TermID	Term	Enrichment	logP	Genes in Term	Target Genes in Term	Fraction of Targets in Term	Total Target Genes	Total Genes	Entrez Gene IDs	Gene Symbols
R-HSA-74160	Gene Expression	2.43508634525637e-58	-132.659953177685	1330	775	0.246344564526383	3146	8202	7249,23019,134353,196513,57505,8350,5252,6147,7587,9997,1387,29894,6429,7004,8665,6227,9972,6882,30834,5094,64223,23293,84527,7311,8731,4774,55634,3185,10421,8239,10168,5432,6827,10781,4087,11051,5719,6233,115509,3065,56006,9282,7029,6188,55181,6749,7621,124411,833,5689,84626,255967,171568,1660,10775,10081,5715,5073,51067,6137,9343,51493,9968,92285,50628,10419,58500,79902,26986,6228,79587,9295,2976,7760,57459,171392,170959,340385,199704,79101,10526,84914,9219,51639,55253,1974,5702,55814,6204,100289635,6604,6746,51742,6430,8487,6875,7458,5685,79027,10181,6726,92935,2957,6158,10127,90338,221785,57472,9440,388567,6727,158431,387032,3735,348995,3303,10556,7695,6996,285971,147923,10286,23381,7586,57122,10213,730087,7769,51121,84967,90075,25920,284370,6881,2617,5441,65251,8669,6169,10921,80032,5433,6232,116228,6873,7514,29927,90874,11157,25937,6176,8243,197320,2521,6637,23112,136051,6187,353274,6908,9422,51058,9491,9883,10542,121504,2146,5708,22938,81857,83860,79833,84924,1349,7314,374655,7965,4670,5694,79691,83744,7738,5931,113802,6895,5710,7316,23450,5917,7733,6136,1968,22835,51002,10128,7767,51808,7533,7745,9337,6256,3646,8358,83443,6745,80108,6427,84844,22869,5701,284459,6168,5901,1983,4603,1977,7551,23471,8331,8463,55176,10291,7068,54913,4234,80205,121536,118460,11176,5468,5571,4736,8575,27244,9969,6009,2744,1981,1107,1874,9128,54464,6619,80746,7596,58528,163050,348180,6884,5693,51003,5713,8649,10949,1327,55571,6125,9349,57103,112950,23658,339559,126070,1656,54482,8932,7625,9443,9794,5686,54811,10621,23309,8968,122402,388561,51504,6829,2100,80222,81856,7025,5704,25873,6257,9167,389541,5434,163049,2810,79744,353355,65109,6181,51276,6235,8270,55659,5520,7576,64121,6156,85456,5093,6135,6218,5687,25888,9441,284443,1108,7539,6207,23411,57711,6629,11224,5436,6923,207,10971,9631,79084,7697,10907,8021,286075,3921,8667,4088,5903,1994,90592,84449,5709,23536,80324,7566,10284,3020,8338,6146,8662,4089,55762,6122,6202,162966,9150,51362,7978,26147,10250,90649,79175,5716,7407,2971,54815,6234,1337,3726,2963,81605,653604,3320,84172,2959,10302,147837,5692,7936,2908,2626,54802,5465,115196,7581,8357,6175,11128,6189,9416,4848,5467,80778,3012,58492,6210,339487,7761,6418,65988,1965,3190,3516,6124,6883,90353,51503,9410,84838,23511,3015,5565,5356,1964,79973,5720,7531,25942,404672,53981,16,51728,8365,125919,57521,143686,6217,220992,6134,1490,8366,5688,6194,54778,5494,93587,81929,80110,6731,388536,124454,6133,7771,148213,208,54888,29115,8661,1207,6165,6208,10785,9045,10325,6747,2972,6341,3066,6617,6627,1329,57343,23395,5440,102157402,5562,7702,6748,255403,7633,154007,4849,129401,10643,23016,54807,4850,29128,162972,1936,5915,23404,6154,84775,1479,5393,219988,148156,8175,4781,5691,221830,155054,51422,50484,6730,51586,9329,8892,353088,9611,2101,8467,29959,57541,8354,9534,55599,146434,23512,282890,10978,92595,79074,29883,285267,348327,220988,79818,23054,8364,56915,117608,103,7321,8819,1350,5725,3183,1353,7884,10025,7728,11260,10155,7532,27335,55954,905,121274,1650,2074,54487,2539,7307,80139,1967,10046,56242,3014,6173,283742,126068,4306,5711,3842,6224,10594,201514,51333,10667,25804,1915,7755,2962,22826,6139,3184,23438,6143,26019,54512,2068,5469,7050,2648,9328,9589,6132,6129,5430,8334,23405,7027,65243,126231,8570,1478,6152,6878,284306,6839,115708,7559,51204,2071,285268,6636,7692,51241,79042,9924,80153,10992,5696,9775,57721,6917,55703,27257,3192,6222,163081,285521,10498,8352,84124,23020,7561,6230,147929,51690,10413,199692,25929,7343,163071,55663,80317,27297,5690,90317,10795,6741,5705,5700,6231,22823,7323,6209,51010,6872,55621,6138,7592,9887,3187,7270,23378,23165,54541,9668,8178,127253,1938,84246,6205,6729,4904,55657,24148,25799,64425,5438,7594,91975,57677,6921,8368,100131827,6130,4331,54901,23636,7534,6907,5916,116461,192669,7571,7766,126382,79088,57504,51123,2475,5683,339327,1875,6193,11022,6635,54925,54517,29079,3181,79595,2193,54700,3376,10849,23198,3191,10794,27300,65110,55534,148103,2975,6877,5914,6734,5695,23644,5451,6142,7556,51585,11100,6618,53615,6203,8666,8294,10236,5706,1978,8351,55157,9861,23049,1030,51497,8367,8480,10482,7673,10644,7376,6728,8360,7988,6164,57209,56259,9014,6155,8125,5717,344787,8345,146540,55778,6667,7296,1024,3164,7003,6171,388569,84265,64750,4221,9669,55422,6626,3304,5595,9125,148254,51592,7175,5976,57335,1351,57819,22916,4782,6206,6428,9533,6633	TSC2,CNOT1,LSM11,DCP1B,AARS2,HIST1H3A,PHF1,RPL23A,ZNF37A,SCO2,CREBBP,CPSF1,SRSF4,TEAD4,EIF3F,RPS21,NUP153,TAF11,ZNRD1,PCBP2,MLST8,SMG6,ZNF559,UBA52,RNMT,NFIA,KRBOX4,HNRNPF,CD2BP2,USP9X,ZNF197,POLR2C,SUPT4H1,ZNF266,SMAD2,NUDT21,PSMD13,RPS27A,ZNF689,HDAC1,SMG9,MED14,TFDP2,RPS3,SMG8,SSRP1,ZNF70,ZNF720,CARS,PSMB1,KRBA1,PAN3,POLR3H,DHX9,POP4,PDCD7,PSMD9,PARN,YARS2,RPL13,EFTUD2,RTCB,MED12,ZNF585B,GEMIN4,PRMT5,ZNF250,NUP85,PABPC1,RPS23,CARS2,SRSF11,GTF3C2,ZNF213,GATAD2B,ZNF675,ZNF431,ZNF517,ZNF585A,TAF1D,IPO8,ZNF587,MTA2,SF3B6,TYW1,EIF4A2,PSMC3,BDP1,RPS10,ZNF605,SMARCD3,SSR2,ARID4B,SRSF5,GEMIN2,TAF4B,EIF4H,PSMA4,ZNF655,RBM5,SRP9,MARS2,GTF2A1,RPL28,ZNF263,ZNF160,ZSCAN25,CNOT6,MED17,ZNF749,SRP14,ZNF782,ZKSCAN4,KARS,NUP43,HSPA1A,RPP30,ZNF136,TDG,ZNF775,ZNF420,BCAS2,SMG5,ZKSCAN1,NUP107,PSMD14,ZNF726,ZNF226,RPL26L1,LSM10,ZNF30,NELFB,ZNF615,TAF10,GARS,POLR2L,ZNF649,EIF3J,RPL38,RNPS1,ZNF556,POLR2D,RPS27,COX20,TAF2,XPO1,SEC61A1,ZNF697,LSM6,WWTR1,RPLP1,SMC1A,ZNF778,FUS,SNRPG,TNRC6B,ZNF786,RPS2,ZNF445,TBP,ZNF264,ZNF691,PSMF1,POM121,LAMTOR5,HIST4H4,EZH2,PSMD2,SNW1,MED25,TAF3,GEMIN6,ZNF566,COX7B,UBB,ZNF710,AIMP2,HNRNPM,PSMB6,QTRTD1,ZNF484,ZNF184,RBBP7,HENMT1,TARBP2,PSMD4,UBC,SF3B3,RARS,ZNF180,RPL12,EIF2S3,ZFP30,TPRKB,LRPPRC,ZNF224,PHAX,YWHAH,ZKSCAN8,CNOT8,RXRA,EIF3E,HIST1H3B,SF3B5,SSR1,ZFP2,SRSF2,PHF5A,ZNF510,PSMC2,HKR1,RPL37A,RAN,EIF5,MYBL1,EIF4E,ZNF3,TRAM1,HIST1H2AJ,TEAD2,SEC61A2,SF3A1,THRB,RPP25,METTL1,CHD9,AEBP2,EXOSC6,BAZ2A,PPARG,PRKAG1,RPL10A,PRKRA,SESN1,MED13,RHEB,GLS,EIF4G1,CHD3,E2F4,PRPF4,XRN1,SNAPC3,TSEN2,ZNF45,RRAGD,ZNF564,CTU2,TAF13,PSMB5,MED31,PSMD7,LAMTOR3,HNRNPA0,COX4I1,CNOT11,RPL5,RPL23,TIGAR,MED8,LSM5,ZFP69,ZNF440,DDX6,TRMT13,MBD2,ZNF74,MED7,MAML1,PSMA5,ZNF562,POLR3F,SIN3B,HIST1H3F,TDRD9,ZNF761,TRMT112,SUPT5H,ESR2,TARS2,ZNF611,NR2F1,PSMC4,RPL36,RXRB,COX7A2L,LAMTOR4,POLR2E,ZNF791,SFN,ZNF419,ZNF233,UPF3B,RPLP2,ZNF571,RPS29,LAGE3,ZNF416,PPP2R2A,ZNF28,RRAGC,RPL30,TNKS1BP1,PCBP1,RPL11,RPS17,PSMA6,ZNF473,MED26,ZNF493,CHD4,ZFP37,RPS13,SIRT1,ZNF529,SNRPB2,RPL35,POLR2G,TCEB2,AKT1,YWHAQ,NUP155,WDR77,ZNF138,TXNL4A,NUP214,ZNF707,RPSA,EIF3H,SMAD3,RANBP2,ELAVL1,ZNF700,ZNF333,PSMD3,ADAT1,PUS1,ZNF18,SAP18,H3F3A,HIST2H2AC,RPL22,EIF3B,SMAD4,ZNF701,RPL3,RPS8,ZNF600,CTDP1,CDC40,MTERF1,PHF19,SRRM1,ZNF486,ZNF343,PSMD10,VARS,GTF3A,GATAD2A,RPS28,COX6A1,JUNB,GTF2F2,URM1,HIST2H3D,HSP90AA1,POLR1B,GTF2B,SNAPC5,ZNF563,PSMB4,NELFE,NR3C1,GATA4,TRIT1,PPARA,ZNF554,ZNF33A,HIST1H3H,RPLP0,POLR3A,RPS3A,DDX23,CNOT2,PPARD,ZNF34,HIST1H2AE,ZNF77,RPS15A,ZBTB8OS,ZNF214,SET,ZNF747,EIF2S1,HNRNPK,RBPJ,RPL4,TAF12,CTU1,CWC15,SNRNP40,ZNF496,NUP188,H2AFZ,PRKAB2,PLRG1,EIF1AX,ZNF442,PSME1,YWHAE,SIN3A,GTF2H5,CPSF2,AARS,POLR3K,HIST1H4H,ZNF543,RPTOR,SESN3,RPS16,ZNF485,RPL10,CTGF,HIST1H4B,PSMA7,RPS6,RNF111,PPM1A,TRMT10A,SEH1L,ZNF614,SRP72,ZNF790,EARS2,RPL9,ZNF112,ZNF681,AKT2,NSUN2,SAP30BP,EIF3A,CLNS1A,RPL35A,RPS14,WDR4,RPL14,RRAGB,SSR3,BRF1,SCO1,HDAC2,SNAPC1,SNRPA1,COX5B,ZNF304,LARS2,POLR2K,AK6,PRKAA1,ZNF143,SSR4,ZNF718,ZNF79,SNRNP48,CNOT3,NUP35,IGF2BP3,EXOSC7,ZNF586,CNOT4,UHRF1,ZNF550,EEF1D,RARB,EXOSC2,RPL26,ZNF607,CSTF3,EXOSC9,PATL1,ZNF558,SF3A2,NFIB,PSMB3,TWISTNB,ZNF425,PRKAG2,RRM2B,SRP68,MED15,GTF3C4,EIF2B2,ZNF429,NCOR1,ESRRA,SMARCA5,NRBP1,ZNF398,HIST1H3I,ZNF254,RNPC3,ZNF597,SUZ12,ZNF311,CLP1,ZNF764,C2orf49,CNOT7,ZNF619,ZNF530,HNRNPA3,ZNF552,NCOA6,HIST1H4C,EXOSC5,ZNF354B,ADAR,UBE2D1,SAP30,COX7C,PTBP1,HNRNPC,COX11,SLBP,MED16,ZNF175,XPOT,TRIM28,YWHAG,EIF3K,ZMAT5,CCNT2,ZNF641,DDOST,ERCC6,DGCR8,G6PD,U2AF1,ZNF703,EIF2B1,MAMLD1,ZNF253,H2AFX,RPL36A,FAM98B,ZNF441,NR3C2,PSMD5,TNPO1,RPS20,PRPF8,ZNF584,ZNF771,FARS2,LSM4,EEF1A1,ZNF205,GTF2F1,DNAJC8,RPL17,HNRNPD,HARS2,RPL19,UPF2,EXOSC4,ERCC2,MED1,TGIF1,KAT2A,GTF3C5,WTAP,RPL8,RPL7,POLR2A,HIST1H2AC,DICER1,TFDP1,ZFP69B,ZNF573,KHSRP,CSTF2,RPL24,TAF6,ZNF547,SUV39H1,TRMT61A,ZNF12,TACO1,ERCC3,ZNF621,SNRPF,ZNF133,COX16,TSEN34,PAN2,EDC3,SF3B2,PSMB8,EIF4A3,METTL14,TCEA1,POLR3B,LSM1,HNRNPU,RPS18,ZNF567,COX18,CARM1,HIST1H3C,ZNF394,SNRNP200,ZNF14,RPS25,ZNF565,LSM7,YAP1,ZNF627,GEMIN5,UBTF,ZNF114,ZNF446,ZKSCAN3,CRCP,PSMB2,ZNF616,ZNF268,SSB,PSMC5,PSMC1,RPS26,MTF2,UBE2D3,RPS15,EXOSC3,TAF1,TRMT1,RPL15,ZNF41,SMG7,HNRNPH1,TTF1,RRP8,NUP205,DDIT4,ZNF432,ELL,TYW3,EEF2,MED10,RPS11,SRP54,YBX1,ZNF692,PRPF6,ZNF324,POLR1E,POLR2I,ZNF43,ZNF300,ZFP14,TCEB1,HIST1H4L,ZNF717,RPL7A,MNAT1,CDKAL1,NUP62,YWHAZ,TBL1X,RARG,TSEN15,AGO3,ZNF23,ZNF223,NR2C2AP,ZNF426,MTA3,ZNF706,MTOR,PSMA2,ZNF546,E2F5,RPS5,TDRKH,SNRPE,ZSCAN32,PUS7,MED4,HNRNPA2B1,SAP130,FARSA,RRN3,IARS,CD3EAP,PSME4,HNRNPL,ZNF460,ZNF544,UPF3A,MAML3,ZNF599,GTF3C1,TAF5,RARA,SRPR,PSMB7,EDC4,POU2F1,RPL18A,ZNF10,PCF11,HNRNPUL1,SNAPC2,MBD3,RPS9,EIF3G,HIST1H4I,HNRNPR,PSMC6,EIF4EBP1,HIST1H3D,DARS2,PSMD6,SMG1,CDKN2B,NELFCD,HIST1H4E,RAE1,NXF1,ZNF222,IGF2BP2,NR1H2,SRP19,HIST1H4D,ZNF212,RPL34,ZNF248,CTNNBL1,TAF1B,RPL27,ANP32A,PSMD11,ZNF860,HIST1H2BH,ZNF785,ZNF839,SP1,TXNRD1,CDK8,NR4A1,TEAD1,RPL41,ZNF324B,POLR3GL,SMURF2,MEN1,EIF5B,ZNF331,SNRPA,HSPA1B,MAPK3,RQCD1,ZNF555,TRIM33,TPR,UPF1,ZNF286A,COX8A,LSM2,NCBP2,NFIC,RPS12,SRSF3,POLR1C,SNRPD2
R-HSA-1640170	Cell Cycle	4.8746240315562e-27	-60.5857545310955	572	342	0.108709472345836	3146	8202	5883,11116,3015,23511,5862,8454,10524,8350,5720,7531,891,580,898,5519,79003,8365,1031,7465,9183,8366,5688,26277,8379,4361,9972,1021,81929,7311,5810,1454,9212,10592,11083,79959,5982,84296,5557,4926,5719,25936,6233,91754,7298,3065,5527,7029,1870,55957,51433,5689,63967,51773,5715,55142,129401,4000,9126,2010,81876,4751,79902,993,10274,10112,5558,5422,5702,4605,7468,22994,5685,5691,1859,5000,5888,23592,23063,8481,6790,8467,54820,3619,91750,1029,8354,2033,80321,10383,5048,9232,348995,5566,54386,25909,890,65057,8364,57122,10213,1027,84126,51434,80254,4438,7321,1032,23141,5984,5983,23224,1871,6232,9088,8697,5861,7532,79682,3796,8318,5529,5889,7514,79980,4085,8243,3014,5500,51720,23383,79184,7334,5711,203068,4172,84142,51588,6396,54069,641,9491,55320,9883,7341,9793,121504,9702,5708,55920,55835,896,85378,29781,7314,10051,10726,5694,11130,328,5931,140609,55755,29882,9025,5710,220134,7316,6249,8334,81930,23310,5426,5427,5001,7027,57082,7533,9700,55135,23291,2029,201254,8358,11004,1026,286826,64682,4218,5111,5696,51343,51529,5701,84131,10393,8331,7112,8352,1058,23133,256126,6241,990,64105,672,983,10133,7158,1874,5690,5705,7840,5700,5528,11258,4175,5693,55355,4659,5713,3978,1111,7084,23165,51053,80184,1763,9735,5686,8968,4999,8368,7324,5704,84930,23244,4331,5108,23421,996,4957,10806,113130,4660,23636,7534,10856,9133,2810,23594,5425,10142,5116,57405,5683,8655,1875,5520,157570,64900,9656,5424,132660,4193,5687,10733,23198,81565,348235,991,114791,10735,5695,10971,11144,121441,9631,1736,8021,995,8294,5903,7336,5706,5709,8351,84515,7444,5981,23122,9861,8338,3020,151648,5594,255919,1030,1781,55388,8367,8480,10926,54821,5716,984,5501,8360,26271,7153,151246,8317,387893,653604,1163,5717,55166,699,3320,79019,8345,23595,9837,25777,5692,29893,6502,5905,10714,8357,79866,5595,401541,221496,64326,7175,3012,6418,1719,147841,55125,11065,8556,7013	RAD9A,FGFR1OP,H2AFZ,NUP188,RAB2A,CUL1,KAT5,HIST1H3A,PSME1,YWHAE,CCNB1,BARD1,CCNE1,PPP2R1B,MIS12,HIST1H4H,CDKN2C,WEE1,ZW10,HIST1H4B,PSMA7,TINF2,MAD1L1,MRE11A,NUP153,CDK6,SEH1L,UBA52,RAD1,CSNK1E,AURKB,SMC2,DIDO1,CEP76,RFC2,GINS4,PRIM1,NUMA1,PSMD13,NSL1,RPS27A,NEK9,TYMS,HDAC1,PPP2R5C,TFDP2,E2F2,LIN37,ANAPC5,PSMB1,CLSPN,RSF1,PSMD9,HAUS2,NUP35,LMNA,SMC3,EMD,RAB1B,NEK2,NUP85,CDC25A,STAG1,KIF20A,PRIM2,POLA1,PSMC3,MYBL2,WHSC1,CEP131,PSMA4,PSMB3,DYRK1A,ORC4,RAD51,LEMD3,WAPL,OFD1,AURKA,SMARCA5,NDE1,INCENP,LIN52,CDKN2A,HIST1H3I,EP300,CEP70,TUBB4B,PAFAH1B1,PTTG1,NUP43,PRKACA,TERF2IP,AHCTF1,CCNA2,ACD,HIST1H4C,NUP107,PSMD14,CDKN1B,ATRIP,ANAPC7,CEP63,MSH4,UBE2D1,CDKN2D,ANKLE2,RFC4,RFC3,SYNE2,E2F3,RPS27,PKMYT1,CDC23,RAB1A,YWHAG,CENPU,KIF2A,CDC45,PPP2R5E,RAD51C,XPO1,DSN1,MAD2L1,SMC1A,H2AFX,PPP1CB,UIMC1,MAU2,BRCC3,UBE2N,PSMD5,TUBB,MCM3,FAM175A,PIAS4,SEC13,MIS18A,BLM,PSMF1,MIS18BP1,POM121,SUMO1,CKAP5,HIST4H4,CEP57,PSMD2,RCC2,CENPJ,CCND3,TUBGCP6,NCAPH2,UBB,SMC4,NUDC,PSMB6,ZWINT,APEX1,RBBP7,NEK7,CDK5RAP2,ANAPC2,RNF8,PSMD4,SKA1,UBC,CLIP1,HIST1H2AC,KIF18A,NCAPD3,POLE,POLE2,ORC5,TFDP1,CASC5,YWHAH,ESPL1,WRAP53,FBXW11,ENSA,STRA13,HIST1H3B,KIF2C,CDKN1A,LIN9,ANAPC1,RAB8A,PCNA,PSMB8,FZR1,ANAPC11,PSMC2,CEP78,ANAPC10,HIST1H2AJ,TMPO,HIST1H3C,CENPA,PHF8,SYCE2,RRM2,CDC6,CENPK,BRCA1,CDK1,OPTN,TP53BP1,E2F4,PSMB2,PSMC5,ALMS1,PSMC1,PPP2R5D,DCTN3,MCM6,PSMB5,HJURP,PPP1R12A,PSMD7,LIG1,CHEK1,TK2,NUP205,GMNN,CEP290,DNA2,KNTC1,PSMA5,HIST1H3F,ORC2,HIST1H4L,UBE2E1,PSMC4,MASTL,PDS5A,MNAT1,PCM1,ITGB3BP,CDC27,ODF2,SDCCAG8,CDCA5,PPP1R12B,NUP62,YWHAZ,RUVBL2,CCNB2,SFN,ORC6,POLD2,AKAP9,PCNT,SPC25,PSMA2,DYNLL1,E2F5,PPP2R2A,ESCO2,LPIN3,MDC1,POLD1,LIN54,MDM2,PSMA6,PLK4,PSME4,NDEL1,SKA2,CDC20,TUBGCP5,STAG2,PSMB7,YWHAQ,DMC1,NEDD1,NUP155,DKC1,NUP214,CDC25C,HIST1H4I,RANBP2,UBE2V2,PSMC6,PSMD3,HIST1H3D,MCM8,VRK2,RFC1,CLASP2,PSMD6,HIST2H2AC,H3F3A,SGOL1,MAPK1,CNEP1R1,CDKN2B,DYNC1I2,MCM10,HIST1H4E,RAE1,DBF4,ERCC6L,PSMD10,CDK11B,PPP1CC,HIST1H4D,FBXO5,TOP2A,SGOL2,CDC7,KMT5A,HIST2H3D,CKS1B,PSMD11,CENPQ,BUB1,HSP90AA1,CENPM,HIST1H2BH,ORC3,GINS1,SUN2,PSMB4,PSMC3IP,SKP2,RANGAP1,POLD3,HIST1H3H,BORA,MAPK3,CENPP,LEMD2,RFWD2,TPR,HIST1H2AE,SET,DHFR,SPC24,CEP192,UBE2C,CDC14A,TERF1
R-HSA-69278	Cell Cycle, Mitotic	2.05880195159878e-25	-56.8425030881249	477	292	0.0928162746344564	3146	8202	11116,3015,23511,5862,8454,8350,5720,7531,891,898,5519,79003,8365,1031,7465,9183,8366,5688,8379,9972,1021,81929,7311,1454,9212,10592,79959,5982,84296,5557,4926,5719,25936,6233,91754,7298,3065,5527,7029,1870,55957,51433,5689,5715,55142,129401,4000,9126,2010,81876,4751,79902,993,10274,10112,5558,5422,5702,4605,22994,5685,5691,1859,5000,23592,23063,8481,6790,54820,3619,91750,1029,8354,2033,80321,10383,5048,9232,348995,5566,25909,890,8364,57122,10213,1027,51434,80254,7321,1032,23141,5984,5983,1871,6232,9088,8697,5861,7532,79682,3796,8318,5529,7514,79980,4085,8243,3014,5500,23383,5711,203068,4172,6396,9491,9883,9793,121504,9702,5708,55920,55835,85378,896,29781,7314,10051,10726,5694,11130,328,140609,55755,29882,5710,220134,7316,6249,81930,23310,8334,5426,5427,5001,7027,57082,9700,23291,2029,8358,11004,1026,286826,64682,4218,5696,5111,51343,51529,5701,84131,10393,8331,7112,8352,1058,23133,6241,990,64105,983,10133,1874,5690,5705,7840,5700,5528,11258,5693,4175,4659,5713,3978,7084,23165,51053,80184,1763,9735,5686,8968,4999,8368,7324,84930,23244,5704,4331,5108,23421,996,4957,10806,113130,4660,23636,9133,5425,23594,10142,5116,57405,5683,8655,1875,157570,5520,64900,5424,132660,5687,10733,23198,81565,348235,991,114791,10735,5695,121441,9631,8021,995,8294,5903,5706,5709,8351,84515,7444,5981,23122,9861,8338,3020,151648,5594,255919,1030,1781,55388,8367,8480,10926,54821,5716,984,5501,8360,26271,7153,151246,8317,387893,653604,1163,699,55166,5717,79019,8345,3320,23595,9837,5692,6502,5905,10714,79866,8357,5595,401541,221496,7175,3012,6418,1719,147841,55125,11065,8556	FGFR1OP,H2AFZ,NUP188,RAB2A,CUL1,HIST1H3A,PSME1,YWHAE,CCNB1,CCNE1,PPP2R1B,MIS12,HIST1H4H,CDKN2C,WEE1,ZW10,HIST1H4B,PSMA7,MAD1L1,NUP153,CDK6,SEH1L,UBA52,CSNK1E,AURKB,SMC2,CEP76,RFC2,GINS4,PRIM1,NUMA1,PSMD13,NSL1,RPS27A,NEK9,TYMS,HDAC1,PPP2R5C,TFDP2,E2F2,LIN37,ANAPC5,PSMB1,PSMD9,HAUS2,NUP35,LMNA,SMC3,EMD,RAB1B,NEK2,NUP85,CDC25A,STAG1,KIF20A,PRIM2,POLA1,PSMC3,MYBL2,CEP131,PSMA4,PSMB3,DYRK1A,ORC4,LEMD3,WAPL,OFD1,AURKA,NDE1,INCENP,LIN52,CDKN2A,HIST1H3I,EP300,CEP70,TUBB4B,PAFAH1B1,PTTG1,NUP43,PRKACA,AHCTF1,CCNA2,HIST1H4C,NUP107,PSMD14,CDKN1B,ANAPC7,CEP63,UBE2D1,CDKN2D,ANKLE2,RFC4,RFC3,E2F3,RPS27,PKMYT1,CDC23,RAB1A,YWHAG,CENPU,KIF2A,CDC45,PPP2R5E,XPO1,DSN1,MAD2L1,SMC1A,H2AFX,PPP1CB,MAU2,PSMD5,TUBB,MCM3,SEC13,PSMF1,POM121,CKAP5,HIST4H4,CEP57,PSMD2,RCC2,CENPJ,TUBGCP6,CCND3,NCAPH2,UBB,SMC4,NUDC,PSMB6,ZWINT,APEX1,NEK7,CDK5RAP2,ANAPC2,PSMD4,SKA1,UBC,CLIP1,KIF18A,NCAPD3,HIST1H2AC,POLE,POLE2,ORC5,TFDP1,CASC5,ESPL1,FBXW11,ENSA,HIST1H3B,KIF2C,CDKN1A,LIN9,ANAPC1,RAB8A,PSMB8,PCNA,FZR1,ANAPC11,PSMC2,CEP78,ANAPC10,HIST1H2AJ,TMPO,HIST1H3C,CENPA,PHF8,RRM2,CDC6,CENPK,CDK1,OPTN,E2F4,PSMB2,PSMC5,ALMS1,PSMC1,PPP2R5D,DCTN3,PSMB5,MCM6,PPP1R12A,PSMD7,LIG1,TK2,NUP205,GMNN,CEP290,DNA2,KNTC1,PSMA5,HIST1H3F,ORC2,HIST1H4L,UBE2E1,MASTL,PDS5A,PSMC4,MNAT1,PCM1,ITGB3BP,CDC27,ODF2,SDCCAG8,CDCA5,PPP1R12B,NUP62,CCNB2,POLD2,ORC6,AKAP9,PCNT,SPC25,PSMA2,DYNLL1,E2F5,ESCO2,PPP2R2A,LPIN3,POLD1,LIN54,PSMA6,PLK4,PSME4,NDEL1,SKA2,CDC20,TUBGCP5,STAG2,PSMB7,NEDD1,NUP155,NUP214,CDC25C,HIST1H4I,RANBP2,PSMC6,PSMD3,HIST1H3D,MCM8,VRK2,RFC1,CLASP2,PSMD6,HIST2H2AC,H3F3A,SGOL1,MAPK1,CNEP1R1,CDKN2B,DYNC1I2,MCM10,HIST1H4E,RAE1,DBF4,ERCC6L,PSMD10,CDK11B,PPP1CC,HIST1H4D,FBXO5,TOP2A,SGOL2,CDC7,KMT5A,HIST2H3D,CKS1B,BUB1,CENPQ,PSMD11,CENPM,HIST1H2BH,HSP90AA1,ORC3,GINS1,PSMB4,SKP2,RANGAP1,POLD3,BORA,HIST1H3H,MAPK3,CENPP,LEMD2,TPR,HIST1H2AE,SET,DHFR,SPC24,CEP192,UBE2C,CDC14A
R-HSA-5663205	Infectious disease	1.83936282801124e-23	-52.3500379163384	347	223	0.0708836617927527	3146	8202	23511,2071,5611,5720,404672,5606,6147,5696,6217,6134,5688,5701,6194,8907,163,6168,6227,9972,6917,5901,6882,6222,81929,6133,7311,3841,6230,9978,8731,8905,4736,5432,6165,6827,291,5719,6233,6208,9045,5690,7251,3838,27183,5705,6188,5700,6231,92421,6749,4836,6209,6884,5689,5693,6872,5440,102157402,5713,808,6138,3978,5715,11168,6125,23165,129401,811,6137,8178,9349,1938,6205,5062,5902,51606,79902,5686,6228,6154,5438,5702,6204,3981,6921,6616,6829,55048,6875,6857,5605,5685,9636,5691,9397,7520,5704,25873,4331,6130,2957,6158,1104,160,5434,23636,6416,6181,5683,51510,5879,6235,5604,6193,6156,348995,821,3303,6218,6135,5610,5687,2926,23198,57122,10213,51121,25920,6207,6881,6877,11224,5441,6923,5436,3326,5695,9525,6169,5433,6142,6232,9631,25978,8021,6203,3921,6873,905,5903,2534,7514,3839,5706,5709,6176,6173,9861,6146,1175,5711,6224,6202,6122,51497,9150,1173,6187,6908,8480,5716,567,375,9491,3105,5478,9883,6164,2962,5708,6234,6139,83860,6155,2963,5717,6143,2068,3320,130340,7314,2959,3837,5694,7296,5609,5692,7936,6171,5045,6129,6132,55690,5905,5710,6175,5430,7316,3304,6189,7175,6136,7852,3840,6210,5608,22916,6206,6152,3159,6883,6124,164,6878	NUP188,ERCC3,DNAJC3,PSME1,GTF2H5,MAP2K3,RPL23A,PSMB8,RPS16,RPL10,PSMA7,PSMC2,RPS6,AP1M1,AP2B1,RPL37A,RPS21,NUP153,TCEA1,RAN,TAF11,RPS18,SEH1L,RPL9,UBA52,KPNA5,RPS25,RBX1,RNMT,AP1S2,RPL10A,POLR2C,RPL35A,SUPT4H1,SLC25A4,PSMD13,RPS27A,RPS14,RPL14,PSMB2,TSG101,KPNA2,VPS4A,PSMC5,RPS3,PSMC1,RPS26,CHMP4C,SSRP1,NMT1,RPS15,TAF13,PSMB1,PSMB5,TAF1,POLR2K,AK6,PSMD7,CALM3,RPL15,LIG1,PSMD9,PSIP1,RPL5,NUP205,NUP35,CALR,RPL13,ELL,RPL23,EEF2,RPS11,PAK2,RANBP1,ATP6V1H,NUP85,PSMA5,RPS23,RPL26,POLR2I,PSMC3,RPS10,LIG4,TCEB1,SNAP25,SUPT5H,VPS37C,TAF4B,SYT1,MAP2K2,PSMA4,ISG15,PSMB3,NMT2,XRCC5,PSMC4,RPL36,MNAT1,RPL7A,GTF2A1,RPL28,RCC1,AP2A1,POLR2E,NUP62,MAP2K4,RPLP2,PSMA2,CHMP5,RAC1,RPS29,MAP2K1,RPS5,RPL30,NUP43,CANX,HSPA1A,RPS17,RPL11,EIF2AK2,PSMA6,GRSF1,PSME4,NUP107,PSMD14,RPL26L1,NELFB,RPS13,TAF10,TAF5,RPL35,POLR2L,TCEB2,POLR2G,HSP90AB1,PSMB7,VPS4B,RPL38,POLR2D,RPL18A,RPS27,NUP155,CHMP2B,NUP214,RPS9,RPSA,TAF2,CCNT2,RANBP2,FYN,XPO1,KPNA3,PSMC6,PSMD3,RPLP1,RPL36A,PSMD6,RPL22,AP2S1,PSMD5,RPS20,RPS8,RPL3,NELFCD,CTDP1,AP2M1,RPS2,TBP,RAE1,PSMD10,B2M,ARF1,PSMF1,HLA-A,PPIA,POM121,RPL34,GTF2F1,PSMD2,RPS28,RPL17,TAF3,RPL27,GTF2F2,PSMD11,RPL19,ERCC2,HSP90AA1,AP1S3,UBB,GTF2B,KPNB1,PSMB6,TXNRD1,MAP2K7,PSMB4,NELFE,RPL41,FURIN,RPL7,RPL8,PACS1,RANGAP1,PSMD4,RPLP0,POLR2A,UBC,HSPA1B,RPS3A,TPR,RPL12,CXCR4,KPNA4,RPS15A,MAP2K6,NCBP2,RPS12,RPL24,HMGA1,TAF12,RPL4,AP1G1,TAF6
