TermID	Term	Enrichment	logP	Genes in Term	Target Genes in Term	Fraction of Targets in Term	Total Target Genes	Total Genes	Entrez Gene IDs	Gene Symbols
pi3kciaktpathway	Class I PI3K signaling events mediated by Akt	2.08014290652764e-06	-13.0830739615498	34	28	0.0294736842105263	950	2227	5170,6517,4303,207,2931,2475,5591,5894,208,842,79109,10971,1147,1026,7531,5566,2309,7532,2932,1027,7534,253260,3320,4217,7533,9882,2810,64223	PDPK1,SLC2A4,FOXO4,AKT1,GSK3A,MTOR,PRKDC,RAF1,AKT2,CASP9,MAPKAP1,YWHAQ,CHUK,CDKN1A,YWHAE,PRKACA,FOXO3,YWHAG,GSK3B,CDKN1B,YWHAZ,RICTOR,HSP90AA1,MAP3K5,YWHAH,TBC1D4,SFN,MLST8
erbb1_downstream_pathway	ErbB1 downstream signaling	9.41849239742592e-06	-11.5728355249203	102	65	0.068421052631579	950	2227	5599,10163,5607,2475,5894,8826,5037,5879,10096,5604,5520,9712,81624,7531,55845,6194,8986,253260,10097,1386,64223,207,10971,5868,7532,378,5898,8976,5590,6722,5536,4086,5594,2549,673,1958,7410,5900,808,79109,10093,9252,824,466,10092,5601,6548,5598,6774,4214,1843,5170,6654,5295,5605,10458,5595,2885,7534,5337,10109,7533,6416,2810,6197	MAPK8,WASF2,MAP2K5,MTOR,RAF1,IQGAP1,PEBP1,RAC1,ACTR3,MAP2K1,PPP2R2A,USP6NL,DIAPH3,YWHAE,BRK1,RPS6,RPS6KA4,RICTOR,ACTR2,ATF2,MLST8,AKT1,YWHAQ,RAB5A,YWHAG,ARF4,RALA,WASL,PRKCZ,SRF,PPP5C,SMAD1,MAPK1,GAB1,BRAF,EGR1,VAV2,RALGDS,CALM3,MAPKAP1,ARPC4,RPS6KA5,CAPN2,ATF1,ARPC5,MAPK9,SLC9A1,MAPK7,STAT3,MAP3K1,DUSP1,PDPK1,SOS1,PIK3R1,MAP2K2,BAIAP2,MAPK3,GRB2,YWHAZ,PLD1,ARPC2,YWHAH,MAP2K4,SFN,RPS6KA3
cdc42_pathway	CDC42 signaling events	2.35414138895909e-05	-10.6567493946567	70	47	0.0494736842105263	950	2227	5599,673,2475,5894,8826,1495,5879,10096,7410,324,55740,10093,23265,81624,10298,5606,5581,1499,10092,5601,5062,1739,10097,1386,3985,4214,10188,5609,5295,7525,8476,9564,10458,5595,5608,3984,8976,396,4296,5590,2932,6198,5337,10109,5594,3265,6416	MAPK8,BRAF,MTOR,RAF1,IQGAP1,CTNNA1,RAC1,ACTR3,VAV2,APC,ENAH,ARPC4,EXOC7,DIAPH3,PAK4,MAP2K3,PRKCE,CTNNB1,ARPC5,MAPK9,PAK2,DLG1,ACTR2,ATF2,LIMK2,MAP3K1,TNK2,MAP2K7,PIK3R1,YES1,CDC42BPA,BCAR1,BAIAP2,MAPK3,MAP2K6,LIMK1,WASL,ARHGDIA,MAP3K11,PRKCZ,GSK3B,RPS6KB1,PLD1,ARPC2,MAPK1,HRAS,MAP2K4
hdac_classi_pathway	Signaling events mediated by HDAC Class I	5.65445836714366e-05	-9.78048113945107	66	44	0.0463157894736842	950	2227	2033,51547,161882,83933,25942,10013,5566,4084,7341,54815,1387,23381,2624,51564,8932,1108,5901,10419,6774,5970,8819,57459,23309,23411,5931,51548,5468,7024,9219,8841,5905,79084,53615,10014,5903,7514,9759,1107,3065,10284,9611,7528,57154,3066	EP300,SIRT7,ZFPM1,HDAC10,SIN3A,HDAC6,PRKACA,MXD1,SUMO1,GATAD2A,CREBBP,SMG5,GATA2,HDAC7,MBD2,CHD4,RAN,PRMT5,STAT3,RELA,SAP30,GATAD2B,SIN3B,SIRT1,RBBP7,SIRT6,PPARG,TFCP2,MTA2,HDAC3,RANGAP1,WDR77,MBD3,HDAC5,RANBP2,XPO1,HDAC4,CHD3,HDAC1,SAP18,NCOR1,YY1,SMURF1,HDAC2
met_pathway	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	0.00018379426171309	-8.60169356880704	72	46	0.0484210526315789	950	2227	5599,3636,1958,2475,1495,5894,5879,5604,324,2113,10298,30011,57521,1399,1499,5062,5781,1977,3837,4214,64223,5170,387,57610,207,6654,4690,6615,208,5295,5868,9564,5605,10048,5595,2885,5335,1398,8976,1978,382,5594,3265,6416,2549,8650	MAPK8,INPPL1,EGR1,MTOR,CTNNA1,RAF1,RAC1,MAP2K1,APC,ETS1,PAK4,SH3KBP1,RPTOR,CRKL,CTNNB1,PAK2,PTPN11,EIF4E,KPNB1,MAP3K1,MLST8,PDPK1,RHOA,RANBP10,AKT1,SOS1,NCK1,SNAI1,AKT2,PIK3R1,RAB5A,BCAR1,MAP2K2,RANBP9,MAPK3,GRB2,PLCG1,CRK,WASL,EIF4EBP1,ARF6,MAPK1,HRAS,MAP2K4,GAB1,NUMB
mtor_4pathway	mTOR signaling pathway	0.000339689257260571	-7.98747930749393	60	39	0.0410526315789474	950	2227	23291,673,7249,2475,5894,5879,5604,79109,7531,898,54541,57521,54700,1938,3551,6446,253260,664,1977,64223,5170,387,207,9821,10971,5605,6009,7532,5595,6249,1978,7534,6198,5337,7528,10891,7533,5594,2810	FBXW11,BRAF,TSC2,MTOR,RAF1,RAC1,MAP2K1,MAPKAP1,YWHAE,CCNE1,DDIT4,RPTOR,RRN3,EEF2,IKBKB,SGK1,RICTOR,BNIP3,EIF4E,MLST8,PDPK1,RHOA,AKT1,RB1CC1,YWHAQ,MAP2K2,RHEB,YWHAG,MAPK3,CLIP1,EIF4EBP1,YWHAZ,RPS6KB1,PLD1,YY1,PPARGC1A,YWHAH,MAPK1,SFN
p53regulationpathway	p53 pathway	0.000532545973989258	-7.53784132797738	59	38	0.04	950	2227	2033,5599,8493,1434,4194,11186,10524,1111,1452,6125,6135,25,1387,890,4193,9349,10075,387893,5601,7321,10419,1456,8445,84148,207,1454,6502,900,56950,91875,10155,64326,80204,1616,5524,2932,10848,7528	EP300,MAPK8,PPM1D,CSE1L,MDM4,RASSF1,KAT5,CHEK1,CSNK1A1,RPL5,RPL11,ABL1,CREBBP,CCNA2,MDM2,RPL23,HUWE1,KMT5A,MAPK9,UBE2D1,PRMT5,CSNK1G3,DYRK2,KAT8,AKT1,CSNK1E,SKP2,CCNG1,SMYD2,TTC5,TRIM28,RFWD2,FBXO11,DAXX,PPP2R4,GSK3B,PPP1R13L,YY1
e2f_pathway	E2F transcription factor network	0.00103967659764653	-6.86884557798954	72	44	0.0463157894736842	950	2227	2033,8936,1875,6240,1050,1026,898,1387,1031,26959,890,896,5902,1027,10419,6667,23429,1876,23411,993,6595,2648,11073,5422,8409,4605,1871,6241,990,672,10155,983,840,7030,1874,7027,1719,7298,3065,317,7528,7029,1870,4172	EP300,WASF1,E2F5,RRM1,CEBPA,CDKN1A,CCNE1,CREBBP,CDKN2C,HBP1,CCNA2,CCND3,RANBP1,CDKN1B,PRMT5,SP1,RYBP,E2F6,SIRT1,CDC25A,SMARCA2,KAT2A,TOPBP1,POLA1,UXT,MYBL2,E2F3,RRM2,CDC6,BRCA1,TRIM28,CDK1,CASP7,TFE3,E2F4,TFDP1,DHFR,TYMS,HDAC1,APAF1,YY1,TFDP2,E2F2,MCM3
smad2_3pathway	Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.00137393087578246	-6.59007939519389	19	15	0.0157894736842105	950	2227	51588,4088,4087,808,9972,5494,3838,5594,8021,4089,10106,3837,5595,4214,58190	PIAS4,SMAD3,SMAD2,CALM3,NUP153,PPM1A,KPNA2,MAPK1,NUP214,SMAD4,CTDSP2,KPNB1,MAPK3,MAP3K1,CTDSP1
foxopathway	FoxO family signaling	0.00162933466022572	-6.4195835314038	48	31	0.0326315789473684	950	2227	23411,2033,5599,4303,207,1454,6502,6648,10971,1147,7531,891,1452,7763,2309,7532,1387,847,7514,1647,1499,3551,5601,6446,1027,7534,5901,10018,7533,1456,2810	SIRT1,EP300,MAPK8,FOXO4,AKT1,CSNK1E,SKP2,SOD2,YWHAQ,CHUK,YWHAE,CCNB1,CSNK1A1,ZFAND5,FOXO3,YWHAG,CREBBP,CAT,XPO1,GADD45A,CTNNB1,IKBKB,MAPK9,SGK1,CDKN1B,YWHAZ,RAN,BCL2L11,YWHAH,CSNK1G3,SFN
telomerasepathway	Regulation of Telomerase	0.0021905644356814	-6.12359603517336	66	40	0.0421052631578947	950	2227	54984,5883,2475,641,25942,7531,8658,4084,25,54386,7337,23381,65057,26277,1027,4361,3320,10728,6667,8819,6670,23309,23293,5810,5931,207,3183,4691,1736,5595,7520,4088,3065,6198,10284,7026,5594,7013,3066,3659	PINX1,RAD9A,MTOR,BLM,SIN3A,YWHAE,TNKS,MXD1,ABL1,TERF2IP,UBE3A,SMG5,ACD,TINF2,CDKN1B,MRE11A,HSP90AA1,PTGES3,SP1,SAP30,SP3,SIN3B,SMG6,RAD1,RBBP7,AKT1,HNRNPC,NCL,DKC1,MAPK3,XRCC5,SMAD3,HDAC1,RPS6KB1,SAP18,NR2F2,MAPK1,TERF1,HDAC2,IRF1
ar_pathway	Coregulation of Androgen receptor activity	0.00300686913654843	-5.80685589552753	57	35	0.0368421052631579	950	2227	51588,4824,9039,5074,23028,5036,7337,23054,1499,6925,896,841,5469,8204,10106,1021,10498,7050,207,4117,5591,2274,3092,672,55818,26060,7520,10401,2934,8031,2185,6722,6197,7041,58190	PIAS4,NKX3-1,UBA3,PAWR,KDM1A,PA2G4,UBE3A,NCOA6,CTNNB1,TCF4,CCND3,CASP8,MED1,NRIP1,CTDSP2,CDK6,CARM1,TGIF1,AKT1,MAK,PRKDC,FHL2,HIP1,BRCA1,KDM3A,APPL1,XRCC5,PIAS3,GSN,NCOA4,PTK2B,SRF,RPS6KA3,TGFB1I1,CTDSP1
vegfr1_2_pathway	Signaling events mediated by VEGFR1 and VEGFR2	0.00317243208362834	-5.75325676644465	63	38	0.04	950	2227	2034,9175,8826,5879,808,5566,8828,5606,1499,6464,5781,3320,7414,10818,2242,7423,5170,387,207,4690,6654,5777,5295,7525,857,7422,5595,2885,5335,2534,3091,2185,3685,6093,8829,5594,3265,2549	EPAS1,MAP3K13,IQGAP1,RAC1,CALM3,PRKACA,NRP2,MAP2K3,CTNNB1,SHC1,PTPN11,HSP90AA1,VCL,FRS2,FES,VEGFB,PDPK1,RHOA,AKT1,NCK1,SOS1,PTPN6,PIK3R1,YES1,CAV1,VEGFA,MAPK3,GRB2,PLCG1,FYN,HIF1A,PTK2B,ITGAV,ROCK1,NRP1,MAPK1,HRAS,GAB1
