105,121504,22938,7337,51564,896,5902,581,8345,2959,6774,9114,387,2648,8841,5295,6502,23513,5315,8368,55697,5595,2885,2957,9519,3190,6776,7534,3516,7533,3265,1029,1642	EP300,CASP3,RAC1,STAT5B,IRF3,EGR3,CDKN1A,YWHAE,HDAC6,PRKACA,LYN,CCNE1,HIST2H2BF,HIST1H4H,CREBBP,MDM2,CCNA2,EIF2AK2,SP100,PMAIP1,HIST1H4B,HIST1H4C,IL6ST,PIK3R2,DLG1,MAD1L1,CDKN1B,PIK3R3,VDAC3,CHD4,NFKB2,CASP8,ATF2,RELA,CDK6,PRKACB,BAK1,ATF4,CDC20,YWHAQ,ACTN1,CDK1,UBR4,HDAC5,YWHAG,DDX3X,HIST1H4I,GSN,TRAF1,HDAC4,DNAJA3,ACTN4,SRF,HDAC1,MAPK1,PSMC1,HDAC2,CDKN2B,ATF6B,HIST1H4E,TBP,REL,TRAF2,CHEK1,HDAC10,CREB3,HIST1H4D,HLA-A,HIST4H4,SNW1,UBE3A,HDAC7,CCND3,RANBP1,BAX,HIST1H2BH,GTF2B,STAT3,ATP6V0D1,RHOA,KAT2A,HDAC3,PIK3R1,SKP2,SCRIB,PKM,HIST1H4L,VAC14,MAPK3,GRB2,GTF2A1,TBPL1,HNRNPK,STAT5A,YWHAZ,RBPJ,YWHAH,HRAS,CDKN2A,DDB1
ko05203	Viral carcinogenesis	0.000249599956503439	-8.29565109573408	205	100	0.0393236335037357	2543	6908	2033,836,5879,6777,3661,1960,1026,7531,10013,5566,4067,898,440689,8365,1387,4193,890,5610,6672,5366,8366,8364,3572,5296,1739,8379,1027,8503,7419,1108,4791,841,1386,5970,1021,5567,578,468,991,10971,87,983,23352,10014,7532,1654,8294,2934,7185,9759,9093,81,6722,3065,5594,5700,3066,1030,1388,8367,6908,5966,7186,1111,83933,10488,8360,3105,121504,22938,7337,51564,896,5902,581,8345,2959,6774,9114,387,2648,8841,5295,6502,23513,5315,8368,55697,5595,2885,2957,9519,3190,6776,7534,3516,7533,3265,1029,1642	EP300,CASP3,RAC1,STAT5B,IRF3,EGR3,CDKN1A,YWHAE,HDAC6,PRKACA,LYN,CCNE1,HIST2H2BF,HIST1H4H,CREBBP,MDM2,CCNA2,EIF2AK2,SP100,PMAIP1,HIST1H4B,HIST1H4C,IL6ST,PIK3R2,DLG1,MAD1L1,CDKN1B,PIK3R3,VDAC3,CHD4,NFKB2,CASP8,ATF2,RELA,CDK6,PRKACB,BAK1,ATF4,CDC20,YWHAQ,ACTN1,CDK1,UBR4,HDAC5,YWHAG,DDX3X,HIST1H4I,GSN,TRAF1,HDAC4,DNAJA3,ACTN4,SRF,HDAC1,MAPK1,PSMC1,HDAC2,CDKN2B,ATF6B,HIST1H4E,TBP,REL,TRAF2,CHEK1,HDAC10,CREB3,HIST1H4D,HLA-A,HIST4H4,SNW1,UBE3A,HDAC7,CCND3,RANBP1,BAX,HIST1H2BH,GTF2B,STAT3,ATP6V0D1,RHOA,KAT2A,HDAC3,PIK3R1,SKP2,SCRIB,PKM,HIST1H4L,VAC14,MAPK3,GRB2,GTF2A1,TBPL1,HNRNPK,STAT5A,YWHAZ,RBPJ,YWHAH,HRAS,CDKN2A,DDB1
hsa03008	Ribosome biogenesis in eukaryotes	0.000311014864734707	-8.07566985035264	78	44	0.0173023987416437	2543	6908	84128,27341,10813,28987,102157402,10436,55226,10482,10885,10775,79631,51119,10556,3692,55813,51096,22803,5901,2091,23160,84916,92856,54913,29107,26354,23560,65083,5822,166378,1736,54433,51602,55341,7514,10607,57455,54552,55127,23195,54464,51068,138716,55916,55505	WDR75,RRP7A,UTP14A,NOB1,AK6,EMG1,NAT10,NXF1,WDR3,POP4,EFTUD1,SBDS,RPP30,EIF6,UTP6,UTP18,XRN2,RAN,FBL,WDR43,UTP4,IMP4,RPP25,NXT1,GNL3,GTPBP4,NOL6,PWP2,SPATA5,DKC1,GAR1,NOP58,LSG1,XPO1,TBL3,REXO1,GNL3L,HEATR1,MDN1,XRN1,NMD3,RPP25L,NXT2,NOP10
ko03008	Ribosome biogenesis in eukaryotes	0.000311014864734707	-8.07566985035264	78	44	0.0173023987416437	2543	6908	84128,27341,10813,28987,102157402,10436,55226,10482,10885,10775,79631,51119,10556,3692,55813,51096,22803,5901,2091,23160,84916,92856,54913,29107,26354,23560,65083,5822,166378,1736,54433,51602,55341,7514,10607,57455,54552,55127,23195,54464,51068,138716,55916,55505	WDR75,RRP7A,UTP14A,NOB1,AK6,EMG1,NAT10,NXF1,WDR3,POP4,EFTUD1,SBDS,RPP30,EIF6,UTP6,UTP18,XRN2,RAN,FBL,WDR43,UTP4,IMP4,RPP25,NXT1,GNL3,GTPBP4,NOL6,PWP2,SPATA5,DKC1,GAR1,NOP58,LSG1,XPO1,TBL3,REXO1,GNL3L,HEATR1,MDN1,XRN1,NMD3,RPP25L,NXT2,NOP10
hsa04910	Insulin signaling pathway	0.000366025658374279	-7.91280712217238	139	71	0.0279197797876524	2543	6908	5599,10580,6517,7249,2475,5837,5894,5565,8835,5604,5507,5566,1399,57521,8651,6464,5255,3551,5296,6194,8503,5499,89801,5256,1977,5567,31,6655,207,208,5571,80201,6009,9021,8660,1398,1978,5590,2932,5500,6198,10891,5594,3636,673,5562,808,23265,5501,79660,5601,5584,2872,5106,3101,5261,6199,5170,23433,6654,5295,2194,92579,5605,5595,2885,5792,51422,3643,3098,3265	MAPK8,SORBS1,SLC2A4,TSC2,MTOR,PYGM,RAF1,PRKAB2,SOCS2,MAP2K1,PPP1R3C,PRKACA,CRKL,RPTOR,SOCS1,SHC1,PHKA1,IKBKB,PIK3R2,RPS6,PIK3R3,PPP1CA,PPP1R3F,PHKA2,EIF4E,PRKACB,ACACA,SOS2,AKT1,AKT2,PRKAG1,HKDC1,RHEB,SOCS3,IRS2,CRK,EIF4EBP1,PRKCZ,GSK3B,PPP1CB,RPS6KB1,PPARGC1A,MAPK1,INPPL1,BRAF,PRKAA1,CALM3,EXOC7,PPP1CC,PPP1R3B,MAPK9,PRKCI,MKNK2,PCK2,HK3,PHKG2,RPS6KB2,PDPK1,RHOQ,SOS1,PIK3R1,FASN,G6PC3,MAP2K2,MAPK3,GRB2,PTPRF,PRKAG2,INSR,HK1,HRAS
ko04910	Insulin signaling pathway	0.000366025658374279	-7.91280712217238	139	71	0.0279197797876524	2543	6908	5599,10580,6517,7249,2475,5837,5894,5565,8835,5604,5507,5566,1399,57521,8651,6464,5255,3551,5296,6194,8503,5499,89801,5256,1977,5567,31,6655,207,208,5571,80201,6009,9021,8660,1398,1978,5590,2932,5500,6198,10891,5594,3636,673,5562,808,23265,5501,79660,5601,5584,2872,5106,3101,5261,6199,5170,23433,6654,5295,2194,92579,5605,5595,2885,5792,51422,3643,3098,3265	MAPK8,SORBS1,SLC2A4,TSC2,MTOR,PYGM,RAF1,PRKAB2,SOCS2,MAP2K1,PPP1R3C,PRKACA,CRKL,RPTOR,SOCS1,SHC1,PHKA1,IKBKB,PIK3R2,RPS6,PIK3R3,PPP1CA,PPP1R3F,PHKA2,EIF4E,PRKACB,ACACA,SOS2,AKT1,AKT2,PRKAG1,HKDC1,RHEB,SOCS3,IRS2,CRK,EIF4EBP1,PRKCZ,GSK3B,PPP1CB,RPS6KB1,PPARGC1A,MAPK1,INPPL1,BRAF,PRKAA1,CALM3,EXOC7,PPP1CC,PPP1R3B,MAPK9,PRKCI,MKNK2,PCK2,HK3,PHKG2,RPS6KB2,PDPK1,RHOQ,SOS1,PIK3R1,FASN,G6PC3,MAP2K2,MAPK3,GRB2,PTPRF,PRKAG2,INSR,HK1,HRAS
hsa04146	Peroxisome	0.000395404277093841	-7.83560183015465	83	46	0.0180888714117184	2543	6908	2180,1962,5190,26063,54677,6648,3418,5193,92960,30,10654,5192,390916,728635,5191,373156,8504,1384,9409,10455,215,3155,2182,5195,84188,10478,5824,11001,2181,6342,55825,3295,3417,84769,5264,5189,8799,847,55670,51,5828,8443,4358,5194,8310,10005	ACSL1,EHHADH,PEX6,DECR2,CROT,SOD2,IDH2,PEX12,PEX11G,ACAA1,PMVK,PEX10,NUDT19,DHRS4L1,PEX7,GSTK1,PEX3,CRAT,PEX16,ECI2,ABCD1,HMGCL,ACSL4,PEX14,FAR1,SLC25A17,PEX19,SLC27A2,ACSL3,SCP2,PECR,HSD17B4,IDH1,MPV17L2,PHYH,PEX1,PEX11B,CAT,PEX26,ACOX1,PEX2,GNPAT,MPV17,PEX13,ACOX3,ACOT8
ko04146	Peroxisome	0.000395404277093841	-7.83560183015465	83	46	0.0180888714117184	2543	6908	2180,1962,5190,26063,54677,6648,3418,5193,92960,30,10654,5192,390916,728635,5191,373156,8504,1384,9409,10455,215,3155,2182,5195,84188,10478,5824,11001,2181,6342,55825,3295,3417,84769,5264,5189,8799,847,55670,51,5828,8443,4358,5194,8310,10005	ACSL1,EHHADH,PEX6,DECR2,CROT,SOD2,IDH2,PEX12,PEX11G,ACAA1,PMVK,PEX10,NUDT19,DHRS4L1,PEX7,GSTK1,PEX3,CRAT,PEX16,ECI2,ABCD1,HMGCL,ACSL4,PEX14,FAR1,SLC25A17,PEX19,SLC27A2,ACSL3,SCP2,PECR,HSD17B4,IDH1,MPV17L2,PHYH,PEX1,PEX11B,CAT,PEX26,ACOX1,PEX2,GNPAT,MPV17,PEX13,ACOX3,ACOT8
ko05211	Renal cell carcinoma	0.000453873467253825	-7.69769210525817	66	38	0.0149429807314196	2543	6908	2033,673,2034,5894,5879,5604,2113,10298,1387,1399,5906,201163,5062,5296,5781,8503,112399,6655,207,6923,6654,9978,7039,208,5295,5908,6921,7422,5605,5595,2885,112398,1398,3091,8453,5594,3265,2549	EP300,BRAF,EPAS1,RAF1,RAC1,MAP2K1,ETS1,PAK4,CREBBP,CRKL,RAP1A,FLCN,PAK2,PIK3R2,PTPN11,PIK3R3,EGLN3,SOS2,AKT1,TCEB2,SOS1,RBX1,TGFA,AKT2,PIK3R1,RAP1B,TCEB1,VEGFA,MAP2K2,MAPK3,GRB2,EGLN2,CRK,HIF1A,CUL2,MAPK1,HRAS,GAB1
hsa05211	Renal cell carcinoma	0.000453873467253825	-7.69769210525817	66	38	0.0149429807314196	2543	6908	2033,673,2034,5894,5879,5604,2113,10298,1387,1399,5906,201163,5062,5296,5781,8503,112399,6655,207,6923,6654,9978,7039,208,5295,5908,6921,7422,5605,5595,2885,112398,1398,3091,8453,5594,3265,2549	EP300,BRAF,EPAS1,RAF1,RAC1,MAP2K1,ETS1,PAK4,CREBBP,CRKL,RAP1A,FLCN,PAK2,PIK3R2,PTPN11,PIK3R3,EGLN3,SOS2,AKT1,TCEB2,SOS1,RBX1,TGFA,AKT2,PIK3R1,RAP1B,TCEB1,VEGFA,MAP2K2,MAPK3,GRB2,EGLN2,CRK,HIF1A,CUL2,MAPK1,HRAS,GAB1
ko03410	Base excision repair	0.000464994108742608	-7.67348582182791	33	22	0.00865119937082186	2543	6908	23583,3146,328,143,3978,3980,4350,10714,5424,252969,5111,79661,10039,6996,5426,5427,55247,7374,27343,54107,4595,5425	SMUG1,HMGB1,APEX1,PARP4,LIG1,LIG3,MPG,POLD3,POLD1,NEIL2,PCNA,NEIL1,PARP3,TDG,POLE,POLE2,NEIL3,UNG,POLL,POLE3,MUTYH,POLD2
hsa03410	Base excision repair	0.000464994108742608	-7.67348582182791	33	22	0.00865119937082186	2543	6908	23583,3146,328,143,3978,3980,4350,10714,5424,252969,6996,5111,79661,10039,5427,5426,55247,27343,7374,54107,4595,5425	SMUG1,HMGB1,APEX1,PARP4,LIG1,LIG3,MPG,POLD3,POLD1,NEIL2,TDG,PCNA,NEIL1,PARP3,POLE2,POLE,NEIL3,POLL,UNG,POLE3,MUTYH,POLD2
ko04520	Adherens junction	0.000557942989156278	-7.4912537707735	73	41	0.0161226897365317	2543	6908	10163,2033,10580,8936,71,1495,8826,5879,2064,51701,7082,5881,117178,1387,1499,25945,7414,6591,2241,387,5797,6615,5777,87,7525,2260,10458,6934,5595,4088,5792,2534,4087,3643,8976,52,81,1500,60,5594,4089	WASF2,EP300,SORBS1,WASF1,ACTG1,CTNNA1,IQGAP1,RAC1,ERBB2,NLK,TJP1,RAC3,SSX2IP,CREBBP,CTNNB1,PVRL3,VCL,SNAI2,FER,RHOA,PTPRM,SNAI1,PTPN6,ACTN1,YES1,FGFR1,BAIAP2,TCF7L2,MAPK3,SMAD3,PTPRF,FYN,SMAD2,INSR,WASL,ACP1,ACTN4,CTNND1,ACTB,MAPK1,SMAD4
hsa04520	Adherens junction	0.000557942989156278	-7.4912537707735	73	41	0.0161226897365317	2543	6908	10163,2033,10580,8936,71,1495,8826,5879,2064,51701,7082,5881,117178,1387,1499,25945,7414,6591,2241,387,5797,6615,5777,87,7525,2260,10458,6934,5595,4088,5792,2534,4087,3643,8976,52,81,1500,60,5594,4089	WASF2,EP300,SORBS1,WASF1,ACTG1,CTNNA1,IQGAP1,RAC1,ERBB2,NLK,TJP1,RAC3,SSX2IP,CREBBP,CTNNB1,PVRL3,VCL,SNAI2,FER,RHOA,PTPRM,SNAI1,PTPN6,ACTN1,YES1,FGFR1,BAIAP2,TCF7L2,MAPK3,SMAD3,PTPRF,FYN,SMAD2,INSR,WASL,ACP1,ACTN4,CTNND1,ACTB,MAPK1,SMAD4
hsa05220	Chronic myeloid leukemia	0.000557942989156278	-7.4912537707735	73	41	0.0161226897365317	2543	6908	673,5894,5604,1147,6777,1488,1026,598,2122,25,1399,4193,6464,3551,5296,5781,8503,1027,5970,1021,6655,207,6654,208,5295,1871,5605,5595,2885,4088,1398,3065,6776,861,5594,1870,3265,4089,1487,1029,3066	BRAF,RAF1,MAP2K1,CHUK,STAT5B,CTBP2,CDKN1A,BCL2L1,MECOM,ABL1,CRKL,MDM2,SHC1,IKBKB,PIK3R2,PTPN11,PIK3R3,CDKN1B,RELA,CDK6,SOS2,AKT1,SOS1,AKT2,PIK3R1,E2F3,MAP2K2,MAPK3,GRB2,SMAD3,CRK,HDAC1,STAT5A,RUNX1,MAPK1,E2F2,HRAS,SMAD4,CTBP1,CDKN2A,HDAC2
ko05220	Chronic myeloid leukemia	0.000557942989156278	-7.4912537707735	73	41	0.0161226897365317	2543	6908	673,5894,5604,1147,6777,1488,1026,598,2122,25,1399,4193,6464,3551,5296,5781,8503,1027,5970,1021,6655,207,6654,208,5295,1871,5605,5595,2885,4088,1398,3065,6776,861,5594,1870,3265,4089,1487,1029,3066	BRAF,RAF1,MAP2K1,CHUK,STAT5B,CTBP2,CDKN1A,BCL2L1,MECOM,ABL1,CRKL,MDM2,SHC1,IKBKB,PIK3R2,PTPN11,PIK3R3,CDKN1B,RELA,CDK6,SOS2,AKT1,SOS1,AKT2,PIK3R1,E2F3,MAP2K2,MAPK3,GRB2,SMAD3,CRK,HDAC1,STAT5A,RUNX1,MAPK1,E2F2,HRAS,SMAD4,CTBP1,CDKN2A,HDAC2
hsa05223	Non-small cell lung cancer	0.000600932491462789	-7.41702795675521	56	33	0.0129767990562328	2543	6908	673,5894,6256,5604,11186,2064,2309,5296,8503,2272,1021,5915,5170,6655,207,6654,7039,208,842,5295,1871,83593,5605,27436,6257,5595,2885,5335,1870,5594,3265,1029,6789	BRAF,RAF1,RXRA,MAP2K1,RASSF1,ERBB2,FOXO3,PIK3R2,PIK3R3,FHIT,CDK6,RARB,PDPK1,SOS2,AKT1,SOS1,TGFA,AKT2,CASP9,PIK3R1,E2F3,RASSF5,MAP2K2,EML4,RXRB,MAPK3,GRB2,PLCG1,E2F2,MAPK1,HRAS,CDKN2A,STK4
ko05223	Non-small cell lung cancer	0.000600932491462789	-7.41702795675521	56	33	0.0129767990562328	2543	6908	673,5894,6256,5604,11186,2064,2309,5296,8503,2272,1021,5915,5170,6655,207,6654,7039,208,842,5295,1871,83593,5605,27436,6257,5595,2885,5335,1870,5594,3265,1029,6789	BRAF,RAF1,RXRA,MAP2K1,RASSF1,ERBB2,FOXO3,PIK3R2,PIK3R3,FHIT,CDK6,RARB,PDPK1,SOS2,AKT1,SOS1,TGFA,AKT2,CASP9,PIK3R1,E2F3,RASSF5,MAP2K2,EML4,RXRB,MAPK3,GRB2,PLCG1,E2F2,MAPK1,HRAS,CDKN2A,STK4
hsa05166	HTLV-I infection	0.000719586245816914	-7.23683416972132	258	120	0.0471883602044829	2543	6908	5599,2033,3601,9232,10524,1147,324,6777,22808,598,1026,821,2535,5424,5566,7474,1390,1387,1031,64682,5111,1499,3551,5296,51529,115,1739,10393,8503,7419,51434,5901,54107,4791,4603,1386,5970,5567,1856,8321,4215,468,207,8322,115650,208,991,7417,1871,467,7481,1857,8697,958,7416,8324,4088,4488,7514,4087,291,8326,4085,6722,2932,5533,8829,1870,4089,23373,1030,51433,1958,6908,94241,8325,6929,64784,1111,5532,2113,3105,811,466,896,706,5902,581,9020,22800,4801,4214,4487,6237,2648,7480,7976,5295,4605,29882,10714,55697,996,5426,5427,2114,2874,3569,7494,2224,5534,9519,6776,4776,7855,9133,6416,3265,5425,1029	MAPK8,EP300,IL15RA,PTTG1,KAT5,CHUK,APC,STAT5B,MRAS,BCL2L1,CDKN1A,CANX,FZD2,POLD1,PRKACA,WNT5A,CREM,CREBBP,CDKN2C,ANAPC1,PCNA,CTNNB1,IKBKB,PIK3R2,ANAPC11,ADCY9,DLG1,ANAPC10,PIK3R3,VDAC3,ANAPC7,RAN,POLE3,NFKB2,MYBL1,ATF2,RELA,PRKACB,DVL2,FZD1,MAP3K3,ATF4,AKT1,FZD4,TNFRSF13C,AKT2,CDC20,VDAC2,E2F3,ATF3,WNT11,DVL3,CDC23,CD40,VDAC1,FZD7,SMAD3,MSX2,XPO1,SMAD2,SLC25A4,FZD9,MAD2L1,SRF,GSK3B,PPP3CC,NRP1,E2F2,SMAD4,CRTC1,CDKN2B,ANAPC5,EGR1,TBP,TP53INP1,FZD8,TCF3,CRTC3,CHEK1,PPP3CB,ETS1,HLA-A,CALR,ATF1,CCND3,TSPO,RANBP1,BAX,MAP3K14,RRAS2,NFYB,MAP3K1,MSX1,RRAS,KAT2A,WNT10B,FZD3,PIK3R1,MYBL2,ANAPC2,POLD3,VAC14,CDC27,POLE,POLE2,ETS2,GPS2,IL6,XBP1,FDPS,PPP3R1,TBPL1,STAT5A,NFATC4,FZD5,CCNB2,MAP2K4,HRAS,POLD2,CDKN2A
ko05166	HTLV-I infection	0.000719586245816914	-7.23683416972132	258	120	0.0471883602044829	2543	6908	5599,2033,3601,9232,10524,1147,324,6777,22808,598,1026,821,2535,5424,5566,7474,1390,1387,1031,64682,5111,1499,3551,5296,51529,115,1739,10393,8503,7419,51434,5901,54107,4791,4603,1386,5970,5567,1856,8321,4215,468,207,8322,115650,208,991,7417,1871,467,7481,1857,8697,958,7416,8324,4088,4488,7514,4087,291,8326,4085,6722,2932,5533,8829,1870,4089,23373,1030,51433,1958,6908,94241,8325,6929,64784,1111,5532,2113,3105,811,466,896,706,5902,581,9020,22800,4801,4214,4487,6237,2648,7480,7976,5295,4605,29882,10714,55697,996,5426,5427,2114,2874,3569,7494,2224,5534,9519,6776,4776,7855,9133,6416,3265,5425,1029	MAPK8,EP300,IL15RA,PTTG1,KAT5,CHUK,APC,STAT5B,MRAS,BCL2L1,CDKN1A,CANX,FZD2,POLD1,PRKACA,WNT5A,CREM,CREBBP,CDKN2C,ANAPC1,PCNA,CTNNB1,IKBKB,PIK3R2,ANAPC11,ADCY9,DLG1,ANAPC10,PIK3R3,VDAC3,ANAPC7,RAN,POLE3,NFKB2,MYBL1,ATF2,RELA,PRKACB,DVL2,FZD1,MAP3K3,ATF4,AKT1,FZD4,TNFRSF13C,AKT2,CDC20,VDAC2,E2F3,ATF3,WNT11,DVL3,CDC23,CD40,VDAC1,FZD7,SMAD3,MSX2,XPO1,SMAD2,SLC25A4,FZD9,MAD2L1,SRF,GSK3B,PPP3CC,NRP1,E2F2,SMAD4,CRTC1,CDKN2B,ANAPC5,EGR1,TBP,TP53INP1,FZD8,TCF3,CRTC3,CHEK1,PPP3CB,ETS1,HLA-A,CALR,ATF1,CCND3,TSPO,RANBP1,BAX,MAP3K14,RRAS2,NFYB,MAP3K1,MSX1,RRAS,KAT2A,WNT10B,FZD3,PIK3R1,MYBL2,ANAPC2,POLD3,VAC14,CDC27,POLE,POLE2,ETS2,GPS2,IL6,XBP1,FDPS,PPP3R1,TBPL1,STAT5A,NFATC4,FZD5,CCNB2,MAP2K4,HRAS,POLD2,CDKN2A
hsa04068	FoxO signaling pathway	0.00111415466881332	-6.79965930616903	134	67	0.026346834447503	2543	6908	5599,2033,6517,100533105,5565,5894,5604,6648,51701,1147,1026,891,1387,4193,11337,3551,5296,10733,1027,8503,1032,901,23411,1263,6655,207,208,1454,9140,5571,8743,4088,8660,4087,4616,5594,4089,1030,673,10912,5562,3276,2309,9456,5601,6446,664,10018,5106,6774,5170,4303,6654,5295,6502,92579,5605,5595,847,2885,3643,51422,1647,3569,9133,3265,6789	MAPK8,EP300,SLC2A4,C8orf44-SGK3,PRKAB2,RAF1,MAP2K1,SOD2,NLK,CHUK,CDKN1A,CCNB1,CREBBP,MDM2,GABARAP,IKBKB,PIK3R2,PLK4,CDKN1B,PIK3R3,CDKN2D,CCNG2,SIRT1,PLK3,SOS2,AKT1,AKT2,CSNK1E,ATG12,PRKAG1,TNFSF10,SMAD3,IRS2,SMAD2,GADD45B,MAPK1,SMAD4,CDKN2B,BRAF,GADD45G,PRKAA1,PRMT1,FOXO3,HOMER1,MAPK9,SGK1,BNIP3,BCL2L11,PCK2,STAT3,PDPK1,FOXO4,SOS1,PIK3R1,SKP2,G6PC3,MAP2K2,MAPK3,CAT,GRB2,INSR,PRKAG2,GADD45A,IL6,CCNB2,HRAS,STK4
hsa03420	Nucleotide excision repair	0.00121619988313314	-6.71202413137008	47	28	0.011010617381046	2543	6908	5984,1643,2067,1161,5983,9978,2071,7508,8450,3978,2072,404672,10714,5424,5982,5886,4331,5111,5427,5426,2074,5887,2073,5981,54107,2068,5425,1642	RFC4,DDB2,ERCC1,ERCC8,RFC3,RBX1,ERCC3,XPC,CUL4B,LIG1,ERCC4,GTF2H5,POLD3,POLD1,RFC2,RAD23A,MNAT1,PCNA,POLE2,POLE,ERCC6,RAD23B,ERCC5,RFC1,POLE3,ERCC2,POLD2,DDB1
ko03420	Nucleotide excision repair	0.00121619988313314	-6.71202413137008	47	28	0.011010617381046	2543	6908	5984,1643,2067,5983,1161,7508,9978,2071,8450,3978,2072,404672,10714,5424,5982,5886,4331,5111,5426,5427,2074,5887,2073,2068,5981,54107,1642,5425	RFC4,DDB2,ERCC1,RFC3,ERCC8,XPC,RBX1,ERCC3,CUL4B,LIG1,ERCC4,GTF2H5,POLD3,POLD1,RFC2,RAD23A,MNAT1,PCNA,POLE,POLE2,ERCC6,RAD23B,ERCC5,ERCC2,RFC1,POLE3,DDB1,POLD2
ko03015	mRNA surveillance pathway	0.00130524552025713	-6.64136411777517	91	48	0.0188753440817932	2543	6908	65109,10250,7919,10978,10482,5520,23283,9887,22985,53981,5501,5519,55110,26528,29894,23381,9775,53918,26019,64895,5499,5521,11052,26986,65110,23293,29107,8731,1479,84305,10921,80335,5411,51585,5529,11051,5976,29101,1478,5500,5527,22916,10284,81608,55339,5528,23049,55916	UPF3B,SRRM1,DDX39B,CLP1,NXF1,PPP2R2A,CSTF2T,SMG7,ACIN1,CPSF2,PPP1CC,PPP2R1B,MAGOHB,DAZAP1,CPSF1,SMG5,EIF4A3,PELO,UPF2,PAPOLG,PPP1CA,PPP2R2B,CPSF6,PABPC1,UPF3A,SMG6,NXT1,RNMT,CSTF3,PYM1,RNPS1,WDR82,PNN,PCF11,PPP2R5E,NUDT21,UPF1,SSU72,CSTF2,PPP1CB,PPP2R5C,NCBP2,SAP18,FIP1L1,WDR33,PPP2R5D,SMG1,NXT2
hsa03015	mRNA surveillance pathway	0.00130524552025713	-6.64136411777517	91	48	0.0188753440817932	2543	6908	65109,10250,7919,10978,10482,5520,23283,9887,22985,53981,5501,5519,55110,26528,29894,23381,9775,53918,26019,64895,5499,5521,11052,26986,65110,23293,29107,8731,1479,84305,10921,80335,5411,51585,5529,11051,5976,29101,1478,5500,5527,22916,10284,81608,55339,5528,23049,55916	UPF3B,SRRM1,DDX39B,CLP1,NXF1,PPP2R2A,CSTF2T,SMG7,ACIN1,CPSF2,PPP1CC,PPP2R1B,MAGOHB,DAZAP1,CPSF1,SMG5,EIF4A3,PELO,UPF2,PAPOLG,PPP1CA,PPP2R2B,CPSF6,PABPC1,UPF3A,SMG6,NXT1,RNMT,CSTF3,PYM1,RNPS1,WDR82,PNN,PCF11,PPP2R5E,NUDT21,UPF1,SSU72,CSTF2,PPP1CB,PPP2R5C,NCBP2,SAP18,FIP1L1,WDR33,PPP2R5D,SMG1,NXT2
ko04144	Endocytosis	0.00169590279293916	-6.37954005873901	258	118	0.0464018875344082	2543	6908	26052,84440,8218,9230,51510,10565,2870,80230,8729,3303,8411,84612,30011,9372,58533,9727,4218,4193,23527,51324,8723,11021,10193,377,1785,118813,163,147179,116988,57132,10617,7879,83737,9525,5868,857,25978,51028,5869,29934,10890,4088,3305,23325,4087,64145,8976,9798,1213,80223,5590,7251,27183,382,23111,57154,409,1175,27131,92421,274,60682,81873,64411,1173,387680,11311,29924,11267,375,10093,84313,8766,7037,9559,3105,3799,26056,10092,50807,381,8724,829,5584,9922,11059,2065,93343,3482,9267,387,6643,9265,58513,9101,154,830,64750,55048,8394,10552,51100,3304,7852,22841,160,116985,138429,5337,832,30844,10109,23096,3265,5878,9135,51699,10564	DNM3,RAB11FIP4,CLTCL1,RAB11B,CHMP5,ARFGEF1,GRK6,RUFY1,GBF1,HSPA1A,EEA1,PARD6B,SH3KBP1,ZFYVE9,SNX6,RAB11FIP3,RAB8A,MDM2,ACAP2,SPG21,SNX4,RAB35,RNF41,ARF3,DNM2,ZFYVE27,AP2B1,WIPF2,AGAP3,CHMP1B,STAMBP,RAB7A,ITCH,VPS4B,RAB5A,CAV1,CHMP2B,VPS36,RAB5B,SNX12,RAB10,SMAD3,HSPA1L,KIAA1033,SMAD2,RBSN,WASL,IST1,CLTC,RAB11FIP1,PRKCZ,TSG101,VPS4A,ARF6,SPG20,SMURF1,ARRB2,AP2S1,SNX5,CHMP4C,BIN1,SMAP1,ARPC5L,ARAP3,AP2M1,FAM21A,VPS45,EPN1,SNF8,ARF1,ARPC4,VPS25,RAB11A,TFRC,VPS26A,HLA-A,KIF5B,RAB11FIP5,ARPC5,ASAP1,ARF5,SNX3,CAPZA1,PRKCI,IQSEC1,WWP1,ERBB3,MVB12A,IGF2R,CYTH1,RHOA,SNX2,CYTH3,EPS15L1,USP8,ADRB2,CAPZA2,SMURF2,VPS37C,PIP5K1A,ARPC1A,SH3GLB1,HSPA1B,CXCR4,RAB11FIP2,AP2A1,ARAP1,PIP5KL1,PLD1,CAPZB,EHD4,ARPC2,IQSEC2,HRAS,RAB5C,RABEP1,VPS29,ARFGEF2
hsa04144	Endocytosis	0.00169590279293916	-6.37954005873901	258	118	0.0464018875344082	2543	6908	26052,84440,8218,9230,51510,10565,2870,80230,8729,3303,8411,84612,30011,9372,58533,9727,4218,4193,23527,51324,8723,11021,10193,377,1785,118813,163,147179,116988,57132,10617,7879,83737,9525,5868,857,25978,51028,5869,29934,10890,4088,3305,23325,4087,64145,8976,9798,1213,80223,5590,7251,27183,382,23111,57154,409,1175,27131,92421,274,60682,81873,64411,1173,387680,11311,29924,11267,375,10093,84313,8766,7037,9559,3105,3799,26056,10092,50807,381,8724,829,5584,9922,11059,2065,93343,3482,9267,387,6643,9265,58513,9101,154,830,64750,55048,8394,10552,51100,3304,7852,22841,160,116985,138429,5337,832,30844,10109,23096,3265,5878,9135,51699,10564	DNM3,RAB11FIP4,CLTCL1,RAB11B,CHMP5,ARFGEF1,GRK6,RUFY1,GBF1,HSPA1A,EEA1,PARD6B,SH3KBP1,ZFYVE9,SNX6,RAB11FIP3,RAB8A,MDM2,ACAP2,SPG21,SNX4,RAB35,RNF41,ARF3,DNM2,ZFYVE27,AP2B1,WIPF2,AGAP3,CHMP1B,STAMBP,RAB7A,ITCH,VPS4B,RAB5A,CAV1,CHMP2B,VPS36,RAB5B,SNX12,RAB10,SMAD3,HSPA1L,KIAA1033,SMAD2,RBSN,WASL,IST1,CLTC,RAB11FIP1,PRKCZ,TSG101,VPS4A,ARF6,SPG20,SMURF1,ARRB2,AP2S1,SNX5,CHMP4C,BIN1,SMAP1,ARPC5L,ARAP3,AP2M1,FAM21A,VPS45,EPN1,SNF8,ARF1,ARPC4,VPS25,RAB11A,TFRC,VPS26A,HLA-A,KIF5B,RAB11FIP5,ARPC5,ASAP1,ARF5,SNX3,CAPZA1,PRKCI,IQSEC1,WWP1,ERBB3,MVB12A,IGF2R,CYTH1,RHOA,SNX2,CYTH3,EPS15L1,USP8,ADRB2,CAPZA2,SMURF2,VPS37C,PIP5K1A,ARPC1A,SH3GLB1,HSPA1B,CXCR4,RAB11FIP2,AP2A1,ARAP1,PIP5KL1,PLD1,CAPZB,EHD4,ARPC2,IQSEC2,HRAS,RAB5C,RABEP1,VPS29,ARFGEF2
ko01200	Carbon metabolism	0.00195621995717194	-6.23674126114993	113	57	0.0224144710971294	2543	6908	84706,113675,1962,4329,2026,8802,6391,10873,4191,3418,6120,128,5211,2806,230,2027,1431,8801,6472,4199,6888,4200,2098,3101,2731,84693,5160,5096,2597,1373,25796,29968,3419,1892,80201,5315,3417,1743,5226,6392,847,50,39,283871,5091,2539,226,38,4190,5224,3098,3420,5223,5723,7167,5214,22934	GPT2,SDSL,EHHADH,ALDH6A1,ENO2,SUCLG1,SDHC,ME3,MDH2,IDH2,RPE,ADH5,PFKL,GOT2,ALDOC,ENO3,CS,SUCLG2,SHMT2,ME1,TALDO1,ME2,ESD,HK3,GLDC,MCEE,PDHA1,PCCB,GAPDH,CPS1,PGLS,PSAT1,IDH3A,ECHS1,HKDC1,PKM,IDH1,DLST,PGD,SDHD,CAT,ACO2,ACAT2,PGP,PC,G6PD,ALDOA,ACAT1,MDH1,PGAM2,HK1,IDH3B,PGAM1,PSPH,TPI1,PFKP,RPIA
hsa01200	Carbon metabolism	0.00195621995717194	-6.23674126114993	113	57	0.0224144710971294	2543	6908	84706,113675,1962,4329,2026,8802,6391,10873,4191,3418,6120,128,5211,2806,230,2027,1431,8801,6472,4199,6888,4200,2098,3101,2731,84693,5160,5096,2597,1373,25796,29968,3419,1892,80201,5315,3417,1743,5226,6392,847,50,39,283871,5091,2539,226,38,4190,5224,3098,3420,5223,5723,7167,5214,22934	GPT2,SDSL,EHHADH,ALDH6A1,ENO2,SUCLG1,SDHC,ME3,MDH2,IDH2,RPE,ADH5,PFKL,GOT2,ALDOC,ENO3,CS,SUCLG2,SHMT2,ME1,TALDO1,ME2,ESD,HK3,GLDC,MCEE,PDHA1,PCCB,GAPDH,CPS1,PGLS,PSAT1,IDH3A,ECHS1,HKDC1,PKM,IDH1,DLST,PGD,SDHD,CAT,ACO2,ACAT2,PGP,PC,G6PD,ALDOA,ACAT1,MDH1,PGAM2,HK1,IDH3B,PGAM1,PSPH,TPI1,PFKP,RPIA
hsa05221	Acute myeloid leukemia	0.00221669015522898	-6.11174011669472	57	32	0.0125835627211954	2543	6908	6655,5914,673,207,3728,2475,6654,5894,208,5295,5604,6777,1050,1147,5605,6934,5595,2885,5467,1978,3551,5296,8503,6198,6776,861,5292,6774,5594,5970,3265,6199	SOS2,RARA,BRAF,AKT1,JUP,MTOR,SOS1,RAF1,AKT2,PIK3R1,MAP2K1,STAT5B,CEBPA,CHUK,MAP2K2,TCF7L2,MAPK3,GRB2,PPARD,EIF4EBP1,IKBKB,PIK3R2,PIK3R3,RPS6KB1,STAT5A,RUNX1,PIM1,STAT3,MAPK1,RELA,HRAS,RPS6KB2
ko05221	Acute myeloid leukemia	0.00221669015522898	-6.11174011669472	57	32	0.0125835627211954	2543	6908	6655,5914,673,207,3728,2475,6654,5894,208,5295,5604,6777,1050,1147,5605,6934,5595,2885,5467,1978,3551,5296,8503,6198,6776,861,5292,6774,5594,5970,3265,6199	SOS2,RARA,BRAF,AKT1,JUP,MTOR,SOS1,RAF1,AKT2,PIK3R1,MAP2K1,STAT5B,CEBPA,CHUK,MAP2K2,TCF7L2,MAPK3,GRB2,PPARD,EIF4EBP1,IKBKB,PIK3R2,PIK3R3,RPS6KB1,STAT5A,RUNX1,PIM1,STAT3,MAPK1,RELA,HRAS,RPS6KB2
ko05212	Pancreatic cancer	0.0023911443462457	-6.03598322166917	66	36	0.0141565080613449	2543	6908	5599,673,5894,10928,5879,5604,2064,5900,1147,598,5881,5899,3551,5296,5601,8503,6774,5970,1021,207,7039,208,842,5295,1871,7422,5595,5898,4088,4087,5888,5337,5594,1870,4089,1029	MAPK8,BRAF,RAF1,RALBP1,RAC1,MAP2K1,ERBB2,RALGDS,CHUK,BCL2L1,RAC3,RALB,IKBKB,PIK3R2,MAPK9,PIK3R3,STAT3,RELA,CDK6,AKT1,TGFA,AKT2,CASP9,PIK3R1,E2F3,VEGFA,MAPK3,RALA,SMAD3,SMAD2,RAD51,PLD1,MAPK1,E2F2,SMAD4,CDKN2A
hsa05212	Pancreatic cancer	0.0023911443462457	-6.03598322166917	66	36	0.0141565080613449	2543	6908	5599,673,5894,10928,5879,5604,2064,5900,1147,598,5881,5899,3551,5296,5601,8503,6774,5970,1021,207,7039,208,842,5295,1871,7422,5595,5898,4088,4087,5888,5337,5594,1870,4089,1029	MAPK8,BRAF,RAF1,RALBP1,RAC1,MAP2K1,ERBB2,RALGDS,CHUK,BCL2L1,RAC3,RALB,IKBKB,PIK3R2,MAPK9,PIK3R3,STAT3,RELA,CDK6,AKT1,TGFA,AKT2,CASP9,PIK3R1,E2F3,VEGFA,MAPK3,RALA,SMAD3,SMAD2,RAD51,PLD1,MAPK1,E2F2,SMAD4,CDKN2A
ko00051	Fructose and mannose metabolism	0.00273469275140921	-5.90173618894006	32	20	0.00786472670074715	2543	6908	5210,4351,197258,5208,80201,5373,29926,5372,57103,5211,230,226,231,29925,3098,55556,3101,3795,7167,5214	PFKFB4,MPI,FUK,PFKFB2,HKDC1,PMM2,GMPPA,PMM1,TIGAR,PFKL,ALDOC,ALDOA,AKR1B1,GMPPB,HK1,ENOSF1,HK3,KHK,TPI1,PFKP
hsa00051	Fructose and mannose metabolism	0.00273469275140921	-5.90173618894006	32	20	0.00786472670074715	2543	6908	5210,4351,197258,5208,80201,5373,29926,5372,57103,5211,230,226,29925,231,55556,3098,3101,3795,7167,5214	PFKFB4,MPI,FUK,PFKFB2,HKDC1,PMM2,GMPPA,PMM1,TIGAR,PFKL,ALDOC,ALDOA,GMPPB,AKR1B1,ENOSF1,HK1,HK3,KHK,TPI1,PFKP
hsa00630	Glyoxylate and dicarboxylate metabolism	0.00284013991061776	-5.86390196372044	28	18	0.00707825403067243	2543	6908	84693,5096,4191,81888,2752,847,9380,50,39,283871,1431,38,4190,6472,125061,2653,132158,2731	MCEE,PCCB,MDH2,HYI,GLUL,CAT,GRHPR,ACO2,ACAT2,PGP,CS,ACAT1,MDH1,SHMT2,AFMID,GCSH,GLYCTK,GLDC
ko00630	Glyoxylate and dicarboxylate metabolism	0.00284013991061776	-5.86390196372044	28	18	0.00707825403067243	2543	6908	84693,5096,4191,81888,2752,847,9380,50,39,283871,1431,38,4190,6472,125061,132158,2653,2731	MCEE,PCCB,MDH2,HYI,GLUL,CAT,GRHPR,ACO2,ACAT2,PGP,CS,ACAT1,MDH1,SHMT2,AFMID,GLYCTK,GCSH,GLDC
hsa04931	Insulin resistance	0.00383106337961455	-5.56461286951779	111	55	0.0216279984270547	2543	6908	5599,9945,6517,5837,2475,5565,5562,5507,1375,10488,7376,5501,5581,79660,6196,6945,3551,5296,5601,5781,10724,10999,8503,51085,5499,5106,6774,5970,6199,5170,2673,207,11001,208,5295,5465,5571,92579,9021,8660,5792,57761,51422,3643,3569,5524,5590,8473,5500,2932,6198,10891,9882,11000,6197	MAPK8,GFPT2,SLC2A4,PYGM,MTOR,PRKAB2,PRKAA1,PPP1R3C,CPT1B,CREB3,NR1H2,PPP1CC,PRKCE,PPP1R3B,RPS6KA2,MLX,IKBKB,PIK3R2,MAPK9,PTPN11,MGEA5,SLC27A4,PIK3R3,MLXIPL,PPP1CA,PCK2,STAT3,RELA,RPS6KB2,PDPK1,GFPT1,AKT1,SLC27A2,AKT2,PIK3R1,PPARA,PRKAG1,G6PC3,SOCS3,IRS2,PTPRF,TRIB3,PRKAG2,INSR,IL6,PPP2R4,PRKCZ,OGT,PPP1CB,GSK3B,RPS6KB1,PPARGC1A,TBC1D4,SLC27A3,RPS6KA3
hsa04142	Lysosome	0.00407871027770045	-5.50197444894561	123	60	0.0235941801022414	2543	6908	3916,9374,6272,8218,967,26088,8722,537,427,285362,4125,23062,8120,1200,9583,8763,1075,10239,8907,3373,23545,8906,130340,51606,9114,4668,175,3425,27074,51172,3482,53,11154,8905,10717,2629,8546,535,4891,9179,26503,10577,138050,1203,23431,4864,2517,3423,968,950,6448,10312,1213,23659,2720,527,2717,1201,164,3073	LAMP1,PPT2,SORT1,CLTCL1,CD63,GGA1,CTSF,ATP6AP1,ASAH1,SUMF1,MAN2B1,GGA2,AP3B2,TPP1,ENTPD4,CD164,CTSC,AP3S2,AP1M1,HYAL1,ATP6V0A2,AP1G2,AP1S3,ATP6V1H,ATP6V0D1,NAGA,AGA,IDUA,LAMP3,NAGPA,IGF2R,ACP2,AP4S1,AP1S2,AP4B1,GBA,AP3B1,ATP6V0A1,SLC11A2,AP4M1,SLC17A5,NPC2,HGSNAT,CLN5,AP4E1,NPC1,FUCA1,IDS,CD68,SCARB2,SGSH,TCIRG1,CLTC,PLA2G15,GLB1,ATP6V0C,GLA,CLN3,AP1G1,HEXA
ko04142	Lysosome	0.00407871027770045	-5.50197444894561	123	60	0.0235941801022414	2543	6908	3916,9374,6272,8218,967,26088,8722,537,427,285362,4125,23062,8120,1200,9583,8763,1075,10239,8907,3373,23545,8906,130340,51606,9114,4668,175,3425,27074,51172,3482,53,11154,8905,10717,2629,8546,535,4891,9179,26503,10577,138050,1203,23431,4864,2517,3423,968,950,6448,10312,1213,23659,2720,527,2717,1201,164,3073	LAMP1,PPT2,SORT1,CLTCL1,CD63,GGA1,CTSF,ATP6AP1,ASAH1,SUMF1,MAN2B1,GGA2,AP3B2,TPP1,ENTPD4,CD164,CTSC,AP3S2,AP1M1,HYAL1,ATP6V0A2,AP1G2,AP1S3,ATP6V1H,ATP6V0D1,NAGA,AGA,IDUA,LAMP3,NAGPA,IGF2R,ACP2,AP4S1,AP1S2,AP4B1,GBA,AP3B1,ATP6V0A1,SLC11A2,AP4M1,SLC17A5,NPC2,HGSNAT,CLN5,AP4E1,NPC1,FUCA1,IDS,CD68,SCARB2,SGSH,TCIRG1,CLTC,PLA2G15,GLB1,ATP6V0C,GLA,CLN3,AP1G1,HEXA