R-HSA-168255	Influenza Life Cycle	4.91082790607609e-17	-37.5525040369977	136	100	0.0317863954227591	3146	8202	23511,6181,5611,6235,6193,6156,348995,821,3303,6135,6218,6147,6217,6134,2926,6194,57122,6168,6227,9972,5901,6222,51121,81929,6207,6133,11224,7311,5436,5441,6230,6169,5433,6142,9631,6232,4736,8021,6203,3921,5432,6165,5903,7514,6233,6208,9045,6176,6173,6146,6188,6231,6224,6202,6122,6209,6187,5440,8480,6138,6125,23165,129401,9883,6164,2962,811,6137,9349,6234,6139,6205,6155,2963,6143,3320,79902,6228,3837,6154,5438,6171,6129,6132,6204,6175,5430,3304,25873,6189,6130,7175,6136,6158,6210,5434,23636,6206,6152,6124	NUP188,RPLP2,DNAJC3,RPS29,RPS5,RPL30,NUP43,CANX,HSPA1A,RPL11,RPS17,RPL23A,RPS16,RPL10,GRSF1,RPS6,NUP107,RPL37A,RPS21,NUP153,RAN,RPS18,RPL26L1,SEH1L,RPS13,RPL9,RPL35,UBA52,POLR2G,POLR2L,RPS25,RPL38,POLR2D,RPL18A,NUP155,RPS27,RPL10A,NUP214,RPS9,RPSA,POLR2C,RPL35A,RANBP2,XPO1,RPS27A,RPS14,RPL14,RPLP1,RPL36A,RPL22,RPS3,RPS26,RPS20,RPS8,RPL3,RPS15,RPS2,POLR2K,RAE1,RPL15,RPL5,NUP205,NUP35,POM121,RPL34,GTF2F1,CALR,RPL13,RPL23,RPS28,RPL17,RPS11,RPL27,GTF2F2,RPL19,HSP90AA1,NUP85,RPS23,KPNB1,RPL26,POLR2I,RPL41,RPL7,RPL8,RPS10,RPLP0,POLR2A,HSPA1B,RPL36,RPS3A,RPL7A,TPR,RPL12,RPL28,RPS15A,POLR2E,NUP62,RPS12,RPL24,RPL4
R-HSA-168254	Influenza Infection	5.80010824310209e-17	-37.3860700009167	147	106	0.0336935791481246	3146	8202	23511,6181,5611,6235,6193,6156,348995,821,3303,6135,6218,6147,6217,5610,6134,2926,6194,57122,6168,6227,9972,5901,6222,51121,81929,6207,6133,11224,7311,3841,5436,5441,6230,6169,5433,6142,9631,6232,4736,8021,6203,3921,5432,6165,5903,7514,3839,6233,6208,9045,6176,6173,3838,6146,6188,6231,6224,6202,6122,6209,6187,5440,8480,6138,6125,23165,129401,9883,6164,2962,811,6137,9349,6234,6139,6205,6155,2963,6143,3320,79902,6228,3837,6154,5438,6171,6129,6132,6204,6175,9636,5430,3304,25873,6189,6130,7175,6136,3840,6158,6210,5434,23636,6206,6152,6124	NUP188,RPLP2,DNAJC3,RPS29,RPS5,RPL30,NUP43,CANX,HSPA1A,RPL11,RPS17,RPL23A,RPS16,EIF2AK2,RPL10,GRSF1,RPS6,NUP107,RPL37A,RPS21,NUP153,RAN,RPS18,RPL26L1,SEH1L,RPS13,RPL9,RPL35,UBA52,KPNA5,POLR2G,POLR2L,RPS25,RPL38,POLR2D,RPL18A,NUP155,RPS27,RPL10A,NUP214,RPS9,RPSA,POLR2C,RPL35A,RANBP2,XPO1,KPNA3,RPS27A,RPS14,RPL14,RPLP1,RPL36A,KPNA2,RPL22,RPS3,RPS26,RPS20,RPS8,RPL3,RPS15,RPS2,POLR2K,RAE1,RPL15,RPL5,NUP205,NUP35,POM121,RPL34,GTF2F1,CALR,RPL13,RPL23,RPS28,RPL17,RPS11,RPL27,GTF2F2,RPL19,HSP90AA1,NUP85,RPS23,KPNB1,RPL26,POLR2I,RPL41,RPL7,RPL8,RPS10,RPLP0,ISG15,POLR2A,HSPA1B,RPL36,RPS3A,RPL7A,TPR,RPL12,KPNA4,RPL28,RPS15A,POLR2E,NUP62,RPS12,RPL24,RPL4
R-HSA-1643685	Disease	5.93698600512451e-17	-37.3627449828432	657	353	0.112205975842339	3146	8202	11116,23511,7249,8805,102,5611,8454,5720,6777,1488,404672,5519,6147,23493,1387,6217,6134,5688,6194,8907,163,9972,6227,6882,611,10818,81929,31,64223,6133,7311,8731,208,8905,842,1523,5432,6165,5335,6827,4087,291,5719,112812,6233,6208,399687,9045,4254,5527,3065,2932,6188,2549,3066,6749,4836,5689,5440,102157402,83464,5715,11168,129401,811,6137,51564,5902,79902,6228,6154,139285,5702,6204,6616,6875,5605,5685,5691,7520,6158,2957,160,9611,6416,2033,685,5879,5507,1147,324,348995,3303,9372,10675,5610,6464,2926,57122,10213,1027,253260,51121,5970,11052,25920,6881,5441,2931,8322,3326,9525,6169,5433,6232,10014,2260,8660,6873,905,5529,2534,7514,9759,51009,10046,6176,6173,148022,5711,6224,6187,1173,6908,8325,567,2309,9491,3105,5478,9883,2962,22938,5708,6139,83860,2232,5781,6143,2065,2068,7314,5694,5170,5096,2648,5609,6654,5295,5045,6129,6132,55690,54492,5710,166785,5430,7316,6136,5091,6776,6152,3159,7855,6878,142678,2071,56922,1026,10013,6382,5606,4552,5696,1499,51135,5701,5296,5664,6168,6917,5901,6222,26127,3841,6230,51107,9978,4736,3417,5690,7251,3838,27183,5705,5528,5700,6231,92421,6209,6884,5693,6872,64840,5713,808,6138,3978,83933,7270,6125,23165,57534,8178,9349,1938,6205,5062,4040,51606,9794,5686,5438,8841,3981,6921,84447,55048,6829,6857,9636,9397,6934,25873,5704,4331,6130,1104,5434,2069,23636,6907,1487,114609,25974,54567,6181,2475,5683,51510,6235,5604,6193,6156,2064,821,8658,2230,6218,6135,5687,4193,182,3551,23198,8503,4791,55534,6207,6877,11224,79412,6923,5436,207,5695,6142,9631,25978,8021,6203,3921,4088,5903,3839,5706,5709,9861,6146,23385,4089,1175,6202,6122,51497,9150,8480,79109,5716,375,1452,6164,6234,6155,2963,5717,3320,130340,2959,6774,3837,6199,7296,3280,6868,1024,5692,4303,7936,3164,6171,5905,10333,222236,6175,3304,22943,6189,2885,7175,7852,3840,221914,6210,5608,22916,6206,6883,6124,3516,4793,164,3265	FGFR1OP,NUP188,TSC2,TRIM24,ADAM10,DNAJC3,CUL1,PSME1,STAT5B,CTBP2,GTF2H5,PPP2R1B,RPL23A,HEY2,CREBBP,RPS16,RPL10,PSMA7,RPS6,AP1M1,AP2B1,NUP153,RPS21,TAF11,OPN1SW,FRS2,SEH1L,ACACA,MLST8,RPL9,UBA52,RNMT,AKT2,AP1S2,CASP9,CUX1,POLR2C,RPL35A,PLCG1,SUPT4H1,SMAD2,SLC25A4,PSMD13,FDX1L,RPS27A,RPS14,MYO18A,RPL14,KITLG,PPP2R5C,HDAC1,GSK3B,RPS3,GAB1,HDAC2,SSRP1,NMT1,PSMB1,POLR2K,AK6,APH1B,PSMD9,PSIP1,NUP35,CALR,RPL13,HDAC7,RANBP1,NUP85,RPS23,RPL26,AMER1,PSMC3,RPS10,SNAP25,TAF4B,MAP2K2,PSMA4,PSMB3,XRCC5,RPL28,GTF2A1,AP2A1,NCOR1,MAP2K4,EP300,BTC,RAC1,PPP1R3C,CHUK,APC,NUP43,HSPA1A,ZFYVE9,CSPG5,EIF2AK2,SHC1,GRSF1,NUP107,PSMD14,CDKN1B,RICTOR,RPL26L1,RELA,CPSF6,NELFB,TAF10,POLR2L,GSK3A,FZD4,HSP90AB1,VPS4B,RPL38,POLR2D,RPS27,HDAC5,FGFR1,IRS2,TAF2,CCNT2,PPP2R5E,FYN,XPO1,HDAC4,DERL2,MAMLD1,RPLP1,RPL36A,TICAM1,PSMD5,RPS20,RPS2,AP2M1,TBP,FZD8,B2M,FOXO3,PSMF1,HLA-A,PPIA,POM121,GTF2F1,SNW1,PSMD2,RPL17,TAF3,FDXR,PTPN11,RPL19,ERBB3,ERCC2,UBB,PSMB6,PDPK1,PCCB,KAT2A,MAP2K7,SOS1,PIK3R1,FURIN,RPL7,RPL8,PACS1,NEURL1B,PSMD4,MMAA,POLR2A,UBC,RPL12,PC,STAT5A,RPL24,HMGA1,FZD5,TAF6,MIB2,ERCC3,MCCC1,CDKN1A,HDAC6,SDC1,MAP2K3,MTRR,PSMB8,CTNNB1,IRAK4,PSMC2,PIK3R2,PSEN2,RPL37A,TCEA1,RAN,RPS18,FGFR1OP2,KPNA5,RPS25,APH1A,RBX1,RPL10A,IDH1,PSMB2,TSG101,KPNA2,VPS4A,PSMC5,PPP2R5D,PSMC1,RPS26,CHMP4C,RPS15,TAF13,PSMB5,TAF1,PORCN,PSMD7,CALM3,RPL15,LIG1,HDAC10,TTF1,RPL5,NUP205,MIB1,ELL,RPL23,EEF2,RPS11,PAK2,LRP6,ATP6V1H,MAML1,PSMA5,POLR2I,HDAC3,LIG4,TCEB1,SYVN1,VPS37C,SUPT5H,SYT1,ISG15,NMT2,TCF7L2,RPL36,PSMC4,MNAT1,RPL7A,RCC1,POLR2E,EREG,NUP62,TBL1X,CTBP1,TIRAP,MMACHC,DLL4,RPLP2,MTOR,PSMA2,CHMP5,RPS29,MAP2K1,RPS5,RPL30,ERBB2,CANX,TNKS,FDX1,RPS17,RPL11,PSMA6,MDM2,JAG1,IKBKB,PSME4,PIK3R3,NFKB2,MAML3,RPS13,TAF5,RPL35,KREMEN2,TCEB2,POLR2G,AKT1,PSMB7,RPL18A,NUP155,CHMP2B,NUP214,RPS9,RPSA,SMAD3,RANBP2,KPNA3,PSMC6,PSMD3,PSMD6,RPL22,NCSTN,SMAD4,AP2S1,RPS8,RPL3,NELFCD,CTDP1,RAE1,MAPKAP1,PSMD10,ARF1,CSNK1A1,RPL34,RPS28,RPL27,GTF2F2,PSMD11,HSP90AA1,AP1S3,GTF2B,STAT3,KPNB1,RPS6KB2,TXNRD1,HES1,ADAM17,CDK8,PSMB4,FOXO4,NELFE,NR4A1,RPL41,RANGAP1,TLR6,NAPEPLD,RPLP0,HSPA1B,DKK1,RPS3A,GRB2,TPR,CXCR4,KPNA4,GPC2,RPS15A,MAP2K6,NCBP2,RPS12,TAF12,RPL4,RBPJ,NFKBIB,AP1G1,HRAS
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	7.44809424204102e-17	-37.1359883876688	105	82	0.0260648442466624	3146	8202	6181,1964,6235,6193,6156,3646,6135,6218,6147,6217,6134,6194,6168,6227,8665,6222,1983,51121,1977,6207,6133,11224,7311,6230,8669,6169,6142,6232,4736,6203,8666,8661,3921,8667,27335,6165,1981,6233,6208,9045,6176,6173,6146,8662,6188,6231,6202,6122,6224,6209,6187,6138,6125,6164,6137,9349,6234,6139,6205,6155,6143,6228,6154,1974,6171,6129,6204,6132,9669,7458,6175,25873,6189,6130,6136,6158,6210,1968,1965,6206,6152,6124	RPLP2,EIF1AX,RPS29,RPS5,RPL30,EIF3E,RPL11,RPS17,RPL23A,RPS16,RPL10,RPS6,RPL37A,RPS21,EIF3F,RPS18,EIF5,RPL26L1,EIF4E,RPS13,RPL9,RPL35,UBA52,RPS25,EIF3J,RPL38,RPL18A,RPS27,RPL10A,RPS9,EIF3G,EIF3A,RPSA,EIF3H,EIF3K,RPL35A,EIF4G1,RPS27A,RPS14,RPL14,RPLP1,RPL36A,RPL22,EIF3B,RPS3,RPS26,RPS8,RPL3,RPS20,RPS15,RPS2,RPL15,RPL5,RPL34,RPL13,RPL23,RPS28,RPL17,RPS11,RPL27,RPL19,RPS23,RPL26,EIF4A2,RPL41,RPL7,RPS10,RPL8,EIF5B,EIF4H,RPLP0,RPL36,RPS3A,RPL7A,RPL12,RPL28,RPS15A,EIF2S3,EIF2S1,RPS12,RPL24,RPL4
R-HSA-72737	Cap-dependent Translation Initiation	8.55710615377009e-17	-36.9971845140507	112	86	0.0273363000635728	3146	8202	6181,1964,6235,6193,6156,3646,6135,6218,6147,6217,6134,6194,6168,6227,8665,6222,1983,51121,1977,6207,6133,11224,7311,6230,8669,6169,6142,6232,4736,6203,8666,8661,3921,8667,27335,6165,1981,6233,1978,6208,1967,9045,6176,6173,6146,8662,6188,6231,6202,6122,6224,6209,6187,6138,6125,6164,6137,9349,6234,6139,6205,6155,6143,26986,6228,6154,1974,6171,6129,6132,6204,9669,7458,6175,25873,6189,6130,6136,6158,6210,1968,1965,8892,6206,6152,6124	RPLP2,EIF1AX,RPS29,RPS5,RPL30,EIF3E,RPL11,RPS17,RPL23A,RPS16,RPL10,RPS6,RPL37A,RPS21,EIF3F,RPS18,EIF5,RPL26L1,EIF4E,RPS13,RPL9,RPL35,UBA52,RPS25,EIF3J,RPL38,RPL18A,RPS27,RPL10A,RPS9,EIF3G,EIF3A,RPSA,EIF3H,EIF3K,RPL35A,EIF4G1,RPS27A,EIF4EBP1,RPS14,EIF2B1,RPL14,RPLP1,RPL36A,RPL22,EIF3B,RPS3,RPS26,RPS8,RPL3,RPS20,RPS15,RPS2,RPL15,RPL5,RPL34,RPL13,RPL23,RPS28,RPL17,RPS11,RPL27,RPL19,PABPC1,RPS23,RPL26,EIF4A2,RPL41,RPL7,RPL8,RPS10,EIF5B,EIF4H,RPLP0,RPL36,RPS3A,RPL7A,RPL12,RPL28,RPS15A,EIF2S3,EIF2S1,EIF2B2,RPS12,RPL24,RPL4
R-HSA-72613	Eukaryotic Translation Initiation	8.55710615377009e-17	-36.9971845140507	112	86	0.0273363000635728	3146	8202	6181,1964,6235,6193,6156,3646,6135,6218,6147,6217,6134,6194,6168,6227,8665,6222,1983,51121,1977,6207,6133,11224,7311,6230,8669,6169,6142,6232,4736,6203,8666,8661,3921,8667,27335,6165,1981,6233,1978,6208,1967,9045,6176,6173,6146,8662,6188,6231,6202,6122,6224,6209,6187,6138,6125,6164,6137,9349,6234,6139,6205,6155,6143,26986,6228,6154,1974,6171,6129,6132,6204,9669,7458,6175,25873,6189,6130,6136,6158,6210,1968,1965,8892,6206,6152,6124	RPLP2,EIF1AX,RPS29,RPS5,RPL30,EIF3E,RPL11,RPS17,RPL23A,RPS16,RPL10,RPS6,RPL37A,RPS21,EIF3F,RPS18,EIF5,RPL26L1,EIF4E,RPS13,RPL9,RPL35,UBA52,RPS25,EIF3J,RPL38,RPL18A,RPS27,RPL10A,RPS9,EIF3G,EIF3A,RPSA,EIF3H,EIF3K,RPL35A,EIF4G1,RPS27A,EIF4EBP1,RPS14,EIF2B1,RPL14,RPLP1,RPL36A,RPL22,EIF3B,RPS3,RPS26,RPS8,RPL3,RPS20,RPS15,RPS2,RPL15,RPL5,RPL34,RPL13,RPL23,RPS28,RPL17,RPS11,RPL27,RPL19,PABPC1,RPS23,RPL26,EIF4A2,RPL41,RPL7,RPL8,RPS10,EIF5B,EIF4H,RPLP0,RPL36,RPS3A,RPL7A,RPL12,RPL28,RPS15A,EIF2S3,EIF2S1,EIF2B2,RPS12,RPL24,RPL4
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	1.54060417466895e-16	-36.4091868272034	104	81	0.0257469802924348	3146	8202	6181,1964,6235,6193,6156,3646,6135,6218,6147,6217,6134,6194,6168,6227,8665,6222,51121,1977,6207,6133,11224,7311,6230,8669,6169,6142,6232,4736,6203,8666,8661,3921,8667,27335,6165,1981,6233,6208,9045,6176,6173,6146,8662,6188,6231,6202,6122,6224,6209,6187,6138,6125,6164,6137,9349,6234,6139,6205,6155,6143,26986,6228,6154,1974,6171,6129,6204,6132,7458,6175,25873,6189,6130,6136,6158,6210,1968,1965,6206,6152,6124	RPLP2,EIF1AX,RPS29,RPS5,RPL30,EIF3E,RPL11,RPS17,RPL23A,RPS16,RPL10,RPS6,RPL37A,RPS21,EIF3F,RPS18,RPL26L1,EIF4E,RPS13,RPL9,RPL35,UBA52,RPS25,EIF3J,RPL38,RPL18A,RPS27,RPL10A,RPS9,EIF3G,EIF3A,RPSA,EIF3H,EIF3K,RPL35A,EIF4G1,RPS27A,RPS14,RPL14,RPLP1,RPL36A,RPL22,EIF3B,RPS3,RPS26,RPS8,RPL3,RPS20,RPS15,RPS2,RPL15,RPL5,RPL34,RPL13,RPL23,RPS28,RPL17,RPS11,RPL27,RPL19,PABPC1,RPS23,RPL26,EIF4A2,RPL41,RPL7,RPS10,RPL8,EIF4H,RPLP0,RPL36,RPS3A,RPL7A,RPL12,RPL28,RPS15A,EIF2S3,EIF2S1,RPS12,RPL24,RPL4
R-HSA-2555396	Mitotic Metaphase and Anaphase	2.5905466256593e-16	-35.8894925820836	173	119	0.0378258105530833	3146	8202	57405,5683,5048,9232,5520,5720,11004,348995,5519,79003,64682,9183,5696,25909,5687,5688,5701,51529,10393,57122,10213,23198,8379,51434,7321,81929,7112,23141,81565,1058,7311,348235,991,5695,10735,64105,6232,9212,8697,79682,3796,5903,5529,7514,79980,25936,5719,6233,5706,5709,4085,8243,7444,5527,5690,23122,5705,9861,151648,5700,5528,5711,51433,6396,5689,5693,54821,5713,5716,5715,5501,9491,4000,9793,26271,5708,55920,9126,2010,151246,55166,5717,699,9735,79019,7314,79902,5686,10726,5694,11130,5692,10274,5702,29882,5905,5710,220134,5685,5691,7316,7324,5704,23244,401541,221496,6249,81930,23421,996,23063,23592,113130,147841,54820,57082,3619,11065,9700	SPC25,PSMA2,PAFAH1B1,PTTG1,PPP2R2A,PSME1,KIF2C,NUP43,PPP2R1B,MIS12,ANAPC1,ZW10,PSMB8,AHCTF1,PSMA6,PSMA7,PSMC2,ANAPC11,ANAPC10,NUP107,PSMD14,PSME4,MAD1L1,ANAPC7,UBE2D1,SEH1L,TMPO,ANKLE2,NDEL1,CENPA,UBA52,SKA2,CDC20,PSMB7,STAG2,CENPK,RPS27,AURKB,CDC23,CENPU,KIF2A,RANBP2,PPP2R5E,XPO1,DSN1,NSL1,PSMD13,RPS27A,PSMC6,PSMD3,MAD2L1,SMC1A,VRK2,PPP2R5C,PSMB2,CLASP2,PSMC5,PSMD6,SGOL1,PSMC1,PPP2R5D,PSMD5,ANAPC5,SEC13,PSMB1,PSMB5,ERCC6L,PSMD7,PSMD10,PSMD9,PPP1CC,PSMF1,LMNA,CKAP5,FBXO5,PSMD2,RCC2,SMC3,EMD,SGOL2,CENPQ,PSMD11,BUB1,KNTC1,CENPM,UBB,NUP85,PSMA5,NUDC,PSMB6,ZWINT,PSMB4,STAG1,PSMC3,ANAPC2,RANGAP1,PSMD4,SKA1,PSMA4,PSMB3,UBC,UBE2E1,PSMC4,PDS5A,CENPP,LEMD2,CLIP1,KIF18A,ITGB3BP,CDC27,WAPL,LEMD3,CDCA5,SPC24,NDE1,CASC5,INCENP,UBE2C,ESPL1
R-HSA-72766	Translation	4.62770613168969e-16	-35.3093001784957	146	104	0.0330578512396694	3146	8202	6181,1964,6235,6193,6156,3646,6135,6218,6745,6147,6217,6134,6194,6168,6227,8665,6222,1983,51121,1977,23471,6207,55176,6731,6133,11224,7311,6734,6230,8669,6169,6142,6232,4736,6203,8666,8661,3921,8667,27335,6165,1981,1650,29927,6233,1978,6208,1967,9045,6176,6173,6747,6146,8662,6188,6231,6224,6202,6122,6209,6187,6138,6748,6728,1915,6125,6164,6137,9349,6234,1938,6139,6205,6155,6729,6143,26986,1936,6228,6154,1974,6171,6129,6132,6204,6746,9669,7458,6175,25873,6189,6130,6726,6136,6158,6210,1968,6730,8892,1965,6206,6152,6124,6727	RPLP2,EIF1AX,RPS29,RPS5,RPL30,EIF3E,RPL11,RPS17,SSR1,RPL23A,RPS16,RPL10,RPS6,RPL37A,RPS21,EIF3F,RPS18,EIF5,RPL26L1,EIF4E,TRAM1,RPS13,SEC61A2,SRP72,RPL9,RPL35,UBA52,SRPR,RPS25,EIF3J,RPL38,RPL18A,RPS27,RPL10A,RPS9,EIF3G,EIF3A,RPSA,EIF3H,EIF3K,RPL35A,EIF4G1,DDOST,SEC61A1,RPS27A,EIF4EBP1,RPS14,EIF2B1,RPL14,RPLP1,RPL36A,SSR3,RPL22,EIF3B,RPS3,RPS26,RPS20,RPS8,RPL3,RPS15,RPS2,RPL15,SSR4,SRP19,EEF1A1,RPL5,RPL34,RPL13,RPL23,RPS28,EEF2,RPL17,RPS11,RPL27,SRP54,RPL19,PABPC1,EEF1D,RPS23,RPL26,EIF4A2,RPL41,RPL7,RPL8,RPS10,SSR2,EIF5B,EIF4H,RPLP0,RPL36,RPS3A,RPL7A,SRP9,RPL12,RPL28,RPS15A,EIF2S3,SRP68,EIF2B2,EIF2S1,RPS12,RPL24,RPL4,SRP14
R-HSA-68882	Mitotic Anaphase	4.74058694740376e-16	-35.2852005312977	172	118	0.0375079465988557	3146	8202	57405,5683,5048,9232,5520,5720,11004,348995,5519,79003,64682,9183,5696,25909,5687,5688,5701,51529,10393,57122,10213,23198,8379,51434,7321,81929,7112,23141,81565,1058,7311,348235,991,5695,10735,64105,6232,9212,8697,79682,3796,5903,5529,7514,79980,25936,5719,6233,5706,5709,4085,8243,7444,5527,5690,23122,5705,9861,151648,5700,5528,5711,51433,6396,5689,5693,54821,5713,5716,5715,5501,9491,4000,9793,5708,55920,9126,2010,151246,55166,5717,699,9735,79019,7314,79902,5686,10726,5694,11130,5692,10274,5702,29882,5905,5710,220134,5685,5691,7316,7324,5704,23244,401541,221496,6249,81930,23421,996,23063,23592,113130,147841,54820,57082,3619,11065,9700	SPC25,PSMA2,PAFAH1B1,PTTG1,PPP2R2A,PSME1,KIF2C,NUP43,PPP2R1B,MIS12,ANAPC1,ZW10,PSMB8,AHCTF1,PSMA6,PSMA7,PSMC2,ANAPC11,ANAPC10,NUP107,PSMD14,PSME4,MAD1L1,ANAPC7,UBE2D1,SEH1L,TMPO,ANKLE2,NDEL1,CENPA,UBA52,SKA2,CDC20,PSMB7,STAG2,CENPK,RPS27,AURKB,CDC23,CENPU,KIF2A,RANBP2,PPP2R5E,XPO1,DSN1,NSL1,PSMD13,RPS27A,PSMC6,PSMD3,MAD2L1,SMC1A,VRK2,PPP2R5C,PSMB2,CLASP2,PSMC5,PSMD6,SGOL1,PSMC1,PPP2R5D,PSMD5,ANAPC5,SEC13,PSMB1,PSMB5,ERCC6L,PSMD7,PSMD10,PSMD9,PPP1CC,PSMF1,LMNA,CKAP5,PSMD2,RCC2,SMC3,EMD,SGOL2,CENPQ,PSMD11,BUB1,KNTC1,CENPM,UBB,NUP85,PSMA5,NUDC,PSMB6,ZWINT,PSMB4,STAG1,PSMC3,ANAPC2,RANGAP1,PSMD4,SKA1,PSMA4,PSMB3,UBC,UBE2E1,PSMC4,PDS5A,CENPP,LEMD2,CLIP1,KIF18A,ITGB3BP,CDC27,WAPL,LEMD3,CDCA5,SPC24,NDE1,CASC5,INCENP,UBE2C,ESPL1
R-HSA-168273	Influenza Viral RNA Transcription and Replication	9.69000837761271e-16	-34.5702661974397	127	93	0.0295613477431659	3146	8202	23511,6181,5611,6235,6193,6156,348995,6135,6218,6147,6217,6134,2926,6194,57122,6168,6227,9972,6222,51121,81929,6207,6133,11224,7311,5436,5441,6230,6169,5433,6142,9631,6232,4736,8021,6203,3921,5432,6165,5903,6233,6208,9045,6176,6173,6146,6188,6231,6224,6202,6122,6209,6187,5440,8480,6138,6125,23165,9883,129401,6164,2962,6137,9349,6234,6139,6205,6155,2963,6143,3320,79902,6228,6154,5438,6171,6129,6132,6204,6175,5430,25873,6189,6130,7175,6136,6158,6210,5434,23636,6206,6152,6124	NUP188,RPLP2,DNAJC3,RPS29,RPS5,RPL30,NUP43,RPL11,RPS17,RPL23A,RPS16,RPL10,GRSF1,RPS6,NUP107,RPL37A,RPS21,NUP153,RPS18,RPL26L1,SEH1L,RPS13,RPL9,RPL35,UBA52,POLR2G,POLR2L,RPS25,RPL38,POLR2D,RPL18A,NUP155,RPS27,RPL10A,NUP214,RPS9,RPSA,POLR2C,RPL35A,RANBP2,RPS27A,RPS14,RPL14,RPLP1,RPL36A,RPL22,RPS3,RPS26,RPS20,RPS8,RPL3,RPS15,RPS2,POLR2K,RAE1,RPL15,RPL5,NUP205,POM121,NUP35,RPL34,GTF2F1,RPL13,RPL23,RPS28,RPL17,RPS11,RPL27,GTF2F2,RPL19,HSP90AA1,NUP85,RPS23,RPL26,POLR2I,RPL41,RPL7,RPL8,RPS10,RPLP0,POLR2A,RPL36,RPS3A,RPL7A,TPR,RPL12,RPL28,RPS15A,POLR2E,NUP62,RPS12,RPL24,RPL4
R-HSA-72689	Formation of a pool of free 40S subunits	1.11892894834368e-15	-34.4264044632683	94	74	0.0235219326128417	3146	8202	6181,1964,6235,6193,6156,3646,6135,6218,6147,6217,6134,6194,6168,6227,8665,6222,51121,6207,6133,7311,11224,6230,8669,6169,6142,6232,4736,6203,8666,8661,8667,3921,27335,6165,6233,6208,9045,6176,6173,6146,8662,6188,6231,6202,6122,6224,6209,6187,6138,6125,6164,6137,9349,6234,6139,6205,6155,6143,6228,6154,6171,6204,6132,6129,6175,25873,6189,6130,6136,6158,6210,6206,6124,6152	RPLP2,EIF1AX,RPS29,RPS5,RPL30,EIF3E,RPL11,RPS17,RPL23A,RPS16,RPL10,RPS6,RPL37A,RPS21,EIF3F,RPS18,RPL26L1,RPS13,RPL9,UBA52,RPL35,RPS25,EIF3J,RPL38,RPL18A,RPS27,RPL10A,RPS9,EIF3G,EIF3A,EIF3H,RPSA,EIF3K,RPL35A,RPS27A,RPS14,RPL14,RPLP1,RPL36A,RPL22,EIF3B,RPS3,RPS26,RPS8,RPL3,RPS20,RPS15,RPS2,RPL15,RPL5,RPL34,RPL13,RPL23,RPS28,RPL17,RPS11,RPL27,RPL19,RPS23,RPL26,RPL41,RPS10,RPL8,RPL7,RPLP0,RPL36,RPS3A,RPL7A,RPL12,RPL28,RPS15A,RPS12,RPL4,RPL24
R-HSA-927802	Nonsense-Mediated Decay (NMD)	1.1236776461559e-15	-34.422169476248	106	81	0.0257469802924348	3146	8202	65109,6181,6235,6193,5520,6156,6135,6147,6218,6217,23381,6134,9775,6194,6227,6168,6222,51121,65110,6207,23293,6133,7311,11224,6230,6169,10921,6142,6232,4736,6203,3921,6165,1981,6233,6208,9045,6176,6173,56006,6188,6146,6231,55181,23049,6224,6202,6122,6209,6187,9887,6138,6125,6164,6137,6234,9349,6139,6205,6155,26019,6143,26986,6228,6154,6132,6129,6171,6204,6175,6189,25873,6130,5976,6136,6210,6158,22916,6124,6206,6152	UPF3B,RPLP2,RPS29,RPS5,PPP2R2A,RPL30,RPL11,RPL23A,RPS17,RPS16,SMG5,RPL10,EIF4A3,RPS6,RPS21,RPL37A,RPS18,RPL26L1,UPF3A,RPS13,SMG6,RPL9,UBA52,RPL35,RPS25,RPL38,RNPS1,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL35A,EIF4G1,RPS27A,RPS14,RPL14,RPLP1,RPL36A,SMG9,RPS3,RPL22,RPS26,SMG8,SMG1,RPS20,RPS8,RPL3,RPS15,RPS2,SMG7,RPL15,RPL5,RPL34,RPL13,RPS28,RPL23,RPL17,RPS11,RPL27,UPF2,RPL19,PABPC1,RPS23,RPL26,RPL8,RPL7,RPL41,RPS10,RPLP0,RPS3A,RPL36,RPL7A,UPF1,RPL12,RPS15A,RPL28,NCBP2,RPL4,RPS12,RPL24
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	1.1236776461559e-15	-34.422169476248	106	81	0.0257469802924348	3146	8202	65109,6181,6235,6193,5520,6156,6135,6147,6218,6217,23381,6134,9775,6194,6227,6168,6222,51121,65110,6207,23293,6133,7311,11224,6230,6169,10921,6142,6232,4736,6203,3921,6165,1981,6233,6208,9045,6176,6173,56006,6188,6146,6231,55181,23049,6224,6202,6122,6209,6187,9887,6138,6125,6164,6137,6234,9349,6139,6205,6155,26019,6143,26986,6228,6154,6132,6129,6171,6204,6175,6189,25873,6130,5976,6136,6210,6158,22916,6124,6206,6152	UPF3B,RPLP2,RPS29,RPS5,PPP2R2A,RPL30,RPL11,RPL23A,RPS17,RPS16,SMG5,RPL10,EIF4A3,RPS6,RPS21,RPL37A,RPS18,RPL26L1,UPF3A,RPS13,SMG6,RPL9,UBA52,RPL35,RPS25,RPL38,RNPS1,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL35A,EIF4G1,RPS27A,RPS14,RPL14,RPLP1,RPL36A,SMG9,RPS3,RPL22,RPS26,SMG8,SMG1,RPS20,RPS8,RPL3,RPS15,RPS2,SMG7,RPL15,RPL5,RPL34,RPL13,RPS28,RPL23,RPL17,RPS11,RPL27,UPF2,RPL19,PABPC1,RPS23,RPL26,RPL8,RPL7,RPL41,RPS10,RPLP0,RPS3A,RPL36,RPL7A,UPF1,RPL12,RPS15A,RPL28,NCBP2,RPL4,RPS12,RPL24
R-HSA-2467813	Separation of Sister Chromatids	7.49115462437376e-15	-32.5250534538052	161	110	0.034965034965035	3146	8202	57405,5683,5048,9232,5720,11004,348995,5519,79003,64682,9183,5696,25909,5687,5688,5701,51529,10393,57122,10213,23198,8379,51434,7321,81929,81565,1058,7311,348235,991,5695,10735,64105,6232,9212,8697,79682,3796,5903,5529,7514,79980,25936,5719,6233,5706,5709,4085,8243,5527,5690,23122,5705,9861,151648,5700,5528,5711,51433,6396,5689,5693,54821,5713,5716,5715,5501,9491,9793,5708,55920,9126,151246,55166,5717,699,9735,79019,7314,79902,5686,10726,5694,11130,5692,10274,5702,29882,5905,5710,220134,5685,5691,7316,7324,5704,23244,401541,6249,81930,23421,996,23063,113130,147841,54820,57082,3619,11065,9700	SPC25,PSMA2,PAFAH1B1,PTTG1,PSME1,KIF2C,NUP43,PPP2R1B,MIS12,ANAPC1,ZW10,PSMB8,AHCTF1,PSMA6,PSMA7,PSMC2,ANAPC11,ANAPC10,NUP107,PSMD14,PSME4,MAD1L1,ANAPC7,UBE2D1,SEH1L,NDEL1,CENPA,UBA52,SKA2,CDC20,PSMB7,STAG2,CENPK,RPS27,AURKB,CDC23,CENPU,KIF2A,RANBP2,PPP2R5E,XPO1,DSN1,NSL1,PSMD13,RPS27A,PSMC6,PSMD3,MAD2L1,SMC1A,PPP2R5C,PSMB2,CLASP2,PSMC5,PSMD6,SGOL1,PSMC1,PPP2R5D,PSMD5,ANAPC5,SEC13,PSMB1,PSMB5,ERCC6L,PSMD7,PSMD10,PSMD9,PPP1CC,PSMF1,CKAP5,PSMD2,RCC2,SMC3,SGOL2,CENPQ,PSMD11,BUB1,KNTC1,CENPM,UBB,NUP85,PSMA5,NUDC,PSMB6,ZWINT,PSMB4,STAG1,PSMC3,ANAPC2,RANGAP1,PSMD4,SKA1,PSMA4,PSMB3,UBC,UBE2E1,PSMC4,PDS5A,CENPP,CLIP1,KIF18A,ITGB3BP,CDC27,WAPL,CDCA5,SPC24,NDE1,CASC5,INCENP,UBE2C,ESPL1