myc_activpathway	Validated targets of C-MYC transcriptional activation	0.0032874414850102	-5.7176456808731	81	47	0.0494736842105263	950	2227	2033,8886,92140,3398,10524,9913,891,7037,6135,1387,11235,10075,5366,581,4831,3320,5292,3329,23089,1977,993,6881,2597,2648,6615,84864,1871,4691,6875,83879,4953,8464,7343,4088,1981,3658,3308,4830,1104,5757,1965,5274,3159,6883,57678,10856,4089	EP300,DDX18,MTDH,ID2,KAT5,SUPT7L,CCNB1,TFRC,RPL11,CREBBP,PDCD10,HUWE1,PMAIP1,BAX,NME2,HSP90AA1,PIM1,HSPD1,PEG10,EIF4E,CDC25A,TAF10,GAPDH,KAT2A,SNAI1,MINA,E2F3,NCL,TAF4B,CDCA7,ODC1,SUPT3H,UBTF,SMAD3,EIF4G1,IREB2,HSPA4,NME1,RCC1,PTMA,EIF2S1,SERPINI1,HMGA1,TAF12,GPAM,RUVBL2,SMAD4
vegfr1_pathway	VEGFR1 specific signals	0.00362299706747152	-5.62045367648948	29	20	0.0210526315789474	950	2227	5170,207,4690,5295,808,857,7422,5566,5921,8828,5595,5335,23607,3091,5781,3320,8829,5594,2549,7423	PDPK1,AKT1,NCK1,PIK3R1,CALM3,CAV1,VEGFA,PRKACA,RASA1,NRP2,MAPK3,PLCG1,CD2AP,HIF1A,PTPN11,HSP90AA1,NRP1,MAPK1,GAB1,VEGFB
plk1_pathway	PLK1 signaling events	0.00375427129780512	-5.58486107443466	44	28	0.0294736842105263	950	2227	23291,387,10112,4659,63967,991,54821,10735,5861,891,79866,995,983,79682,26271,3796,7465,8555,51343,5500,6790,147841,699,151648,3619,9475,7178,10726	FBXW11,RHOA,KIF20A,PPP1R12A,CLSPN,CDC20,ERCC6L,STAG2,RAB1A,CCNB1,BORA,CDC25C,CDK1,CENPU,FBXO5,KIF2A,WEE1,CDC14B,FZR1,PPP1CB,AURKA,SPC24,BUB1,SGOL1,INCENP,ROCK2,TPT1,NUDC
fak_pathway	Signaling events mediated by focal adhesion kinase	0.0043842024792136	-5.42974754445095	54	33	0.0347368421052632	950	2227	5599,23092,673,5894,5879,5604,23162,2113,3693,824,50807,5601,7414,9475,387,6237,6654,5295,3678,87,7525,9564,5921,2885,5335,2534,1398,8976,2886,3688,3685,5594,6416	MAPK8,ARHGAP26,BRAF,RAF1,RAC1,MAP2K1,MAPK8IP3,ETS1,ITGB5,CAPN2,ASAP1,MAPK9,VCL,ROCK2,RHOA,RRAS,SOS1,PIK3R1,ITGA5,ACTN1,YES1,BCAR1,RASA1,GRB2,PLCG1,FYN,CRK,WASL,GRB7,ITGB1,ITGAV,MAPK1,MAP2K4
erbb2erbb3pathway	ErbB2/ErbB3 signaling events	0.00472583292140774	-5.35471145390885	35	23	0.0242105263157895	950	2227	5599,207,6654,2475,5894,5295,9101,5604,2064,5532,5566,5605,5595,2885,6464,10193,5601,5781,3717,4776,2065,6774,5594	MAPK8,AKT1,SOS1,MTOR,RAF1,PIK3R1,USP8,MAP2K1,ERBB2,PPP3CB,PRKACA,MAP2K2,MAPK3,GRB2,SHC1,RNF41,MAPK9,PTPN11,JAK2,NFATC4,ERBB3,STAT3,MAPK1
s1p_s1p4_pathway	S1P4 pathway	0.00690930055907943	-4.97488686787726	14	11	0.0115789473684211	950	2227	2768,5335,387,53637,2781,2773,2771,10672,5594,5595,2770	GNA12,PLCG1,RHOA,S1PR5,GNAZ,GNAI3,GNAI2,GNA13,MAPK1,MAPK3,GNAI1
hdac_classii_pathway	Signaling events mediated by HDAC Class II	0.00749831845825788	-4.89307648914331	34	22	0.0231578947368421	950	2227	7280,2908,8841,8625,2782,814,5905,54880,83933,10013,7531,10014,7341,5903,7514,9759,2624,51564,6722,3320,5901,57763	TUBB2A,NR3C1,HDAC3,RFXANK,GNB1,CAMK4,RANGAP1,BCOR,HDAC10,HDAC6,YWHAE,HDAC5,SUMO1,RANBP2,XPO1,HDAC4,GATA2,HDAC7,SRF,HSP90AA1,RAN,ANKRA2
kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)	0.00947983507073726	-4.6585883604681	52	31	0.0326315789473684	950	2227	5170,5599,2241,161742,200734,207,6654,5777,5894,5295,5604,4067,2309,5605,5595,2885,1387,1399,8651,6464,4286,5781,2932,4254,6776,3717,6198,6774,3265,2549,6591	PDPK1,MAPK8,FER,SPRED1,SPRED2,AKT1,SOS1,PTPN6,RAF1,PIK3R1,MAP2K1,LYN,FOXO3,MAP2K2,MAPK3,GRB2,CREBBP,CRKL,SOCS1,SHC1,MITF,PTPN11,GSK3B,KITLG,STAT5A,JAK2,RPS6KB1,STAT3,HRAS,GAB1,SNAI2
rac1_pathway	RAC1 signaling pathway	0.00953491854474479	-4.65279458273029	54	32	0.0336842105263158	950	2227	5599,10163,10152,5609,8936,8826,1495,5879,10096,10093,8394,9564,10458,5606,55845,1499,1535,1398,10092,5608,3984,5601,5062,396,4296,6776,10097,10109,6774,1386,6416,4214	MAPK8,WASF2,ABI2,MAP2K7,WASF1,IQGAP1,CTNNA1,RAC1,ACTR3,ARPC4,PIP5K1A,BCAR1,BAIAP2,MAP2K3,BRK1,CTNNB1,CYBA,CRK,ARPC5,MAP2K6,LIMK1,MAPK9,PAK2,ARHGDIA,MAP3K11,STAT5A,ACTR2,ARPC2,STAT3,ATF2,MAP2K4,MAP3K1
ranbp2pathway	Sumoylation by RanBP2 regulates transcriptional repression	0.00965382481990078	-4.64040108776503	11	9	0.00947368421052632	950	2227	5903,7514,4193,9759,9063,3065,5905,5901,7341	RANBP2,XPO1,MDM2,HDAC4,PIAS2,HDAC1,RANGAP1,RAN,SUMO1
insulin_glucose_pathway	Insulin-mediated glucose transport	0.0105722813552043	-4.54951966935128	29	19	0.02	950	2227	6517,23433,207,208,10971,808,434,6810,7531,5501,7532,3643,5584,5590,2932,7534,7533,9882,2810	SLC2A4,RHOQ,AKT1,AKT2,YWHAQ,CALM3,ASIP,STX4,YWHAE,PPP1CC,YWHAG,INSR,PRKCI,PRKCZ,GSK3B,YWHAZ,YWHAH,TBC1D4,SFN
aurora_a_pathway	Aurora A signaling	0.0111960168824203	-4.49219719943257	31	20	0.0210526315789474	950	2227	1058,81565,207,9787,6867,672,9212,5566,5921,9793,4193,1647,51343,6790,2932,5901,5528,4946,10460,54998	CENPA,NDEL1,AKT1,DLGAP5,TACC1,BRCA1,AURKB,PRKACA,RASA1,CKAP5,MDM2,GADD45A,FZR1,AURKA,GSK3B,RAN,PPP2R5D,OAZ1,TACC3,AURKAIP1
s1p_s1p5_pathway	S1P5 pathway	0.0127577217344339	-4.36161856446514	8	7	0.00736842105263158	950	2227	2768,387,53637,2781,2771,2773,2770	GNA12,RHOA,S1PR5,GNAZ,GNAI2,GNAI3,GNAI1
insulin_pathway	Insulin Pathway	0.013347544481491	-4.31642284502452	43	26	0.0273684210526316	950	2227	5170,10580,23433,207,6654,4690,208,5786,5295,23265,857,2309,10640,5921,2885,3643,6464,1978,5781,5584,60412,5590,6446,6198,55770,3265	PDPK1,SORBS1,RHOQ,AKT1,SOS1,NCK1,AKT2,PTPRA,PIK3R1,EXOC7,CAV1,FOXO3,EXOC5,RASA1,GRB2,INSR,SHC1,EIF4EBP1,PTPN11,PRKCI,EXOC4,PRKCZ,SGK1,RPS6KB1,EXOC2,HRAS
nfat_3pathway	Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0137040348757664	-4.29006497303022	51	30	0.0315789473684211	950	2227	2033,5599,836,3164,10971,814,808,4209,7531,1452,8021,5566,7532,5595,1387,5581,7514,5601,5590,2932,3838,23523,7534,5901,5292,7533,3837,2810,4214,11261	EP300,MAPK8,CASP3,NR4A1,YWHAQ,CAMK4,CALM3,MEF2D,YWHAE,CSNK1A1,NUP214,PRKACA,YWHAG,MAPK3,CREBBP,PRKCE,XPO1,MAPK9,PRKCZ,GSK3B,KPNA2,CABIN1,YWHAZ,RAN,PIM1,YWHAH,KPNB1,SFN,MAP3K1,CHP1
arf6downstreampathway	Arf6 downstream pathway	0.0159790675096987	-4.13647569393246	15	11	0.0115789473684211	950	2227	9727,387,4830,5879,5337,375,382,8394,5594,8766,5595	RAB11FIP3,RHOA,NME1,RAC1,PLD1,ARF1,ARF6,PIP5K1A,MAPK1,RAB11A,MAPK3
igf1_pathway	IGF1 pathway	0.0167617929971286	-4.08865320891463	28	18	0.0189473684210526	950	2227	5170,207,6654,5894,5295,10399,7531,9564,1399,8660,2885,1398,6464,5590,5781,7534,6198,3265	PDPK1,AKT1,SOS1,RAF1,PIK3R1,GNB2L1,YWHAE,BCAR1,CRKL,IRS2,GRB2,CRK,SHC1,PRKCZ,PTPN11,YWHAZ,RPS6KB1,HRAS
wnt_noncanonical_pathway	Noncanonical Wnt signaling pathway	0.0174913863539512	-4.04604672757261	30	19	0.02	950	2227	5599,387,5468,5879,51701,1857,7525,2535,1452,8324,7474,23118,5601,5590,6093,409,10454,1856,9869	MAPK8,RHOA,PPARG,RAC1,NLK,DVL3,YES1,FZD2,CSNK1A1,FZD7,WNT5A,TAB2,MAPK9,PRKCZ,ROCK1,ARRB2,TAB1,DVL2,SETDB1
erbb4_pathway	ErbB4 signaling events	0.0180907747116883	-4.01235315508073	32	20	0.0210526315789474	950	2227	685,6868,83737,5295,1742,10413,2064,6777,5595,2885,4193,2534,6464,23118,2069,6776,11059,3717,9611,5594	BTC,ADAM17,ITCH,PIK3R1,DLG4,YAP1,ERBB2,STAT5B,MAPK3,GRB2,MDM2,FYN,SHC1,TAB2,EREG,STAT5A,WWP1,JAK2,NCOR1,MAPK1
ret_pathway	Signaling events regulated by Ret tyrosine kinase	0.019242700799343	-3.95062346940988	38	23	0.0242105263157895	950	2227	9260,5599,387,6654,4690,5295,5879,85358,9564,5566,5921,5595,2885,8660,5906,6464,1398,2886,5781,5594,3265,10818,2549	PDLIM7,MAPK8,RHOA,SOS1,NCK1,PIK3R1,RAC1,SHANK3,BCAR1,PRKACA,RASA1,MAPK3,GRB2,IRS2,RAP1A,SHC1,CRK,GRB7,PTPN11,MAPK1,HRAS,FRS2,GAB1