ko00520	Amino sugar and nucleotide sugar metabolism	0.00461838420032498	-5.37771037525125	48	27	0.0106173810460087	2543	6908	2673,5236,4351,9945,197258,55276,7360,64841,10007,10020,51167,7358,80201,51005,5373,29926,80146,5372,5238,29925,91373,132789,3098,3101,3073,1727,2582	GFPT1,PGM1,MPI,GFPT2,FUK,PGM2,UGP2,GNPNAT1,GNPDA1,GNE,CYB5R4,UGDH,HKDC1,AMDHD2,PMM2,GMPPA,UXS1,PMM1,PGM3,GMPPB,UAP1L1,GNPDA2,HK1,HK3,HEXA,CYB5R3,GALE
hsa01212	Fatty acid metabolism	0.00461838420032498	-5.37771037525125	48	27	0.0106173810460087	2543	6908	60481,9374,2180,1962,79071,79966,2181,1892,9200,2194,6319,1375,55825,30,39,201562,36,51,51102,10449,3032,27349,38,2182,9524,8310,31	ELOVL5,PPT2,ACSL1,EHHADH,ELOVL6,SCD5,ACSL3,ECHS1,HACD1,FASN,SCD,CPT1B,PECR,ACAA1,ACAT2,HACD2,ACADSB,ACOX1,MECR,ACAA2,HADHB,MCAT,ACAT1,ACSL4,TECR,ACOX3,ACACA
hsa00520	Amino sugar and nucleotide sugar metabolism	0.00461838420032498	-5.37771037525125	48	27	0.0106173810460087	2543	6908	2673,5236,4351,9945,197258,55276,7360,64841,10007,10020,51167,7358,80201,51005,5373,29926,80146,5372,5238,29925,91373,132789,3098,3101,3073,1727,2582	GFPT1,PGM1,MPI,GFPT2,FUK,PGM2,UGP2,GNPNAT1,GNPDA1,GNE,CYB5R4,UGDH,HKDC1,AMDHD2,PMM2,GMPPA,UXS1,PMM1,PGM3,GMPPB,UAP1L1,GNPDA2,HK1,HK3,HEXA,CYB5R3,GALE
ko01212	Fatty acid metabolism	0.00461838420032498	-5.37771037525125	48	27	0.0106173810460087	2543	6908	60481,9374,2180,1962,79071,79966,2181,1892,9200,2194,6319,1375,55825,30,39,201562,36,51,51102,10449,3032,27349,38,2182,9524,8310,31	ELOVL5,PPT2,ACSL1,EHHADH,ELOVL6,SCD5,ACSL3,ECHS1,HACD1,FASN,SCD,CPT1B,PECR,ACAA1,ACAT2,HACD2,ACADSB,ACOX1,MECR,ACAA2,HADHB,MCAT,ACAT1,ACSL4,TECR,ACOX3,ACACA
ko03020	RNA polymerase	0.00475715023999422	-5.34810647910152	31	19	0.00747149036570979	2543	6908	5438,5436,5441,5440,171568,5433,84265,51728,5430,11128,221830,5432,5434,55703,84172,9533,30834,64425,10621	POLR2I,POLR2G,POLR2L,POLR2K,POLR3H,POLR2D,POLR3GL,POLR3K,POLR2A,POLR3A,TWISTNB,POLR2C,POLR2E,POLR3B,POLR1B,POLR1C,ZNRD1,POLR1E,POLR3F
hsa03020	RNA polymerase	0.00475715023999422	-5.34810647910152	31	19	0.00747149036570979	2543	6908	5438,5436,5441,5440,171568,5433,84265,51728,11128,221830,5430,5432,5434,55703,84172,9533,30834,64425,10621	POLR2I,POLR2G,POLR2L,POLR2K,POLR3H,POLR2D,POLR3GL,POLR3K,POLR3A,TWISTNB,POLR2A,POLR2C,POLR2E,POLR3B,POLR1B,POLR1C,ZNRD1,POLR1E,POLR3F
hsa04012	ErbB signaling pathway	0.0057321204197876	-5.1616697608999	87	44	0.0173023987416437	2543	6908	5599,685,673,2475,5894,5604,2064,6777,1026,10298,25,1399,6464,5062,5296,5601,8503,1027,2065,6199,6655,207,5609,6654,4690,7039,208,5295,5747,5605,5595,2885,5335,817,1398,1978,2069,2932,6198,6776,5594,3265,6416,2549	MAPK8,BTC,BRAF,MTOR,RAF1,MAP2K1,ERBB2,STAT5B,CDKN1A,PAK4,ABL1,CRKL,SHC1,PAK2,PIK3R2,MAPK9,PIK3R3,CDKN1B,ERBB3,RPS6KB2,SOS2,AKT1,MAP2K7,SOS1,NCK1,TGFA,AKT2,PIK3R1,PTK2,MAP2K2,MAPK3,GRB2,PLCG1,CAMK2D,CRK,EIF4EBP1,EREG,GSK3B,RPS6KB1,STAT5A,MAPK1,HRAS,MAP2K4,GAB1
ko04012	ErbB signaling pathway	0.0057321204197876	-5.1616697608999	87	44	0.0173023987416437	2543	6908	5599,685,673,2475,5894,5604,2064,6777,1026,10298,25,1399,6464,5296,5601,5062,1027,8503,2065,6199,6655,5609,207,6654,4690,7039,208,5295,5747,5605,5595,2885,5335,817,1398,1978,2069,2932,6776,6198,5594,3265,6416,2549	MAPK8,BTC,BRAF,MTOR,RAF1,MAP2K1,ERBB2,STAT5B,CDKN1A,PAK4,ABL1,CRKL,SHC1,PIK3R2,MAPK9,PAK2,CDKN1B,PIK3R3,ERBB3,RPS6KB2,SOS2,MAP2K7,AKT1,SOS1,NCK1,TGFA,AKT2,PIK3R1,PTK2,MAP2K2,MAPK3,GRB2,PLCG1,CAMK2D,CRK,EIF4EBP1,EREG,GSK3B,STAT5A,RPS6KB1,MAPK1,HRAS,MAP2K4,GAB1
hsa04914	Progesterone-mediated oocyte maturation	0.0057321204197876	-5.1616697608999	87	44	0.0173023987416437	2543	6908	5599,51433,673,80315,5894,5604,891,5566,10459,64682,6196,890,5296,51343,51529,5601,115,10393,8379,8503,699,51434,3320,2771,5567,993,207,208,3326,5295,29882,9088,8697,995,2773,983,5595,2770,996,4085,5594,9133,132864,6197	MAPK8,ANAPC5,BRAF,CPEB4,RAF1,MAP2K1,CCNB1,PRKACA,MAD2L2,ANAPC1,RPS6KA2,CCNA2,PIK3R2,FZR1,ANAPC11,MAPK9,ADCY9,ANAPC10,MAD1L1,PIK3R3,BUB1,ANAPC7,HSP90AA1,GNAI2,PRKACB,CDC25A,AKT1,AKT2,HSP90AB1,PIK3R1,ANAPC2,PKMYT1,CDC23,CDC25C,GNAI3,CDK1,MAPK3,GNAI1,CDC27,MAD2L1,MAPK1,CCNB2,CPEB2,RPS6KA3
ko04914	Progesterone-mediated oocyte maturation	0.0057321204197876	-5.1616697608999	87	44	0.0173023987416437	2543	6908	5599,51433,673,80315,5894,5604,891,5566,10459,64682,6196,890,5296,51343,51529,5601,115,10393,8379,8503,699,51434,3320,2771,5567,993,207,208,3326,5295,29882,9088,8697,995,2773,983,5595,2770,996,4085,5594,9133,132864,6197	MAPK8,ANAPC5,BRAF,CPEB4,RAF1,MAP2K1,CCNB1,PRKACA,MAD2L2,ANAPC1,RPS6KA2,CCNA2,PIK3R2,FZR1,ANAPC11,MAPK9,ADCY9,ANAPC10,MAD1L1,PIK3R3,BUB1,ANAPC7,HSP90AA1,GNAI2,PRKACB,CDC25A,AKT1,AKT2,HSP90AB1,PIK3R1,ANAPC2,PKMYT1,CDC23,CDC25C,GNAI3,CDK1,MAPK3,GNAI1,CDC27,MAD2L1,MAPK1,CCNB2,CPEB2,RPS6KA3
hsa05100	Bacterial invasion of epithelial cells	0.00607968541391613	-5.10280232547489	78	40	0.0157294534014943	2543	6908	10163,391,26052,81873,8218,8936,71,1495,5879,10093,10459,1399,6464,1499,23607,63916,10092,5296,1785,55752,8503,2017,7414,387,10801,5295,3678,857,5747,10552,9564,26084,1398,8976,1213,3688,60,10109,79658,2549	WASF2,RHOG,DNM3,ARPC5L,CLTCL1,WASF1,ACTG1,CTNNA1,RAC1,ARPC4,MAD2L2,CRKL,SHC1,CTNNB1,CD2AP,ELMO2,ARPC5,PIK3R2,DNM2,SEPT11,PIK3R3,CTTN,VCL,RHOA,SEPT9,PIK3R1,ITGA5,CAV1,PTK2,ARPC1A,BCAR1,ARHGEF26,CRK,WASL,CLTC,ITGB1,ACTB,ARPC2,ARHGAP10,GAB1
ko05100	Bacterial invasion of epithelial cells	0.00607968541391613	-5.10280232547489	78	40	0.0157294534014943	2543	6908	10163,391,26052,81873,8218,8936,71,1495,5879,10093,10459,1399,6464,1499,23607,63916,10092,5296,1785,55752,8503,2017,7414,387,10801,5295,3678,857,5747,10552,9564,26084,1398,8976,1213,3688,60,10109,79658,2549	WASF2,RHOG,DNM3,ARPC5L,CLTCL1,WASF1,ACTG1,CTNNA1,RAC1,ARPC4,MAD2L2,CRKL,SHC1,CTNNB1,CD2AP,ELMO2,ARPC5,PIK3R2,DNM2,SEPT11,PIK3R3,CTTN,VCL,RHOA,SEPT9,PIK3R1,ITGA5,CAV1,PTK2,ARPC1A,BCAR1,ARHGEF26,CRK,WASL,CLTC,ITGB1,ACTB,ARPC2,ARHGAP10,GAB1
ko04666	Fc gamma R-mediated phagocytosis	0.00630012569806087	-5.06718569371054	92	46	0.0180888714117184	2543	6908	274,10163,81873,3636,8936,5894,5879,7410,5604,8877,10093,4067,1399,5581,8611,7408,50807,10092,5296,1785,8503,4082,8398,3985,6199,207,4651,208,5295,8612,65108,8394,10552,1073,5595,5335,2934,1398,8976,3984,6198,5337,10109,382,5594,56848	BIN1,WASF2,ARPC5L,INPPL1,WASF1,RAF1,RAC1,VAV2,MAP2K1,SPHK1,ARPC4,LYN,CRKL,PRKCE,PLPP1,VASP,ASAP1,ARPC5,PIK3R2,DNM2,PIK3R3,MARCKS,PLA2G6,LIMK2,RPS6KB2,AKT1,MYO10,AKT2,PIK3R1,PLPP2,MARCKSL1,PIP5K1A,ARPC1A,CFL2,MAPK3,PLCG1,GSN,CRK,WASL,LIMK1,RPS6KB1,PLD1,ARPC2,ARF6,MAPK1,SPHK2
hsa04666	Fc gamma R-mediated phagocytosis	0.00630012569806087	-5.06718569371054	92	46	0.0180888714117184	2543	6908	274,10163,81873,3636,8936,5894,5879,7410,5604,8877,10093,4067,1399,5581,8611,7408,50807,10092,5296,1785,8503,4082,8398,3985,6199,207,4651,208,5295,8612,65108,8394,10552,1073,5595,5335,2934,1398,8976,3984,6198,5337,10109,382,5594,56848	BIN1,WASF2,ARPC5L,INPPL1,WASF1,RAF1,RAC1,VAV2,MAP2K1,SPHK1,ARPC4,LYN,CRKL,PRKCE,PLPP1,VASP,ASAP1,ARPC5,PIK3R2,DNM2,PIK3R3,MARCKS,PLA2G6,LIMK2,RPS6KB2,AKT1,MYO10,AKT2,PIK3R1,PLPP2,MARCKSL1,PIP5K1A,ARPC1A,CFL2,MAPK3,PLCG1,GSN,CRK,WASL,LIMK1,RPS6KB1,PLD1,ARPC2,ARF6,MAPK1,SPHK2
hsa04150	mTOR signaling pathway	0.0064136026188784	-5.04933413490357	60	32	0.0125835627211954	2543	6908	673,7249,2475,92335,5562,64121,8408,54541,57521,6196,3551,5296,6194,8503,253260,1977,6199,64223,5170,207,208,5295,7422,6009,5595,3091,1978,10325,6198,5594,6197,58528	BRAF,TSC2,MTOR,STRADA,PRKAA1,RRAGC,ULK1,DDIT4,RPTOR,RPS6KA2,IKBKB,PIK3R2,RPS6,PIK3R3,RICTOR,EIF4E,RPS6KB2,MLST8,PDPK1,AKT1,AKT2,PIK3R1,VEGFA,RHEB,MAPK3,HIF1A,EIF4EBP1,RRAGB,RPS6KB1,MAPK1,RPS6KA3,RRAGD
ko04150	mTOR signaling pathway	0.0064136026188784	-5.04933413490357	60	32	0.0125835627211954	2543	6908	673,7249,2475,92335,5562,64121,8408,54541,57521,6196,3551,5296,6194,8503,253260,1977,6199,64223,5170,207,208,5295,7422,6009,5595,3091,1978,10325,6198,5594,6197,58528	BRAF,TSC2,MTOR,STRADA,PRKAA1,RRAGC,ULK1,DDIT4,RPTOR,RPS6KA2,IKBKB,PIK3R2,RPS6,PIK3R3,RICTOR,EIF4E,RPS6KB2,MLST8,PDPK1,AKT1,AKT2,PIK3R1,VEGFA,RHEB,MAPK3,HIF1A,EIF4EBP1,RRAGB,RPS6KB1,MAPK1,RPS6KA3,RRAGD
hsa04390	Hippo signaling pathway	0.00670061479700063	-5.00555599604861	154	72	0.0283130161226897	2543	6908	23291,3397,71,5520,324,64398,7531,2535,329,84612,5519,7474,1490,1499,1739,7004,7159,5499,5521,55233,1741,1856,6591,8463,8321,8322,1454,1742,10971,10413,9113,7481,1857,60485,8324,7532,10207,4088,4087,8326,25937,5590,5500,2932,60,657,4086,4089,656,659,8325,1495,11186,3398,5501,654,6788,3993,268,3996,896,5584,7480,7003,7976,286204,23286,23513,6934,7534,7855,7533	FBXW11,ID1,ACTG1,PPP2R2A,APC,MPP5,YWHAE,FZD2,BIRC2,PARD6B,PPP2R1B,WNT5A,CTGF,CTNNB1,DLG1,TEAD4,TP53BP2,PPP1CA,PPP2R2B,MOB1A,DLG3,DVL2,SNAI2,TEAD2,FZD1,FZD4,CSNK1E,DLG4,YWHAQ,YAP1,LATS1,WNT11,DVL3,SAV1,FZD7,YWHAG,INADL,SMAD3,SMAD2,FZD9,WWTR1,PRKCZ,PPP1CB,GSK3B,ACTB,BMPR1A,SMAD1,SMAD4,BMP8B,BMPR2,FZD8,CTNNA1,RASSF1,ID2,PPP1CC,BMP6,STK3,LLGL2,AMH,LLGL1,CCND3,PRKCI,WNT10B,TEAD1,FZD3,CRB2,WWC1,SCRIB,TCF7L2,YWHAZ,FZD5,YWHAH
ko04390	Hippo signaling pathway	0.00670061479700063	-5.00555599604861	154	72	0.0283130161226897	2543	6908	23291,3397,71,5520,324,64398,7531,2535,329,84612,5519,7474,1490,1499,1739,7004,7159,5499,5521,55233,1741,1856,6591,8463,8321,8322,1454,1742,10971,10413,9113,7481,1857,60485,8324,7532,10207,4088,4087,8326,25937,5590,5500,2932,60,657,4086,4089,656,659,8325,1495,11186,3398,5501,654,6788,3993,268,3996,896,5584,7480,7003,7976,286204,23286,23513,6934,7534,7855,7533	FBXW11,ID1,ACTG1,PPP2R2A,APC,MPP5,YWHAE,FZD2,BIRC2,PARD6B,PPP2R1B,WNT5A,CTGF,CTNNB1,DLG1,TEAD4,TP53BP2,PPP1CA,PPP2R2B,MOB1A,DLG3,DVL2,SNAI2,TEAD2,FZD1,FZD4,CSNK1E,DLG4,YWHAQ,YAP1,LATS1,WNT11,DVL3,SAV1,FZD7,YWHAG,INADL,SMAD3,SMAD2,FZD9,WWTR1,PRKCZ,PPP1CB,GSK3B,ACTB,BMPR1A,SMAD1,SMAD4,BMP8B,BMPR2,FZD8,CTNNA1,RASSF1,ID2,PPP1CC,BMP6,STK3,LLGL2,AMH,LLGL1,CCND3,PRKCI,WNT10B,TEAD1,FZD3,CRB2,WWC1,SCRIB,TCF7L2,YWHAZ,FZD5,YWHAH
hsa03030	DNA replication	0.00686792310599339	-4.98089353199191	36	21	0.00825796303578451	2543	6908	5984,4175,5983,5558,5422,3978,10714,5424,5982,246243,5557,5111,5427,5426,1763,5981,6742,10535,54107,5425,4172	RFC4,MCM6,RFC3,PRIM2,POLA1,LIG1,POLD3,POLD1,RFC2,RNASEH1,PRIM1,PCNA,POLE2,POLE,DNA2,RFC1,SSBP1,RNASEH2A,POLE3,POLD2,MCM3
ko03030	DNA replication	0.00686792310599339	-4.98089353199191	36	21	0.00825796303578451	2543	6908	5984,5983,4175,5558,5422,3978,10714,5424,5982,246243,5557,5111,5426,5427,1763,5981,54107,10535,6742,4172,5425	RFC4,RFC3,MCM6,PRIM2,POLA1,LIG1,POLD3,POLD1,RFC2,RNASEH1,PRIM1,PCNA,POLE,POLE2,DNA2,RFC1,POLE3,RNASEH2A,SSBP1,MCM3,POLD2
hsa05205	Proteoglycans in cancer	0.00710992744427606	-4.94626323996223	203	92	0.0361777428234369	2543	6908	836,71,2475,8826,5894,5879,5604,2064,22808,1026,3709,2535,6382,5566,7474,4193,1499,5296,54776,6194,8503,2017,5499,10818,5567,8321,6655,84309,207,8322,208,5777,287,5727,7430,7481,857,3710,7422,2260,8324,117581,817,5335,4087,10855,3673,8326,3688,5500,60,6198,6093,5594,2549,673,4659,967,8325,7410,3693,5501,7057,7023,9138,5781,6548,2065,22800,6774,9475,6199,5170,387,6237,7480,6654,7976,5295,3678,23365,5747,5605,5595,2885,3091,3708,4660,1655,3685,7855,3265	CASP3,ACTG1,MTOR,IQGAP1,RAF1,RAC1,MAP2K1,ERBB2,MRAS,CDKN1A,ITPR2,FZD2,SDC1,PRKACA,WNT5A,MDM2,CTNNB1,PIK3R2,PPP1R12C,RPS6,PIK3R3,CTTN,PPP1CA,FRS2,PRKACB,FZD1,SOS2,NUDT16L1,AKT1,FZD4,AKT2,PTPN6,ANK2,PTCH1,EZR,WNT11,CAV1,ITPR3,VEGFA,FGFR1,FZD7,TWIST2,CAMK2D,PLCG1,SMAD2,HPSE,ITGA2,FZD9,ITGB1,PPP1CB,ACTB,RPS6KB1,ROCK1,MAPK1,GAB1,BRAF,PPP1R12A,CD63,FZD8,VAV2,ITGB5,PPP1CC,THBS1,TFAP4,ARHGEF1,PTPN11,SLC9A1,ERBB3,RRAS2,STAT3,ROCK2,RPS6KB2,PDPK1,RHOA,RRAS,WNT10B,SOS1,FZD3,PIK3R1,ITGA5,ARHGEF12,PTK2,MAP2K2,MAPK3,GRB2,HIF1A,ITPR1,PPP1R12B,DDX5,ITGAV,FZD5,HRAS
ko05205	Proteoglycans in cancer	0.00710992744427606	-4.94626323996223	203	92	0.0361777428234369	2543	6908	836,71,2475,8826,5894,5879,5604,2064,22808,1026,3709,2535,6382,5566,7474,4193,1499,5296,54776,6194,8503,2017,5499,10818,5567,8321,6655,84309,207,8322,208,5777,287,5727,7430,7481,857,3710,7422,2260,8324,117581,817,5335,4087,10855,3673,8326,3688,5500,60,6198,6093,5594,2549,673,4659,967,8325,7410,3693,5501,7057,7023,9138,5781,6548,2065,22800,6774,9475,6199,5170,387,6237,7480,6654,7976,5295,3678,23365,5747,5605,5595,2885,3091,3708,4660,1655,3685,7855,3265	CASP3,ACTG1,MTOR,IQGAP1,RAF1,RAC1,MAP2K1,ERBB2,MRAS,CDKN1A,ITPR2,FZD2,SDC1,PRKACA,WNT5A,MDM2,CTNNB1,PIK3R2,PPP1R12C,RPS6,PIK3R3,CTTN,PPP1CA,FRS2,PRKACB,FZD1,SOS2,NUDT16L1,AKT1,FZD4,AKT2,PTPN6,ANK2,PTCH1,EZR,WNT11,CAV1,ITPR3,VEGFA,FGFR1,FZD7,TWIST2,CAMK2D,PLCG1,SMAD2,HPSE,ITGA2,FZD9,ITGB1,PPP1CB,ACTB,RPS6KB1,ROCK1,MAPK1,GAB1,BRAF,PPP1R12A,CD63,FZD8,VAV2,ITGB5,PPP1CC,THBS1,TFAP4,ARHGEF1,PTPN11,SLC9A1,ERBB3,RRAS2,STAT3,ROCK2,RPS6KB2,PDPK1,RHOA,RRAS,WNT10B,SOS1,FZD3,PIK3R1,ITGA5,ARHGEF12,PTK2,MAP2K2,MAPK3,GRB2,HIF1A,ITPR1,PPP1R12B,DDX5,ITGAV,FZD5,HRAS
hsa03022	Basal transcription factors	0.00781565556246892	-4.85162643347409	45	25	0.00983090837593394	2543	6908	129685,6884,6881,6877,6872,2071,6908,9569,404672,6875,2962,4331,6873,8148,2957,83860,2963,9519,6879,6883,6882,2068,2959,2969,6878	TAF8,TAF13,TAF10,TAF5,TAF1,ERCC3,TBP,GTF2IRD1,GTF2H5,TAF4B,GTF2F1,MNAT1,TAF2,TAF15,GTF2A1,TAF3,GTF2F2,TBPL1,TAF7,TAF12,TAF11,ERCC2,GTF2B,GTF2I,TAF6
ko03022	Basal transcription factors	0.00781565556246892	-4.85162643347409	45	25	0.00983090837593394	2543	6908	129685,6881,6884,6877,6908,6872,2071,9569,6875,404672,2962,8148,4331,6873,2957,83860,2963,9519,6879,6883,2068,6882,2959,2969,6878	TAF8,TAF10,TAF13,TAF5,TBP,TAF1,ERCC3,GTF2IRD1,TAF4B,GTF2H5,GTF2F1,TAF15,MNAT1,TAF2,GTF2A1,TAF3,GTF2F2,TBPL1,TAF7,TAF12,ERCC2,TAF11,GTF2B,GTF2I,TAF6
hsa00310	Lysine degradation	0.00883871335126233	-4.72861396142553	52	28	0.011010617381046	2543	6908	55870,1962,55904,1892,7468,79709,54904,2639,1743,51111,39,83852,84787,79723,51166,5352,387893,79823,38,9757,85007,8985,4297,224,6839,55217,223,9869	ASH1L,EHHADH,KMT2E,ECHS1,WHSC1,COLGALT1,WHSC1L1,GCDH,DLST,KMT5B,ACAT2,SETDB2,KMT5C,SUV39H2,AADAT,PLOD2,KMT5A,CAMKMT,ACAT1,KMT2B,PHYKPL,PLOD3,KMT2A,ALDH3A2,SUV39H1,TMLHE,ALDH9A1,SETDB1
ko00310	Lysine degradation	0.00883871335126233	-4.72861396142553	52	28	0.011010617381046	2543	6908	55870,1962,55904,1892,79709,7468,54904,2639,1743,39,51111,79723,51166,84787,83852,5352,387893,79823,38,9757,85007,8985,4297,224,6839,55217,9869,223	ASH1L,EHHADH,KMT2E,ECHS1,COLGALT1,WHSC1,WHSC1L1,GCDH,DLST,ACAT2,KMT5B,SUV39H2,AADAT,KMT5C,SETDB2,PLOD2,KMT5A,CAMKMT,ACAT1,KMT2B,PHYKPL,PLOD3,KMT2A,ALDH3A2,SUV39H1,TMLHE,SETDB1,ALDH9A1
ko04722	Neurotrophin signaling pathway	0.0100378226310067	-4.60139505765977	120	57	0.0224144710971294	2543	6908	5599,6272,673,5607,5894,5879,5604,808,814,7531,9252,2309,25,1399,5906,6196,6464,3551,5296,51135,5601,5664,581,5781,8503,5598,5970,10818,4214,4215,5170,6655,387,468,207,5609,6654,208,5295,5908,5605,5595,2885,5335,817,57498,1398,27018,25970,396,2932,4793,4217,5594,3265,2549,6197	MAPK8,SORT1,BRAF,MAP2K5,RAF1,RAC1,MAP2K1,CALM3,CAMK4,YWHAE,RPS6KA5,FOXO3,ABL1,CRKL,RAP1A,RPS6KA2,SHC1,IKBKB,PIK3R2,IRAK4,MAPK9,PSEN2,BAX,PTPN11,PIK3R3,MAPK7,RELA,FRS2,MAP3K1,MAP3K3,PDPK1,SOS2,RHOA,ATF4,AKT1,MAP2K7,SOS1,AKT2,PIK3R1,RAP1B,MAP2K2,MAPK3,GRB2,PLCG1,CAMK2D,KIDINS220,CRK,NGFRAP1,SH2B1,ARHGDIA,GSK3B,NFKBIB,MAP3K5,MAPK1,HRAS,GAB1,RPS6KA3
hsa04722	Neurotrophin signaling pathway	0.0100378226310067	-4.60139505765977	120	57	0.0224144710971294	2543	6908	5599,6272,673,5607,5894,5879,5604,808,814,7531,9252,2309,25,1399,5906,6196,6464,3551,5296,51135,5601,5664,581,5781,8503,5598,5970,10818,4214,4215,5170,6655,387,468,207,5609,6654,208,5295,5908,5605,5595,2885,5335,817,57498,1398,27018,25970,396,2932,4793,4217,5594,3265,2549,6197	MAPK8,SORT1,BRAF,MAP2K5,RAF1,RAC1,MAP2K1,CALM3,CAMK4,YWHAE,RPS6KA5,FOXO3,ABL1,CRKL,RAP1A,RPS6KA2,SHC1,IKBKB,PIK3R2,IRAK4,MAPK9,PSEN2,BAX,PTPN11,PIK3R3,MAPK7,RELA,FRS2,MAP3K1,MAP3K3,PDPK1,SOS2,RHOA,ATF4,AKT1,MAP2K7,SOS1,AKT2,PIK3R1,RAP1B,MAP2K2,MAPK3,GRB2,PLCG1,CAMK2D,KIDINS220,CRK,NGFRAP1,SH2B1,ARHGDIA,GSK3B,NFKBIB,MAP3K5,MAPK1,HRAS,GAB1,RPS6KA3
hsa01230	Biosynthesis of amino acids	0.0103145718879566	-4.57419763715381	73	37	0.0145497443963822	2543	6908	84706,113675,2026,435,3418,6120,2752,587,51166,2806,5211,65263,230,2027,1431,6472,6888,5832,1491,2597,1373,29968,3419,5315,3417,4144,5831,50,5091,226,5224,3420,5223,5723,5214,7167,22934	GPT2,SDSL,ENO2,ASL,IDH2,RPE,GLUL,BCAT2,AADAT,GOT2,PFKL,PYCRL,ALDOC,ENO3,CS,SHMT2,TALDO1,ALDH18A1,CTH,GAPDH,CPS1,PSAT1,IDH3A,PKM,IDH1,MAT2A,PYCR1,ACO2,PC,ALDOA,PGAM2,IDH3B,PGAM1,PSPH,PFKP,TPI1,RPIA
ko01230	Biosynthesis of amino acids	0.0103145718879566	-4.57419763715381	73	37	0.0145497443963822	2543	6908	84706,113675,2026,435,3418,6120,2752,587,51166,2806,5211,65263,230,2027,1431,6472,6888,5832,1491,2597,1373,29968,3419,5315,3417,4144,5831,50,5091,226,5224,3420,5223,5723,5214,7167,22934	GPT2,SDSL,ENO2,ASL,IDH2,RPE,GLUL,BCAT2,AADAT,GOT2,PFKL,PYCRL,ALDOC,ENO3,CS,SHMT2,TALDO1,ALDH18A1,CTH,GAPDH,CPS1,PSAT1,IDH3A,PKM,IDH1,MAT2A,PYCR1,ACO2,PC,ALDOA,PGAM2,IDH3B,PGAM1,PSPH,PFKP,TPI1,RPIA
ko04330	Notch signaling pathway	0.0103679838225393	-4.56903269969951	48	26	0.0102241447109713	2543	6908	2033,3280,6868,54567,2648,51107,3955,9541,1857,1488,83464,1387,22938,9253,182,23220,5664,3065,3516,9794,23385,1487,1856,3066,8650,55534	EP300,HES1,ADAM17,DLL4,KAT2A,APH1A,LFNG,CIR1,DVL3,CTBP2,APH1B,CREBBP,SNW1,NUMBL,JAG1,DTX4,PSEN2,HDAC1,RBPJ,MAML1,NCSTN,CTBP1,DVL2,HDAC2,NUMB,MAML3
hsa04330	Notch signaling pathway	0.0103679838225393	-4.56903269969951	48	26	0.0102241447109713	2543	6908	2033,3280,6868,54567,2648,51107,3955,9541,1857,1488,83464,1387,22938,9253,182,23220,5664,3065,3516,9794,23385,1487,1856,3066,8650,55534	EP300,HES1,ADAM17,DLL4,KAT2A,APH1A,LFNG,CIR1,DVL3,CTBP2,APH1B,CREBBP,SNW1,NUMBL,JAG1,DTX4,PSEN2,HDAC1,RBPJ,MAML1,NCSTN,CTBP1,DVL2,HDAC2,NUMB,MAML3
hsa04919	Thyroid hormone signaling pathway	0.0108865251410759	-4.5202294800936	118	56	0.022021234762092	2543	6908	2033,71,7249,2475,5894,6256,1734,5604,25942,5566,29079,1387,4193,488,1499,5296,8503,9968,6548,5469,5567,5170,7068,207,2648,5208,2626,208,842,8841,5295,10025,481,5605,6009,9969,5595,6257,5335,8202,476,3091,3065,2932,482,60,9440,3685,9282,9611,9882,5594,3265,117247,3066,5214	EP300,ACTG1,TSC2,MTOR,RAF1,RXRA,DIO2,MAP2K1,SIN3A,PRKACA,MED4,CREBBP,MDM2,ATP2A2,CTNNB1,PIK3R2,PIK3R3,MED12,SLC9A1,MED1,PRKACB,PDPK1,THRB,AKT1,KAT2A,PFKFB2,GATA4,AKT2,CASP9,HDAC3,PIK3R1,MED16,ATP1B1,MAP2K2,RHEB,MED13,MAPK3,RXRB,PLCG1,NCOA3,ATP1A1,HIF1A,HDAC1,GSK3B,ATP1B2,ACTB,MED17,ITGAV,MED14,NCOR1,TBC1D4,MAPK1,HRAS,SLC16A10,HDAC2,PFKP
ko05110	Vibrio cholerae infection	0.0122648942204941	-4.40101422580997	53	28	0.011010617381046	2543	6908	71,523,30001,537,535,7082,375,5566,11014,9601,2778,5335,51382,10312,29927,115,23545,60,527,528,51606,6558,529,9114,8992,5567,55176,9550	ACTG1,ATP6V1A,ERO1A,ATP6AP1,ATP6V0A1,TJP1,ARF1,PRKACA,KDELR2,PDIA4,GNAS,PLCG1,ATP6V1D,TCIRG1,SEC61A1,ADCY9,ATP6V0A2,ACTB,ATP6V0C,ATP6V1C1,ATP6V1H,SLC12A2,ATP6V1E1,ATP6V0D1,ATP6V0E1,PRKACB,SEC61A2,ATP6V1G1
hsa05110	Vibrio cholerae infection	0.0122648942204941	-4.40101422580997	53	28	0.011010617381046	2543	6908	71,523,30001,537,535,7082,375,5566,11014,9601,2778,5335,51382,10312,29927,115,23545,60,527,528,51606,6558,529,9114,8992,5567,55176,9550	ACTG1,ATP6V1A,ERO1A,ATP6AP1,ATP6V0A1,TJP1,ARF1,PRKACA,KDELR2,PDIA4,GNAS,PLCG1,ATP6V1D,TCIRG1,SEC61A1,ADCY9,ATP6V0A2,ACTB,ATP6V0C,ATP6V1C1,ATP6V1H,SLC12A2,ATP6V1E1,ATP6V0D1,ATP6V0E1,PRKACB,SEC61A2,ATP6V1G1
hsa00450	Selenocompound metabolism	0.0180225370916773	-4.01613224361152	17	11	0.00432559968541093	2543	6908	7296,883,92935,9061,56267,51091,10587,1491,51540,114112,22929	TXNRD1,CCBL1,MARS2,PAPSS1,CCBL2,SEPSECS,TXNRD2,CTH,SCLY,TXNRD3,SEPHS1
ko00450	Selenocompound metabolism	0.0180225370916773	-4.01613224361152	17	11	0.00432559968541093	2543	6908	7296,883,92935,9061,56267,51091,10587,1491,51540,114112,22929	TXNRD1,CCBL1,MARS2,PAPSS1,CCBL2,SEPSECS,TXNRD2,CTH,SCLY,TXNRD3,SEPHS1
hsa05200	Pathways in cancer	0.0195854433270374	-3.93296867607063	397	166	0.0652772316162013	2543	6908	836,2034,6256,2782,6777,1488,1050,1026,2535,329,23566,5881,898,1387,1499,4286,5296,10342,1021,5567,5468,9978,7039,208,842,83593,7422,2773,2770,5898,5335,4087,1398,59345,3688,4254,3065,2932,6093,861,9618,1870,3066,3728,1495,5900,27148,2122,5601,3913,2771,9475,7423,5915,3915,6921,26060,5605,2767,1613,6934,6257,2778,5888,3091,9063,5337,1288,1487,1029,5599,2033,2785,2475,10928,5894,5879,5604,2064,1147,324,598,5566,2783,7474,1399,4193,5899,115,3551,1027,8503,4791,841,112399,5970,1856,1164,8321,6655,5914,207,330,6923,7170,8322,3326,2257,5734,1871,5727,1857,7481,8324,2260,4088,5743,7185,112398,3673,8326,5594,10672,4089,1030,9170,4824,673,8325,7186,11186,2113,25,57449,2737,10681,9138,581,1163,3320,6774,2956,387,7480,6654,7976,5295,6502,23365,5747,2323,5595,2885,5467,7175,2768,7852,8031,3569,8453,4437,6776,3685,7855,3265,6789	CASP3,EPAS1,RXRA,GNB1,STAT5B,CTBP2,CEBPA,CDKN1A,FZD2,BIRC2,LPAR3,RAC3,CCNE1,CREBBP,CTNNB1,MITF,PIK3R2,TFG,CDK6,PRKACB,PPARG,RBX1,TGFA,AKT2,CASP9,RASSF5,VEGFA,GNAI3,GNAI1,RALA,PLCG1,SMAD2,CRK,GNB4,ITGB1,KITLG,HDAC1,GSK3B,ROCK1,RUNX1,TRAF4,E2F2,HDAC2,JUP,CTNNA1,RALGDS,STK36,MECOM,MAPK9,LAMB2,GNAI2,ROCK2,VEGFB,RARB,LAMC1,TCEB1,APPL1,MAP2K2,GNA11,DAPK3,TCF7L2,RXRB,GNAS,RAD51,HIF1A,PIAS2,PLD1,COL4A6,CTBP1,CDKN2A,MAPK8,EP300,GNG3,MTOR,RALBP1,RAF1,RAC1,MAP2K1,ERBB2,CHUK,APC,BCL2L1,PRKACA,GNB2,WNT5A,CRKL,MDM2,RALB,ADCY9,IKBKB,CDKN1B,PIK3R3,NFKB2,CASP8,EGLN3,RELA,DVL2,CKS2,FZD1,SOS2,RARA,AKT1,BIRC3,TCEB2,TPM3,FZD4,HSP90AB1,FGF12,PTGER4,E2F3,PTCH1,DVL3,WNT11,FZD7,FGFR1,SMAD3,PTGS2,TRAF1,EGLN2,ITGA2,FZD9,MAPK1,GNA13,SMAD4,CDKN2B,LPAR2,NKX3-1,BRAF,FZD8,TRAF2,RASSF1,ETS1,ABL1,PLEKHG5,GLI3,GNB5,ARHGEF1,BAX,CKS1B,HSP90AA1,STAT3,MSH6,RHOA,WNT10B,SOS1,FZD3,PIK3R1,SKP2,ARHGEF12,PTK2,FLT3LG,MAPK3,GRB2,PPARD,TPR,GNA12,CXCR4,NCOA4,IL6,CUL2,MSH3,STAT5A,ITGAV,FZD5,HRAS,STK4
ko05130	Pathogenic Escherichia coli infection	0.0222851396629115	-3.80383520547687	55	28	0.011010617381046	2543	6908	9076,387,7280,81873,71,4690,10383,10971,7430,4691,10093,10552,25,2534,1499,10092,8976,3688,9181,7534,60,2017,6093,10109,3875,9475,203068,10381	CLDN1,RHOA,TUBB2A,ARPC5L,ACTG1,NCK1,TUBB4B,YWHAQ,EZR,NCL,ARPC4,ARPC1A,ABL1,FYN,CTNNB1,ARPC5,WASL,ITGB1,ARHGEF2,YWHAZ,ACTB,CTTN,ROCK1,ARPC2,KRT18,ROCK2,TUBB,TUBB3
hsa05130	Pathogenic Escherichia coli infection	0.0222851396629115	-3.80383520547687	55	28	0.011010617381046	2543	6908	9076,387,7280,81873,71,4690,10383,10971,7430,4691,10093,10552,25,2534,1499,10092,8976,3688,9181,7534,60,2017,6093,10109,3875,9475,203068,10381	CLDN1,RHOA,TUBB2A,ARPC5L,ACTG1,NCK1,TUBB4B,YWHAQ,EZR,NCL,ARPC4,ARPC1A,ABL1,FYN,CTNNB1,ARPC5,WASL,ITGB1,ARHGEF2,YWHAZ,ACTB,CTTN,ROCK1,ARPC2,KRT18,ROCK2,TUBB,TUBB3
ko05230	Central carbon metabolism in cancer	0.0244041104386573	-3.71300370027017	67	33	0.0129767990562328	2543	6908	2475,5894,5604,9123,2064,9997,57103,5211,5296,8503,3101,5160,207,5163,51548,208,5295,80201,5315,3417,5605,2260,5595,2744,3091,2539,5224,3098,6510,5223,5594,3265,5214	MTOR,RAF1,MAP2K1,SLC16A3,ERBB2,SCO2,TIGAR,PFKL,PIK3R2,PIK3R3,HK3,PDHA1,AKT1,PDK1,SIRT6,AKT2,PIK3R1,HKDC1,PKM,IDH1,MAP2K2,FGFR1,MAPK3,GLS,HIF1A,G6PD,PGAM2,HK1,SLC1A5,PGAM1,MAPK1,HRAS,PFKP
hsa05230	Central carbon metabolism in cancer	0.0244041104386573	-3.71300370027017	67	33	0.0129767990562328	2543	6908	2475,5894,5604,9123,2064,9997,57103,5211,5296,8503,3101,5160,207,5163,51548,208,5295,80201,5315,3417,5605,2260,5595,2744,3091,2539,5224,3098,6510,5223,5594,3265,5214	MTOR,RAF1,MAP2K1,SLC16A3,ERBB2,SCO2,TIGAR,PFKL,PIK3R2,PIK3R3,HK3,PDHA1,AKT1,PDK1,SIRT6,AKT2,PIK3R1,HKDC1,PKM,IDH1,MAP2K2,FGFR1,MAPK3,GLS,HIF1A,G6PD,PGAM2,HK1,SLC1A5,PGAM1,MAPK1,HRAS,PFKP
ko04350	TGF-beta signaling pathway	0.0267290252215458	-3.62200521707779	84	40	0.0157294534014943	2543	6908	1030,656,2033,3397,90,659,1875,3398,8454,4090,654,9372,5519,7057,1387,268,9241,92,4091,6199,6667,7050,387,9978,64750,5595,5308,4088,3399,4087,25805,1874,7027,6198,657,6093,4086,57154,5594,4089	CDKN2B,BMP8B,EP300,ID1,ACVR1,BMPR2,E2F5,ID2,CUL1,SMAD5,BMP6,ZFYVE9,PPP2R1B,THBS1,CREBBP,AMH,NOG,ACVR2A,SMAD6,RPS6KB2,SP1,TGIF1,RHOA,RBX1,SMURF2,MAPK3,PITX2,SMAD3,ID3,SMAD2,BAMBI,E2F4,TFDP1,RPS6KB1,BMPR1A,ROCK1,SMAD1,SMURF1,MAPK1,SMAD4
hsa04350	TGF-beta signaling pathway	0.0267290252215458	-3.62200521707779	84	40	0.0157294534014943	2543	6908	1030,656,2033,3397,90,659,1875,3398,8454,4090,654,9372,5519,7057,1387,268,9241,92,4091,6199,6667,7050,387,9978,64750,5595,5308,4088,3399,4087,25805,1874,7027,6198,657,6093,4086,57154,5594,4089	CDKN2B,BMP8B,EP300,ID1,ACVR1,BMPR2,E2F5,ID2,CUL1,SMAD5,BMP6,ZFYVE9,PPP2R1B,THBS1,CREBBP,AMH,NOG,ACVR2A,SMAD6,RPS6KB2,SP1,TGIF1,RHOA,RBX1,SMURF2,MAPK3,PITX2,SMAD3,ID3,SMAD2,BAMBI,E2F4,TFDP1,RPS6KB1,BMPR1A,ROCK1,SMAD1,SMURF1,MAPK1,SMAD4
ko00900	Terpenoid backbone biosynthesis	0.0276234877121601	-3.58908886409392	22	13	0.00511207235548565	2543	6908	79947,3157,39,3422,2339,9986,2224,38,10654,9453,23590,3156,10269	DHDDS,HMGCS1,ACAT2,IDI1,FNTA,RCE1,FDPS,ACAT1,PMVK,GGPS1,PDSS1,HMGCR,ZMPSTE24
hsa00900	Terpenoid backbone biosynthesis	0.0276234877121601	-3.58908886409392	22	13	0.00511207235548565	2543	6908	79947,3422,3157,39,2339,9986,2224,38,9453,10654,3156,10269,23590	DHDDS,IDI1,HMGCS1,ACAT2,FNTA,RCE1,FDPS,ACAT1,GGPS1,PMVK,HMGCR,ZMPSTE24,PDSS1
hsa04152	AMPK signaling pathway	0.0280393593603644	-3.57414606442467	123	56	0.022021234762092	2543	6908	51552,6517,7249,2475,9230,84254,5565,92335,79966,5562,79602,5520,5862,6319,8408,1375,10488,2309,5519,57521,4218,890,1938,5211,5296,8503,5521,5106,31,3156,6199,5210,23411,5170,207,5208,5468,208,5295,2194,5571,92579,10890,6009,8660,5529,51422,3643,1994,1978,5527,51094,6198,10891,5528,5214	RAB14,SLC2A4,TSC2,MTOR,RAB11B,CAMKK1,PRKAB2,STRADA,SCD5,PRKAA1,ADIPOR2,PPP2R2A,RAB2A,SCD,ULK1,CPT1B,CREB3,FOXO3,PPP2R1B,RPTOR,RAB8A,CCNA2,EEF2,PFKL,PIK3R2,PIK3R3,PPP2R2B,PCK2,ACACA,HMGCR,RPS6KB2,PFKFB4,SIRT1,PDPK1,AKT1,PFKFB2,PPARG,AKT2,PIK3R1,FASN,PRKAG1,G6PC3,RAB10,RHEB,IRS2,PPP2R5E,PRKAG2,INSR,ELAVL1,EIF4EBP1,PPP2R5C,ADIPOR1,RPS6KB1,PPARGC1A,PPP2R5D,PFKP
ko04152	AMPK signaling pathway	0.0280393593603644	-3.57414606442467	123	56	0.022021234762092	2543	6908	51552,6517,7249,2475,9230,84254,5565,92335,79966,5562,79602,5520,5862,6319,8408,1375,10488,2309,5519,57521,4218,890,1938,5211,5296,8503,5521,5106,31,3156,6199,5210,23411,5170,207,5208,5468,208,5295,2194,5571,92579,10890,6009,8660,5529,51422,3643,1994,1978,5527,51094,6198,10891,5528,5214	RAB14,SLC2A4,TSC2,MTOR,RAB11B,CAMKK1,PRKAB2,STRADA,SCD5,PRKAA1,ADIPOR2,PPP2R2A,RAB2A,SCD,ULK1,CPT1B,CREB3,FOXO3,PPP2R1B,RPTOR,RAB8A,CCNA2,EEF2,PFKL,PIK3R2,PIK3R3,PPP2R2B,PCK2,ACACA,HMGCR,RPS6KB2,PFKFB4,SIRT1,PDPK1,AKT1,PFKFB2,PPARG,AKT2,PIK3R1,FASN,PRKAG1,G6PC3,RAB10,RHEB,IRS2,PPP2R5E,PRKAG2,INSR,ELAVL1,EIF4EBP1,PPP2R5C,ADIPOR1,RPS6KB1,PPARGC1A,PPP2R5D,PFKP
hsa00563	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis	0.0392148145048932	-3.2387006825367	25	14	0.005505308690523	2543	6908	5279,8818,284098,10026,51227,5283,54872,8733,9488,84720,9487,80055,5281,55650	PIGC,DPM2,PIGW,PIGK,PIGP,PIGH,PIGG,GPAA1,PIGB,PIGO,PIGL,PGAP1,PIGF,PIGV