R-HSA-192823	Viral mRNA Translation	7.75831960431846e-15	-32.4900106300002	84	67	0.0212968849332486	3146	8202	6181,5611,6235,6193,6156,6135,6218,6147,6217,6134,2926,6194,6168,6227,6222,51121,6207,6133,7311,11224,6230,6169,6142,6232,4736,6203,3921,6165,6233,6208,9045,6176,6173,6188,6146,6231,6202,6122,6224,6209,6187,6138,6125,6164,6137,9349,6234,6139,6205,6155,6143,6228,6154,6171,6204,6132,6129,6175,25873,6189,6130,6136,6158,6210,6206,6124,6152	RPLP2,DNAJC3,RPS29,RPS5,RPL30,RPL11,RPS17,RPL23A,RPS16,RPL10,GRSF1,RPS6,RPL37A,RPS21,RPS18,RPL26L1,RPS13,RPL9,UBA52,RPL35,RPS25,RPL38,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL35A,RPS27A,RPS14,RPL14,RPLP1,RPL36A,RPS3,RPL22,RPS26,RPS8,RPL3,RPS20,RPS15,RPS2,RPL15,RPL5,RPL34,RPL13,RPL23,RPS28,RPL17,RPS11,RPL27,RPL19,RPS23,RPL26,RPL41,RPS10,RPL8,RPL7,RPLP0,RPL36,RPS3A,RPL7A,RPL12,RPL28,RPS15A,RPS12,RPL4,RPL24
R-HSA-156902	Peptide chain elongation	7.75831960431846e-15	-32.4900106300002	84	67	0.0212968849332486	3146	8202	6181,6235,6193,6156,6135,6218,6147,6217,6134,6194,6227,6168,6222,51121,6207,6133,7311,11224,6230,6169,6142,6232,4736,6203,3921,6165,6233,6208,9045,6176,6173,6188,6146,6231,6202,6122,6224,6209,6187,6138,6125,1915,6164,6137,9349,6234,1938,6139,6205,6155,6143,6228,6154,6171,6204,6132,6129,6175,25873,6189,6130,6136,6158,6210,6206,6124,6152	RPLP2,RPS29,RPS5,RPL30,RPL11,RPS17,RPL23A,RPS16,RPL10,RPS6,RPS21,RPL37A,RPS18,RPL26L1,RPS13,RPL9,UBA52,RPL35,RPS25,RPL38,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL35A,RPS27A,RPS14,RPL14,RPLP1,RPL36A,RPS3,RPL22,RPS26,RPS8,RPL3,RPS20,RPS15,RPS2,RPL15,RPL5,EEF1A1,RPL34,RPL13,RPL23,RPS28,EEF2,RPL17,RPS11,RPL27,RPL19,RPS23,RPL26,RPL41,RPS10,RPL8,RPL7,RPLP0,RPL36,RPS3A,RPL7A,RPL12,RPL28,RPS15A,RPS12,RPL4,RPL24
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	1.44468319112173e-14	-31.8683012492884	107	80	0.0254291163382072	3146	8202	6181,6235,6193,6156,6135,6218,6745,6147,6217,6134,6194,6168,6227,6222,51121,23471,6207,55176,6731,6133,11224,7311,6734,6230,6169,6142,6232,4736,6203,3921,6165,1650,29927,6233,6208,9045,6176,6173,6747,6146,6188,6231,6202,6122,6224,6209,6187,6138,6748,6728,6125,6164,6137,9349,6234,6139,6205,6155,6729,6143,6228,6154,6171,6204,6132,6129,6746,6175,25873,6189,6130,6726,6136,6158,6210,6730,6206,6124,6152,6727	RPLP2,RPS29,RPS5,RPL30,RPL11,RPS17,SSR1,RPL23A,RPS16,RPL10,RPS6,RPL37A,RPS21,RPS18,RPL26L1,TRAM1,RPS13,SEC61A2,SRP72,RPL9,RPL35,UBA52,SRPR,RPS25,RPL38,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL35A,DDOST,SEC61A1,RPS27A,RPS14,RPL14,RPLP1,RPL36A,SSR3,RPL22,RPS3,RPS26,RPS8,RPL3,RPS20,RPS15,RPS2,RPL15,SSR4,SRP19,RPL5,RPL34,RPL13,RPL23,RPS28,RPL17,RPS11,RPL27,SRP54,RPL19,RPS23,RPL26,RPL41,RPS10,RPL8,RPL7,SSR2,RPLP0,RPL36,RPS3A,RPL7A,SRP9,RPL12,RPL28,RPS15A,SRP68,RPS12,RPL4,RPL24,SRP14
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	2.34940499390486e-14	-31.3820291999026	223	141	0.0448188175460903	3146	8202	23291,84727,81559,79654,65264,55585,8454,9666,5720,9867,80176,64682,5696,5688,10193,51343,51529,5701,10393,51619,54778,23295,140459,26259,7311,10616,9978,83737,7335,127544,5719,6233,5690,51130,5705,642,5700,7323,51433,5689,5693,9039,26272,26118,140462,5713,80196,5715,7337,92912,9246,8139,9690,54926,5686,5702,6921,4591,140461,5685,5691,10425,7324,5704,10273,996,27338,9604,90933,5071,7317,5683,55284,5687,55182,8651,197131,79876,23198,10213,51434,64219,7321,140460,6923,991,5695,8452,118424,8697,23352,9021,56658,6049,5706,7336,5709,10477,9861,57154,7334,5711,51665,9320,25831,5716,9354,9491,26273,5708,55070,27252,10075,51465,6737,26046,6047,5717,11059,89910,7314,9730,7327,5694,5692,7332,6502,7328,29882,64750,5710,55236,7316,997,8453,7322,51444,93611,23376,11065,63891	FBXW11,SPSB2,TRIM11,HECTD3,UBE2Z,UBE2Q1,CUL1,DZIP3,PSME1,PJA2,SPSB1,ANAPC1,PSMB8,PSMA7,RNF41,FZR1,ANAPC11,PSMC2,ANAPC10,UBE2D4,RNF111,MGRN1,ASB6,FBXW8,UBA52,RBCK1,RBX1,ITCH,UBE2V1,RNF19B,PSMD13,RPS27A,PSMB2,ASB3,PSMC5,BLMH,PSMC1,UBE2D3,ANAPC5,PSMB1,PSMB5,UBA3,FBXO4,WSB1,ASB9,PSMD7,RNF34,PSMD9,UBE3A,UBE2Q2,UBE2L6,GAN,UBE3C,UBE2R2,PSMA5,PSMC3,TCEB1,TRIM37,ASB8,PSMA4,PSMB3,ARIH2,UBE2E1,PSMC4,STUB1,CDC27,UBE2S,RNF14,TRIM41,PARK2,UBA1,PSMA2,UBE2W,PSMA6,RNF220,SOCS1,UBR1,UBA5,PSME4,PSMD14,ANAPC7,PJA1,UBE2D1,ASB7,TCEB2,CDC20,PSMB7,CUL3,UBE2J2,CDC23,UBR4,SOCS3,TRIM39,RNF6,PSMC6,UBE2V2,PSMD3,UBE2E3,PSMD6,SMURF1,UBE2N,PSMD5,ASB1,TRIP12,HECTD1,PSMD10,UBE4A,PSMF1,FBXO3,PSMD2,DET1,KLHL20,HUWE1,UBE2J1,TRIM21,LTN1,RNF4,PSMD11,WWP1,UBE3B,UBB,VPRBP,UBE2G2,PSMB6,PSMB4,UBE2L3,SKP2,UBE2H,ANAPC2,SMURF2,PSMD4,UBA6,UBC,CDC34,CUL2,UBE2D2,RNF138,FBXO44,UFL1,UBE2C,RNF123
R-HSA-453279	Mitotic G1-G1/S phases	3.02847435671718e-14	-31.128132321835	135	95	0.0301970756516211	3146	8202	5683,1875,5520,8454,5720,1026,891,898,5519,132660,286826,1031,7465,5111,5687,890,5696,5688,5701,10213,1027,1032,1021,7311,1871,5695,6241,990,9088,983,5557,8318,5719,6233,5706,1874,5709,84515,7298,3065,5690,7029,5705,9861,1870,5700,5711,4172,55957,1030,5689,4175,5693,55388,10926,5713,5716,5715,9491,7084,26271,7153,5708,8317,896,1163,5717,7314,23595,5686,5694,993,4999,5692,5558,5422,5702,4605,6502,5710,5685,5691,7316,5704,4331,1859,5000,5426,5427,5001,7027,1719,91750,23594,1029	PSMA2,E2F5,PPP2R2A,CUL1,PSME1,CDKN1A,CCNB1,CCNE1,PPP2R1B,LIN54,LIN9,CDKN2C,WEE1,PCNA,PSMA6,CCNA2,PSMB8,PSMA7,PSMC2,PSMD14,CDKN1B,CDKN2D,CDK6,UBA52,E2F3,PSMB7,RRM2,CDC6,PKMYT1,CDK1,PRIM1,CDC45,PSMD13,RPS27A,PSMC6,E2F4,PSMD3,MCM8,TYMS,HDAC1,PSMB2,TFDP2,PSMC5,PSMD6,E2F2,PSMC1,PSMD5,MCM3,LIN37,CDKN2B,PSMB1,MCM6,PSMB5,MCM10,DBF4,PSMD7,PSMD10,PSMD9,PSMF1,TK2,FBXO5,TOP2A,PSMD2,CDC7,CCND3,CKS1B,PSMD11,UBB,ORC3,PSMA5,PSMB6,CDC25A,ORC2,PSMB4,PRIM2,POLA1,PSMC3,MYBL2,SKP2,PSMD4,PSMA4,PSMB3,UBC,PSMC4,MNAT1,DYRK1A,ORC4,POLE,POLE2,ORC5,TFDP1,DHFR,LIN52,ORC6,CDKN2A
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	4.2513827799976e-14	-30.788947011899	89	69	0.0219326128417038	3146	8202	6181,6235,6193,6156,6135,6147,6218,6217,6134,6194,6227,6168,6222,51121,6207,6133,7311,11224,6230,6169,6142,6232,4736,6203,3921,6165,1981,6233,6208,9045,6176,6173,6188,6146,6231,6202,6122,6224,6209,6187,6138,6125,6164,6137,9349,6234,6139,6205,6155,6143,26986,6228,6154,6129,6132,6171,6204,6175,6189,25873,6130,5976,6136,6210,6158,22916,6152,6124,6206	RPLP2,RPS29,RPS5,RPL30,RPL11,RPL23A,RPS17,RPS16,RPL10,RPS6,RPS21,RPL37A,RPS18,RPL26L1,RPS13,RPL9,UBA52,RPL35,RPS25,RPL38,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL35A,EIF4G1,RPS27A,RPS14,RPL14,RPLP1,RPL36A,RPS3,RPL22,RPS26,RPS8,RPL3,RPS20,RPS15,RPS2,RPL15,RPL5,RPL34,RPL13,RPL23,RPS28,RPL17,RPS11,RPL27,RPL19,PABPC1,RPS23,RPL26,RPL7,RPL8,RPL41,RPS10,RPLP0,RPS3A,RPL36,RPL7A,UPF1,RPL12,RPS15A,RPL28,NCBP2,RPL24,RPL4,RPS12
R-HSA-983169	Class I MHC mediated antigen processing & presentation	5.47245830923016e-14	-30.5364633697619	267	162	0.0514939605848697	3146	8202	23291,84727,81559,6890,79654,65264,55585,8454,9666,5720,9867,80176,64682,5696,5688,10193,51343,51529,5701,10393,51619,54778,23295,140459,55176,26259,7311,10616,9978,83737,7335,127544,5719,1535,6233,5690,51130,5705,642,5700,7323,51433,5689,5693,9871,26272,9039,26118,140462,5713,80196,3693,5715,811,7337,92912,9246,8139,9690,54926,5686,5702,6921,4591,140461,5685,5691,10425,7324,5704,10273,22872,996,27338,9604,90933,5071,7317,5683,55284,821,5687,55182,8651,197131,79876,23198,10213,6891,51434,64219,7321,140460,10802,10484,6923,991,5695,8452,118424,8697,23352,9021,56658,6049,29927,5706,7336,5709,10477,9861,57154,7334,5711,6396,51665,9320,25831,2923,5716,567,9354,9491,3105,26273,5708,55070,27252,10075,9632,51465,6047,6737,26046,5717,11059,89910,7314,9730,7327,5694,5692,7332,6502,7328,29882,64750,5710,55236,7316,51128,10427,997,8453,7322,51444,51752,93611,23376,3685,11065,63891	FBXW11,SPSB2,TRIM11,TAP1,HECTD3,UBE2Z,UBE2Q1,CUL1,DZIP3,PSME1,PJA2,SPSB1,ANAPC1,PSMB8,PSMA7,RNF41,FZR1,ANAPC11,PSMC2,ANAPC10,UBE2D4,RNF111,MGRN1,ASB6,SEC61A2,FBXW8,UBA52,RBCK1,RBX1,ITCH,UBE2V1,RNF19B,PSMD13,CYBA,RPS27A,PSMB2,ASB3,PSMC5,BLMH,PSMC1,UBE2D3,ANAPC5,PSMB1,PSMB5,SEC24D,FBXO4,UBA3,WSB1,ASB9,PSMD7,RNF34,ITGB5,PSMD9,CALR,UBE3A,UBE2Q2,UBE2L6,GAN,UBE3C,UBE2R2,PSMA5,PSMC3,TCEB1,TRIM37,ASB8,PSMA4,PSMB3,ARIH2,UBE2E1,PSMC4,STUB1,SEC31A,CDC27,UBE2S,RNF14,TRIM41,PARK2,UBA1,PSMA2,UBE2W,CANX,PSMA6,RNF220,SOCS1,UBR1,UBA5,PSME4,PSMD14,TAP2,ANAPC7,PJA1,UBE2D1,ASB7,SEC24A,SEC23A,TCEB2,CDC20,PSMB7,CUL3,UBE2J2,CDC23,UBR4,SOCS3,TRIM39,RNF6,SEC61A1,PSMC6,UBE2V2,PSMD3,UBE2E3,PSMD6,SMURF1,UBE2N,PSMD5,SEC13,ASB1,TRIP12,HECTD1,PDIA3,PSMD10,B2M,UBE4A,PSMF1,HLA-A,FBXO3,PSMD2,DET1,KLHL20,HUWE1,SEC24C,UBE2J1,RNF4,TRIM21,LTN1,PSMD11,WWP1,UBE3B,UBB,VPRBP,UBE2G2,PSMB6,PSMB4,UBE2L3,SKP2,UBE2H,ANAPC2,SMURF2,PSMD4,UBA6,UBC,SAR1B,SEC24B,CDC34,CUL2,UBE2D2,RNF138,ERAP1,FBXO44,UFL1,ITGAV,UBE2C,RNF123
R-HSA-68886	M Phase	6.11396008167612e-14	-30.4256166074722	296	176	0.0559440559440559	3146	8202	3015,23511,2029,5862,8358,8350,5720,11004,891,5519,79003,8365,64682,9183,5696,8366,5688,5701,51529,10393,8379,9972,8331,81929,7112,8352,7311,1058,23133,64105,9212,10592,983,5719,25936,6233,91754,5527,5690,5705,5700,5528,51433,5689,5693,5713,5715,23165,129401,4000,9126,2010,81876,9735,79902,5686,8968,10274,10112,5702,8368,5685,5691,7324,5704,23244,84930,23421,996,23063,23592,113130,23636,54820,3619,9133,8354,57405,5048,5683,9232,5520,348995,64900,5687,25909,8364,57122,23198,10213,51434,7321,23141,81565,348235,991,10735,5695,6232,9631,8697,5861,8021,79682,8294,3796,5903,5529,7514,79980,5706,5709,8351,4085,8243,7444,3014,23122,23383,9861,8338,3020,151648,5594,255919,5711,6396,8367,8480,54821,5716,9491,5501,8360,9883,121504,26271,9793,5708,55920,151246,387893,653604,5717,55166,699,8345,79019,29781,7314,10051,10726,5694,11130,5692,140609,29882,5905,5710,8357,220134,7316,5595,401541,221496,7175,6249,3012,23310,81930,8334,6418,147841,57082,11065,9700	H2AFZ,NUP188,ENSA,RAB2A,HIST1H3B,HIST1H3A,PSME1,KIF2C,CCNB1,PPP2R1B,MIS12,HIST1H4H,ANAPC1,ZW10,PSMB8,HIST1H4B,PSMA7,PSMC2,ANAPC11,ANAPC10,MAD1L1,NUP153,HIST1H2AJ,SEH1L,TMPO,HIST1H3C,UBA52,CENPA,PHF8,CENPK,AURKB,SMC2,CDK1,PSMD13,NSL1,RPS27A,NEK9,PPP2R5C,PSMB2,PSMC5,PSMC1,PPP2R5D,ANAPC5,PSMB1,PSMB5,PSMD7,PSMD9,NUP205,NUP35,LMNA,SMC3,EMD,RAB1B,KNTC1,NUP85,PSMA5,HIST1H3F,STAG1,KIF20A,PSMC3,HIST1H4L,PSMA4,PSMB3,UBE2E1,PSMC4,PDS5A,MASTL,ITGB3BP,CDC27,WAPL,LEMD3,CDCA5,NUP62,NDE1,INCENP,CCNB2,HIST1H3I,SPC25,PAFAH1B1,PSMA2,PTTG1,PPP2R2A,NUP43,LPIN3,PSMA6,AHCTF1,HIST1H4C,NUP107,PSME4,PSMD14,ANAPC7,UBE2D1,ANKLE2,NDEL1,SKA2,CDC20,STAG2,PSMB7,RPS27,NUP155,CDC23,RAB1A,NUP214,CENPU,HIST1H4I,KIF2A,RANBP2,PPP2R5E,XPO1,DSN1,PSMC6,PSMD3,HIST1H3D,MAD2L1,SMC1A,VRK2,H2AFX,CLASP2,MAU2,PSMD6,HIST2H2AC,H3F3A,SGOL1,MAPK1,CNEP1R1,PSMD5,SEC13,HIST1H4E,RAE1,ERCC6L,PSMD10,PSMF1,PPP1CC,HIST1H4D,POM121,HIST4H4,FBXO5,CKAP5,PSMD2,RCC2,SGOL2,KMT5A,HIST2H3D,PSMD11,CENPQ,BUB1,HIST1H2BH,CENPM,NCAPH2,UBB,SMC4,NUDC,PSMB6,ZWINT,PSMB4,NEK7,ANAPC2,RANGAP1,PSMD4,HIST1H3H,SKA1,UBC,MAPK3,CENPP,LEMD2,TPR,CLIP1,HIST1H2AE,NCAPD3,KIF18A,HIST1H2AC,SET,SPC24,CASC5,UBE2C,ESPL1
R-HSA-156842	Eukaryotic Translation Elongation	8.7151124933574e-14	-30.0711327150122	88	68	0.0216147488874762	3146	8202	6181,6235,6193,6156,6135,6218,6147,6217,6134,6194,6227,6168,6222,51121,6207,6133,7311,11224,6230,6169,6142,6232,4736,6203,3921,6165,6233,6208,9045,6176,6173,6188,6146,6231,6202,6122,6224,6209,6187,6138,6125,1915,6164,6137,9349,6234,1938,6139,6205,6155,6143,6228,1936,6154,6171,6204,6132,6129,6175,25873,6189,6130,6136,6158,6210,6206,6124,6152	RPLP2,RPS29,RPS5,RPL30,RPL11,RPS17,RPL23A,RPS16,RPL10,RPS6,RPS21,RPL37A,RPS18,RPL26L1,RPS13,RPL9,UBA52,RPL35,RPS25,RPL38,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL35A,RPS27A,RPS14,RPL14,RPLP1,RPL36A,RPS3,RPL22,RPS26,RPS8,RPL3,RPS20,RPS15,RPS2,RPL15,RPL5,EEF1A1,RPL34,RPL13,RPL23,RPS28,EEF2,RPL17,RPS11,RPL27,RPL19,RPS23,EEF1D,RPL26,RPL41,RPS10,RPL8,RPL7,RPLP0,RPL36,RPS3A,RPL7A,RPL12,RPL28,RPS15A,RPS12,RPL4,RPL24
R-HSA-1852241	Organelle biogenesis and maintenance	1.48713740890498e-13	-29.5367531389183	321	187	0.0594405594405594	3146	8202	11116,261734,5565,6256,10102,124995,3396,54903,26160,79738,7531,10013,9801,10884,1387,4218,582,84131,55770,10498,64792,51253,80205,2551,1454,129880,6182,84545,5571,79959,79600,983,378,55052,54460,51668,64978,64432,51264,26146,211,28957,10891,7840,11258,51106,51373,55081,65080,585,29093,9321,27241,2553,150737,55142,85302,83657,50807,80184,4751,149371,51023,55112,64976,219927,51650,8841,92104,219402,6604,79969,122704,8195,22994,10640,166379,51318,132320,51422,5108,123263,9553,79989,4957,10806,57728,60412,8481,11127,6991,6907,9611,2101,54820,11222,10142,5116,80321,79867,10383,5048,54148,8655,51263,89891,5566,8729,22948,54534,9727,4899,5147,23054,10240,740,23107,55037,10733,6742,64975,80254,1386,3054,10576,51258,4528,90480,60488,121441,4209,11232,64928,63931,7532,84100,10573,51069,28981,7818,6950,128308,51649,118487,55764,146057,51021,203068,54998,3842,1781,28977,7978,64949,506,23265,11020,84340,8766,64963,9793,403,56945,9702,79598,55835,6183,116541,79659,3320,5469,29088,64951,27077,51098,55755,7284,5465,55173,7203,117177,80173,57560,64979,51081,55125,4867	FGFR1OP,NPHP4,PRKAB2,RXRA,TSFM,MRPL10,ICT1,MKS1,IFT172,BBS10,YWHAE,HDAC6,MRPL19,MRPS30,CREBBP,RAB8A,BBS1,CEP78,EXOC2,CARM1,IFT22,MRPL37,CHD9,GABPA,CSNK1E,BBS5,MRPL12,MRPL43,PRKAG1,CEP76,TCTN1,CDK1,ARF4,MRPL20,MRPS21,HSPB11,MRPL38,MRPS25,MRPL27,TRAF3IP1,ALAS1,MRPS28,PPARGC1A,ALMS1,DCTN3,TFB1M,MRPS17,IFT57,MRPL44,BBS4,MRPL22,TRIP11,BBS9,GABPB1,TTC30B,HAUS2,FBF1,DYNLRB2,ASAP1,CEP290,NEK2,EXOC8,MRPS18C,WDR60,MRPL40,MRPL21,MRPS33,HDAC3,TTC30A,MTIF3,SMARCD3,ATAT1,MRPL52,MKKS,CEP131,EXOC5,BBS12,MRPL35,SCLT1,PRKAG2,PCM1,MTFMT,MRPL33,TTC26,ODF2,SDCCAG8,WDR19,EXOC4,OFD1,KIF3A,TCTE3,TBL1X,NCOR1,ESRRA,NDE1,MRPL3,AKAP9,PCNT,CEP70,TCTN2,TUBB4B,PAFAH1B1,MRPL39,DYNLL1,MRPL30,WDR34,PRKACA,GBF1,CCT5,MRPL50,RAB11FIP3,NRF1,PDE6D,NCOA6,MRPS31,MRPL49,MRPS27,PTCD3,PLK4,SSBP1,MRPL41,CEP63,ATF2,HCFC1,CCT2,MRPL51,MTIF2,GADD45GIP1,MRPS35,NEDD1,MEF2D,POLG2,MRPL14,MRPS14,YWHAG,ARL6,MRPL28,MRPL2,IFT81,DAP3,TCP1,MRPL55,MRPS23,CHCHD1,IFT122,TTBK2,MRPS16,TUBB,AURKAIP1,TNPO1,DYNC1I2,MRPL42,MTERF1,MRPS26,ATP5B,EXOC7,IFT27,GFM2,RAB11A,MRPS11,CKAP5,ARL3,MRPS22,CEP57,CEP97,CENPJ,MRPS12,MRPL54,DYNC2H1,HSP90AA1,MED1,MRPL15,MRPS24,B9D1,IFT52,CDK5RAP2,TUFM,PPARA,MRPS10,CCT3,RAB3IP,IFT74,IFT80,MRPL36,MRPS7,CEP192,NPHP1
R-HSA-72764	Eukaryotic Translation Termination	7.35336719887194e-13	-27.9384478783083	85	65	0.0206611570247934	3146	8202	6181,6235,6193,6156,6135,6218,6147,6217,6134,6194,6227,6168,6222,51121,6207,6133,7311,11224,6230,6169,6142,6232,4736,6203,3921,6165,6233,6208,9045,6176,6173,6188,6146,6231,6202,6122,6224,6209,6187,6138,6125,6164,6137,9349,6234,6139,6205,6155,6143,6228,6154,6204,6132,6129,6171,6175,25873,6189,6130,6136,6158,6210,6206,6124,6152	RPLP2,RPS29,RPS5,RPL30,RPL11,RPS17,RPL23A,RPS16,RPL10,RPS6,RPS21,RPL37A,RPS18,RPL26L1,RPS13,RPL9,UBA52,RPL35,RPS25,RPL38,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL35A,RPS27A,RPS14,RPL14,RPLP1,RPL36A,RPS3,RPL22,RPS26,RPS8,RPL3,RPS20,RPS15,RPS2,RPL15,RPL5,RPL34,RPL13,RPL23,RPS28,RPL17,RPS11,RPL27,RPL19,RPS23,RPL26,RPS10,RPL8,RPL7,RPL41,RPLP0,RPL36,RPS3A,RPL7A,RPL12,RPL28,RPS15A,RPS12,RPL4,RPL24
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	8.10540710795193e-13	-27.8410748257611	153	102	0.0324221233312142	3146	8202	9410,55599,23511,65109,5356,10978,6636,6635,348995,53981,5093,220988,83443,10992,3181,6427,29894,10286,84844,57721,6429,57122,3191,9972,3192,1977,5094,81929,10291,23020,6629,5436,5441,5725,3185,5433,3183,10921,7884,9631,51585,11100,10907,8021,10421,55954,5432,5903,11051,10236,7307,8243,9128,2521,6637,6627,10594,51362,5440,8480,10250,1660,10949,10482,3187,10081,154007,9883,23165,129401,2962,22826,56259,9343,2963,3184,4904,24148,79902,4670,9295,5438,1479,51639,9589,6430,8175,6626,5430,23450,9416,10181,7175,5434,57819,1478,3190,23636,22916,6428,6633,51503	SNRNP40,RNPC3,NUP188,UPF3B,PLRG1,CLP1,SNRPF,SNRPE,NUP43,CPSF2,PCBP1,HNRNPA3,SF3B5,SF3B2,HNRNPA2B1,SRSF2,CPSF1,BCAS2,PHF5A,METTL14,SRSF4,NUP107,HNRNPL,NUP153,HNRNPU,EIF4E,PCBP2,SEH1L,SF3A1,SNRNP200,SNRPB2,POLR2G,POLR2L,PTBP1,HNRNPF,POLR2D,HNRNPC,RNPS1,SLBP,NUP155,PCF11,HNRNPUL1,TXNL4A,NUP214,CD2BP2,ZMAT5,POLR2C,RANBP2,NUDT21,HNRNPR,U2AF1,SMC1A,PRPF4,FUS,SNRPG,SNRPA1,PRPF8,CDC40,POLR2K,RAE1,SRRM1,DHX9,HNRNPA0,NXF1,HNRNPH1,PDCD7,SNRNP48,POM121,NUP205,NUP35,GTF2F1,DNAJC8,CTNNBL1,EFTUD2,GTF2F2,HNRNPD,YBX1,PRPF6,NUP85,HNRNPM,SRSF11,POLR2I,CSTF3,SF3B6,WTAP,SRSF5,SF3A2,SNRPA,POLR2A,SF3B3,DDX23,RBM5,TPR,POLR2E,LSM2,CSTF2,HNRNPK,NUP62,NCBP2,SRSF3,SNRPD2,CWC15
R-HSA-69620	Cell Cycle Checkpoints	1.27852956314064e-12	-27.3853104771455	179	115	0.0365543547361729	3146	8202	5883,5683,10524,5720,1026,7531,9656,891,580,898,8365,64682,7465,4193,5696,5687,8366,5688,8364,5701,51529,10393,10213,23198,8379,1027,84126,4361,51434,7321,5984,5983,7311,5810,991,5695,10971,990,672,9088,8697,5982,995,983,7532,8318,8294,5719,7336,7158,6233,5706,5709,4085,84515,3014,51720,5690,79184,5705,9861,5700,7334,5711,4172,84142,51588,51433,5689,4175,5693,55388,63967,8367,10926,5713,5716,1111,5715,9491,8360,7341,121504,5708,8317,5717,8345,23595,7314,5686,5694,993,4999,5692,5702,7468,29882,9025,5710,8368,5685,5691,7316,7324,5704,64326,5000,996,5001,7534,7533,9133,11065,2810,23594	RAD9A,PSMA2,KAT5,PSME1,CDKN1A,YWHAE,MDC1,CCNB1,BARD1,CCNE1,HIST1H4H,ANAPC1,WEE1,MDM2,PSMB8,PSMA6,HIST1H4B,PSMA7,HIST1H4C,PSMC2,ANAPC11,ANAPC10,PSMD14,PSME4,MAD1L1,CDKN1B,ATRIP,MRE11A,ANAPC7,UBE2D1,RFC4,RFC3,UBA52,RAD1,CDC20,PSMB7,YWHAQ,CDC6,BRCA1,PKMYT1,CDC23,RFC2,CDC25C,CDK1,YWHAG,CDC45,HIST1H4I,PSMD13,UBE2V2,TP53BP1,RPS27A,PSMC6,PSMD3,MAD2L1,MCM8,H2AFX,UIMC1,PSMB2,BRCC3,PSMC5,PSMD6,PSMC1,UBE2N,PSMD5,MCM3,FAM175A,PIAS4,ANAPC5,PSMB1,MCM6,PSMB5,MCM10,CLSPN,HIST1H4E,DBF4,PSMD7,PSMD10,CHEK1,PSMD9,PSMF1,HIST1H4D,SUMO1,HIST4H4,PSMD2,CDC7,PSMD11,HIST1H2BH,ORC3,UBB,PSMA5,PSMB6,CDC25A,ORC2,PSMB4,PSMC3,WHSC1,ANAPC2,RNF8,PSMD4,HIST1H4L,PSMA4,PSMB3,UBC,UBE2E1,PSMC4,RFWD2,ORC4,CDC27,ORC5,YWHAZ,YWHAH,CCNB2,UBE2C,SFN,ORC6
R-HSA-73894	DNA Repair	1.63525031362278e-12	-27.1392252262805	306	177	0.0562619198982835	3146	8202	5883,51008,84164,2071,54617,8450,2177,201254,10524,404672,580,55215,8365,55120,5111,29089,51138,8366,7516,5887,27343,54778,4361,6917,55775,2067,7311,5810,1161,9978,51548,10635,2140,672,353497,5982,5432,10401,85015,79661,9768,50813,56852,7158,6233,197342,9031,3838,2073,60,10980,63967,5440,57461,22909,3978,1111,2072,11284,3980,51514,8178,9246,8533,91442,1763,7398,125476,7353,1643,5438,11073,5531,3981,7468,8368,4350,2175,9636,7520,4331,10973,5980,79728,80198,5888,5434,7528,8467,91603,5425,124739,2033,5599,2176,9656,5424,5886,84464,890,6996,7706,8364,84126,79913,9716,23514,23583,5984,5983,5441,5436,10450,27434,5433,2189,2178,83695,9156,8294,5889,23030,7336,2074,80233,3014,199990,51720,7517,5981,79184,5536,83444,5429,4595,7334,10721,51588,84142,7508,8367,55183,322,641,80010,8360,10459,252969,7341,121504,25,6047,64708,8345,2068,7314,51455,2956,3150,10445,9318,328,5591,9025,57697,10714,5430,7316,4255,2187,5426,5427,7374,4437,79840,1642,151987	RAD9A,ASCC1,ASCC2,ERCC3,INO80,CUL4B,FANCD2,STRA13,KAT5,GTF2H5,BARD1,FANCI,HIST1H4H,FANCL,PCNA,UBE2T,COPS4,HIST1H4B,XRCC2,RAD23B,POLL,RNF111,MRE11A,TCEA1,TDP1,ERCC1,UBA52,RAD1,ERCC8,RBX1,SIRT6,RAD51AP1,EYA3,BRCA1,POLN,RFC2,POLR2C,PIAS3,USP45,NEIL1,KIAA0101,COPS7A,RAD18,TP53BP1,RPS27A,EME2,BAZ1B,KPNA2,ERCC5,ACTB,COPS6,CLSPN,POLR2K,ISY1,FAN1,LIG1,CHEK1,ERCC4,PNKP,LIG3,DTL,ELL,UBE2L6,COPS3,FAAP24,DNA2,USP1,INO80C,UFD1L,DDB2,POLR2I,TOPBP1,PPP4C,LIG4,WHSC1,HIST1H4L,MPG,FANCA,ISG15,XRCC5,MNAT1,ASCC3,REV3L,PALB2,MUS81,RAD51,POLR2E,YY1,SMARCA5,ZNF830,POLD2,USP43,EP300,MAPK8,FANCC,MDC1,POLD1,RAD23A,SLX4,CCNA2,TDG,TRIM25,HIST1H4C,ATRIP,ACTR5,AQR,SPIDR,SMUG1,RFC4,RFC3,POLR2L,POLR2G,PPIE,POLM,POLR2D,FANCG,FANCE,RHNO1,EXO1,HIST1H4I,RAD51C,KDM4B,UBE2V2,ERCC6,FAAP100,H2AFX,FAAP20,UIMC1,XRCC3,RFC1,BRCC3,PPP5C,INO80B,POLH,MUTYH,UBE2N,POLQ,PIAS4,FAM175A,XPC,HIST1H4E,RIF1,APBB1,BLM,RMI1,HIST1H4D,MAD2L2,NEIL2,SUMO1,HIST4H4,ABL1,RNF4,COPS7B,HIST1H2BH,ERCC2,UBB,REV1,MSH6,HMGN1,MCRS1,COPS2,APEX1,PRKDC,RNF8,FANCM,POLD3,POLR2A,UBC,MGMT,FANCB,POLE,POLE2,UNG,MSH3,NHEJ1,DDB1,PPP4R2