tnfpathway	TNF receptor signaling pathway	0.0196603282974988	-3.92915246564879	44	26	0.0273684210526316	950	2227	4215,23043,5871,6868,5609,7128,330,7186,117584,1147,10399,857,329,8439,5606,7185,11183,8878,8567,3551,5590,5584,4217,841,5970,4214	MAP3K3,TNIK,MAP4K2,ADAM17,MAP2K7,TNFAIP3,BIRC3,TRAF2,RFFL,CHUK,GNB2L1,CAV1,BIRC2,NSMAF,MAP2K3,TRAF1,MAP4K5,SQSTM1,MADD,IKBKB,PRKCZ,PRKCI,MAP3K5,CASP8,RELA,MAP3K1
hedgehog_glipathway	Hedgehog signaling events mediated by Gli proteins	0.0196603282974988	-3.92915246564879	44	26	0.0273684210526316	950	2227	23309,23291,5931,3958,207,1454,51715,5604,5727,26160,2782,27148,25942,1452,5566,1387,2737,7514,11127,3065,2932,10284,409,1456,3066,8819	SIN3B,FBXW11,RBBP7,LGALS3,AKT1,CSNK1E,RAB23,MAP2K1,PTCH1,IFT172,GNB1,STK36,SIN3A,CSNK1A1,PRKACA,CREBBP,GLI3,XPO1,KIF3A,HDAC1,GSK3B,SAP18,ARRB2,CSNK1G3,HDAC2,SAP30
p53downstreampathway	Direct p53 effectors	0.0215874866289509	-3.83564145489803	132	68	0.071578947368421	950	2227	2033,55367,7249,839,3732,94241,3276,1434,6890,6597,9518,324,1026,891,6273,1847,133746,599,54541,8812,1387,4193,5111,57103,5366,57060,51499,2232,581,7159,4801,6591,10498,6667,1843,3486,1263,578,1643,7832,7039,665,467,900,857,639,1820,27244,9540,3663,22943,64326,1907,1647,1969,54487,3064,50484,7027,10153,4802,5268,1655,317,8793,2876,2810,3066	EP300,PIDD1,TSC2,CASP6,CD82,TP53INP1,PRMT1,CSE1L,TAP1,SMARCA4,GDF15,APC,CDKN1A,CCNB1,S100A2,DUSP5,JMY,BCL2L2,DDIT4,CCNK,CREBBP,MDM2,PCNA,TIGAR,PMAIP1,PCBP4,TRIAP1,FDXR,BAX,TP53BP2,NFYB,SNAI2,CARM1,SP1,DUSP1,IGFBP3,PLK3,BAK1,DDB2,BTG2,TGFA,BNIP3L,ATF3,CCNG1,CAV1,PRDM1,ARID3A,SESN1,TP53I3,IRF5,DKK1,RFWD2,EDN2,GADD45A,EPHA2,DGCR8,HTT,RRM2B,TFDP1,CEBPZ,NFYC,SERPINB5,DDX5,APAF1,TNFRSF10D,GPX1,SFN,HDAC2
p38_mkk3_6pathway	p38 MAPK signaling pathway	0.0268900847749364	-3.61599765604972	29	18	0.0189473684210526	950	2227	4215,9344,7186,83605,5879,10912,808,9064,5606,1647,23118,5608,4616,4217,4294,10454,51347,4214	MAP3K3,TAOK2,TRAF2,CCM2,RAC1,GADD45G,CALM3,MAP3K6,MAP2K3,GADD45A,TAB2,MAP2K6,GADD45B,MAP3K5,MAP3K10,TAB1,TAOK3,MAP3K1
bard1pathway	BARD1 signaling events	0.0268900847749364	-3.61599765604972	29	18	0.0189473684210526	950	2227	7323,2130,2176,11073,5591,7332,2177,672,2189,2178,2175,580,898,7520,55120,5111,5888,4361	UBE2D3,EWSR1,FANCC,TOPBP1,PRKDC,UBE2L3,FANCD2,BRCA1,FANCG,FANCE,FANCA,BARD1,CCNE1,XRCC5,FANCL,PCNA,RAD51,MRE11A
ecadherin_nascentaj_pathway	E-cadherin signaling in the nascent adherens junction	0.0278717383330025	-3.58014206652336	33	20	0.0210526315789474	950	2227	10163,387,207,3728,8826,1495,5295,5879,7410,7082,55740,27252,4830,1499,1398,8907,1739,1500,2017,382	WASF2,RHOA,AKT1,JUP,IQGAP1,CTNNA1,PIK3R1,RAC1,VAV2,TJP1,ENAH,KLHL20,NME1,CTNNB1,CRK,AP1M1,DLG1,CTNND1,CTTN,ARF6
epopathway	EPO signaling pathway	0.0278717383330025	-3.58014206652336	33	20	0.0210526315789474	950	2227	5599,6654,5777,5295,7410,6777,598,4067,9021,2885,1399,8660,5335,5906,6464,5781,6776,3717,3265,2549	MAPK8,SOS1,PTPN6,PIK3R1,VAV2,STAT5B,BCL2L1,LYN,SOCS3,GRB2,CRKL,IRS2,PLCG1,RAP1A,SHC1,PTPN11,STAT5A,JAK2,HRAS,GAB1
hdac_classiii_pathway	Signaling events mediated by HDAC Class III	0.0283738928519353	-3.56228582237581	39	23	0.0242105263157895	950	2227	23411,2033,7280,4303,8367,51547,2274,3008,4209,1026,8368,2309,8360,3206,121504,8365,1387,8294,9759,8366,8364,581,10891	SIRT1,EP300,TUBB2A,FOXO4,HIST1H4E,SIRT7,FHL2,HIST1H1E,MEF2D,CDKN1A,HIST1H4L,FOXO3,HIST1H4D,HOXA10,HIST4H4,HIST1H4H,CREBBP,HIST1H4I,HDAC4,HIST1H4B,HIST1H4C,BAX,PPARGC1A
rb_1pathway	Regulation of retinoblastoma protein	0.0358739492911666	-3.32774389338236	56	31	0.0326315789473684	950	2227	23411,2033,6872,6908,5468,632,5894,8841,11016,6502,6597,1050,1026,898,25,1387,7343,4193,890,6046,1874,7027,5601,4286,3065,1027,1386,1487,6839,1052,8535	SIRT1,EP300,TAF1,TBP,PPARG,BGLAP,RAF1,HDAC3,ATF7,SKP2,SMARCA4,CEBPA,CDKN1A,CCNE1,ABL1,CREBBP,UBTF,MDM2,CCNA2,BRD2,E2F4,TFDP1,MAPK9,MITF,HDAC1,CDKN1B,ATF2,CTBP1,SUV39H1,CEBPD,CBX4
s1p_s1p1_pathway	S1P1 pathway	0.0363931263349338	-3.31337535912375	20	13	0.0136842105263158	950	2227	5335,5743,387,2781,5879,8877,3685,7422,2771,2773,5594,5595,2770	PLCG1,PTGS2,RHOA,GNAZ,RAC1,SPHK1,ITGAV,VEGFA,GNAI2,GNAI3,MAPK1,MAPK3,GNAI1
arf6_traffickingpathway	Arf6 trafficking events	0.0395580792091476	-3.22998532727021	44	25	0.0263157894736842	950	2227	274,6517,3728,1495,9341,23162,3831,23265,154,6382,10640,5898,966,9043,4830,1499,3673,1213,1785,3688,60412,1500,55770,5337,382	BIN1,SLC2A4,JUP,CTNNA1,VAMP3,MAPK8IP3,KLC1,EXOC7,ADRB2,SDC1,EXOC5,RALA,CD59,SPAG9,NME1,CTNNB1,ITGA2,CLTC,DNM2,ITGB1,EXOC4,CTNND1,EXOC2,PLD1,ARF6
lkb1_pathway	LKB1 signaling events	0.0400345144046165	-3.21801333680257	42	24	0.0252631578947368	950	2227	23387,7249,2475,92335,10971,6604,7430,7531,5566,7532,57521,114790,51765,5664,2932,7534,3320,150094,7533,2118,9024,4089,2810,64223	SIK3,TSC2,MTOR,STRADA,YWHAQ,SMARCD3,EZR,YWHAE,PRKACA,YWHAG,RPTOR,STK11IP,STK26,PSEN2,GSK3B,YWHAZ,HSP90AA1,SIK1,YWHAH,ETV4,BRSK2,SMAD4,SFN,MLST8
pi3kplctrkpathway	Trk receptor signaling mediated by PI3K and PLC-gamma	0.0411511561816845	-3.19050325549351	32	19	0.02	950	2227	5170,207,1958,6654,5295,10971,814,7531,2309,7532,2885,5335,6464,2932,6776,7534,7533,2549,2810	PDPK1,AKT1,EGR1,SOS1,PIK3R1,YWHAQ,CAMK4,YWHAE,FOXO3,YWHAG,GRB2,PLCG1,SHC1,GSK3B,STAT5A,YWHAZ,YWHAH,GAB1,SFN
tgfbrpathway	TGF-beta receptor signaling	0.0506709791671009	-2.98240193528591	51	28	0.0294736842105263	950	2227	5170,387,6654,83737,5520,10413,857,64750,7531,9372,2885,4088,4087,1499,1490,6464,1616,25805,23645,6711,54778,11059,6198,5499,57154,409,4089,11171	PDPK1,RHOA,SOS1,ITCH,PPP2R2A,YAP1,CAV1,SMURF2,YWHAE,ZFYVE9,GRB2,SMAD3,SMAD2,CTNNB1,CTGF,SHC1,DAXX,BAMBI,PPP1R15A,SPTBN1,RNF111,WWP1,RPS6KB1,PPP1CA,SMURF1,ARRB2,SMAD4,STRAP
ecadherin_keratinocyte_pathway	E-cadherin signaling in keratinocytes	0.0576480048014772	-2.85339964168683	19	12	0.0126315789473684	950	2227	5335,7791,387,2534,7408,207,1495,208,5295,5879,1500,8394	PLCG1,ZYX,RHOA,FYN,VASP,AKT1,CTNNA1,AKT2,PIK3R1,RAC1,CTNND1,PIP5K1A
a6b1_a6b4_integrin_pathway	a6b1 and a6b4 Integrin signaling	0.0597207015610098	-2.81807655887496	31	18	0.0189473684210526	950	2227	2885,840,4486,207,6464,5295,5376,3688,10971,2064,6198,7534,2065,7531,7533,3265,7532,2810	GRB2,CASP7,MST1R,AKT1,SHC1,PIK3R1,PMP22,ITGB1,YWHAQ,ERBB2,RPS6KB1,YWHAZ,ERBB3,YWHAE,YWHAH,HRAS,YWHAG,SFN
prlsignalingeventspathway	Signaling events mediated by PRL	0.0597902535927162	-2.81691261470818	23	14	0.0147368421052632	950	2227	387,890,1958,389,5879,3688,5876,1026,6093,8073,9564,5594,898,5595	RHOA,CCNA2,EGR1,RHOC,RAC1,ITGB1,RABGGTB,CDKN1A,ROCK1,PTP4A2,BCAR1,MAPK1,CCNE1,MAPK3
erbb1_receptor_proximal_pathway	EGF receptor (ErbB1) signaling pathway	0.0601961592093768	-2.81014672921139	25	15	0.0157894736842105	950	2227	2885,2934,5335,6654,8976,5777,5295,5781,6774,5594,2773,2549,5921,5595,2770	GRB2,GSN,PLCG1,SOS1,WASL,PTPN6,PIK3R1,PTPN11,STAT3,MAPK1,GNAI3,GAB1,RASA1,MAPK3,GNAI1
ar_tf_pathway	Regulation of Androgen receptor activity	0.0680934178318555	-2.68687472494947	50	27	0.0284210526315789	950	2227	23411,2033,5599,6595,1958,8805,2908,5966,5451,10524,1050,10399,1387,4193,6599,2624,5608,51564,3065,2932,10481,3320,6605,29843,6416,10498,83637	SIRT1,EP300,MAPK8,SMARCA2,EGR1,TRIM24,NR3C1,REL,POU2F1,KAT5,CEBPA,GNB2L1,CREBBP,MDM2,SMARCC1,GATA2,MAP2K6,HDAC7,HDAC1,GSK3B,HOXB13,HSP90AA1,SMARCE1,SENP1,MAP2K4,CARM1,ZMIZ2