hsa00062	Fatty acid elongation	0.0392148145048932	-3.2387006825367	25	14	0.005505308690523	2543	6908	60481,9374,201562,79071,83401,1892,3032,10449,9200,51102,9524,64834,641371,11332	ELOVL5,PPT2,HACD2,ELOVL6,ELOVL3,ECHS1,HADHB,ACAA2,HACD1,MECR,TECR,ELOVL1,ACOT1,ACOT7
ko00563	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis	0.0392148145048932	-3.2387006825367	25	14	0.005505308690523	2543	6908	5279,8818,284098,10026,51227,5283,54872,9488,8733,84720,9487,80055,5281,55650	PIGC,DPM2,PIGW,PIGK,PIGP,PIGH,PIGG,PIGB,GPAA1,PIGO,PIGL,PGAP1,PIGF,PIGV
ko00062	Fatty acid elongation	0.0392148145048932	-3.2387006825367	25	14	0.005505308690523	2543	6908	60481,9374,201562,79071,83401,1892,9200,3032,10449,51102,9524,64834,641371,11332	ELOVL5,PPT2,HACD2,ELOVL6,ELOVL3,ECHS1,HACD1,HADHB,ACAA2,MECR,TECR,ELOVL1,ACOT1,ACOT7
hsa04066	HIF-1 signaling pathway	0.0399115030614762	-3.22109069935589	103	47	0.0184821077467558	2543	6908	2033,2026,2475,5604,2064,1026,7037,1387,5211,2027,5296,6194,2872,1027,8503,112399,3459,3101,6774,5970,1977,6199,5160,2597,5163,6923,207,9978,208,5295,6921,80201,7422,5605,5595,5335,817,3643,112398,3091,3569,1978,8453,226,6198,3098,5594	EP300,ENO2,MTOR,MAP2K1,ERBB2,CDKN1A,TFRC,CREBBP,PFKL,ENO3,PIK3R2,RPS6,MKNK2,CDKN1B,PIK3R3,EGLN3,IFNGR1,HK3,STAT3,RELA,EIF4E,RPS6KB2,PDHA1,GAPDH,PDK1,TCEB2,AKT1,RBX1,AKT2,PIK3R1,TCEB1,HKDC1,VEGFA,MAP2K2,MAPK3,PLCG1,CAMK2D,INSR,EGLN2,HIF1A,IL6,EIF4EBP1,CUL2,ALDOA,RPS6KB1,HK1,MAPK1
hsa05134	Legionellosis	0.0412458320553434	-3.18820521238903	55	27	0.0106173810460087	2543	6908	836,1195,2921,842,3297,3606,2920,375,5861,23786,1915,3303,3304,51128,3305,3592,840,56681,3569,81876,9554,664,317,841,4791,3329,5970	CASP3,CLK1,CXCL3,CASP9,HSF1,IL18,CXCL2,ARF1,RAB1A,BCL2L13,EEF1A1,HSPA1A,HSPA1B,SAR1B,HSPA1L,IL12A,CASP7,SAR1A,IL6,RAB1B,SEC22B,BNIP3,APAF1,CASP8,NFKB2,HSPD1,RELA
ko05134	Legionellosis	0.0412458320553434	-3.18820521238903	55	27	0.0106173810460087	2543	6908	836,1195,2921,842,3297,3606,2920,375,5861,23786,1915,3303,3304,51128,3305,3592,840,56681,3569,81876,9554,664,317,841,4791,3329,5970	CASP3,CLK1,CXCL3,CASP9,HSF1,IL18,CXCL2,ARF1,RAB1A,BCL2L13,EEF1A1,HSPA1A,HSPA1B,SAR1B,HSPA1L,IL12A,CASP7,SAR1A,IL6,RAB1B,SEC22B,BNIP3,APAF1,CASP8,NFKB2,HSPD1,RELA
hsa03060	Protein export	0.0425173700019723	-3.15784258062053	23	13	0.00511207235548565	2543	6908	83943,6726,6731,6734,29927,6730,7095,6729,11231,196294,6728,6727,55176	IMMP2L,SRP9,SRP72,SRPR,SEC61A1,SRP68,SEC62,SRP54,SEC63,IMMP1L,SRP19,SRP14,SEC61A2
ko03430	Mismatch repair	0.0425173700019723	-3.15784258062053	23	13	0.00511207235548565	2543	6908	9156,5984,5983,5111,4437,3978,5981,6742,10714,5982,5424,2956,5425	EXO1,RFC4,RFC3,PCNA,MSH3,LIG1,RFC1,SSBP1,POLD3,RFC2,POLD1,MSH6,POLD2
ko03060	Protein export	0.0425173700019723	-3.15784258062053	23	13	0.00511207235548565	2543	6908	6726,6731,83943,29927,6734,6730,7095,6729,11231,196294,6728,6727,55176	SRP9,SRP72,IMMP2L,SEC61A1,SRPR,SRP68,SEC62,SRP54,SEC63,IMMP1L,SRP19,SRP14,SEC61A2
ko01040	Biosynthesis of unsaturated fatty acids	0.0425173700019723	-3.15784258062053	23	13	0.00511207235548565	2543	6908	60481,201562,51,79966,79071,9200,6319,55825,9524,30,8310,641371,11332	ELOVL5,HACD2,ACOX1,SCD5,ELOVL6,HACD1,SCD,PECR,TECR,ACAA1,ACOX3,ACOT1,ACOT7
hsa01040	Biosynthesis of unsaturated fatty acids	0.0425173700019723	-3.15784258062053	23	13	0.00511207235548565	2543	6908	60481,201562,79966,79071,51,9200,6319,55825,9524,30,8310,641371,11332	ELOVL5,HACD2,SCD5,ELOVL6,ACOX1,HACD1,SCD,PECR,TECR,ACAA1,ACOX3,ACOT1,ACOT7
hsa03430	Mismatch repair	0.0425173700019723	-3.15784258062053	23	13	0.00511207235548565	2543	6908	9156,5984,5111,5983,4437,3978,5981,6742,10714,5424,5982,2956,5425	EXO1,RFC4,PCNA,RFC3,MSH3,LIG1,RFC1,SSBP1,POLD3,POLD1,RFC2,MSH6,POLD2
ko00020	Citrate cycle (TCA cycle)	0.0474791562442415	-3.04746448016012	30	16	0.00629178136059772	2543	6908	5160,8802,6391,3419,4191,3418,3417,1743,6392,50,5091,1431,8801,4190,5106,3420	PDHA1,SUCLG1,SDHC,IDH3A,MDH2,IDH2,IDH1,DLST,SDHD,ACO2,PC,CS,SUCLG2,MDH1,PCK2,IDH3B
hsa00020	Citrate cycle (TCA cycle)	0.0474791562442415	-3.04746448016012	30	16	0.00629178136059772	2543	6908	5160,8802,6391,4191,3419,3418,1743,3417,6392,50,5091,1431,8801,4190,5106,3420	PDHA1,SUCLG1,SDHC,MDH2,IDH3A,IDH2,DLST,IDH1,SDHD,ACO2,PC,CS,SUCLG2,MDH1,PCK2,IDH3B
ko04920	Adipocytokine signaling pathway	0.0483046895326627	-3.03022663126316	70	33	0.0129767990562328	2543	6908	5599,2180,6517,2475,84254,7186,5565,6256,5562,79602,1147,1375,3551,5601,5781,3717,2182,5106,6774,5970,207,208,2181,5465,5571,92579,6257,9021,8660,51422,51094,10891,4793	MAPK8,ACSL1,SLC2A4,MTOR,CAMKK1,TRAF2,PRKAB2,RXRA,PRKAA1,ADIPOR2,CHUK,CPT1B,IKBKB,MAPK9,PTPN11,JAK2,ACSL4,PCK2,STAT3,RELA,AKT1,AKT2,ACSL3,PPARA,PRKAG1,G6PC3,RXRB,SOCS3,IRS2,PRKAG2,ADIPOR1,PPARGC1A,NFKBIB
hsa04920	Adipocytokine signaling pathway	0.0483046895326627	-3.03022663126316	70	33	0.0129767990562328	2543	6908	5599,2180,6517,2475,84254,7186,5565,6256,5562,79602,1147,1375,3551,5601,5781,3717,2182,5106,6774,5970,207,208,2181,5465,5571,92579,6257,9021,8660,51422,51094,10891,4793	MAPK8,ACSL1,SLC2A4,MTOR,CAMKK1,TRAF2,PRKAB2,RXRA,PRKAA1,ADIPOR2,CHUK,CPT1B,IKBKB,MAPK9,PTPN11,JAK2,ACSL4,PCK2,STAT3,RELA,AKT1,AKT2,ACSL3,PPARA,PRKAG1,G6PC3,RXRB,SOCS3,IRS2,PRKAG2,ADIPOR1,PPARGC1A,NFKBIB
hsa05202	Transcriptional misregulation in cancer	0.0489240663208714	-3.01748584976822	179	77	0.0302791977978765	2543	6908	7403,6256,5087,8358,8350,1050,598,1026,25942,1031,79058,4193,2120,1027,4297,2118,5970,4211,3486,7709,8352,5914,330,5468,64083,958,905,3087,7185,8351,3065,64332,2521,861,4086,3020,30012,4300,3066,2130,55204,3728,5966,4291,6929,2119,3398,3207,7102,51804,55589,3206,466,6495,653604,4299,4613,6667,8968,8861,221037,7468,5747,4221,6692,8357,6257,8148,8464,3569,4066,7030,5546,1655,9611,1649,8354	KDM6A,RXRA,PBX1,HIST1H3B,HIST1H3A,CEBPA,BCL2L1,CDKN1A,SIN3A,CDKN2C,ASPSCR1,MDM2,ETV6,CDKN1B,KMT2A,ETV4,RELA,MEIS1,IGFBP3,ZBTB17,HIST1H3C,RARA,BIRC3,PPARG,GOLPH3,CD40,CCNT2,HHEX,TRAF1,HIST1H3D,HDAC1,NFKBIZ,FUS,RUNX1,SMAD1,H3F3A,TLX3,MLLT3,HDAC2,EWSR1,GOLPH3L,JUP,REL,MLF1,TCF3,ETV5,ID2,HOXA11,TSPAN7,SIX4,BMP2K,HOXA10,ATF1,SIX1,HIST2H3D,AFF1,MYCN,SP1,HIST1H3F,LDB1,JMJD1C,WHSC1,PTK2,MEN1,SPINT1,HIST1H3H,RXRB,TAF15,SUPT3H,IL6,LYL1,TFE3,PRCC,DDX5,NCOR1,DDIT3,HIST1H3I
ko05202	Transcriptional misregulation in cancer	0.0489240663208714	-3.01748584976822	179	77	0.0302791977978765	2543	6908	7403,6256,5087,8358,8350,1050,598,1026,25942,1031,79058,4193,2120,1027,4297,2118,5970,4211,3486,7709,8352,5914,330,5468,64083,958,905,3087,7185,8351,3065,64332,2521,861,4086,3020,30012,4300,3066,2130,55204,3728,5966,4291,6929,2119,3398,3207,7102,51804,55589,3206,466,6495,653604,4299,4613,6667,8968,8861,221037,7468,5747,4221,6692,8357,6257,8148,8464,3569,4066,7030,5546,1655,9611,1649,8354	KDM6A,RXRA,PBX1,HIST1H3B,HIST1H3A,CEBPA,BCL2L1,CDKN1A,SIN3A,CDKN2C,ASPSCR1,MDM2,ETV6,CDKN1B,KMT2A,ETV4,RELA,MEIS1,IGFBP3,ZBTB17,HIST1H3C,RARA,BIRC3,PPARG,GOLPH3,CD40,CCNT2,HHEX,TRAF1,HIST1H3D,HDAC1,NFKBIZ,FUS,RUNX1,SMAD1,H3F3A,TLX3,MLLT3,HDAC2,EWSR1,GOLPH3L,JUP,REL,MLF1,TCF3,ETV5,ID2,HOXA11,TSPAN7,SIX4,BMP2K,HOXA10,ATF1,SIX1,HIST2H3D,AFF1,MYCN,SP1,HIST1H3F,LDB1,JMJD1C,WHSC1,PTK2,MEN1,SPINT1,HIST1H3H,RXRB,TAF15,SUPT3H,IL6,LYL1,TFE3,PRCC,DDX5,NCOR1,DDIT3,HIST1H3I
ko00785	Lipoic acid metabolism	0.0498492022448913	-2.99875278581385	3	3	0.00117970900511207	2543	6908	51601,11019,387787	LIPT1,LIAS,LIPT2
hsa00785	Lipoic acid metabolism	0.0498492022448913	-2.99875278581385	3	3	0.00117970900511207	2543	6908	51601,11019,387787	LIPT1,LIAS,LIPT2
ko01210	2-Oxocarboxylic acid metabolism	0.0536685098348156	-2.92492885850743	17	10	0.00393236335037357	2543	6908	84706,50,51166,2806,3419,1431,3418,3420,3417,587	GPT2,ACO2,AADAT,GOT2,IDH3A,CS,IDH2,IDH3B,IDH1,BCAT2
hsa01210	2-Oxocarboxylic acid metabolism	0.0536685098348156	-2.92492885850743	17	10	0.00393236335037357	2543	6908	84706,50,51166,2806,3419,1431,3418,3420,3417,587	GPT2,ACO2,AADAT,GOT2,IDH3A,CS,IDH2,IDH3B,IDH1,BCAT2
ko00510	N-Glycan biosynthesis	0.0539343018688204	-2.91998860517436	49	24	0.00943767204089658	2543	6908	79796,8813,10905,6480,79087,79053,7841,1798,54344,10195,4122,8818,1650,4245,199857,79868,1603,22845,440138,201595,85365,8704,144245,56052	ALG9,DPM1,MAN1A2,ST6GAL1,ALG12,ALG8,MOGS,DPAGT1,DPM3,ALG3,MAN2A2,DPM2,DDOST,MGAT1,ALG14,ALG13,DAD1,DOLK,ALG11,STT3B,ALG2,B4GALT2,ALG10B,ALG1
hsa00510	N-Glycan biosynthesis	0.0539343018688204	-2.91998860517436	49	24	0.00943767204089658	2543	6908	79796,8813,10905,6480,79087,79053,7841,1798,54344,4122,10195,8818,1650,4245,199857,1603,79868,22845,440138,85365,201595,8704,144245,56052	ALG9,DPM1,MAN1A2,ST6GAL1,ALG12,ALG8,MOGS,DPAGT1,DPM3,MAN2A2,ALG3,DPM2,DDOST,MGAT1,ALG14,DAD1,ALG13,DOLK,ALG11,ALG2,STT3B,B4GALT2,ALG10B,ALG1
hsa00280	Valine, leucine and isoleucine degradation	0.059043326542122	-2.82948375640655	47	23	0.00904443570585922	2543	6908	84693,5096,1962,4329,593,594,65985,1892,3028,56922,30,587,39,3157,36,10449,3032,38,3155,27034,1629,224,223	MCEE,PCCB,EHHADH,ALDH6A1,BCKDHA,BCKDHB,AACS,ECHS1,HSD17B10,MCCC1,ACAA1,BCAT2,ACAT2,HMGCS1,ACADSB,ACAA2,HADHB,ACAT1,HMGCL,ACAD8,DBT,ALDH3A2,ALDH9A1
ko00280	Valine, leucine and isoleucine degradation	0.059043326542122	-2.82948375640655	47	23	0.00904443570585922	2543	6908	84693,5096,1962,4329,593,594,65985,1892,3028,56922,30,587,39,3157,36,10449,3032,38,3155,27034,1629,224,223	MCEE,PCCB,EHHADH,ALDH6A1,BCKDHA,BCKDHB,AACS,ECHS1,HSD17B10,MCCC1,ACAA1,BCAT2,ACAT2,HMGCS1,ACADSB,ACAA2,HADHB,ACAT1,HMGCL,ACAD8,DBT,ALDH3A2,ALDH9A1
hsa05161	Hepatitis B	0.0655047880966655	-2.72563203830021	146	63	0.0247738891073535	2543	6908	5599,2033,836,1388,5894,5604,537,1147,6777,3661,1960,10488,1026,898,10542,1387,5111,890,3551,5296,5601,581,1027,8503,7419,841,1386,6774,5970,1021,4214,1643,29110,468,207,208,842,5295,1871,10971,3454,5605,6773,5595,2885,4088,1654,3569,6778,2185,148022,6776,7534,317,4776,1870,64135,5594,6416,4089,3265,1642,114609	MAPK8,EP300,CASP3,ATF6B,RAF1,MAP2K1,ATP6AP1,CHUK,STAT5B,IRF3,EGR3,CREB3,CDKN1A,CCNE1,LAMTOR5,CREBBP,PCNA,CCNA2,IKBKB,PIK3R2,MAPK9,BAX,CDKN1B,PIK3R3,VDAC3,CASP8,ATF2,STAT3,RELA,CDK6,MAP3K1,DDB2,TBK1,ATF4,AKT1,AKT2,CASP9,PIK3R1,E2F3,YWHAQ,IFNAR1,MAP2K2,STAT2,MAPK3,GRB2,SMAD3,DDX3X,IL6,STAT6,PTK2B,TICAM1,STAT5A,YWHAZ,APAF1,NFATC4,E2F2,IFIH1,MAPK1,MAP2K4,SMAD4,HRAS,DDB1,TIRAP
ko05210	Colorectal cancer	0.0680823378122199	-2.68703745611418	62	29	0.0114038537160834	2543	6908	5599,836,387,673,207,5894,208,5295,5879,842,5604,5900,324,26060,5881,6934,5595,4088,4087,1499,5601,5296,4437,581,8503,2932,5594,4089,2956	MAPK8,CASP3,RHOA,BRAF,AKT1,RAF1,AKT2,PIK3R1,RAC1,CASP9,MAP2K1,RALGDS,APC,APPL1,RAC3,TCF7L2,MAPK3,SMAD3,SMAD2,CTNNB1,MAPK9,PIK3R2,MSH3,BAX,PIK3R3,GSK3B,MAPK1,SMAD4,MSH6
hsa05210	Colorectal cancer	0.0680823378122199	-2.68703745611418	62	29	0.0114038537160834	2543	6908	5599,836,387,673,207,5894,208,5295,5879,842,5604,5900,324,26060,5881,6934,5595,4088,4087,1499,5601,5296,4437,581,8503,2932,5594,4089,2956	MAPK8,CASP3,RHOA,BRAF,AKT1,RAF1,AKT2,PIK3R1,RAC1,CASP9,MAP2K1,RALGDS,APC,APPL1,RAC3,TCF7L2,MAPK3,SMAD3,SMAD2,CTNNB1,MAPK9,PIK3R2,MSH3,BAX,PIK3R3,GSK3B,MAPK1,SMAD4,MSH6
hsa05215	Prostate cancer	0.0693261836818579	-2.66893261323936	89	40	0.0157294534014943	2543	6908	2033,673,4824,2475,5894,5604,2064,1147,1026,10488,898,1387,4193,1499,3551,5296,8503,1027,3320,5970,5170,6655,468,207,6654,7039,208,3326,842,5295,1871,5605,2260,6934,5595,2885,2932,5594,1870,3265	EP300,BRAF,NKX3-1,MTOR,RAF1,MAP2K1,ERBB2,CHUK,CDKN1A,CREB3,CCNE1,CREBBP,MDM2,CTNNB1,IKBKB,PIK3R2,PIK3R3,CDKN1B,HSP90AA1,RELA,PDPK1,SOS2,ATF4,AKT1,SOS1,TGFA,AKT2,HSP90AB1,CASP9,PIK3R1,E2F3,MAP2K2,FGFR1,TCF7L2,MAPK3,GRB2,GSK3B,MAPK1,E2F2,HRAS
ko05215	Prostate cancer	0.0693261836818579	-2.66893261323936	89	40	0.0157294534014943	2543	6908	2033,673,4824,2475,5894,5604,2064,1147,1026,10488,898,1387,4193,1499,3551,5296,8503,1027,3320,5970,5170,6655,468,207,6654,7039,208,3326,842,5295,1871,5605,2260,6934,5595,2885,2932,5594,1870,3265	EP300,BRAF,NKX3-1,MTOR,RAF1,MAP2K1,ERBB2,CHUK,CDKN1A,CREB3,CCNE1,CREBBP,MDM2,CTNNB1,IKBKB,PIK3R2,PIK3R3,CDKN1B,HSP90AA1,RELA,PDPK1,SOS2,ATF4,AKT1,SOS1,TGFA,AKT2,HSP90AB1,CASP9,PIK3R1,E2F3,MAP2K2,FGFR1,TCF7L2,MAPK3,GRB2,GSK3B,MAPK1,E2F2,HRAS
ko05216	Thyroid cancer	0.0719124603717959	-2.63230572785429	29	15	0.00589854502556036	2543	6908	7175,673,7170,1499,5468,8031,6256,5604,10342,5594,3265,5605,6934,5595,6257	TPR,BRAF,TPM3,CTNNB1,PPARG,NCOA4,RXRA,MAP2K1,TFG,MAPK1,HRAS,MAP2K2,TCF7L2,MAPK3,RXRB
hsa05216	Thyroid cancer	0.0719124603717959	-2.63230572785429	29	15	0.00589854502556036	2543	6908	7175,673,7170,1499,5468,8031,6256,5604,10342,5594,3265,5605,6934,5595,6257	TPR,BRAF,TPM3,CTNNB1,PPARG,NCOA4,RXRA,MAP2K1,TFG,MAPK1,HRAS,MAP2K2,TCF7L2,MAPK3,RXRB
hsa00670	One carbon pool by folate	0.0746700667139858	-2.59467598048393	20	11	0.00432559968541093	2543	6908	10797,10588,123263,471,1719,7298,6472,25902,200895,441024,4522	MTHFD2,MTHFS,MTFMT,ATIC,DHFR,TYMS,SHMT2,MTHFD1L,DHFRL1,MTHFD2L,MTHFD1
ko00670	One carbon pool by folate	0.0746700667139858	-2.59467598048393	20	11	0.00432559968541093	2543	6908	10797,10588,123263,471,1719,7298,6472,25902,200895,441024,4522	MTHFD2,MTHFS,MTFMT,ATIC,DHFR,TYMS,SHMT2,MTHFD1L,DHFRL1,MTHFD2L,MTHFD1
ko04930	Type II diabetes mellitus	0.0749931071701855	-2.59035907406682	48	23	0.00904443570585922	2543	6908	5599,6517,2475,8913,5295,8835,80201,5315,5595,9021,5581,8660,3643,8651,5601,5296,3551,5590,8503,3767,3098,3101,5594	MAPK8,SLC2A4,MTOR,CACNA1G,PIK3R1,SOCS2,HKDC1,PKM,MAPK3,SOCS3,PRKCE,IRS2,INSR,SOCS1,MAPK9,PIK3R2,IKBKB,PRKCZ,PIK3R3,KCNJ11,HK1,HK3,MAPK1
hsa04930	Type II diabetes mellitus	0.0749931071701855	-2.59035907406682	48	23	0.00904443570585922	2543	6908	5599,6517,2475,8913,5295,8835,80201,5315,5595,9021,5581,8660,3643,8651,5601,5296,3551,5590,8503,3767,3098,3101,5594	MAPK8,SLC2A4,MTOR,CACNA1G,PIK3R1,SOCS2,HKDC1,PKM,MAPK3,SOCS3,PRKCE,IRS2,INSR,SOCS1,MAPK9,PIK3R2,IKBKB,PRKCZ,PIK3R3,KCNJ11,HK1,HK3,MAPK1
ko04130	SNARE interactions in vesicular transport	0.0794746479516445	-2.53231720186926	34	17	0.00668501769563508	2543	6908	55850,8674,9482,8673,9341,143187,55014,10282,10652,6810,9527,8675,8773,9342,9554,51272,6811	USE1,VAMP4,STX8,VAMP8,VAMP3,VTI1A,STX17,BET1,YKT6,STX4,GOSR1,STX16,SNAP23,SNAP29,SEC22B,BET1L,STX5
hsa04130	SNARE interactions in vesicular transport	0.0794746479516445	-2.53231720186926	34	17	0.00668501769563508	2543	6908	55850,8674,9482,8673,9341,143187,55014,10282,10652,6810,9527,8675,8773,9342,9554,51272,6811	USE1,VAMP4,STX8,VAMP8,VAMP3,VTI1A,STX17,BET1,YKT6,STX4,GOSR1,STX16,SNAP23,SNAP29,SEC22B,BET1L,STX5
hsa00511	Other glycan degradation	0.0818475022189212	-2.50289749219849	18	10	0.00393236335037357	2543	6908	2517,23324,57704,10825,2629,284004,2720,4125,3073,175	FUCA1,MAN2B2,GBA2,NEU3,GBA,HEXDC,GLB1,MAN2B1,HEXA,AGA
ko00511	Other glycan degradation	0.0818475022189212	-2.50289749219849	18	10	0.00393236335037357	2543	6908	2517,23324,57704,10825,2629,284004,2720,4125,3073,175	FUCA1,MAN2B2,GBA2,NEU3,GBA,HEXDC,GLB1,MAN2B1,HEXA,AGA
hsa00564	Glycerophospholipid metabolism	0.0820936416838987	-2.49989471151678	95	42	0.016515926071569	2543	6908	8760,84803,55500,10554,162466,8527,10162,56894,81579,64900,10423,11145,253558,1119,2819,8611,55326,10434,81490,5833,79888,23171,8398,11313,85465,56895,8612,6901,79143,137964,3931,10400,8443,23659,254531,10908,154141,5337,57678,129642,9791,5130	CDS2,GPAT3,ETNK1,AGPAT1,PHOSPHO1,DGKD,LPCAT3,AGPAT3,PLA2G12A,LPIN3,CDIPT,PLA2G16,LCLAT1,CHKA,GPD1,PLPP1,AGPAT5,LYPLA1,PTDSS2,PCYT2,LPCAT1,GPD1L,PLA2G6,LYPLA2,EPT1,AGPAT4,PLPP2,TAZ,MBOAT7,GPAT4,LCAT,PEMT,GNPAT,PLA2G15,LPCAT4,PNPLA6,MBOAT1,PLD1,GPAM,MBOAT2,PTDSS1,PCYT1A
ko00564	Glycerophospholipid metabolism	0.0820936416838987	-2.49989471151678	95	42	0.016515926071569	2543	6908	8760,84803,55500,10554,162466,56894,8527,10162,81579,64900,11145,10423,253558,1119,2819,8611,55326,10434,81490,5833,23171,79888,8398,11313,85465,56895,8612,6901,79143,137964,3931,10400,23659,8443,254531,10908,154141,57678,5337,129642,9791,5130	CDS2,GPAT3,ETNK1,AGPAT1,PHOSPHO1,AGPAT3,DGKD,LPCAT3,PLA2G12A,LPIN3,PLA2G16,CDIPT,LCLAT1,CHKA,GPD1,PLPP1,AGPAT5,LYPLA1,PTDSS2,PCYT2,GPD1L,LPCAT1,PLA2G6,LYPLA2,EPT1,AGPAT4,PLPP2,TAZ,MBOAT7,GPAT4,LCAT,PEMT,PLA2G15,GNPAT,LPCAT4,PNPLA6,MBOAT1,GPAM,PLD1,MBOAT2,PTDSS1,PCYT1A
hsa00480	Glutathione metabolism	0.0855997988248774	-2.45807234601387	51	24	0.00943767204089658	2543	6908	6723,26873,2729,2948,4259,6240,6241,2952,3418,4258,3417,4953,4257,493869,5226,2937,373156,79017,119391,50484,2539,51060,2876,2879	SRM,OPLAH,GCLC,GSTM4,MGST3,RRM1,RRM2,GSTT1,IDH2,MGST2,IDH1,ODC1,MGST1,GPX8,PGD,GSS,GSTK1,GGCT,GSTO2,RRM2B,G6PD,TXNDC12,GPX1,GPX4
ko00480	Glutathione metabolism	0.0855997988248774	-2.45807234601387	51	24	0.00943767204089658	2543	6908	6723,26873,2729,2948,4259,6240,2952,6241,3418,4258,4953,3417,4257,493869,2937,5226,373156,79017,119391,50484,2539,51060,2876,2879	SRM,OPLAH,GCLC,GSTM4,MGST3,RRM1,GSTT1,RRM2,IDH2,MGST2,ODC1,IDH1,MGST1,GPX8,GSS,PGD,GSTK1,GGCT,GSTO2,RRM2B,G6PD,TXNDC12,GPX1,GPX4
hsa00970	Aminoacyl-tRNA biosynthesis	0.0900110282445652	-2.40782308010808	44	21	0.00825796303578451	2543	6908	833,3735,5188,2617,124454,23395,57505,10667,7407,80222,16,51067,2193,5917,92935,3376,123263,55157,23438,51091,79587	CARS,KARS,GATB,GARS,EARS2,LARS2,AARS2,FARS2,VARS,TARS2,AARS,YARS2,FARSA,RARS,MARS2,IARS,MTFMT,DARS2,HARS2,SEPSECS,CARS2
ko00970	Aminoacyl-tRNA biosynthesis	0.0900110282445652	-2.40782308010808	44	21	0.00825796303578451	2543	6908	833,3735,5188,2617,124454,23395,57505,10667,7407,16,80222,51067,5917,2193,92935,123263,3376,55157,23438,51091,79587	CARS,KARS,GATB,GARS,EARS2,LARS2,AARS2,FARS2,VARS,AARS,TARS2,YARS2,RARS,FARSA,MARS2,MTFMT,IARS,DARS2,HARS2,SEPSECS,CARS2
hsa05222	Small cell lung cancer	0.0953625664315267	-2.35006916294496	86	38	0.0149429807314196	2543	6908	1030,7186,6256,1147,598,329,898,3551,5296,1163,8503,3913,1027,2272,5970,1021,1164,5915,3915,330,207,208,842,5295,6502,1871,5747,6257,5743,7185,3673,9063,3688,3685,317,1870,9618,1288	CDKN2B,TRAF2,RXRA,CHUK,BCL2L1,BIRC2,CCNE1,IKBKB,PIK3R2,CKS1B,PIK3R3,LAMB2,CDKN1B,FHIT,RELA,CDK6,CKS2,RARB,LAMC1,BIRC3,AKT1,AKT2,CASP9,PIK3R1,SKP2,E2F3,PTK2,RXRB,PTGS2,TRAF1,ITGA2,PIAS2,ITGB1,ITGAV,APAF1,E2F2,TRAF4,COL4A6
ko05222	Small cell lung cancer	0.0953625664315267	-2.35006916294496	86	38	0.0149429807314196	2543	6908	1030,7186,6256,1147,598,329,898,3551,5296,1163,8503,3913,1027,2272,5970,1021,1164,5915,3915,330,207,208,842,5295,6502,1871,5747,6257,5743,7185,3673,9063,3688,3685,317,1870,9618,1288	CDKN2B,TRAF2,RXRA,CHUK,BCL2L1,BIRC2,CCNE1,IKBKB,PIK3R2,CKS1B,PIK3R3,LAMB2,CDKN1B,FHIT,RELA,CDK6,CKS2,RARB,LAMC1,BIRC3,AKT1,AKT2,CASP9,PIK3R1,SKP2,E2F3,PTK2,RXRB,PTGS2,TRAF1,ITGA2,PIAS2,ITGB1,ITGAV,APAF1,E2F2,TRAF4,COL4A6
ko05231	Choline metabolism in cancer	0.0954305717759321	-2.34935629299666	101	44	0.0173023987416437	2543	6908	10163,5599,8936,7249,2475,5894,5879,5604,5900,8527,5881,1119,8611,5296,5601,23446,10434,57153,8503,6584,6199,6667,5170,6655,207,6654,208,5295,8612,8394,5605,6009,5595,2885,5335,3091,8976,1978,6198,5337,5594,6583,3265,5130	WASF2,MAPK8,WASF1,TSC2,MTOR,RAF1,RAC1,MAP2K1,RALGDS,DGKD,RAC3,CHKA,PLPP1,PIK3R2,MAPK9,SLC44A1,LYPLA1,SLC44A2,PIK3R3,SLC22A5,RPS6KB2,SP1,PDPK1,SOS2,AKT1,SOS1,AKT2,PIK3R1,PLPP2,PIP5K1A,MAP2K2,RHEB,MAPK3,GRB2,PLCG1,HIF1A,WASL,EIF4EBP1,RPS6KB1,PLD1,MAPK1,SLC22A4,HRAS,PCYT1A
hsa05231	Choline metabolism in cancer	0.0954305717759321	-2.34935629299666	101	44	0.0173023987416437	2543	6908	10163,5599,8936,7249,2475,5894,5879,5604,5900,8527,5881,1119,8611,5296,5601,23446,10434,57153,8503,6584,6199,6667,5170,6655,207,6654,208,5295,8612,8394,5605,6009,5595,2885,5335,3091,8976,1978,6198,5337,5594,6583,3265,5130	WASF2,MAPK8,WASF1,TSC2,MTOR,RAF1,RAC1,MAP2K1,RALGDS,DGKD,RAC3,CHKA,PLPP1,PIK3R2,MAPK9,SLC44A1,LYPLA1,SLC44A2,PIK3R3,SLC22A5,RPS6KB2,SP1,PDPK1,SOS2,AKT1,SOS1,AKT2,PIK3R1,PLPP2,PIP5K1A,MAP2K2,RHEB,MAPK3,GRB2,PLCG1,HIF1A,WASL,EIF4EBP1,RPS6KB1,PLD1,MAPK1,SLC22A4,HRAS,PCYT1A
ko00052	Galactose metabolism	0.096345764500009	-2.33981184461049	30	15	0.00589854502556036	2543	6908	5236,55276,7360,5211,231,2720,80201,3098,2595,2717,92579,3101,8704,5214,2582	PGM1,PGM2,UGP2,PFKL,AKR1B1,GLB1,HKDC1,HK1,GANC,GLA,G6PC3,HK3,B4GALT2,PFKP,GALE
hsa00052	Galactose metabolism	0.096345764500009	-2.33981184461049	30	15	0.00589854502556036	2543	6908	5236,55276,7360,5211,231,2720,80201,3098,2595,2717,92579,3101,8704,5214,2582	PGM1,PGM2,UGP2,PFKL,AKR1B1,GLB1,HKDC1,HK1,GANC,GLA,G6PC3,HK3,B4GALT2,PFKP,GALE
hsa04010	MAPK signaling pathway	0.101882401566385	-2.28393605664787	255	104	0.0408965788438852	2543	6908	5599,836,5607,4763,5894,5879,5604,59285,51701,22808,1147,785,5495,5566,3303,5881,5606,3727,1399,5906,6196,3551,8986,5494,4791,1386,5970,5567,4215,6655,468,207,208,2257,8550,1846,9064,2260,3305,1398,1616,23118,80824,4616,4296,6722,5533,784,5536,5594,10454,409,4137,1844,9344,673,9175,7186,10912,8649,23162,5532,9252,1847,2122,59283,6788,783,5062,5601,2872,5598,9020,22800,1843,51347,4214,5871,6237,5609,7867,8913,6654,3164,51295,5908,100506012,5605,5921,3304,5595,2885,2768,1647,1845,5608,5534,4217,3265,6416,781,6197,1649,6789	MAPK8,CASP3,MAP2K5,NF1,RAF1,RAC1,MAP2K1,CACNG6,NLK,MRAS,CHUK,CACNB4,PPM1B,PRKACA,HSPA1A,RAC3,MAP2K3,JUND,CRKL,RAP1A,RPS6KA2,IKBKB,RPS6KA4,PPM1A,NFKB2,ATF2,RELA,PRKACB,MAP3K3,SOS2,ATF4,AKT1,AKT2,FGF12,MAPKAPK5,DUSP4,MAP3K6,FGFR1,HSPA1L,CRK,DAXX,TAB2,DUSP16,GADD45B,MAP3K11,SRF,PPP3CC,CACNB3,PPP5C,MAPK1,TAB1,ARRB2,MAPT,DUSP2,TAOK2,BRAF,MAP3K13,TRAF2,GADD45G,LAMTOR3,MAPK8IP3,PPP3CB,RPS6KA5,DUSP5,MECOM,CACNG8,STK3,CACNB2,PAK2,MAPK9,MKNK2,MAPK7,MAP3K14,RRAS2,DUSP1,TAOK3,MAP3K1,MAP4K2,RRAS,MAP2K7,MAPKAPK3,CACNA1G,SOS1,NR4A1,ECSIT,RAP1B,PPP5D1,MAP2K2,RASA1,HSPA1B,MAPK3,GRB2,GNA12,GADD45A,DUSP3,MAP2K6,PPP3R1,MAP3K5,HRAS,MAP2K4,CACNA2D1,RPS6KA3,DDIT3,STK4
ko04010	MAPK signaling pathway	0.101882401566385	-2.28393605664787	255	104	0.0408965788438852	2543	6908	5599,836,5607,4763,5894,5879,5604,59285,51701,1147,22808,5495,5566,785,3303,5881,5606,3727,1399,6196,5906,3551,8986,5494,4791,1386,5970,5567,4215,6655,468,207,208,2257,8550,1846,9064,2260,3305,1398,1616,23118,80824,4616,4296,6722,5533,784,5536,5594,10454,409,4137,1844,673,9344,9175,7186,10912,23162,8649,5532,9252,1847,2122,59283,6788,783,5601,5062,2872,9020,5598,22800,1843,4214,51347,5871,5609,6237,6654,8913,7867,3164,100506012,51295,5908,5605,5921,3304,5595,2885,2768,1647,1845,5608,5534,4217,3265,6416,781,1649,6197,6789	MAPK8,CASP3,MAP2K5,NF1,RAF1,RAC1,MAP2K1,CACNG6,NLK,CHUK,MRAS,PPM1B,PRKACA,CACNB4,HSPA1A,RAC3,MAP2K3,JUND,CRKL,RPS6KA2,RAP1A,IKBKB,RPS6KA4,PPM1A,NFKB2,ATF2,RELA,PRKACB,MAP3K3,SOS2,ATF4,AKT1,AKT2,FGF12,MAPKAPK5,DUSP4,MAP3K6,FGFR1,HSPA1L,CRK,DAXX,TAB2,DUSP16,GADD45B,MAP3K11,SRF,PPP3CC,CACNB3,PPP5C,MAPK1,TAB1,ARRB2,MAPT,DUSP2,BRAF,TAOK2,MAP3K13,TRAF2,GADD45G,MAPK8IP3,LAMTOR3,PPP3CB,RPS6KA5,DUSP5,MECOM,CACNG8,STK3,CACNB2,MAPK9,PAK2,MKNK2,MAP3K14,MAPK7,RRAS2,DUSP1,MAP3K1,TAOK3,MAP4K2,MAP2K7,RRAS,SOS1,CACNA1G,MAPKAPK3,NR4A1,PPP5D1,ECSIT,RAP1B,MAP2K2,RASA1,HSPA1B,MAPK3,GRB2,GNA12,GADD45A,DUSP3,MAP2K6,PPP3R1,MAP3K5,HRAS,MAP2K4,CACNA2D1,DDIT3,RPS6KA3,STK4
hsa05213	Endometrial cancer	0.105286010556821	-2.25107472187956	52	24	0.00943767204089658	2543	6908	5170,6655,673,207,6654,1495,5894,208,5295,842,5604,2064,324,5605,2309,6934,5595,2885,1499,5296,8503,2932,5594,3265	PDPK1,SOS2,BRAF,AKT1,SOS1,CTNNA1,RAF1,AKT2,PIK3R1,CASP9,MAP2K1,ERBB2,APC,MAP2K2,FOXO3,TCF7L2,MAPK3,GRB2,CTNNB1,PIK3R2,PIK3R3,GSK3B,MAPK1,HRAS
ko05213	Endometrial cancer	0.105286010556821	-2.25107472187956	52	24	0.00943767204089658	2543	6908	5170,6655,673,207,6654,1495,5894,208,5295,842,5604,2064,324,5605,2309,6934,5595,2885,1499,5296,8503,2932,5594,3265	PDPK1,SOS2,BRAF,AKT1,SOS1,CTNNA1,RAF1,AKT2,PIK3R1,CASP9,MAP2K1,ERBB2,APC,MAP2K2,FOXO3,TCF7L2,MAPK3,GRB2,CTNNB1,PIK3R2,PIK3R3,GSK3B,MAPK1,HRAS
hsa04917	Prolactin signaling pathway	0.110731442205848	-2.20064744883018	72	32	0.0125835627211954	2543	6908	5599,6655,207,6654,208,5894,8835,5295,5604,6777,2100,2309,5605,5595,30837,9021,2885,1154,6464,8651,5296,5601,2932,8503,3717,6776,5970,5594,6774,3265,3659,9655	MAPK8,SOS2,AKT1,SOS1,AKT2,RAF1,SOCS2,PIK3R1,MAP2K1,STAT5B,ESR2,FOXO3,MAP2K2,MAPK3,SOCS7,SOCS3,GRB2,CISH,SHC1,SOCS1,PIK3R2,MAPK9,GSK3B,PIK3R3,JAK2,STAT5A,RELA,MAPK1,STAT3,HRAS,IRF1,SOCS5
ko04917	Prolactin signaling pathway	0.110731442205848	-2.20064744883018	72	32	0.0125835627211954	2543	6908	5599,6655,207,6654,208,5894,8835,5295,5604,6777,2100,2309,5605,5595,30837,9021,2885,1154,6464,8651,5296,5601,2932,8503,3717,6776,5970,5594,6774,3265,3659,9655	MAPK8,SOS2,AKT1,SOS1,AKT2,RAF1,SOCS2,PIK3R1,MAP2K1,STAT5B,ESR2,FOXO3,MAP2K2,MAPK3,SOCS7,SOCS3,GRB2,CISH,SHC1,SOCS1,PIK3R2,MAPK9,GSK3B,PIK3R3,JAK2,STAT5A,RELA,MAPK1,STAT3,HRAS,IRF1,SOCS5
ko04668	TNF signaling pathway	0.116260917483371	-2.15191832508885	110	47	0.0184821077467558	2543	6908	5599,836,1388,257397,2921,7186,5604,1147,2920,10488,9252,8809,329,5606,182,3551,5296,5601,3726,8503,8986,602,9020,841,1386,5970,468,5609,330,207,7128,208,83737,5295,5595,9021,5743,840,7185,23118,5608,3569,192111,4217,10454,5594,6416	MAPK8,CASP3,ATF6B,TAB3,CXCL3,TRAF2,MAP2K1,CHUK,CXCL2,CREB3,RPS6KA5,IL18R1,BIRC2,MAP2K3,JAG1,IKBKB,PIK3R2,MAPK9,JUNB,PIK3R3,RPS6KA4,BCL3,MAP3K14,CASP8,ATF2,RELA,ATF4,MAP2K7,BIRC3,AKT1,TNFAIP3,AKT2,ITCH,PIK3R1,MAPK3,SOCS3,PTGS2,CASP7,TRAF1,TAB2,MAP2K6,IL6,PGAM5,MAP3K5,TAB1,MAPK1,MAP2K4
hsa04668	TNF signaling pathway	0.116260917483371	-2.15191832508885	110	47	0.0184821077467558	2543	6908	5599,836,1388,257397,2921,7186,5604,1147,2920,10488,9252,8809,329,5606,182,3551,5296,5601,3726,8503,8986,602,9020,841,1386,5970,468,5609,330,207,7128,208,83737,5295,5595,9021,5743,840,7185,23118,5608,3569,192111,4217,10454,5594,6416	MAPK8,CASP3,ATF6B,TAB3,CXCL3,TRAF2,MAP2K1,CHUK,CXCL2,CREB3,RPS6KA5,IL18R1,BIRC2,MAP2K3,JAG1,IKBKB,PIK3R2,MAPK9,JUNB,PIK3R3,RPS6KA4,BCL3,MAP3K14,CASP8,ATF2,RELA,ATF4,MAP2K7,BIRC3,AKT1,TNFAIP3,AKT2,ITCH,PIK3R1,MAPK3,SOCS3,PTGS2,CASP7,TRAF1,TAB2,MAP2K6,IL6,PGAM5,MAP3K5,TAB1,MAPK1,MAP2K4
ko05034	Alcoholism	0.116662244435673	-2.14847231872228	179	74	0.0290994887927645	2543	6908	3015,2785,84254,5894,5604,2782,85235,8350,8358,2030,10013,5566,2783,440689,8365,6464,8366,8364,2354,5499,1386,8331,8352,6655,468,94239,2773,10014,2770,8294,9759,8351,59345,3014,5500,3065,3020,8338,5594,3066,673,1388,8367,814,808,83933,10488,8969,5501,8360,121504,10681,51564,9555,653604,8345,8520,2771,92815,8968,8336,6654,8841,8368,8357,5595,2885,2778,8330,3012,8334,3265,5569,8354	H2AFZ,GNG3,CAMKK1,RAF1,MAP2K1,GNB1,HIST1H2AH,HIST1H3A,HIST1H3B,SLC29A1,HDAC6,PRKACA,GNB2,HIST2H2BF,HIST1H4H,SHC1,HIST1H4B,HIST1H4C,FOSB,PPP1CA,ATF2,HIST1H2AJ,HIST1H3C,SOS2,ATF4,H2AFV,GNAI3,HDAC5,GNAI1,HIST1H4I,HDAC4,HIST1H3D,GNB4,H2AFX,PPP1CB,HDAC1,H3F3A,HIST2H2AC,MAPK1,HDAC2,BRAF,ATF6B,HIST1H4E,CAMK4,CALM3,HDAC10,CREB3,HIST1H2AG,PPP1CC,HIST1H4D,HIST4H4,GNB5,HDAC7,H2AFY,HIST2H3D,HIST1H2BH,HAT1,GNAI2,HIST3H2A,HIST1H3F,HIST1H2AM,SOS1,HDAC3,HIST1H4L,HIST1H3H,MAPK3,GRB2,GNAS,HIST1H2AK,HIST1H2AE,HIST1H2AC,HRAS,PKIA,HIST1H3I