R-HSA-212436	Generic Transcription Pathway	2.43050997333845e-12	-26.7429200150234	553	290	0.0921805467260013	3146	8202	84838,7249,5565,79973,7531,125919,7587,57521,9997,1387,220992,143686,1490,7004,54778,5494,64223,80110,388536,7771,84527,7311,148213,208,55634,8239,10168,10781,4087,6233,115509,10325,3065,6341,9282,7029,7621,124411,1329,57343,84626,5562,255403,7633,54807,9968,92285,58500,162972,5915,7760,171392,170959,340385,199704,84914,84775,100289635,6604,148156,79027,155054,51422,10127,50484,51586,90338,221785,9440,353088,9611,2101,388567,29959,57541,158431,9534,387032,146434,282890,92595,285267,348327,79818,7695,147923,285971,23054,7586,117608,730087,7769,7321,90075,284370,1350,65251,80032,1353,10025,7728,10155,7532,116228,905,121274,90874,2539,80139,10046,25937,56242,197320,126068,4306,136051,353274,201514,51333,9422,51058,7755,10542,22938,81857,84924,1349,7314,374655,5469,83744,7738,7050,2648,7316,7733,22835,7027,65243,10128,126231,7767,7533,284306,7559,51204,7745,6256,285268,7692,51241,80108,22869,284459,7551,163081,285521,8463,10498,84124,7068,80205,7561,5468,147929,5571,10413,27244,199692,6009,9969,2744,163071,55663,80317,1874,90317,10795,7596,163050,58528,7323,8649,51003,7592,1327,54541,9668,84246,112950,57103,126070,339559,7625,55657,9443,9794,25799,54811,7594,91975,57677,388561,2100,81856,100131827,7025,6257,389541,9167,7534,6907,163049,5916,7571,2810,7766,126382,79744,79088,51123,353355,51276,2475,339327,1875,55659,64121,7576,54925,29079,25888,9441,284443,7539,10794,27300,55534,148103,5914,57711,207,10971,7556,7697,286075,4088,90592,84449,7566,55762,4089,162966,1030,90649,79175,7673,7376,7988,57209,1337,3726,344787,146540,55778,6667,147837,7296,1024,2908,2626,3164,7003,5465,388569,7581,115196,64750,4221,55422,51592,148254,80778,5467,58492,57335,7761,65988,1351,3516	ZNF496,TSC2,PRKAB2,ZNF442,YWHAE,ZNF543,ZNF37A,RPTOR,SCO2,CREBBP,ZNF485,SESN3,CTGF,TEAD4,RNF111,PPM1A,MLST8,ZNF614,ZNF790,ZNF112,ZNF559,UBA52,ZNF681,AKT2,KRBOX4,USP9X,ZNF197,ZNF266,SMAD2,RPS27A,ZNF689,RRAGB,HDAC1,SCO1,MED14,TFDP2,ZNF70,ZNF720,COX5B,ZNF304,KRBA1,PRKAA1,ZNF718,ZNF79,ZNF586,MED12,ZNF585B,ZNF250,ZNF550,RARB,ZNF213,ZNF675,ZNF431,ZNF517,ZNF585A,ZNF587,ZNF607,ZNF605,SMARCD3,ZNF558,ZNF655,ZNF425,PRKAG2,ZNF263,RRM2B,MED15,ZNF160,ZSCAN25,MED17,ZNF429,NCOR1,ESRRA,ZNF749,NRBP1,ZNF398,ZNF782,ZNF254,ZKSCAN4,ZNF597,ZNF311,ZNF764,ZNF619,ZNF530,ZNF552,ZNF136,ZNF420,ZNF775,NCOA6,ZKSCAN1,ZNF354B,ZNF726,ZNF226,UBE2D1,ZNF30,ZNF615,COX7C,ZNF649,ZNF556,COX11,MED16,ZNF175,TRIM28,YWHAG,COX20,CCNT2,ZNF641,ZNF697,G6PD,ZNF703,MAMLD1,WWTR1,ZNF253,ZNF778,ZNF441,NR3C2,ZNF786,ZNF445,ZNF584,ZNF771,ZNF264,ZNF691,ZNF205,LAMTOR5,SNW1,MED25,ZNF566,COX7B,UBB,ZNF710,MED1,ZNF484,ZNF184,TGIF1,KAT2A,UBC,ZNF180,ZFP30,TFDP1,ZFP69B,LRPPRC,ZNF573,ZNF224,YWHAH,ZNF547,ZNF12,TACO1,ZKSCAN8,RXRA,ZNF621,ZNF133,COX16,ZFP2,ZNF510,HKR1,ZNF3,ZNF567,COX18,TEAD2,CARM1,ZNF394,THRB,CHD9,ZNF14,PPARG,ZNF565,PRKAG1,YAP1,SESN1,ZNF627,RHEB,MED13,GLS,ZNF114,ZNF446,ZKSCAN3,E2F4,ZNF616,ZNF268,ZNF45,ZNF564,RRAGD,UBE2D3,LAMTOR3,MED31,ZNF41,COX4I1,DDIT4,ZNF432,MED10,MED8,TIGAR,ZNF440,ZFP69,ZNF74,ZNF692,MED7,MAML1,ZNF324,ZNF562,ZNF43,ZNF300,ZFP14,ZNF761,ESR2,ZNF611,ZNF717,NR2F1,RXRB,LAMTOR4,COX7A2L,YWHAZ,TBL1X,ZNF791,RARG,ZNF23,SFN,ZNF223,NR2C2AP,ZNF419,ZNF426,ZNF706,ZNF233,ZNF571,MTOR,ZNF546,E2F5,ZNF416,RRAGC,ZNF28,ZSCAN32,MED4,ZNF473,MED26,ZNF493,ZFP37,ZNF460,ZNF544,MAML3,ZNF599,RARA,ZNF529,AKT1,YWHAQ,ZNF10,ZNF138,ZNF707,SMAD3,ZNF700,ZNF333,ZNF18,ZNF701,SMAD4,ZNF600,CDKN2B,ZNF486,ZNF343,ZNF222,NR1H2,ZNF212,ZNF248,COX6A1,JUNB,ZNF860,ZNF785,ZNF839,SP1,ZNF563,TXNRD1,CDK8,NR3C1,GATA4,NR4A1,TEAD1,PPARA,ZNF324B,ZNF33A,ZNF554,SMURF2,MEN1,ZNF331,TRIM33,ZNF555,ZNF34,PPARD,ZNF77,ZNF286A,ZNF214,ZNF747,COX8A,RBPJ
R-HSA-162906	HIV Infection	3.63490223861362e-12	-26.3404388997714	221	135	0.0429116338207247	3146	8202	23511,2071,5720,404672,5696,5688,5701,8907,163,9972,6917,5901,6882,81929,7311,9978,8731,8905,5432,6827,291,5719,6233,5690,7251,27183,5705,5700,92421,6749,4836,5689,6884,5693,6872,5440,102157402,5713,3978,5715,11168,23165,129401,8178,5902,5062,51606,79902,5686,5438,5702,3981,6921,6875,55048,6829,5685,5691,9397,7520,5704,4331,2957,1104,160,5434,23636,5683,51510,5879,348995,5687,57122,10213,23198,25920,6881,6877,5441,6923,5436,5433,9525,5695,9631,25978,8021,6873,5903,905,7514,2534,5706,5709,9861,1175,5711,51497,9150,1173,6908,8480,5716,567,375,9491,9883,5478,3105,2962,5708,83860,2963,5717,2068,130340,7314,2959,3837,5694,5692,7936,5045,5905,55690,5710,7316,5430,7175,7852,22916,3159,6883,164,6878	NUP188,ERCC3,PSME1,GTF2H5,PSMB8,PSMA7,PSMC2,AP1M1,AP2B1,NUP153,TCEA1,RAN,TAF11,SEH1L,UBA52,RBX1,RNMT,AP1S2,POLR2C,SUPT4H1,SLC25A4,PSMD13,RPS27A,PSMB2,TSG101,VPS4A,PSMC5,PSMC1,CHMP4C,SSRP1,NMT1,PSMB1,TAF13,PSMB5,TAF1,POLR2K,AK6,PSMD7,LIG1,PSMD9,PSIP1,NUP205,NUP35,ELL,RANBP1,PAK2,ATP6V1H,NUP85,PSMA5,POLR2I,PSMC3,LIG4,TCEB1,TAF4B,VPS37C,SUPT5H,PSMA4,PSMB3,NMT2,XRCC5,PSMC4,MNAT1,GTF2A1,RCC1,AP2A1,POLR2E,NUP62,PSMA2,CHMP5,RAC1,NUP43,PSMA6,NUP107,PSMD14,PSME4,NELFB,TAF10,TAF5,POLR2L,TCEB2,POLR2G,POLR2D,VPS4B,PSMB7,NUP155,CHMP2B,NUP214,TAF2,RANBP2,CCNT2,XPO1,FYN,PSMC6,PSMD3,PSMD6,AP2S1,PSMD5,NELFCD,CTDP1,AP2M1,TBP,RAE1,PSMD10,B2M,ARF1,PSMF1,POM121,PPIA,HLA-A,GTF2F1,PSMD2,TAF3,GTF2F2,PSMD11,ERCC2,AP1S3,UBB,GTF2B,KPNB1,PSMB6,PSMB4,NELFE,FURIN,RANGAP1,PACS1,PSMD4,UBC,POLR2A,TPR,CXCR4,NCBP2,HMGA1,TAF12,AP1G1,TAF6
R-HSA-69306	DNA Replication	1.0382157603177e-11	-25.2909323982133	106	75	0.0238397965670693	3146	8202	5683,5720,1026,5424,5111,5687,890,5696,5688,51343,5701,10213,23198,1027,5984,7311,5983,1871,5695,990,5982,84296,5557,8318,5719,5706,6233,5709,84515,5690,5981,9861,5705,1870,5700,5711,4172,5689,55388,5693,4175,10926,5713,5716,3978,5715,9491,51053,5708,8317,1763,5717,7314,23595,5686,5694,9837,4999,5558,328,5692,5422,5702,5710,10714,5685,5691,7316,5704,5000,5427,5426,5001,5425,23594	PSMA2,PSME1,CDKN1A,POLD1,PCNA,PSMA6,CCNA2,PSMB8,PSMA7,FZR1,PSMC2,PSMD14,PSME4,CDKN1B,RFC4,UBA52,RFC3,E2F3,PSMB7,CDC6,RFC2,GINS4,PRIM1,CDC45,PSMD13,PSMC6,RPS27A,PSMD3,MCM8,PSMB2,RFC1,PSMD6,PSMC5,E2F2,PSMC1,PSMD5,MCM3,PSMB1,MCM10,PSMB5,MCM6,DBF4,PSMD7,PSMD10,LIG1,PSMD9,PSMF1,GMNN,PSMD2,CDC7,DNA2,PSMD11,UBB,ORC3,PSMA5,PSMB6,GINS1,ORC2,PRIM2,APEX1,PSMB4,POLA1,PSMC3,PSMD4,POLD3,PSMA4,PSMB3,UBC,PSMC4,ORC4,POLE2,POLE,ORC5,POLD2,ORC6
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	1.3306111313575e-11	-25.0427976889761	69	54	0.0171646535282899	3146	8202	51433,5689,5693,5683,9232,5713,5716,5720,5715,9491,64682,5708,5687,5696,5688,51343,5701,51529,10393,10213,23198,51434,5717,7321,7314,5686,5694,7311,5692,5702,991,6502,5695,29882,9212,8697,5710,5685,5691,7316,7324,5704,5719,996,5706,6233,5709,5690,6790,9861,5705,11065,5700,5711	ANAPC5,PSMB1,PSMB5,PSMA2,PTTG1,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,ANAPC1,PSMD2,PSMA6,PSMB8,PSMA7,FZR1,PSMC2,ANAPC11,ANAPC10,PSMD14,PSME4,ANAPC7,PSMD11,UBE2D1,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,SKP2,PSMB7,ANAPC2,AURKB,CDC23,PSMD4,PSMA4,PSMB3,UBC,UBE2E1,PSMC4,PSMD13,CDC27,PSMC6,RPS27A,PSMD3,PSMB2,AURKA,PSMD6,PSMC5,UBE2C,PSMC1,PSMD5
R-HSA-453276	Regulation of mitotic cell cycle	1.48909805957167e-11	-24.9302654154093	83	62	0.0197075651621106	3146	8202	51433,5689,5693,5683,9232,5713,8454,5716,5720,891,5715,9491,26271,64682,5708,5687,890,5696,5688,51343,5701,51529,10393,10213,23198,4751,51434,5717,7321,7314,5686,5694,7311,5692,5702,991,5695,6502,29882,9212,8697,5710,983,5685,5691,7316,7324,5704,5719,996,5706,6233,5709,4085,5690,6790,9861,5705,8556,11065,5700,5711	ANAPC5,PSMB1,PSMB5,PSMA2,PTTG1,PSMD7,CUL1,PSMD10,PSME1,CCNB1,PSMD9,PSMF1,FBXO5,ANAPC1,PSMD2,PSMA6,CCNA2,PSMB8,PSMA7,FZR1,PSMC2,ANAPC11,ANAPC10,PSMD14,PSME4,NEK2,ANAPC7,PSMD11,UBE2D1,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,SKP2,ANAPC2,AURKB,CDC23,PSMD4,CDK1,PSMA4,PSMB3,UBC,UBE2E1,PSMC4,PSMD13,CDC27,PSMC6,RPS27A,PSMD3,MAD2L1,PSMB2,AURKA,PSMD6,PSMC5,CDC14A,UBE2C,PSMC1,PSMD5
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	1.48909805957167e-11	-24.9302654154093	83	62	0.0197075651621106	3146	8202	51433,5689,5693,5683,9232,5713,8454,5716,5720,891,5715,9491,26271,64682,5708,5687,890,5696,5688,51343,5701,51529,10393,10213,23198,4751,51434,5717,7321,7314,5686,5694,7311,5692,5702,991,5695,6502,29882,9212,8697,5710,983,5685,5691,7316,7324,5704,5719,996,5706,6233,5709,4085,5690,6790,9861,5705,8556,11065,5700,5711	ANAPC5,PSMB1,PSMB5,PSMA2,PTTG1,PSMD7,CUL1,PSMD10,PSME1,CCNB1,PSMD9,PSMF1,FBXO5,ANAPC1,PSMD2,PSMA6,CCNA2,PSMB8,PSMA7,FZR1,PSMC2,ANAPC11,ANAPC10,PSMD14,PSME4,NEK2,ANAPC7,PSMD11,UBE2D1,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,SKP2,ANAPC2,AURKB,CDC23,PSMD4,CDK1,PSMA4,PSMB3,UBC,UBE2E1,PSMC4,PSMD13,CDC27,PSMC6,RPS27A,PSMD3,MAD2L1,PSMB2,AURKA,PSMD6,PSMC5,CDC14A,UBE2C,PSMC1,PSMD5
R-HSA-72172	mRNA Splicing	2.07609428029961e-11	-24.5979476442596	120	82	0.0260648442466624	3146	8202	9410,55599,65109,5356,10978,6636,6635,53981,5093,220988,83443,10992,3181,6427,29894,10286,84844,6429,3191,3192,5094,10291,23020,6629,5436,5441,5725,3185,5433,3183,10921,51585,11100,10907,10421,5432,55954,11051,10236,7307,8243,9128,2521,6637,6627,10594,51362,5440,10250,1660,10949,3187,10081,154007,2962,22826,56259,9343,2963,3184,4904,24148,4670,9295,5438,1479,51639,6430,8175,6626,5430,23450,9416,10181,5434,57819,1478,3190,22916,6428,6633,51503	SNRNP40,RNPC3,UPF3B,PLRG1,CLP1,SNRPF,SNRPE,CPSF2,PCBP1,HNRNPA3,SF3B5,SF3B2,HNRNPA2B1,SRSF2,CPSF1,BCAS2,PHF5A,SRSF4,HNRNPL,HNRNPU,PCBP2,SF3A1,SNRNP200,SNRPB2,POLR2G,POLR2L,PTBP1,HNRNPF,POLR2D,HNRNPC,RNPS1,PCF11,HNRNPUL1,TXNL4A,CD2BP2,POLR2C,ZMAT5,NUDT21,HNRNPR,U2AF1,SMC1A,PRPF4,FUS,SNRPG,SNRPA1,PRPF8,CDC40,POLR2K,SRRM1,DHX9,HNRNPA0,HNRNPH1,PDCD7,SNRNP48,GTF2F1,DNAJC8,CTNNBL1,EFTUD2,GTF2F2,HNRNPD,YBX1,PRPF6,HNRNPM,SRSF11,POLR2I,CSTF3,SF3B6,SRSF5,SF3A2,SNRPA,POLR2A,SF3B3,DDX23,RBM5,POLR2E,LSM2,CSTF2,HNRNPK,NCBP2,SRSF3,SNRPD2,CWC15
R-HSA-72163	mRNA Splicing - Major Pathway	2.93694308066967e-11	-24.2510667509979	113	78	0.0247933884297521	3146	8202	9410,65109,5356,10978,6636,6635,53981,5093,220988,83443,10992,3181,6427,29894,10286,84844,6429,3191,3192,5094,10291,23020,6629,5436,5441,5725,3185,5433,3183,10921,51585,11100,10907,10421,5432,11051,10236,7307,8243,9128,2521,6637,6627,10594,51362,5440,10250,1660,10949,3187,2962,22826,56259,9343,2963,3184,4904,24148,4670,9295,5438,1479,51639,6430,8175,6626,5430,9416,23450,10181,5434,57819,1478,3190,22916,6428,6633,51503	SNRNP40,UPF3B,PLRG1,CLP1,SNRPF,SNRPE,CPSF2,PCBP1,HNRNPA3,SF3B5,SF3B2,HNRNPA2B1,SRSF2,CPSF1,BCAS2,PHF5A,SRSF4,HNRNPL,HNRNPU,PCBP2,SF3A1,SNRNP200,SNRPB2,POLR2G,POLR2L,PTBP1,HNRNPF,POLR2D,HNRNPC,RNPS1,PCF11,HNRNPUL1,TXNL4A,CD2BP2,POLR2C,NUDT21,HNRNPR,U2AF1,SMC1A,PRPF4,FUS,SNRPG,SNRPA1,PRPF8,CDC40,POLR2K,SRRM1,DHX9,HNRNPA0,HNRNPH1,GTF2F1,DNAJC8,CTNNBL1,EFTUD2,GTF2F2,HNRNPD,YBX1,PRPF6,HNRNPM,SRSF11,POLR2I,CSTF3,SF3B6,SRSF5,SF3A2,SNRPA,POLR2A,DDX23,SF3B3,RBM5,POLR2E,LSM2,CSTF2,HNRNPK,NCBP2,SRSF3,SNRPD2,CWC15
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	4.46754019741492e-11	-23.831598057181	60	48	0.0152574698029243	3146	8202	51433,5689,5693,5683,5713,5716,5720,5715,9491,64682,5708,5687,5696,5688,51343,5701,51529,10393,10213,51434,5717,7321,7314,5686,5694,7311,5692,5702,5695,29882,8697,5710,5685,5691,7324,7316,5704,5719,996,5706,6233,5709,5690,9861,5705,11065,5700,5711	ANAPC5,PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,ANAPC1,PSMD2,PSMA6,PSMB8,PSMA7,FZR1,PSMC2,ANAPC11,ANAPC10,PSMD14,ANAPC7,PSMD11,UBE2D1,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,ANAPC2,CDC23,PSMD4,PSMA4,PSMB3,UBE2E1,UBC,PSMC4,PSMD13,CDC27,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,UBE2C,PSMC1,PSMD5
R-HSA-69242	S Phase	4.60223181225435e-11	-23.8018946605225	125	84	0.0267005721551176	3146	8202	5683,8454,157570,5720,1026,5424,898,7465,5111,5687,890,5696,5688,51343,5701,10213,23198,1027,5984,5983,7311,5695,10735,990,5982,84296,5557,8318,5719,6233,5706,5709,84515,8243,5690,5981,5705,9861,5700,5711,4172,5689,4175,5693,5713,3978,5716,5715,9491,5708,9126,1763,1163,5717,7314,23595,5686,5694,9837,993,4999,5692,5558,10274,328,5422,5702,6502,5710,10714,5685,5691,7316,5704,23244,4331,5000,5427,5426,23063,113130,5001,23594,5425	PSMA2,CUL1,ESCO2,PSME1,CDKN1A,POLD1,CCNE1,WEE1,PCNA,PSMA6,CCNA2,PSMB8,PSMA7,FZR1,PSMC2,PSMD14,PSME4,CDKN1B,RFC4,RFC3,UBA52,PSMB7,STAG2,CDC6,RFC2,GINS4,PRIM1,CDC45,PSMD13,RPS27A,PSMC6,PSMD3,MCM8,SMC1A,PSMB2,RFC1,PSMC5,PSMD6,PSMC1,PSMD5,MCM3,PSMB1,MCM6,PSMB5,PSMD7,LIG1,PSMD10,PSMD9,PSMF1,PSMD2,SMC3,DNA2,CKS1B,PSMD11,UBB,ORC3,PSMA5,PSMB6,GINS1,CDC25A,ORC2,PSMB4,PRIM2,STAG1,APEX1,POLA1,PSMC3,SKP2,PSMD4,POLD3,PSMA4,PSMB3,UBC,PSMC4,PDS5A,MNAT1,ORC4,POLE2,POLE,WAPL,CDCA5,ORC5,ORC6,POLD2
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	4.75499403670146e-11	-23.7692405810491	72	55	0.0174825174825175	3146	8202	51433,5689,5693,5683,9232,5713,5716,5720,891,5715,9491,64682,5708,5687,890,5696,5688,5701,51529,10393,10213,23198,4751,51434,5717,7321,7314,5686,5694,7311,5692,5702,991,5695,29882,8697,5710,983,5685,5691,7316,7324,5704,5719,996,5706,6233,5709,4085,5690,9861,5705,11065,5700,5711	ANAPC5,PSMB1,PSMB5,PSMA2,PTTG1,PSMD7,PSMD10,PSME1,CCNB1,PSMD9,PSMF1,ANAPC1,PSMD2,PSMA6,CCNA2,PSMB8,PSMA7,PSMC2,ANAPC11,ANAPC10,PSMD14,PSME4,NEK2,ANAPC7,PSMD11,UBE2D1,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,ANAPC2,CDC23,PSMD4,CDK1,PSMA4,PSMB3,UBC,UBE2E1,PSMC4,PSMD13,CDC27,PSMC6,RPS27A,PSMD3,MAD2L1,PSMB2,PSMD6,PSMC5,UBE2C,PSMC1,PSMD5
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	6.87219728181545e-11	-23.4009521306007	143	93	0.0295613477431659	3146	8202	51204,4712,8802,7381,29796,4191,6256,4711,9123,521,3418,4706,51079,51241,4709,9997,5164,1431,7385,2108,4714,8801,4715,4731,4700,4705,4720,285521,5160,4704,1350,4717,5163,9016,27089,3419,1353,514,1743,8050,116228,51660,515,6392,50,25915,27109,23530,4694,7388,6341,4713,4702,4729,1329,4719,6391,9481,682,4697,1327,506,374291,4724,137682,4723,4695,4710,1337,10476,10975,1349,55967,4696,3945,516,54704,51300,7384,5165,9551,5467,25874,518,509,728294,9167,10128,1351,6566,79133,498,3420	TACO1,NDUFB6,SUCLG1,UQCRB,UQCR10,MDH2,RXRA,NDUFB5,SLC16A3,ATP5I,IDH2,NDUFAB1,NDUFA13,COX16,NDUFB3,SCO2,PDK2,CS,UQCRC2,ETFA,NDUFB8,SUCLG2,NDUFB9,NDUFV3,NDUFA6,NDUFA10,NDUFS2,COX18,PDHA1,NDUFA9,COX7C,NDUFC1,PDK1,SLC25A14,UQCRQ,IDH3A,COX11,ATP5E,DLST,PDHX,COX20,MPC1,ATP5F1,SDHD,ACO2,NDUFAF3,ATP5S,NNT,NDUFA1,UQCRH,SCO1,NDUFB7,NDUFA8,NDUFV2,COX5B,NDUFS1,SDHC,SLC25A27,BSG,NDUFA4,COX4I1,ATP5B,NDUFS7,NDUFS4,NDUFAF6,NDUFV1,NDUFA2,NDUFB4,COX6A1,ATP5H,UQCR11,COX7B,NDUFA12,NDUFA3,LDHB,ATP5G1,PDP1,TIMMDC1,UQCRC1,PDK3,ATP5J2,PPARD,MPC2,ATP5G3,ATP5C1,D2HGDH,COX7A2L,LRPPRC,COX8A,SLC16A1,NDUFAF5,ATP5A1,IDH3B
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	8.67222251145155e-11	-23.168310919958	64	50	0.0158931977113795	3146	8202	51433,5689,5693,5683,9232,5713,5716,5720,5715,9491,64682,5708,5687,5696,5688,5701,51529,10393,10213,23198,51434,5717,7321,7314,5686,5694,7311,5692,5702,991,5695,29882,8697,5710,5685,5691,7316,7324,5704,5719,996,5706,6233,5709,5690,9861,5705,11065,5700,5711	ANAPC5,PSMB1,PSMB5,PSMA2,PTTG1,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,ANAPC1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,ANAPC11,ANAPC10,PSMD14,PSME4,ANAPC7,PSMD11,UBE2D1,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,ANAPC2,CDC23,PSMD4,PSMA4,PSMB3,UBC,UBE2E1,PSMC4,PSMD13,CDC27,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,UBE2C,PSMC1,PSMD5
R-HSA-69206	G1/S Transition	8.98961928307518e-11	-23.1323655242826	109	75	0.0238397965670693	3146	8202	5683,8454,5720,1026,891,898,5519,7465,5111,5687,890,5696,5688,5701,10213,1027,7311,5695,6241,990,9088,983,5557,8318,5719,6233,5706,5709,84515,7298,5690,9861,5705,5700,5711,4172,5689,55388,5693,4175,10926,5713,5716,5715,9491,7084,26271,5708,8317,1163,5717,7314,23595,5686,5694,993,4999,5692,5558,5422,5702,6502,5710,5685,5691,7316,5704,4331,5000,5427,5426,7027,5001,1719,23594	PSMA2,CUL1,PSME1,CDKN1A,CCNB1,CCNE1,PPP2R1B,WEE1,PCNA,PSMA6,CCNA2,PSMB8,PSMA7,PSMC2,PSMD14,CDKN1B,UBA52,PSMB7,RRM2,CDC6,PKMYT1,CDK1,PRIM1,CDC45,PSMD13,RPS27A,PSMC6,PSMD3,MCM8,TYMS,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5,MCM3,PSMB1,MCM10,PSMB5,MCM6,DBF4,PSMD7,PSMD10,PSMD9,PSMF1,TK2,FBXO5,PSMD2,CDC7,CKS1B,PSMD11,UBB,ORC3,PSMA5,PSMB6,CDC25A,ORC2,PSMB4,PRIM2,POLA1,PSMC3,SKP2,PSMD4,PSMA4,PSMB3,UBC,PSMC4,MNAT1,ORC4,POLE2,POLE,TFDP1,ORC5,DHFR,ORC6
R-HSA-69239	Synthesis of DNA	1.00536084738828e-10	-23.0205044007456	98	69	0.0219326128417038	3146	8202	5683,5720,1026,5424,5111,5687,890,5696,5688,51343,5701,10213,23198,1027,5984,7311,5983,5695,990,5982,84296,5557,8318,5719,5706,6233,5709,84515,5690,5981,9861,5705,5700,5711,4172,5689,5693,4175,5713,5716,3978,5715,9491,5708,1763,5717,7314,23595,5686,5694,9837,4999,5558,328,5692,5422,5702,5710,10714,5685,7316,5691,5704,5427,5426,5000,5001,5425,23594	PSMA2,PSME1,CDKN1A,POLD1,PCNA,PSMA6,CCNA2,PSMB8,PSMA7,FZR1,PSMC2,PSMD14,PSME4,CDKN1B,RFC4,UBA52,RFC3,PSMB7,CDC6,RFC2,GINS4,PRIM1,CDC45,PSMD13,PSMC6,RPS27A,PSMD3,MCM8,PSMB2,RFC1,PSMD6,PSMC5,PSMC1,PSMD5,MCM3,PSMB1,PSMB5,MCM6,PSMD7,PSMD10,LIG1,PSMD9,PSMF1,PSMD2,DNA2,PSMD11,UBB,ORC3,PSMA5,PSMB6,GINS1,ORC2,PRIM2,APEX1,PSMB4,POLA1,PSMC3,PSMD4,POLD3,PSMA4,UBC,PSMB3,PSMC4,POLE2,POLE,ORC4,ORC5,POLD2,ORC6
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	1.21113707939881e-10	-22.834291276566	73	55	0.0174825174825175	3146	8202	51433,5689,5693,5683,9232,5713,5716,5720,891,5715,9491,64682,5708,5687,890,5696,5688,5701,51529,10393,10213,23198,4751,51434,5717,7321,7314,5686,5694,7311,5692,5702,991,5695,29882,8697,5710,983,5685,5691,7316,7324,5704,5719,996,5706,6233,5709,4085,5690,9861,5705,11065,5700,5711	ANAPC5,PSMB1,PSMB5,PSMA2,PTTG1,PSMD7,PSMD10,PSME1,CCNB1,PSMD9,PSMF1,ANAPC1,PSMD2,PSMA6,CCNA2,PSMB8,PSMA7,PSMC2,ANAPC11,ANAPC10,PSMD14,PSME4,NEK2,ANAPC7,PSMD11,UBE2D1,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,ANAPC2,CDC23,PSMD4,CDK1,PSMA4,PSMB3,UBC,UBE2E1,PSMC4,PSMD13,CDC27,PSMC6,RPS27A,PSMD3,MAD2L1,PSMB2,PSMD6,PSMC5,UBE2C,PSMC1,PSMD5
R-HSA-4839726	Chromatin organization	1.66607980015212e-10	-22.515377488092	261	150	0.0476795931341386	3146	8202	3015,7403,55904,10524,8358,8350,9643,55170,440689,8365,1387,284058,8366,9070,8242,6605,6871,5926,8331,10498,8352,6595,7862,121536,51147,23133,55578,55193,23326,25855,8089,339287,1107,8473,3065,5253,60,3066,84661,102157402,3276,83933,9913,57492,80314,2122,6944,10419,8968,57459,8336,55929,9219,84159,55140,8841,6604,7468,51742,8289,8368,23338,55683,55818,51562,84289,54496,6907,9611,10856,112869,8354,6602,9869,2033,57504,196528,23512,6597,85235,54904,23028,64769,79595,83852,22992,8364,1108,4297,1386,8819,3054,84148,6881,26009,56943,79084,56950,53615,79960,8294,55250,23030,6599,8351,3014,10284,9575,8338,55689,8367,55729,8518,11091,8969,5929,8360,121504,2146,54815,55257,79723,23587,387893,653604,3717,54934,8345,8520,92815,10445,55167,5931,2648,5927,23186,6601,8357,8330,8464,3012,54859,8334,2874,23522,9757,10943,6883,6839,7994	H2AFZ,KDM6A,KMT2E,KAT5,HIST1H3B,HIST1H3A,MORF4L2,PRMT6,HIST2H2BF,HIST1H4H,CREBBP,KANSL1,HIST1H4B,ASH2L,KDM5C,SMARCE1,TADA2A,ARID4A,HIST1H2AJ,CARM1,HIST1H3C,SMARCA2,BRPF1,AEBP2,ING4,PHF8,SUPT20H,PBRM1,USP22,BRMS1,YEATS4,MSL1,CHD3,OGT,HDAC1,PHF2,ACTB,HDAC2,DPY30,AK6,PRMT1,HDAC10,SUPT7L,ARID1B,EPC1,MECOM,VPS72,PRMT5,HIST1H3F,GATAD2B,HIST1H2AM,DMAP1,MTA2,ARID5B,ELP3,HDAC3,SMARCD3,WHSC1,ARID4B,ARID1A,HIST1H4L,JADE2,KANSL3,KDM3A,MBIP,ING5,PRMT7,TBL1X,NCOR1,RUVBL2,SGF29,HIST1H3I,SMARCD1,SETDB1,EP300,MTA3,ARID2,SUZ12,SMARCA4,HIST1H2AH,WHSC1L1,KDM1A,MEAF6,SAP130,SETDB2,KDM2A,HIST1H4C,CHD4,KMT2A,ATF2,SAP30,HCFC1,KAT8,TAF10,ZZZ3,ENY2,WDR77,SMYD2,MBD3,JADE1,HIST1H4I,ELP2,KDM4B,SMARCC1,HIST1H3D,H2AFX,SAP18,CLOCK,HIST2H2AC,YEATS2,HIST1H4E,ATF7IP,IKBKAP,WDR5,HIST1H2AG,RBBP5,HIST1H4D,HIST4H4,EZH2,GATAD2A,MRGBP,SUV39H2,ELP5,KMT5A,HIST2H3D,JAK2,KANSL2,HIST1H2BH,HAT1,HIST3H2A,MCRS1,MSL2,RBBP7,KAT2A,KDM5A,RCOR1,SMARCC2,HIST1H3H,HIST1H2AK,SUPT3H,HIST1H2AE,ELP6,HIST1H2AC,GPS2,KAT6B,KMT2B,MSL3,TAF12,SUV39H1,KAT6A