caspase_pathway	Caspase cascade in apoptosis	0.0680934178318555	-2.68687472494947	50	27	0.0284210526315789	950	2227	836,330,55367,1676,839,7186,842,56616,837,329,1073,4000,4926,2934,840,84823,3984,8567,581,7020,835,317,841,3875,4214,6709,7150	CASP3,BIRC3,PIDD1,DFFA,CASP6,TRAF2,CASP9,DIABLO,CASP4,BIRC2,CFL2,LMNA,NUMA1,GSN,CASP7,LMNB2,LIMK1,MADD,BAX,TFAP2A,CASP2,APAF1,CASP8,KRT18,MAP3K1,SPTAN1,TOP1
s1p_s1p3_pathway	S1P3 pathway	0.0864722087274895	-2.44793220305524	28	16	0.0168421052631579	950	2227	2768,7852,387,207,2781,5879,3717,3685,7422,5594,10672,2773,2771,2767,5595,2770	GNA12,CXCR4,RHOA,AKT1,GNAZ,RAC1,JAK2,ITGAV,VEGFA,MAPK1,GNA13,GNAI3,GNAI2,GNA11,MAPK3,GNAI1
pdgfrbpathway	PDGFR-beta signaling pathway	0.107283549549414	-2.23227995377928	54	28	0.0294736842105263	950	2227	2241,207,6654,4690,5295,5879,7410,4035,8877,6777,7525,9564,4067,5921,2885,25,5335,2534,6464,3091,2886,5781,1785,52,6776,6774,3265,2549	FER,AKT1,SOS1,NCK1,PIK3R1,RAC1,VAV2,LRP1,SPHK1,STAT5B,YES1,BCAR1,LYN,RASA1,GRB2,ABL1,PLCG1,FYN,SHC1,HIF1A,GRB7,PTPN11,DNM2,ACP1,STAT5A,STAT3,HRAS,GAB1
il2_1pathway	IL2-mediated signaling events	0.110717822362375	-2.20077045527608	52	27	0.0284210526315789	950	2227	5599,387,6654,5894,5295,8835,5604,6777,5605,5921,5595,9021,2885,5581,8660,1154,2534,22806,8651,6464,5601,5781,2185,6776,6774,5594,5528	MAPK8,RHOA,SOS1,RAF1,PIK3R1,SOCS2,MAP2K1,STAT5B,MAP2K2,RASA1,MAPK3,SOCS3,GRB2,PRKCE,IRS2,CISH,FYN,IKZF3,SOCS1,SHC1,MAPK9,PTPN11,PTK2B,STAT5A,STAT3,MAPK1,PPP2R5D
wnt_beta_catenin_pathway	Regulation of Wnt-mediated beta catenin signaling and target gene transcription	0.111963986476005	-2.18957800871649	78	39	0.0410526315789474	950	2227	2033,23043,3398,6597,8454,814,324,7531,56998,26959,1499,57680,6925,3491,4286,9968,6591,389058,7091,8913,57167,10971,25776,1857,6934,7532,22943,5308,7514,9314,3065,7534,6907,10856,7533,3619,1487,3066,2810	EP300,TNIK,ID2,SMARCA4,CUL1,CAMK4,APC,YWHAE,CTNNBIP1,HBP1,CTNNB1,CHD8,TCF4,CYR61,MITF,MED12,SNAI2,SP5,TLE4,CACNA1G,SALL4,YWHAQ,CBY1,DVL3,TCF7L2,YWHAG,DKK1,PITX2,XPO1,KLF4,HDAC1,YWHAZ,TBL1X,RUVBL2,YWHAH,INCENP,CTBP1,HDAC2,SFN
ps1pathway	Presenilin action in Notch and Wnt signaling	0.121764488298301	-2.1056665237027	46	24	0.0252631578947368	950	2227	23291,79412,51107,102,51701,324,1452,83464,5595,22943,1387,5467,1499,10023,4040,3065,2932,3516,10454,5594,1487,23385,5528,8321	FBXW11,KREMEN2,APH1A,ADAM10,NLK,APC,CSNK1A1,APH1B,MAPK3,DKK1,CREBBP,PPARD,CTNNB1,FRAT1,LRP6,HDAC1,GSK3B,RBPJ,TAB1,MAPK1,CTBP1,NCSTN,PPP2R5D,FZD1
atf2_pathway	ATF-2 transcription factor network	0.132719075546403	-2.01952059856723	55	28	0.0294736842105263	950	2227	2033,5599,3280,4763,8452,5451,10524,467,672,865,1847,5595,9021,3727,890,1647,3569,3726,5601,5268,9555,10856,10891,5594,1386,1649,1466,1843	EP300,MAPK8,HES1,NF1,CUL3,POU2F1,KAT5,ATF3,BRCA1,CBFB,DUSP5,MAPK3,SOCS3,JUND,CCNA2,GADD45A,IL6,JUNB,MAPK9,SERPINB5,H2AFY,RUVBL2,PPARGC1A,MAPK1,ATF2,DDIT3,CSRP2,DUSP1
ecadherin_stabilization_pathway	Stabilization and expansion of the E-cadherin adherens junction	0.134034606170739	-2.0096572573678	40	21	0.0221052631578947	950	2227	387,4690,51474,1495,55740,360,87,3801,6810,1729,7791,7408,1499,1969,60412,1500,6093,382,4646,7414,4026	RHOA,NCK1,LIMA1,CTNNA1,ENAH,AQP3,ACTN1,KIFC3,STX4,DIAPH1,ZYX,VASP,CTNNB1,EPHA2,EXOC4,CTNND1,ROCK1,ARF6,MYO6,VCL,LPP
myc_represspathway	Validated targets of C-MYC transcriptional repression	0.145766302893727	-1.92575060481834	62	31	0.0326315789473684	950	2227	1030,2033,7709,7249,6908,84233,8841,3398,2064,57447,2495,1050,10608,1026,672,2309,22943,7474,1647,5524,4802,3688,1027,3065,2672,4089,4801,1649,1052,6667,223	CDKN2B,EP300,ZBTB17,TSC2,TBP,TMEM126A,HDAC3,ID2,ERBB2,NDRG2,FTH1,CEBPA,MXD4,CDKN1A,BRCA1,FOXO3,DKK1,WNT5A,GADD45A,PPP2R4,NFYC,ITGB1,CDKN1B,HDAC1,GFI1,SMAD4,NFYB,DDIT3,CEBPD,SP1,ALDH9A1
smad2_3nuclearpathway	Regulation of nuclear SMAD2/3 signaling	0.167740324100516	-1.78533818526775	76	37	0.0389473684210526	950	2227	1030,51588,2033,6929,1026,25942,3693,2309,1387,1745,1386,6667,8819,7709,23309,7050,79753,2648,4303,3915,207,5931,2908,467,865,10401,4088,4087,7030,7027,51586,3065,9611,10284,1487,4089,3066	CDKN2B,PIAS4,EP300,TCF3,CDKN1A,SIN3A,ITGB5,FOXO3,CREBBP,DLX1,ATF2,SP1,SAP30,ZBTB17,SIN3B,TGIF1,SNIP1,KAT2A,FOXO4,LAMC1,AKT1,RBBP7,NR3C1,ATF3,CBFB,PIAS3,SMAD3,SMAD2,TFE3,TFDP1,MED15,HDAC1,NCOR1,SAP18,CTBP1,SMAD4,HDAC2
nephrin_neph1_pathway	Nephrin/Neph1 signaling in the kidney podocyte	0.168186020836928	-1.78268464526024	26	14	0.0147368421052632	950	2227	2885,5599,5335,2534,207,23607,4690,8976,5295,5879,5601,7082,409,6416	GRB2,MAPK8,PLCG1,FYN,AKT1,CD2AP,NCK1,WASL,PIK3R1,RAC1,MAPK9,TJP1,ARRB2,MAP2K4
rhoa_pathway	RhoA signaling pathway	0.168558616670406	-1.78047171626878	41	21	0.0221052631578947	950	2227	5599,387,4659,7430,8394,1729,5606,5586,3491,5608,3984,5590,6548,1027,6722,6093,7414,1386,9475,6416,3985	MAPK8,RHOA,PPP1R12A,EZR,PIP5K1A,DIAPH1,MAP2K3,PKN2,CYR61,MAP2K6,LIMK1,PRKCZ,SLC9A1,CDKN1B,SRF,ROCK1,VCL,ATF2,ROCK2,MAP2K4,LIMK2
pi3kcipathway	Class I PI3K signaling events	0.168558616670406	-1.78047171626878	41	21	0.0221052631578947	950	2227	5170,9267,387,3636,64411,6654,5295,9265,5879,7525,375,4067,2309,5335,5906,2534,381,6446,3320,382,59339	PDPK1,CYTH1,RHOA,INPPL1,ARAP3,SOS1,PIK3R1,CYTH3,RAC1,YES1,ARF1,LYN,FOXO3,PLCG1,RAP1A,FYN,ARF5,SGK1,HSP90AA1,ARF6,PLEKHA2
myc_pathway	C-MYC pathway	0.179441376165668	-1.71790671957496	22	12	0.0126315789473684	950	2227	8464,7709,26959,6881,2648,5062,6502,10524,2932,6883,10856,9913	SUPT3H,ZBTB17,HBP1,TAF10,KAT2A,PAK2,SKP2,KAT5,GSK3B,TAF12,RUVBL2,SUPT7L
glypican_2pathway	Glypican 2 network	0.181863037596497	-1.70450141588481	2	2	0.00210526315789474	950	2227	4192,221914	MDK,GPC2
p38_mk2pathway	p38 signaling mediated by MAPKAP kinases	0.185279136040258	-1.68589174760353	20	11	0.0115789473684211	950	2227	7249,7867,5894,6929,6722,10971,7534,7531,7533,2810,7532	TSC2,MAPKAPK3,RAF1,TCF3,SRF,YWHAQ,YWHAZ,YWHAE,YWHAH,SFN,YWHAG
angiopoietinreceptor_pathway	Angiopoietin receptor Tie2-mediated signaling	0.185835774399161	-1.68289192862201	48	24	0.0252631578947368	950	2227	5599,207,4690,5295,5879,3678,6777,1026,2113,5921,5595,2885,2534,6464,1398,2886,3688,5781,6776,6198,1998,5970,5594,2242	MAPK8,AKT1,NCK1,PIK3R1,RAC1,ITGA5,STAT5B,CDKN1A,ETS1,RASA1,MAPK3,GRB2,FYN,SHC1,CRK,GRB7,ITGB1,PTPN11,STAT5A,RPS6KB1,ELF2,RELA,MAPK1,FES
il1pathway	IL1-mediated signaling events	0.187656720761709	-1.67314093863234	35	18	0.0189473684210526	950	2227	4215,5599,387522,5295,7335,1147,23085,8878,23118,5608,51135,3551,5584,5590,5970,10454,7334,100302736	MAP3K3,MAPK8,TMEM189-UBE2V1,PIK3R1,UBE2V1,CHUK,ERC1,SQSTM1,TAB2,MAP2K6,IRAK4,IKBKB,PRKCI,PRKCZ,RELA,TAB1,UBE2N,TMED7-TICAM2
hivnefpathway	HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.187656720761709	-1.67314093863234	35	18	0.0189473684210526	950	2227	5599,836,5609,330,1676,839,7186,842,1147,840,7185,1616,835,317,841,4217,9020,5970	MAPK8,CASP3,MAP2K7,BIRC3,DFFA,CASP6,TRAF2,CASP9,CHUK,CASP7,TRAF1,DAXX,CASP2,APAF1,CASP8,MAP3K5,MAP3K14,RELA