hsa05034	Alcoholism	0.116662244435673	-2.14847231872228	179	74	0.0290994887927645	2543	6908	3015,2785,84254,5894,5604,2782,85235,8350,8358,2030,10013,5566,2783,440689,8365,6464,8366,8364,2354,5499,1386,8331,8352,6655,468,94239,2773,10014,2770,8294,9759,8351,59345,3014,5500,3065,3020,8338,5594,3066,673,1388,8367,814,808,83933,10488,8969,5501,8360,121504,10681,51564,9555,653604,8345,8520,2771,92815,8968,8336,6654,8841,8368,8357,5595,2885,2778,8330,3012,8334,3265,5569,8354	H2AFZ,GNG3,CAMKK1,RAF1,MAP2K1,GNB1,HIST1H2AH,HIST1H3A,HIST1H3B,SLC29A1,HDAC6,PRKACA,GNB2,HIST2H2BF,HIST1H4H,SHC1,HIST1H4B,HIST1H4C,FOSB,PPP1CA,ATF2,HIST1H2AJ,HIST1H3C,SOS2,ATF4,H2AFV,GNAI3,HDAC5,GNAI1,HIST1H4I,HDAC4,HIST1H3D,GNB4,H2AFX,PPP1CB,HDAC1,H3F3A,HIST2H2AC,MAPK1,HDAC2,BRAF,ATF6B,HIST1H4E,CAMK4,CALM3,HDAC10,CREB3,HIST1H2AG,PPP1CC,HIST1H4D,HIST4H4,GNB5,HDAC7,H2AFY,HIST2H3D,HIST1H2BH,HAT1,GNAI2,HIST3H2A,HIST1H3F,HIST1H2AM,SOS1,HDAC3,HIST1H4L,HIST1H3H,MAPK3,GRB2,GNAS,HIST1H2AK,HIST1H2AE,HIST1H2AC,HRAS,PKIA,HIST1H3I
hsa04122	Sulfur relay system	0.117771796048879	-2.13900645876624	10	6	0.00235941801022414	2543	6908	348180,90353,9054,4357,81605,7263	CTU2,CTU1,NFS1,MPST,URM1,TST
ko00920	Sulfur metabolism	0.117771796048879	-2.13900645876624	10	6	0.00235941801022414	2543	6908	58472,6821,54928,4357,9061,7263	SQRDL,SUOX,IMPAD1,MPST,PAPSS1,TST
ko04122	Sulfur relay system	0.117771796048879	-2.13900645876624	10	6	0.00235941801022414	2543	6908	348180,90353,9054,4357,81605,7263	CTU2,CTU1,NFS1,MPST,URM1,TST
hsa00920	Sulfur metabolism	0.117771796048879	-2.13900645876624	10	6	0.00235941801022414	2543	6908	58472,6821,54928,4357,9061,7263	SQRDL,SUOX,IMPAD1,MPST,PAPSS1,TST
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	0.129970109890986	-2.0404507788786	68	30	0.0117970900511207	2543	6908	5599,836,6868,523,102,5879,537,535,50848,1147,7082,4067,5335,51382,10312,10392,3551,5601,5781,23545,527,528,51606,9020,529,5970,9114,8992,6416,9550	MAPK8,CASP3,ADAM17,ATP6V1A,ADAM10,RAC1,ATP6AP1,ATP6V0A1,F11R,CHUK,TJP1,LYN,PLCG1,ATP6V1D,TCIRG1,NOD1,IKBKB,MAPK9,PTPN11,ATP6V0A2,ATP6V0C,ATP6V1C1,ATP6V1H,MAP3K14,ATP6V1E1,RELA,ATP6V0D1,ATP6V0E1,MAP2K4,ATP6V1G1
ko05120	Epithelial cell signaling in Helicobacter pylori infection	0.129970109890986	-2.0404507788786	68	30	0.0117970900511207	2543	6908	5599,836,6868,523,102,5879,537,535,50848,1147,7082,4067,5335,51382,10312,10392,3551,5601,5781,23545,527,528,51606,9020,529,5970,9114,8992,6416,9550	MAPK8,CASP3,ADAM17,ATP6V1A,ADAM10,RAC1,ATP6AP1,ATP6V0A1,F11R,CHUK,TJP1,LYN,PLCG1,ATP6V1D,TCIRG1,NOD1,IKBKB,MAPK9,PTPN11,ATP6V0A2,ATP6V0C,ATP6V1C1,ATP6V1H,MAP3K14,ATP6V1E1,RELA,ATP6V0D1,ATP6V0E1,MAP2K4,ATP6V1G1
ko05219	Bladder cancer	0.134751725518718	-2.00432126394131	41	19	0.00747149036570979	2543	6908	673,5894,5604,1871,11186,2064,1026,7422,9252,5605,1613,5595,7057,1890,4193,1870,5594,3265,1029	BRAF,RAF1,MAP2K1,E2F3,RASSF1,ERBB2,CDKN1A,VEGFA,RPS6KA5,MAP2K2,DAPK3,MAPK3,THBS1,TYMP,MDM2,E2F2,MAPK1,HRAS,CDKN2A
hsa05219	Bladder cancer	0.134751725518718	-2.00432126394131	41	19	0.00747149036570979	2543	6908	673,5894,5604,1871,11186,2064,1026,7422,9252,5605,1613,5595,7057,1890,4193,1870,5594,3265,1029	BRAF,RAF1,MAP2K1,E2F3,RASSF1,ERBB2,CDKN1A,VEGFA,RPS6KA5,MAP2K2,DAPK3,MAPK3,THBS1,TYMP,MDM2,E2F2,MAPK1,HRAS,CDKN2A
ko04922	Glucagon signaling pathway	0.13480050598156	-2.00395932693857	101	43	0.0169091624066064	2543	6908	2033,5837,5565,5562,3276,808,1375,5532,10488,3709,5566,1387,5255,5211,57223,5256,5106,150094,1386,5261,5567,31,3945,23411,5160,468,207,208,5531,5465,5571,5315,3710,92579,2778,817,51422,3708,5534,5224,5533,10891,5223	EP300,PYGM,PRKAB2,PRKAA1,PRMT1,CALM3,CPT1B,PPP3CB,CREB3,ITPR2,PRKACA,CREBBP,PHKA1,PFKL,PPP4R3B,PHKA2,PCK2,SIK1,ATF2,PHKG2,PRKACB,ACACA,LDHB,SIRT1,PDHA1,ATF4,AKT1,AKT2,PPP4C,PPARA,PRKAG1,PKM,ITPR3,G6PC3,GNAS,CAMK2D,PRKAG2,ITPR1,PPP3R1,PGAM2,PPP3CC,PPARGC1A,PGAM1
hsa04922	Glucagon signaling pathway	0.13480050598156	-2.00395932693857	101	43	0.0169091624066064	2543	6908	2033,5837,5565,5562,3276,808,1375,5532,10488,3709,5566,1387,5255,5211,57223,5256,5106,150094,1386,5261,5567,31,3945,23411,5160,468,207,208,5531,5465,5571,5315,3710,92579,2778,817,51422,3708,5534,5224,5533,10891,5223	EP300,PYGM,PRKAB2,PRKAA1,PRMT1,CALM3,CPT1B,PPP3CB,CREB3,ITPR2,PRKACA,CREBBP,PHKA1,PFKL,PPP4R3B,PHKA2,PCK2,SIK1,ATF2,PHKG2,PRKACB,ACACA,LDHB,SIRT1,PDHA1,ATF4,AKT1,AKT2,PPP4C,PPARA,PRKAG1,PKM,ITPR3,G6PC3,GNAS,CAMK2D,PRKAG2,ITPR1,PPP3R1,PGAM2,PPP3CC,PPARGC1A,PGAM1
hsa00750	Vitamin B6 metabolism	0.138003032265594	-1.98047962112725	6	4	0.00157294534014943	2543	6908	55163,8566,29968,493911	PNPO,PDXK,PSAT1,PHOSPHO2
ko00750	Vitamin B6 metabolism	0.138003032265594	-1.98047962112725	6	4	0.00157294534014943	2543	6908	55163,8566,29968,493911	PNPO,PDXK,PSAT1,PHOSPHO2
hsa03440	Homologous recombination	0.1383722069498	-1.97780807280168	29	14	0.005505308690523	2543	6908	5889,80198,5888,7979,7516,4361,7517,6742,8438,641,10714,5424,5425,25788	RAD51C,MUS81,RAD51,SHFM1,XRCC2,MRE11A,XRCC3,SSBP1,RAD54L,BLM,POLD3,POLD1,POLD2,RAD54B
ko03440	Homologous recombination	0.1383722069498	-1.97780807280168	29	14	0.005505308690523	2543	6908	5889,5888,80198,7979,7516,4361,7517,8438,6742,641,10714,5424,5425,25788	RAD51C,RAD51,MUS81,SHFM1,XRCC2,MRE11A,XRCC3,RAD54L,SSBP1,BLM,POLD3,POLD1,POLD2,RAD54B
hsa04360	Axon guidance	0.143081728049155	-1.94433928716107	127	53	0.0208415257569799	2543	6908	5879,6091,4917,8482,5532,1947,10298,5881,5364,27289,25,3983,10505,1808,5998,5062,57522,2050,56920,2771,9353,9475,10500,3985,2242,7869,2049,387,4690,23365,5747,2773,1073,5921,84448,5595,2770,7852,2534,1969,1945,3984,3688,5534,2932,5533,10512,4776,6093,8829,5594,3265,10509	RAC1,ROBO1,NTN3,SEMA7A,PPP3CB,EFNB1,PAK4,RAC3,PLXNB1,RND1,ABL1,ABLIM1,SEMA4F,DPYSL2,RGS3,PAK2,SRGAP1,EPHB4,SEMA3G,GNAI2,SLIT2,ROCK2,SEMA6C,LIMK2,FES,SEMA3B,EPHB3,RHOA,NCK1,ARHGEF12,PTK2,GNAI3,CFL2,RASA1,ABLIM2,MAPK3,GNAI1,CXCR4,FYN,EPHA2,EFNA4,LIMK1,ITGB1,PPP3R1,GSK3B,PPP3CC,SEMA3C,NFATC4,ROCK1,NRP1,MAPK1,HRAS,SEMA4B
ko04360	Axon guidance	0.143081728049155	-1.94433928716107	127	53	0.0208415257569799	2543	6908	5879,6091,4917,8482,5532,1947,10298,5881,5364,27289,25,3983,10505,1808,5998,5062,57522,2050,56920,2771,9353,9475,10500,3985,2242,7869,2049,387,4690,23365,5747,2773,1073,5921,84448,5595,2770,7852,2534,1969,1945,3984,3688,5534,2932,5533,10512,4776,6093,8829,5594,3265,10509	RAC1,ROBO1,NTN3,SEMA7A,PPP3CB,EFNB1,PAK4,RAC3,PLXNB1,RND1,ABL1,ABLIM1,SEMA4F,DPYSL2,RGS3,PAK2,SRGAP1,EPHB4,SEMA3G,GNAI2,SLIT2,ROCK2,SEMA6C,LIMK2,FES,SEMA3B,EPHB3,RHOA,NCK1,ARHGEF12,PTK2,GNAI3,CFL2,RASA1,ABLIM2,MAPK3,GNAI1,CXCR4,FYN,EPHA2,EFNA4,LIMK1,ITGB1,PPP3R1,GSK3B,PPP3CC,SEMA3C,NFATC4,ROCK1,NRP1,MAPK1,HRAS,SEMA4B
hsa00730	Thiamine metabolism	0.144385813888067	-1.93526629912184	4	3	0.00117970900511207	2543	6908	84284,9054,27010	NTPCR,NFS1,TPK1
ko00730	Thiamine metabolism	0.144385813888067	-1.93526629912184	4	3	0.00117970900511207	2543	6908	84284,9054,27010	NTPCR,NFS1,TPK1
ko00071	Fatty acid degradation	0.150318752093975	-1.89499722557467	44	20	0.00786472670074715	2543	6908	2180,1962,2181,1892,1375,2639,30,1632,128,39,36,51,10449,3032,38,10455,2182,8310,224,223	ACSL1,EHHADH,ACSL3,ECHS1,CPT1B,GCDH,ACAA1,ECI1,ADH5,ACAT2,ACADSB,ACOX1,ACAA2,HADHB,ACAT1,ECI2,ACSL4,ACOX3,ALDH3A2,ALDH9A1
hsa00071	Fatty acid degradation	0.150318752093975	-1.89499722557467	44	20	0.00786472670074715	2543	6908	2180,1962,2181,1892,1375,2639,30,1632,128,39,36,51,10449,3032,38,10455,2182,8310,224,223	ACSL1,EHHADH,ACSL3,ECHS1,CPT1B,GCDH,ACAA1,ECI1,ADH5,ACAT2,ACADSB,ACOX1,ACAA2,HADHB,ACAT1,ECI2,ACSL4,ACOX3,ALDH3A2,ALDH9A1
ko00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0.160302656054237	-1.8306916502323	20	10	0.00393236335037357	2543	6908	50515,55501,51363,64132,9469,113189,22856,54480,11285,55454	CHST11,CHST12,CHST15,XYLT2,CHST3,CHST14,CHSY1,CHPF2,B4GALT7,CSGALNACT2
hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0.160302656054237	-1.8306916502323	20	10	0.00393236335037357	2543	6908	50515,55501,51363,64132,9469,113189,22856,54480,55454,11285	CHST11,CHST12,CHST15,XYLT2,CHST3,CHST14,CHSY1,CHPF2,CSGALNACT2,B4GALT7
hsa03450	Non-homologous end-joining	0.161589868752378	-1.82269382822445	13	7	0.0027526543452615	2543	6908	3981,4361,5591,79840,27434,7520,27343	LIG4,MRE11A,PRKDC,NHEJ1,POLM,XRCC5,POLL
ko03450	Non-homologous end-joining	0.161589868752378	-1.82269382822445	13	7	0.0027526543452615	2543	6908	3981,4361,79840,5591,27434,7520,27343	LIG4,MRE11A,NHEJ1,PRKDC,POLM,XRCC5,POLL
hsa00270	Cysteine and methionine metabolism	0.162349440458436	-1.81800422695332	37	17	0.00668501769563508	2543	6908	6723,58478,113675,4191,262,84245,23382,4507,4144,7263,2806,4190,51074,10768,4357,3945,1491	SRM,ENOPH1,SDSL,MDH2,AMD1,MRI1,AHCYL2,MTAP,MAT2A,TST,GOT2,MDH1,APIP,AHCYL1,MPST,LDHB,CTH
ko00270	Cysteine and methionine metabolism	0.162349440458436	-1.81800422695332	37	17	0.00668501769563508	2543	6908	6723,58478,113675,4191,262,84245,23382,4507,4144,7263,2806,4190,51074,10768,4357,3945,1491	SRM,ENOPH1,SDSL,MDH2,AMD1,MRI1,AHCYL2,MTAP,MAT2A,TST,GOT2,MDH1,APIP,AHCYL1,MPST,LDHB,CTH
ko05132	Salmonella infection	0.170167444438571	-1.77097235940815	85	36	0.0141565080613449	2543	6908	10163,5599,391,1781,81873,8936,71,2921,5879,89953,3831,3606,7082,10093,2920,4628,5217,5586,10092,5601,79659,3459,5970,9475,83547,7879,10552,5595,29941,8976,3569,60,6093,10109,5594,1783	WASF2,MAPK8,RHOG,DYNC1I2,ARPC5L,WASF1,ACTG1,CXCL3,RAC1,KLC4,KLC1,IL18,TJP1,ARPC4,CXCL2,MYH10,PFN2,PKN2,ARPC5,MAPK9,DYNC2H1,IFNGR1,RELA,ROCK2,RILP,RAB7A,ARPC1A,MAPK3,PKN3,WASL,IL6,ACTB,ROCK1,ARPC2,MAPK1,DYNC1LI2
hsa05132	Salmonella infection	0.170167444438571	-1.77097235940815	85	36	0.0141565080613449	2543	6908	10163,5599,391,1781,81873,8936,71,2921,5879,89953,3831,3606,7082,10093,2920,4628,5217,5586,10092,5601,79659,3459,5970,9475,83547,7879,10552,5595,29941,8976,3569,60,6093,10109,5594,1783	WASF2,MAPK8,RHOG,DYNC1I2,ARPC5L,WASF1,ACTG1,CXCL3,RAC1,KLC4,KLC1,IL18,TJP1,ARPC4,CXCL2,MYH10,PFN2,PKN2,ARPC5,MAPK9,DYNC2H1,IFNGR1,RELA,ROCK2,RILP,RAB7A,ARPC1A,MAPK3,PKN3,WASL,IL6,ACTB,ROCK1,ARPC2,MAPK1,DYNC1LI2
hsa00250	Alanine, aspartate and glutamate metabolism	0.178430312830283	-1.72355715830219	35	16	0.00629178136059772	2543	6908	84706,2673,9945,1373,5471,435,158,56954,122622,2752,2744,8659,57494,440,2806,2571	GPT2,GFPT1,GFPT2,CPS1,PPAT,ASL,ADSL,NIT2,ADSSL1,GLUL,GLS,ALDH4A1,RIMKLB,ASNS,GOT2,GAD1
ko00250	Alanine, aspartate and glutamate metabolism	0.178430312830283	-1.72355715830219	35	16	0.00629178136059772	2543	6908	84706,2673,9945,1373,5471,435,158,56954,122622,2752,2744,8659,57494,440,2806,2571	GPT2,GFPT1,GFPT2,CPS1,PPAT,ASL,ADSL,NIT2,ADSSL1,GLUL,GLS,ALDH4A1,RIMKLB,ASNS,GOT2,GAD1
ko00620	Pyruvate metabolism	0.180168069295788	-1.71386514542577	40	18	0.00707825403067243	2543	6908	5160,10873,4191,5315,197257,9380,39,5091,97,38,4190,4199,5106,4200,224,31,223,3945	PDHA1,ME3,MDH2,PKM,LDHD,GRHPR,ACAT2,PC,ACYP1,ACAT1,MDH1,ME1,PCK2,ME2,ALDH3A2,ACACA,ALDH9A1,LDHB
hsa00620	Pyruvate metabolism	0.180168069295788	-1.71386514542577	40	18	0.00707825403067243	2543	6908	5160,4191,10873,5315,197257,9380,39,5091,97,38,4190,4199,5106,4200,224,31,3945,223	PDHA1,MDH2,ME3,PKM,LDHD,GRHPR,ACAT2,PC,ACYP1,ACAT1,MDH1,ME1,PCK2,ME2,ALDH3A2,ACACA,LDHB,ALDH9A1
hsa04720	Long-term potentiation	0.204689183017089	-1.58626263081281	66	28	0.011010617381046	2543	6908	2033,468,673,5894,5604,5908,808,814,5532,3709,3710,5566,5501,5605,5595,1387,817,5906,6196,3708,5534,5500,5533,5499,5594,3265,5567,6197	EP300,ATF4,BRAF,RAF1,MAP2K1,RAP1B,CALM3,CAMK4,PPP3CB,ITPR2,ITPR3,PRKACA,PPP1CC,MAP2K2,MAPK3,CREBBP,CAMK2D,RAP1A,RPS6KA2,ITPR1,PPP3R1,PPP1CB,PPP3CC,PPP1CA,MAPK1,HRAS,PRKACB,RPS6KA3
ko04720	Long-term potentiation	0.204689183017089	-1.58626263081281	66	28	0.011010617381046	2543	6908	2033,468,673,5894,5604,5908,808,814,5532,3709,3710,5566,5501,5605,5595,1387,817,5906,6196,3708,5534,5500,5533,5499,5594,3265,5567,6197	EP300,ATF4,BRAF,RAF1,MAP2K1,RAP1B,CALM3,CAMK4,PPP3CB,ITPR2,ITPR3,PRKACA,PPP1CC,MAP2K2,MAPK3,CREBBP,CAMK2D,RAP1A,RPS6KA2,ITPR1,PPP3R1,PPP1CB,PPP3CC,PPP1CA,MAPK1,HRAS,PRKACB,RPS6KA3
hsa04662	B cell receptor signaling pathway	0.229574292426504	-1.47152858758899	72	30	0.0117970900511207	2543	6908	6655,3636,207,6654,5777,5894,208,5295,5879,7410,5604,10892,1147,5532,4067,5881,5605,8519,5595,2885,3551,5296,5534,8503,2932,5533,4793,5594,5970,3265	SOS2,INPPL1,AKT1,SOS1,PTPN6,RAF1,AKT2,PIK3R1,RAC1,VAV2,MAP2K1,MALT1,CHUK,PPP3CB,LYN,RAC3,MAP2K2,IFITM1,MAPK3,GRB2,IKBKB,PIK3R2,PPP3R1,PIK3R3,GSK3B,PPP3CC,NFKBIB,MAPK1,RELA,HRAS
ko04662	B cell receptor signaling pathway	0.229574292426504	-1.47152858758899	72	30	0.0117970900511207	2543	6908	6655,3636,207,6654,5777,5894,208,5295,5879,7410,5604,10892,1147,5532,4067,5881,5605,8519,5595,2885,3551,5296,5534,8503,2932,5533,4793,5594,5970,3265	SOS2,INPPL1,AKT1,SOS1,PTPN6,RAF1,AKT2,PIK3R1,RAC1,VAV2,MAP2K1,MALT1,CHUK,PPP3CB,LYN,RAC3,MAP2K2,IFITM1,MAPK3,GRB2,IKBKB,PIK3R2,PPP3R1,PIK3R3,GSK3B,PPP3CC,NFKBIB,MAPK1,RELA,HRAS
ko04962	Vasopressin-regulated water reabsorption	0.23329682792029	-1.45544369661688	44	19	0.00747149036570979	2543	6908	1781,9230,8655,5868,360,10488,6810,5869,5566,8766,2778,10671,115,51164,396,79659,5878,5567,1783	DYNC1I2,RAB11B,DYNLL1,RAB5A,AQP3,CREB3,STX4,RAB5B,PRKACA,RAB11A,GNAS,DCTN6,ADCY9,DCTN4,ARHGDIA,DYNC2H1,RAB5C,PRKACB,DYNC1LI2
hsa04962	Vasopressin-regulated water reabsorption	0.23329682792029	-1.45544369661688	44	19	0.00747149036570979	2543	6908	1781,9230,8655,5868,360,10488,6810,5869,5566,8766,2778,10671,115,51164,396,79659,5878,5567,1783	DYNC1I2,RAB11B,DYNLL1,RAB5A,AQP3,CREB3,STX4,RAB5B,PRKACA,RAB11A,GNAS,DCTN6,ADCY9,DCTN4,ARHGDIA,DYNC2H1,RAB5C,PRKACB,DYNC1LI2
ko00030	Pentose phosphate pathway	0.238357349405017	-1.43398426329853	29	13	0.00511207235548565	2543	6908	5236,55276,25796,5211,2539,230,226,64080,6120,6888,5214,5226,22934	PGM1,PGM2,PGLS,PFKL,G6PD,ALDOC,ALDOA,RBKS,RPE,TALDO1,PFKP,PGD,RPIA
hsa00030	Pentose phosphate pathway	0.238357349405017	-1.43398426329853	29	13	0.00511207235548565	2543	6908	5236,55276,25796,5211,2539,230,226,64080,6888,6120,5214,22934,5226	PGM1,PGM2,PGLS,PFKL,G6PD,ALDOC,ALDOA,RBKS,TALDO1,RPE,PFKP,RPIA,PGD
hsa04621	NOD-like receptor signaling pathway	0.24201074272731	-1.41877316237556	57	24	0.00943767204089658	2543	6908	5599,330,7128,7205,257397,3326,3606,1147,2920,55914,329,5595,10910,10392,23118,3569,5601,3551,3320,4793,841,5594,5970,10454	MAPK8,BIRC3,TNFAIP3,TRIP6,TAB3,HSP90AB1,IL18,CHUK,CXCL2,ERBB2IP,BIRC2,MAPK3,SUGT1,NOD1,TAB2,IL6,MAPK9,IKBKB,HSP90AA1,NFKBIB,CASP8,MAPK1,RELA,TAB1
ko04621	NOD-like receptor signaling pathway	0.24201074272731	-1.41877316237556	57	24	0.00943767204089658	2543	6908	5599,330,7128,7205,257397,3326,3606,1147,2920,55914,329,5595,10910,10392,23118,3569,5601,3551,3320,4793,841,5594,5970,10454	MAPK8,BIRC3,TNFAIP3,TRIP6,TAB3,HSP90AB1,IL18,CHUK,CXCL2,ERBB2IP,BIRC2,MAPK3,SUGT1,NOD1,TAB2,IL6,MAPK9,IKBKB,HSP90AA1,NFKBIB,CASP8,MAPK1,RELA,TAB1
ko04810	Regulation of actin cytoskeleton	0.247338012423115	-1.39699940650906	214	84	0.033031852143138	2543	6908	10163,10398,8936,71,5894,8826,5879,5604,22808,324,55740,81624,4628,5881,1399,55845,5296,54776,8503,5499,7414,4636,6655,54961,2257,7430,87,7114,2260,2934,1398,8976,3984,3673,3688,81,5500,60,6093,5594,10672,2245,85464,81873,673,4659,7410,10093,3693,5217,5501,10298,10092,9138,5062,6548,200576,22800,9475,3985,23191,10152,387,6237,6654,5295,79837,3678,23365,5747,8394,9564,10552,1729,5605,1073,10458,5595,2768,8396,4660,3685,10109,3265	WASF2,MYL9,WASF1,ACTG1,RAF1,IQGAP1,RAC1,MAP2K1,MRAS,APC,ENAH,DIAPH3,MYH10,RAC3,CRKL,BRK1,PIK3R2,PPP1R12C,PIK3R3,PPP1CA,VCL,MYL5,SOS2,SSH3,FGF12,EZR,ACTN1,TMSB4X,FGFR1,GSN,CRK,WASL,LIMK1,ITGA2,ITGB1,ACTN4,PPP1CB,ACTB,ROCK1,MAPK1,GNA13,FGD1,SSH2,ARPC5L,BRAF,PPP1R12A,VAV2,ARPC4,ITGB5,PFN2,PPP1CC,PAK4,ARPC5,ARHGEF1,PAK2,SLC9A1,PIKFYVE,RRAS2,ROCK2,LIMK2,CYFIP1,ABI2,RHOA,RRAS,SOS1,PIK3R1,PIP4K2C,ITGA5,ARHGEF12,PTK2,PIP5K1A,BCAR1,ARPC1A,DIAPH1,MAP2K2,CFL2,BAIAP2,MAPK3,GNA12,PIP4K2B,PPP1R12B,ITGAV,ARPC2,HRAS
hsa04810	Regulation of actin cytoskeleton	0.247338012423115	-1.39699940650906	214	84	0.033031852143138	2543	6908	10163,10398,8936,71,5894,8826,5879,5604,22808,324,55740,81624,4628,5881,1399,55845,5296,54776,8503,5499,7414,4636,6655,54961,2257,7430,87,7114,2260,2934,1398,8976,3984,3673,3688,81,5500,60,6093,5594,10672,2245,85464,81873,673,4659,7410,10093,3693,5217,5501,10298,10092,9138,5062,6548,200576,22800,9475,3985,23191,10152,387,6237,6654,5295,79837,3678,23365,5747,8394,9564,10552,1729,5605,1073,10458,5595,2768,8396,4660,3685,10109,3265	WASF2,MYL9,WASF1,ACTG1,RAF1,IQGAP1,RAC1,MAP2K1,MRAS,APC,ENAH,DIAPH3,MYH10,RAC3,CRKL,BRK1,PIK3R2,PPP1R12C,PIK3R3,PPP1CA,VCL,MYL5,SOS2,SSH3,FGF12,EZR,ACTN1,TMSB4X,FGFR1,GSN,CRK,WASL,LIMK1,ITGA2,ITGB1,ACTN4,PPP1CB,ACTB,ROCK1,MAPK1,GNA13,FGD1,SSH2,ARPC5L,BRAF,PPP1R12A,VAV2,ARPC4,ITGB5,PFN2,PPP1CC,PAK4,ARPC5,ARHGEF1,PAK2,SLC9A1,PIKFYVE,RRAS2,ROCK2,LIMK2,CYFIP1,ABI2,RHOA,RRAS,SOS1,PIK3R1,PIP4K2C,ITGA5,ARHGEF12,PTK2,PIP5K1A,BCAR1,ARPC1A,DIAPH1,MAP2K2,CFL2,BAIAP2,MAPK3,GNA12,PIP4K2B,PPP1R12B,ITGAV,ARPC2,HRAS
hsa05214	Glioma	0.25130088741222	-1.38110430315263	65	27	0.0106173810460087	2543	6908	6655,673,207,2475,6654,5894,208,7039,5295,5604,1871,808,1026,5605,5595,2885,5335,817,4193,6464,5296,8503,5594,1870,3265,1021,1029	SOS2,BRAF,AKT1,MTOR,SOS1,RAF1,AKT2,TGFA,PIK3R1,MAP2K1,E2F3,CALM3,CDKN1A,MAP2K2,MAPK3,GRB2,PLCG1,CAMK2D,MDM2,SHC1,PIK3R2,PIK3R3,MAPK1,E2F2,HRAS,CDK6,CDKN2A
ko05214	Glioma	0.25130088741222	-1.38110430315263	65	27	0.0106173810460087	2543	6908	6655,673,207,2475,6654,5894,208,7039,5295,5604,1871,808,1026,5605,5595,2885,5335,817,4193,6464,5296,8503,5594,1870,3265,1021,1029	SOS2,BRAF,AKT1,MTOR,SOS1,RAF1,AKT2,TGFA,PIK3R1,MAP2K1,E2F3,CALM3,CDKN1A,MAP2K2,MAPK3,GRB2,PLCG1,CAMK2D,MDM2,SHC1,PIK3R2,PIK3R3,MAPK1,E2F2,HRAS,CDK6,CDKN2A
hsa04310	Wnt signaling pathway	0.26160303088137	-1.34092707352825	141	56	0.022021234762092	2543	6908	2033,5599,23291,64840,8325,5879,51701,8454,324,1488,5532,2535,1452,5566,5881,7474,56998,1387,1499,6477,57680,896,5601,4040,9475,1856,5567,8321,387,7480,8322,9978,1454,7976,23401,1857,7481,6934,8324,22943,4088,80319,5467,817,25805,10023,8326,5534,2932,5533,4776,27101,6907,7855,4089,1487	EP300,MAPK8,FBXW11,PORCN,FZD8,RAC1,NLK,CUL1,APC,CTBP2,PPP3CB,FZD2,CSNK1A1,PRKACA,RAC3,WNT5A,CTNNBIP1,CREBBP,CTNNB1,SIAH1,CHD8,CCND3,MAPK9,LRP6,ROCK2,DVL2,PRKACB,FZD1,RHOA,WNT10B,FZD4,RBX1,CSNK1E,FZD3,FRAT2,DVL3,WNT11,TCF7L2,FZD7,DKK1,SMAD3,CXXC4,PPARD,CAMK2D,BAMBI,FRAT1,FZD9,PPP3R1,GSK3B,PPP3CC,NFATC4,CACYBP,TBL1X,FZD5,SMAD4,CTBP1
ko04310	Wnt signaling pathway	0.26160303088137	-1.34092707352825	141	56	0.022021234762092	2543	6908	2033,5599,23291,64840,8325,5879,51701,8454,324,1488,5532,2535,1452,5566,5881,7474,56998,1387,1499,6477,57680,896,5601,4040,9475,1856,5567,8321,387,7480,8322,9978,1454,7976,23401,1857,7481,6934,8324,22943,4088,80319,5467,817,25805,10023,8326,5534,2932,5533,4776,27101,6907,7855,4089,1487	EP300,MAPK8,FBXW11,PORCN,FZD8,RAC1,NLK,CUL1,APC,CTBP2,PPP3CB,FZD2,CSNK1A1,PRKACA,RAC3,WNT5A,CTNNBIP1,CREBBP,CTNNB1,SIAH1,CHD8,CCND3,MAPK9,LRP6,ROCK2,DVL2,PRKACB,FZD1,RHOA,WNT10B,FZD4,RBX1,CSNK1E,FZD3,FRAT2,DVL3,WNT11,TCF7L2,FZD7,DKK1,SMAD3,CXXC4,PPARD,CAMK2D,BAMBI,FRAT1,FZD9,PPP3R1,GSK3B,PPP3CC,NFATC4,CACYBP,TBL1X,FZD5,SMAD4,CTBP1
ko04966	Collecting duct acid secretion	0.263157232958557	-1.33500358149299	27	12	0.00471883602044829	2543	6908	10723,51382,10312,523,535,23545,527,528,529,8992,9114,9550	SLC12A7,ATP6V1D,TCIRG1,ATP6V1A,ATP6V0A1,ATP6V0A2,ATP6V0C,ATP6V1C1,ATP6V1E1,ATP6V0E1,ATP6V0D1,ATP6V1G1
hsa04966	Collecting duct acid secretion	0.263157232958557	-1.33500358149299	27	12	0.00471883602044829	2543	6908	10723,51382,10312,523,535,23545,527,528,529,8992,9114,9550	SLC12A7,ATP6V1D,TCIRG1,ATP6V1A,ATP6V0A1,ATP6V0A2,ATP6V0C,ATP6V1C1,ATP6V1E1,ATP6V0E1,ATP6V0D1,ATP6V1G1
hsa00524	Butirosin and neomycin biosynthesis	0.263898494425921	-1.33219074058227	5	3	0.00117970900511207	2543	6908	80201,3098,3101	HKDC1,HK1,HK3
ko00524	Butirosin and neomycin biosynthesis	0.263898494425921	-1.33219074058227	5	3	0.00117970900511207	2543	6908	80201,3098,3101	HKDC1,HK1,HK3
ko05168	Herpes simplex infection	0.278451354252069	-1.2785119054206	184	72	0.0283130161226897	2543	6908	5599,2033,836,6890,9451,8454,1147,3661,1387,3592,5610,6427,6672,3551,6429,6891,5499,4940,3459,841,2969,29915,5970,3054,6881,6877,29997,7297,983,6773,9021,7185,1616,23118,5187,406,5500,148022,9575,10454,6884,6908,7186,10482,9569,440275,5501,3105,112950,83860,5601,5781,3717,54926,1936,3150,10445,29110,6502,6430,3454,6875,5430,997,3569,9519,3190,1965,6428,4793,6878,64135	MAPK8,EP300,CASP3,TAP1,EIF2AK3,CUL1,CHUK,IRF3,CREBBP,IL12A,EIF2AK2,SRSF2,SP100,IKBKB,SRSF4,TAP2,PPP1CA,OAS3,IFNGR1,CASP8,GTF2I,HCFC2,RELA,HCFC1,TAF10,TAF5,GLTSCR2,TYK2,CDK1,STAT2,SOCS3,TRAF1,DAXX,TAB2,PER1,ARNTL,PPP1CB,TICAM1,CLOCK,TAB1,TAF13,TBP,TRAF2,NXF1,GTF2IRD1,EIF2AK4,PPP1CC,HLA-A,MED8,TAF3,MAPK9,PTPN11,JAK2,UBE2R2,EEF1D,HMGN1,MCRS1,TBK1,SKP2,SRSF5,IFNAR1,TAF4B,POLR2A,CDC34,IL6,TBPL1,HNRNPK,EIF2S1,SRSF3,NFKBIB,TAF6,IFIH1
hsa05168	Herpes simplex infection	0.278451354252069	-1.2785119054206	184	72	0.0283130161226897	2543	6908	5599,2033,836,6890,9451,8454,1147,3661,1387,3592,5610,6427,6672,3551,6429,6891,5499,4940,3459,841,2969,29915,5970,3054,6881,6877,29997,7297,983,6773,9021,7185,1616,23118,5187,406,5500,148022,9575,10454,6884,6908,7186,10482,9569,440275,5501,3105,112950,83860,5601,5781,3717,54926,1936,3150,10445,29110,6502,6430,3454,6875,5430,997,3569,9519,3190,1965,6428,4793,6878,64135	MAPK8,EP300,CASP3,TAP1,EIF2AK3,CUL1,CHUK,IRF3,CREBBP,IL12A,EIF2AK2,SRSF2,SP100,IKBKB,SRSF4,TAP2,PPP1CA,OAS3,IFNGR1,CASP8,GTF2I,HCFC2,RELA,HCFC1,TAF10,TAF5,GLTSCR2,TYK2,CDK1,STAT2,SOCS3,TRAF1,DAXX,TAB2,PER1,ARNTL,PPP1CB,TICAM1,CLOCK,TAB1,TAF13,TBP,TRAF2,NXF1,GTF2IRD1,EIF2AK4,PPP1CC,HLA-A,MED8,TAF3,MAPK9,PTPN11,JAK2,UBE2R2,EEF1D,HMGN1,MCRS1,TBK1,SKP2,SRSF5,IFNAR1,TAF4B,POLR2A,CDC34,IL6,TBPL1,HNRNPK,EIF2S1,SRSF3,NFKBIB,TAF6,IFIH1
ko04260	Cardiac muscle contraction	0.289684835151408	-1.23896172231012	74	30	0.0117970900511207	2543	6908	1329,1350,7169,7170,7381,27089,29796,7171,59285,1327,7384,481,785,59283,476,488,1337,783,10479,9167,1351,7385,6548,482,7388,10975,784,1349,7168,781	COX5B,COX7C,TPM2,TPM3,UQCRB,UQCRQ,UQCR10,TPM4,CACNG6,COX4I1,UQCRC1,ATP1B1,CACNB4,CACNG8,ATP1A1,ATP2A2,COX6A1,CACNB2,SLC9A6,COX7A2L,COX8A,UQCRC2,SLC9A1,ATP1B2,UQCRH,UQCR11,CACNB3,COX7B,TPM1,CACNA2D1
hsa04260	Cardiac muscle contraction	0.289684835151408	-1.23896172231012	74	30	0.0117970900511207	2543	6908	1329,1350,7169,7170,7381,27089,29796,7171,59285,1327,7384,481,785,59283,476,488,1337,783,10479,9167,1351,7385,6548,482,7388,10975,784,1349,7168,781	COX5B,COX7C,TPM2,TPM3,UQCRB,UQCRQ,UQCR10,TPM4,CACNG6,COX4I1,UQCRC1,ATP1B1,CACNB4,CACNG8,ATP1A1,ATP2A2,COX6A1,CACNB2,SLC9A6,COX7A2L,COX8A,UQCRC2,SLC9A1,ATP1B2,UQCRH,UQCR11,CACNB3,COX7B,TPM1,CACNA2D1
hsa00100	Steroid biosynthesis	0.294093976488491	-1.22385591479993	20	9	0.00353912701533622	2543	6908	1591,4047,6307,50814,7108,1717,6309,2222,10682	CYP24A1,LSS,MSMO1,NSDHL,TM7SF2,DHCR7,SC5D,FDFT1,EBP
ko00100	Steroid biosynthesis	0.294093976488491	-1.22385591479993	20	9	0.00353912701533622	2543	6908	1591,4047,6307,50814,7108,1717,6309,10682,2222	CYP24A1,LSS,MSMO1,NSDHL,TM7SF2,DHCR7,SC5D,EBP,FDFT1
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	0.294774497167935	-1.22154463133737	15	7	0.0027526543452615	2543	6908	10678,11041,8702,6482,6487,8704,9435	B3GNT2,B4GAT1,B4GALT4,ST3GAL1,ST3GAL3,B4GALT2,CHST2
hsa00604	Glycosphingolipid biosynthesis - ganglio series	0.294774497167935	-1.22154463133737	15	7	0.0027526543452615	2543	6908	2720,256435,6482,8705,3073,2583,9197	GLB1,ST6GALNAC3,ST3GAL1,B3GALT4,HEXA,B4GALNT1,SLC33A1
hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	0.294774497167935	-1.22154463133737	15	7	0.0027526543452615	2543	6908	10678,11041,8702,6482,6487,8704,9435	B3GNT2,B4GAT1,B4GALT4,ST3GAL1,ST3GAL3,B4GALT2,CHST2
ko00604	Glycosphingolipid biosynthesis - ganglio series	0.294774497167935	-1.22154463133737	15	7	0.0027526543452615	2543	6908	2720,256435,6482,8705,3073,2583,9197	GLB1,ST6GALNAC3,ST3GAL1,B3GALT4,HEXA,B4GALNT1,SLC33A1
hsa04210	Apoptosis	0.306102119320673	-1.18383650943281	85	34	0.0133700353912702	2543	6908	836,1676,839,7186,2021,9131,1147,5532,598,5566,329,824,3551,5296,51135,581,8503,841,9020,5970,3556,5567,330,207,208,842,5295,8743,840,5534,5533,317,8793,823	CASP3,DFFA,CASP6,TRAF2,ENDOG,AIFM1,CHUK,PPP3CB,BCL2L1,PRKACA,BIRC2,CAPN2,IKBKB,PIK3R2,IRAK4,BAX,PIK3R3,CASP8,MAP3K14,RELA,IL1RAP,PRKACB,BIRC3,AKT1,AKT2,CASP9,PIK3R1,TNFSF10,CASP7,PPP3R1,PPP3CC,APAF1,TNFRSF10D,CAPN1
ko04210	Apoptosis	0.306102119320673	-1.18383650943281	85	34	0.0133700353912702	2543	6908	836,1676,839,7186,2021,9131,1147,5532,598,5566,329,824,3551,5296,51135,581,8503,841,9020,5970,3556,5567,330,207,208,842,5295,8743,840,5534,5533,317,8793,823	CASP3,DFFA,CASP6,TRAF2,ENDOG,AIFM1,CHUK,PPP3CB,BCL2L1,PRKACA,BIRC2,CAPN2,IKBKB,PIK3R2,IRAK4,BAX,PIK3R3,CASP8,MAP3K14,RELA,IL1RAP,PRKACB,BIRC3,AKT1,AKT2,CASP9,PIK3R1,TNFSF10,CASP7,PPP3R1,PPP3CC,APAF1,TNFRSF10D,CAPN1
ko01220	Degradation of aromatic compounds	0.306746212632158	-1.18173454222477	3	2	0.000786472670074715	2543	6908	128,10327	ADH5,AKR1A1
hsa01220	Degradation of aromatic compounds	0.306746212632158	-1.18173454222477	3	2	0.000786472670074715	2543	6908	128,10327	ADH5,AKR1A1
ko00561	Glycerolipid metabolism	0.311620996070789	-1.16596758577037	59	24	0.00943767204089658	2543	6908	2710,56895,84803,8612,10554,56894,8527,9388,64900,253558,137964,10327,8611,55326,84649,231,154141,57678,2717,8694,129642,224,132158,223	GK,AGPAT4,GPAT3,PLPP2,AGPAT1,AGPAT3,DGKD,LIPG,LPIN3,LCLAT1,GPAT4,AKR1A1,PLPP1,AGPAT5,DGAT2,AKR1B1,MBOAT1,GPAM,GLA,DGAT1,MBOAT2,ALDH3A2,GLYCTK,ALDH9A1
hsa00561	Glycerolipid metabolism	0.311620996070789	-1.16596758577037	59	24	0.00943767204089658	2543	6908	2710,56895,84803,8612,10554,8527,9388,56894,64900,253558,10327,137964,8611,55326,84649,231,154141,2717,57678,8694,129642,224,132158,223	GK,AGPAT4,GPAT3,PLPP2,AGPAT1,DGKD,LIPG,AGPAT3,LPIN3,LCLAT1,AKR1A1,GPAT4,PLPP1,AGPAT5,DGAT2,AKR1B1,MBOAT1,GLA,GPAM,DGAT1,MBOAT2,ALDH3A2,GLYCTK,ALDH9A1
ko00640	Propanoate metabolism	0.315372840066154	-1.1539997208239	28	12	0.00471883602044829	2543	6908	84693,5096,39,8802,1962,4329,1892,38,8801,55862,31,3945	MCEE,PCCB,ACAT2,SUCLG1,EHHADH,ALDH6A1,ECHS1,ACAT1,SUCLG2,ECHDC1,ACACA,LDHB
hsa00640	Propanoate metabolism	0.315372840066154	-1.1539997208239	28	12	0.00471883602044829	2543	6908	84693,5096,39,8802,1962,4329,1892,38,8801,55862,31,3945	MCEE,PCCB,ACAT2,SUCLG1,EHHADH,ALDH6A1,ECHS1,ACAT1,SUCLG2,ECHDC1,ACACA,LDHB