R-HSA-3247509	Chromatin modifying enzymes	1.66607980015212e-10	-22.515377488092	261	150	0.0476795931341386	3146	8202	3015,7403,55904,10524,8358,8350,9643,55170,440689,8365,1387,284058,8366,9070,8242,6605,6871,5926,8331,10498,8352,6595,7862,121536,51147,23133,55578,55193,23326,25855,8089,339287,1107,8473,3065,5253,60,3066,84661,102157402,3276,83933,9913,57492,80314,2122,6944,10419,8968,57459,8336,55929,9219,84159,55140,8841,6604,7468,51742,8289,8368,23338,55683,55818,51562,84289,54496,6907,9611,10856,112869,8354,6602,9869,2033,57504,196528,23512,6597,85235,54904,23028,64769,79595,83852,22992,8364,1108,4297,1386,8819,3054,84148,6881,26009,56943,79084,56950,53615,79960,8294,55250,23030,6599,8351,3014,10284,9575,8338,55689,8367,55729,8518,11091,8969,5929,8360,121504,2146,54815,55257,79723,23587,387893,653604,3717,54934,8345,8520,92815,10445,55167,5931,2648,5927,23186,6601,8357,8330,8464,3012,54859,8334,2874,23522,9757,10943,6883,6839,7994	H2AFZ,KDM6A,KMT2E,KAT5,HIST1H3B,HIST1H3A,MORF4L2,PRMT6,HIST2H2BF,HIST1H4H,CREBBP,KANSL1,HIST1H4B,ASH2L,KDM5C,SMARCE1,TADA2A,ARID4A,HIST1H2AJ,CARM1,HIST1H3C,SMARCA2,BRPF1,AEBP2,ING4,PHF8,SUPT20H,PBRM1,USP22,BRMS1,YEATS4,MSL1,CHD3,OGT,HDAC1,PHF2,ACTB,HDAC2,DPY30,AK6,PRMT1,HDAC10,SUPT7L,ARID1B,EPC1,MECOM,VPS72,PRMT5,HIST1H3F,GATAD2B,HIST1H2AM,DMAP1,MTA2,ARID5B,ELP3,HDAC3,SMARCD3,WHSC1,ARID4B,ARID1A,HIST1H4L,JADE2,KANSL3,KDM3A,MBIP,ING5,PRMT7,TBL1X,NCOR1,RUVBL2,SGF29,HIST1H3I,SMARCD1,SETDB1,EP300,MTA3,ARID2,SUZ12,SMARCA4,HIST1H2AH,WHSC1L1,KDM1A,MEAF6,SAP130,SETDB2,KDM2A,HIST1H4C,CHD4,KMT2A,ATF2,SAP30,HCFC1,KAT8,TAF10,ZZZ3,ENY2,WDR77,SMYD2,MBD3,JADE1,HIST1H4I,ELP2,KDM4B,SMARCC1,HIST1H3D,H2AFX,SAP18,CLOCK,HIST2H2AC,YEATS2,HIST1H4E,ATF7IP,IKBKAP,WDR5,HIST1H2AG,RBBP5,HIST1H4D,HIST4H4,EZH2,GATAD2A,MRGBP,SUV39H2,ELP5,KMT5A,HIST2H3D,JAK2,KANSL2,HIST1H2BH,HAT1,HIST3H2A,MCRS1,MSL2,RBBP7,KAT2A,KDM5A,RCOR1,SMARCC2,HIST1H3H,HIST1H2AK,SUPT3H,HIST1H2AE,ELP6,HIST1H2AC,GPS2,KAT6B,KMT2B,MSL3,TAF12,SUV39H1,KAT6A
R-HSA-4608870	Asymmetric localization of PCP proteins	1.78757438987182e-10	-22.4449913185089	63	49	0.0155753337571519	3146	8202	5689,5693,5683,8325,5713,5716,5720,2535,5715,9491,7474,5708,5687,5696,5688,5701,10213,23198,5717,7314,1856,5686,5694,8321,7311,5692,8322,7976,5702,5695,23513,64750,5710,5685,5691,7316,8324,5704,5719,5706,6233,5709,5690,7855,9861,5705,57154,5700,5711	PSMB1,PSMB5,PSMA2,FZD8,PSMD7,PSMD10,PSME1,FZD2,PSMD9,PSMF1,WNT5A,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,DVL2,PSMA5,PSMB6,FZD1,UBA52,PSMB4,FZD4,FZD3,PSMC3,PSMB7,SCRIB,SMURF2,PSMD4,PSMA4,PSMB3,UBC,FZD7,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,FZD5,PSMD6,PSMC5,SMURF1,PSMC1,PSMD5
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	1.92590431821914e-10	-22.3704552968125	70	53	0.0168467895740623	3146	8202	51433,5689,5693,5683,5713,5716,5720,5715,9491,64682,5708,5687,890,5696,5688,5701,51529,10393,10213,23198,4751,51434,5717,7321,7314,5686,5694,7311,5692,5702,991,5695,29882,8697,5710,983,5685,5691,7316,7324,5704,5719,996,5706,6233,5709,4085,5690,9861,5705,11065,5700,5711	ANAPC5,PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,ANAPC1,PSMD2,PSMA6,CCNA2,PSMB8,PSMA7,PSMC2,ANAPC11,ANAPC10,PSMD14,PSME4,NEK2,ANAPC7,PSMD11,UBE2D1,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,ANAPC2,CDC23,PSMD4,CDK1,PSMA4,PSMB3,UBC,UBE2E1,PSMC4,PSMD13,CDC27,PSMC6,RPS27A,PSMD3,MAD2L1,PSMB2,PSMD6,PSMC5,UBE2C,PSMC1,PSMD5
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	3.84992340002401e-10	-21.6777976779364	69	52	0.0165289256198347	3146	8202	51433,5689,5693,5683,5713,5716,5720,5715,9491,64682,5708,5687,890,5696,5688,5701,51529,10393,10213,23198,51434,5717,7321,7314,5686,5694,7311,5692,5702,991,5695,29882,8697,5710,983,5685,5691,7316,7324,5704,5719,996,5706,6233,5709,4085,5690,9861,5705,11065,5700,5711	ANAPC5,PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,ANAPC1,PSMD2,PSMA6,CCNA2,PSMB8,PSMA7,PSMC2,ANAPC11,ANAPC10,PSMD14,PSME4,ANAPC7,PSMD11,UBE2D1,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,ANAPC2,CDC23,PSMD4,CDK1,PSMA4,PSMB3,UBC,UBE2E1,PSMC4,PSMD13,CDC27,PSMC6,RPS27A,PSMD3,MAD2L1,PSMB2,PSMD6,PSMC5,UBE2C,PSMC1,PSMD5
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	8.25751668275434e-10	-20.9147270313443	77	56	0.0178003814367451	3146	8202	51433,5689,5693,5683,5713,8454,5716,5720,891,5715,9491,26271,64682,5708,5687,890,5696,5688,51343,5701,51529,10393,10213,23198,51434,5717,7321,7314,5686,5694,7311,5692,5702,991,5695,29882,8697,5710,983,5685,5691,7316,7324,5704,5719,996,5706,6233,5709,4085,5690,9861,5705,11065,5700,5711	ANAPC5,PSMB1,PSMB5,PSMA2,PSMD7,CUL1,PSMD10,PSME1,CCNB1,PSMD9,PSMF1,FBXO5,ANAPC1,PSMD2,PSMA6,CCNA2,PSMB8,PSMA7,FZR1,PSMC2,ANAPC11,ANAPC10,PSMD14,PSME4,ANAPC7,PSMD11,UBE2D1,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,ANAPC2,CDC23,PSMD4,CDK1,PSMA4,PSMB3,UBC,UBE2E1,PSMC4,PSMD13,CDC27,PSMC6,RPS27A,PSMD3,MAD2L1,PSMB2,PSMD6,PSMC5,UBE2C,PSMC1,PSMD5
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	8.61954130839579e-10	-20.8718190591638	56	44	0.013986013986014	3146	8202	6224,6202,6209,6187,1964,6235,6193,3646,6218,6217,6234,6205,6194,6227,8665,6222,1977,26986,6228,6207,6230,8669,1974,6204,6232,7458,6203,8666,8667,3921,8661,6189,27335,1981,6210,1968,6233,1978,6208,1965,6206,6188,8662,6231	RPS20,RPS8,RPS15,RPS2,EIF1AX,RPS29,RPS5,EIF3E,RPS17,RPS16,RPS28,RPS11,RPS6,RPS21,EIF3F,RPS18,EIF4E,PABPC1,RPS23,RPS13,RPS25,EIF3J,EIF4A2,RPS10,RPS27,EIF4H,RPS9,EIF3G,EIF3H,RPSA,EIF3A,RPS3A,EIF3K,EIF4G1,RPS15A,EIF2S3,RPS27A,EIF4EBP1,RPS14,EIF2S1,RPS12,RPS3,EIF3B,RPS26
R-HSA-68827	CDT1 association with the CDC6:ORC:origin complex	1.1619875887643e-09	-20.5731338594995	58	45	0.0143038779402416	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,51053,5708,5687,5696,5688,5701,10213,23198,5717,23595,7314,5686,5694,4999,7311,5692,5702,5695,990,5710,5685,5691,7316,5704,5000,5719,5706,6233,5709,5001,84515,5690,9861,5705,5700,5711,23594	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,GMNN,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,PSMC3,PSMB7,CDC6,PSMD4,PSMA4,PSMB3,UBC,PSMC4,ORC4,PSMD13,PSMC6,RPS27A,PSMD3,ORC5,MCM8,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5,ORC6
R-HSA-72702	Ribosomal scanning and start codon recognition	1.78581712372759e-09	-20.1433897540642	55	43	0.0136681500317864	3146	8202	6224,6202,6209,6187,1964,6235,6193,3646,6218,6217,6234,6205,6194,6227,8665,6222,1983,1977,6228,6207,6230,8669,1974,6204,6232,7458,6203,8666,8667,3921,8661,6189,27335,1981,6210,1968,6233,6208,1965,6206,6188,8662,6231	RPS20,RPS8,RPS15,RPS2,EIF1AX,RPS29,RPS5,EIF3E,RPS17,RPS16,RPS28,RPS11,RPS6,RPS21,EIF3F,RPS18,EIF5,EIF4E,RPS23,RPS13,RPS25,EIF3J,EIF4A2,RPS10,RPS27,EIF4H,RPS9,EIF3G,EIF3H,RPSA,EIF3A,RPS3A,EIF3K,EIF4G1,RPS15A,EIF2S3,RPS27A,RPS14,EIF2S1,RPS12,RPS3,EIF3B,RPS26
R-HSA-72649	Translation initiation complex formation	1.78581712372759e-09	-20.1433897540642	55	43	0.0136681500317864	3146	8202	6224,6202,6209,6187,1964,6235,6193,3646,6218,6217,6234,6205,6194,6227,8665,6222,1977,26986,6228,6207,6230,8669,1974,6204,6232,7458,6203,8666,8667,3921,8661,6189,27335,1981,6210,1968,6233,6208,1965,6206,6188,8662,6231	RPS20,RPS8,RPS15,RPS2,EIF1AX,RPS29,RPS5,EIF3E,RPS17,RPS16,RPS28,RPS11,RPS6,RPS21,EIF3F,RPS18,EIF4E,PABPC1,RPS23,RPS13,RPS25,EIF3J,EIF4A2,RPS10,RPS27,EIF4H,RPS9,EIF3G,EIF3H,RPSA,EIF3A,RPS3A,EIF3K,EIF4G1,RPS15A,EIF2S3,RPS27A,RPS14,EIF2S1,RPS12,RPS3,EIF3B,RPS26
R-HSA-68874	M/G1 Transition	2.38926406136595e-09	-19.852280442536	82	58	0.0184361093452003	3146	8202	5689,4175,5693,55388,5683,10926,5713,5716,5720,5715,9491,51053,5708,5687,5696,8317,5688,5701,10213,23198,5717,23595,7314,5686,5694,4999,7311,5692,5558,5422,5702,1871,5695,990,5710,5685,5691,7316,5704,5557,8318,5000,5426,5719,5427,5706,6233,5709,5001,84515,5690,9861,5705,1870,5700,5711,23594,4172	PSMB1,MCM6,PSMB5,MCM10,PSMA2,DBF4,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,GMNN,PSMD2,PSMA6,PSMB8,CDC7,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,PRIM2,POLA1,PSMC3,E2F3,PSMB7,CDC6,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PRIM1,CDC45,ORC4,POLE,PSMD13,POLE2,PSMC6,RPS27A,PSMD3,ORC5,MCM8,PSMB2,PSMD6,PSMC5,E2F2,PSMC1,PSMD5,ORC6,MCM3
R-HSA-69002	DNA Replication Pre-Initiation	2.38926406136595e-09	-19.852280442536	82	58	0.0184361093452003	3146	8202	5689,4175,5693,55388,5683,10926,5713,5716,5720,5715,9491,51053,5708,5687,5696,8317,5688,5701,10213,23198,5717,23595,7314,5686,5694,4999,7311,5692,5558,5422,5702,1871,5695,990,5710,5685,5691,7316,5704,5557,8318,5000,5426,5719,5427,5706,6233,5709,5001,84515,5690,9861,5705,1870,5700,5711,23594,4172	PSMB1,MCM6,PSMB5,MCM10,PSMA2,DBF4,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,GMNN,PSMD2,PSMA6,PSMB8,CDC7,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,PRIM2,POLA1,PSMC3,E2F3,PSMB7,CDC6,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PRIM1,CDC45,ORC4,POLE,PSMD13,POLE2,PSMC6,RPS27A,PSMD3,ORC5,MCM8,PSMB2,PSMD6,PSMC5,E2F2,PSMC1,PSMD5,ORC6,MCM3
R-HSA-5368286	Mitochondrial translation initiation	2.68296319757119e-09	-19.7363439824918	84	59	0.0187539732994278	3146	8202	51373,65080,28977,54148,124995,64949,3396,51263,29093,9801,64963,10884,56945,54534,10240,740,23107,55037,6183,116541,51023,64975,64976,219927,29088,64951,51253,51650,51258,4528,84545,6182,90480,55173,219402,60488,122704,64928,63931,64979,51318,51081,55052,54460,10573,51069,7818,128308,64978,123263,51649,64432,118487,9553,51264,28957,51021,11222,54998	MRPS17,MRPL44,MRPL42,MRPL39,MRPL10,MRPS26,ICT1,MRPL30,MRPL22,MRPL19,MRPS11,MRPS30,MRPS22,MRPL50,MRPS31,MRPL49,MRPS27,PTCD3,MRPS12,MRPL54,MRPS18C,MRPL41,MRPL40,MRPL21,MRPL15,MRPS24,MRPL37,MRPS33,MRPL51,MTIF2,MRPL43,MRPL12,GADD45GIP1,MRPS10,MTIF3,MRPS35,MRPL52,MRPL14,MRPS14,MRPL36,MRPL35,MRPS7,MRPL20,MRPS21,MRPL28,MRPL2,DAP3,MRPL55,MRPL38,MTFMT,MRPS23,MRPS25,CHCHD1,MRPL33,MRPL27,MRPS28,MRPS16,MRPL3,AURKAIP1
R-HSA-69304	Regulation of DNA replication	3.03424888660535e-09	-19.6133019268844	75	54	0.0171646535282899	3146	8202	5689,4175,5693,55388,5683,5713,5716,5720,1026,5715,9491,51053,5708,5687,890,5696,5688,51343,5701,10213,23198,1027,5717,23595,7314,5686,5694,4999,7311,5692,5702,5695,1871,990,5710,5685,5691,7316,5704,5000,5719,5706,6233,5709,5001,84515,5690,9861,5705,1870,5700,5711,23594,4172	PSMB1,MCM6,PSMB5,MCM10,PSMA2,PSMD7,PSMD10,PSME1,CDKN1A,PSMD9,PSMF1,GMNN,PSMD2,PSMA6,CCNA2,PSMB8,PSMA7,FZR1,PSMC2,PSMD14,PSME4,CDKN1B,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,PSMC3,PSMB7,E2F3,CDC6,PSMD4,PSMA4,PSMB3,UBC,PSMC4,ORC4,PSMD13,PSMC6,RPS27A,PSMD3,ORC5,MCM8,PSMB2,PSMD6,PSMC5,E2F2,PSMC1,PSMD5,ORC6,MCM3
R-HSA-5368287	Mitochondrial translation	3.61050148523248e-09	-19.4394191586726	90	62	0.0197075651621106	3146	8202	51373,65080,28977,54148,10102,124995,64949,3396,51263,29093,84340,9801,64963,10884,56945,54534,10240,740,23107,55037,6183,116541,51023,64975,64976,219927,29088,64951,51253,51650,51258,4528,84545,6182,7284,90480,55173,219402,60488,122704,64928,63931,55052,64979,51318,51081,54460,10573,51069,7818,128308,123263,64978,51649,64432,118487,9553,51264,28957,51021,11222,54998	MRPS17,MRPL44,MRPL42,MRPL39,TSFM,MRPL10,MRPS26,ICT1,MRPL30,MRPL22,GFM2,MRPL19,MRPS11,MRPS30,MRPS22,MRPL50,MRPS31,MRPL49,MRPS27,PTCD3,MRPS12,MRPL54,MRPS18C,MRPL41,MRPL40,MRPL21,MRPL15,MRPS24,MRPL37,MRPS33,MRPL51,MTIF2,MRPL43,MRPL12,TUFM,GADD45GIP1,MRPS10,MTIF3,MRPS35,MRPL52,MRPL14,MRPS14,MRPL20,MRPL36,MRPL35,MRPS7,MRPS21,MRPL28,MRPL2,DAP3,MRPL55,MTFMT,MRPL38,MRPS23,MRPS25,CHCHD1,MRPL33,MRPL27,MRPS28,MRPS16,MRPL3,AURKAIP1
R-HSA-162909	Host Interactions of HIV factors	4.62612522471741e-09	-19.1915462037419	127	81	0.0257469802924348	3146	8202	23511,5683,5879,5720,348995,5696,5687,5688,5701,23198,8907,57122,10213,163,9972,5901,81929,7311,6923,9978,8905,5695,9631,8021,5903,2534,7514,291,5719,5706,6233,5709,5690,9861,5705,5700,1175,5711,5689,1173,5693,8480,5713,5716,567,375,5715,9491,11168,23165,9883,129401,5478,3105,5708,5902,5062,5717,130340,7314,51606,79902,5686,3837,5694,5692,5702,6921,5905,55690,5710,5685,7316,5691,5704,7175,1104,160,23636,3159,164	NUP188,PSMA2,RAC1,PSME1,NUP43,PSMB8,PSMA6,PSMA7,PSMC2,PSME4,AP1M1,NUP107,PSMD14,AP2B1,NUP153,RAN,SEH1L,UBA52,TCEB2,RBX1,AP1S2,PSMB7,NUP155,NUP214,RANBP2,FYN,XPO1,SLC25A4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,AP2S1,PSMD5,PSMB1,AP2M1,PSMB5,RAE1,PSMD7,PSMD10,B2M,ARF1,PSMD9,PSMF1,PSIP1,NUP205,POM121,NUP35,PPIA,HLA-A,PSMD2,RANBP1,PAK2,PSMD11,AP1S3,UBB,ATP6V1H,NUP85,PSMA5,KPNB1,PSMB6,PSMB4,PSMC3,TCEB1,RANGAP1,PACS1,PSMD4,PSMA4,UBC,PSMB3,PSMC4,TPR,RCC1,AP2A1,NUP62,HMGA1,AP1G1
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	4.84167163872479e-09	-19.146005795946	56	43	0.0136681500317864	3146	8202	5689,5693,5683,5713,8454,5716,5720,1026,5715,9491,898,5708,5687,890,5696,5688,5701,10213,1163,1027,5717,7314,5686,5694,7311,5692,5702,6502,5695,5710,5685,5691,7316,5704,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,CUL1,PSMD10,PSME1,CDKN1A,PSMD9,PSMF1,CCNE1,PSMD2,PSMA6,CCNA2,PSMB8,PSMA7,PSMC2,PSMD14,CKS1B,CDKN1B,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,SKP2,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-69300	Removal of licensing factors from origins	4.9994651424205e-09	-19.1139349017501	72	52	0.0165289256198347	3146	8202	5689,4175,5693,55388,5683,5713,5716,5720,1026,5715,9491,51053,5708,5687,890,5696,5688,51343,5701,10213,23198,1027,5717,23595,7314,5686,5694,4999,7311,5692,5702,5695,990,5710,5685,5691,7316,5704,5000,5719,5706,6233,5709,5001,84515,5690,9861,5705,5700,5711,23594,4172	PSMB1,MCM6,PSMB5,MCM10,PSMA2,PSMD7,PSMD10,PSME1,CDKN1A,PSMD9,PSMF1,GMNN,PSMD2,PSMA6,CCNA2,PSMB8,PSMA7,FZR1,PSMC2,PSMD14,PSME4,CDKN1B,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,PSMC3,PSMB7,CDC6,PSMD4,PSMA4,PSMB3,UBC,PSMC4,ORC4,PSMD13,PSMC6,RPS27A,PSMD3,ORC5,MCM8,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5,ORC6,MCM3
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	5.45930250510775e-09	-19.0259448016671	102	68	0.0216147488874762	3146	8202	51204,4712,7381,29796,4711,521,4706,51079,51241,4709,9997,2108,4714,7385,4715,4731,4700,4705,4720,285521,4704,1350,4717,9016,27089,1353,514,116228,515,6392,25915,27109,4694,7388,6341,4702,4713,4729,1329,4719,6391,9481,1327,4697,506,374291,4724,137682,4723,4695,4710,10476,1337,10975,1349,55967,4696,516,51300,7384,9551,518,509,9167,1351,10128,79133,498	TACO1,NDUFB6,UQCRB,UQCR10,NDUFB5,ATP5I,NDUFAB1,NDUFA13,COX16,NDUFB3,SCO2,ETFA,NDUFB8,UQCRC2,NDUFB9,NDUFV3,NDUFA6,NDUFA10,NDUFS2,COX18,NDUFA9,COX7C,NDUFC1,SLC25A14,UQCRQ,COX11,ATP5E,COX20,ATP5F1,SDHD,NDUFAF3,ATP5S,NDUFA1,UQCRH,SCO1,NDUFA8,NDUFB7,NDUFV2,COX5B,NDUFS1,SDHC,SLC25A27,COX4I1,NDUFA4,ATP5B,NDUFS7,NDUFS4,NDUFAF6,NDUFV1,NDUFA2,NDUFB4,ATP5H,COX6A1,UQCR11,COX7B,NDUFA12,NDUFA3,ATP5G1,TIMMDC1,UQCRC1,ATP5J2,ATP5G3,ATP5C1,COX7A2L,COX8A,LRPPRC,NDUFAF5,ATP5A1
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	6.0428723182793e-09	-18.9243863886535	87	60	0.0190718372536554	3146	8202	5689,5693,51010,5683,5713,5716,5720,5715,5073,9491,3303,5708,5687,23016,5696,5688,5701,56915,10213,23198,3184,8125,5717,54512,7314,26986,5686,5694,23404,7311,118460,5692,207,5702,5695,5393,5710,8021,5685,5691,7316,3304,5704,1981,7514,5719,1994,6233,5706,5709,6418,8570,5690,7534,54464,5705,9861,5700,5711,3842	PSMB1,PSMB5,EXOSC3,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PARN,PSMF1,HSPA1A,PSMD2,PSMA6,EXOSC7,PSMB8,PSMA7,PSMC2,EXOSC5,PSMD14,PSME4,HNRNPD,ANP32A,PSMD11,EXOSC4,UBB,PABPC1,PSMA5,PSMB6,EXOSC2,UBA52,EXOSC6,PSMB4,AKT1,PSMC3,PSMB7,EXOSC9,PSMD4,NUP214,PSMA4,PSMB3,UBC,HSPA1B,PSMC4,EIF4G1,XPO1,PSMD13,ELAVL1,RPS27A,PSMC6,PSMD3,SET,KHSRP,PSMB2,YWHAZ,XRN1,PSMC5,PSMD6,PSMC1,PSMD5,TNPO1
R-HSA-68867	Assembly of the pre-replicative complex	6.9949339042935e-09	-18.7780796778667	67	49	0.0155753337571519	3146	8202	5689,4175,5693,5683,5713,5716,5720,5715,9491,51053,5708,5687,5696,5688,5701,10213,23198,5717,23595,7314,5686,5694,4999,7311,5692,5702,5695,1871,990,5710,5685,5691,7316,5704,5000,5719,5706,6233,5709,5001,84515,5690,9861,5705,1870,5700,5711,23594,4172	PSMB1,MCM6,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,GMNN,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,PSMC3,PSMB7,E2F3,CDC6,PSMD4,PSMA4,PSMB3,UBC,PSMC4,ORC4,PSMD13,PSMC6,RPS27A,PSMD3,ORC5,MCM8,PSMB2,PSMD6,PSMC5,E2F2,PSMC1,PSMD5,ORC6,MCM3
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	8.54650400751977e-09	-18.5777435256246	48	38	0.0120788302606484	3146	8202	6224,6202,6209,6187,1964,6235,6193,3646,6218,6217,6234,6205,6194,6227,8665,6222,6228,6207,6230,8669,6204,6232,6203,8666,8667,3921,8661,6189,27335,6210,1968,6233,6208,1965,6206,6188,8662,6231	RPS20,RPS8,RPS15,RPS2,EIF1AX,RPS29,RPS5,EIF3E,RPS17,RPS16,RPS28,RPS11,RPS6,RPS21,EIF3F,RPS18,RPS23,RPS13,RPS25,EIF3J,RPS10,RPS27,RPS9,EIF3G,EIF3H,RPSA,EIF3A,RPS3A,EIF3K,RPS15A,EIF2S3,RPS27A,RPS14,EIF2S1,RPS12,RPS3,EIF3B,RPS26
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	9.8064507363717e-09	-18.4402254294085	55	42	0.0133502860775588	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,3303,5708,5687,5696,5688,5701,10213,23198,3184,5717,7314,26986,5686,5694,7311,5692,5702,5695,5710,5685,5691,7316,3304,5704,1981,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,HSPA1A,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,HNRNPD,PSMD11,UBB,PABPC1,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,HSPA1B,PSMC4,EIF4G1,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-5389840	Mitochondrial translation elongation	1.01127709592443e-08	-18.4094667604343	84	58	0.0184361093452003	3146	8202	51373,65080,28977,54148,10102,124995,64949,3396,51263,29093,9801,64963,10884,56945,54534,10240,740,23107,55037,6183,116541,51023,64975,64976,219927,29088,64951,51253,51650,51258,84545,6182,7284,90480,55173,60488,122704,64928,63931,64979,51318,51081,55052,54460,10573,51069,7818,128308,64978,51649,64432,118487,9553,51264,28957,51021,11222,54998	MRPS17,MRPL44,MRPL42,MRPL39,TSFM,MRPL10,MRPS26,ICT1,MRPL30,MRPL22,MRPL19,MRPS11,MRPS30,MRPS22,MRPL50,MRPS31,MRPL49,MRPS27,PTCD3,MRPS12,MRPL54,MRPS18C,MRPL41,MRPL40,MRPL21,MRPL15,MRPS24,MRPL37,MRPS33,MRPL51,MRPL43,MRPL12,TUFM,GADD45GIP1,MRPS10,MRPS35,MRPL52,MRPL14,MRPS14,MRPL36,MRPL35,MRPS7,MRPL20,MRPS21,MRPL28,MRPL2,DAP3,MRPL55,MRPL38,MRPS23,MRPS25,CHCHD1,MRPL33,MRPL27,MRPS28,MRPS16,MRPL3,AURKAIP1
R-HSA-169911	Regulation of Apoptosis	1.16684278842958e-08	-18.2663791140076	50	39	0.012396694214876	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,5708,5687,5696,5688,5062,5701,10213,23198,5717,7314,5686,5694,7311,5692,5702,5695,5710,5685,5691,7316,5704,5719,5706,6233,5709,5690,9861,5705,5700,79658,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PAK2,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,ARHGAP10,PSMD5
R-HSA-2262752	Cellular responses to stress	1.35871485922284e-08	-18.114141447411	379	198	0.0629370629370629	3146	8202	3015,23511,7249,9588,2034,60673,5565,10524,8358,8350,1026,7531,10013,81631,8678,898,5606,55626,8365,57521,1031,1387,64682,6196,11337,8366,5034,51343,51529,26277,10393,4361,9972,1021,10587,8331,81929,11152,64223,8352,7311,9978,8550,23466,57805,9140,5571,7422,6009,3305,6233,3009,10325,2932,25828,1870,92421,58528,7323,51433,10808,5562,30849,8649,8408,3008,3337,9532,9973,493869,23165,129401,51182,5601,5598,79902,25842,8968,22863,7867,9821,30001,6921,8368,7324,847,51422,996,2114,3091,389541,23636,23523,26100,4217,23192,6416,6197,192669,1029,8354,2033,5599,538,3397,2475,8655,23512,6648,3297,64121,348995,3303,6015,3490,54386,4193,890,65057,10049,8364,57122,84733,1027,51434,7321,112399,5970,1032,84971,9529,23411,6923,3326,1871,9631,8697,25978,8021,8294,5903,817,3308,112398,8351,3014,9474,22824,8338,3020,5594,4343,8535,573,1030,23112,23043,7405,8367,8480,2113,1915,8360,9883,2146,121504,10542,84938,653604,6782,3320,8345,10728,7314,6774,6667,7296,5931,5609,22955,29882,8357,318,7316,3304,5595,7175,3012,8334,3569,5608,7027,8453,7322,3159,11065,7013,2876	H2AFZ,NUP188,TSC2,PRDX6,EPAS1,ATG101,PRKAB2,KAT5,HIST1H3B,HIST1H3A,CDKN1A,YWHAE,HDAC6,MAP1LC3B,BECN1,CCNE1,MAP2K3,AMBRA1,HIST1H4H,RPTOR,CDKN2C,CREBBP,ANAPC1,RPS6KA2,GABARAP,HIST1H4B,P4HB,FZR1,ANAPC11,TINF2,ANAPC10,MRE11A,NUP153,CDK6,TXNRD2,HIST1H2AJ,SEH1L,WDR45,MLST8,HIST1H3C,UBA52,RBX1,MAPKAPK5,CBX6,CCAR2,ATG12,PRKAG1,VEGFA,RHEB,HSPA1L,RPS27A,HIST1H1B,RRAGB,GSK3B,TXN2,E2F2,CHMP4C,RRAGD,UBE2D3,ANAPC5,HSPH1,PRKAA1,PIK3R4,LAMTOR3,ULK1,HIST1H1E,DNAJB1,BAG2,CCS,GPX8,NUP205,NUP35,HSPA14,MAPK9,MAPK7,NUP85,ASF1A,HIST1H3F,ATG14,MAPKAPK3,RB1CC1,ERO1A,TCEB1,HIST1H4L,UBE2E1,CAT,PRKAG2,CDC27,ETS2,HIF1A,LAMTOR4,NUP62,CABIN1,WIPI2,MAP3K5,ATG4B,MAP2K4,RPS6KA3,AGO3,CDKN2A,HIST1H3I,EP300,MAPK8,ATP7A,ID1,MTOR,DYNLL1,SUZ12,SOD2,HSF1,RRAGC,NUP43,HSPA1A,RING1,IGFBP7,TERF2IP,MDM2,CCNA2,ACD,DNAJB6,HIST1H4C,NUP107,CBX2,CDKN1B,ANAPC7,UBE2D1,EGLN3,RELA,CDKN2D,ATG4D,BAG5,SIRT1,TCEB2,HSP90AB1,E2F3,NUP155,CDC23,CHMP2B,NUP214,HIST1H4I,RANBP2,CAMK2D,HSPA4,EGLN2,HIST1H3D,H2AFX,ATG5,HSPA4L,HIST2H2AC,H3F3A,MAPK1,MOV10,CBX4,BAG1,CDKN2B,TNRC6B,TNIK,UVRAG,HIST1H4E,RAE1,ETS1,EEF1A1,HIST1H4D,POM121,EZH2,HIST4H4,LAMTOR5,ATG4C,HIST2H3D,HSPA13,HSP90AA1,HIST1H2BH,PTGES3,UBB,STAT3,SP1,TXNRD1,RBBP7,MAP2K7,SCMH1,ANAPC2,HIST1H3H,NUDT2,UBC,HSPA1B,MAPK3,TPR,HIST1H2AE,HIST1H2AC,IL6,MAP2K6,TFDP1,CUL2,UBE2D2,HMGA1,UBE2C,TERF1,GPX1