p38alphabetadownstreampathway	Signaling mediated by p38-alpha and p38-beta	0.187656720761709	-1.67314093863234	35	18	0.0189473684210526	950	2227	3856,7867,8550,5868,4205,9252,466,7391,5743,26959,1978,4286,6548,8986,10891,1977,1386,1649	KRT8,MAPKAPK3,MAPKAPK5,RAB5A,MEF2A,RPS6KA5,ATF1,USF1,PTGS2,HBP1,EIF4EBP1,MITF,SLC9A1,RPS6KA4,PPARGC1A,EIF4E,ATF2,DDIT3
avb3_integrin_pathway	Integrins in angiogenesis	0.192653000202605	-1.64686463469822	46	23	0.0242105263157895	950	2227	387,207,5295,5879,4240,5297,50848,7422,9564,6382,5595,5298,961,5781,2185,1027,6198,3685,3320,6093,841,7414,5594	RHOA,AKT1,PIK3R1,RAC1,MFGE8,PI4KA,F11R,VEGFA,BCAR1,SDC1,MAPK3,PI4KB,CD47,PTPN11,PTK2B,CDKN1B,RPS6KB1,ITGAV,HSP90AA1,ROCK1,CASP8,VCL,MAPK1
ephbfwdpathway	EPHB forward signaling	0.194663727559444	-1.63648168308954	33	17	0.0178947368421053	950	2227	6237,4690,5295,5879,5604,1947,5921,5595,2885,8976,2886,6093,2050,5594,3265,6453,2049	RRAS,NCK1,PIK3R1,RAC1,MAP2K1,EFNB1,RASA1,MAPK3,GRB2,WASL,GRB7,ROCK1,EPHB4,MAPK1,HRAS,ITSN1,EPHB3
syndecan_2_pathway	Syndecan-2-mediated signaling events	0.194663727559444	-1.63648168308954	33	17	0.0178947368421053	950	2227	5599,836,387,8573,4763,3678,7430,10399,5566,5921,5595,2035,3673,3688,581,5594,3265	MAPK8,CASP3,RHOA,CASK,NF1,ITGA5,EZR,GNB2L1,PRKACA,RASA1,MAPK3,EPB41,ITGA2,ITGB1,BAX,MAPK1,HRAS
ceramide_pathway	Ceramide signaling pathway	0.199804659701022	-1.61041509121269	44	22	0.0231578947368421	950	2227	5599,207,330,7186,5894,5604,9131,427,5074,8575,5605,5595,5610,8567,581,5590,841,5594,5970,56848,6416,4214	MAPK8,AKT1,BIRC3,TRAF2,RAF1,MAP2K1,AIFM1,ASAH1,PAWR,PRKRA,MAP2K2,MAPK3,EIF2AK2,MADD,BAX,PRKCZ,CASP8,MAPK1,RELA,SPHK2,MAP2K4,MAP3K1
wnt_canonical_pathway	Canonical Wnt signaling pathway	0.202036839317528	-1.59930522534979	31	16	0.0168421052631579	950	2227	23291,1499,1454,139285,8452,8454,2932,4040,5520,1857,324,857,7855,1452,1856,55361	FBXW11,CTNNB1,CSNK1E,AMER1,CUL3,CUL1,GSK3B,LRP6,PPP2R2A,DVL3,APC,CAV1,FZD5,CSNK1A1,DVL2,PI4K2A
mapktrkpathway	Trk receptor signaling mediated by the MAPK pathway	0.209809594776443	-1.56155485109882	29	15	0.0157894736842105	950	2227	673,5607,1958,5608,5894,5604,6722,6016,5598,30844,9252,5594,5606,23623,5595	BRAF,MAP2K5,EGR1,MAP2K6,RAF1,MAP2K1,SRF,RIT1,MAPK7,EHD4,RPS6KA5,MAPK1,MAP2K3,RUSC1,MAPK3
reg_gr_pathway	Glucocorticoid receptor regulatory network	0.211135011353037	-1.5552574858995	82	39	0.0410526315789474	950	2227	2033,5599,1958,6908,5087,6597,6777,1026,5566,1387,4193,51111,5601,581,6446,3320,5106,5970,5567,207,2908,3164,632,5451,6601,5595,6599,3569,7251,3065,2932,6776,5536,7533,5594,2810,3066,3659,6602	EP300,MAPK8,EGR1,TBP,PBX1,SMARCA4,STAT5B,CDKN1A,PRKACA,CREBBP,MDM2,KMT5B,MAPK9,BAX,SGK1,HSP90AA1,PCK2,RELA,PRKACB,AKT1,NR3C1,NR4A1,BGLAP,POU2F1,SMARCC2,MAPK3,SMARCC1,IL6,TSG101,HDAC1,GSK3B,STAT5A,PPP5C,YWHAH,MAPK1,SFN,HDAC2,IRF1,SMARCD1
ifngpathway	IFN-gamma pathway	0.21522171473295	-1.53608655089217	40	20	0.0210526315789474	950	2227	51588,2033,207,2475,5295,5604,808,5595,1387,1399,817,8651,4296,5781,3717,3459,5594,6774,4214,3659	PIAS4,EP300,AKT1,MTOR,PIK3R1,MAP2K1,CALM3,MAPK3,CREBBP,CRKL,CAMK2D,SOCS1,MAP3K11,PTPN11,JAK2,IFNGR1,MAPK1,STAT3,MAP3K1,IRF1
nectin_pathway	Nectin adhesion pathway	0.226716843301962	-1.48405342646961	25	13	0.0136842105263158	950	2227	9076,5817,1398,1499,25945,8826,1495,5797,5295,5879,7410,50848,3685	CLDN1,PVR,CRK,CTNNB1,PVRL3,IQGAP1,CTNNA1,PTPRM,PIK3R1,RAC1,VAV2,F11R,ITGAV
trail_pathway	TRAIL signaling pathway	0.226716843301962	-1.48405342646961	25	13	0.0136842105263158	950	2227	5599,7818,7186,5295,3551,8743,1147,841,8793,5594,6416,5595,4214	MAPK8,DAP3,TRAF2,PIK3R1,IKBKB,TNFSF10,CHUK,CASP8,TNFRSF10D,MAPK1,MAP2K4,MAPK3,MAP3K1
retinoic_acid_pathway	Retinoic acid receptors-mediated signaling	0.226716843301962	-1.48405342646961	25	13	0.0136842105263158	950	2227	5599,4331,8202,5914,207,8841,6256,3065,5594,5566,8204,983,5595	MAPK8,MNAT1,NCOA3,RARA,AKT1,HDAC3,RXRA,HDAC1,MAPK1,PRKACA,NRIP1,CDK1,MAPK3
fcer1pathway	Fc-epsilon receptor I signaling in mast cells	0.228322543249376	-1.47699598634676	58	28	0.0294736842105263	950	2227	5599,2241,5609,207,6654,5894,5295,5604,8877,1147,4067,5605,5921,5595,2885,5335,8611,2534,6464,5062,3551,5781,5594,5970,3265,6416,1843,4214	MAPK8,FER,MAP2K7,AKT1,SOS1,RAF1,PIK3R1,MAP2K1,SPHK1,CHUK,LYN,MAP2K2,RASA1,MAPK3,GRB2,PLCG1,PLPP1,FYN,SHC1,PAK2,IKBKB,PTPN11,MAPK1,RELA,HRAS,MAP2K4,DUSP1,MAP3K1
bmppathway	BMP receptor signaling	0.232347915007819	-1.45951939698907	36	18	0.0189473684210526	950	2227	659,4090,64750,8021,654,25805,23645,9241,2932,5494,5499,4086,4091,57154,5594,10106,4089,58190	BMPR2,SMAD5,SMURF2,NUP214,BMP6,BAMBI,PPP1R15A,NOG,GSK3B,PPM1A,PPP1CA,SMAD1,SMAD6,SMURF1,MAPK1,CTDSP2,SMAD4,CTDSP1
cxcr4_pathway	CXCR4-mediated signaling events	0.233002500545377	-1.45670609351961	76	36	0.0378947368421053	950	2227	2475,79109,2782,6777,2870,4067,5899,5781,3717,253260,6774,64223,5170,207,83737,5777,5295,9525,5908,7525,10399,5747,9564,6773,7852,2534,1398,3984,3673,5590,3688,2185,6776,27183,10672,409	MTOR,MAPKAP1,GNB1,STAT5B,GRK6,LYN,RALB,PTPN11,JAK2,RICTOR,STAT3,MLST8,PDPK1,AKT1,ITCH,PTPN6,PIK3R1,VPS4B,RAP1B,YES1,GNB2L1,PTK2,BCAR1,STAT2,CXCR4,FYN,CRK,LIMK1,ITGA2,PRKCZ,ITGB1,PTK2B,STAT5A,VPS4A,GNA13,ARRB2
trkrpathway	Neurotrophic factor-mediated Trk receptor signaling	0.236608597620807	-1.44134798988671	56	27	0.0284210526315789	950	2227	391,387,6654,10287,5295,5879,5604,6016,5921,5595,2885,25,1399,5335,1398,8878,6464,9093,5781,5590,5584,55179,30844,6774,5594,2549,10818	RHOG,RHOA,SOS1,RGS19,PIK3R1,RAC1,MAP2K1,RIT1,RASA1,MAPK3,GRB2,ABL1,CRKL,PLCG1,CRK,SQSTM1,SHC1,DNAJA3,PTPN11,PRKCZ,PRKCI,FAIM,EHD4,STAT3,MAPK1,GAB1,FRS2
lysophospholipid_pathway	LPA receptor mediated events	0.2394323964328	-1.42948417156838	65	31	0.0326315789473684	950	2227	836,387,9170,7205,207,5295,5879,2782,5747,9564,2773,4067,2767,23566,2770,5581,2768,5335,1398,2781,3569,9138,115,2932,2185,2771,5970,10672,3265,2549,4137	CASP3,RHOA,LPAR2,TRIP6,AKT1,PIK3R1,RAC1,GNB1,PTK2,BCAR1,GNAI3,LYN,GNA11,LPAR3,GNAI1,PRKCE,GNA12,PLCG1,CRK,GNAZ,IL6,ARHGEF1,ADCY9,GSK3B,PTK2B,GNAI2,RELA,GNA13,HRAS,GAB1,MAPT
cxcr3pathway	CXCR3-mediated signaling events	0.241655672229093	-1.42024140805491	34	17	0.0178947368421053	950	2227	5170,207,2475,5894,5295,5604,79109,2782,2773,5605,5606,5595,5608,253260,2771,5594,64223	PDPK1,AKT1,MTOR,RAF1,PIK3R1,MAP2K1,MAPKAP1,GNB1,GNAI3,MAP2K2,MAP2K3,MAPK3,MAP2K6,RICTOR,GNAI2,MAPK1,MLST8
avb3_opn_pathway	Osteopontin-mediated events	0.251529133836709	-1.38019645584631	32	16	0.0168421052631579	950	2227	5599,2934,387,5295,5879,2185,1147,3685,9020,8394,9564,5970,5594,9475,5595,4214	MAPK8,GSN,RHOA,PIK3R1,RAC1,PTK2B,CHUK,ITGAV,MAP3K14,PIP5K1A,BCAR1,RELA,MAPK1,ROCK2,MAPK3,MAP3K1
p75ntrpathway	p75(NTR)-mediated signaling	0.256673361169581	-1.35995097066377	61	29	0.0305263157894737	950	2227	5599,836,387,6868,6272,207,839,51107,5295,5879,842,5045,56616,57142,1147,7531,83464,56160,8878,6464,27018,5601,3551,396,5590,5584,317,10018,23385	MAPK8,CASP3,RHOA,ADAM17,SORT1,AKT1,CASP6,APH1A,PIK3R1,RAC1,CASP9,FURIN,DIABLO,RTN4,CHUK,YWHAE,APH1B,NDNL2,SQSTM1,SHC1,NGFRAP1,MAPK9,IKBKB,ARHGDIA,PRKCZ,PRKCI,APAF1,BCL2L11,NCSTN
cdc42_reg_pathway	Regulation of CDC42 activity	0.262032052712407	-1.33928844410682	30	15	0.0157894736842105	950	2227	8412,55114,5335,23268,115557,4830,10928,7410,396,392,324,50618,23229,6453,2245	BCAR3,ARHGAP17,PLCG1,DNMBP,ARHGEF25,NME1,RALBP1,VAV2,ARHGDIA,ARHGAP1,APC,ITSN2,ARHGEF9,ITSN1,FGD1