ko04071	Sphingolipid signaling pathway	0.326266645346122	-1.12004030142872	120	47	0.0184821077467558	2543	6908	5599,5894,7186,5879,91012,5604,8877,5520,427,5881,5519,5581,5296,5601,581,8503,5521,2771,5970,9475,5170,387,53637,207,208,5295,2773,9517,5605,8439,5595,2770,2768,5529,2534,253782,8560,5590,5527,6093,5337,4217,56848,5594,10672,5528,3265	MAPK8,RAF1,TRAF2,RAC1,CERS5,MAP2K1,SPHK1,PPP2R2A,ASAH1,RAC3,PPP2R1B,PRKCE,PIK3R2,MAPK9,BAX,PIK3R3,PPP2R2B,GNAI2,RELA,ROCK2,PDPK1,RHOA,S1PR5,AKT1,AKT2,PIK3R1,GNAI3,SPTLC2,MAP2K2,NSMAF,MAPK3,GNAI1,GNA12,PPP2R5E,FYN,CERS6,DEGS1,PRKCZ,PPP2R5C,ROCK1,PLD1,MAP3K5,SPHK2,MAPK1,GNA13,PPP2R5D,HRAS
hsa04071	Sphingolipid signaling pathway	0.326266645346122	-1.12004030142872	120	47	0.0184821077467558	2543	6908	5599,5894,7186,5879,91012,5604,8877,5520,427,5881,5519,5581,5296,5601,581,8503,5521,2771,5970,9475,5170,387,53637,207,208,5295,2773,9517,5605,8439,5595,2770,2768,5529,2534,253782,8560,5590,5527,6093,5337,4217,56848,5594,10672,5528,3265	MAPK8,RAF1,TRAF2,RAC1,CERS5,MAP2K1,SPHK1,PPP2R2A,ASAH1,RAC3,PPP2R1B,PRKCE,PIK3R2,MAPK9,BAX,PIK3R3,PPP2R2B,GNAI2,RELA,ROCK2,PDPK1,RHOA,S1PR5,AKT1,AKT2,PIK3R1,GNAI3,SPTLC2,MAP2K2,NSMAF,MAPK3,GNAI1,GNA12,PPP2R5E,FYN,CERS6,DEGS1,PRKCZ,PPP2R5C,ROCK1,PLD1,MAP3K5,SPHK2,MAPK1,GNA13,PPP2R5D,HRAS
hsa00770	Pantothenate and CoA biosynthesis	0.328611387157024	-1.11287942042789	18	8	0.00314589068029886	2543	6908	80025,60496,79717,55229,53354,1806,79646,587	PANK2,AASDHPPT,PPCS,PANK4,PANK1,DPYD,PANK3,BCAT2
ko00770	Pantothenate and CoA biosynthesis	0.328611387157024	-1.11287942042789	18	8	0.00314589068029886	2543	6908	80025,1806,60496,79717,55229,79646,53354,587	PANK2,DPYD,AASDHPPT,PPCS,PANK4,PANK3,PANK1,BCAT2
hsa04664	Fc epsilon RI signaling pathway	0.330109649126559	-1.10833040963061	70	28	0.011010617381046	2543	6908	5170,5599,6655,207,5609,6654,5894,208,5295,5879,7410,5604,4067,5881,5605,5606,5595,2885,5581,5335,2534,5608,5296,5601,8503,5594,3265,6416	PDPK1,MAPK8,SOS2,AKT1,MAP2K7,SOS1,RAF1,AKT2,PIK3R1,RAC1,VAV2,MAP2K1,LYN,RAC3,MAP2K2,MAP2K3,MAPK3,GRB2,PRKCE,PLCG1,FYN,MAP2K6,PIK3R2,MAPK9,PIK3R3,MAPK1,HRAS,MAP2K4
ko04664	Fc epsilon RI signaling pathway	0.330109649126559	-1.10833040963061	70	28	0.011010617381046	2543	6908	5170,5599,6655,207,5609,6654,5894,208,5295,5879,7410,5604,4067,5881,5605,5606,5595,2885,5581,5335,2534,5608,5296,5601,8503,5594,3265,6416	PDPK1,MAPK8,SOS2,AKT1,MAP2K7,SOS1,RAF1,AKT2,PIK3R1,RAC1,VAV2,MAP2K1,LYN,RAC3,MAP2K2,MAP2K3,MAPK3,GRB2,PRKCE,PLCG1,FYN,MAP2K6,PIK3R2,MAPK9,PIK3R3,MAPK1,HRAS,MAP2K4
ko04915	Estrogen signaling pathway	0.330505841066118	-1.10713094642412	99	39	0.0153362170664569	2543	6908	1388,5894,2550,5604,808,3709,10488,5566,3303,6464,5296,115,8503,3320,2771,1386,5567,6667,6655,468,207,6654,3326,208,5295,3710,2100,2773,5605,3304,5595,2770,2885,2778,3305,3708,2852,5594,3265	ATF6B,RAF1,GABBR1,MAP2K1,CALM3,ITPR2,CREB3,PRKACA,HSPA1A,SHC1,PIK3R2,ADCY9,PIK3R3,HSP90AA1,GNAI2,ATF2,PRKACB,SP1,SOS2,ATF4,AKT1,SOS1,HSP90AB1,AKT2,PIK3R1,ITPR3,ESR2,GNAI3,MAP2K2,HSPA1B,MAPK3,GNAI1,GRB2,GNAS,HSPA1L,ITPR1,GPER1,MAPK1,HRAS
hsa04915	Estrogen signaling pathway	0.330505841066118	-1.10713094642412	99	39	0.0153362170664569	2543	6908	1388,5894,2550,5604,808,3709,10488,5566,3303,6464,5296,115,8503,3320,2771,1386,5567,6667,6655,468,207,6654,3326,208,5295,3710,2100,2773,5605,3304,5595,2770,2885,2778,3305,3708,2852,5594,3265	ATF6B,RAF1,GABBR1,MAP2K1,CALM3,ITPR2,CREB3,PRKACA,HSPA1A,SHC1,PIK3R2,ADCY9,PIK3R3,HSP90AA1,GNAI2,ATF2,PRKACB,SP1,SOS2,ATF4,AKT1,SOS1,HSP90AB1,AKT2,PIK3R1,ITPR3,ESR2,GNAI3,MAP2K2,HSPA1B,MAPK3,GNAI1,GRB2,GNAS,HSPA1L,ITPR1,GPER1,MAPK1,HRAS
hsa00061	Fatty acid biosynthesis	0.333443065272137	-1.09828314702475	13	6	0.00235941801022414	2543	6908	27349,2180,2182,2181,31,2194	MCAT,ACSL1,ACSL4,ACSL3,ACACA,FASN
ko00061	Fatty acid biosynthesis	0.333443065272137	-1.09828314702475	13	6	0.00235941801022414	2543	6908	27349,2182,2180,2181,31,2194	MCAT,ACSL4,ACSL1,ACSL3,ACACA,FASN
ko00514	Other types of O-glycan biosynthesis	0.337625523780546	-1.08581791550278	31	13	0.00511207235548565	2543	6908	283464,56983,8705,3955,6480,8473,79709,8985,55624,10585,23509,6487,8704	GXYLT1,POGLUT1,B3GALT4,LFNG,ST6GAL1,OGT,COLGALT1,PLOD3,POMGNT1,POMT1,POFUT1,ST3GAL3,B4GALT2
hsa04710	Circadian rhythm	0.337625523780546	-1.08581791550278	31	13	0.00511207235548565	2543	6908	23291,51422,9978,5187,1454,5565,406,5562,5571,8454,1408,9575,1407	FBXW11,PRKAG2,RBX1,PER1,CSNK1E,PRKAB2,ARNTL,PRKAA1,PRKAG1,CUL1,CRY2,CLOCK,CRY1
ko04710	Circadian rhythm	0.337625523780546	-1.08581791550278	31	13	0.00511207235548565	2543	6908	23291,51422,9978,5187,1454,5565,406,5562,5571,8454,1408,9575,1407	FBXW11,PRKAG2,RBX1,PER1,CSNK1E,PRKAB2,ARNTL,PRKAA1,PRKAG1,CUL1,CRY2,CLOCK,CRY1
hsa00514	Other types of O-glycan biosynthesis	0.337625523780546	-1.08581791550278	31	13	0.00511207235548565	2543	6908	283464,56983,8705,3955,6480,8473,79709,8985,55624,10585,6487,23509,8704	GXYLT1,POGLUT1,B3GALT4,LFNG,ST6GAL1,OGT,COLGALT1,PLOD3,POMGNT1,POMT1,ST3GAL3,POFUT1,B4GALT2
hsa04550	Signaling pathways regulating pluripotency of stem cells	0.34548793869632	-1.06279754609051	142	55	0.0216279984270547	2543	6908	90,3397,659,5894,8325,6929,55183,5013,5604,3398,4090,324,2535,7474,1499,3572,5296,92,8503,3717,6774,4211,1856,8321,10336,207,7480,8322,208,56916,7976,5295,84108,7481,1857,5605,2260,8324,5595,2885,4088,3399,4087,9314,8326,6926,2932,657,4086,7855,5594,3265,4089,9869,7994	ACVR1,ID1,BMPR2,RAF1,FZD8,TCF3,RIF1,OTX1,MAP2K1,ID2,SMAD5,APC,FZD2,WNT5A,CTNNB1,IL6ST,PIK3R2,ACVR2A,PIK3R3,JAK2,STAT3,MEIS1,DVL2,FZD1,PCGF3,AKT1,WNT10B,FZD4,AKT2,SMARCAD1,FZD3,PIK3R1,PCGF6,WNT11,DVL3,MAP2K2,FGFR1,FZD7,MAPK3,GRB2,SMAD3,ID3,SMAD2,KLF4,FZD9,TBX3,GSK3B,BMPR1A,SMAD1,FZD5,MAPK1,HRAS,SMAD4,SETDB1,KAT6A
ko04550	Signaling pathways regulating pluripotency of stem cells	0.34548793869632	-1.06279754609051	142	55	0.0216279984270547	2543	6908	90,3397,659,5894,8325,6929,55183,5013,5604,3398,4090,324,2535,7474,1499,3572,5296,92,8503,3717,6774,4211,1856,8321,10336,207,7480,8322,208,56916,7976,5295,84108,7481,1857,5605,2260,8324,5595,2885,4088,3399,4087,9314,8326,6926,2932,657,4086,7855,5594,3265,4089,9869,7994	ACVR1,ID1,BMPR2,RAF1,FZD8,TCF3,RIF1,OTX1,MAP2K1,ID2,SMAD5,APC,FZD2,WNT5A,CTNNB1,IL6ST,PIK3R2,ACVR2A,PIK3R3,JAK2,STAT3,MEIS1,DVL2,FZD1,PCGF3,AKT1,WNT10B,FZD4,AKT2,SMARCAD1,FZD3,PIK3R1,PCGF6,WNT11,DVL3,MAP2K2,FGFR1,FZD7,MAPK3,GRB2,SMAD3,ID3,SMAD2,KLF4,FZD9,TBX3,GSK3B,BMPR1A,SMAD1,FZD5,MAPK1,HRAS,SMAD4,SETDB1,KAT6A
hsa04022	cGMP-PKG signaling pathway	0.368979843094653	-0.997013262193399	167	64	0.0251671254423909	2543	6908	10398,5894,5604,3709,5139,488,5296,115,8503,7419,5499,2969,1386,151,10105,468,207,208,7417,100271849,4209,481,7416,3710,2773,2770,8660,476,291,5500,6722,482,5533,6093,10672,5594,4659,1388,808,9569,4205,10488,5532,5997,5501,5581,7408,2771,9475,387,2626,5295,8654,4881,154,5605,2767,5595,2768,3643,3708,5534,4776,493	MYL9,RAF1,MAP2K1,ITPR2,PDE3A,ATP2A2,PIK3R2,ADCY9,PIK3R3,VDAC3,PPP1CA,GTF2I,ATF2,ADRA2B,PPIF,ATF4,AKT1,AKT2,VDAC2,MEF2B,MEF2D,ATP1B1,VDAC1,ITPR3,GNAI3,GNAI1,IRS2,ATP1A1,SLC25A4,PPP1CB,SRF,ATP1B2,PPP3CC,ROCK1,GNA13,MAPK1,PPP1R12A,ATF6B,CALM3,GTF2IRD1,MEF2A,CREB3,PPP3CB,RGS2,PPP1CC,PRKCE,VASP,GNAI2,ROCK2,RHOA,GATA4,PIK3R1,PDE5A,NPR1,ADRB2,MAP2K2,GNA11,MAPK3,GNA12,INSR,ITPR1,PPP3R1,NFATC4,ATP2B4
ko04022	cGMP-PKG signaling pathway	0.368979843094653	-0.997013262193399	167	64	0.0251671254423909	2543	6908	10398,5894,5604,3709,5139,488,5296,115,8503,7419,5499,2969,1386,151,10105,468,207,208,7417,100271849,4209,481,7416,3710,2773,2770,8660,476,291,5500,6722,482,5533,6093,10672,5594,4659,1388,808,9569,4205,10488,5532,5997,5501,5581,7408,2771,9475,387,2626,5295,8654,4881,154,5605,2767,5595,2768,3643,3708,5534,4776,493	MYL9,RAF1,MAP2K1,ITPR2,PDE3A,ATP2A2,PIK3R2,ADCY9,PIK3R3,VDAC3,PPP1CA,GTF2I,ATF2,ADRA2B,PPIF,ATF4,AKT1,AKT2,VDAC2,MEF2B,MEF2D,ATP1B1,VDAC1,ITPR3,GNAI3,GNAI1,IRS2,ATP1A1,SLC25A4,PPP1CB,SRF,ATP1B2,PPP3CC,ROCK1,GNA13,MAPK1,PPP1R12A,ATF6B,CALM3,GTF2IRD1,MEF2A,CREB3,PPP3CB,RGS2,PPP1CC,PRKCE,VASP,GNAI2,ROCK2,RHOA,GATA4,PIK3R1,PDE5A,NPR1,ADRB2,MAP2K2,GNA11,MAPK3,GNA12,INSR,ITPR1,PPP3R1,NFATC4,ATP2B4
ko04921	Oxytocin signaling pathway	0.385276457448335	-0.953794131089816	157	60	0.0235941801022414	2543	6908	10398,5607,4659,71,84254,5565,8536,5894,5562,59285,5604,814,808,5532,1026,3709,5997,785,5566,5501,140465,59283,1938,783,5296,115,54776,8503,4637,5499,5598,2771,9475,5567,387,3759,5295,4881,5571,3710,2773,5605,5595,2770,2778,5743,817,51422,3708,5534,5500,4660,60,5533,6093,784,4776,5594,3265,781	MYL9,MAP2K5,PPP1R12A,ACTG1,CAMKK1,PRKAB2,CAMK1,RAF1,PRKAA1,CACNG6,MAP2K1,CAMK4,CALM3,PPP3CB,CDKN1A,ITPR2,RGS2,CACNB4,PRKACA,PPP1CC,MYL6B,CACNG8,EEF2,CACNB2,PIK3R2,ADCY9,PPP1R12C,PIK3R3,MYL6,PPP1CA,MAPK7,GNAI2,ROCK2,PRKACB,RHOA,KCNJ2,PIK3R1,NPR1,PRKAG1,ITPR3,GNAI3,MAP2K2,MAPK3,GNAI1,GNAS,PTGS2,CAMK2D,PRKAG2,ITPR1,PPP3R1,PPP1CB,PPP1R12B,ACTB,PPP3CC,ROCK1,CACNB3,NFATC4,MAPK1,HRAS,CACNA2D1
hsa04921	Oxytocin signaling pathway	0.385276457448335	-0.953794131089816	157	60	0.0235941801022414	2543	6908	10398,5607,4659,71,84254,5565,8536,5894,5562,59285,5604,814,808,5532,1026,3709,5997,785,5566,5501,140465,59283,1938,783,5296,115,54776,8503,4637,5499,5598,2771,9475,5567,387,3759,5295,4881,5571,3710,2773,5605,5595,2770,2778,5743,817,51422,3708,5534,5500,4660,60,5533,6093,784,4776,5594,3265,781	MYL9,MAP2K5,PPP1R12A,ACTG1,CAMKK1,PRKAB2,CAMK1,RAF1,PRKAA1,CACNG6,MAP2K1,CAMK4,CALM3,PPP3CB,CDKN1A,ITPR2,RGS2,CACNB4,PRKACA,PPP1CC,MYL6B,CACNG8,EEF2,CACNB2,PIK3R2,ADCY9,PPP1R12C,PIK3R3,MYL6,PPP1CA,MAPK7,GNAI2,ROCK2,PRKACB,RHOA,KCNJ2,PIK3R1,NPR1,PRKAG1,ITPR3,GNAI3,MAP2K2,MAPK3,GNAI1,GNAS,PTGS2,CAMK2D,PRKAG2,ITPR1,PPP3R1,PPP1CB,PPP1R12B,ACTB,PPP3CC,ROCK1,CACNB3,NFATC4,MAPK1,HRAS,CACNA2D1
ko04370	VEGF signaling pathway	0.3863543062251	-0.951000438747485	61	24	0.00943767204089658	2543	6908	207,7867,5894,208,5295,5879,842,5604,8877,5532,5747,7422,5881,5605,5595,5743,5335,5296,5534,8503,5533,5594,56848,3265	AKT1,MAPKAPK3,RAF1,AKT2,PIK3R1,RAC1,CASP9,MAP2K1,SPHK1,PPP3CB,PTK2,VEGFA,RAC3,MAP2K2,MAPK3,PTGS2,PLCG1,PIK3R2,PPP3R1,PIK3R3,PPP3CC,MAPK1,SPHK2,HRAS
hsa04370	VEGF signaling pathway	0.3863543062251	-0.951000438747485	61	24	0.00943767204089658	2543	6908	207,7867,5894,208,5295,5879,842,5604,8877,5532,5747,7422,5881,5605,5595,5743,5335,5296,5534,8503,5533,5594,56848,3265	AKT1,MAPKAPK3,RAF1,AKT2,PIK3R1,RAC1,CASP9,MAP2K1,SPHK1,PPP3CB,PTK2,VEGFA,RAC3,MAP2K2,MAPK3,PTGS2,PLCG1,PIK3R2,PPP3R1,PIK3R3,PPP3CC,MAPK1,SPHK2,HRAS
ko03320	PPAR signaling pathway	0.387614722474742	-0.947743416005922	69	27	0.0106173810460087	2543	6908	5170,2170,2710,10580,2180,1962,11001,5468,79966,2181,6256,5465,6342,1375,6319,30,7316,6257,5467,51,1622,10999,4199,2182,5106,5360,8310	PDPK1,FABP3,GK,SORBS1,ACSL1,EHHADH,SLC27A2,PPARG,SCD5,ACSL3,RXRA,PPARA,SCP2,CPT1B,SCD,ACAA1,UBC,RXRB,PPARD,ACOX1,DBI,SLC27A4,ME1,ACSL4,PCK2,PLTP,ACOX3
hsa03320	PPAR signaling pathway	0.387614722474742	-0.947743416005922	69	27	0.0106173810460087	2543	6908	2170,5170,2710,10580,2180,1962,11001,5468,79966,2181,6256,5465,6342,6319,1375,30,7316,6257,5467,51,1622,10999,4199,2182,5106,5360,8310	FABP3,PDPK1,GK,SORBS1,ACSL1,EHHADH,SLC27A2,PPARG,SCD5,ACSL3,RXRA,PPARA,SCP2,SCD,CPT1B,ACAA1,UBC,RXRB,PPARD,ACOX1,DBI,SLC27A4,ME1,ACSL4,PCK2,PLTP,ACOX3
hsa00531	Glycosaminoglycan degradation	0.397501208883331	-0.922557303676448	19	8	0.00314589068029886	2543	6908	3423,3373,2720,6448,10855,138050,3073,3425	IDS,HYAL1,GLB1,SGSH,HPSE,HGSNAT,HEXA,IDUA
ko00531	Glycosaminoglycan degradation	0.397501208883331	-0.922557303676448	19	8	0.00314589068029886	2543	6908	3423,3373,2720,6448,138050,10855,3073,3425	IDS,HYAL1,GLB1,SGSH,HGSNAT,HPSE,HEXA,IDUA
ko04320	Dorso-ventral axis formation	0.40505912574022	-0.903722233049001	27	11	0.00432559968541093	2543	6908	2885,6655,80315,2114,6654,2120,5604,2113,5594,132864,5595	GRB2,SOS2,CPEB4,ETS2,SOS1,ETV6,MAP2K1,ETS1,MAPK1,CPEB2,MAPK3
hsa04320	Dorso-ventral axis formation	0.40505912574022	-0.903722233049001	27	11	0.00432559968541093	2543	6908	2885,6655,80315,2114,6654,2120,5604,2113,5594,132864,5595	GRB2,SOS2,CPEB4,ETS2,SOS1,ETV6,MAP2K1,ETS1,MAPK1,CPEB2,MAPK3
hsa05164	Influenza A	0.406529916636	-0.900097757041784	174	66	0.0259535981124656	2543	6908	5599,2033,71,5611,5894,7919,5604,9451,3606,3661,3303,5606,1387,3592,5610,7706,3551,5296,51135,8503,103,4940,3459,1386,5970,4599,29107,207,208,842,8743,11100,7416,7297,6773,9021,3305,7514,2932,60,148022,3838,8793,5594,55916,8480,10482,440275,3337,5601,3717,29110,5609,5295,5045,3454,5605,3304,5595,5608,3569,2224,1965,4793,64135,6416	MAPK8,EP300,ACTG1,DNAJC3,RAF1,DDX39B,MAP2K1,EIF2AK3,IL18,IRF3,HSPA1A,MAP2K3,CREBBP,IL12A,EIF2AK2,TRIM25,IKBKB,PIK3R2,IRAK4,PIK3R3,ADAR,OAS3,IFNGR1,ATF2,RELA,MX1,NXT1,AKT1,AKT2,CASP9,TNFSF10,HNRNPUL1,VDAC1,TYK2,STAT2,SOCS3,HSPA1L,XPO1,GSK3B,ACTB,TICAM1,KPNA2,TNFRSF10D,MAPK1,NXT2,RAE1,NXF1,EIF2AK4,DNAJB1,MAPK9,JAK2,TBK1,MAP2K7,PIK3R1,FURIN,IFNAR1,MAP2K2,HSPA1B,MAPK3,MAP2K6,IL6,FDPS,EIF2S1,NFKBIB,IFIH1,MAP2K4
ko05164	Influenza A	0.406529916636	-0.900097757041784	174	66	0.0259535981124656	2543	6908	5599,2033,71,5611,5894,7919,5604,9451,3606,3661,3303,5606,1387,3592,5610,7706,3551,5296,51135,8503,103,4940,3459,1386,5970,4599,29107,207,208,842,8743,11100,7416,7297,6773,9021,3305,7514,2932,60,148022,3838,8793,5594,55916,8480,10482,440275,3337,5601,3717,29110,5609,5295,5045,3454,5605,3304,5595,5608,3569,2224,1965,4793,64135,6416	MAPK8,EP300,ACTG1,DNAJC3,RAF1,DDX39B,MAP2K1,EIF2AK3,IL18,IRF3,HSPA1A,MAP2K3,CREBBP,IL12A,EIF2AK2,TRIM25,IKBKB,PIK3R2,IRAK4,PIK3R3,ADAR,OAS3,IFNGR1,ATF2,RELA,MX1,NXT1,AKT1,AKT2,CASP9,TNFSF10,HNRNPUL1,VDAC1,TYK2,STAT2,SOCS3,HSPA1L,XPO1,GSK3B,ACTB,TICAM1,KPNA2,TNFRSF10D,MAPK1,NXT2,RAE1,NXF1,EIF2AK4,DNAJB1,MAPK9,JAK2,TBK1,MAP2K7,PIK3R1,FURIN,IFNAR1,MAP2K2,HSPA1B,MAPK3,MAP2K6,IL6,FDPS,EIF2S1,NFKBIB,IFIH1,MAP2K4
ko00010	Glycolysis / Gluconeogenesis	0.41176699844017	-0.887297627375989	67	26	0.0102241447109713	2543	6908	5160,5236,2597,55276,2026,669,80201,92579,5315,10327,128,221,5211,230,226,2027,5224,3098,5106,5223,3101,224,7167,5214,3945,223	PDHA1,PGM1,GAPDH,PGM2,ENO2,BPGM,HKDC1,G6PC3,PKM,AKR1A1,ADH5,ALDH3B1,PFKL,ALDOC,ALDOA,ENO3,PGAM2,HK1,PCK2,PGAM1,HK3,ALDH3A2,TPI1,PFKP,LDHB,ALDH9A1
hsa00010	Glycolysis / Gluconeogenesis	0.41176699844017	-0.887297627375989	67	26	0.0102241447109713	2543	6908	5160,5236,2597,2026,55276,669,80201,92579,5315,10327,128,221,5211,230,226,2027,5224,3098,5106,5223,3101,224,5214,7167,3945,223	PDHA1,PGM1,GAPDH,ENO2,PGM2,BPGM,HKDC1,G6PC3,PKM,AKR1A1,ADH5,ALDH3B1,PFKL,ALDOC,ALDOA,ENO3,PGAM2,HK1,PCK2,PGAM1,HK3,ALDH3A2,PFKP,TPI1,LDHB,ALDH9A1
hsa04916	Melanogenesis	0.439490424206061	-0.822139350021316	100	38	0.0149429807314196	2543	6908	2033,8325,5894,5604,808,10488,2535,5566,7474,1387,1499,4157,4286,115,2771,1856,5567,8321,7480,8322,7976,1857,434,7481,2773,5605,8324,6934,5595,2770,2778,817,8326,4254,2932,7855,5594,3265	EP300,FZD8,RAF1,MAP2K1,CALM3,CREB3,FZD2,PRKACA,WNT5A,CREBBP,CTNNB1,MC1R,MITF,ADCY9,GNAI2,DVL2,PRKACB,FZD1,WNT10B,FZD4,FZD3,DVL3,ASIP,WNT11,GNAI3,MAP2K2,FZD7,TCF7L2,MAPK3,GNAI1,GNAS,CAMK2D,FZD9,KITLG,GSK3B,FZD5,MAPK1,HRAS
ko04916	Melanogenesis	0.439490424206061	-0.822139350021316	100	38	0.0149429807314196	2543	6908	2033,8325,5894,5604,808,10488,2535,5566,7474,1387,1499,4157,4286,115,2771,1856,5567,8321,7480,8322,7976,1857,434,7481,2773,5605,8324,6934,5595,2770,2778,817,8326,4254,2932,7855,5594,3265	EP300,FZD8,RAF1,MAP2K1,CALM3,CREB3,FZD2,PRKACA,WNT5A,CREBBP,CTNNB1,MC1R,MITF,ADCY9,GNAI2,DVL2,PRKACB,FZD1,WNT10B,FZD4,FZD3,DVL3,ASIP,WNT11,GNAI3,MAP2K2,FZD7,TCF7L2,MAPK3,GNAI1,GNAS,CAMK2D,FZD9,KITLG,GSK3B,FZD5,MAPK1,HRAS
ko00330	Arginine and proline metabolism	0.440452559189907	-0.819952537044967	49	19	0.00747149036570979	2543	6908	6723,5625,6303,262,112849,4942,4953,5831,8659,2806,8974,65263,1152,5832,55748,112483,224,223,113451	SRM,PRODH,SAT1,AMD1,L3HYPDH,OAT,ODC1,PYCR1,ALDH4A1,GOT2,P4HA2,PYCRL,CKB,ALDH18A1,CNDP2,SAT2,ALDH3A2,ALDH9A1,AZIN2
hsa00330	Arginine and proline metabolism	0.440452559189907	-0.819952537044967	49	19	0.00747149036570979	2543	6908	6723,5625,262,6303,112849,4942,4953,5831,8659,2806,65263,8974,1152,55748,5832,112483,224,113451,223	SRM,PRODH,AMD1,SAT1,L3HYPDH,OAT,ODC1,PYCR1,ALDH4A1,GOT2,PYCRL,P4HA2,CKB,CNDP2,ALDH18A1,SAT2,ALDH3A2,AZIN2,ALDH9A1
hsa00290	Valine, leucine and isoleucine biosynthesis	0.469106611378436	-0.756925219996377	4	2	0.000786472670074715	2543	6908	113675,587	SDSL,BCAT2
ko00290	Valine, leucine and isoleucine biosynthesis	0.469106611378436	-0.756925219996377	4	2	0.000786472670074715	2543	6908	113675,587	SDSL,BCAT2
ko04960	Aldosterone-regulated sodium reabsorption	0.475214328468913	-0.743989358886358	39	15	0.00589854502556036	2543	6908	5170,476,3643,6337,3291,5296,5295,6446,8503,482,481,5594,4306,2810,5595	PDPK1,ATP1A1,INSR,SCNN1A,HSD11B2,PIK3R2,PIK3R1,SGK1,PIK3R3,ATP1B2,ATP1B1,MAPK1,NR3C2,SFN,MAPK3
ko00260	Glycine, serine and threonine metabolism	0.475214328468913	-0.743989358886358	39	15	0.00589854502556036	2543	6908	9380,55349,113675,29968,669,63826,211,6472,5224,5223,2653,5723,132158,2731,1491	GRHPR,CHDH,SDSL,PSAT1,BPGM,SRR,ALAS1,SHMT2,PGAM2,PGAM1,GCSH,PSPH,GLYCTK,GLDC,CTH
hsa00260	Glycine, serine and threonine metabolism	0.475214328468913	-0.743989358886358	39	15	0.00589854502556036	2543	6908	55349,9380,113675,29968,669,63826,211,6472,5224,5223,2653,5723,132158,1491,2731	CHDH,GRHPR,SDSL,PSAT1,BPGM,SRR,ALAS1,SHMT2,PGAM2,PGAM1,GCSH,PSPH,GLYCTK,CTH,GLDC
hsa04960	Aldosterone-regulated sodium reabsorption	0.475214328468913	-0.743989358886358	39	15	0.00589854502556036	2543	6908	5170,476,3643,6337,3291,5296,5295,6446,8503,482,481,5594,4306,2810,5595	PDPK1,ATP1A1,INSR,SCNN1A,HSD11B2,PIK3R2,PIK3R1,SGK1,PIK3R3,ATP1B2,ATP1B1,MAPK1,NR3C2,SFN,MAPK3
hsa05145	Toxoplasmosis	0.492015901257186	-0.709244243383669	118	44	0.0173023987416437	2543	6908	5599,836,1147,598,329,3303,5606,3592,8651,3551,5296,5601,51135,3913,8503,3717,3459,841,2771,6774,5970,3588,10105,5170,330,207,3915,208,5295,842,958,2773,7297,3587,3304,5595,2770,3305,23118,5608,3688,4793,10454,5594	MAPK8,CASP3,CHUK,BCL2L1,BIRC2,HSPA1A,MAP2K3,IL12A,SOCS1,IKBKB,PIK3R2,MAPK9,IRAK4,LAMB2,PIK3R3,JAK2,IFNGR1,CASP8,GNAI2,STAT3,RELA,IL10RB,PPIF,PDPK1,BIRC3,AKT1,LAMC1,AKT2,PIK3R1,CASP9,CD40,GNAI3,TYK2,IL10RA,HSPA1B,MAPK3,GNAI1,HSPA1L,TAB2,MAP2K6,ITGB1,NFKBIB,TAB1,MAPK1
ko05145	Toxoplasmosis	0.492015901257186	-0.709244243383669	118	44	0.0173023987416437	2543	6908	5599,836,1147,598,329,3303,5606,3592,8651,3551,5296,5601,51135,3913,8503,3717,3459,841,2771,6774,5970,3588,10105,5170,330,207,3915,208,5295,842,958,2773,7297,3587,3304,5595,2770,3305,23118,5608,3688,4793,10454,5594	MAPK8,CASP3,CHUK,BCL2L1,BIRC2,HSPA1A,MAP2K3,IL12A,SOCS1,IKBKB,PIK3R2,MAPK9,IRAK4,LAMB2,PIK3R3,JAK2,IFNGR1,CASP8,GNAI2,STAT3,RELA,IL10RB,PPIF,PDPK1,BIRC3,AKT1,LAMC1,AKT2,PIK3R1,CASP9,CD40,GNAI3,TYK2,IL10RA,HSPA1B,MAPK3,GNAI1,HSPA1L,TAB2,MAP2K6,ITGB1,NFKBIB,TAB1,MAPK1
hsa00072	Synthesis and degradation of ketone bodies	0.535066848455012	-0.62536358950858	10	4	0.00157294534014943	2543	6908	38,3155,3157,39	ACAT1,HMGCL,HMGCS1,ACAT2
ko00072	Synthesis and degradation of ketone bodies	0.535066848455012	-0.62536358950858	10	4	0.00157294534014943	2543	6908	38,3155,3157,39	ACAT1,HMGCL,HMGCS1,ACAT2
ko05020	Prion diseases	0.547544635414427	-0.602311294743434	35	13	0.00511207235548565	2543	6908	10963,2534,3915,1958,3569,5604,581,5594,5566,5605,3303,5567,5595	STIP1,FYN,LAMC1,EGR1,IL6,MAP2K1,BAX,MAPK1,PRKACA,MAP2K2,HSPA1A,PRKACB,MAPK3
hsa05020	Prion diseases	0.547544635414427	-0.602311294743434	35	13	0.00511207235548565	2543	6908	10963,2534,3915,1958,3569,5604,581,5594,5566,5605,3303,5567,5595	STIP1,FYN,LAMC1,EGR1,IL6,MAP2K1,BAX,MAPK1,PRKACA,MAP2K2,HSPA1A,PRKACB,MAPK3
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0.54892701976753	-0.599789779337162	24	9	0.00353912701533622	2543	6908	9953,2131,8509,64132,2132,11285,9653,26035,266722	HS3ST3B1,EXT1,NDST2,XYLT2,EXT2,B4GALT7,HS2ST1,GLCE,HS6ST3
hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0.54892701976753	-0.599789779337162	24	9	0.00353912701533622	2543	6908	8509,64132,9953,2131,2132,11285,9653,266722,26035	NDST2,XYLT2,HS3ST3B1,EXT1,EXT2,B4GALT7,HS2ST1,HS6ST3,GLCE
ko04721	Synaptic vesicle cycle	0.56759312596829	-0.566350444466748	63	23	0.00904443570585922	2543	6908	1173,26052,8218,523,535,6616,6857,51382,10312,160,1213,1785,23545,163,527,528,51606,8775,529,1175,9114,8992,9550	AP2M1,DNM3,CLTCL1,ATP6V1A,ATP6V0A1,SNAP25,SYT1,ATP6V1D,TCIRG1,AP2A1,CLTC,DNM2,ATP6V0A2,AP2B1,ATP6V0C,ATP6V1C1,ATP6V1H,NAPA,ATP6V1E1,AP2S1,ATP6V0D1,ATP6V0E1,ATP6V1G1
hsa04721	Synaptic vesicle cycle	0.56759312596829	-0.566350444466748	63	23	0.00904443570585922	2543	6908	1173,26052,8218,523,535,6616,6857,51382,10312,160,1213,1785,23545,163,527,528,51606,8775,529,1175,9114,8992,9550	AP2M1,DNM3,CLTCL1,ATP6V1A,ATP6V0A1,SNAP25,SYT1,ATP6V1D,TCIRG1,AP2A1,CLTC,DNM2,ATP6V0A2,AP2B1,ATP6V0C,ATP6V1C1,ATP6V1H,NAPA,ATP6V1E1,AP2S1,ATP6V0D1,ATP6V0E1,ATP6V1G1
ko05217	Basal cell carcinoma	0.578310894665612	-0.547643674871067	55	20	0.00786472670074715	2543	6908	7480,8322,8325,7976,5727,1857,27148,324,7481,2535,6934,8324,7474,2737,1499,8326,2932,7855,1856,8321	WNT10B,FZD4,FZD8,FZD3,PTCH1,DVL3,STK36,APC,WNT11,FZD2,TCF7L2,FZD7,WNT5A,GLI3,CTNNB1,FZD9,GSK3B,FZD5,DVL2,FZD1
hsa05217	Basal cell carcinoma	0.578310894665612	-0.547643674871067	55	20	0.00786472670074715	2543	6908	7480,8322,8325,7976,5727,1857,27148,324,7481,2535,6934,8324,7474,2737,1499,8326,2932,7855,1856,8321	WNT10B,FZD4,FZD8,FZD3,PTCH1,DVL3,STK36,APC,WNT11,FZD2,TCF7L2,FZD7,WNT5A,GLI3,CTNNB1,FZD9,GSK3B,FZD5,DVL2,FZD1
ko00600	Sphingolipid metabolism	0.591093459541177	-0.525781136106996	47	17	0.00668501769563508	2543	6908	2531,8611,253782,57704,7357,10825,8560,2629,8612,91012,55331,8877,427,2720,2717,56848,9517	KDSR,PLPP1,CERS6,GBA2,UGCG,NEU3,DEGS1,GBA,PLPP2,CERS5,ACER3,SPHK1,ASAH1,GLB1,GLA,SPHK2,SPTLC2
hsa00600	Sphingolipid metabolism	0.591093459541177	-0.525781136106996	47	17	0.00668501769563508	2543	6908	57704,7357,10825,2629,8612,91012,8877,427,55331,9517,2531,8611,253782,8560,2720,2717,56848	GBA2,UGCG,NEU3,GBA,PLPP2,CERS5,SPHK1,ASAH1,ACER3,SPTLC2,KDSR,PLPP1,CERS6,DEGS1,GLB1,GLA,SPHK2
ko04145	Phagosome	0.595043423516936	-0.519120895398736	152	55	0.0216279984270547	2543	6908	3916,1781,7280,71,523,10383,5879,6890,537,821,3693,8411,7037,3105,7057,811,22925,23545,6891,11151,79659,200576,51606,529,9114,10381,55176,9550,83547,7879,23673,9341,3678,535,5868,715,5869,78989,10333,51382,29927,1535,10312,7060,3673,3688,9554,60,527,3685,528,5878,8992,1783,203068	LAMP1,DYNC1I2,TUBB2A,ACTG1,ATP6V1A,TUBB4B,RAC1,TAP1,ATP6AP1,CANX,ITGB5,EEA1,TFRC,HLA-A,THBS1,CALR,PLA2R1,ATP6V0A2,TAP2,CORO1A,DYNC2H1,PIKFYVE,ATP6V1H,ATP6V1E1,ATP6V0D1,TUBB3,SEC61A2,ATP6V1G1,RILP,RAB7A,STX12,VAMP3,ITGA5,ATP6V0A1,RAB5A,C1R,RAB5B,COLEC11,TLR6,ATP6V1D,SEC61A1,CYBA,TCIRG1,THBS4,ITGA2,ITGB1,SEC22B,ACTB,ATP6V0C,ITGAV,ATP6V1C1,RAB5C,ATP6V0E1,DYNC1LI2,TUBB
hsa04145	Phagosome	0.595043423516936	-0.519120895398736	152	55	0.0216279984270547	2543	6908	3916,1781,7280,71,523,10383,5879,6890,537,821,3693,8411,7037,3105,7057,811,22925,23545,6891,11151,79659,200576,51606,529,9114,10381,55176,9550,83547,7879,23673,9341,3678,535,5868,715,5869,78989,10333,51382,29927,1535,10312,7060,3673,3688,9554,60,527,3685,528,5878,8992,1783,203068	LAMP1,DYNC1I2,TUBB2A,ACTG1,ATP6V1A,TUBB4B,RAC1,TAP1,ATP6AP1,CANX,ITGB5,EEA1,TFRC,HLA-A,THBS1,CALR,PLA2R1,ATP6V0A2,TAP2,CORO1A,DYNC2H1,PIKFYVE,ATP6V1H,ATP6V1E1,ATP6V0D1,TUBB3,SEC61A2,ATP6V1G1,RILP,RAB7A,STX12,VAMP3,ITGA5,ATP6V0A1,RAB5A,C1R,RAB5B,COLEC11,TLR6,ATP6V1D,SEC61A1,CYBA,TCIRG1,THBS4,ITGA2,ITGB1,SEC22B,ACTB,ATP6V0C,ITGAV,ATP6V1C1,RAB5C,ATP6V0E1,DYNC1LI2,TUBB
hsa00300	Lysine biosynthesis	0.600766289553885	-0.509549289370901	2	1	0.000393236335037357	2543	6908	51166	AADAT
ko00300	Lysine biosynthesis	0.600766289553885	-0.509549289370901	2	1	0.000393236335037357	2543	6908	51166	AADAT
ko00790	Folate biosynthesis	0.632455311716969	-0.458145714288438	14	5	0.00196618167518679	2543	6908	1719,5805,200895,2356,2643	DHFR,PTS,DHFRL1,FPGS,GCH1
hsa00790	Folate biosynthesis	0.632455311716969	-0.458145714288438	14	5	0.00196618167518679	2543	6908	1719,5805,200895,2356,2643	DHFR,PTS,DHFRL1,FPGS,GCH1
hsa05014	Amyotrophic lateral sclerosis (ALS)	0.640490023072188	-0.445521734547015	51	18	0.00707825403067243	2543	6908	847,836,1616,5608,5879,842,581,5534,5533,5868,5532,317,598,10452,4217,9973,2876,5606	CAT,CASP3,DAXX,MAP2K6,RAC1,CASP9,BAX,PPP3R1,PPP3CC,RAB5A,PPP3CB,APAF1,BCL2L1,TOMM40,MAP3K5,CCS,GPX1,MAP2K3
ko05014	Amyotrophic lateral sclerosis (ALS)	0.640490023072188	-0.445521734547015	51	18	0.00707825403067243	2543	6908	847,836,1616,5608,5879,842,581,5534,5533,5868,5532,317,598,10452,4217,9973,2876,5606	CAT,CASP3,DAXX,MAP2K6,RAC1,CASP9,BAX,PPP3R1,PPP3CC,RAB5A,PPP3CB,APAF1,BCL2L1,TOMM40,MAP3K5,CCS,GPX1,MAP2K3
ko00380	Tryptophan metabolism	0.651663045571053	-0.428227651914679	40	14	0.005505308690523	2543	6908	847,883,39,1962,51166,8942,1892,38,56267,2639,125061,224,1545,223	CAT,CCBL1,ACAT2,EHHADH,AADAT,KYNU,ECHS1,ACAT1,CCBL2,GCDH,AFMID,ALDH3A2,CYP1B1,ALDH9A1
hsa00380	Tryptophan metabolism	0.651663045571053	-0.428227651914679	40	14	0.005505308690523	2543	6908	847,883,39,51166,1962,8942,1892,38,56267,2639,125061,224,223,1545	CAT,CCBL1,ACAT2,AADAT,EHHADH,KYNU,ECHS1,ACAT1,CCBL2,GCDH,AFMID,ALDH3A2,ALDH9A1,CYP1B1
hsa04964	Proximal tubule bicarbonate reclamation	0.655874003036542	-0.42178657702743	23	8	0.00314589068029886	2543	6908	2744,476,8671,1468,4190,482,481,5106	GLS,ATP1A1,SLC4A4,SLC25A10,MDH1,ATP1B2,ATP1B1,PCK2
ko04964	Proximal tubule bicarbonate reclamation	0.655874003036542	-0.42178657702743	23	8	0.00314589068029886	2543	6908	2744,476,8671,1468,4190,482,481,5106	GLS,ATP1A1,SLC4A4,SLC25A10,MDH1,ATP1B2,ATP1B1,PCK2
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	0.660151592987496	-0.415285783990845	74	26	0.0102241447109713	2543	6908	3728,71,1495,59285,3678,5318,87,785,1832,3693,1605,6934,4000,59283,2010,488,1499,783,1829,3673,3688,81,60,784,3685,781	JUP,ACTG1,CTNNA1,CACNG6,ITGA5,PKP2,ACTN1,CACNB4,DSP,ITGB5,DAG1,TCF7L2,LMNA,CACNG8,EMD,ATP2A2,CTNNB1,CACNB2,DSG2,ITGA2,ITGB1,ACTN4,ACTB,CACNB3,ITGAV,CACNA2D1
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	0.660151592987496	-0.415285783990845	74	26	0.0102241447109713	2543	6908	3728,71,1495,59285,3678,5318,87,785,1832,3693,1605,6934,4000,59283,2010,488,1499,783,1829,3673,3688,81,60,784,3685,781	JUP,ACTG1,CTNNA1,CACNG6,ITGA5,PKP2,ACTN1,CACNB4,DSP,ITGB5,DAG1,TCF7L2,LMNA,CACNG8,EMD,ATP2A2,CTNNB1,CACNB2,DSG2,ITGA2,ITGB1,ACTN4,ACTB,CACNB3,ITGAV,CACNA2D1
ko00760	Nicotinate and nicotinamide metabolism	0.669577543542756	-0.40110829749178	29	10	0.00393236335037357	2543	6908	54981,4860,64802,23530,133686,30833,51251,56953,93100,65220	NMRK1,PNP,NMNAT1,NNT,NADK2,NT5C,NT5C3A,NT5M,NAPRT,NADK
hsa00760	Nicotinate and nicotinamide metabolism	0.669577543542756	-0.40110829749178	29	10	0.00393236335037357	2543	6908	54981,64802,4860,23530,133686,30833,51251,56953,93100,65220	NMRK1,NMNAT1,PNP,NNT,NADK2,NT5C,NT5C3A,NT5M,NAPRT,NADK