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	1.53476346481184e-08	-17.9923044693721	59	44	0.013986013986014	3146	8202	5689,5693,5683,5713,8454,5716,5720,1452,5566,5715,9491,5708,2737,5687,5696,5688,5701,10213,23198,5717,7314,5686,5567,5694,7311,5692,9978,5702,5695,5710,5685,5691,7316,5704,5719,5706,6233,5709,2932,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,CUL1,PSMD10,PSME1,CSNK1A1,PRKACA,PSMD9,PSMF1,PSMD2,GLI3,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PRKACB,PSMB6,UBA52,PSMB4,RBX1,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,GSK3B,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	1.53476346481184e-08	-17.9923044693721	59	44	0.013986013986014	3146	8202	23291,5689,5693,5683,9039,5713,5716,8454,1147,5720,5715,9491,5708,5687,5696,5688,5701,23198,10213,5717,9020,4791,7314,5970,5686,5694,7311,5692,5702,5695,5710,5685,5691,7316,5704,5719,6233,5706,5709,5690,5705,9861,5700,5711	FBXW11,PSMB1,PSMB5,PSMA2,UBA3,PSMD7,PSMD10,CUL1,CHUK,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSME4,PSMD14,PSMD11,MAP3K14,NFKB2,UBB,RELA,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,RPS27A,PSMC6,PSMD3,PSMB2,PSMC5,PSMD6,PSMC1,PSMD5
R-HSA-195253	Degradation of beta-catenin by the destruction complex	1.69220046580279e-08	-17.8946510111795	81	56	0.0178003814367451	3146	8202	5689,5693,5683,5713,8454,5716,324,1488,5720,1452,5715,9491,5519,5708,5687,5696,1499,5688,5701,10213,23198,5717,7314,5686,5694,7091,7311,5692,9978,7090,5702,139285,5695,23401,5710,5685,5691,7316,6934,5704,5529,5719,5706,6233,10023,5709,5690,2932,5527,3065,9861,5705,5700,1487,5528,5711	PSMB1,PSMB5,PSMA2,PSMD7,CUL1,PSMD10,APC,CTBP2,PSME1,CSNK1A1,PSMD9,PSMF1,PPP2R1B,PSMD2,PSMA6,PSMB8,CTNNB1,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PSMB6,TLE4,UBA52,PSMB4,RBX1,TLE3,PSMC3,AMER1,PSMB7,FRAT2,PSMD4,PSMA4,PSMB3,UBC,TCF7L2,PSMC4,PPP2R5E,PSMD13,PSMC6,RPS27A,FRAT1,PSMD3,PSMB2,GSK3B,PPP2R5C,HDAC1,PSMD6,PSMC5,PSMC1,CTBP1,PPP2R5D,PSMD5
R-HSA-68949	Orc1 removal from chromatin	1.81032613105528e-08	-17.8271737320022	70	50	0.0158931977113795	3146	8202	5689,4175,5693,5683,5713,5716,5720,1026,5715,9491,5708,5687,890,5696,5688,51343,5701,10213,23198,1027,5717,23595,7314,5686,5694,4999,7311,5692,5702,5695,990,5710,5685,5691,7316,5704,5000,5719,5706,6233,5709,5001,84515,5690,9861,5705,5700,5711,23594,4172	PSMB1,MCM6,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,CDKN1A,PSMD9,PSMF1,PSMD2,PSMA6,CCNA2,PSMB8,PSMA7,FZR1,PSMC2,PSMD14,PSME4,CDKN1B,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,PSMC3,PSMB7,CDC6,PSMD4,PSMA4,PSMB3,UBC,PSMC4,ORC4,PSMD13,PSMC6,RPS27A,PSMD3,ORC5,MCM8,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5,ORC6,MCM3
R-HSA-69052	Switching of origins to a post-replicative state	1.81032613105528e-08	-17.8271737320022	70	50	0.0158931977113795	3146	8202	5689,4175,5693,5683,5713,5716,5720,1026,5715,9491,5708,5687,890,5696,5688,51343,5701,10213,23198,1027,5717,23595,7314,5686,5694,4999,7311,5692,5702,5695,990,5710,5685,5691,7316,5704,5000,5719,5706,6233,5709,5001,84515,5690,9861,5705,5700,5711,23594,4172	PSMB1,MCM6,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,CDKN1A,PSMD9,PSMF1,PSMD2,PSMA6,CCNA2,PSMB8,PSMA7,FZR1,PSMC2,PSMD14,PSME4,CDKN1B,PSMD11,ORC3,UBB,PSMA5,PSMB6,ORC2,UBA52,PSMB4,PSMC3,PSMB7,CDC6,PSMD4,PSMA4,PSMB3,UBC,PSMC4,ORC4,PSMD13,PSMC6,RPS27A,PSMD3,ORC5,MCM8,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5,ORC6,MCM3
R-HSA-109581	Apoptosis	1.82935541197312e-08	-17.8167170730424	160	96	0.0305149396058487	3146	8202	5599,836,118,5683,8655,324,5720,598,7531,329,10134,5687,5696,1499,5366,5688,5701,10213,23198,841,578,7311,207,208,842,5695,8743,10971,1832,7532,2934,5719,51765,6233,5706,5709,3009,5690,5533,148022,6093,5705,9861,5700,5711,4137,4836,3146,5689,5693,1676,63967,839,7186,5713,5716,28988,3008,7082,22985,5715,9491,4000,5708,1829,5062,581,5717,10018,7314,3837,5686,6709,5694,5692,5702,56616,5339,5747,5710,26060,5685,5691,1613,7316,5704,840,2339,7027,5534,3148,7534,317,7533,79658,2810	MAPK8,CASP3,ADD1,PSMA2,DYNLL1,APC,PSME1,BCL2L1,YWHAE,BIRC2,BCAP31,PSMA6,PSMB8,CTNNB1,PMAIP1,PSMA7,PSMC2,PSMD14,PSME4,CASP8,BAK1,UBA52,AKT1,AKT2,CASP9,PSMB7,TNFSF10,YWHAQ,DSP,YWHAG,GSN,PSMD13,STK26,RPS27A,PSMC6,PSMD3,HIST1H1B,PSMB2,PPP3CC,TICAM1,ROCK1,PSMC5,PSMD6,PSMC1,PSMD5,MAPT,NMT1,HMGB1,PSMB1,PSMB5,DFFA,CLSPN,CASP6,TRAF2,PSMD7,PSMD10,DBNL,HIST1H1E,TJP1,ACIN1,PSMD9,PSMF1,LMNA,PSMD2,DSG2,PAK2,BAX,PSMD11,BCL2L11,UBB,KPNB1,PSMA5,SPTAN1,PSMB6,PSMB4,PSMC3,DIABLO,PLEC,PTK2,PSMD4,APPL1,PSMA4,PSMB3,DAPK3,UBC,PSMC4,CASP7,FNTA,TFDP1,PPP3R1,HMGB2,YWHAZ,APAF1,YWHAH,ARHGAP10,SFN
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	1.97541498899046e-08	-17.7399022466638	54	41	0.0130324221233312	3146	8202	9871,6256,10654,9453,1387,3422,3157,23054,4520,6721,9632,5901,6309,5469,4801,3837,10498,31,51360,2222,6667,3156,10802,10484,80205,79071,5465,2194,7108,6604,10427,51128,4047,3638,22937,2224,4802,57678,6907,1717,8720	SEC24D,RXRA,PMVK,GGPS1,CREBBP,IDI1,HMGCS1,NCOA6,MTF1,SREBF2,SEC24C,RAN,SC5D,MED1,NFYB,KPNB1,CARM1,ACACA,MBTPS2,FDFT1,SP1,HMGCR,SEC24A,SEC23A,CHD9,ELOVL6,PPARA,FASN,TM7SF2,SMARCD3,SEC24B,SAR1B,LSS,INSIG1,SCAP,FDPS,NFYC,GPAM,TBL1X,DHCR7,MBTPS1
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	1.97541498899046e-08	-17.7399022466638	54	41	0.0130324221233312	3146	8202	5689,5693,5683,5713,8454,5716,5720,5715,9491,26271,5708,5687,5696,5688,51343,5701,10213,23198,5717,7314,5686,5694,7311,5692,5702,991,5695,5710,5685,5691,7316,5704,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,CUL1,PSMD10,PSME1,PSMD9,PSMF1,FBXO5,PSMD2,PSMA6,PSMB8,PSMA7,FZR1,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,CDC20,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	2.39950133895823e-08	-17.5454198036208	49	38	0.0120788302606484	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,5708,5687,5696,5688,5062,5701,10213,23198,5717,7314,5686,5694,7311,5692,5702,5695,5710,5685,5691,7316,5704,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PAK2,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-4086400	PCP/CE pathway	2.44342361921177e-08	-17.5272805654762	91	61	0.019389701207883	3146	8202	5689,5693,1173,5683,8325,5879,5713,5716,5720,2535,5715,5881,9491,7474,5708,5687,5696,5688,5701,10213,23198,163,5717,7314,1856,5686,5694,8321,387,7311,5692,8322,7976,5702,5695,23513,1857,7481,64750,5710,5685,5691,7316,8324,5704,5719,5706,6233,5709,160,1213,6259,5690,7855,9861,5705,409,57154,5700,1175,5711	PSMB1,PSMB5,AP2M1,PSMA2,FZD8,RAC1,PSMD7,PSMD10,PSME1,FZD2,PSMD9,RAC3,PSMF1,WNT5A,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,AP2B1,PSMD11,UBB,DVL2,PSMA5,PSMB6,FZD1,RHOA,UBA52,PSMB4,FZD4,FZD3,PSMC3,PSMB7,SCRIB,DVL3,WNT11,SMURF2,PSMD4,PSMA4,PSMB3,UBC,FZD7,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,AP2A1,CLTC,RYK,PSMB2,FZD5,PSMD6,PSMC5,ARRB2,SMURF1,PSMC1,AP2S1,PSMD5
R-HSA-69202	Cyclin E associated events during G1/S transition	2.59500657785256e-08	-17.4670916925198	65	47	0.0149396058486968	3146	8202	5689,5693,5683,5713,8454,5716,5720,1026,5715,9491,898,7465,5708,5687,890,5696,5688,5701,10213,1163,1027,5717,7314,5686,5694,993,7311,5692,5702,6502,5695,9088,5710,5685,5691,7316,5704,4331,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,CUL1,PSMD10,PSME1,CDKN1A,PSMD9,PSMF1,CCNE1,WEE1,PSMD2,PSMA6,CCNA2,PSMB8,PSMA7,PSMC2,PSMD14,CKS1B,CDKN1B,PSMD11,UBB,PSMA5,PSMB6,CDC25A,UBA52,PSMB4,PSMC3,SKP2,PSMB7,PKMYT1,PSMD4,PSMA4,PSMB3,UBC,PSMC4,MNAT1,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-5357801	Programmed Cell Death	2.76915214026955e-08	-17.4021395571525	163	97	0.0308328035600763	3146	8202	5599,836,118,5683,8655,324,5720,598,7531,329,10134,5687,5696,1499,5366,5688,5701,10213,23198,841,578,7311,330,207,208,842,5695,8743,10971,1832,7532,2934,5719,51765,6233,5706,5709,3009,5690,5533,148022,6093,5705,9861,5700,5711,4137,4836,3146,5689,5693,1676,63967,839,7186,5713,5716,28988,3008,7082,22985,5715,9491,4000,5708,1829,5062,581,5717,10018,7314,3837,5686,6709,5694,5692,5702,56616,5339,5747,5710,26060,5685,5691,7316,1613,5704,840,2339,7027,5534,3148,7534,317,7533,79658,2810	MAPK8,CASP3,ADD1,PSMA2,DYNLL1,APC,PSME1,BCL2L1,YWHAE,BIRC2,BCAP31,PSMA6,PSMB8,CTNNB1,PMAIP1,PSMA7,PSMC2,PSMD14,PSME4,CASP8,BAK1,UBA52,BIRC3,AKT1,AKT2,CASP9,PSMB7,TNFSF10,YWHAQ,DSP,YWHAG,GSN,PSMD13,STK26,RPS27A,PSMC6,PSMD3,HIST1H1B,PSMB2,PPP3CC,TICAM1,ROCK1,PSMC5,PSMD6,PSMC1,PSMD5,MAPT,NMT1,HMGB1,PSMB1,PSMB5,DFFA,CLSPN,CASP6,TRAF2,PSMD7,PSMD10,DBNL,HIST1H1E,TJP1,ACIN1,PSMD9,PSMF1,LMNA,PSMD2,DSG2,PAK2,BAX,PSMD11,BCL2L11,UBB,KPNB1,PSMA5,SPTAN1,PSMB6,PSMB4,PSMC3,DIABLO,PLEC,PTK2,PSMD4,APPL1,PSMA4,PSMB3,UBC,DAPK3,PSMC4,CASP7,FNTA,TFDP1,PPP3R1,HMGB2,YWHAZ,APAF1,YWHAH,ARHGAP10,SFN
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	3.02094221627728e-08	-17.3151119690802	58	43	0.0136681500317864	3146	8202	23291,5689,5693,5683,9039,5713,5716,8454,1147,5720,5715,9491,5708,5687,5696,5688,5701,23198,10213,5717,9020,4791,7314,5686,5694,7311,5692,5702,5695,5710,5685,5691,7316,5704,5719,6233,5706,5709,5690,5705,9861,5700,5711	FBXW11,PSMB1,PSMB5,PSMA2,UBA3,PSMD7,PSMD10,CUL1,CHUK,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSME4,PSMD14,PSMD11,MAP3K14,NFKB2,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,RPS27A,PSMC6,PSMD3,PSMB2,PSMC5,PSMD6,PSMC1,PSMD5
R-HSA-5419276	Mitochondrial translation termination	3.61019094360389e-08	-17.1369200800413	84	57	0.0181182453909727	3146	8202	51373,65080,28977,54148,124995,64949,3396,51263,29093,84340,9801,64963,10884,56945,54534,10240,740,23107,55037,6183,116541,51023,64975,64976,219927,29088,64951,51253,51650,51258,84545,6182,90480,55173,60488,122704,64928,63931,64979,51318,51081,55052,54460,10573,51069,7818,128308,64978,51649,64432,118487,9553,51264,28957,51021,11222,54998	MRPS17,MRPL44,MRPL42,MRPL39,MRPL10,MRPS26,ICT1,MRPL30,MRPL22,GFM2,MRPL19,MRPS11,MRPS30,MRPS22,MRPL50,MRPS31,MRPL49,MRPS27,PTCD3,MRPS12,MRPL54,MRPS18C,MRPL41,MRPL40,MRPL21,MRPL15,MRPS24,MRPL37,MRPS33,MRPL51,MRPL43,MRPL12,GADD45GIP1,MRPS10,MRPS35,MRPL52,MRPL14,MRPS14,MRPL36,MRPL35,MRPS7,MRPL20,MRPS21,MRPL28,MRPL2,DAP3,MRPL55,MRPL38,MRPS23,MRPS25,CHCHD1,MRPL33,MRPL27,MRPS28,MRPS16,MRPL3,AURKAIP1
R-HSA-69615	G1/S DNA Damage Checkpoints	3.62309966827531e-08	-17.1333508225433	60	44	0.013986013986014	3146	8202	5689,5693,5683,5713,5716,1111,5720,1026,5715,9491,898,5708,4193,5687,5696,5688,5701,10213,23198,1027,5717,7314,5686,5694,993,7311,5692,5702,5695,5710,5685,5691,7316,5704,64326,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,CHEK1,PSME1,CDKN1A,PSMD9,PSMF1,CCNE1,PSMD2,MDM2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,CDKN1B,PSMD11,UBB,PSMA5,PSMB6,CDC25A,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,RFWD2,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-5663202	Diseases of signal transduction	3.93682954663587e-08	-17.0503050281691	268	146	0.0464081373172282	3146	8202	142678,11116,7249,8805,102,8454,5720,6777,1488,1026,10013,5519,23493,1387,5696,1499,5688,5296,5701,5664,611,10818,26127,64223,7311,9978,51107,208,842,1523,5335,4087,5719,6233,399687,5690,4254,5527,2932,3065,5705,5528,5700,2549,3066,5689,5693,64840,5713,83933,83464,5715,57534,51564,4040,9794,5686,139285,5702,8841,84447,5685,5691,6934,5704,2069,6907,9611,1487,2033,685,54567,2475,5683,2064,324,1147,8658,9372,5687,4193,182,6464,23198,10213,8503,1027,253260,11052,55534,79412,2931,207,8322,5695,10014,2260,8660,4088,5529,2534,9759,5706,51009,5709,10046,9861,23385,4089,5711,8325,79109,5716,1452,9491,2309,5708,22938,5781,5717,3320,2065,7314,6774,6199,5694,5170,3280,6868,1024,5692,4303,2648,6654,3164,5295,5710,54492,222236,7316,22943,2885,6776,3516,7855,3265	MIB2,FGFR1OP,TSC2,TRIM24,ADAM10,CUL1,PSME1,STAT5B,CTBP2,CDKN1A,HDAC6,PPP2R1B,HEY2,CREBBP,PSMB8,CTNNB1,PSMA7,PIK3R2,PSMC2,PSEN2,OPN1SW,FRS2,FGFR1OP2,MLST8,UBA52,RBX1,APH1A,AKT2,CASP9,CUX1,PLCG1,SMAD2,PSMD13,RPS27A,MYO18A,PSMB2,KITLG,PPP2R5C,GSK3B,HDAC1,PSMC5,PPP2R5D,PSMC1,GAB1,HDAC2,PSMB1,PSMB5,PORCN,PSMD7,HDAC10,APH1B,PSMD9,MIB1,HDAC7,LRP6,MAML1,PSMA5,AMER1,PSMC3,HDAC3,SYVN1,PSMA4,PSMB3,TCF7L2,PSMC4,EREG,TBL1X,NCOR1,CTBP1,EP300,BTC,DLL4,MTOR,PSMA2,ERBB2,APC,CHUK,TNKS,ZFYVE9,PSMA6,MDM2,JAG1,SHC1,PSME4,PSMD14,PIK3R3,CDKN1B,RICTOR,CPSF6,MAML3,KREMEN2,GSK3A,AKT1,FZD4,PSMB7,HDAC5,FGFR1,IRS2,SMAD3,PPP2R5E,FYN,HDAC4,PSMC6,DERL2,PSMD3,MAMLD1,PSMD6,NCSTN,SMAD4,PSMD5,FZD8,MAPKAP1,PSMD10,CSNK1A1,PSMF1,FOXO3,PSMD2,SNW1,PTPN11,PSMD11,HSP90AA1,ERBB3,UBB,STAT3,RPS6KB2,PSMB6,PDPK1,HES1,ADAM17,CDK8,PSMB4,FOXO4,KAT2A,SOS1,NR4A1,PIK3R1,PSMD4,NEURL1B,NAPEPLD,UBC,DKK1,GRB2,STAT5A,RBPJ,FZD5,HRAS
R-HSA-180585	Vif-mediated degradation of APOBEC3G	3.95677004900903e-08	-17.0452526956943	53	40	0.0127145581691036	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,5708,5696,5687,5688,5701,23198,10213,5717,7314,5686,5694,7311,6923,5692,9978,5702,5695,6921,5710,5685,7316,5691,5704,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMB8,PSMA6,PSMA7,PSMC2,PSME4,PSMD14,PSMD11,UBB,PSMA5,PSMB6,UBA52,TCEB2,PSMB4,RBX1,PSMC3,PSMB7,TCEB1,PSMD4,PSMA4,UBC,PSMB3,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-2871837	FCERI mediated NF-kB activation	5.18280722941416e-08	-16.775333898295	77	53	0.0168467895740623	3146	8202	23291,5689,5693,5683,257397,5713,5716,8454,1147,5720,4067,5715,9491,5708,5696,5687,5688,3551,5701,23198,10213,5717,7321,7314,5970,5686,5694,5170,7311,5692,5702,5695,10892,7335,5710,5685,5691,7316,5704,997,5719,23118,6233,5706,5709,7322,5690,5705,9861,10454,5700,7334,5711	FBXW11,PSMB1,PSMB5,PSMA2,TAB3,PSMD7,PSMD10,CUL1,CHUK,PSME1,LYN,PSMD9,PSMF1,PSMD2,PSMB8,PSMA6,PSMA7,IKBKB,PSMC2,PSME4,PSMD14,PSMD11,UBE2D1,UBB,RELA,PSMA5,PSMB6,PDPK1,UBA52,PSMB4,PSMC3,PSMB7,MALT1,UBE2V1,PSMD4,PSMA4,PSMB3,UBC,PSMC4,CDC34,PSMD13,TAB2,RPS27A,PSMC6,PSMD3,UBE2D2,PSMB2,PSMC5,PSMD6,TAB1,PSMC1,UBE2N,PSMD5
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	5.67224415364763e-08	-16.6850959102245	66	47	0.0149396058486968	3146	8202	5689,5693,5683,5713,8454,5716,5720,1026,5715,9491,898,7465,5708,5687,890,5696,5688,51343,5701,10213,1163,1027,5717,7314,5686,5694,993,7311,5692,5702,6502,5695,5710,5685,5691,7316,5704,4331,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,CUL1,PSMD10,PSME1,CDKN1A,PSMD9,PSMF1,CCNE1,WEE1,PSMD2,PSMA6,CCNA2,PSMB8,PSMA7,FZR1,PSMC2,PSMD14,CKS1B,CDKN1B,PSMD11,UBB,PSMA5,PSMB6,CDC25A,UBA52,PSMB4,PSMC3,SKP2,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,MNAT1,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	5.91180555895235e-08	-16.6437294500638	57	42	0.0133502860775588	3146	8202	5689,5693,5683,5713,5716,5720,1026,5715,9491,898,5708,4193,5687,5696,5688,5701,10213,23198,1027,5717,7314,5686,5694,7311,5692,5702,5695,5710,5685,5691,7316,5704,64326,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,CDKN1A,PSMD9,PSMF1,CCNE1,PSMD2,MDM2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,CDKN1B,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,RFWD2,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-69563	p53-Dependent G1 DNA Damage Response	5.91180555895235e-08	-16.6437294500638	57	42	0.0133502860775588	3146	8202	5689,5693,5683,5713,5716,5720,1026,5715,9491,898,5708,4193,5687,5696,5688,5701,10213,23198,1027,5717,7314,5686,5694,7311,5692,5702,5695,5710,5685,5691,7316,5704,64326,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,CDKN1A,PSMD9,PSMF1,CCNE1,PSMD2,MDM2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,CDKN1B,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,RFWD2,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-611105	Respiratory electron transport	6.05826258823573e-08	-16.6192576865892	81	55	0.0174825174825175	3146	8202	1329,4729,51204,4719,4712,7381,6391,29796,4711,4697,4706,1327,51079,51241,374291,4724,4709,137682,9997,4723,4695,4710,1337,2108,4714,7385,4715,4731,1349,10975,4700,4705,4696,55967,4720,285521,4704,1350,4717,51300,27089,1353,7384,116228,6392,25915,9167,10128,4694,1351,7388,79133,6341,4702,4713	COX5B,NDUFV2,TACO1,NDUFS1,NDUFB6,UQCRB,SDHC,UQCR10,NDUFB5,NDUFA4,NDUFAB1,COX4I1,NDUFA13,COX16,NDUFS7,NDUFS4,NDUFB3,NDUFAF6,SCO2,NDUFV1,NDUFA2,NDUFB4,COX6A1,ETFA,NDUFB8,UQCRC2,NDUFB9,NDUFV3,COX7B,UQCR11,NDUFA6,NDUFA10,NDUFA3,NDUFA12,NDUFS2,COX18,NDUFA9,COX7C,NDUFC1,TIMMDC1,UQCRQ,COX11,UQCRC1,COX20,SDHD,NDUFAF3,COX7A2L,LRPPRC,NDUFA1,COX8A,UQCRH,NDUFAF5,SCO1,NDUFA8,NDUFB7
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	6.30292008243728e-08	-16.5796677127914	50	38	0.0120788302606484	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,5708,5687,5696,5688,5701,10213,23198,5717,7314,5686,5694,7311,5692,5702,5695,990,5710,5685,5691,7316,5704,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,CDC6,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	6.30292008243728e-08	-16.5796677127914	50	38	0.0120788302606484	3146	8202	5689,5693,5683,5713,51686,5716,5720,5715,9491,5708,5687,5696,5688,5701,10213,23198,51582,5717,5686,5694,5692,5702,5695,5710,4953,5685,5691,5704,5719,5706,5709,4947,5690,9861,5705,5700,4946,5711	PSMB1,PSMB5,PSMA2,PSMD7,OAZ3,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,AZIN1,PSMD11,PSMA5,PSMB6,PSMB4,PSMC3,PSMB7,PSMD4,ODC1,PSMA4,PSMB3,PSMC4,PSMD13,PSMC6,PSMD3,OAZ2,PSMB2,PSMD6,PSMC5,PSMC1,OAZ1,PSMD5
R-HSA-195258	RHO GTPase Effectors	6.68115599759099e-08	-16.5213897178443	285	153	0.0486331849968214	3146	8202	10398,3015,8936,71,8358,8350,11004,7531,81624,4628,5519,79003,8365,9183,1499,8366,51517,8379,2017,10097,147179,8331,81929,8352,1058,4690,64105,9212,25936,1535,3984,3688,5527,60,6093,5528,4659,1495,389,3831,808,5217,10092,5062,9735,79902,114793,9475,3985,8968,10152,23191,23433,8368,10552,388,10458,23421,29941,4660,7534,286205,10109,54820,3619,2810,8354,391,10163,57405,5048,8826,5879,10096,348995,23028,25909,55845,8364,57122,30851,1027,4637,1856,81565,348235,57120,991,1742,10971,1857,6232,995,79682,7532,8294,3796,5903,5529,7514,79980,8976,8351,4085,3014,5500,6722,23122,8338,3020,151648,5594,6396,8367,11113,89953,54821,10093,5501,8360,121504,9793,3799,25,5586,55920,151246,9055,653604,699,55166,79019,8345,10726,5170,387,11130,5905,5747,4221,8357,220134,1729,5595,401541,2885,6249,3012,81930,8334,147841,57082,7533	MYL9,H2AFZ,WASF1,ACTG1,HIST1H3B,HIST1H3A,KIF2C,YWHAE,DIAPH3,MYH10,PPP2R1B,MIS12,HIST1H4H,ZW10,CTNNB1,HIST1H4B,NCKIPSD,MAD1L1,CTTN,ACTR2,WIPF2,HIST1H2AJ,SEH1L,HIST1H3C,CENPA,NCK1,CENPK,AURKB,NSL1,CYBA,LIMK1,ITGB1,PPP2R5C,ACTB,ROCK1,PPP2R5D,PPP1R12A,CTNNA1,RHOC,KLC1,CALM3,PFN2,ARPC5,PAK2,KNTC1,NUP85,FMNL2,ROCK2,LIMK2,HIST1H3F,ABI2,CYFIP1,RHOQ,HIST1H4L,ARPC1A,RHOB,BAIAP2,ITGB3BP,PKN3,PPP1R12B,YWHAZ,SCAI,ARPC2,NDE1,INCENP,SFN,HIST1H3I,RHOG,WASF2,SPC25,PAFAH1B1,IQGAP1,RAC1,ACTR3,NUP43,KDM1A,AHCTF1,BRK1,HIST1H4C,NUP107,TAX1BP3,CDKN1B,MYL6,DVL2,NDEL1,SKA2,GOPC,CDC20,DLG4,YWHAQ,DVL3,RPS27,CDC25C,CENPU,YWHAG,HIST1H4I,KIF2A,RANBP2,PPP2R5E,XPO1,DSN1,WASL,HIST1H3D,MAD2L1,H2AFX,PPP1CB,SRF,CLASP2,HIST2H2AC,H3F3A,SGOL1,MAPK1,SEC13,HIST1H4E,CIT,KLC4,ERCC6L,ARPC4,PPP1CC,HIST1H4D,HIST4H4,CKAP5,KIF5B,ABL1,PKN2,RCC2,SGOL2,PRC1,HIST2H3D,BUB1,CENPQ,CENPM,HIST1H2BH,NUDC,PDPK1,RHOA,ZWINT,RANGAP1,PTK2,MEN1,HIST1H3H,SKA1,DIAPH1,MAPK3,CENPP,GRB2,CLIP1,HIST1H2AE,KIF18A,HIST1H2AC,SPC24,CASC5,YWHAH
R-HSA-5610780	Degradation of GLI1 by the proteasome	7.01504761058035e-08	-16.472623243453	59	43	0.0136681500317864	3146	8202	5689,5693,5683,5713,8454,5716,5720,5566,5715,9491,5708,5687,5696,5688,5701,10213,23198,5717,7314,5686,5567,5694,7311,5692,9978,83737,5702,5695,5710,5685,5691,7316,5704,5719,5706,6233,5709,5690,9861,5705,5700,5711,8650	PSMB1,PSMB5,PSMA2,PSMD7,CUL1,PSMD10,PSME1,PRKACA,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PRKACB,PSMB6,UBA52,PSMB4,RBX1,ITCH,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5,NUMB