epha2_fwdpathway	EPHA2 forward signaling	0.267628670463005	-1.31815481721817	17	9	0.00947368421052632	950	2227	2885,387,3636,1969,5295,5879,7410,52,9564	GRB2,RHOA,INPPL1,EPHA2,PIK3R1,RAC1,VAV2,ACP1,BCAR1
aurora_b_pathway	Aurora B signaling	0.270029553327721	-1.30922386920438	39	19	0.02	950	2227	387,1058,10112,6867,5037,54888,8452,4691,11004,10592,9212,5501,5921,6790,699,3619,151648,5528,10051	RHOA,CENPA,KIF20A,TACC1,PEBP1,NSUN2,CUL3,NCL,KIF2C,SMC2,AURKB,PPP1CC,RASA1,AURKA,BUB1,INCENP,SGOL1,PPP2R5D,SMC4
il2_pi3kpathway	IL2 signaling events mediated by PI3K	0.281005910348188	-1.26937957660201	37	18	0.0189473684210526	950	2227	207,6654,2475,7357,5295,5879,808,598,2309,8661,2885,6464,6194,5590,5781,6198,3320,5970	AKT1,SOS1,MTOR,UGCG,PIK3R1,RAC1,CALM3,BCL2L1,FOXO3,EIF3A,GRB2,SHC1,RPS6,PRKCZ,PTPN11,RPS6KB1,HSP90AA1,RELA
faspathway	FAS (CD95) signaling pathway	0.2926546819489	-1.22876192491431	35	17	0.0178947368421053	950	2227	5170,5599,836,5609,207,330,5295,7430,1147,329,5608,1213,5601,3551,5981,841,4214	PDPK1,MAPK8,CASP3,MAP2K7,AKT1,BIRC3,PIK3R1,EZR,CHUK,BIRC2,MAP2K6,CLTC,MAPK9,IKBKB,RFC1,CASP8,MAP3K1
alk1pathway	ALK1 signaling events	0.29816687843687	-1.21010195446068	24	12	0.0126315789473684	950	2227	3397,90,659,92,4090,5499,857,4086,409,5594,4089,5595	ID1,ACVR1,BMPR2,ACVR2A,SMAD5,PPP1CA,CAV1,SMAD1,ARRB2,MAPK1,SMAD4,MAPK3
s1p_s1p2_pathway	S1P2 pathway	0.29816687843687	-1.21010195446068	24	12	0.0126315789473684	950	2227	5599,2768,387,2781,5879,5594,2773,2771,10672,2767,5595,2770	MAPK8,GNA12,RHOA,GNAZ,RAC1,MAPK1,GNAI3,GNAI2,GNA13,GNA11,MAPK3,GNAI1
ncadherinpathway	N-cadherin signaling events	0.305049516217163	-1.18728116729879	33	16	0.0168421052631579	950	2227	5599,2241,387,1495,5295,5879,808,2260,3799,5335,2934,1499,221955,1500,2017,6093	MAPK8,FER,RHOA,CTNNA1,PIK3R1,RAC1,CALM3,FGFR1,KIF5B,PLCG1,GSN,CTNNB1,DAGLB,CTNND1,CTTN,ROCK1
alk2pathway	ALK2 signaling events	0.307815557558628	-1.17825451447967	11	6	0.00631578947368421	950	2227	4090,90,659,4086,4089,268	SMAD5,ACVR1,BMPR2,SMAD1,SMAD4,AMH
pdgfrapathway	PDGFR-alpha signaling pathway	0.312141313790109	-1.1642992648995	22	11	0.0115789473684211	950	2227	2885,1399,5335,6464,1398,6654,5295,90525,6722,3685,857	GRB2,CRKL,PLCG1,SHC1,CRK,SOS1,PIK3R1,SHF,SRF,ITGAV,CAV1
reelinpathway	Reelin signaling pathway	0.332443101766622	-1.10128655603575	29	14	0.0147368421052632	950	2227	1399,5599,2534,4043,5906,5609,207,5048,5295,3688,4296,9181,2932,4137	CRKL,MAPK8,FYN,LRPAP1,RAP1A,MAP2K7,AKT1,PAFAH1B1,PIK3R1,ITGB1,MAP3K11,ARHGEF2,GSK3B,MAPT
ar_nongenomic_pathway	Nongenotropic Androgen signaling	0.344045638423896	-1.0669809605717	18	9	0.00947368421052632	950	2227	207,5894,5295,5604,2782,5594,3265,5605,5595	AKT1,RAF1,PIK3R1,MAP2K1,GNB1,MAPK1,HRAS,MAP2K2,MAPK3
p38alphabetapathway	Regulation of p38-alpha and p38-beta	0.347672438583651	-1.05649451091676	27	13	0.0136842105263158	950	2227	4215,2534,5608,80824,83605,5879,5062,7525,10454,4067,6416,5606,1843	MAP3K3,FYN,MAP2K6,DUSP16,CCM2,RAC1,PAK2,YES1,TAB1,LYN,MAP2K4,MAP2K3,DUSP1
il6_7pathway	IL6-mediated signaling events	0.357160663359458	-1.02956956101751	43	20	0.0210526315789474	950	2227	207,6654,5295,5879,7297,9021,10401,2885,3569,5608,8543,3572,4286,3726,5781,3717,6774,6416,1052,3659	AKT1,SOS1,PIK3R1,RAC1,TYK2,SOCS3,PIAS3,GRB2,IL6,MAP2K6,LMO4,IL6ST,MITF,JUNB,PTPN11,JAK2,STAT3,MAP2K4,CEBPD,IRF1
hif2pathway	HIF-2-alpha transcription factor network	0.361399599760995	-1.01777100829282	34	16	0.0168421052631579	950	2227	23411,2033,328,6923,2034,9429,3646,4891,6921,7422,2113,1387,112398,112399,10370,6667	SIRT1,EP300,APEX1,TCEB2,EPAS1,ABCG2,EIF3E,SLC11A2,TCEB1,VEGFA,ETS1,CREBBP,EGLN2,EGLN3,CITED2,SP1
plk3_pathway	PLK3 signaling events	0.364190107794403	-1.01007927352263	5	3	0.00315789473684211	950	2227	1263,995,898	PLK3,CDC25C,CCNE1
hes_heypathway	Notch-mediated HES/HEY network	0.379046614790755	-0.970096087292016	48	22	0.0231578947368421	950	2227	2033,3280,3397,2626,632,6929,23028,23493,1387,817,2627,3091,23013,3065,1027,3717,3516,9611,7528,9794,6774,1487	EP300,HES1,ID1,GATA4,BGLAP,TCF3,KDM1A,HEY2,CREBBP,CAMK2D,GATA6,HIF1A,SPEN,HDAC1,CDKN1B,JAK2,RBPJ,NCOR1,YY1,MAML1,STAT3,CTBP1
lymphangiogenesis_pathway	VEGFR3 signaling in lymphatic endothelium	0.381981802505363	-0.962382308930775	23	11	0.0115789473684211	950	2227	2885,207,1398,6654,5295,3673,3688,3678,5594,6416,5595	GRB2,AKT1,CRK,SOS1,PIK3R1,ITGA2,ITGB1,ITGA5,MAPK1,MAP2K4,MAPK3
aurora_kinase_pathway	Signaling by Aurora kinases	0.390617283895381	-0.940027011914394	3	2	0.00210526315789474	950	2227	6790,9212	AURKA,AURKB
aurora_c_pathway	Aurora C signaling	0.390617283895381	-0.940027011914394	3	2	0.00210526315789474	950	2227	9212,3619	AURKB,INCENP
pi3kcibpathway	Class IB PI3K non-lipid kinase events	0.390617283895381	-0.940027011914394	3	2	0.00210526315789474	950	2227	5594,5604	MAPK1,MAP2K1
cd40_pathway	CD40/CD40L signaling	0.394052769689524	-0.931270445430315	30	14	0.0147368421052632	950	2227	5599,7128,7185,207,330,7186,5601,6776,9020,958,5970,329,6416,4214	MAPK8,TNFAIP3,TRAF1,AKT1,BIRC3,TRAF2,MAPK9,STAT5A,MAP3K14,CD40,RELA,BIRC2,MAP2K4,MAP3K1
s1p_meta_pathway	Sphingosine 1-phosphate (S1P) pathway	0.401502016467198	-0.912542723273692	21	10	0.0105263157894737	950	2227	2768,53637,2781,8877,2773,56848,10672,2771,2767,2770	GNA12,S1PR5,GNAZ,SPHK1,GNAI3,SPHK2,GNA13,GNAI2,GNA11,GNAI1
wnt_signaling_pathway	Wnt signaling network	0.412179928818547	-0.886295304533858	28	13	0.0136842105263158	950	2227	79412,8322,8325,8326,6259,4040,7855,2535,8324,22943,10159,7474,8321	KREMEN2,FZD4,FZD8,FZD9,RYK,LRP6,FZD5,FZD2,FZD7,DKK1,ATP6AP2,WNT5A,FZD1
syndecan_1_pathway	Syndecan-1-mediated signaling events	0.446908393594406	-0.805401641401238	17	8	0.00842105263157895	950	2227	682,5479,8573,10855,5594,5566,6382,5595	BSG,PPIB,CASK,HPSE,MAPK1,PRKACA,SDC1,MAPK3
et_egfrpathway	EGFR-dependent Endothelin signaling events	0.468114419797396	-0.759042526199932	8	4	0.00421052631578947	950	2227	2885,6654,2475,3265	GRB2,SOS1,MTOR,HRAS
glypican_3pathway	Glypican 3 network	0.468114419797396	-0.759042526199932	8	4	0.00421052631578947	950	2227	5727,5599,5601,5045	PTCH1,MAPK8,MAPK9,FURIN
hif1apathway	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.473809857882311	-0.746949181474926	15	7	0.00736842105263158	950	2227	6921,10399,3320,6923,3091,9978,8453	TCEB1,GNB2L1,HSP90AA1,TCEB2,HIF1A,RBX1,CUL2
anthraxpathway	Cellular roles of Anthrax toxin	0.475969268697571	-0.742401988394629	22	10	0.0105263157894737	950	2227	5609,5608,5604,808,3606,5594,5605,6416,5606,5595	MAP2K7,MAP2K6,MAP2K1,CALM3,IL18,MAPK1,MAP2K2,MAP2K4,MAP2K3,MAPK3
tcptp_pathway	Signaling events mediated by TCPTP	0.477431407832141	-0.739334777898866	36	16	0.0168421052631579	950	2227	6654,5295,6777,7422,1387,2885,3643,5610,6778,3688,3838,6776,3998,6774,2549,3837	SOS1,PIK3R1,STAT5B,VEGFA,CREBBP,GRB2,INSR,EIF2AK2,STAT6,ITGB1,KPNA2,STAT5A,LMAN1,STAT3,GAB1,KPNB1
ptp1bpathway	Signaling events mediated by PTP1B	0.477616921272945	-0.738946287730392	50	22	0.0231578947368421	950	2227	2241,387,207,5295,6777,7525,857,9564,4067,7297,9021,2885,3643,2534,1398,6464,6776,4904,3717,6774,10253,823	FER,RHOA,AKT1,PIK3R1,STAT5B,YES1,CAV1,BCAR1,LYN,TYK2,SOCS3,GRB2,INSR,FYN,CRK,SHC1,STAT5A,YBX1,JAK2,STAT3,SPRY2,CAPN1