ko04961	Endocrine and other factor-regulated calcium reabsorption	0.704261883427861	-0.350604998491041	47	16	0.00629178136059772	2543	6908	2778,476,1173,26052,8218,160,1213,115,1785,163,482,481,5566,8766,1175,5567	GNAS,ATP1A1,AP2M1,DNM3,CLTCL1,AP2A1,CLTC,ADCY9,DNM2,AP2B1,ATP1B2,ATP1B1,PRKACA,RAB11A,AP2S1,PRKACB
hsa04961	Endocrine and other factor-regulated calcium reabsorption	0.704261883427861	-0.350604998491041	47	16	0.00629178136059772	2543	6908	2778,476,1173,26052,8218,160,1213,115,1785,163,482,481,5566,8766,1175,5567	GNAS,ATP1A1,AP2M1,DNM3,CLTCL1,AP2A1,CLTC,ADCY9,DNM2,AP2B1,ATP1B2,ATP1B1,PRKACA,RAB11A,AP2S1,PRKACB
hsa00650	Butanoate metabolism	0.712984701969151	-0.338295314661765	27	9	0.00353912701533622	2543	6908	3157,39,1962,65985,1892,38,3155,2571,6296	HMGCS1,ACAT2,EHHADH,AACS,ECHS1,ACAT1,HMGCL,GAD1,ACSM3
ko00650	Butanoate metabolism	0.712984701969151	-0.338295314661765	27	9	0.00353912701533622	2543	6908	3157,39,1962,65985,1892,38,3155,2571,6296	HMGCS1,ACAT2,EHHADH,AACS,ECHS1,ACAT1,HMGCL,GAD1,ACSM3
ko04660	T cell receptor signaling pathway	0.71371436770261	-0.337272441916434	104	36	0.0141565080613449	2543	6908	5894,7410,5604,1147,5532,10298,3551,5062,5296,5601,1739,8503,9020,5970,5170,6655,387,5609,207,6654,4690,208,5777,5295,10892,5605,5595,2885,5335,2534,5534,2932,5533,4793,5594,3265	RAF1,VAV2,MAP2K1,CHUK,PPP3CB,PAK4,IKBKB,PAK2,PIK3R2,MAPK9,DLG1,PIK3R3,MAP3K14,RELA,PDPK1,SOS2,RHOA,MAP2K7,AKT1,SOS1,NCK1,AKT2,PTPN6,PIK3R1,MALT1,MAP2K2,MAPK3,GRB2,PLCG1,FYN,PPP3R1,GSK3B,PPP3CC,NFKBIB,MAPK1,HRAS
hsa04660	T cell receptor signaling pathway	0.71371436770261	-0.337272441916434	104	36	0.0141565080613449	2543	6908	5894,7410,5604,1147,5532,10298,3551,5062,5296,5601,1739,8503,9020,5970,5170,6655,387,5609,207,6654,4690,208,5777,5295,10892,5605,5595,2885,5335,2534,5534,2932,5533,4793,5594,3265	RAF1,VAV2,MAP2K1,CHUK,PPP3CB,PAK4,IKBKB,PAK2,PIK3R2,MAPK9,DLG1,PIK3R3,MAP3K14,RELA,PDPK1,SOS2,RHOA,MAP2K7,AKT1,SOS1,NCK1,AKT2,PTPN6,PIK3R1,MALT1,MAP2K2,MAPK3,GRB2,PLCG1,FYN,PPP3R1,GSK3B,PPP3CC,NFKBIB,MAPK1,HRAS
hsa04530	Tight junction	0.720179830110451	-0.328254334115589	138	48	0.0188753440817932	2543	6908	10398,9076,55870,154810,71,1495,5520,22808,50848,64398,7082,4628,84612,5519,5581,1499,3993,3996,5584,2017,5521,8531,22800,2771,4636,1366,6709,387,8573,207,6237,5872,137075,208,87,7525,2773,260425,93643,2770,10207,2035,60412,5590,81,60,9223,3265	MYL9,CLDN1,ASH1L,AMOTL1,ACTG1,CTNNA1,PPP2R2A,MRAS,F11R,MPP5,TJP1,MYH10,PARD6B,PPP2R1B,PRKCE,CTNNB1,LLGL2,LLGL1,PRKCI,CTTN,PPP2R2B,YBX3,RRAS2,GNAI2,MYL5,CLDN7,SPTAN1,RHOA,CASK,AKT1,RRAS,RAB13,CLDN23,AKT2,ACTN1,YES1,GNAI3,MAGI3,TJAP1,GNAI1,INADL,EPB41,EXOC4,PRKCZ,ACTN4,ACTB,MAGI1,HRAS
ko04530	Tight junction	0.720179830110451	-0.328254334115589	138	48	0.0188753440817932	2543	6908	10398,9076,55870,154810,71,1495,5520,22808,50848,64398,7082,4628,84612,5519,5581,1499,3993,3996,5584,2017,5521,8531,22800,2771,4636,1366,6709,387,8573,207,6237,5872,137075,208,87,7525,2773,260425,93643,2770,10207,2035,60412,5590,81,60,9223,3265	MYL9,CLDN1,ASH1L,AMOTL1,ACTG1,CTNNA1,PPP2R2A,MRAS,F11R,MPP5,TJP1,MYH10,PARD6B,PPP2R1B,PRKCE,CTNNB1,LLGL2,LLGL1,PRKCI,CTTN,PPP2R2B,YBX3,RRAS2,GNAI2,MYL5,CLDN7,SPTAN1,RHOA,CASK,AKT1,RRAS,RAB13,CLDN23,AKT2,ACTN1,YES1,GNAI3,MAGI3,TJAP1,GNAI1,INADL,EPB41,EXOC4,PRKCZ,ACTN4,ACTB,MAGI1,HRAS
hsa04611	Platelet activation	0.729414093739591	-0.315513678420238	130	45	0.0176956350766811	2543	6908	4659,71,8673,2812,3709,5566,4067,5501,5906,7408,6786,5296,115,9138,1289,5584,8503,84876,5499,2771,9475,5567,387,207,208,5295,6916,5908,23365,3710,2773,5595,2770,2778,2534,8773,3708,3673,3688,5590,5500,60,6093,5594,10672	PPP1R12A,ACTG1,VAMP8,GP1BB,ITPR2,PRKACA,LYN,PPP1CC,RAP1A,VASP,STIM1,PIK3R2,ADCY9,ARHGEF1,COL5A1,PRKCI,PIK3R3,ORAI1,PPP1CA,GNAI2,ROCK2,PRKACB,RHOA,AKT1,AKT2,PIK3R1,TBXAS1,RAP1B,ARHGEF12,ITPR3,GNAI3,MAPK3,GNAI1,GNAS,FYN,SNAP23,ITPR1,ITGA2,ITGB1,PRKCZ,PPP1CB,ACTB,ROCK1,MAPK1,GNA13
ko04912	GnRH signaling pathway	0.742319237512208	-0.297975889106336	91	31	0.0121903263861581	2543	6908	4215,5599,6655,468,5609,6654,5894,5604,808,3709,3710,5566,5605,2767,5606,5595,2885,2778,817,5608,5601,3708,115,2185,5337,5598,5594,3265,6416,5567,4214	MAP3K3,MAPK8,SOS2,ATF4,MAP2K7,SOS1,RAF1,MAP2K1,CALM3,ITPR2,ITPR3,PRKACA,MAP2K2,GNA11,MAP2K3,MAPK3,GRB2,GNAS,CAMK2D,MAP2K6,MAPK9,ITPR1,ADCY9,PTK2B,PLD1,MAPK7,MAPK1,HRAS,MAP2K4,PRKACB,MAP3K1
hsa04912	GnRH signaling pathway	0.742319237512208	-0.297975889106336	91	31	0.0121903263861581	2543	6908	4215,5599,6655,468,5609,6654,5894,5604,808,3709,3710,5566,5605,2767,5606,5595,2885,2778,817,5608,5601,3708,115,2185,5337,5598,5594,3265,6416,5567,4214	MAP3K3,MAPK8,SOS2,ATF4,MAP2K7,SOS1,RAF1,MAP2K1,CALM3,ITPR2,ITPR3,PRKACA,MAP2K2,GNA11,MAP2K3,MAPK3,GRB2,GNAS,CAMK2D,MAP2K6,MAPK9,ITPR1,ADCY9,PTK2B,PLD1,MAPK7,MAPK1,HRAS,MAP2K4,PRKACB,MAP3K1
hsa00780	Biotin metabolism	0.747776328024317	-0.290651372430518	3	1	0.000393236335037357	2543	6908	686	BTD
ko00780	Biotin metabolism	0.747776328024317	-0.290651372430518	3	1	0.000393236335037357	2543	6908	686	BTD
hsa04510	Focal adhesion	0.753206987362352	-0.283415205340481	207	72	0.0283130161226897	2543	6908	10398,5599,71,5894,5879,5604,2064,329,5881,1399,7791,5906,1499,6464,5296,1289,54776,8503,5499,7414,4636,6655,207,330,208,87,857,7422,2534,1398,3673,3688,81,2932,5500,60,6093,5594,673,4659,7410,3693,5501,10298,7057,824,7408,5601,896,5062,1291,3913,9475,7423,5170,387,3915,6654,5295,5908,3678,5747,9564,1729,5595,2885,29780,7060,4660,3685,1288,3265	MYL9,MAPK8,ACTG1,RAF1,RAC1,MAP2K1,ERBB2,BIRC2,RAC3,CRKL,ZYX,RAP1A,CTNNB1,SHC1,PIK3R2,COL5A1,PPP1R12C,PIK3R3,PPP1CA,VCL,MYL5,SOS2,AKT1,BIRC3,AKT2,ACTN1,CAV1,VEGFA,FYN,CRK,ITGA2,ITGB1,ACTN4,GSK3B,PPP1CB,ACTB,ROCK1,MAPK1,BRAF,PPP1R12A,VAV2,ITGB5,PPP1CC,PAK4,THBS1,CAPN2,VASP,MAPK9,CCND3,PAK2,COL6A1,LAMB2,ROCK2,VEGFB,PDPK1,RHOA,LAMC1,SOS1,PIK3R1,RAP1B,ITGA5,PTK2,BCAR1,DIAPH1,MAPK3,GRB2,PARVB,THBS4,PPP1R12B,ITGAV,COL4A6,HRAS
ko04510	Focal adhesion	0.753206987362352	-0.283415205340481	207	72	0.0283130161226897	2543	6908	10398,5599,71,5894,5879,5604,2064,329,5881,1399,7791,5906,1499,6464,5296,1289,54776,8503,5499,7414,4636,6655,207,330,208,87,857,7422,2534,1398,3673,3688,81,2932,5500,60,6093,5594,673,4659,7410,3693,5501,10298,7057,824,7408,5601,896,5062,1291,3913,9475,7423,5170,387,3915,6654,5295,5908,3678,5747,9564,1729,5595,2885,29780,7060,4660,3685,1288,3265	MYL9,MAPK8,ACTG1,RAF1,RAC1,MAP2K1,ERBB2,BIRC2,RAC3,CRKL,ZYX,RAP1A,CTNNB1,SHC1,PIK3R2,COL5A1,PPP1R12C,PIK3R3,PPP1CA,VCL,MYL5,SOS2,AKT1,BIRC3,AKT2,ACTN1,CAV1,VEGFA,FYN,CRK,ITGA2,ITGB1,ACTN4,GSK3B,PPP1CB,ACTB,ROCK1,MAPK1,BRAF,PPP1R12A,VAV2,ITGB5,PPP1CC,PAK4,THBS1,CAPN2,VASP,MAPK9,CCND3,PAK2,COL6A1,LAMB2,ROCK2,VEGFB,PDPK1,RHOA,LAMC1,SOS1,PIK3R1,RAP1B,ITGA5,PTK2,BCAR1,DIAPH1,MAPK3,GRB2,PARVB,THBS4,PPP1R12B,ITGAV,COL4A6,HRAS
ko05162	Measles	0.754365916002144	-0.281877728956422	134	46	0.0180888714117184	2543	6908	9451,1147,6777,3661,440275,3303,898,3592,6869,5610,896,5296,51135,1027,8503,3717,103,4940,3459,6774,5970,1021,4599,29110,207,7128,208,5295,8743,10399,3454,7297,6773,8667,3304,3305,2534,23118,3569,2932,1965,6776,8793,4793,64135,9367	EIF2AK3,CHUK,STAT5B,IRF3,EIF2AK4,HSPA1A,CCNE1,IL12A,TACR1,EIF2AK2,CCND3,PIK3R2,IRAK4,CDKN1B,PIK3R3,JAK2,ADAR,OAS3,IFNGR1,STAT3,RELA,CDK6,MX1,TBK1,AKT1,TNFAIP3,AKT2,PIK3R1,TNFSF10,GNB2L1,IFNAR1,TYK2,STAT2,EIF3H,HSPA1B,HSPA1L,FYN,TAB2,IL6,GSK3B,EIF2S1,STAT5A,TNFRSF10D,NFKBIB,IFIH1,RAB9A
hsa05162	Measles	0.754365916002144	-0.281877728956422	134	46	0.0180888714117184	2543	6908	9451,1147,6777,3661,440275,3303,898,3592,6869,5610,896,5296,51135,1027,8503,3717,103,4940,3459,6774,5970,1021,4599,29110,207,7128,208,5295,8743,10399,3454,7297,6773,8667,3304,3305,2534,23118,3569,2932,1965,6776,8793,4793,64135,9367	EIF2AK3,CHUK,STAT5B,IRF3,EIF2AK4,HSPA1A,CCNE1,IL12A,TACR1,EIF2AK2,CCND3,PIK3R2,IRAK4,CDKN1B,PIK3R3,JAK2,ADAR,OAS3,IFNGR1,STAT3,RELA,CDK6,MX1,TBK1,AKT1,TNFAIP3,AKT2,PIK3R1,TNFSF10,GNB2L1,IFNAR1,TYK2,STAT2,EIF3H,HSPA1B,HSPA1L,FYN,TAB2,IL6,GSK3B,EIF2S1,STAT5A,TNFRSF10D,NFKBIB,IFIH1,RAB9A
hsa04730	Long-term depression	0.754598383844423	-0.28156961319233	60	20	0.00786472670074715	2543	6908	673,5894,5604,3709,3710,4067,2773,5605,2767,5519,5595,2770,2778,2768,2781,3708,5594,2771,10672,3265	BRAF,RAF1,MAP2K1,ITPR2,ITPR3,LYN,GNAI3,MAP2K2,GNA11,PPP2R1B,MAPK3,GNAI1,GNAS,GNA12,GNAZ,ITPR1,MAPK1,GNAI2,GNA13,HRAS
ko04730	Long-term depression	0.754598383844423	-0.28156961319233	60	20	0.00786472670074715	2543	6908	673,5894,5604,3709,3710,4067,2773,5605,2767,5519,5595,2770,2778,2768,2781,3708,5594,2771,10672,3265	BRAF,RAF1,MAP2K1,ITPR2,ITPR3,LYN,GNAI3,MAP2K2,GNA11,PPP2R1B,MAPK3,GNAI1,GNAS,GNA12,GNAZ,ITPR1,MAPK1,GNAI2,GNA13,HRAS
ko00410	beta-Alanine metabolism	0.759383674529456	-0.275248129269802	31	10	0.00393236335037357	2543	6908	6723,221,1962,4329,1892,1806,55748,2571,224,223	SRM,ALDH3B1,EHHADH,ALDH6A1,ECHS1,DPYD,CNDP2,GAD1,ALDH3A2,ALDH9A1
hsa00410	beta-Alanine metabolism	0.759383674529456	-0.275248129269802	31	10	0.00393236335037357	2543	6908	6723,221,1962,4329,1892,1806,55748,2571,224,223	SRM,ALDH3B1,EHHADH,ALDH6A1,ECHS1,DPYD,CNDP2,GAD1,ALDH3A2,ALDH9A1
ko05133	Pertussis	0.771418979049451	-0.259523630127922	75	25	0.00983090837593394	2543	6908	5599,836,387,3678,808,715,3661,2773,1073,5595,2770,3592,840,10392,3569,51135,5601,3688,148022,717,2771,5970,5594,3659,114609	MAPK8,CASP3,RHOA,ITGA5,CALM3,C1R,IRF3,GNAI3,CFL2,MAPK3,GNAI1,IL12A,CASP7,NOD1,IL6,IRAK4,MAPK9,ITGB1,TICAM1,C2,GNAI2,RELA,MAPK1,IRF1,TIRAP
hsa05133	Pertussis	0.771418979049451	-0.259523630127922	75	25	0.00983090837593394	2543	6908	5599,836,387,3678,808,715,3661,2773,1073,5595,2770,3592,840,10392,3569,51135,5601,3688,148022,717,2771,5970,5594,3659,114609	MAPK8,CASP3,RHOA,ITGA5,CALM3,C1R,IRF3,GNAI3,CFL2,MAPK3,GNAI1,IL12A,CASP7,NOD1,IL6,IRAK4,MAPK9,ITGB1,TICAM1,C2,GNAI2,RELA,MAPK1,IRF1,TIRAP
ko05160	Hepatitis C	0.790155935344706	-0.235524966486939	133	45	0.0176956350766811	2543	6908	9076,5599,673,5894,7186,6256,9451,5520,3646,1147,3661,440275,1026,5519,5610,3551,5296,5601,8503,5521,4940,6774,5970,1366,5170,6655,29110,207,137075,6654,208,5295,5465,3454,7297,6773,5595,9021,2885,1965,2932,148022,5594,3265,3659	CLDN1,MAPK8,BRAF,RAF1,TRAF2,RXRA,EIF2AK3,PPP2R2A,EIF3E,CHUK,IRF3,EIF2AK4,CDKN1A,PPP2R1B,EIF2AK2,IKBKB,PIK3R2,MAPK9,PIK3R3,PPP2R2B,OAS3,STAT3,RELA,CLDN7,PDPK1,SOS2,TBK1,AKT1,CLDN23,SOS1,AKT2,PIK3R1,PPARA,IFNAR1,TYK2,STAT2,MAPK3,SOCS3,GRB2,EIF2S1,GSK3B,TICAM1,MAPK1,HRAS,IRF1
hsa05160	Hepatitis C	0.790155935344706	-0.235524966486939	133	45	0.0176956350766811	2543	6908	9076,5599,673,5894,7186,6256,9451,5520,3646,1147,3661,440275,1026,5519,5610,3551,5296,5601,8503,5521,4940,6774,5970,1366,5170,6655,29110,207,137075,6654,208,5295,5465,3454,7297,6773,5595,9021,2885,1965,2932,148022,5594,3265,3659	CLDN1,MAPK8,BRAF,RAF1,TRAF2,RXRA,EIF2AK3,PPP2R2A,EIF3E,CHUK,IRF3,EIF2AK4,CDKN1A,PPP2R1B,EIF2AK2,IKBKB,PIK3R2,MAPK9,PIK3R3,PPP2R2B,OAS3,STAT3,RELA,CLDN7,PDPK1,SOS2,TBK1,AKT1,CLDN23,SOS1,AKT2,PIK3R1,PPARA,IFNAR1,TYK2,STAT2,MAPK3,SOCS3,GRB2,EIF2S1,GSK3B,TICAM1,MAPK1,HRAS,IRF1
hsa04014	Ras signaling pathway	0.80147692981223	-0.221299091111943	227	78	0.0306724341329139	2543	6908	5599,9462,4763,2785,5894,10928,5879,5604,2782,1147,22808,598,11145,5566,2783,5881,5906,6464,5899,3551,5296,8503,55770,5970,5567,6655,207,208,2257,283455,83593,5868,7422,5869,2260,5898,5335,1969,1945,59345,4254,5863,382,5594,2549,5966,5900,808,11186,81579,2113,10298,25,10681,5601,5062,5781,22800,8398,7423,387,29110,6237,4303,6654,5295,5908,8437,5605,5921,5595,2885,3643,2114,5337,3265,5878,6789	MAPK8,RASAL2,NF1,GNG3,RAF1,RALBP1,RAC1,MAP2K1,GNB1,CHUK,MRAS,BCL2L1,PLA2G16,PRKACA,GNB2,RAC3,RAP1A,SHC1,RALB,IKBKB,PIK3R2,PIK3R3,EXOC2,RELA,PRKACB,SOS2,AKT1,AKT2,FGF12,KSR2,RASSF5,RAB5A,VEGFA,RAB5B,FGFR1,RALA,PLCG1,EPHA2,EFNA4,GNB4,KITLG,RGL2,ARF6,MAPK1,GAB1,REL,RALGDS,CALM3,RASSF1,PLA2G12A,ETS1,PAK4,ABL1,GNB5,MAPK9,PAK2,PTPN11,RRAS2,PLA2G6,VEGFB,RHOA,TBK1,RRAS,FOXO4,SOS1,PIK3R1,RAP1B,RASAL1,MAP2K2,RASA1,MAPK3,GRB2,INSR,ETS2,PLD1,HRAS,RAB5C,STK4
ko00220	Arginine biosynthesis	0.804630865050378	-0.217371659463478	20	6	0.00235941801022414	2543	6908	84706,2744,1373,2806,2752,435	GPT2,GLS,CPS1,GOT2,GLUL,ASL
hsa00220	Arginine biosynthesis	0.804630865050378	-0.217371659463478	20	6	0.00235941801022414	2543	6908	84706,2744,1373,2806,2752,435	GPT2,GLS,CPS1,GOT2,GLUL,ASL
hsa04923	Regulation of lipolysis in adipocytes	0.806000943591471	-0.215670365767173	56	18	0.00707825403067243	2543	6908	207,208,5295,4881,154,11145,2773,5566,2770,2778,8660,5743,3643,115,5296,8503,2771,5567	AKT1,AKT2,PIK3R1,NPR1,ADRB2,PLA2G16,GNAI3,PRKACA,GNAI1,GNAS,IRS2,PTGS2,INSR,ADCY9,PIK3R2,PIK3R3,GNAI2,PRKACB
ko00120	Primary bile acid biosynthesis	0.810274458242925	-0.210382251371114	17	5	0.00196618167518679	2543	6908	6342,3295,51302,10858,10005	SCP2,HSD17B4,CYP39A1,CYP46A1,ACOT8
hsa00120	Primary bile acid biosynthesis	0.810274458242925	-0.210382251371114	17	5	0.00196618167518679	2543	6908	6342,3295,51302,10858,10005	SCP2,HSD17B4,CYP39A1,CYP46A1,ACOT8
hsa00562	Inositol phosphate metabolism	0.815229652884624	-0.204285422754037	71	23	0.00904443570585922	2543	6908	3612,3636,4329,79837,5297,51477,10423,8394,8898,55361,8396,5335,64768,5298,9110,4952,54928,253430,138429,200576,3706,7167,3613	IMPA1,INPPL1,ALDH6A1,PIP4K2C,PI4KA,ISYNA1,CDIPT,PIP5K1A,MTMR2,PI4K2A,PIP4K2B,PLCG1,IPPK,PI4KB,MTMR4,OCRL,IMPAD1,IPMK,PIP5KL1,PIKFYVE,ITPKA,TPI1,IMPA2
ko00562	Inositol phosphate metabolism	0.815229652884624	-0.204285422754037	71	23	0.00904443570585922	2543	6908	3612,3636,4329,79837,5297,51477,8394,10423,8898,55361,5335,8396,64768,5298,9110,54928,4952,253430,138429,3706,200576,3613,7167	IMPA1,INPPL1,ALDH6A1,PIP4K2C,PI4KA,ISYNA1,PIP5K1A,CDIPT,MTMR2,PI4K2A,PLCG1,PIP4K2B,IPPK,PI4KB,MTMR4,IMPAD1,OCRL,IPMK,PIP5KL1,ITPKA,PIKFYVE,IMPA2,TPI1
hsa00603	Glycosphingolipid biosynthesis - globo series	0.819071139818039	-0.199584337096648	14	4	0.00157294534014943	2543	6908	2717,6482,3073,4668	GLA,ST3GAL1,HEXA,NAGA
ko00603	Glycosphingolipid biosynthesis - globo series	0.819071139818039	-0.199584337096648	14	4	0.00157294534014943	2543	6908	2717,6482,3073,4668	GLA,ST3GAL1,HEXA,NAGA
ko04140	Regulation of autophagy	0.828860996814128	-0.187702813642868	39	12	0.00471883602044829	2543	6908	84938,22863,89849,11337,5562,30849,9140,8408,9474,23192,8678,84971	ATG4C,ATG14,ATG16L2,GABARAP,PRKAA1,PIK3R4,ATG12,ULK1,ATG5,ATG4B,BECN1,ATG4D
hsa04140	Regulation of autophagy	0.828860996814128	-0.187702813642868	39	12	0.00471883602044829	2543	6908	84938,22863,89849,11337,5562,30849,9140,8408,9474,23192,8678,84971	ATG4C,ATG14,ATG16L2,GABARAP,PRKAA1,PIK3R4,ATG12,ULK1,ATG5,ATG4B,BECN1,ATG4D
ko04670	Leukocyte transendothelial migration	0.828946875560123	-0.187599208457367	118	39	0.0153362170664569	2543	6908	10398,9076,71,1495,5879,7410,50848,90952,7408,5906,1499,5296,5781,8503,7414,2771,4636,9475,1366,387,137075,5295,5908,83593,7430,87,5747,9564,2773,2770,5335,7852,1535,3688,2185,81,1500,60,6093	MYL9,CLDN1,ACTG1,CTNNA1,RAC1,VAV2,F11R,ESAM,VASP,RAP1A,CTNNB1,PIK3R2,PTPN11,PIK3R3,VCL,GNAI2,MYL5,ROCK2,CLDN7,RHOA,CLDN23,PIK3R1,RAP1B,RASSF5,EZR,ACTN1,PTK2,BCAR1,GNAI3,GNAI1,PLCG1,CXCR4,CYBA,ITGB1,PTK2B,ACTN4,CTNND1,ACTB,ROCK1
hsa04670	Leukocyte transendothelial migration	0.828946875560123	-0.187599208457367	118	39	0.0153362170664569	2543	6908	10398,9076,71,1495,5879,7410,50848,90952,7408,5906,1499,5296,5781,8503,7414,2771,4636,9475,1366,387,137075,5295,5908,83593,7430,87,5747,9564,2773,2770,5335,7852,1535,3688,2185,81,1500,60,6093	MYL9,CLDN1,ACTG1,CTNNA1,RAC1,VAV2,F11R,ESAM,VASP,RAP1A,CTNNB1,PIK3R2,PTPN11,PIK3R3,VCL,GNAI2,MYL5,ROCK2,CLDN7,RHOA,CLDN23,PIK3R1,RAP1B,RASSF5,EZR,ACTN1,PTK2,BCAR1,GNAI3,GNAI1,PLCG1,CXCR4,CYBA,ITGB1,PTK2B,ACTN4,CTNND1,ACTB,ROCK1
hsa04340	Hedgehog signaling pathway	0.829701371629642	-0.186689436149901	51	16	0.00629178136059772	2543	6908	23291,2737,7480,1454,51715,5727,2932,7546,27148,7481,1452,5566,1456,5567,2619,7474	FBXW11,GLI3,WNT10B,CSNK1E,RAB23,PTCH1,GSK3B,ZIC2,STK36,WNT11,CSNK1A1,PRKACA,CSNK1G3,PRKACB,GAS1,WNT5A
ko04340	Hedgehog signaling pathway	0.829701371629642	-0.186689436149901	51	16	0.00629178136059772	2543	6908	23291,2737,7480,1454,51715,5727,2932,7546,27148,7481,1452,5566,1456,5567,2619,7474	FBXW11,GLI3,WNT10B,CSNK1E,RAB23,PTCH1,GSK3B,ZIC2,STK36,WNT11,CSNK1A1,PRKACA,CSNK1G3,PRKACB,GAS1,WNT5A
ko00130	Ubiquinone and other terpenoid-quinone biosynthesis	0.833024534388061	-0.182692184202134	11	3	0.00117970900511207	2543	6908	2677,84274,51805	GGCX,COQ5,COQ3
hsa00430	Taurine and hypotaurine metabolism	0.833024534388061	-0.182692184202134	11	3	0.00117970900511207	2543	6908	51380,2571,84890	CSAD,GAD1,ADO
hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	0.833024534388061	-0.182692184202134	11	3	0.00117970900511207	2543	6908	2677,84274,51805	GGCX,COQ5,COQ3
ko00430	Taurine and hypotaurine metabolism	0.833024534388061	-0.182692184202134	11	3	0.00117970900511207	2543	6908	51380,2571,84890	CSAD,GAD1,ADO
ko00740	Riboflavin metabolism	0.840666233579413	-0.173560566296713	4	1	0.000393236335037357	2543	6908	80308	FLAD1
ko00471	D-Glutamine and D-glutamate metabolism	0.840666233579413	-0.173560566296713	4	1	0.000393236335037357	2543	6908	2744	GLS
hsa00471	D-Glutamine and D-glutamate metabolism	0.840666233579413	-0.173560566296713	4	1	0.000393236335037357	2543	6908	2744	GLS
hsa00740	Riboflavin metabolism	0.840666233579413	-0.173560566296713	4	1	0.000393236335037357	2543	6908	80308	FLAD1
ko04261	Adrenergic signaling in cardiomyocytes	0.848789873925341	-0.163943621624707	148	49	0.0192685804168305	2543	6908	1388,59285,5520,808,10488,785,5566,9252,5501,5519,1390,59283,488,6324,783,5296,115,8503,6548,5499,5521,2771,1386,5567,468,7170,207,7169,208,5295,7171,154,481,2773,5595,2770,2778,817,5529,476,5500,5527,482,784,7168,5594,5528,781,493	ATF6B,CACNG6,PPP2R2A,CALM3,CREB3,CACNB4,PRKACA,RPS6KA5,PPP1CC,PPP2R1B,CREM,CACNG8,ATP2A2,SCN1B,CACNB2,PIK3R2,ADCY9,PIK3R3,SLC9A1,PPP1CA,PPP2R2B,GNAI2,ATF2,PRKACB,ATF4,TPM3,AKT1,TPM2,AKT2,PIK3R1,TPM4,ADRB2,ATP1B1,GNAI3,MAPK3,GNAI1,GNAS,CAMK2D,PPP2R5E,ATP1A1,PPP1CB,PPP2R5C,ATP1B2,CACNB3,TPM1,MAPK1,PPP2R5D,CACNA2D1,ATP2B4
hsa04261	Adrenergic signaling in cardiomyocytes	0.848789873925341	-0.163943621624707	148	49	0.0192685804168305	2543	6908	1388,59285,5520,808,10488,785,5566,9252,5501,5519,1390,59283,488,6324,783,5296,115,8503,6548,5499,5521,2771,1386,5567,468,7170,207,7169,208,5295,7171,154,481,2773,5595,2770,2778,817,5529,476,5500,5527,482,784,7168,5594,5528,781,493	ATF6B,CACNG6,PPP2R2A,CALM3,CREB3,CACNB4,PRKACA,RPS6KA5,PPP1CC,PPP2R1B,CREM,CACNG8,ATP2A2,SCN1B,CACNB2,PIK3R2,ADCY9,PIK3R3,SLC9A1,PPP1CA,PPP2R2B,GNAI2,ATF2,PRKACB,ATF4,TPM3,AKT1,TPM2,AKT2,PIK3R1,TPM4,ADRB2,ATP1B1,GNAI3,MAPK3,GNAI1,GNAS,CAMK2D,PPP2R5E,ATP1A1,PPP1CB,PPP2R5C,ATP1B2,CACNB3,TPM1,MAPK1,PPP2R5D,CACNA2D1,ATP2B4
hsa04622	RIG-I-like receptor signaling pathway	0.85656493462578	-0.15482515016784	70	22	0.00865119937082186	2543	6908	55593,5599,29110,7186,9140,80143,1147,3661,64343,9636,1654,3592,7706,10010,5601,3551,4793,841,9474,5970,64135,4214	OTUD5,MAPK8,TBK1,TRAF2,ATG12,SIKE1,CHUK,IRF3,AZI2,ISG15,DDX3X,IL12A,TRIM25,TANK,MAPK9,IKBKB,NFKBIB,CASP8,ATG5,RELA,IFIH1,MAP3K1
ko04622	RIG-I-like receptor signaling pathway	0.85656493462578	-0.15482515016784	70	22	0.00865119937082186	2543	6908	55593,5599,29110,7186,9140,80143,1147,3661,64343,9636,1654,3592,7706,10010,5601,3551,4793,841,9474,5970,64135,4214	OTUD5,MAPK8,TBK1,TRAF2,ATG12,SIKE1,CHUK,IRF3,AZI2,ISG15,DDX3X,IL12A,TRIM25,TANK,MAPK9,IKBKB,NFKBIB,CASP8,ATG5,RELA,IFIH1,MAP3K1
hsa04540	Gap junction	0.862362397287207	-0.148079682181534	88	28	0.011010617381046	2543	6908	6655,7280,5607,6654,10383,5894,5604,7082,3709,3710,5566,2773,983,5605,2767,5595,2770,2885,2778,3708,115,5598,5594,2771,3265,5567,203068,10381	SOS2,TUBB2A,MAP2K5,SOS1,TUBB4B,RAF1,MAP2K1,TJP1,ITPR2,ITPR3,PRKACA,GNAI3,CDK1,MAP2K2,GNA11,MAPK3,GNAI1,GRB2,GNAS,ITPR1,ADCY9,MAPK7,MAPK1,GNAI2,HRAS,PRKACB,TUBB,TUBB3
ko04540	Gap junction	0.862362397287207	-0.148079682181534	88	28	0.011010617381046	2543	6908	6655,7280,5607,6654,10383,5894,5604,7082,3709,3710,5566,2773,983,5605,2767,5595,2770,2885,2778,3708,115,5598,5594,2771,3265,5567,203068,10381	SOS2,TUBB2A,MAP2K5,SOS1,TUBB4B,RAF1,MAP2K1,TJP1,ITPR2,ITPR3,PRKACA,GNAI3,CDK1,MAP2K2,GNA11,MAPK3,GNAI1,GRB2,GNAS,ITPR1,ADCY9,MAPK7,MAPK1,GNAI2,HRAS,PRKACB,TUBB,TUBB3
hsa04064	NF-kappa B signaling pathway	0.863470158205801	-0.146795941105726	91	29	0.0114038537160834	2543	6908	51588,55367,7128,330,115650,257397,7186,10892,1147,2920,598,958,4067,329,23085,5335,5743,7185,23118,7706,4616,3551,51135,148022,9020,4791,10454,5970,114609	PIAS4,PIDD1,TNFAIP3,BIRC3,TNFRSF13C,TAB3,TRAF2,MALT1,CHUK,CXCL2,BCL2L1,CD40,LYN,BIRC2,ERC1,PLCG1,PTGS2,TRAF1,TAB2,TRIM25,GADD45B,IKBKB,IRAK4,TICAM1,MAP3K14,NFKB2,TAB1,RELA,TIRAP
ko05410	Hypertrophic cardiomyopathy (HCM)	0.877228952498941	-0.130987257398328	83	26	0.0102241447109713	2543	6908	7169,7170,71,5565,5562,7171,59285,3678,5571,785,3693,1605,4000,59283,51422,2010,488,783,3569,3673,3688,60,784,3685,7168,781	TPM2,TPM3,ACTG1,PRKAB2,PRKAA1,TPM4,CACNG6,ITGA5,PRKAG1,CACNB4,ITGB5,DAG1,LMNA,CACNG8,PRKAG2,EMD,ATP2A2,CACNB2,IL6,ITGA2,ITGB1,ACTB,CACNB3,ITGAV,TPM1,CACNA2D1
hsa05410	Hypertrophic cardiomyopathy (HCM)	0.877228952498941	-0.130987257398328	83	26	0.0102241447109713	2543	6908	7169,7170,71,5565,5562,7171,59285,3678,5571,785,3693,1605,4000,59283,51422,2010,488,783,3569,3673,3688,60,784,3685,7168,781	TPM2,TPM3,ACTG1,PRKAB2,PRKAA1,TPM4,CACNG6,ITGA5,PRKAG1,CACNB4,ITGB5,DAG1,LMNA,CACNG8,PRKAG2,EMD,ATP2A2,CACNB2,IL6,ITGA2,ITGB1,ACTB,CACNB3,ITGAV,TPM1,CACNA2D1
hsa04380	Osteoclast differentiation	0.891477169406223	-0.114875451197863	131	42	0.016515926071569	2543	6908	5599,7186,5879,5604,814,1147,5532,2355,3727,8878,8651,3551,5296,5601,4286,3726,2354,8503,9020,3459,4791,5970,5609,207,5468,208,5295,2274,3454,7297,6773,5595,9021,2885,2534,1535,23118,5608,5534,5533,10454,5594	MAPK8,TRAF2,RAC1,MAP2K1,CAMK4,CHUK,PPP3CB,FOSL2,JUND,SQSTM1,SOCS1,IKBKB,PIK3R2,MAPK9,MITF,JUNB,FOSB,PIK3R3,MAP3K14,IFNGR1,NFKB2,RELA,MAP2K7,AKT1,PPARG,AKT2,PIK3R1,FHL2,IFNAR1,TYK2,STAT2,MAPK3,SOCS3,GRB2,FYN,CYBA,TAB2,MAP2K6,PPP3R1,PPP3CC,TAB1,MAPK1
ko04380	Osteoclast differentiation	0.891477169406223	-0.114875451197863	131	42	0.016515926071569	2543	6908	5599,7186,5879,5604,814,1147,5532,2355,3727,8878,8651,3551,5296,5601,4286,3726,2354,8503,9020,3459,4791,5970,5609,207,5468,208,5295,2274,3454,7297,6773,5595,9021,2885,2534,1535,23118,5608,5534,5533,10454,5594	MAPK8,TRAF2,RAC1,MAP2K1,CAMK4,CHUK,PPP3CB,FOSL2,JUND,SQSTM1,SOCS1,IKBKB,PIK3R2,MAPK9,MITF,JUNB,FOSB,PIK3R3,MAP3K14,IFNGR1,NFKB2,RELA,MAP2K7,AKT1,PPARG,AKT2,PIK3R1,FHL2,IFNAR1,TYK2,STAT2,MAPK3,SOCS3,GRB2,FYN,CYBA,TAB2,MAP2K6,PPP3R1,PPP3CC,TAB1,MAPK1
hsa04623	Cytosolic DNA-sensing pathway	0.892217348492035	-0.114045511854695	63	19	0.00747149036570979	2543	6908	29110,5441,5440,171568,84265,3606,1147,3661,51728,11128,3569,3551,5434,103,55703,9533,4793,5970,10621	TBK1,POLR2L,POLR2K,POLR3H,POLR3GL,IL18,CHUK,IRF3,POLR3K,POLR3A,IL6,IKBKB,POLR2E,ADAR,POLR3B,POLR1C,NFKBIB,RELA,POLR3F
ko04623	Cytosolic DNA-sensing pathway	0.892217348492035	-0.114045511854695	63	19	0.00747149036570979	2543	6908	29110,5441,5440,171568,84265,3606,1147,3661,51728,11128,3569,3551,5434,103,55703,9533,4793,5970,10621	TBK1,POLR2L,POLR2K,POLR3H,POLR3GL,IL18,CHUK,IRF3,POLR3K,POLR3A,IL6,IKBKB,POLR2E,ADAR,POLR3B,POLR1C,NFKBIB,RELA,POLR3F
ko04973	Carbohydrate digestion and absorption	0.898100839856879	-0.107472923157158	45	13	0.00511207235548565	2543	6908	476,207,208,5296,5295,83756,8503,482,80201,481,3098,92579,3101	ATP1A1,AKT1,AKT2,PIK3R2,PIK3R1,TAS1R3,PIK3R3,ATP1B2,HKDC1,ATP1B1,HK1,G6PC3,HK3
hsa04973	Carbohydrate digestion and absorption	0.898100839856879	-0.107472923157158	45	13	0.00511207235548565	2543	6908	476,207,208,5296,5295,83756,8503,482,80201,481,3098,92579,3101	ATP1A1,AKT1,AKT2,PIK3R2,PIK3R1,TAS1R3,PIK3R3,ATP1B2,HKDC1,ATP1B1,HK1,G6PC3,HK3
ko00232	Caffeine metabolism	0.89935478630794	-0.106077676858745	5	1	0.000393236335037357	2543	6908	9	NAT1
hsa00400	Phenylalanine, tyrosine and tryptophan biosynthesis	0.89935478630794	-0.106077676858745	5	1	0.000393236335037357	2543	6908	2806	GOT2
ko00400	Phenylalanine, tyrosine and tryptophan biosynthesis	0.89935478630794	-0.106077676858745	5	1	0.000393236335037357	2543	6908	2806	GOT2
hsa00232	Caffeine metabolism	0.89935478630794	-0.106077676858745	5	1	0.000393236335037357	2543	6908	9	NAT1
ko04728	Dopaminergic synapse	0.902117233361838	-0.103010796897273	129	41	0.0161226897365317	2543	6908	5599,1388,2785,5520,808,2782,5532,10488,3709,5566,2783,5501,5519,3799,10681,5601,5499,5521,2771,1386,5567,468,207,2931,208,3710,2773,2770,2778,817,5529,59345,406,3708,5500,5527,2932,5533,9575,409,5528	MAPK8,ATF6B,GNG3,PPP2R2A,CALM3,GNB1,PPP3CB,CREB3,ITPR2,PRKACA,GNB2,PPP1CC,PPP2R1B,KIF5B,GNB5,MAPK9,PPP1CA,PPP2R2B,GNAI2,ATF2,PRKACB,ATF4,AKT1,GSK3A,AKT2,ITPR3,GNAI3,GNAI1,GNAS,CAMK2D,PPP2R5E,GNB4,ARNTL,ITPR1,PPP1CB,PPP2R5C,GSK3B,PPP3CC,CLOCK,ARRB2,PPP2R5D
hsa04728	Dopaminergic synapse	0.902117233361838	-0.103010796897273	129	41	0.0161226897365317	2543	6908	5599,1388,2785,5520,808,2782,5532,10488,3709,5566,2783,5501,5519,3799,10681,5601,5499,5521,2771,1386,5567,468,207,2931,208,3710,2773,2770,2778,817,5529,59345,406,3708,5500,5527,2932,5533,9575,409,5528	MAPK8,ATF6B,GNG3,PPP2R2A,CALM3,GNB1,PPP3CB,CREB3,ITPR2,PRKACA,GNB2,PPP1CC,PPP2R1B,KIF5B,GNB5,MAPK9,PPP1CA,PPP2R2B,GNAI2,ATF2,PRKACB,ATF4,AKT1,GSK3A,AKT2,ITPR3,GNAI3,GNAI1,GNAS,CAMK2D,PPP2R5E,GNB4,ARNTL,ITPR1,PPP1CB,PPP2R5C,GSK3B,PPP3CC,CLOCK,ARRB2,PPP2R5D
hsa04924	Renin secretion	0.907864272419223	-0.0966603912685614	64	19	0.00747149036570979	2543	6908	3759,5734,4881,808,5532,3709,154,3710,2773,5566,5139,2770,2778,3708,5534,84876,5533,2771,5567	KCNJ2,PTGER4,NPR1,CALM3,PPP3CB,ITPR2,ADRB2,ITPR3,GNAI3,PRKACA,PDE3A,GNAI1,GNAS,ITPR1,PPP3R1,ORAI1,PPP3CC,GNAI2,PRKACB
ko04924	Renin secretion	0.907864272419223	-0.0966603912685614	64	19	0.00747149036570979	2543	6908	3759,5734,4881,808,5532,3709,154,3710,2773,5566,5139,2770,2778,3708,5534,84876,5533,2771,5567	KCNJ2,PTGER4,NPR1,CALM3,PPP3CB,ITPR2,ADRB2,ITPR3,GNAI3,PRKACA,PDE3A,GNAI1,GNAS,ITPR1,PPP3R1,ORAI1,PPP3CC,GNAI2,PRKACB
ko04620	Toll-like receptor signaling pathway	0.908426213358976	-0.096041612541169	106	33	0.0129767990562328	2543	6908	5599,5879,5604,1147,3661,5606,3592,3551,5296,5601,51135,8503,841,5970,29110,5609,207,208,5295,958,3454,10333,5605,3663,5595,23118,3569,5608,148022,10454,5594,6416,114609	MAPK8,RAC1,MAP2K1,CHUK,IRF3,MAP2K3,IL12A,IKBKB,PIK3R2,MAPK9,IRAK4,PIK3R3,CASP8,RELA,TBK1,MAP2K7,AKT1,AKT2,PIK3R1,CD40,IFNAR1,TLR6,MAP2K2,IRF5,MAPK3,TAB2,IL6,MAP2K6,TICAM1,TAB1,MAPK1,MAP2K4,TIRAP
hsa04620	Toll-like receptor signaling pathway	0.908426213358976	-0.096041612541169	106	33	0.0129767990562328	2543	6908	5599,5879,5604,1147,3661,5606,3592,3551,5296,5601,51135,8503,841,5970,29110,5609,207,208,5295,958,3454,10333,5605,3663,5595,23118,3569,5608,148022,10454,5594,6416,114609	MAPK8,RAC1,MAP2K1,CHUK,IRF3,MAP2K3,IL12A,IKBKB,PIK3R2,MAPK9,IRAK4,PIK3R3,CASP8,RELA,TBK1,MAP2K7,AKT1,AKT2,PIK3R1,CD40,IFNAR1,TLR6,MAP2K2,IRF5,MAPK3,TAB2,IL6,MAP2K6,TICAM1,TAB1,MAPK1,MAP2K4,TIRAP