R-HSA-5610783	Degradation of GLI2 by the proteasome	7.01504761058035e-08	-16.472623243453	59	43	0.0136681500317864	3146	8202	5689,5693,5683,5713,8454,5716,5720,1452,5566,5715,9491,5708,5687,5696,5688,5701,10213,23198,5717,7314,5686,5567,5694,7311,5692,9978,5702,5695,5710,5685,5691,7316,5704,5719,5706,6233,5709,2932,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,CUL1,PSMD10,PSME1,CSNK1A1,PRKACA,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PRKACB,PSMB6,UBA52,PSMB4,RBX1,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,GSK3B,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	7.87878725510108e-08	-16.3565067535636	52	39	0.012396694214876	3146	8202	5689,5693,5683,5713,5716,1111,5720,5715,9491,5708,5687,5696,5688,5701,10213,23198,5717,7314,5686,5694,993,7311,5692,5702,5695,5710,5685,5691,7316,5704,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,CHEK1,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PSMB6,CDC25A,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	7.87878725510108e-08	-16.3565067535636	52	39	0.012396694214876	3146	8202	5689,5693,5683,5713,5716,1111,5720,5715,9491,5708,5687,5696,5688,5701,10213,23198,5717,7314,5686,5694,993,7311,5692,5702,5695,5710,5685,5691,7316,5704,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,CHEK1,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PSMB6,CDC25A,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-69541	Stabilization of p53	7.87878725510108e-08	-16.3565067535636	52	39	0.012396694214876	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,5708,4193,5687,5696,5688,5701,10213,23198,5717,7314,5686,5694,7311,5692,5702,5695,5710,5685,5691,7316,5704,64326,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,MDM2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,RFWD2,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-69610	p53-Independent DNA Damage Response	7.87878725510108e-08	-16.3565067535636	52	39	0.012396694214876	3146	8202	5689,5693,5683,5713,5716,1111,5720,5715,9491,5708,5687,5696,5688,5701,10213,23198,5717,7314,5686,5694,993,7311,5692,5702,5695,5710,5685,5691,7316,5704,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,CHEK1,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PSMB6,CDC25A,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-4641257	Degradation of AXIN	9.617784506096e-08	-16.1570668066197	54	40	0.0127145581691036	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,8658,5708,5687,5696,5688,5701,10213,23198,5717,7314,5686,5694,7311,5692,5702,5695,64750,5710,5685,5691,7316,5704,5719,5706,6233,5709,5690,9861,5705,5700,5711,81847	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,TNKS,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,SMURF2,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5,RNF146
R-HSA-4641258	Degradation of DVL	1.14994849720923e-07	-15.9783784946215	56	41	0.0130324221233312	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,5708,5687,5696,5688,5701,10213,23198,5717,7314,1856,5686,5694,7311,5692,9978,5702,8452,5695,1857,5710,5685,5691,7316,5704,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,DVL2,PSMA5,PSMB6,UBA52,PSMB4,RBX1,PSMC3,CUL3,PSMB7,DVL3,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-5658442	Regulation of RAS by GAPs	1.1959135833921e-07	-15.9391852527293	67	47	0.0149396058486968	3146	8202	200734,161742,5689,5693,9462,4763,5683,5713,5716,5720,5715,9491,5708,5696,5687,5688,5701,23198,10213,5717,7314,5686,5694,7311,5692,9978,5702,5695,8452,8437,5710,5685,5691,5921,7316,5704,5719,6233,5706,5709,84078,5690,5705,9861,5700,3265,5711	SPRED2,SPRED1,PSMB1,PSMB5,RASAL2,NF1,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMB8,PSMA6,PSMA7,PSMC2,PSME4,PSMD14,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,RBX1,PSMC3,PSMB7,CUL3,RASAL1,PSMD4,PSMA4,PSMB3,RASA1,UBC,PSMC4,PSMD13,RPS27A,PSMC6,PSMD3,KBTBD7,PSMB2,PSMC5,PSMD6,PSMC1,HRAS,PSMD5
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	1.55922139516463e-07	-15.6739090599553	51	38	0.0120788302606484	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,5708,5687,5696,5688,5701,10213,23198,5717,7314,5686,5694,7311,5692,5702,5695,5710,5685,5691,7316,5704,64326,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,RFWD2,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-1236974	ER-Phagosome pathway	1.99571819342314e-07	-15.4270916686964	64	45	0.0143038779402416	3146	8202	5689,5693,5683,6890,5713,5716,2923,567,5720,5715,9491,3105,811,5708,5696,5687,5688,5701,23198,10213,5717,6891,7314,5686,55176,5694,7311,5692,5702,5695,5710,5685,5691,7316,5704,5719,29927,6233,5706,5709,5690,5705,9861,5700,5711	PSMB1,PSMB5,PSMA2,TAP1,PSMD7,PSMD10,PDIA3,B2M,PSME1,PSMD9,PSMF1,HLA-A,CALR,PSMD2,PSMB8,PSMA6,PSMA7,PSMC2,PSME4,PSMD14,PSMD11,TAP2,UBB,PSMA5,SEC61A2,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,SEC61A1,RPS27A,PSMC6,PSMD3,PSMB2,PSMC5,PSMD6,PSMC1,PSMD5
R-HSA-162599	Late Phase of HIV Life Cycle	2.55978884602017e-07	-15.1781708778921	127	77	0.0244755244755245	3146	8202	23511,2071,51510,348995,404672,57122,9972,6917,5901,6882,81929,25920,6881,6877,7311,5436,6923,5441,8731,9525,5433,9631,25978,8021,5432,6873,905,5903,6827,7514,6233,7251,27183,6749,92421,4836,51497,6884,9150,6872,6908,5440,8480,102157402,23165,9883,129401,5478,2962,8178,83860,5902,2963,2068,7314,2959,79902,5438,7936,5045,6921,5905,55048,6875,6829,7316,9397,5430,4331,7175,2957,1104,5434,22916,23636,6883,6878	NUP188,ERCC3,CHMP5,NUP43,GTF2H5,NUP107,NUP153,TCEA1,RAN,TAF11,SEH1L,NELFB,TAF10,TAF5,UBA52,POLR2G,TCEB2,POLR2L,RNMT,VPS4B,POLR2D,NUP155,CHMP2B,NUP214,POLR2C,TAF2,CCNT2,RANBP2,SUPT4H1,XPO1,RPS27A,TSG101,VPS4A,SSRP1,CHMP4C,NMT1,NELFCD,TAF13,CTDP1,TAF1,TBP,POLR2K,RAE1,AK6,NUP205,POM121,NUP35,PPIA,GTF2F1,ELL,TAF3,RANBP1,GTF2F2,ERCC2,UBB,GTF2B,NUP85,POLR2I,NELFE,FURIN,TCEB1,RANGAP1,VPS37C,TAF4B,SUPT5H,UBC,NMT2,POLR2A,MNAT1,TPR,GTF2A1,RCC1,POLR2E,NCBP2,NUP62,TAF12,TAF6
R-HSA-5607764	CLEC7A (Dectin-1) signaling	2.70068180961522e-07	-15.1245913877467	99	63	0.0200254291163382	3146	8202	23291,5689,5693,5683,257397,9039,5713,5716,808,8454,1147,5720,5532,3709,5715,9491,5708,5696,5687,5688,3551,5701,23198,10213,5717,9020,4791,841,7321,10768,7314,5970,5686,5694,5170,7311,5692,5702,5695,10892,7335,5710,3710,5685,5691,7316,5704,5719,997,23118,6233,5706,5709,3708,7322,5534,5690,5705,9861,10454,5700,7334,5711	FBXW11,PSMB1,PSMB5,PSMA2,TAB3,UBA3,PSMD7,PSMD10,CALM3,CUL1,CHUK,PSME1,PPP3CB,ITPR2,PSMD9,PSMF1,PSMD2,PSMB8,PSMA6,PSMA7,IKBKB,PSMC2,PSME4,PSMD14,PSMD11,MAP3K14,NFKB2,CASP8,UBE2D1,AHCYL1,UBB,RELA,PSMA5,PSMB6,PDPK1,UBA52,PSMB4,PSMC3,PSMB7,MALT1,UBE2V1,PSMD4,ITPR3,PSMA4,PSMB3,UBC,PSMC4,PSMD13,CDC34,TAB2,RPS27A,PSMC6,PSMD3,ITPR1,UBE2D2,PPP3R1,PSMB2,PSMC5,PSMD6,TAB1,PSMC1,UBE2N,PSMD5
R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1	3.06600521581377e-07	-14.9977201693315	50	37	0.0117609663064209	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,5708,5687,5696,5688,5701,10213,23198,5717,7314,5686,5694,7311,5692,5702,5695,5710,5685,7316,5691,5704,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,UBC,PSMB3,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	3.06600521581377e-07	-14.9977201693315	50	37	0.0117609663064209	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,5708,5687,5696,5688,5701,10213,23198,5717,7314,5686,5694,7311,5692,5702,5695,5710,5685,7316,5691,5704,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,UBC,PSMB3,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-429914	Deadenylation-dependent mRNA decay	3.06600521581377e-07	-14.9977201693315	50	37	0.0117609663064209	3146	8202	23019,51010,255967,9337,196513,25804,29883,85456,55571,5073,9924,4849,80153,23016,23658,9775,1656,56915,54512,27257,4850,1977,26986,23404,118460,1974,51690,23644,5393,219988,9125,4848,1981,11157,57819,57472,54464	CNOT1,EXOSC3,PAN3,CNOT8,DCP1B,LSM4,CNOT7,TNKS1BP1,CNOT11,PARN,PAN2,CNOT3,EDC3,EXOSC7,LSM5,EIF4A3,DDX6,EXOSC5,EXOSC4,LSM1,CNOT4,EIF4E,PABPC1,EXOSC2,EXOSC6,EIF4A2,LSM7,EDC4,EXOSC9,PATL1,RQCD1,CNOT2,EIF4G1,LSM6,LSM2,CNOT6,XRN1
R-HSA-162587	HIV Life Cycle	3.47909941197226e-07	-14.8713221803269	140	83	0.02638270820089	3146	8202	23511,2071,51510,348995,404672,57122,9972,6917,5901,6882,81929,25920,6881,6877,7311,5436,6923,5441,8731,9525,5433,9631,25978,8021,5432,6873,905,5903,6827,7514,6233,7251,27183,6749,92421,4836,51497,6884,9150,6872,6908,5440,8480,102157402,3978,11168,23165,9883,129401,5478,2962,8178,83860,5902,2963,2068,7314,2959,79902,5438,7936,5045,3981,6921,5905,6875,55048,6829,5430,7316,9397,7520,4331,7175,7852,2957,1104,5434,22916,23636,3159,6883,6878	NUP188,ERCC3,CHMP5,NUP43,GTF2H5,NUP107,NUP153,TCEA1,RAN,TAF11,SEH1L,NELFB,TAF10,TAF5,UBA52,POLR2G,TCEB2,POLR2L,RNMT,VPS4B,POLR2D,NUP155,CHMP2B,NUP214,POLR2C,TAF2,CCNT2,RANBP2,SUPT4H1,XPO1,RPS27A,TSG101,VPS4A,SSRP1,CHMP4C,NMT1,NELFCD,TAF13,CTDP1,TAF1,TBP,POLR2K,RAE1,AK6,LIG1,PSIP1,NUP205,POM121,NUP35,PPIA,GTF2F1,ELL,TAF3,RANBP1,GTF2F2,ERCC2,UBB,GTF2B,NUP85,POLR2I,NELFE,FURIN,LIG4,TCEB1,RANGAP1,TAF4B,VPS37C,SUPT5H,POLR2A,UBC,NMT2,XRCC5,MNAT1,TPR,CXCR4,GTF2A1,RCC1,POLR2E,NCBP2,NUP62,HMGA1,TAF12,TAF6
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	4.58636553366411e-07	-14.5950077632742	100	63	0.0200254291163382	3146	8202	6396,57405,5048,54821,11004,348995,891,5501,5519,79003,9793,9183,55920,9126,25909,151246,57122,8379,699,55166,9735,79019,79902,81929,10726,11130,81565,1058,348235,10274,991,10735,5905,6232,64105,9212,220134,983,79682,23244,401541,3796,5903,5529,6249,7514,81930,79980,25936,23421,23063,4085,113130,8243,5527,147841,23122,54820,57082,151648,3619,9133,5528	SEC13,SPC25,PAFAH1B1,ERCC6L,KIF2C,NUP43,CCNB1,PPP1CC,PPP2R1B,MIS12,CKAP5,ZW10,RCC2,SMC3,AHCTF1,SGOL2,NUP107,MAD1L1,BUB1,CENPQ,KNTC1,CENPM,NUP85,SEH1L,NUDC,ZWINT,NDEL1,CENPA,SKA2,STAG1,CDC20,STAG2,RANGAP1,RPS27,CENPK,AURKB,SKA1,CDK1,CENPU,PDS5A,CENPP,KIF2A,RANBP2,PPP2R5E,CLIP1,XPO1,KIF18A,DSN1,NSL1,ITGB3BP,WAPL,MAD2L1,CDCA5,SMC1A,PPP2R5C,SPC24,CLASP2,NDE1,CASC5,SGOL1,INCENP,CCNB2,PPP2R5D
R-HSA-194315	Signaling by Rho GTPases	6.42802452862738e-07	-14.2574283871869	399	200	0.0635727908455181	3146	8202	10398,23092,3015,8936,71,8358,8350,11004,7531,81624,10144,4628,5881,5519,79003,8365,9183,1499,8366,5296,51517,8379,2017,10097,147179,9754,8331,6453,81929,8352,1058,4690,23526,64105,9212,1535,25936,3984,3688,5527,60,6093,9411,90627,5528,64857,2245,64411,4659,9886,1495,389,7410,7204,4983,3831,808,5217,10092,4952,5062,57522,9735,9475,79902,114793,3985,8968,10152,23191,23433,84033,8368,10552,388,10458,23421,29941,116985,171177,4660,94134,7534,286205,10109,4649,54820,3619,79658,2810,8354,391,10163,57405,5048,91614,10928,8826,10096,58504,5879,348995,23028,25909,55845,8364,57122,30851,1027,4637,9828,57514,1856,89839,6655,55114,81565,348235,57120,991,1742,10971,1857,6232,11214,995,7532,79682,8294,3796,5903,5529,7514,79980,8976,8351,4085,3014,396,5500,6722,23122,8338,3020,151648,5594,6396,50650,8367,11113,89953,54821,10093,5501,8360,84144,9793,121504,3799,25,5586,57449,55920,151246,9055,9181,653604,392,55166,699,8345,79019,10726,5170,11130,55789,387,6654,10276,80728,5905,23365,5747,55288,4221,8357,220134,1729,5595,401541,2885,6249,3012,81930,8334,147841,57082,7533,57636,23229	MYL9,ARHGAP26,H2AFZ,WASF1,ACTG1,HIST1H3B,HIST1H3A,KIF2C,YWHAE,DIAPH3,FAM13A,MYH10,RAC3,PPP2R1B,MIS12,HIST1H4H,ZW10,CTNNB1,HIST1H4B,PIK3R2,NCKIPSD,MAD1L1,CTTN,ACTR2,WIPF2,STARD8,HIST1H2AJ,ITSN1,SEH1L,HIST1H3C,CENPA,NCK1,HMHA1,CENPK,AURKB,CYBA,NSL1,LIMK1,ITGB1,PPP2R5C,ACTB,ROCK1,ARHGAP29,STARD13,PPP2R5D,PLEKHG2,FGD1,ARAP3,PPP1R12A,RHOBTB1,CTNNA1,RHOC,VAV2,TRIO,OPHN1,KLC1,CALM3,PFN2,ARPC5,OCRL,PAK2,SRGAP1,KNTC1,ROCK2,NUP85,FMNL2,LIMK2,HIST1H3F,ABI2,CYFIP1,RHOQ,OBSCN,HIST1H4L,ARPC1A,RHOB,BAIAP2,ITGB3BP,PKN3,ARAP1,RHOV,PPP1R12B,ARHGAP12,YWHAZ,SCAI,ARPC2,MYO9A,NDE1,INCENP,ARHGAP10,SFN,HIST1H3I,RHOG,WASF2,SPC25,PAFAH1B1,DEPDC7,RALBP1,IQGAP1,ACTR3,ARHGAP22,RAC1,NUP43,KDM1A,AHCTF1,BRK1,HIST1H4C,NUP107,TAX1BP3,CDKN1B,MYL6,ARHGEF17,ARHGAP31,DVL2,ARHGAP11B,SOS2,ARHGAP17,NDEL1,SKA2,GOPC,CDC20,DLG4,YWHAQ,DVL3,RPS27,AKAP13,CDC25C,YWHAG,CENPU,HIST1H4I,KIF2A,RANBP2,PPP2R5E,XPO1,DSN1,WASL,HIST1H3D,MAD2L1,H2AFX,ARHGDIA,PPP1CB,SRF,CLASP2,HIST2H2AC,H3F3A,SGOL1,MAPK1,SEC13,ARHGEF3,HIST1H4E,CIT,KLC4,ERCC6L,ARPC4,PPP1CC,HIST1H4D,SYDE2,CKAP5,HIST4H4,KIF5B,ABL1,PKN2,PLEKHG5,RCC2,SGOL2,PRC1,ARHGEF2,HIST2H3D,ARHGAP1,CENPQ,BUB1,HIST1H2BH,CENPM,NUDC,PDPK1,ZWINT,DEPDC1B,RHOA,SOS1,NET1,ARHGAP39,RANGAP1,ARHGEF12,PTK2,RHOT1,MEN1,HIST1H3H,SKA1,DIAPH1,MAPK3,CENPP,GRB2,CLIP1,HIST1H2AE,KIF18A,HIST1H2AC,SPC24,CASC5,YWHAH,ARHGAP23,ARHGEF9
R-HSA-180534	Vpu mediated degradation of CD4	7.04821959874874e-07	-14.1653206052121	51	37	0.0117609663064209	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,5708,5696,5687,5688,5701,23198,10213,5717,7314,5686,5694,7311,5692,5702,5695,5710,5685,7316,5691,5704,5719,5706,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMB8,PSMA6,PSMA7,PSMC2,PSME4,PSMD14,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,UBC,PSMB3,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-453274	Mitotic G2-G2/M phases	7.11873297742795e-07	-14.1553658939783	117	71	0.0225683407501589	3146	8202	2033,23291,10142,11116,5116,80321,10383,5048,8655,5520,8454,7531,891,5566,5519,132660,286826,7465,4218,890,84131,10733,80254,7311,1454,1871,114791,121441,9088,79959,995,983,7532,10133,4926,7514,6233,5500,7840,203068,55957,11258,1781,4659,984,55142,9793,9702,80184,55835,85378,4751,3320,7314,993,55755,4605,22994,79866,7316,4331,5108,4957,10806,8481,6790,4660,54820,55125,9133,91750	EP300,FBXW11,AKAP9,FGFR1OP,PCNT,CEP70,TUBB4B,PAFAH1B1,DYNLL1,PPP2R2A,CUL1,YWHAE,CCNB1,PRKACA,PPP2R1B,LIN54,LIN9,WEE1,RAB8A,CCNA2,CEP78,PLK4,CEP63,UBA52,CSNK1E,E2F3,TUBGCP5,NEDD1,PKMYT1,CEP76,CDC25C,CDK1,YWHAG,OPTN,NUMA1,XPO1,RPS27A,PPP1CB,ALMS1,TUBB,LIN37,DCTN3,DYNC1I2,PPP1R12A,CDK11B,HAUS2,CKAP5,CEP57,CEP290,CENPJ,TUBGCP6,NEK2,HSP90AA1,UBB,CDC25A,CDK5RAP2,MYBL2,CEP131,BORA,UBC,MNAT1,PCM1,ODF2,SDCCAG8,OFD1,AURKA,PPP1R12B,NDE1,CEP192,CCNB2,LIN52
R-HSA-69275	G2/M Transition	7.23168879856477e-07	-14.1396230599662	115	70	0.0222504767959313	3146	8202	2033,23291,10142,11116,5116,80321,10383,5048,8655,5520,8454,7531,891,5566,5519,132660,286826,7465,4218,890,84131,10733,80254,7311,1454,114791,121441,9088,79959,995,983,7532,10133,4926,7514,6233,5500,7840,203068,55957,11258,1781,4659,984,55142,9793,9702,80184,55835,85378,4751,3320,7314,993,55755,4605,22994,79866,7316,4331,5108,4957,10806,8481,6790,4660,54820,55125,9133,91750	EP300,FBXW11,AKAP9,FGFR1OP,PCNT,CEP70,TUBB4B,PAFAH1B1,DYNLL1,PPP2R2A,CUL1,YWHAE,CCNB1,PRKACA,PPP2R1B,LIN54,LIN9,WEE1,RAB8A,CCNA2,CEP78,PLK4,CEP63,UBA52,CSNK1E,TUBGCP5,NEDD1,PKMYT1,CEP76,CDC25C,CDK1,YWHAG,OPTN,NUMA1,XPO1,RPS27A,PPP1CB,ALMS1,TUBB,LIN37,DCTN3,DYNC1I2,PPP1R12A,CDK11B,HAUS2,CKAP5,CEP57,CEP290,CENPJ,TUBGCP6,NEK2,HSP90AA1,UBB,CDC25A,CDK5RAP2,MYBL2,CEP131,BORA,UBC,MNAT1,PCM1,ODF2,SDCCAG8,OFD1,AURKA,PPP1R12B,NDE1,CEP192,CCNB2,LIN52
R-HSA-5696398	Nucleotide Excision Repair	7.5027474631042e-07	-14.102826369084	109	67	0.0212968849332486	3146	8202	2033,2071,54617,8450,404672,5424,5886,5111,51138,5887,54778,79913,6917,9716,5984,2067,5983,1161,7311,5436,5441,9978,10450,5433,5982,85015,10401,5432,50813,7336,2074,6233,2073,60,5981,10980,83444,7334,57461,5440,7508,3978,2072,3980,7341,8178,8533,64708,125476,2068,7314,1643,3150,5438,10445,9318,10714,5430,7316,4331,5427,5426,5434,91603,7528,1642,5425	EP300,ERCC3,INO80,CUL4B,GTF2H5,POLD1,RAD23A,PCNA,COPS4,RAD23B,RNF111,ACTR5,TCEA1,AQR,RFC4,ERCC1,RFC3,ERCC8,UBA52,POLR2G,POLR2L,RBX1,PPIE,POLR2D,RFC2,USP45,PIAS3,POLR2C,COPS7A,UBE2V2,ERCC6,RPS27A,ERCC5,ACTB,RFC1,COPS6,INO80B,UBE2N,ISY1,POLR2K,XPC,LIG1,ERCC4,LIG3,SUMO1,ELL,COPS3,COPS7B,INO80C,ERCC2,UBB,DDB2,HMGN1,POLR2I,MCRS1,COPS2,POLD3,POLR2A,UBC,MNAT1,POLE2,POLE,POLR2E,ZNF830,YY1,DDB1,POLD2
R-HSA-73857	RNA Polymerase II Transcription	7.56647656647732e-07	-14.0943681388277	107	66	0.020979020979021	3146	8202	65109,2071,134353,10978,6636,6635,404672,53981,6427,29894,25888,6429,6882,6917,84967,25920,6881,6877,5436,5441,6923,8731,5433,10921,7884,51585,6873,5432,905,6827,11051,7307,6637,6749,51497,6884,9150,51362,6908,6872,5440,10250,102157402,2962,8178,83860,2963,2068,2959,9295,5438,1479,7936,6921,6430,6829,6875,5430,4331,2957,5434,1478,22916,6428,6883,6878	UPF3B,ERCC3,LSM11,CLP1,SNRPF,SNRPE,GTF2H5,CPSF2,SRSF2,CPSF1,ZNF473,SRSF4,TAF11,TCEA1,LSM10,NELFB,TAF10,TAF5,POLR2G,POLR2L,TCEB2,RNMT,POLR2D,RNPS1,SLBP,PCF11,TAF2,POLR2C,CCNT2,SUPT4H1,NUDT21,U2AF1,SNRPG,SSRP1,NELFCD,TAF13,CTDP1,CDC40,TBP,TAF1,POLR2K,SRRM1,AK6,GTF2F1,ELL,TAF3,GTF2F2,ERCC2,GTF2B,SRSF11,POLR2I,CSTF3,NELFE,TCEB1,SRSF5,SUPT5H,TAF4B,POLR2A,MNAT1,GTF2A1,POLR2E,CSTF2,NCBP2,SRSF3,TAF12,TAF6
R-HSA-1169091	Activation of NF-kappaB in B cells	8.08681859860743e-07	-14.0278602483306	66	45	0.0143038779402416	3146	8202	23291,5689,5693,5683,5966,5713,5716,8454,1147,5720,5715,9491,5708,5687,5696,5688,3551,5701,23198,10213,5717,7314,5970,5686,5694,7311,5692,5702,5695,10892,5710,5685,5691,7316,5704,5719,6233,5706,5709,5690,5705,9861,4793,5700,5711	FBXW11,PSMB1,PSMB5,PSMA2,REL,PSMD7,PSMD10,CUL1,CHUK,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,IKBKB,PSMC2,PSME4,PSMD14,PSMD11,UBB,RELA,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,MALT1,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,RPS27A,PSMC6,PSMD3,PSMB2,PSMC5,PSMD6,NFKBIB,PSMC1,PSMD5
R-HSA-5387390	Hh mutants abrogate ligand secretion	9.2562987132927e-07	-13.8927913891922	55	39	0.012396694214876	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,5708,5696,5687,5688,5701,23198,10213,5717,7314,5686,5694,7311,5692,5702,5695,84447,5710,5685,7316,5691,5704,5719,5706,51009,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMB8,PSMA6,PSMA7,PSMC2,PSME4,PSMD14,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,SYVN1,PSMD4,PSMA4,UBC,PSMB3,PSMC4,PSMD13,PSMC6,DERL2,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	9.2562987132927e-07	-13.8927913891922	55	39	0.012396694214876	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,5708,5696,5687,5688,5701,23198,10213,5717,7314,5686,5694,7311,5692,5702,5695,84447,5710,5685,7316,5691,5704,5719,5706,51009,6233,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMB8,PSMA6,PSMA7,PSMC2,PSME4,PSMD14,PSMD11,UBB,PSMA5,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,SYVN1,PSMD4,PSMA4,UBC,PSMB3,PSMC4,PSMD13,PSMC6,DERL2,RPS27A,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-392499	Metabolism of proteins	1.19519055236348e-06	-13.6372049272481	943	429	0.136363636363636	3146	8202	3015,23511,118,1801,5589,5611,1964,8350,8365,6147,6484,6217,6134,8366,9695,29928,6194,55770,9972,8665,6227,10342,29843,81929,6731,6133,7311,10026,7039,63917,26503,51809,8661,5372,6165,291,6233,6208,197370,9045,6747,6188,83752,8704,1725,64061,26088,6480,79087,54344,6748,5073,129401,134266,4000,7057,811,8818,6137,966,23016,9126,1603,51564,81876,54872,56005,4801,79902,26986,22870,1936,6228,56052,5279,2673,1984,6154,9512,23404,10274,54543,30001,1974,6204,6746,5393,256435,4580,10452,7458,10640,56160,22872,6726,2677,6158,1678,6730,9063,8892,85365,55291,6727,1029,8354,10383,9451,348995,6015,440,6996,6464,6672,8364,56915,22845,57122,9488,51121,84261,55650,79796,10484,10576,23256,2931,8669,150274,6169,467,6232,5861,6901,27230,6622,27335,26234,6950,1650,29927,51009,286053,51025,7466,1967,3014,8243,6176,6173,440138,6224,51588,6396,284098,6187,7508,10825,23621,10905,8604,2923,567,506,641,1915,9883,5281,7341,121504,6139,4245,1075,79868,51227,23203,6143,22803,54512,51360,10678,375056,56648,6132,6129,5045,131474,29071,10525,51693,10427,10897,51128,84752,8334,6136,1802,1968,199857,9797,7494,4802,8570,439,6152,1649,116138,10564,3068,170689,4240,7841,1798,120526,55757,3646,10055,8358,9919,9487,148867,6745,1499,25813,81562,8733,6168,146712,6222,1983,374378,23471,1977,8331,10159,55176,8352,7709,83475,118460,468,8813,6230,80273,25870,672,84720,4736,10610,29926,10469,4122,10195,2934,1981,26517,2627,2081,4253,60,55568,8720,6231,6209,9871,51010,26272,79053,6138,10652,8702,54507,7270,80055,6125,23165,56913,9349,1938,6205,55676,6904,149371,6729,56993,9114,6811,5029,10113,516,8968,83696,80267,10282,84447,8368,122553,3801,197257,9709,6934,25873,6130,10063,27095,60412,9554,23636,493861,498,8775,9945,4351,9804,64841,6181,6235,5283,26984,6193,6156,821,9656,10471,9117,26520,6218,6135,22948,1200,56605,10054,1431,84733,8693,3998,10130,205564,10106,144245,6207,3486,10802,6499,11224,6734,7411,10735,6142,9631,55741,131118,7416,8021,8666,6203,2671,91869,6487,8667,3921,401505,8294,79947,5903,50,8351,1978,10440,9314,29925,8662,8338,6146,3020,6482,8535,6202,6122,7280,7109,8367,8480,7095,10020,8877,79677,285362,56886,23265,23062,11231,1155,5373,6728,8360,6164,3799,6234,9632,6155,5238,653604,8345,3329,10381,9868,9761,2626,6171,22955,7203,1294,9669,8357,6175,5201,6189,2517,7175,94027,3012,6210,63908,1965,2720,6206,6124,79090	H2AFZ,NUP188,ADD1,DPH1,PRKCSH,DNAJC3,EIF1AX,HIST1H3A,HIST1H4H,RPL23A,ST3GAL4,RPS16,RPL10,HIST1H4B,EDEM1,TIMM22,RPS6,EXOC2,NUP153,EIF3F,RPS21,TFG,SENP1,SEH1L,SRP72,RPL9,UBA52,PIGK,TGFA,GALNT11,SLC17A5,GALNT7,EIF3A,PMM1,RPL35A,SLC25A4,RPS27A,RPS14,NSMCE1,RPL14,SSR3,RPS3,LONP2,B4GALT2,DHPS,TSPYL2,GGA1,ST6GAL1,ALG12,DPM3,SSR4,PARN,NUP35,GRPEL2,LMNA,THBS1,CALR,DPM2,RPL13,CD59,EXOSC7,SMC3,DAD1,HDAC7,RAB1B,PIGG,MYDGF,NFYB,NUP85,PABPC1,PPP6R1,EEF1D,RPS23,ALG1,PIGC,GFPT1,EIF5A,RPL26,PMPCB,EXOSC2,STAG1,TOMM7,ERO1A,EIF4A2,RPS10,SSR2,EXOSC9,ST6GALNAC3,MTX1,TOMM40,EIF4H,EXOC5,NDNL2,SEC31A,SRP9,GGCX,RPL28,TIMM8A,SRP68,PIAS2,EIF2B2,ALG2,PPP6R3,SRP14,CDKN2A,HIST1H3I,TUBB4B,EIF2AK3,NUP43,RING1,ASNS,TDG,SHC1,SP100,HIST1H4C,EXOSC5,DOLK,NUP107,PIGB,RPL26L1,FBXW9,PIGV,ALG9,SEC23A,CCT2,SCFD1,GSK3A,EIF3J,HSCB,RPL38,ATF3,RPS27,RAB1A,TAZ,SERP1,SNCA,EIF3K,FBXL5,TCP1,DDOST,SEC61A1,DERL2,NSMCE2,PAM16,WFS1,EIF2B1,H2AFX,SMC1A,RPLP1,RPL36A,ALG11,RPS20,PIAS4,SEC13,PIGW,RPS2,XPC,NEU3,BACE1,MAN1A2,SLC25A12,PDIA3,B2M,ATP5B,BLM,EEF1A1,POM121,PIGF,SUMO1,HIST4H4,RPL17,MGAT1,CTSC,ALG13,PIGP,PMPCA,RPL19,XRN2,EXOSC4,MBTPS2,B3GNT2,MIA3,EIF5A2,RPL8,RPL7,FURIN,CHCHD4,C1GALT1C1,HYOU1,TRAPPC2L,SEC24B,YIF1A,SAR1B,B3GNT9,HIST1H2AC,RPL12,DPH2,EIF2S3,ALG14,TATDN2,XBP1,NFYC,KHSRP,ASNA1,RPL24,DDIT3,KLHDC3,ARFGEF2,HDGF,ADAMTS15,MFGE8,MOGS,DPAGT1,DNAJC24,UGGT2,EIF3E,SAE1,HIST1H3B,SEC16A,PIGL,SLC30A7,SSR1,CTNNB1,SAMM50,LMAN2L,GPAA1,RPL37A,B3GNTL1,RPS18,EIF5,GALNT18,TRAM1,EIF4E,HIST1H2AJ,ATP6AP2,SEC61A2,HIST1H3C,ZBTB17,DOHH,EXOSC6,ATF4,DPM1,RPS25,GRPEL1,SUMF2,BRCA1,PIGO,RPL10A,ST6GALNAC2,GMPPA,TIMM44,MAN2A2,ALG3,GSN,EIF4G1,TIMM13,GATA6,ERN1,CTAGE5,ACTB,GALNT10,MBTPS1,RPS26,RPS15,SEC24D,EXOSC3,FBXO4,ALG8,RPL15,YKT6,B4GALT4,ADAMTSL4,TTF1,PGAP1,RPL5,NUP205,C1GALT1,RPL23,EEF2,RPS11,SLC30A6,TBCD,EXOC8,SRP54,TOMM22,ATP6V0D1,STX5,P2RY2,PREB,ATP5G1,HIST1H3F,TRAPPC9,EDEM3,BET1,SYVN1,HIST1H4L,TRAPPC6B,KIFC3,LDHD,HERPUD1,TCF7L2,RPL36,RPL7A,COX17,TRAPPC3,EXOC4,SEC22B,NUP62,EID3,ATP5A1,NAPA,GFPT2,MPI,TOMM20,GNPNAT1,RPLP2,RPS29,PIGH,SEC22A,RPS5,RPL30,CANX,MDC1,PFDN6,SEC22C,TIMM9,RPS17,RPL11,CCT5,TPP1,ERO1B,UBA2,CS,CBX2,GALNT4,LMAN1,PDIA6,SENP5,CTDSP2,ALG10B,RPS13,IGFBP3,SEC24A,SKIV2L,RPL35,SRPR,VBP1,STAG2,RPL18A,NUP155,EDEM2,DNAJC19,VDAC1,NUP214,EIF3G,RPS9,GFER,RFT1,ST3GAL3,EIF3H,RPSA,TOMM5,HIST1H4I,DHDDS,RANBP2,ACO2,HIST1H3D,EIF4EBP1,TIMM17A,KLF4,GMPPB,EIF3B,HIST2H2AC,RPL22,H3F3A,ST3GAL1,CBX4,RPS8,RPL3,TUBB2A,TRAPPC10,HIST1H4E,RAE1,SEC62,GNE,SPHK1,SMC6,SUMF1,UGGT1,EXOC7,GGA2,SEC63,TBCB,PMM2,SRP19,HIST1H4D,RPL34,KIF5B,RPS28,SEC24C,RPL27,PGM3,HIST2H3D,HIST1H2BH,HSPD1,TUBB3,TOMM70A,MLEC,GATA4,RPL41,SCMH1,CCT3,COL7A1,EIF5B,HIST1H3H,RPLP0,PFDN1,RPS3A,FUCA1,TPR,CGB7,HIST1H2AE,RPS15A,NAPB,EIF2S1,GLB1,RPS12,RPL4,TRAPPC6A