erbb1_internalization_pathway	Internalization of ErbB1	0.497179035516689	-0.698805085325686	34	15	0.0157894736842105	950	2227	2885,7323,6654,10617,5894,5295,7322,9101,7251,29924,5868,7321,10253,30011,6453	GRB2,UBE2D3,SOS1,STAMBP,RAF1,PIK3R1,UBE2D2,USP8,TSG101,EPN1,RAB5A,UBE2D1,SPRY2,SH3KBP1,ITSN1
tcrjnkpathway	JNK signaling in the CD4+ TCR pathway	0.504546393442077	-0.68409548416557	13	6	0.00631578947368421	950	2227	1399,5599,28988,1398,6416,4214	CRKL,MAPK8,DBNL,CRK,MAP2K4,MAP3K1
erbb_network_pathway	ErbB receptor signaling network	0.504546393442077	-0.68409548416557	13	6	0.00631578947368421	950	2227	2064,685,2065,3320,7039,2069	ERBB2,BTC,ERBB3,HSP90AA1,TGFA,EREG
nfkappabalternativepathway	Alternative NF-kappaB pathway	0.510730118494864	-0.671913972141187	6	3	0.00315789473684211	950	2227	1147,9020,4791	CHUK,MAP3K14,NFKB2
ephrinb_ephbpathway	EphrinB-EPHB pathway	0.510730118494864	-0.671913972141187	6	3	0.00315789473684211	950	2227	2050,1947,2049	EPHB4,EFNB1,EPHB3
alphasynuclein_pathway	Alpha-synuclein signaling	0.518120154101123	-0.657548105896513	32	14	0.0147368421052632	950	2227	10273,5071,2534,1861,7332,2185,5337,7525,4067,5594,5528,11315,5595,6622	STUB1,PARK2,FYN,TOR1A,UBE2L3,PTK2B,PLD1,YES1,LYN,MAPK1,PPP2R5D,PARK7,MAPK3,SNCA
arf_3pathway	Arf1 pathway	0.529198597734916	-0.636391496527697	18	8	0.00842105263157895	950	2227	1173,50807,160,5879,23647,375,8394,8729	AP2M1,ASAP1,AP2A1,RAC1,ARFIP2,ARF1,PIP5K1A,GBF1
foxm1pathway	FOXM1 transcription factor network	0.53461365585819	-0.626210931536615	37	16	0.0168421052631579	950	2227	1387,2033,1058,2931,7039,2119,6502,4751,5604,1163,9212,891,9133,983,2619,6667	CREBBP,EP300,CENPA,GSK3A,TGFA,ETV5,SKP2,NEK2,MAP2K1,CKS1B,AURKB,CCNB1,CCNB2,CDK1,GAS1,SP1
tcrraspathway	Ras signaling in the CD4+ TCR pathway	0.540377251812799	-0.615487768873161	11	5	0.00526315789473684	950	2227	673,5594,5894,5595,5604	BRAF,MAPK1,RAF1,MAPK3,MAP2K1
nfkappabcanonicalpathway	Canonical NF-kappaB pathway	0.548267319618614	-0.600992301451491	23	10	0.0105263157894737	950	2227	7323,7514,7128,3551,10892,1147,5901,5970,329,23085	UBE2D3,XPO1,TNFAIP3,IKBKB,MALT1,CHUK,RAN,RELA,BIRC2,ERC1
fgf_pathway	FGF signaling pathway	0.562224186049268	-0.575854601069939	47	20	0.0210526315789474	950	2227	5170,207,6654,632,5295,6777,10298,2260,5595,2885,5335,6464,5781,2185,1500,2017,5594,2549,10818,10253	PDPK1,AKT1,SOS1,BGLAP,PIK3R1,STAT5B,PAK4,FGFR1,MAPK3,GRB2,PLCG1,SHC1,PTPN11,PTK2B,CTNND1,CTTN,MAPK1,GAB1,FRS2,SPRY2
plk_pathway	Polo-like kinase signaling events in the cell cycle	0.570273591193609	-0.561639048759086	4	2	0.00210526315789474	950	2227	1263,10733	PLK3,PLK4
er_nongenomic_pathway	Plasma membrane estrogen receptor signaling	0.589342851101994	-0.528747174523125	26	11	0.0115789473684211	950	2227	2885,6801,387,207,6654,5295,2782,2100,9564,10672,9475	GRB2,STRN,RHOA,AKT1,SOS1,PIK3R1,GNB1,ESR2,BCAR1,GNA13,ROCK2
nfkappabatypicalpathway	Atypical NF-kappaB pathway	0.595482159748677	-0.518383849076054	14	6	0.00631578947368421	950	2227	602,5970,409,5966,5295,3551	BCL3,RELA,ARRB2,REL,PIK3R1,IKBKB
circadianpathway	Circadian rhythm pathway	0.595482159748677	-0.518383849076054	14	6	0.00631578947368421	950	2227	1111,11091,9575,5187,1454,406	CHEK1,WDR5,CLOCK,PER1,CSNK1E,ARNTL
lis1pathway	Lissencephaly gene (LIS1) in neuronal migration and development	0.600975353771206	-0.509201353987966	31	13	0.0136842105263158	950	2227	25,6249,387,4043,81565,5048,8826,5879,808,5049,7531,5528,10726	ABL1,CLIP1,RHOA,LRPAP1,NDEL1,PAFAH1B1,IQGAP1,RAC1,CALM3,PAFAH1B2,YWHAE,PPP2R5D,NUDC
a4b1_paxdep_pathway	Paxillin-dependent events mediated by a4b1	0.606432656569846	-0.500161592921543	19	8	0.00842105263157895	950	2227	1399,1398,5295,5879,3688,382,5566,9564	CRKL,CRK,PIK3R1,RAC1,ITGB1,ARF6,PRKACA,BCAR1
notch_pathway	Notch signaling pathway	0.628559968573119	-0.464323840112792	58	24	0.0252631578947368	950	2227	2033,54567,51107,102,83737,5045,6502,8454,1026,83464,8766,23028,57534,182,23013,3065,3516,9611,9794,7528,26292,23385,1487,8650	EP300,DLL4,APH1A,ADAM10,ITCH,FURIN,SKP2,CUL1,CDKN1A,APH1B,RAB11A,KDM1A,MIB1,JAG1,SPEN,HDAC1,RBPJ,NCOR1,MAML1,YY1,MYCBP,NCSTN,CTBP1,NUMB
rapid_gr_pathway	Rapid glucocorticoid signaling	0.636816548236046	-0.451273658238029	7	3	0.00315789473684211	950	2227	2782,5599,5601	GNB1,MAPK8,MAPK9
a4b1_paxindep_pathway	Paxillin-independent events mediated by a4b1 and a4b7	0.645381810966471	-0.437913182335829	22	9	0.00947368421052632	950	2227	1399,387,1398,5295,5879,3688,3717,382,9564	CRKL,RHOA,CRK,PIK3R1,RAC1,ITGB1,JAK2,ARF6,BCAR1
ephrinbrevpathway	Ephrin B reverse signaling	0.651474650986166	-0.428516791867729	27	11	0.0115789473684211	950	2227	5599,7852,2534,5998,5295,5879,7525,2050,4067,6416,1947	MAPK8,CXCR4,FYN,RGS3,PIK3R1,RAC1,YES1,EPHB4,LYN,MAP2K4,EFNB1
bcr_5pathway	BCR signaling pathway	0.660097580592136	-0.415367605508284	66	27	0.0284210526315789	950	2227	5170,5599,207,6654,5777,5894,5295,5879,7410,5604,10892,808,1147,5532,2113,4067,5921,5595,2885,6464,3551,5533,4793,5594,5970,3265,4214	PDPK1,MAPK8,AKT1,SOS1,PTPN6,RAF1,PIK3R1,RAC1,VAV2,MAP2K1,MALT1,CALM3,CHUK,PPP3CB,ETS1,LYN,RASA1,MAPK3,GRB2,SHC1,IKBKB,PPP3CC,NFKBIB,MAPK1,RELA,HRAS,MAP3K1
ecadherin_1_pathway	E-cadherin signaling events	0.671302656157274	-0.398535191308668	2	1	0.00105263157894737	950	2227	1499	CTNNB1
plk2_4pathway	PLK2 and PLK4 events	0.671302656157274	-0.398535191308668	2	1	0.00105263157894737	950	2227	10733	PLK4
il2_stat5pathway	IL2 signaling events mediated by STAT5	0.682320365121333	-0.382255987853984	30	12	0.0126315789473684	950	2227	2885,890,6464,6654,5295,896,5781,6776,6777,598,1021,6667	GRB2,CCNA2,SHC1,SOS1,PIK3R1,CCND3,PTPN11,STAT5A,STAT5B,BCL2L1,CDK6,SP1
syndecan_4_pathway	Syndecan-4-mediated signaling events	0.733696161767081	-0.309660284614183	31	12	0.0126315789473684	950	2227	4192,7852,387,84309,5879,3688,1785,3678,87,2260,8324,7057	MDK,CXCR4,RHOA,NUDT16L1,RAC1,ITGB1,DNM2,ITGA5,ACTN1,FGFR1,FZD7,THBS1
rhoa_reg_pathway	Regulation of RhoA activity	0.737132534355557	-0.304987573441117	46	18	0.0189473684210526	950	2227	387,50650,64411,115557,10276,9138,7204,7410,396,116985,57522,4983,9181,84033,1027,23365,11214,9828	RHOA,ARHGEF3,ARAP3,ARHGEF25,NET1,ARHGEF1,TRIO,VAV2,ARHGDIA,ARAP1,SRGAP1,OPHN1,ARHGEF2,OBSCN,CDKN1B,ARHGEF12,AKAP13,ARHGEF17
cmyb_pathway	C-MYB transcription factor network	0.739841642100952	-0.301319112845457	78	31	0.0326315789473684	950	2227	2033,3280,6595,3015,330,839,8826,51701,1050,161882,1026,25942,891,2113,10155,4144,1387,10401,5743,8089,2114,5481,8379,1027,4254,5292,9611,1021,8535,1052,6667	EP300,HES1,SMARCA2,H2AFZ,BIRC3,CASP6,IQGAP1,NLK,CEBPA,ZFPM1,CDKN1A,SIN3A,CCNB1,ETS1,TRIM28,MAT2A,CREBBP,PIAS3,PTGS2,YEATS4,ETS2,PPID,MAD1L1,CDKN1B,KITLG,PIM1,NCOR1,CDK6,CBX4,CEBPD,SP1
rxr_vdr_pathway	RXR and RAR heterodimerization with other nuclear receptor	0.785436871585895	-0.241515191688711	14	5	0.00526315789473684	950	2227	84498,6198,5469,3164,6256	FAM120B,RPS6KB1,MED1,NR4A1,RXRA
il4_2pathway	IL4-mediated signaling events	0.792909317581797	-0.232046417503064	60	23	0.0242105263157895	950	2227	207,54625,2475,5777,5295,2971,6777,3597,2113,9021,2885,8660,8651,6464,6778,6776,6198,3717,3159,4603,2242,6667,9655	AKT1,PARP14,MTOR,PTPN6,PIK3R1,GTF3A,STAT5B,IL13RA1,ETS1,SOCS3,GRB2,IRS2,SOCS1,SHC1,STAT6,STAT5A,RPS6KB1,JAK2,HMGA1,MYBL1,FES,SP1,SOCS5