ko05152	Tuberculosis	0.915193892568934	-0.0886193317082694	177	57	0.0224144710971294	2543	6908	5599,3916,2033,836,5894,537,8877,808,3606,5532,8411,1387,22925,3592,5601,51135,581,23545,3717,5993,11151,51606,3459,3329,841,5970,3588,9114,4801,1263,387,207,208,7879,842,10892,8625,535,5868,23365,5869,10333,3587,5595,817,10312,3569,4802,5534,1054,527,5533,317,56848,5594,5878,114609	MAPK8,LAMP1,EP300,CASP3,RAF1,ATP6AP1,SPHK1,CALM3,IL18,PPP3CB,EEA1,CREBBP,PLA2R1,IL12A,MAPK9,IRAK4,BAX,ATP6V0A2,JAK2,RFX5,CORO1A,ATP6V1H,IFNGR1,HSPD1,CASP8,RELA,IL10RB,ATP6V0D1,NFYB,PLK3,RHOA,AKT1,AKT2,RAB7A,CASP9,MALT1,RFXANK,ATP6V0A1,RAB5A,ARHGEF12,RAB5B,TLR6,IL10RA,MAPK3,CAMK2D,TCIRG1,IL6,NFYC,PPP3R1,CEBPG,ATP6V0C,PPP3CC,APAF1,SPHK2,MAPK1,RAB5C,TIRAP
hsa05152	Tuberculosis	0.915193892568934	-0.0886193317082694	177	57	0.0224144710971294	2543	6908	5599,3916,2033,836,5894,537,8877,808,3606,5532,8411,1387,22925,3592,5601,51135,581,23545,3717,5993,11151,51606,3459,3329,841,5970,3588,9114,4801,1263,387,207,208,7879,842,10892,8625,535,5868,23365,5869,10333,3587,5595,817,10312,3569,4802,5534,1054,527,5533,317,56848,5594,5878,114609	MAPK8,LAMP1,EP300,CASP3,RAF1,ATP6AP1,SPHK1,CALM3,IL18,PPP3CB,EEA1,CREBBP,PLA2R1,IL12A,MAPK9,IRAK4,BAX,ATP6V0A2,JAK2,RFX5,CORO1A,ATP6V1H,IFNGR1,HSPD1,CASP8,RELA,IL10RB,ATP6V0D1,NFYB,PLK3,RHOA,AKT1,AKT2,RAB7A,CASP9,MALT1,RFXANK,ATP6V0A1,RAB5A,ARHGEF12,RAB5B,TLR6,IL10RA,MAPK3,CAMK2D,TCIRG1,IL6,NFYC,PPP3R1,CEBPG,ATP6V0C,PPP3CC,APAF1,SPHK2,MAPK1,RAB5C,TIRAP
hsa00983	Drug metabolism - other enzymes	0.91535008836267	-0.0884486766508197	46	13	0.00511207235548565	2543	6908	3251,1890,3704,9,54963,7378,3614,8833,7372,1806,3615,7172,7084	HPRT1,TYMP,ITPA,NAT1,UCKL1,UPP1,IMPDH1,GMPS,UMPS,DPYD,IMPDH2,TPMT,TK2
ko00983	Drug metabolism - other enzymes	0.91535008836267	-0.0884486766508197	46	13	0.00511207235548565	2543	6908	3251,1890,3704,9,54963,7378,3614,8833,7372,1806,3615,7172,7084	HPRT1,TYMP,ITPA,NAT1,UCKL1,UPP1,IMPDH1,GMPS,UMPS,DPYD,IMPDH2,TPMT,TK2
hsa04070	Phosphatidylinositol signaling system	0.918815511204758	-0.0846699262844891	98	30	0.0117970900511207	2543	6908	3612,8760,3636,9807,90809,5295,79837,808,5297,8527,3709,10423,3710,8394,8898,55361,8396,5335,64768,5298,9110,4952,54928,5296,3708,253430,8503,200576,3706,3613	IMPA1,CDS2,INPPL1,IP6K1,TMEM55B,PIK3R1,PIP4K2C,CALM3,PI4KA,DGKD,ITPR2,CDIPT,ITPR3,PIP5K1A,MTMR2,PI4K2A,PIP4K2B,PLCG1,IPPK,PI4KB,MTMR4,OCRL,IMPAD1,PIK3R2,ITPR1,IPMK,PIK3R3,PIKFYVE,ITPKA,IMPA2
ko04070	Phosphatidylinositol signaling system	0.918815511204758	-0.0846699262844891	98	30	0.0117970900511207	2543	6908	3612,8760,3636,9807,90809,5295,79837,808,5297,8527,3709,10423,3710,8394,8898,55361,8396,5335,64768,5298,9110,4952,54928,5296,3708,253430,8503,200576,3706,3613	IMPA1,CDS2,INPPL1,IP6K1,TMEM55B,PIK3R1,PIP4K2C,CALM3,PI4KA,DGKD,ITPR2,CDIPT,ITPR3,PIP5K1A,MTMR2,PI4K2A,PIP4K2B,PLCG1,IPPK,PI4KB,MTMR4,OCRL,IMPAD1,PIK3R2,ITPR1,IPMK,PIK3R3,PIKFYVE,ITPKA,IMPA2
hsa05218	Melanoma	0.920223181770997	-0.0831390494774578	71	21	0.00825796303578451	2543	6908	673,207,5894,208,5295,2257,5604,1871,1026,5605,2260,5595,4193,5296,4286,8503,5594,1870,3265,1021,1029	BRAF,AKT1,RAF1,AKT2,PIK3R1,FGF12,MAP2K1,E2F3,CDKN1A,MAP2K2,FGFR1,MAPK3,MDM2,PIK3R2,MITF,PIK3R3,MAPK1,E2F2,HRAS,CDK6,CDKN2A
ko05218	Melanoma	0.920223181770997	-0.0831390494774578	71	21	0.00825796303578451	2543	6908	673,207,5894,208,5295,2257,5604,1871,1026,5605,2260,5595,4193,5296,4286,8503,5594,1870,3265,1021,1029	BRAF,AKT1,RAF1,AKT2,PIK3R1,FGF12,MAP2K1,E2F3,CDKN1A,MAP2K2,FGFR1,MAPK3,MDM2,PIK3R2,MITF,PIK3R3,MAPK1,E2F2,HRAS,CDK6,CDKN2A
ko04024	cAMP signaling pathway	0.928264988206365	-0.0744380393207344	199	64	0.0251671254423909	2543	6908	10398,5599,2033,5894,5879,5604,5566,5881,5139,1387,5906,488,5296,115,8503,5144,5499,5970,5567,207,208,5727,481,2773,2770,817,476,5500,482,6093,5594,673,64411,4659,7410,2550,6662,808,814,10488,5501,2737,5601,268,6548,84876,2771,22800,9475,387,6237,5141,5295,5908,5465,4881,154,5605,5595,2778,51,5337,8310,493	MYL9,MAPK8,EP300,RAF1,RAC1,MAP2K1,PRKACA,RAC3,PDE3A,CREBBP,RAP1A,ATP2A2,PIK3R2,ADCY9,PIK3R3,PDE4D,PPP1CA,RELA,PRKACB,AKT1,AKT2,PTCH1,ATP1B1,GNAI3,GNAI1,CAMK2D,ATP1A1,PPP1CB,ATP1B2,ROCK1,MAPK1,BRAF,ARAP3,PPP1R12A,VAV2,GABBR1,SOX9,CALM3,CAMK4,CREB3,PPP1CC,GLI3,MAPK9,AMH,SLC9A1,ORAI1,GNAI2,RRAS2,ROCK2,RHOA,RRAS,PDE4A,PIK3R1,RAP1B,PPARA,NPR1,ADRB2,MAP2K2,MAPK3,GNAS,ACOX1,PLD1,ACOX3,ATP2B4
hsa04024	cAMP signaling pathway	0.928264988206365	-0.0744380393207344	199	64	0.0251671254423909	2543	6908	10398,5599,2033,5894,5879,5604,5566,5881,5139,1387,5906,488,5296,115,8503,5144,5499,5970,5567,207,208,5727,481,2773,2770,817,476,5500,482,6093,5594,673,64411,4659,7410,2550,6662,808,814,10488,5501,2737,5601,268,6548,84876,2771,22800,9475,387,6237,5141,5295,5908,5465,4881,154,5605,5595,2778,51,5337,8310,493	MYL9,MAPK8,EP300,RAF1,RAC1,MAP2K1,PRKACA,RAC3,PDE3A,CREBBP,RAP1A,ATP2A2,PIK3R2,ADCY9,PIK3R3,PDE4D,PPP1CA,RELA,PRKACB,AKT1,AKT2,PTCH1,ATP1B1,GNAI3,GNAI1,CAMK2D,ATP1A1,PPP1CB,ATP1B2,ROCK1,MAPK1,BRAF,ARAP3,PPP1R12A,VAV2,GABBR1,SOX9,CALM3,CAMK4,CREB3,PPP1CC,GLI3,MAPK9,AMH,SLC9A1,ORAI1,GNAI2,RRAS2,ROCK2,RHOA,RRAS,PDE4A,PIK3R1,RAP1B,PPARA,NPR1,ADRB2,MAP2K2,MAPK3,GNAS,ACOX1,PLD1,ACOX3,ATP2B4
hsa04925	Aldosterone synthesis and secretion	0.930303323908149	-0.0722445912717856	81	24	0.00943767204089658	2543	6908	468,1388,8913,3164,8536,814,4881,808,3709,10488,3710,5566,2767,2778,5581,466,817,221955,115,3708,84876,25865,1386,5567	ATF4,ATF6B,CACNA1G,NR4A1,CAMK1,CAMK4,NPR1,CALM3,ITPR2,CREB3,ITPR3,PRKACA,GNA11,GNAS,PRKCE,ATF1,CAMK2D,DAGLB,ADCY9,ITPR1,ORAI1,PRKD2,ATF2,PRKACB
ko04925	Aldosterone synthesis and secretion	0.930303323908149	-0.0722445912717856	81	24	0.00943767204089658	2543	6908	468,1388,8913,3164,8536,814,4881,808,3709,10488,3710,5566,2767,2778,5581,466,817,221955,115,3708,84876,25865,1386,5567	ATF4,ATF6B,CACNA1G,NR4A1,CAMK1,CAMK4,NPR1,CALM3,ITPR2,CREB3,ITPR3,PRKACA,GNA11,GNAS,PRKCE,ATF1,CAMK2D,DAGLB,ADCY9,ITPR1,ORAI1,PRKD2,ATF2,PRKACB
ko00512	Mucin type O-Glycan biosynthesis	0.931276979855506	-0.0711985380511188	31	8	0.00314589068029886	2543	6908	29071,8693,56913,63917,55568,51809,6482,374378	C1GALT1C1,GALNT4,C1GALT1,GALNT11,GALNT10,GALNT7,ST3GAL1,GALNT18
hsa00512	Mucin type O-Glycan biosynthesis	0.931276979855506	-0.0711985380511188	31	8	0.00314589068029886	2543	6908	56913,29071,63917,8693,51809,55568,374378,6482	C1GALT1,C1GALT1C1,GALNT11,GALNT4,GALNT7,GALNT10,GALNT18,ST3GAL1
ko00592	alpha-Linolenic acid metabolism	0.942300258472791	-0.0594313094695695	25	6	0.00235941801022414	2543	6908	81579,11145,30,8310,51,8398	PLA2G12A,PLA2G16,ACAA1,ACOX3,ACOX1,PLA2G6
hsa00592	alpha-Linolenic acid metabolism	0.942300258472791	-0.0594313094695695	25	6	0.00235941801022414	2543	6908	81579,11145,30,8310,8398,51	PLA2G12A,PLA2G16,ACAA1,ACOX3,PLA2G6,ACOX1
hsa05031	Amphetamine addiction	0.944008124822391	-0.0576205060702947	67	19	0.00747149036570979	2543	6908	23411,468,1388,814,808,5532,10488,5566,5501,2778,817,2354,5534,3065,5500,5533,5499,1386,5567	SIRT1,ATF4,ATF6B,CAMK4,CALM3,PPP3CB,CREB3,PRKACA,PPP1CC,GNAS,CAMK2D,FOSB,PPP3R1,HDAC1,PPP1CB,PPP3CC,PPP1CA,ATF2,PRKACB
ko05031	Amphetamine addiction	0.944008124822391	-0.0576205060702947	67	19	0.00747149036570979	2543	6908	23411,468,1388,814,808,5532,10488,5566,5501,2778,817,2354,5534,3065,5500,5533,5499,1386,5567	SIRT1,ATF4,ATF6B,CAMK4,CALM3,PPP3CB,CREB3,PRKACA,PPP1CC,GNAS,CAMK2D,FOSB,PPP3R1,HDAC1,PPP1CB,PPP3CC,PPP1CA,ATF2,PRKACB
hsa05142	Chagas disease (American trypanosomiasis)	0.946423701789781	-0.0550649224749866	104	31	0.0121903263861581	2543	6908	5599,207,208,5295,5520,1147,2773,10333,2767,5519,5595,2770,2778,4088,811,3592,4087,3569,3551,5296,51135,5601,8503,148022,5521,3459,841,2771,5970,5594,6416	MAPK8,AKT1,AKT2,PIK3R1,PPP2R2A,CHUK,GNAI3,TLR6,GNA11,PPP2R1B,MAPK3,GNAI1,GNAS,SMAD3,CALR,IL12A,SMAD2,IL6,IKBKB,PIK3R2,IRAK4,MAPK9,PIK3R3,TICAM1,PPP2R2B,IFNGR1,CASP8,GNAI2,RELA,MAPK1,MAP2K4
ko05142	Chagas disease (American trypanosomiasis)	0.946423701789781	-0.0550649224749866	104	31	0.0121903263861581	2543	6908	5599,207,208,5295,5520,1147,2773,10333,2767,5519,5595,2770,2778,4088,811,3592,4087,3569,3551,5296,51135,5601,8503,148022,5521,3459,841,2771,5970,5594,6416	MAPK8,AKT1,AKT2,PIK3R1,PPP2R2A,CHUK,GNAI3,TLR6,GNA11,PPP2R1B,MAPK3,GNAI1,GNAS,SMAD3,CALR,IL12A,SMAD2,IL6,IKBKB,PIK3R2,IRAK4,MAPK9,PIK3R3,TICAM1,PPP2R2B,IFNGR1,CASP8,GNAI2,RELA,MAPK1,MAP2K4
hsa05416	Viral myocarditis	0.947757707531	-0.0536563921671649	58	16	0.00629178136059772	2543	6908	836,71,5879,842,8672,857,958,1982,1605,5881,3105,25,1981,2534,60,841	CASP3,ACTG1,RAC1,CASP9,EIF4G3,CAV1,CD40,EIF4G2,DAG1,RAC3,HLA-A,ABL1,EIF4G1,FYN,ACTB,CASP8
hsa04918	Thyroid hormone synthesis	0.951983501751426	-0.0492075744339793	71	20	0.00786472670074715	2543	6908	468,1388,3709,10488,481,821,3710,5566,7270,493869,9601,2778,476,115,3708,8458,482,1386,2876,5567	ATF4,ATF6B,ITPR2,CREB3,ATP1B1,CANX,ITPR3,PRKACA,TTF1,GPX8,PDIA4,GNAS,ATP1A1,ADCY9,ITPR1,TTF2,ATP1B2,ATF2,GPX1,PRKACB
ko04918	Thyroid hormone synthesis	0.951983501751426	-0.0492075744339793	71	20	0.00786472670074715	2543	6908	468,1388,3709,10488,481,821,3710,5566,7270,493869,9601,2778,476,115,3708,8458,482,1386,2876,5567	ATF4,ATF6B,ITPR2,CREB3,ATP1B1,CANX,ITPR3,PRKACA,TTF1,GPX8,PDIA4,GNAS,ATP1A1,ADCY9,ITPR1,TTF2,ATP1B2,ATF2,GPX1,PRKACB
hsa04270	Vascular smooth muscle contraction	0.952869454418171	-0.0482773685325116	120	36	0.0141565080613449	2543	6908	10398,673,4659,5894,5604,808,81579,3709,5566,5501,140465,5581,9138,115,54776,59,4637,5499,8398,9475,5567,387,4881,23365,3710,2767,5605,5595,2778,2768,3708,5500,4660,6093,10672,5594	MYL9,BRAF,PPP1R12A,RAF1,MAP2K1,CALM3,PLA2G12A,ITPR2,PRKACA,PPP1CC,MYL6B,PRKCE,ARHGEF1,ADCY9,PPP1R12C,ACTA2,MYL6,PPP1CA,PLA2G6,ROCK2,PRKACB,RHOA,NPR1,ARHGEF12,ITPR3,GNA11,MAP2K2,MAPK3,GNAS,GNA12,ITPR1,PPP1CB,PPP1R12B,ROCK1,GNA13,MAPK1
ko04270	Vascular smooth muscle contraction	0.952869454418171	-0.0482773685325116	120	36	0.0141565080613449	2543	6908	10398,673,4659,5894,5604,808,81579,3709,5566,5501,140465,5581,9138,115,54776,59,4637,5499,8398,9475,5567,387,4881,23365,3710,2767,5605,5595,2778,2768,3708,5500,4660,6093,10672,5594	MYL9,BRAF,PPP1R12A,RAF1,MAP2K1,CALM3,PLA2G12A,ITPR2,PRKACA,PPP1CC,MYL6B,PRKCE,ARHGEF1,ADCY9,PPP1R12C,ACTA2,MYL6,PPP1CA,PLA2G6,ROCK2,PRKACB,RHOA,NPR1,ARHGEF12,ITPR3,GNA11,MAP2K2,MAPK3,GNAS,GNA12,ITPR1,PPP1CB,PPP1R12B,ROCK1,GNA13,MAPK1
hsa05030	Cocaine addiction	0.953082061794488	-0.0480542701216759	49	13	0.00511207235548565	2543	6908	2778,468,1388,2354,1742,10488,2771,5970,5566,1386,2773,5567,2770	GNAS,ATF4,ATF6B,FOSB,DLG4,CREB3,GNAI2,RELA,PRKACA,ATF2,GNAI3,PRKACB,GNAI1
ko05030	Cocaine addiction	0.953082061794488	-0.0480542701216759	49	13	0.00511207235548565	2543	6908	2778,468,1388,2354,1742,10488,2771,5970,5566,1386,2773,5567,2770	GNAS,ATF4,ATF6B,FOSB,DLG4,CREB3,GNAI2,RELA,PRKACA,ATF2,GNAI3,PRKACB,GNAI1
ko00040	Pentose and glucuronate interconversions	0.953768150358874	-0.0473346660441037	36	9	0.00353912701533622	2543	6908	27294,9942,7360,51181,7358,231,6120,224,10327	DHDH,XYLB,UGP2,DCXR,UGDH,AKR1B1,RPE,ALDH3A2,AKR1A1
hsa00040	Pentose and glucuronate interconversions	0.953768150358874	-0.0473346660441037	36	9	0.00353912701533622	2543	6908	27294,9942,7360,51181,7358,231,6120,224,10327	DHDH,XYLB,UGP2,DCXR,UGDH,AKR1B1,RPE,ALDH3A2,AKR1A1
hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	0.955880391330122	-0.0451224874295242	26	6	0.00235941801022414	2543	6908	6484,10678,11041,8702,6487,8704	ST3GAL4,B3GNT2,B4GAT1,B4GALT4,ST3GAL3,B4GALT2
ko00601	Glycosphingolipid biosynthesis - lacto and neolacto series	0.955880391330122	-0.0451224874295242	26	6	0.00235941801022414	2543	6908	6484,10678,11041,8702,6487,8704	ST3GAL4,B3GNT2,B4GAT1,B4GALT4,ST3GAL3,B4GALT2
hsa00460	Cyanoamino acid metabolism	0.959852948403356	-0.0409751849998214	7	1	0.000393236335037357	2543	6908	6472	SHMT2
ko00460	Cyanoamino acid metabolism	0.959852948403356	-0.0409751849998214	7	1	0.000393236335037357	2543	6908	6472	SHMT2
ko04062	Chemokine signaling pathway	0.960642595522047	-0.0401528481131906	187	58	0.0228077074321667	2543	6908	673,2785,2921,5894,5879,7410,5604,2782,1147,6777,2920,2870,4067,5566,2309,2783,1399,58191,5906,10681,6464,3551,5296,115,8503,3717,6774,5970,2771,9475,5567,6655,387,207,2931,6654,208,5295,5908,5747,9564,2773,6773,5595,2770,2885,7852,1398,8976,59345,5590,2185,2932,6093,4793,5594,409,3265	BRAF,GNG3,CXCL3,RAF1,RAC1,VAV2,MAP2K1,GNB1,CHUK,STAT5B,CXCL2,GRK6,LYN,PRKACA,FOXO3,GNB2,CRKL,CXCL16,RAP1A,GNB5,SHC1,IKBKB,PIK3R2,ADCY9,PIK3R3,JAK2,STAT3,RELA,GNAI2,ROCK2,PRKACB,SOS2,RHOA,AKT1,GSK3A,SOS1,AKT2,PIK3R1,RAP1B,PTK2,BCAR1,GNAI3,STAT2,MAPK3,GNAI1,GRB2,CXCR4,CRK,WASL,GNB4,PRKCZ,PTK2B,GSK3B,ROCK1,NFKBIB,MAPK1,ARRB2,HRAS
hsa04062	Chemokine signaling pathway	0.960642595522047	-0.0401528481131906	187	58	0.0228077074321667	2543	6908	673,2785,2921,5894,5879,7410,5604,2782,1147,6777,2920,2870,4067,5566,2309,2783,1399,58191,5906,10681,6464,3551,5296,115,8503,3717,6774,5970,2771,9475,5567,6655,387,207,2931,6654,208,5295,5908,5747,9564,2773,6773,5595,2770,2885,7852,1398,8976,59345,5590,2185,2932,6093,4793,5594,409,3265	BRAF,GNG3,CXCL3,RAF1,RAC1,VAV2,MAP2K1,GNB1,CHUK,STAT5B,CXCL2,GRK6,LYN,PRKACA,FOXO3,GNB2,CRKL,CXCL16,RAP1A,GNB5,SHC1,IKBKB,PIK3R2,ADCY9,PIK3R3,JAK2,STAT3,RELA,GNAI2,ROCK2,PRKACB,SOS2,RHOA,AKT1,GSK3A,SOS1,AKT2,PIK3R1,RAP1B,PTK2,BCAR1,GNAI3,STAT2,MAPK3,GNAI1,GRB2,CXCR4,CRK,WASL,GNB4,PRKCZ,PTK2B,GSK3B,ROCK1,NFKBIB,MAPK1,ARRB2,HRAS
hsa04015	Rap1 signaling pathway	0.962422020647593	-0.0383022336112872	211	66	0.0259535981124656	2543	6908	3397,71,5894,5879,5604,22808,5881,23566,84612,5606,1399,5906,1499,5899,5296,115,8503,9732,207,208,2257,83593,7422,2773,2260,260425,889,2770,5898,5335,1969,1398,1945,3688,5590,4254,60,1500,9223,5594,673,64411,9170,7410,808,5900,5217,51735,7057,7408,23094,5584,2771,7423,387,6237,5295,5908,9564,5605,5595,2778,3643,5608,25865,3265	ID1,ACTG1,RAF1,RAC1,MAP2K1,MRAS,RAC3,LPAR3,PARD6B,MAP2K3,CRKL,RAP1A,CTNNB1,RALB,PIK3R2,ADCY9,PIK3R3,DOCK4,AKT1,AKT2,FGF12,RASSF5,VEGFA,GNAI3,FGFR1,MAGI3,KRIT1,GNAI1,RALA,PLCG1,EPHA2,CRK,EFNA4,ITGB1,PRKCZ,KITLG,ACTB,CTNND1,MAGI1,MAPK1,BRAF,ARAP3,LPAR2,VAV2,CALM3,RALGDS,PFN2,RAPGEF6,THBS1,VASP,SIPA1L3,PRKCI,GNAI2,VEGFB,RHOA,RRAS,PIK3R1,RAP1B,BCAR1,MAP2K2,MAPK3,GNAS,INSR,MAP2K6,PRKD2,HRAS
ko04015	Rap1 signaling pathway	0.962422020647593	-0.0383022336112872	211	66	0.0259535981124656	2543	6908	3397,71,5894,5879,5604,22808,5881,23566,84612,5606,1399,5906,1499,5899,5296,115,8503,9732,207,208,2257,83593,7422,2773,2260,260425,889,2770,5898,5335,1969,1398,1945,3688,5590,4254,60,1500,9223,5594,673,64411,9170,7410,808,5900,5217,51735,7057,7408,23094,5584,2771,7423,387,6237,5295,5908,9564,5605,5595,2778,3643,5608,25865,3265	ID1,ACTG1,RAF1,RAC1,MAP2K1,MRAS,RAC3,LPAR3,PARD6B,MAP2K3,CRKL,RAP1A,CTNNB1,RALB,PIK3R2,ADCY9,PIK3R3,DOCK4,AKT1,AKT2,FGF12,RASSF5,VEGFA,GNAI3,FGFR1,MAGI3,KRIT1,GNAI1,RALA,PLCG1,EPHA2,CRK,EFNA4,ITGB1,PRKCZ,KITLG,ACTB,CTNND1,MAGI1,MAPK1,BRAF,ARAP3,LPAR2,VAV2,CALM3,RALGDS,PFN2,RAPGEF6,THBS1,VASP,SIPA1L3,PRKCI,GNAI2,VEGFB,RHOA,RRAS,PIK3R1,RAP1B,BCAR1,MAP2K2,MAPK3,GNAS,INSR,MAP2K6,PRKD2,HRAS
hsa05322	Systemic lupus erythematosus	0.963880389982327	-0.036788068851571	134	40	0.0157294534014943	2543	6908	3015,8367,8358,8350,85235,8969,8360,440689,121504,8365,8366,8364,6737,9555,653604,8345,717,92815,8331,8352,8968,8336,715,87,8368,958,8357,94239,8330,8294,3012,8334,8351,3014,81,6741,8338,3020,6738,8354	H2AFZ,HIST1H4E,HIST1H3B,HIST1H3A,HIST1H2AH,HIST1H2AG,HIST1H4D,HIST2H2BF,HIST4H4,HIST1H4H,HIST1H4B,HIST1H4C,TRIM21,H2AFY,HIST2H3D,HIST1H2BH,C2,HIST3H2A,HIST1H2AJ,HIST1H3C,HIST1H3F,HIST1H2AM,C1R,ACTN1,HIST1H4L,CD40,HIST1H3H,H2AFV,HIST1H2AK,HIST1H4I,HIST1H2AE,HIST1H2AC,HIST1H3D,H2AFX,ACTN4,SSB,HIST2H2AC,H3F3A,TROVE2,HIST1H3I
ko05322	Systemic lupus erythematosus	0.963880389982327	-0.036788068851571	134	40	0.0157294534014943	2543	6908	3015,8367,8358,8350,85235,8969,8360,440689,121504,8365,8366,8364,6737,9555,653604,8345,717,92815,8331,8352,8968,8336,715,87,8368,958,8357,94239,8330,8294,3012,8334,8351,3014,81,6741,8338,3020,6738,8354	H2AFZ,HIST1H4E,HIST1H3B,HIST1H3A,HIST1H2AH,HIST1H2AG,HIST1H4D,HIST2H2BF,HIST4H4,HIST1H4H,HIST1H4B,HIST1H4C,TRIM21,H2AFY,HIST2H3D,HIST1H2BH,C2,HIST3H2A,HIST1H2AJ,HIST1H3C,HIST1H3F,HIST1H2AM,C1R,ACTN1,HIST1H4L,CD40,HIST1H3H,H2AFV,HIST1H2AK,HIST1H4I,HIST1H2AE,HIST1H2AC,HIST1H3D,H2AFX,ACTN4,SSB,HIST2H2AC,H3F3A,TROVE2,HIST1H3I
ko05414	Dilated cardiomyopathy	0.968259663579903	-0.0322549801775885	89	25	0.00983090837593394	2543	6908	7169,7170,71,7171,59285,3678,785,5566,3693,1605,4000,59283,2778,2010,488,783,3673,115,3688,60,784,3685,7168,781,5567	TPM2,TPM3,ACTG1,TPM4,CACNG6,ITGA5,CACNB4,PRKACA,ITGB5,DAG1,LMNA,CACNG8,GNAS,EMD,ATP2A2,CACNB2,ITGA2,ADCY9,ITGB1,ACTB,CACNB3,ITGAV,TPM1,CACNA2D1,PRKACB
hsa05414	Dilated cardiomyopathy	0.968259663579903	-0.0322549801775885	89	25	0.00983090837593394	2543	6908	7169,7170,71,7171,59285,3678,785,5566,3693,1605,4000,59283,2778,2010,488,783,3673,115,3688,60,784,3685,7168,781,5567	TPM2,TPM3,ACTG1,TPM4,CACNG6,ITGA5,CACNB4,PRKACA,ITGB5,DAG1,LMNA,CACNG8,GNAS,EMD,ATP2A2,CACNB2,ITGA2,ADCY9,ITGB1,ACTB,CACNB3,ITGAV,TPM1,CACNA2D1,PRKACB
hsa04971	Gastric acid secretion	0.971931715668142	-0.0284697283596658	74	20	0.00786472670074715	2543	6908	3759,7430,808,6522,3709,481,3710,2773,5566,2770,2778,817,476,115,3708,6548,482,60,2771,5567	KCNJ2,EZR,CALM3,SLC4A2,ITPR2,ATP1B1,ITPR3,GNAI3,PRKACA,GNAI1,GNAS,CAMK2D,ATP1A1,ADCY9,ITPR1,SLC9A1,ATP1B2,ACTB,GNAI2,PRKACB
ko04971	Gastric acid secretion	0.971931715668142	-0.0284697283596658	74	20	0.00786472670074715	2543	6908	3759,7430,808,6522,3709,481,3710,2773,5566,2770,2778,817,476,115,3708,6548,482,60,2771,5567	KCNJ2,EZR,CALM3,SLC4A2,ITPR2,ATP1B1,ITPR3,GNAI3,PRKACA,GNAI1,GNAS,CAMK2D,ATP1A1,ADCY9,ITPR1,SLC9A1,ATP1B2,ACTB,GNAI2,PRKACB
ko00565	Ether lipid metabolism	0.973117034527769	-0.0272509218837467	45	11	0.00432559968541093	2543	6908	8611,85465,5048,254531,8612,5049,81579,5337,11145,79888,8398	PLPP1,EPT1,PAFAH1B1,LPCAT4,PLPP2,PAFAH1B2,PLA2G12A,PLD1,PLA2G16,LPCAT1,PLA2G6
hsa00565	Ether lipid metabolism	0.973117034527769	-0.0272509218837467	45	11	0.00432559968541093	2543	6908	85465,8611,5048,8612,254531,81579,5049,5337,11145,79888,8398	EPT1,PLPP1,PAFAH1B1,PLPP2,LPCAT4,PLA2G12A,PAFAH1B2,PLD1,PLA2G16,LPCAT1,PLA2G6
ko00860	Porphyrin and chlorophyll metabolism	0.975341865524252	-0.0249672381341561	42	10	0.00393236335037357	2543	6908	124454,210,7390,1371,7389,211,644,3052,5498,326625	EARS2,ALAD,UROS,CPOX,UROD,ALAS1,BLVRA,HCCS,PPOX,MMAB
hsa00860	Porphyrin and chlorophyll metabolism	0.975341865524252	-0.0249672381341561	42	10	0.00393236335037357	2543	6908	124454,210,7390,1371,7389,211,644,3052,5498,326625	EARS2,ALAD,UROS,CPOX,UROD,ALAS1,BLVRA,HCCS,PPOX,MMAB
hsa00910	Nitrogen metabolism	0.976839402315805	-0.0234330188380603	17	3	0.00117970900511207	2543	6908	1373,2752,377677	CPS1,GLUL,CA13
hsa00360	Phenylalanine metabolism	0.976839402315805	-0.0234330188380603	17	3	0.00117970900511207	2543	6908	4282,221,2806	MIF,ALDH3B1,GOT2
ko00360	Phenylalanine metabolism	0.976839402315805	-0.0234330188380603	17	3	0.00117970900511207	2543	6908	4282,221,2806	MIF,ALDH3B1,GOT2
ko00910	Nitrogen metabolism	0.976839402315805	-0.0234330188380603	17	3	0.00117970900511207	2543	6908	1373,2752,377677	CPS1,GLUL,CA13
ko00500	Starch and sucrose metabolism	0.978695253227314	-0.0215349686415016	56	14	0.005505308690523	2543	6908	80146,2632,5236,55276,7360,5837,7358,283209,80201,3098,2595,92579,3101,178	UXS1,GBE1,PGM1,PGM2,UGP2,PYGM,UGDH,PGM2L1,HKDC1,HK1,GANC,G6PC3,HK3,AGL
hsa00500	Starch and sucrose metabolism	0.978695253227314	-0.0215349686415016	56	14	0.005505308690523	2543	6908	80146,2632,5236,55276,7360,5837,7358,283209,80201,3098,2595,92579,3101,178	UXS1,GBE1,PGM1,PGM2,UGP2,PYGM,UGDH,PGM2L1,HKDC1,HK1,GANC,G6PC3,HK3,AGL
hsa04750	Inflammatory mediator regulation of TRP channels	0.980079454710657	-0.0201216343686558	98	27	0.0106173810460087	2543	6908	5599,5295,5734,808,3709,3710,5566,5501,5606,2778,5581,5335,817,9311,5608,115,5601,3708,5296,5500,8503,5499,8398,3556,5567,3269,5029	MAPK8,PIK3R1,PTGER4,CALM3,ITPR2,ITPR3,PRKACA,PPP1CC,MAP2K3,GNAS,PRKCE,PLCG1,CAMK2D,ASIC3,MAP2K6,ADCY9,MAPK9,ITPR1,PIK3R2,PPP1CB,PIK3R3,PPP1CA,PLA2G6,IL1RAP,PRKACB,HRH1,P2RY2
ko04750	Inflammatory mediator regulation of TRP channels	0.980079454710657	-0.0201216343686558	98	27	0.0106173810460087	2543	6908	5599,5295,5734,808,3709,3710,5566,5501,5606,2778,5581,5335,817,9311,5608,115,5601,3708,5296,5500,8503,5499,8398,3556,5567,3269,5029	MAPK8,PIK3R1,PTGER4,CALM3,ITPR2,ITPR3,PRKACA,PPP1CC,MAP2K3,GNAS,PRKCE,PLCG1,CAMK2D,ASIC3,MAP2K6,ADCY9,MAPK9,ITPR1,PIK3R2,PPP1CB,PIK3R3,PPP1CA,PLA2G6,IL1RAP,PRKACB,HRH1,P2RY2
hsa05340	Primary immunodeficiency	0.98029710085241	-0.0198995891273682	36	8	0.00314589068029886	2543	6908	84876,6891,5993,958,115650,7374,8625,6890	ORAI1,TAP2,RFX5,CD40,TNFRSF13C,UNG,RFXANK,TAP1
ko05340	Primary immunodeficiency	0.98029710085241	-0.0198995891273682	36	8	0.00314589068029886	2543	6908	84876,6891,5993,958,115650,7374,8625,6890	ORAI1,TAP2,RFX5,CD40,TNFRSF13C,UNG,RFXANK,TAP1
hsa04725	Cholinergic synapse	0.981693137782019	-0.0184765064455898	111	31	0.0121903263861581	2543	6908	468,207,3759,2785,208,5295,5604,814,2782,3709,10488,3710,2773,5566,2783,2767,5595,2770,817,2534,10681,59345,5296,3708,115,8503,3717,2771,5594,3265,5567	ATF4,AKT1,KCNJ2,GNG3,AKT2,PIK3R1,MAP2K1,CAMK4,GNB1,ITPR2,CREB3,ITPR3,GNAI3,PRKACA,GNB2,GNA11,MAPK3,GNAI1,CAMK2D,FYN,GNB5,GNB4,PIK3R2,ITPR1,ADCY9,PIK3R3,JAK2,GNAI2,MAPK1,HRAS,PRKACB
ko04630	Jak-STAT signaling pathway	0.983932273590344	-0.0161982119507042	158	46	0.0180888714117184	2543	6908	51588,2033,3601,2475,5894,8835,3597,6777,1026,598,1387,1154,3592,8651,3572,5296,896,5781,8503,3717,1489,5292,3459,6774,3588,9655,6655,3590,207,6654,5777,208,5295,3454,7297,3587,6773,9021,30837,2885,10401,6778,3569,9063,6776,3265	PIAS4,EP300,IL15RA,MTOR,RAF1,SOCS2,IL13RA1,STAT5B,CDKN1A,BCL2L1,CREBBP,CISH,IL12A,SOCS1,IL6ST,PIK3R2,CCND3,PTPN11,PIK3R3,JAK2,CTF1,PIM1,IFNGR1,STAT3,IL10RB,SOCS5,SOS2,IL11RA,AKT1,SOS1,PTPN6,AKT2,PIK3R1,IFNAR1,TYK2,IL10RA,STAT2,SOCS3,SOCS7,GRB2,PIAS3,STAT6,IL6,PIAS2,STAT5A,HRAS
hsa04630	Jak-STAT signaling pathway	0.983932273590344	-0.0161982119507042	158	46	0.0180888714117184	2543	6908	51588,2033,3601,2475,5894,8835,3597,6777,1026,598,1387,1154,3592,8651,3572,5296,896,5781,8503,3717,1489,5292,3459,6774,3588,9655,6655,3590,207,6654,5777,208,5295,3454,7297,3587,6773,9021,30837,2885,10401,6778,3569,9063,6776,3265	PIAS4,EP300,IL15RA,MTOR,RAF1,SOCS2,IL13RA1,STAT5B,CDKN1A,BCL2L1,CREBBP,CISH,IL12A,SOCS1,IL6ST,PIK3R2,CCND3,PTPN11,PIK3R3,JAK2,CTF1,PIM1,IFNGR1,STAT3,IL10RB,SOCS5,SOS2,IL11RA,AKT1,SOS1,PTPN6,AKT2,PIK3R1,IFNAR1,TYK2,IL10RA,STAT2,SOCS3,SOCS7,GRB2,PIAS3,STAT6,IL6,PIAS2,STAT5A,HRAS
hsa04978	Mineral absorption	0.985470545274789	-0.0146360409387209	51	12	0.00471883602044829	2543	6908	538,2512,1317,476,482,4891,2495,4501,481,7779,79901,4494	ATP7A,FTL,SLC31A1,ATP1A1,ATP1B2,SLC11A2,FTH1,MT1X,ATP1B1,SLC30A1,CYBRD1,MT1F
ko04978	Mineral absorption	0.985470545274789	-0.0146360409387209	51	12	0.00471883602044829	2543	6908	538,2512,1317,476,482,4891,2495,4501,481,7779,79901,4494	ATP7A,FTL,SLC31A1,ATP1A1,ATP1B2,SLC11A2,FTH1,MT1X,ATP1B1,SLC30A1,CYBRD1,MT1F
hsa04975	Fat digestion and absorption	0.986684477653966	-0.0134049688187529	41	9	0.00353912701533622	2543	6908	8611,39,2806,8612,10554,84649,10999,81579,8694	PLPP1,ACAT2,GOT2,PLPP2,AGPAT1,DGAT2,SLC27A4,PLA2G12A,DGAT1
ko04975	Fat digestion and absorption	0.986684477653966	-0.0134049688187529	41	9	0.00353912701533622	2543	6908	8611,39,2806,8612,10554,84649,10999,81579,8694	PLPP1,ACAT2,GOT2,PLPP2,AGPAT1,DGAT2,SLC27A4,PLA2G12A,DGAT1
hsa00340	Histidine metabolism	0.988405918069915	-0.0116618173604003	23	4	0.00157294534014943	2543	6908	221,55748,224,223	ALDH3B1,CNDP2,ALDH3A2,ALDH9A1
ko00340	Histidine metabolism	0.988405918069915	-0.0116618173604003	23	4	0.00157294534014943	2543	6908	221,55748,224,223	ALDH3B1,CNDP2,ALDH3A2,ALDH9A1
hsa04977	Vitamin digestion and absorption	0.991734406689986	-0.00829994273627589	24	4	0.00157294534014943	2543	6908	55788,25974,10560,686	LMBRD1,MMACHC,SLC19A2,BTD
ko04977	Vitamin digestion and absorption	0.991734406689986	-0.00829994273627589	24	4	0.00157294534014943	2543	6908	55788,25974,10560,686	LMBRD1,MMACHC,SLC19A2,BTD
ko04724	Glutamatergic synapse	0.993702019151692	-0.00631789679388777	114	30	0.0117970900511207	2543	6908	81539,2785,1742,2782,5532,3709,85358,3710,2773,5566,2783,6505,2752,2918,5595,2770,2778,2744,9456,10681,59345,115,3708,5534,7220,5533,5337,2771,5594,5567	SLC38A1,GNG3,DLG4,GNB1,PPP3CB,ITPR2,SHANK3,ITPR3,GNAI3,PRKACA,GNB2,SLC1A1,GLUL,GRM8,MAPK3,GNAI1,GNAS,GLS,HOMER1,GNB5,GNB4,ADCY9,ITPR1,PPP3R1,TRPC1,PPP3CC,PLD1,GNAI2,MAPK1,PRKACB
hsa04724	Glutamatergic synapse	0.993702019151692	-0.00631789679388777	114	30	0.0117970900511207	2543	6908	81539,2785,1742,2782,5532,3709,85358,3710,2773,5566,2783,6505,2752,2918,5595,2770,2778,2744,9456,10681,59345,115,3708,5534,7220,5533,5337,2771,5594,5567	SLC38A1,GNG3,DLG4,GNB1,PPP3CB,ITPR2,SHANK3,ITPR3,GNAI3,PRKACA,GNB2,SLC1A1,GLUL,GRM8,MAPK3,GNAI1,GNAS,GLS,HOMER1,GNB5,GNB4,ADCY9,ITPR1,PPP3R1,TRPC1,PPP3CC,PLD1,GNAI2,MAPK1,PRKACB
ko04972	Pancreatic secretion	0.994121538188223	-0.00589580798101476	95	24	0.00943767204089658	2543	6908	387,5879,9545,5908,6522,81579,481,3709,3710,8766,2778,4218,5906,476,488,8671,115,3708,6548,7220,482,5874,6558,493	RHOA,RAC1,RAB3D,RAP1B,SLC4A2,PLA2G12A,ATP1B1,ITPR2,ITPR3,RAB11A,GNAS,RAB8A,RAP1A,ATP1A1,ATP2A2,SLC4A4,ADCY9,ITPR1,SLC9A1,TRPC1,ATP1B2,RAB27B,SLC12A2,ATP2B4
hsa04972	Pancreatic secretion	0.994121538188223	-0.00589580798101476	95	24	0.00943767204089658	2543	6908	387,5879,9545,5908,6522,81579,481,3709,3710,8766,2778,4218,5906,476,488,8671,115,3708,6548,7220,482,5874,6558,493	RHOA,RAC1,RAB3D,RAP1B,SLC4A2,PLA2G12A,ATP1B1,ITPR2,ITPR3,RAB11A,GNAS,RAB8A,RAP1A,ATP1A1,ATP2A2,SLC4A4,ADCY9,ITPR1,SLC9A1,TRPC1,ATP1B2,RAB27B,SLC12A2,ATP2B4
hsa04612	Antigen processing and presentation	0.996076337523523	-0.00393138023462544	77	18	0.00707825403067243	2543	6908	3326,8625,6890,2923,567,5720,821,3303,3105,3304,811,3305,3308,4802,6891,5993,3320,4801	HSP90AB1,RFXANK,TAP1,PDIA3,B2M,PSME1,CANX,HSPA1A,HLA-A,HSPA1B,CALR,HSPA1L,HSPA4,NFYC,TAP2,RFX5,HSP90AA1,NFYB
ko04612	Antigen processing and presentation	0.996076337523523	-0.00393138023462544	77	18	0.00707825403067243	2543	6908	3326,8625,6890,2923,567,5720,821,3303,3105,3304,811,3305,3308,4802,6891,5993,3320,4801	HSP90AB1,RFXANK,TAP1,PDIA3,B2M,PSME1,CANX,HSPA1A,HLA-A,HSPA1B,CALR,HSPA1L,HSPA4,NFYC,TAP2,RFX5,HSP90AA1,NFYB
hsa05032	Morphine addiction	0.99655063203776	-0.00345533074775235	91	22	0.00865119937082186	2543	6908	2564,5141,2785,2550,2782,2870,27115,2773,5566,2783,5139,2770,50940,2778,10681,59345,115,5150,5144,2771,409,5567	GABRE,PDE4A,GNG3,GABBR1,GNB1,GRK6,PDE7B,GNAI3,PRKACA,GNB2,PDE3A,GNAI1,PDE11A,GNAS,GNB5,GNB4,ADCY9,PDE7A,PDE4D,GNAI2,ARRB2,PRKACB