hif1_tfpathway	HIF-1-alpha transcription factor network	0.793697849588846	-0.231052432239051	65	25	0.0263157894736842	950	2227	2033,5236,207,5045,9429,3398,7422,5315,2113,7037,133,1387,4088,7852,5211,2624,3091,51564,226,664,3098,10370,112399,4089,6667	EP300,PGM1,AKT1,FURIN,ABCG2,ID2,VEGFA,PKM,ETS1,TFRC,ADM,CREBBP,SMAD3,CXCR4,PFKL,GATA2,HIF1A,HDAC7,ALDOA,BNIP3,HK1,CITED2,EGLN3,SMAD4,SP1
syndecan_3_pathway	Syndecan-3-mediated signaling events	0.804479527746708	-0.217559760049732	17	6	0.00631578947368421	950	2227	8573,2534,2017,83464,51107,23385	CASK,FYN,CTTN,APH1B,APH1A,NCSTN
cd8tcrpathway	TCR signaling in naive CD8+ T cells	0.809494808417417	-0.211344919205065	48	18	0.0189473684210526	950	2227	5170,207,6654,5777,10892,83593,567,1147,3105,2885,5581,5335,5906,2534,6786,3551,84876,9020	PDPK1,AKT1,SOS1,PTPN6,MALT1,RASSF5,B2M,CHUK,HLA-A,GRB2,PRKCE,PLCG1,RAP1A,FYN,STIM1,IKBKB,ORAI1,MAP3K14
glypicanpathway	Glypican pathway	0.811645342292123	-0.208691804808714	3	1	0.00105263157894737	950	2227	221914	GPC2
alk1_2pathway	ALK1 pathway	0.811645342292123	-0.208691804808714	3	1	0.00105263157894737	950	2227	90	ACVR1
ephrinarevpathway	Ephrin A  reverse signaling	0.811645342292123	-0.208691804808714	3	1	0.00105263157894737	950	2227	2534	FYN
a4b1_a4b7_pathway	a4b1 and a4b7 Integrin signaling	0.811645342292123	-0.208691804808714	3	1	0.00105263157894737	950	2227	3688	ITGB1
botulinumtoxinpathway	Effects of Botulinum toxin	0.815402082129239	-0.204073935093697	9	3	0.00315789473684211	950	2227	6616,25782,6857	SNAP25,RAB3GAP2,SYT1
il27pathway	IL27-mediated signaling events	0.849502474306351	-0.163104425212413	26	9	0.00947368421052632	950	2227	3592,3569,3572,6776,3606,3717,6774,7297,6773	IL12A,IL6,IL6ST,STAT5A,IL18,JAK2,STAT3,TYK2,STAT2
txa2pathway	Thromboxane A2 receptor signaling	0.870343877644106	-0.138866883768928	45	16	0.0168421052631579	950	2227	387,207,5879,2782,7525,5566,4067,8766,5581,2534,10681,9138,5590,6093,2771,409	RHOA,AKT1,RAC1,GNB1,YES1,PRKACA,LYN,RAB11A,PRKCE,FYN,GNB5,ARHGEF1,PRKCZ,ROCK1,GNAI2,ARRB2
endothelinpathway	Endothelins	0.876536936930483	-0.13177643411632	53	19	0.02	950	2227	5599,387,207,5894,5879,5604,9564,5605,5595,5581,2768,1907,1398,115,6548,2185,3717,5594,3265	MAPK8,RHOA,AKT1,RAF1,RAC1,MAP2K1,BCAR1,MAP2K2,MAPK3,PRKCE,GNA12,EDN2,CRK,ADCY9,SLC9A1,PTK2B,JAK2,MAPK1,HRAS
il12_2pathway	IL12-mediated signaling events	0.882999368848936	-0.124430793158799	61	22	0.0231578947368421	950	2227	2475,7879,10912,567,3606,8809,7297,3105,5606,3592,8651,3142,5608,6778,4616,6776,3717,4791,6774,5970,1386,56848	MTOR,RAB7A,GADD45G,B2M,IL18,IL18R1,TYK2,HLA-A,MAP2K3,IL12A,SOCS1,HLX,MAP2K6,STAT6,GADD45B,STAT5A,JAK2,NFKB2,STAT3,RELA,ATF2,SPHK2
hnf3apathway	FOXA1 transcription factor network	0.885093987854856	-0.122061438647192	43	15	0.0157894736842105	950	2227	2033,1387,8202,4824,7494,4774,5451,1027,4782,4731,672,7026,8204,4781,6667	EP300,CREBBP,NCOA3,NKX3-1,XBP1,NFIA,POU2F1,CDKN1B,NFIC,NDUFV3,BRCA1,NR2F2,NRIP1,NFIB,SP1
syndecan_pathway	Proteogylcan syndecan-mediated signaling events	0.892102592666467	-0.114174138815678	4	1	0.00105263157894737	950	2227	6382	SDC1
hedgehog_2pathway	Signaling events mediated by the Hedgehog family	0.895904512514821	-0.109921442540278	22	7	0.00736842105263158	950	2227	5727,4043,207,409,5295,55733,2619	PTCH1,LRPAP1,AKT1,ARRB2,PIK3R1,HHAT,GAS1
il12_stat4pathway	IL12 signaling mediated by STAT4	0.909021523944502	-0.095386506378172	28	9	0.00947368421052632	950	2227	1387,5599,5601,2119,9063,3606,6774,8809,3659	CREBBP,MAPK8,MAPK9,ETV5,PIAS2,IL18,STAT3,IL18R1,IRF1
epha_fwdpathway	EPHA forward signaling	0.915110118844294	-0.088710872484202	31	10	0.0105263157894737	950	2227	1399,5335,387,2534,1398,1969,7410,7525,6093,4067	CRKL,PLCG1,RHOA,FYN,CRK,EPHA2,VAV2,YES1,ROCK1,LYN
arf6_pathway	Arf6 signaling events	0.920842967779564	-0.0824657591319348	34	11	0.0115789473684211	950	2227	23527,1969,4690,23303,9265,9922,51454,154,382,409,2767	ACAP2,EPHA2,NCK1,KIF13B,CYTH3,IQSEC1,GULP1,ADRB2,ARF6,ARRB2,GNA11
lpa4_pathway	LPA4-mediated signaling events	0.93924662796261	-0.0626771846727941	15	4	0.00421052631578947	950	2227	5581,9252,5566,115	PRKCE,RPS6KA5,PRKACA,ADCY9
tcr_pathway	TCR signaling in naive CD4+ T cells	0.948094115890303	-0.0533015032895878	60	20	0.0210526315789474	950	2227	5170,207,6654,4690,5777,10892,83593,28988,1147,2885,5581,5335,5906,2534,6464,6786,3551,5781,84876,9020	PDPK1,AKT1,SOS1,NCK1,PTPN6,MALT1,RASSF5,DBNL,CHUK,GRB2,PRKCE,PLCG1,RAP1A,FYN,SHC1,STIM1,IKBKB,PTPN11,ORAI1,MAP3K14
rac1_reg_pathway	Regulation of RAC1 activity	0.955382624304801	-0.0456433650193732	39	12	0.0126315789473684	950	2227	55114,115557,4830,6654,10928,5879,7204,7410,396,5910,9181,392	ARHGAP17,ARHGEF25,NME1,SOS1,RALBP1,RAC1,TRIO,VAV2,ARHGDIA,RAP1GDS1,ARHGEF2,ARHGAP1
p38gammadeltapathway	Signaling mediated by p38-gamma and p38-delta	0.967850918475422	-0.0326772134057334	10	2	0.00210526315789474	950	2227	5608,5606	MAP2K6,MAP2K3
glypican_1pathway	Glypican 1 network	0.969312841892477	-0.0311678689460638	26	7	0.00736842105263158	950	2227	7525,2534,4087,7422,4067,9353,2260	YES1,FYN,SMAD2,VEGFA,LYN,SLIT2,FGFR1
hnf3bpathway	FOXA2 and FOXA3 transcription factor networks	0.975101241325313	-0.0252139761182732	44	13	0.0136842105263158	950	2227	3157,207,2908,4763,211,1375,1050,3767,2294,1052,7037,6667,7080	HMGCS1,AKT1,NR3C1,NF1,ALAS1,CPT1B,CEBPA,KCNJ11,FOXF1,CEBPD,TFRC,SP1,NKX2-1
cd8tcrdownstreampathway	Downstream signaling in naive CD8+ T cells	0.977558692366991	-0.0226969455829549	50	15	0.0157894736842105	950	2227	5599,5581,673,1958,5894,3726,5601,5604,808,567,3454,5594,5605,3105,5595	MAPK8,PRKCE,BRAF,EGR1,RAF1,JUNB,MAPK9,MAP2K1,CALM3,B2M,IFNAR1,MAPK1,MAP2K2,HLA-A,MAPK3
fra_pathway	Validated transcriptional targets of AP1 family members Fra1 and Fra2	0.984132297079199	-0.0159949427160215	34	9	0.00947368421052632	950	2227	2033,890,55787,3569,632,3726,9988,3727,6667	EP300,CCNA2,TXLNG,IL6,BGLAP,JUNB,DMTF1,JUND,SP1
tcrcalciumpathway	Calcium signaling in the CD4+ TCR pathway	0.984273590376454	-0.015851381575102	28	7	0.00736842105263158	950	2227	5451,808,5743,23523,5566,3726,11261	POU2F1,CALM3,PTGS2,CABIN1,PRKACA,JUNB,CHP1
il23pathway	IL23-mediated signaling events	0.984356213443502	-0.0157674419060627	37	10	0.0105263157894737	950	2227	3569,5295,6776,3606,3717,5970,6774,8809,7297,9021	IL6,PIK3R1,STAT5A,IL18,JAK2,RELA,STAT3,IL18R1,TYK2,SOCS3
ephrina_ephapathway	EphrinA-EPHA pathway	0.98842047499985	-0.0116470897849418	8	1	0.00105263157894737	950	2227	1969	EPHA2
amb2_neutrophils_pathway	amb2 Integrin signaling	0.991955087529016	-0.00807744739052386	48	13	0.0136842105263158	950	2227	3146,387,2534,4486,207,1490,3491,3569,5590,4035,7525,6093,4067	HMGB1,RHOA,FYN,MST1R,AKT1,CTGF,CYR61,IL6,PRKCZ,LRP1,YES1,ROCK1,LYN
nfat_tfpathway	Calcineurin-regulated NFAT-dependent transcription in lymphocytes	0.99884056153884	-0.0011601111299284	48	11	0.0115789473684211	950	2227	5743,836,6520,79589,1958,5468,83737,3726,808,5451,1960	PTGS2,CASP3,SLC3A2,RNF128,EGR1,PPARG,ITCH,JUNB,CALM3,POU2F1,EGR3
rhodopsin_pathway	Visual signal transduction: Rods	0.999952919579714	-4.70815286037732e-05	23	2	0.00210526315789474	950	2227	2782,10681	GNB1,GNB5
cone_pathway	Visual signal transduction: Cones	0.999997442761665	-2.55724160453026e-06	23	1	0.00105263157894737	950	2227	10681	GNB5
hnf3pathway	FOXA transcription factor networks	0.999999999996489	-3.51110807095267e-12	3	0	0	950	2227