ko05032	Morphine addiction	0.99655063203776	-0.00345533074775235	91	22	0.00865119937082186	2543	6908	2564,5141,2785,2550,2782,2870,27115,2773,5566,2783,5139,2770,50940,2778,10681,59345,115,5150,5144,2771,409,5567	GABRE,PDE4A,GNG3,GABBR1,GNB1,GRK6,PDE7B,GNAI3,PRKACA,GNB2,PDE3A,GNAI1,PDE11A,GNAS,GNB5,GNB4,ADCY9,PDE7A,PDE4D,GNAI2,ARRB2,PRKACB
hsa04650	Natural killer cell mediated cytotoxicity	0.996966826356234	-0.00303778303803119	134	35	0.0137632717263075	2543	6908	6655,836,79465,673,6654,5777,5894,4277,5295,5879,7410,5604,8743,5532,3454,5881,5605,3105,5595,2885,5335,2534,6464,100507436,5296,5534,5781,8503,2185,5533,3459,8793,5594,3265,80329	SOS2,CASP3,ULBP3,BRAF,SOS1,PTPN6,RAF1,MICB,PIK3R1,RAC1,VAV2,MAP2K1,TNFSF10,PPP3CB,IFNAR1,RAC3,MAP2K2,HLA-A,MAPK3,GRB2,PLCG1,FYN,SHC1,MICA,PIK3R2,PPP3R1,PTPN11,PIK3R3,PTK2B,PPP3CC,IFNGR1,TNFRSF10D,MAPK1,HRAS,ULBP1
ko04650	Natural killer cell mediated cytotoxicity	0.996966826356234	-0.00303778303803119	134	35	0.0137632717263075	2543	6908	6655,836,79465,673,6654,5777,5894,4277,5295,5879,7410,5604,8743,5532,3454,5881,5605,3105,5595,2885,5335,2534,6464,100507436,5296,5534,5781,8503,2185,5533,3459,8793,5594,3265,80329	SOS2,CASP3,ULBP3,BRAF,SOS1,PTPN6,RAF1,MICB,PIK3R1,RAC1,VAV2,MAP2K1,TNFSF10,PPP3CB,IFNAR1,RAC3,MAP2K2,HLA-A,MAPK3,GRB2,PLCG1,FYN,SHC1,MICA,PIK3R2,PPP3R1,PTPN11,PIK3R3,PTK2B,PPP3CC,IFNGR1,TNFRSF10D,MAPK1,HRAS,ULBP1
ko00350	Tyrosine metabolism	0.996971981757033	-0.00303261196580164	35	6	0.00235941801022414	2543	6908	128,4282,221,2954,81889,2806	ADH5,MIF,ALDH3B1,GSTZ1,FAHD1,GOT2
hsa00350	Tyrosine metabolism	0.996971981757033	-0.00303261196580164	35	6	0.00235941801022414	2543	6908	128,4282,221,2954,81889,2806	ADH5,MIF,ALDH3B1,GSTZ1,FAHD1,GOT2
hsa04614	Renin-angiotensin system	0.997428218908821	-0.00257509380109782	23	3	0.00117970900511207	2543	6908	57486,7064,10159	NLN,THOP1,ATP6AP2
ko04614	Renin-angiotensin system	0.997428218908821	-0.00257509380109782	23	3	0.00117970900511207	2543	6908	57486,7064,10159	NLN,THOP1,ATP6AP2
hsa02010	ABC transporters	0.997958895924403	-0.00204318996735198	44	8	0.00314589068029886	2543	6908	23461,89845,9429,6890,6891,23456,215,10347	ABCA5,ABCC10,ABCG2,TAP1,TAP2,ABCB10,ABCD1,ABCA7
ko02010	ABC transporters	0.997958895924403	-0.00204318996735198	44	8	0.00314589068029886	2543	6908	23461,89845,9429,6890,23456,6891,215,10347	ABCA5,ABCC10,ABCG2,TAP1,ABCB10,TAP2,ABCD1,ABCA7
hsa04727	GABAergic synapse	0.998497415192775	-0.0015037148198782	88	20	0.00786472670074715	2543	6908	2564,81539,2785,2550,2782,9001,2773,5566,2783,2752,2770,2744,10681,11337,59345,115,2571,2771,5567,66008	GABRE,SLC38A1,GNG3,GABBR1,GNB1,HAP1,GNAI3,PRKACA,GNB2,GLUL,GNAI1,GLS,GNB5,GABARAP,GNB4,ADCY9,GAD1,GNAI2,PRKACB,TRAK2
ko04727	GABAergic synapse	0.998497415192775	-0.0015037148198782	88	20	0.00786472670074715	2543	6908	2564,81539,2785,2550,2782,9001,2773,5566,2783,2752,2770,2744,10681,11337,59345,115,2571,2771,5567,66008	GABRE,SLC38A1,GNG3,GABBR1,GNB1,HAP1,GNAI3,PRKACA,GNB2,GLUL,GNAI1,GLS,GNB5,GABARAP,GNB4,ADCY9,GAD1,GNAI2,PRKACB,TRAK2
ko04713	Circadian entrainment	0.998562353179195	-0.00143868122652181	95	22	0.00865119937082186	2543	6908	8913,2785,808,2782,51655,3710,2773,5566,9252,2783,5595,2770,2778,817,10681,59345,5187,115,3708,2771,5594,5567	CACNA1G,GNG3,CALM3,GNB1,RASD1,ITPR3,GNAI3,PRKACA,RPS6KA5,GNB2,MAPK3,GNAI1,GNAS,CAMK2D,GNB5,GNB4,PER1,ADCY9,ITPR1,GNAI2,MAPK1,PRKACB
hsa04713	Circadian entrainment	0.998562353179195	-0.00143868122652181	95	22	0.00865119937082186	2543	6908	8913,2785,808,2782,51655,3710,2773,5566,9252,2783,5595,2770,2778,817,10681,59345,5187,115,3708,2771,5594,5567	CACNA1G,GNG3,CALM3,GNB1,RASD1,ITPR3,GNAI3,PRKACA,RPS6KA5,GNB2,MAPK3,GNAI1,GNAS,CAMK2D,GNB5,GNB4,PER1,ADCY9,ITPR1,GNAI2,MAPK1,PRKACB
hsa05140	Leishmaniasis	0.998936415049224	-0.00106415095861732	72	15	0.00589854502556036	2543	6908	3592,5743,1535,23118,5777,51135,3688,65108,3717,3459,4793,10454,5970,5594,5595	IL12A,PTGS2,CYBA,TAB2,PTPN6,IRAK4,ITGB1,MARCKSL1,JAK2,IFNGR1,NFKBIB,TAB1,RELA,MAPK1,MAPK3
ko05140	Leishmaniasis	0.998936415049224	-0.00106415095861732	72	15	0.00589854502556036	2543	6908	3592,5743,1535,23118,5777,51135,3688,65108,3717,3459,4793,10454,5970,5594,5595	IL12A,PTGS2,CYBA,TAB2,PTPN6,IRAK4,ITGB1,MARCKSL1,JAK2,IFNGR1,NFKBIB,TAB1,RELA,MAPK1,MAPK3
hsa04913	Ovarian steroidogenesis	0.998940242735211	-0.00106031920456749	50	9	0.00353912701533622	2543	6908	2778,5743,3643,115,5566,654,5567,2661,1545	GNAS,PTGS2,INSR,ADCY9,PRKACA,BMP6,PRKACB,GDF9,CYP1B1
ko04913	Ovarian steroidogenesis	0.998940242735211	-0.00106031920456749	50	9	0.00353912701533622	2543	6908	2778,5743,3643,115,5566,654,5567,2661,1545	GNAS,PTGS2,INSR,ADCY9,PRKACA,BMP6,PRKACB,GDF9,CYP1B1
hsa04151	PI3K-Akt signaling pathway	0.999093511929039	-0.000906899179734839	346	101	0.0397168698387731	2543	6908	100533105,7249,2475,2785,5894,5879,6256,5604,5520,2782,1147,598,1026,7531,2783,23566,898,5519,57521,4193,3551,5296,1289,6194,1027,8503,5521,1386,5970,1977,1021,64223,6655,468,207,208,3326,842,2257,10971,672,7422,6009,2260,7532,5529,1969,1945,59345,1978,3673,3688,5590,4254,2932,5527,6198,5594,5528,9170,1388,5562,10488,3693,2309,54541,7057,5586,10681,896,117145,1291,6446,3913,3717,3320,5106,10018,6199,7423,5170,3915,6654,3164,5295,3678,5747,3454,92579,5605,5595,2885,3643,29941,3569,7060,7534,3685,1288,7533,3265	C8orf44-SGK3,TSC2,MTOR,GNG3,RAF1,RAC1,RXRA,MAP2K1,PPP2R2A,GNB1,CHUK,BCL2L1,CDKN1A,YWHAE,GNB2,LPAR3,CCNE1,PPP2R1B,RPTOR,MDM2,IKBKB,PIK3R2,COL5A1,RPS6,CDKN1B,PIK3R3,PPP2R2B,ATF2,RELA,EIF4E,CDK6,MLST8,SOS2,ATF4,AKT1,AKT2,HSP90AB1,CASP9,FGF12,YWHAQ,BRCA1,VEGFA,RHEB,FGFR1,YWHAG,PPP2R5E,EPHA2,EFNA4,GNB4,EIF4EBP1,ITGA2,ITGB1,PRKCZ,KITLG,GSK3B,PPP2R5C,RPS6KB1,MAPK1,PPP2R5D,LPAR2,ATF6B,PRKAA1,CREB3,ITGB5,FOXO3,DDIT4,THBS1,PKN2,GNB5,CCND3,THEM4,COL6A1,SGK1,LAMB2,JAK2,HSP90AA1,PCK2,BCL2L11,RPS6KB2,VEGFB,PDPK1,LAMC1,SOS1,NR4A1,PIK3R1,ITGA5,PTK2,IFNAR1,G6PC3,MAP2K2,MAPK3,GRB2,INSR,PKN3,IL6,THBS4,YWHAZ,ITGAV,COL4A6,YWHAH,HRAS
ko04151	PI3K-Akt signaling pathway	0.999093511929039	-0.000906899179734839	346	101	0.0397168698387731	2543	6908	100533105,7249,2475,2785,5894,5879,6256,5604,5520,2782,1147,598,1026,7531,2783,23566,898,5519,57521,4193,3551,5296,1289,6194,1027,8503,5521,1386,5970,1977,1021,64223,6655,468,207,208,3326,842,2257,10971,672,7422,6009,2260,7532,5529,1969,1945,59345,1978,3673,3688,5590,4254,2932,5527,6198,5594,5528,9170,1388,5562,10488,3693,2309,54541,7057,5586,10681,896,117145,1291,6446,3913,3717,3320,5106,10018,6199,7423,5170,3915,6654,3164,5295,3678,5747,3454,92579,5605,5595,2885,3643,29941,3569,7060,7534,3685,1288,7533,3265	C8orf44-SGK3,TSC2,MTOR,GNG3,RAF1,RAC1,RXRA,MAP2K1,PPP2R2A,GNB1,CHUK,BCL2L1,CDKN1A,YWHAE,GNB2,LPAR3,CCNE1,PPP2R1B,RPTOR,MDM2,IKBKB,PIK3R2,COL5A1,RPS6,CDKN1B,PIK3R3,PPP2R2B,ATF2,RELA,EIF4E,CDK6,MLST8,SOS2,ATF4,AKT1,AKT2,HSP90AB1,CASP9,FGF12,YWHAQ,BRCA1,VEGFA,RHEB,FGFR1,YWHAG,PPP2R5E,EPHA2,EFNA4,GNB4,EIF4EBP1,ITGA2,ITGB1,PRKCZ,KITLG,GSK3B,PPP2R5C,RPS6KB1,MAPK1,PPP2R5D,LPAR2,ATF6B,PRKAA1,CREB3,ITGB5,FOXO3,DDIT4,THBS1,PKN2,GNB5,CCND3,THEM4,COL6A1,SGK1,LAMB2,JAK2,HSP90AA1,PCK2,BCL2L11,RPS6KB2,VEGFB,PDPK1,LAMC1,SOS1,NR4A1,PIK3R1,ITGA5,PTK2,IFNAR1,G6PC3,MAP2K2,MAPK3,GRB2,INSR,PKN3,IL6,THBS4,YWHAZ,ITGAV,COL4A6,YWHAH,HRAS
ko04723	Retrograde endocannabinoid signaling	0.999201469271228	-0.000798849724264031	101	23	0.00904443570585922	2543	6908	5599,2564,2785,2782,3709,3710,2773,5566,57406,222236,2783,5595,2770,5743,10681,221955,59345,115,5601,3708,2771,5594,5567	MAPK8,GABRE,GNG3,GNB1,ITPR2,ITPR3,GNAI3,PRKACA,ABHD6,NAPEPLD,GNB2,MAPK3,GNAI1,PTGS2,GNB5,DAGLB,GNB4,ADCY9,MAPK9,ITPR1,GNAI2,MAPK1,PRKACB
hsa04723	Retrograde endocannabinoid signaling	0.999201469271228	-0.000798849724264031	101	23	0.00904443570585922	2543	6908	5599,2564,2785,2782,3709,3710,2773,5566,57406,222236,2783,5595,2770,5743,10681,221955,59345,115,5601,3708,2771,5594,5567	MAPK8,GABRE,GNG3,GNB1,ITPR2,ITPR3,GNAI3,PRKACA,ABHD6,NAPEPLD,GNB2,MAPK3,GNAI1,PTGS2,GNB5,DAGLB,GNB4,ADCY9,MAPK9,ITPR1,GNAI2,MAPK1,PRKACB
hsa00053	Ascorbate and aldarate metabolism	0.999448078375959	-0.000552073988845687	27	3	0.00117970900511207	2543	6908	224,7358,223	ALDH3A2,UGDH,ALDH9A1
ko00053	Ascorbate and aldarate metabolism	0.999448078375959	-0.000552073988845687	27	3	0.00117970900511207	2543	6908	224,7358,223	ALDH3A2,UGDH,ALDH9A1
hsa04976	Bile secretion	0.999464334458563	-0.000535809061477664	71	14	0.005505308690523	2543	6908	2778,476,8671,6256,115,9429,6548,482,6522,481,5566,5567,3156,2052	GNAS,ATP1A1,SLC4A4,RXRA,ADCY9,ABCG2,SLC9A1,ATP1B2,SLC4A2,ATP1B1,PRKACA,PRKACB,HMGCR,EPHX1
ko04976	Bile secretion	0.999464334458563	-0.000535809061477664	71	14	0.005505308690523	2543	6908	2778,476,8671,6256,115,9429,6548,482,6522,481,5566,5567,3156,2052	GNAS,ATP1A1,SLC4A4,RXRA,ADCY9,ABCG2,SLC9A1,ATP1B2,SLC4A2,ATP1B1,PRKACA,PRKACB,HMGCR,EPHX1
hsa05146	Amoebiasis	0.999558100373446	-0.00044199729296791	107	24	0.00943767204089658	2543	6908	836,3915,7879,5295,5868,87,5747,5869,5566,2767,2778,3592,3569,1289,5296,81,8503,3913,5269,1288,5970,7414,5878,5567	CASP3,LAMC1,RAB7A,PIK3R1,RAB5A,ACTN1,PTK2,RAB5B,PRKACA,GNA11,GNAS,IL12A,IL6,COL5A1,PIK3R2,ACTN4,PIK3R3,LAMB2,SERPINB6,COL4A6,RELA,VCL,RAB5C,PRKACB
ko05146	Amoebiasis	0.999558100373446	-0.00044199729296791	107	24	0.00943767204089658	2543	6908	836,3915,7879,5295,5868,87,5747,5869,5566,2767,2778,3592,3569,1289,5296,81,8503,3913,5269,1288,5970,7414,5878,5567	CASP3,LAMC1,RAB7A,PIK3R1,RAB5A,ACTN1,PTK2,RAB5B,PRKACA,GNA11,GNAS,IL12A,IL6,COL5A1,PIK3R2,ACTN4,PIK3R3,LAMB2,SERPINB6,COL4A6,RELA,VCL,RAB5C,PRKACB
hsa05144	Malaria	0.999564153244789	-0.000435941764014946	49	8	0.00314589068029886	2543	6908	3592,3569,7060,4035,3606,958,6382,7057	IL12A,IL6,THBS4,LRP1,IL18,CD40,SDC1,THBS1
ko05144	Malaria	0.999564153244789	-0.000435941764014946	49	8	0.00314589068029886	2543	6908	3592,3569,7060,4035,3606,958,6382,7057	IL12A,IL6,THBS4,LRP1,IL18,CD40,SDC1,THBS1
hsa00590	Arachidonic acid metabolism	0.999710344700579	-0.000289697257619385	62	11	0.00432559968541093	2543	6908	5743,127281,6916,81579,113612,10728,11145,2876,9536,8398,493869	PTGS2,FAM213B,TBXAS1,PLA2G12A,CYP2U1,PTGES3,PLA2G16,GPX1,PTGES,PLA2G6,GPX8
ko00590	Arachidonic acid metabolism	0.999710344700579	-0.000289697257619385	62	11	0.00432559968541093	2543	6908	5743,127281,6916,81579,113612,10728,11145,2876,9536,8398,493869	PTGS2,FAM213B,TBXAS1,PLA2G12A,CYP2U1,PTGES3,PLA2G16,GPX1,PTGES,PLA2G6,GPX8
hsa00591	Linoleic acid metabolism	0.999748412180993	-0.000251619472531275	29	3	0.00117970900511207	2543	6908	81579,11145,8398	PLA2G12A,PLA2G16,PLA2G6
ko00591	Linoleic acid metabolism	0.999748412180993	-0.000251619472531275	29	3	0.00117970900511207	2543	6908	81579,11145,8398	PLA2G12A,PLA2G16,PLA2G6
hsa00980	Metabolism of xenobiotics by cytochrome P450	0.999764837505261	-0.000235190149774372	74	14	0.005505308690523	2543	6908	128,27294,373156,221,119391,2948,4259,29785,2952,4258,4257,8574,2052,1545	ADH5,DHDH,GSTK1,ALDH3B1,GSTO2,GSTM4,MGST3,CYP2S1,GSTT1,MGST2,MGST1,AKR7A2,EPHX1,CYP1B1
ko00980	Metabolism of xenobiotics by cytochrome P450	0.999764837505261	-0.000235190149774372	74	14	0.005505308690523	2543	6908	128,27294,373156,221,119391,2948,4259,29785,2952,4258,4257,8574,1545,2052	ADH5,DHDH,GSTK1,ALDH3B1,GSTO2,GSTM4,MGST3,CYP2S1,GSTT1,MGST2,MGST1,AKR7A2,CYP1B1,EPHX1
hsa04911	Insulin secretion	0.999766815703007	-0.000233211488678402	85	17	0.00668501769563508	2543	6908	2778,817,476,468,1388,115,3782,482,3767,6616,10488,481,3710,5566,1386,2767,5567	GNAS,CAMK2D,ATP1A1,ATF4,ATF6B,ADCY9,KCNN3,ATP1B2,KCNJ11,SNAP25,CREB3,ATP1B1,ITPR3,PRKACA,ATF2,GNA11,PRKACB
ko04742	Taste transduction	0.999770100198606	-0.000229926232404857	51	8	0.00314589068029886	2543	6908	2778,6337,2785,83756,2782,3710,5566,5567	GNAS,SCNN1A,GNG3,TAS1R3,GNB1,ITPR3,PRKACA,PRKACB
hsa04742	Taste transduction	0.999770100198606	-0.000229926232404857	51	8	0.00314589068029886	2543	6908	2778,6337,2785,83756,2782,3710,5566,5567	GNAS,SCNN1A,GNG3,TAS1R3,GNB1,ITPR3,PRKACA,PRKACB
ko05143	African trypanosomiasis	0.999774122946731	-0.000225902567332415	34	4	0.00157294534014943	2543	6908	3606,3592,3569,7064	IL18,IL12A,IL6,THOP1
hsa05143	African trypanosomiasis	0.999774122946731	-0.000225902567332415	34	4	0.00157294534014943	2543	6908	3606,3592,3569,7064	IL18,IL12A,IL6,THOP1
ko04672	Intestinal immune network for IgA production	0.999775915551161	-0.000224109559510755	47	7	0.0027526543452615	2543	6908	7852,23308,958,9020,3601,115650,3569	CXCR4,ICOSLG,CD40,MAP3K14,IL15RA,TNFRSF13C,IL6
hsa04672	Intestinal immune network for IgA production	0.999775915551161	-0.000224109559510755	47	7	0.0027526543452615	2543	6908	7852,23308,958,9020,3601,115650,3569	CXCR4,ICOSLG,CD40,MAP3K14,IL15RA,TNFRSF13C,IL6
hsa04726	Serotonergic synapse	0.999864640567681	-0.000135368594233754	112	24	0.00943767204089658	2543	6908	836,673,2785,5894,5604,2782,3709,3710,2773,5566,2783,5595,2770,2778,5743,10681,59345,3708,7220,2771,5594,3265,5567,1843	CASP3,BRAF,GNG3,RAF1,MAP2K1,GNB1,ITPR2,ITPR3,GNAI3,PRKACA,GNB2,MAPK3,GNAI1,GNAS,PTGS2,GNB5,GNB4,ITPR1,TRPC1,GNAI2,MAPK1,HRAS,PRKACB,DUSP1
hsa04950	Maturity onset diabetes of the young	0.999896502767697	-0.000103502588511473	26	2	0.000786472670074715	2543	6908	3280,3087	HES1,HHEX
ko04950	Maturity onset diabetes of the young	0.999896502767697	-0.000103502588511473	26	2	0.000786472670074715	2543	6908	3280,3087	HES1,HHEX
hsa05204	Chemical carcinogenesis	0.999906129608656	-9.38747974453787e-05	81	15	0.00589854502556036	2543	6908	128,373156,5743,221,883,119391,9,4259,2948,2952,56267,4258,4257,2052,1545	ADH5,GSTK1,PTGS2,ALDH3B1,CCBL1,GSTO2,NAT1,MGST3,GSTM4,GSTT1,CCBL2,MGST2,MGST1,EPHX1,CYP1B1
ko05204	Chemical carcinogenesis	0.999906129608656	-9.38747974453787e-05	81	15	0.00589854502556036	2543	6908	128,373156,5743,221,883,119391,9,4259,2948,2952,56267,4258,4257,2052,1545	ADH5,GSTK1,PTGS2,ALDH3B1,CCBL1,GSTO2,NAT1,MGST3,GSTM4,GSTT1,CCBL2,MGST2,MGST1,EPHX1,CYP1B1
hsa04512	ECM-receptor interaction	0.999950361805775	-4.96394262410931e-05	87	16	0.00629178136059772	2543	6908	3915,3678,2812,3693,6382,1605,7057,7060,1289,1291,961,3673,3688,3913,3685,1288	LAMC1,ITGA5,GP1BB,ITGB5,SDC1,DAG1,THBS1,THBS4,COL5A1,COL6A1,CD47,ITGA2,ITGB1,LAMB2,ITGAV,COL4A6
ko04512	ECM-receptor interaction	0.999950361805775	-4.96394262410931e-05	87	16	0.00629178136059772	2543	6908	3915,3678,2812,3693,6382,1605,7057,7060,1289,1291,961,3673,3688,3913,3685,1288	LAMC1,ITGA5,GP1BB,ITGB5,SDC1,DAG1,THBS1,THBS4,COL5A1,COL6A1,CD47,ITGA2,ITGB1,LAMB2,ITGAV,COL4A6
ko04744	Phototransduction	0.9999558734607	-4.41275129039113e-05	28	2	0.000786472670074715	2543	6908	808,2782	CALM3,GNB1
hsa04744	Phototransduction	0.9999558734607	-4.41275129039113e-05	28	2	0.000786472670074715	2543	6908	808,2782	CALM3,GNB1
hsa04940	Type I diabetes mellitus	0.999956484541486	-4.35164053387065e-05	43	5	0.00196618167518679	2543	6908	3592,3382,3329,2571,3105	IL12A,ICA1,HSPD1,GAD1,HLA-A
ko04940	Type I diabetes mellitus	0.999956484541486	-4.35164053387065e-05	43	5	0.00196618167518679	2543	6908	3592,3382,3329,2571,3105	IL12A,ICA1,HSPD1,GAD1,HLA-A
hsa00830	Retinol metabolism	0.999965773797999	-3.42267877306242e-05	65	10	0.00393236335037357	2543	6908	128,728635,54884,317749,29785,8694,8228,9249,1592,51109	ADH5,DHRS4L1,RETSAT,DHRS4L2,CYP2S1,DGAT1,PNPLA4,DHRS3,CYP26A1,RDH11
ko05321	Inflammatory bowel disease (IBD)	0.999965773797999	-3.42267877306242e-05	65	10	0.00393236335037357	2543	6908	4088,3592,4087,3569,6778,3606,3459,5970,6774,8809	SMAD3,IL12A,SMAD2,IL6,STAT6,IL18,IFNGR1,RELA,STAT3,IL18R1
ko00830	Retinol metabolism	0.999965773797999	-3.42267877306242e-05	65	10	0.00393236335037357	2543	6908	128,728635,54884,317749,29785,8694,8228,9249,1592,51109	ADH5,DHRS4L1,RETSAT,DHRS4L2,CYP2S1,DGAT1,PNPLA4,DHRS3,CYP26A1,RDH11
hsa05321	Inflammatory bowel disease (IBD)	0.999965773797999	-3.42267877306242e-05	65	10	0.00393236335037357	2543	6908	4088,3592,4087,3569,6778,3606,3459,5970,6774,8809	SMAD3,IL12A,SMAD2,IL6,STAT6,IL18,IFNGR1,RELA,STAT3,IL18R1
ko04970	Salivary secretion	0.999971859244568	-2.81411513901213e-05	89	16	0.00629178136059772	2543	6908	808,6522,3709,154,481,3710,5566,2778,476,115,3708,6548,482,6558,493,5567	CALM3,SLC4A2,ITPR2,ADRB2,ATP1B1,ITPR3,PRKACA,GNAS,ATP1A1,ADCY9,ITPR1,SLC9A1,ATP1B2,SLC12A2,ATP2B4,PRKACB
hsa05323	Rheumatoid arthritis	0.999971859244568	-2.81411513901213e-05	89	16	0.00629178136059772	2543	6908	523,537,535,3606,7422,51382,10312,3569,23545,527,51606,528,529,9114,8992,9550	ATP6V1A,ATP6AP1,ATP6V0A1,IL18,VEGFA,ATP6V1D,TCIRG1,IL6,ATP6V0A2,ATP6V0C,ATP6V1H,ATP6V1C1,ATP6V1E1,ATP6V0D1,ATP6V0E1,ATP6V1G1
ko05323	Rheumatoid arthritis	0.999971859244568	-2.81411513901213e-05	89	16	0.00629178136059772	2543	6908	523,537,535,3606,7422,51382,10312,3569,23545,527,51606,528,529,9114,8992,9550	ATP6V1A,ATP6AP1,ATP6V0A1,IL18,VEGFA,ATP6V1D,TCIRG1,IL6,ATP6V0A2,ATP6V0C,ATP6V1H,ATP6V1C1,ATP6V1E1,ATP6V0D1,ATP6V0E1,ATP6V1G1
hsa04970	Salivary secretion	0.999971859244568	-2.81411513901213e-05	89	16	0.00629178136059772	2543	6908	808,6522,3709,154,481,3710,5566,2778,476,115,3708,6548,482,6558,493,5567	CALM3,SLC4A2,ITPR2,ADRB2,ATP1B1,ITPR3,PRKACA,GNAS,ATP1A1,ADCY9,ITPR1,SLC9A1,ATP1B2,SLC12A2,ATP2B4,PRKACB
hsa05330	Allograft rejection	0.999989977244055	-1.00228061730549e-05	37	3	0.00117970900511207	2543	6908	3592,958,3105	IL12A,CD40,HLA-A
ko05330	Allograft rejection	0.999989977244055	-1.00228061730549e-05	37	3	0.00117970900511207	2543	6908	3592,958,3105	IL12A,CD40,HLA-A
ko05206	MicroRNAs in cancer	0.999994531364298	-5.46865065500318e-06	297	75	0.0294927251278018	2543	6908	1591,2033,836,2475,5894,4194,5604,2064,324,1026,898,599,1399,57521,1387,4193,6464,8651,3551,5296,1027,4082,1021,1545,23411,578,6655,1871,7430,672,6659,7422,995,2744,8660,6541,5743,5335,1398,9759,3065,6093,7168,1870,5594,659,11186,9252,10298,54541,2146,7057,25,5581,5292,2065,5598,10018,6774,10253,993,387,6654,7976,3678,900,5605,2885,6624,113130,23405,5268,3190,3265,1029	CYP24A1,EP300,CASP3,MTOR,RAF1,MDM4,MAP2K1,ERBB2,APC,CDKN1A,CCNE1,BCL2L2,CRKL,RPTOR,CREBBP,MDM2,SHC1,SOCS1,IKBKB,PIK3R2,CDKN1B,MARCKS,CDK6,CYP1B1,SIRT1,BAK1,SOS2,E2F3,EZR,BRCA1,SOX4,VEGFA,CDC25C,GLS,IRS2,SLC7A1,PTGS2,PLCG1,CRK,HDAC4,HDAC1,ROCK1,TPM1,E2F2,MAPK1,BMPR2,RASSF1,RPS6KA5,PAK4,DDIT4,EZH2,THBS1,ABL1,PRKCE,PIM1,ERBB3,MAPK7,BCL2L11,STAT3,SPRY2,CDC25A,RHOA,SOS1,FZD3,ITGA5,CCNG1,MAP2K2,GRB2,FSCN1,CDCA5,DICER1,SERPINB5,HNRNPK,HRAS,CDKN2A
hsa05206	MicroRNAs in cancer	0.999994531364298	-5.46865065500318e-06	297	75	0.0294927251278018	2543	6908	1591,2033,836,2475,5894,4194,5604,2064,324,1026,898,599,1399,57521,1387,4193,6464,8651,3551,5296,1027,4082,1021,1545,23411,578,6655,1871,7430,672,6659,7422,995,2744,8660,6541,5743,5335,1398,9759,3065,6093,7168,1870,5594,659,11186,9252,10298,54541,2146,7057,25,5581,5292,2065,5598,10018,6774,10253,993,387,6654,7976,3678,900,5605,2885,6624,113130,23405,5268,3190,3265,1029	CYP24A1,EP300,CASP3,MTOR,RAF1,MDM4,MAP2K1,ERBB2,APC,CDKN1A,CCNE1,BCL2L2,CRKL,RPTOR,CREBBP,MDM2,SHC1,SOCS1,IKBKB,PIK3R2,CDKN1B,MARCKS,CDK6,CYP1B1,SIRT1,BAK1,SOS2,E2F3,EZR,BRCA1,SOX4,VEGFA,CDC25C,GLS,IRS2,SLC7A1,PTGS2,PLCG1,CRK,HDAC4,HDAC1,ROCK1,TPM1,E2F2,MAPK1,BMPR2,RASSF1,RPS6KA5,PAK4,DDIT4,EZH2,THBS1,ABL1,PRKCE,PIM1,ERBB3,MAPK7,BCL2L11,STAT3,SPRY2,CDC25A,RHOA,SOS1,FZD3,ITGA5,CCNG1,MAP2K2,GRB2,FSCN1,CDCA5,DICER1,SERPINB5,HNRNPK,HRAS,CDKN2A
ko00982	Drug metabolism - cytochrome P450	0.999996826809781	-3.17319525385719e-06	68	9	0.00353912701533622	2543	6908	128,373156,221,119391,2948,4259,2952,4258,4257	ADH5,GSTK1,ALDH3B1,GSTO2,GSTM4,MGST3,GSTT1,MGST2,MGST1
hsa00982	Drug metabolism - cytochrome P450	0.999996826809781	-3.17319525385719e-06	68	9	0.00353912701533622	2543	6908	128,373156,221,119391,2948,4259,2952,4258,4257	ADH5,GSTK1,ALDH3B1,GSTO2,GSTM4,MGST3,GSTT1,MGST2,MGST1
hsa04974	Protein digestion and absorption	0.99999722429207	-2.7757117818254e-06	89	14	0.005505308690523	2543	6908	476,6520,206358,8645,1291,1289,482,1294,481,6510,1288,6505,117247,1303	ATP1A1,SLC3A2,SLC36A1,KCNK5,COL6A1,COL5A1,ATP1B2,COL7A1,ATP1B1,SLC1A5,COL4A6,SLC1A1,SLC16A10,COL12A1
ko04974	Protein digestion and absorption	0.99999722429207	-2.7757117818254e-06	89	14	0.005505308690523	2543	6908	476,6520,206358,8645,1291,1289,482,1294,481,6510,1288,6505,117247,1303	ATP1A1,SLC3A2,SLC36A1,KCNK5,COL6A1,COL5A1,ATP1B2,COL7A1,ATP1B1,SLC1A5,COL4A6,SLC1A1,SLC16A10,COL12A1
ko04020	Calcium signaling pathway	0.999998264448955	-1.73555255102638e-06	179	38	0.0149429807314196	2543	6908	8877,2064,808,814,5532,3709,5566,6869,488,6786,5255,115,7419,84876,57620,2065,5256,5261,5567,10105,8913,7417,154,7416,3710,2767,2778,5335,817,291,3708,5534,2185,5533,3706,56848,493,3269	SPHK1,ERBB2,CALM3,CAMK4,PPP3CB,ITPR2,PRKACA,TACR1,ATP2A2,STIM1,PHKA1,ADCY9,VDAC3,ORAI1,STIM2,ERBB3,PHKA2,PHKG2,PRKACB,PPIF,CACNA1G,VDAC2,ADRB2,VDAC1,ITPR3,GNA11,GNAS,PLCG1,CAMK2D,SLC25A4,ITPR1,PPP3R1,PTK2B,PPP3CC,ITPKA,SPHK2,ATP2B4,HRH1
hsa04020	Calcium signaling pathway	0.999998264448955	-1.73555255102638e-06	179	38	0.0149429807314196	2543	6908	8877,2064,808,814,5532,3709,5566,6869,488,5255,6786,115,84876,7419,57620,2065,5256,5261,5567,10105,8913,7417,154,7416,3710,2767,2778,5335,817,291,3708,5534,2185,5533,3706,56848,493,3269	SPHK1,ERBB2,CALM3,CAMK4,PPP3CB,ITPR2,PRKACA,TACR1,ATP2A2,PHKA1,STIM1,ADCY9,ORAI1,VDAC3,STIM2,ERBB3,PHKA2,PHKG2,PRKACB,PPIF,CACNA1G,VDAC2,ADRB2,VDAC1,ITPR3,GNA11,GNAS,PLCG1,CAMK2D,SLC25A4,ITPR1,PPP3R1,PTK2B,PPP3CC,ITPKA,SPHK2,ATP2B4,HRH1
hsa05310	Asthma	0.999998993187187	-1.00681331965126e-06	30	1	0.000393236335037357	2543	6908	958	CD40
ko05310	Asthma	0.999998993187187	-1.00681331965126e-06	30	1	0.000393236335037357	2543	6908	958	CD40
ko05332	Graft-versus-host disease	0.99999984318267	-1.56817341820911e-07	41	2	0.000786472670074715	2543	6908	3569,3105	IL6,HLA-A
hsa05332	Graft-versus-host disease	0.99999984318267	-1.56817341820911e-07	41	2	0.000786472670074715	2543	6908	3569,3105	IL6,HLA-A
ko04640	Hematopoietic cell lineage	0.999999981288316	-1.87116844818445e-08	87	10	0.00393236335037357	2543	6908	966,100133941,3590,3569,3673,3678,2812,4254,2323,7037	CD59,CD24,IL11RA,IL6,ITGA2,ITGA5,GP1BB,KITLG,FLT3LG,TFRC
hsa04640	Hematopoietic cell lineage	0.999999981288316	-1.87116844818445e-08	87	10	0.00393236335037357	2543	6908	966,100133941,3590,3569,3673,3678,2812,4254,2323,7037	CD59,CD24,IL11RA,IL6,ITGA2,ITGA5,GP1BB,KITLG,FLT3LG,TFRC
ko05033	Nicotine addiction	0.999999990128274	-9.87172641241084e-09	40	1	0.000393236335037357	2543	6908	2564	GABRE
hsa05033	Nicotine addiction	0.999999990128274	-9.87172641241084e-09	40	1	0.000393236335037357	2543	6908	2564	GABRE
hsa05150	Staphylococcus aureus infection	0.999999994787534	-5.21246622967994e-09	55	3	0.00117970900511207	2543	6908	715,717,1675	C1R,C2,CFD
ko05150	Staphylococcus aureus infection	0.999999994787534	-5.21246622967994e-09	55	3	0.00117970900511207	2543	6908	715,717,1675	C1R,C2,CFD
ko04610	Complement and coagulation cascades	0.999999998348159	-1.65184074698732e-09	69	5	0.00196618167518679	2543	6908	966,715,717,1675,2152	CD59,C1R,C2,CFD,F3
hsa04610	Complement and coagulation cascades	0.999999998348159	-1.65184074698732e-09	69	5	0.00196618167518679	2543	6908	966,715,717,1675,2152	CD59,C1R,C2,CFD,F3
hsa05320	Autoimmune thyroid disease	0.999999998822638	-1.1773620392073e-09	52	2	0.000786472670074715	2543	6908	958,3105	CD40,HLA-A
ko05320	Autoimmune thyroid disease	0.999999998822638	-1.1773620392073e-09	52	2	0.000786472670074715	2543	6908	958,3105	CD40,HLA-A
ko04514	Cell adhesion molecules (CAMs)	0.999999998878104	-1.12189557260256e-09	142	21	0.00825796303578451	2543	6908	9076,5817,9019,137075,5797,50848,29126,958,6382,214,3105,257194,4756,5792,90952,25945,2734,3688,3685,23308,1366	CLDN1,PVR,MPZL1,CLDN23,PTPRM,F11R,CD274,CD40,SDC1,ALCAM,HLA-A,NEGR1,NEO1,PTPRF,ESAM,PVRL3,GLG1,ITGB1,ITGAV,ICOSLG,CLDN7
hsa04514	Cell adhesion molecules (CAMs)	0.999999998878104	-1.12189557260256e-09	142	21	0.00825796303578451	2543	6908	9076,5817,9019,137075,5797,50848,29126,958,6382,214,3105,257194,4756,5792,90952,25945,2734,3688,3685,23308,1366	CLDN1,PVR,MPZL1,CLDN23,PTPRM,F11R,CD274,CD40,SDC1,ALCAM,HLA-A,NEGR1,NEO1,PTPRF,ESAM,PVRL3,GLG1,ITGB1,ITGAV,ICOSLG,CLDN7
hsa04740	Olfactory transduction	0.999999999888797	-1.11202990546875e-10	404	5	0.00196618167518679	2543	6908	808,817,5566,409,5567	CALM3,CAMK2D,PRKACA,ARRB2,PRKACB
ko04740	Olfactory transduction	0.999999999888797	-1.11202990546875e-10	404	5	0.00196618167518679	2543	6908	808,817,5566,409,5567	CALM3,CAMK2D,PRKACA,ARRB2,PRKACB
hsa04060	Cytokine-cytokine receptor interaction	0.999999999921491	-7.85089918998289e-11	265	39	0.0153362170664569	2543	6908	90,659,3601,2921,3597,3606,2920,55504,8809,8744,55540,3592,58191,3572,268,23765,92,1489,51330,970,3459,3588,3556,7423,3590,115650,23529,84957,8743,3454,2323,7422,958,3587,7852,3569,4254,657,8793	ACVR1,BMPR2,IL15RA,CXCL3,IL13RA1,IL18,CXCL2,TNFRSF19,IL18R1,TNFSF9,IL17RB,IL12A,CXCL16,IL6ST,AMH,IL17RA,ACVR2A,CTF1,TNFRSF12A,CD70,IFNGR1,IL10RB,IL1RAP,VEGFB,IL11RA,TNFRSF13C,CLCF1,RELT,TNFSF10,IFNAR1,FLT3LG,VEGFA,CD40,IL10RA,CXCR4,IL6,KITLG,BMPR1A,TNFRSF10D
ko04060	Cytokine-cytokine receptor interaction	0.999999999921491	-7.85089918998289e-11	265	39	0.0153362170664569	2543	6908	90,659,3601,2921,3597,3606,2920,55504,8809,8744,55540,3592,58191,3572,268,23765,92,1489,51330,970,3459,3588,3556,7423,3590,115650,23529,84957,8743,3454,2323,7422,958,3587,7852,3569,4254,657,8793	ACVR1,BMPR2,IL15RA,CXCL3,IL13RA1,IL18,CXCL2,TNFRSF19,IL18R1,TNFSF9,IL17RB,IL12A,CXCL16,IL6ST,AMH,IL17RA,ACVR2A,CTF1,TNFRSF12A,CD70,IFNGR1,IL10RB,IL1RAP,VEGFB,IL11RA,TNFRSF13C,CLCF1,RELT,TNFSF10,IFNAR1,FLT3LG,VEGFA,CD40,IL10RA,CXCR4,IL6,KITLG,BMPR1A,TNFRSF10D
ko04080	Neuroactive ligand-receptor interaction	0.999999999922273	-7.77271741434896e-11	276	20	0.00786472670074715	2543	6908	7068,9170,2564,53637,2908,2550,5734,154,23566,2918,6869,1138,57053,4157,706,4987,151,3269,339403,5029	THRB,LPAR2,GABRE,S1PR5,NR3C1,GABBR1,PTGER4,ADRB2,LPAR3,GRM8,TACR1,CHRNA5,CHRNA10,MC1R,TSPO,OPRL1,ADRA2B,HRH1,RXFP4,P2RY2
hsa04080	Neuroactive ligand-receptor interaction	0.999999999922273	-7.77271741434896e-11	276	20	0.00786472670074715	2543	6908	7068,9170,2564,53637,2908,2550,5734,154,23566,2918,6869,1138,57053,4157,706,4987,151,3269,339403,5029	THRB,LPAR2,GABRE,S1PR5,NR3C1,GABBR1,PTGER4,ADRB2,LPAR3,GRM8,TACR1,CHRNA5,CHRNA10,MC1R,TSPO,OPRL1,ADRA2B,HRH1,RXFP4,P2RY2
ko00140	Steroid hormone biosynthesis	0.999999999952659	-4.73413251622592e-11	58	2	0.000786472670074715	2543	6908	3291,1545	HSD11B2,CYP1B1
hsa00140	Steroid hormone biosynthesis	0.999999999952659	-4.73413251622592e-11	58	2	0.000786472670074715	2543	6908	3291,1545	HSD11B2,CYP1B1
hsa00472	D-Arginine and D-ornithine metabolism	1.00000000000596	5.95934412928045e-12	1	0	0	2543	6908
ko00472	D-Arginine and D-ornithine metabolism	1.00000000000596	5.95934412928045e-12	1	0	0	2543	6908