R-HSA-5687128	MAPK6/MAPK4 signaling	1.23900590861631e-06	-13.6012011864696	88	56	0.0178003814367451	3146	8202	23112,5689,5693,5683,5879,5713,5716,5720,3337,5566,5715,2309,9491,5708,5687,5696,8555,5688,5062,5701,896,10213,23198,5717,7314,2118,5686,5567,5694,7311,5692,5702,8550,5695,989,5710,983,5685,5691,7316,5704,8202,7514,5719,5706,6233,5709,5597,5690,9861,5705,4343,8556,5700,5711,192669	TNRC6B,PSMB1,PSMB5,PSMA2,RAC1,PSMD7,PSMD10,PSME1,DNAJB1,PRKACA,PSMD9,FOXO3,PSMF1,PSMD2,PSMA6,PSMB8,CDC14B,PSMA7,PAK2,PSMC2,CCND3,PSMD14,PSME4,PSMD11,UBB,ETV4,PSMA5,PRKACB,PSMB6,UBA52,PSMB4,PSMC3,MAPKAPK5,PSMB7,SEPT7,PSMD4,CDK1,PSMA4,PSMB3,UBC,PSMC4,NCOA3,XPO1,PSMD13,PSMC6,RPS27A,PSMD3,MAPK6,PSMB2,PSMD6,PSMC5,MOV10,CDC14A,PSMC1,PSMD5,AGO3
R-HSA-5621481	C-type lectin receptors (CLRs)	1.65852911058452e-06	-13.3095794263561	123	73	0.0232040686586141	3146	8202	2033,23291,5683,5894,8454,1147,5720,3709,5566,4067,1387,5696,5687,5688,3551,5701,23198,10213,4791,841,7321,10768,5970,5567,7311,5695,7335,3710,2534,5719,23118,5706,6233,5709,5690,5705,9861,10454,5700,7334,5711,5689,5693,257397,9039,5713,808,5716,5532,5715,9252,9491,5708,5062,5717,7314,9020,5686,5694,5170,5692,5702,10892,5710,5685,7316,5691,5704,997,3708,7322,5534,3265	EP300,FBXW11,PSMA2,RAF1,CUL1,CHUK,PSME1,ITPR2,PRKACA,LYN,CREBBP,PSMB8,PSMA6,PSMA7,IKBKB,PSMC2,PSME4,PSMD14,NFKB2,CASP8,UBE2D1,AHCYL1,RELA,PRKACB,UBA52,PSMB7,UBE2V1,ITPR3,FYN,PSMD13,TAB2,PSMC6,RPS27A,PSMD3,PSMB2,PSMC5,PSMD6,TAB1,PSMC1,UBE2N,PSMD5,PSMB1,PSMB5,TAB3,UBA3,PSMD7,CALM3,PSMD10,PPP3CB,PSMD9,RPS6KA5,PSMF1,PSMD2,PAK2,PSMD11,UBB,MAP3K14,PSMA5,PSMB6,PDPK1,PSMB4,PSMC3,MALT1,PSMD4,PSMA4,UBC,PSMB3,PSMC4,CDC34,ITPR1,UBE2D2,PPP3R1,HRAS
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	1.91443383804071e-06	-13.1660886249753	77	50	0.0158931977113795	3146	8202	2033,5440,57461,2071,8450,3978,2072,3980,404672,5424,8178,5111,51138,8533,64708,6917,2068,9716,7314,2067,5984,3150,1161,5438,7311,5983,9318,5436,5441,9978,10450,5433,10714,5982,5430,7316,5432,4331,5426,50813,5427,2074,6233,5434,2073,5981,10980,91603,1642,5425	EP300,POLR2K,ISY1,ERCC3,CUL4B,LIG1,ERCC4,LIG3,GTF2H5,POLD1,ELL,PCNA,COPS4,COPS3,COPS7B,TCEA1,ERCC2,AQR,UBB,ERCC1,RFC4,HMGN1,ERCC8,POLR2I,UBA52,RFC3,COPS2,POLR2G,POLR2L,RBX1,PPIE,POLR2D,POLD3,RFC2,POLR2A,UBC,POLR2C,MNAT1,POLE,COPS7A,POLE2,ERCC6,RPS27A,POLR2E,ERCC5,RFC1,COPS6,ZNF830,DDB1,POLD2
R-HSA-201681	TCF dependent signaling in response to WNT	2.41998153002314e-06	-12.9317506500466	229	122	0.0387794024157661	3146	8202	2033,3015,55366,5683,6597,10524,324,8358,8350,5720,2535,8658,5519,7474,8365,1387,5696,5687,1499,8366,57680,5688,8364,5701,10213,23198,9070,1856,8331,8321,9736,8352,7311,79412,207,9978,8322,123169,208,1454,5695,8452,23401,1857,25776,857,26108,6659,80319,8294,5529,7514,5719,5706,6233,8351,5709,3014,3065,2932,5527,5690,3020,8338,5705,9861,5700,5528,5711,5689,5693,8367,8325,6662,5713,5716,84133,90780,1452,5715,5929,9491,8360,121504,56998,5708,283149,4040,653604,5717,8345,7314,5686,5694,7091,8968,5692,7090,5702,139285,9101,64750,5710,4221,8368,8357,5685,5691,7316,6934,5704,22943,9580,3012,8334,10023,6259,7534,7855,1487,81847,8354	EP300,H2AFZ,LGR4,PSMA2,SMARCA4,KAT5,APC,HIST1H3B,HIST1H3A,PSME1,FZD2,TNKS,PPP2R1B,WNT5A,HIST1H4H,CREBBP,PSMB8,PSMA6,CTNNB1,HIST1H4B,CHD8,PSMA7,HIST1H4C,PSMC2,PSMD14,PSME4,ASH2L,DVL2,HIST1H2AJ,FZD1,USP34,HIST1H3C,UBA52,KREMEN2,AKT1,RBX1,FZD4,LEO1,AKT2,CSNK1E,PSMB7,CUL3,FRAT2,DVL3,CBY1,CAV1,PYGO1,SOX4,CXXC4,HIST1H4I,PPP2R5E,XPO1,PSMD13,PSMC6,RPS27A,HIST1H3D,PSMD3,H2AFX,HDAC1,GSK3B,PPP2R5C,PSMB2,H3F3A,HIST2H2AC,PSMC5,PSMD6,PSMC1,PPP2R5D,PSMD5,PSMB1,PSMB5,HIST1H4E,FZD8,SOX9,PSMD7,PSMD10,ZNRF3,PYGO2,CSNK1A1,PSMD9,RBBP5,PSMF1,HIST1H4D,HIST4H4,CTNNBIP1,PSMD2,BCL9L,LRP6,HIST2H3D,PSMD11,HIST1H2BH,UBB,PSMA5,PSMB6,TLE4,HIST1H3F,PSMB4,TLE3,PSMC3,AMER1,USP8,SMURF2,PSMD4,MEN1,HIST1H4L,HIST1H3H,PSMA4,PSMB3,UBC,TCF7L2,PSMC4,DKK1,SOX13,HIST1H2AE,HIST1H2AC,FRAT1,RYK,YWHAZ,FZD5,CTBP1,RNF146,HIST1H3I
R-HSA-5358346	Hedgehog ligand biogenesis	2.61133428260742e-06	-12.855649247868	64	43	0.0136681500317864	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,5708,5687,5696,5034,5688,5701,10213,23198,5717,7314,5686,5694,6868,7311,5692,5702,5695,84447,5710,5685,5691,7316,5704,5719,5706,51009,6233,5709,55733,5690,85455,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,P4HB,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,UBB,PSMA5,PSMB6,ADAM17,UBA52,PSMB4,PSMC3,PSMB7,SYVN1,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,DERL2,RPS27A,PSMD3,HHAT,PSMB2,DISP2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-199991	Membrane Trafficking	2.74344940353496e-06	-12.8062945229229	256	134	0.0425937698664971	3146	8202	51552,8218,5565,8673,7531,9919,81567,4218,57148,81562,8907,1785,55770,10342,7311,208,8905,7039,10717,5571,8546,51028,5898,6233,1213,4253,7251,27183,2580,92421,9871,11267,808,7082,10652,9685,84313,4641,9276,966,4952,81876,149371,22870,10113,6811,3482,2512,83696,23433,54885,10282,9179,55048,122553,55330,10640,22872,27095,51422,8773,60412,11127,9554,7534,55291,8775,388552,5878,2810,6517,51510,11316,5879,26984,2495,25977,8729,9117,79058,2707,8906,3998,1315,10802,1362,10484,207,23256,9525,10971,7163,25978,5861,23431,10890,7532,10052,22820,27131,6396,1173,6272,7109,375,23265,7164,8766,7037,1075,9632,375519,57186,130340,7314,4646,11154,6643,5872,375056,1294,6810,26258,8301,7316,51693,51128,10427,63908,9882,7533,79090,164,23557	RAB14,CLTCL1,PRKAB2,VAMP8,YWHAE,SEC16A,TXNDC5,RAB8A,RALGAPB,LMAN2L,AP1M1,DNM2,EXOC2,TFG,UBA52,AKT2,AP1S2,TGFA,AP4B1,PRKAG1,AP3B1,VPS36,RALA,RPS27A,CLTC,CTAGE5,TSG101,VPS4A,GAK,CHMP4C,SEC24D,SNF8,CALM3,TJP1,YKT6,CLINT1,VPS25,MYO1C,COPB2,CD59,OCRL,RAB1B,EXOC8,PPP6R1,PREB,STX5,IGF2R,FTL,TRAPPC9,RHOQ,TBC1D8B,BET1,AP4M1,VPS37C,TRAPPC6B,BLOC1S4,EXOC5,SEC31A,TRAPPC3,PRKAG2,SNAP23,EXOC4,KIF3A,SEC22B,YWHAZ,PPP6R3,NAPA,BLOC1S3,RAB5C,SFN,SLC2A4,CHMP5,COPE,RAC1,SEC22A,FTH1,NECAP1,GBF1,SEC22C,ASPSCR1,GJB3,AP1G2,LMAN1,COPB1,SEC24A,CPD,SEC23A,AKT1,SCFD1,VPS4B,YWHAQ,TPD52,CHMP2B,RAB1A,AP4E1,RAB10,YWHAG,GJC1,COPG1,SNX5,SEC13,AP2M1,SORT1,TRAPPC10,ARF1,EXOC7,TPD52L1,RAB11A,TFRC,CTSC,SEC24C,GJB7,RALGAPA2,AP1S3,UBB,MYO6,AP4S1,SNX2,RAB13,MIA3,COL7A1,STX4,BLOC1S6,PICALM,UBC,TRAPPC2L,SAR1B,SEC24B,NAPB,TBC1D4,YWHAH,TRAPPC6A,AP1G1,SNAPIN
R-HSA-5663220	RHO GTPases Activate Formins	2.9169588966769e-06	-12.7449689581355	114	68	0.0216147488874762	3146	8202	57405,71,5048,5879,11004,348995,81624,5519,79003,9183,25909,57122,8379,1856,81929,81565,1058,348235,991,1857,6232,64105,9212,79682,3796,5903,5529,7514,79980,25936,4085,3688,6722,5527,60,23122,151648,5528,6396,389,54821,5217,5501,9793,55920,151246,55166,699,9735,79019,114793,79902,10726,387,11130,5905,220134,1729,388,401541,6249,81930,23421,147841,286205,57082,54820,3619	SPC25,ACTG1,PAFAH1B1,RAC1,KIF2C,NUP43,DIAPH3,PPP2R1B,MIS12,ZW10,AHCTF1,NUP107,MAD1L1,DVL2,SEH1L,NDEL1,CENPA,SKA2,CDC20,DVL3,RPS27,CENPK,AURKB,CENPU,KIF2A,RANBP2,PPP2R5E,XPO1,DSN1,NSL1,MAD2L1,ITGB1,SRF,PPP2R5C,ACTB,CLASP2,SGOL1,PPP2R5D,SEC13,RHOC,ERCC6L,PFN2,PPP1CC,CKAP5,RCC2,SGOL2,CENPQ,BUB1,KNTC1,CENPM,FMNL2,NUP85,NUDC,RHOA,ZWINT,RANGAP1,SKA1,DIAPH1,RHOB,CENPP,CLIP1,KIF18A,ITGB3BP,SPC24,SCAI,CASC5,NDE1,INCENP
R-HSA-68877	Mitotic Prometaphase	3.12661807872018e-06	-12.6755586235899	108	65	0.0206611570247934	3146	8202	57405,5048,11004,348995,891,5519,79003,9183,25909,57122,8379,81929,81565,1058,348235,991,10735,6232,64105,9212,10592,983,79682,3796,5903,5529,7514,79980,25936,4085,8243,5527,23122,151648,5528,6396,54821,5501,9793,9126,55920,151246,55166,699,79019,9735,79902,10726,10051,11130,10274,5905,220134,401541,23244,6249,81930,23421,23063,113130,147841,57082,54820,9133,3619	SPC25,PAFAH1B1,KIF2C,NUP43,CCNB1,PPP2R1B,MIS12,ZW10,AHCTF1,NUP107,MAD1L1,SEH1L,NDEL1,CENPA,SKA2,CDC20,STAG2,RPS27,CENPK,AURKB,SMC2,CDK1,CENPU,KIF2A,RANBP2,PPP2R5E,XPO1,DSN1,NSL1,MAD2L1,SMC1A,PPP2R5C,CLASP2,SGOL1,PPP2R5D,SEC13,ERCC6L,PPP1CC,CKAP5,SMC3,RCC2,SGOL2,CENPQ,BUB1,CENPM,KNTC1,NUP85,NUDC,SMC4,ZWINT,STAG1,RANGAP1,SKA1,CENPP,PDS5A,CLIP1,KIF18A,ITGB3BP,WAPL,CDCA5,SPC24,CASC5,NDE1,CCNB2,INCENP
R-HSA-5632684	Hedgehog 'on' state	3.48078824284108e-06	-12.5682517832631	84	53	0.0168467895740623	3146	8202	5689,5693,5683,5713,5716,5720,1452,5715,9491,2619,2622,5708,2737,22873,5687,5696,23288,5688,5701,10213,23198,5717,339745,7314,5686,5694,7311,5692,9978,83737,5702,8452,5695,5727,64750,5710,5685,5691,7316,5704,5719,5706,6233,5709,11127,5690,9861,5705,409,57154,5700,5711,8650	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,CSNK1A1,PSMD9,PSMF1,GAS1,GAS8,PSMD2,GLI3,DZIP1,PSMA6,PSMB8,IQCE,PSMA7,PSMC2,PSMD14,PSME4,PSMD11,SPOPL,UBB,PSMA5,PSMB6,UBA52,PSMB4,RBX1,ITCH,PSMC3,CUL3,PSMB7,PTCH1,SMURF2,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,PSMC6,RPS27A,PSMD3,KIF3A,PSMB2,PSMD6,PSMC5,ARRB2,SMURF1,PSMC1,PSMD5,NUMB
R-HSA-381119	Unfolded Protein Response (UPR)	3.49797799485169e-06	-12.5633254721676	86	54	0.0171646535282899	3146	8202	3068,118,51010,64061,5611,7095,9451,11231,5073,4000,6745,811,1200,440,23016,6464,9695,56915,54512,56005,10130,9114,4801,10106,51360,10113,55176,7709,2673,23404,118460,468,6734,2931,10525,467,5393,84447,27230,9709,10897,22872,29927,9797,7466,7494,2081,4802,8570,1965,439,8720,1649,116138	HDGF,ADD1,EXOSC3,TSPYL2,DNAJC3,SEC62,EIF2AK3,SEC63,PARN,LMNA,SSR1,CALR,TPP1,ASNS,EXOSC7,SHC1,EDEM1,EXOSC5,EXOSC4,MYDGF,PDIA6,ATP6V0D1,NFYB,CTDSP2,MBTPS2,PREB,SEC61A2,ZBTB17,GFPT1,EXOSC2,EXOSC6,ATF4,SRPR,GSK3A,HYOU1,ATF3,EXOSC9,SYVN1,SERP1,HERPUD1,YIF1A,SEC31A,SEC61A1,TATDN2,WFS1,XBP1,ERN1,NFYC,KHSRP,EIF2S1,ASNA1,MBTPS1,DDIT3,KLHDC3
R-HSA-504046	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	5.72997535213634e-06	-12.0697993287938	145	82	0.0260648442466624	3146	8202	57504,3015,2071,8358,8350,404672,51728,8365,54700,8366,10849,8364,1108,55703,30834,8331,8352,2975,5441,4774,5451,6618,53615,7343,8294,2074,1107,8351,3014,27297,3065,6619,2972,6741,3020,8338,3066,6617,7978,6908,8367,5440,171568,2971,7702,7270,8360,121504,54815,9014,8932,653604,8345,84172,2068,64425,10302,10621,8968,2976,57459,5931,2648,79101,9328,9219,55814,84265,8368,8357,4781,11128,221830,5595,4331,3012,8334,5434,9329,4782,9533,8354	MTA3,H2AFZ,ERCC3,HIST1H3B,HIST1H3A,GTF2H5,POLR3K,HIST1H4H,RRN3,HIST1H4B,CD3EAP,HIST1H4C,CHD4,POLR3B,ZNRD1,HIST1H2AJ,HIST1H3C,GTF3C1,POLR2L,NFIA,POU2F1,SNAPC2,MBD3,UBTF,HIST1H4I,ERCC6,CHD3,HIST1H3D,H2AFX,CRCP,HDAC1,SNAPC3,BRF1,SSB,H3F3A,HIST2H2AC,HDAC2,SNAPC1,MTERF1,TBP,HIST1H4E,POLR2K,POLR3H,GTF3A,ZNF143,TTF1,HIST1H4D,HIST4H4,GATAD2A,TAF1B,MBD2,HIST2H3D,HIST1H2BH,POLR1B,ERCC2,POLR1E,SNAPC5,POLR3F,HIST1H3F,GTF3C2,GATAD2B,RBBP7,KAT2A,TAF1D,GTF3C5,MTA2,BDP1,POLR3GL,HIST1H4L,HIST1H3H,NFIB,POLR3A,TWISTNB,MAPK3,MNAT1,HIST1H2AE,HIST1H2AC,POLR2E,GTF3C4,NFIC,POLR1C,HIST1H3I
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	5.79986645041384e-06	-12.0576756664677	81	51	0.0162110616656071	3146	8202	11258,23291,1781,10142,11116,5116,80321,4659,10383,5048,8655,8454,7531,891,5566,55142,9793,9702,4218,80184,55835,84131,10733,4751,3320,80254,7314,7311,1454,55755,121441,79959,22994,79866,983,7316,7532,10133,5108,6233,4957,10806,8481,5500,4660,6790,54820,55125,9133,7840,203068	DCTN3,FBXW11,DYNC1I2,AKAP9,FGFR1OP,PCNT,CEP70,PPP1R12A,TUBB4B,PAFAH1B1,DYNLL1,CUL1,YWHAE,CCNB1,PRKACA,HAUS2,CKAP5,CEP57,RAB8A,CEP290,CENPJ,CEP78,PLK4,NEK2,HSP90AA1,CEP63,UBB,UBA52,CSNK1E,CDK5RAP2,NEDD1,CEP76,CEP131,BORA,CDK1,UBC,YWHAG,OPTN,PCM1,RPS27A,ODF2,SDCCAG8,OFD1,PPP1CB,PPP1R12B,AURKA,NDE1,CEP192,CCNB2,ALMS1,TUBB
R-HSA-3214847	HATs acetylate histones	5.99506781680859e-06	-12.0245734573205	143	81	0.0257469802924348	3146	8202	2033,10524,8358,8350,85235,9643,64769,440689,8365,79595,1387,284058,8366,8364,1386,6871,8331,84148,3054,8352,6881,7862,26009,56943,51147,55578,23326,79960,8294,8089,339287,55250,8351,8473,60,9575,8338,55689,8367,102157402,9913,8518,11091,8969,8360,80314,121504,55257,23587,6944,653604,54934,8345,8520,92815,8968,8336,55929,10445,55167,5931,2648,55140,8368,8357,55683,23338,8330,8464,51562,3012,54859,8334,84289,23522,10943,10856,6883,112869,8354,7994	EP300,KAT5,HIST1H3B,HIST1H3A,HIST1H2AH,MORF4L2,MEAF6,HIST2H2BF,HIST1H4H,SAP130,CREBBP,KANSL1,HIST1H4B,HIST1H4C,ATF2,TADA2A,HIST1H2AJ,KAT8,HCFC1,HIST1H3C,TAF10,BRPF1,ZZZ3,ENY2,ING4,SUPT20H,USP22,JADE1,HIST1H4I,YEATS4,MSL1,ELP2,HIST1H3D,OGT,ACTB,CLOCK,HIST2H2AC,YEATS2,HIST1H4E,AK6,SUPT7L,IKBKAP,WDR5,HIST1H2AG,HIST1H4D,EPC1,HIST4H4,MRGBP,ELP5,VPS72,HIST2H3D,KANSL2,HIST1H2BH,HAT1,HIST3H2A,HIST1H3F,HIST1H2AM,DMAP1,MCRS1,MSL2,RBBP7,KAT2A,ELP3,HIST1H4L,HIST1H3H,KANSL3,JADE2,HIST1H2AK,SUPT3H,MBIP,HIST1H2AE,ELP6,HIST1H2AC,ING5,KAT6B,MSL3,RUVBL2,TAF12,SGF29,HIST1H3I,KAT6A
R-HSA-170834	Signaling by TGF-beta Receptor Complex	9.40872240681789e-06	-11.573873383317	72	46	0.0146217418944692	3146	8202	7323,1030,1875,50848,5501,9372,22938,9110,51377,3726,54778,5494,5499,7314,7321,11171,6667,7050,387,7311,1024,5045,64750,4221,8239,7316,4088,51592,10273,905,7514,4087,25805,6233,23645,1874,25937,7027,5590,5500,3065,9611,7029,57154,4089,9958	UBE2D3,CDKN2B,E2F5,F11R,PPP1CC,ZFYVE9,SNW1,MTMR4,UCHL5,JUNB,RNF111,PPM1A,PPP1CA,UBB,UBE2D1,STRAP,SP1,TGIF1,RHOA,UBA52,CDK8,FURIN,SMURF2,MEN1,USP9X,UBC,SMAD3,TRIM33,STUB1,CCNT2,XPO1,SMAD2,BAMBI,RPS27A,PPP1R15A,E2F4,WWTR1,TFDP1,PRKCZ,PPP1CB,HDAC1,NCOR1,TFDP2,SMURF1,SMAD4,USP15
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	1.08460948062298e-05	-11.4317054684597	21	18	0.00572155117609663	3146	8202	51433,7311,991,29882,8697,891,983,7316,7324,64682,996,6233,51529,10393,51434,7321,7314,11065	ANAPC5,UBA52,CDC20,ANAPC2,CDC23,CCNB1,CDK1,UBC,UBE2E1,ANAPC1,CDC27,RPS27A,ANAPC11,ANAPC10,ANAPC7,UBE2D1,UBB,UBE2C
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	1.18014269355602e-05	-11.3472901070613	40	29	0.00921805467260013	3146	8202	2976,2975,5441,5440,9328,6908,171568,55814,4774,5451,84265,2971,7702,6618,4781,51728,11128,5434,9329,27297,4782,6619,2972,6741,55703,9533,10302,10621,6617	GTF3C2,GTF3C1,POLR2L,POLR2K,GTF3C5,TBP,POLR3H,BDP1,NFIA,POU2F1,POLR3GL,GTF3A,ZNF143,SNAPC2,NFIB,POLR3K,POLR3A,POLR2E,GTF3C4,CRCP,NFIC,SNAPC3,BRF1,SSB,POLR3B,POLR1C,SNAPC5,POLR3F,SNAPC1
R-HSA-74158	RNA Polymerase III Transcription	1.18014269355602e-05	-11.3472901070613	40	29	0.00921805467260013	3146	8202	2976,2975,5441,5440,9328,6908,171568,55814,4774,5451,84265,2971,7702,6618,4781,51728,11128,5434,9329,27297,4782,6619,2972,6741,55703,9533,10302,10621,6617	GTF3C2,GTF3C1,POLR2L,POLR2K,GTF3C5,TBP,POLR3H,BDP1,NFIA,POU2F1,POLR3GL,GTF3A,ZNF143,SNAPC2,NFIB,POLR3K,POLR3A,POLR2E,GTF3C4,CRCP,NFIC,SNAPC3,BRF1,SSB,POLR3B,POLR1C,SNAPC5,POLR3F,SNAPC1
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	1.31866083778266e-05	-11.2363087601738	57	38	0.0120788302606484	3146	8202	142678,2033,54567,102,8454,83933,10013,83464,57534,23493,1387,22938,182,51564,5664,9794,7314,55534,3280,6868,7311,1024,2648,51107,9978,8841,54492,10014,7316,9759,6233,10046,3065,6907,3516,9611,23385,3066	MIB2,EP300,DLL4,ADAM10,CUL1,HDAC10,HDAC6,APH1B,MIB1,HEY2,CREBBP,SNW1,JAG1,HDAC7,PSEN2,MAML1,UBB,MAML3,HES1,ADAM17,UBA52,CDK8,KAT2A,APH1A,RBX1,HDAC3,NEURL1B,HDAC5,UBC,HDAC4,RPS27A,MAMLD1,HDAC1,TBL1X,RBPJ,NCOR1,NCSTN,HDAC2
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	1.31866083778266e-05	-11.2363087601738	57	38	0.0120788302606484	3146	8202	142678,2033,54567,102,8454,83933,10013,83464,57534,23493,1387,22938,182,51564,5664,9794,7314,55534,3280,6868,7311,1024,2648,51107,9978,8841,54492,10014,7316,9759,6233,10046,3065,6907,3516,9611,23385,3066	MIB2,EP300,DLL4,ADAM10,CUL1,HDAC10,HDAC6,APH1B,MIB1,HEY2,CREBBP,SNW1,JAG1,HDAC7,PSEN2,MAML1,UBB,MAML3,HES1,ADAM17,UBA52,CDK8,KAT2A,APH1A,RBX1,HDAC3,NEURL1B,HDAC5,UBC,HDAC4,RPS27A,MAMLD1,HDAC1,TBL1X,RBPJ,NCOR1,NCSTN,HDAC2
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	1.31866083778266e-05	-11.2363087601738	57	38	0.0120788302606484	3146	8202	142678,2033,54567,102,8454,83933,10013,83464,57534,23493,1387,22938,182,51564,5664,9794,7314,55534,3280,6868,7311,1024,2648,51107,9978,8841,54492,10014,7316,9759,6233,10046,3065,6907,3516,9611,23385,3066	MIB2,EP300,DLL4,ADAM10,CUL1,HDAC10,HDAC6,APH1B,MIB1,HEY2,CREBBP,SNW1,JAG1,HDAC7,PSEN2,MAML1,UBB,MAML3,HES1,ADAM17,UBA52,CDK8,KAT2A,APH1A,RBX1,HDAC3,NEURL1B,HDAC5,UBC,HDAC4,RPS27A,MAMLD1,HDAC1,TBL1X,RBPJ,NCOR1,NCSTN,HDAC2
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	1.31866083778266e-05	-11.2363087601738	57	38	0.0120788302606484	3146	8202	142678,2033,54567,102,8454,83933,10013,83464,57534,23493,1387,22938,182,51564,5664,9794,7314,55534,3280,6868,7311,1024,2648,51107,9978,8841,54492,10014,7316,9759,6233,10046,3065,6907,3516,9611,23385,3066	MIB2,EP300,DLL4,ADAM10,CUL1,HDAC10,HDAC6,APH1B,MIB1,HEY2,CREBBP,SNW1,JAG1,HDAC7,PSEN2,MAML1,UBB,MAML3,HES1,ADAM17,UBA52,CDK8,KAT2A,APH1A,RBX1,HDAC3,NEURL1B,HDAC5,UBC,HDAC4,RPS27A,MAMLD1,HDAC1,TBL1X,RBPJ,NCOR1,NCSTN,HDAC2
R-HSA-2644603	Signaling by NOTCH1 in Cancer	1.31866083778266e-05	-11.2363087601738	57	38	0.0120788302606484	3146	8202	142678,2033,54567,102,8454,83933,10013,83464,57534,23493,1387,22938,182,51564,5664,9794,7314,55534,3280,6868,7311,1024,2648,51107,9978,8841,54492,10014,7316,9759,6233,10046,3065,6907,3516,9611,23385,3066	MIB2,EP300,DLL4,ADAM10,CUL1,HDAC10,HDAC6,APH1B,MIB1,HEY2,CREBBP,SNW1,JAG1,HDAC7,PSEN2,MAML1,UBB,MAML3,HES1,ADAM17,UBA52,CDK8,KAT2A,APH1A,RBX1,HDAC3,NEURL1B,HDAC5,UBC,HDAC4,RPS27A,MAMLD1,HDAC1,TBL1X,RBPJ,NCOR1,NCSTN,HDAC2
R-HSA-5610787	Hedgehog 'off' state	1.35794264976963e-05	-11.2069546681175	99	59	0.0187539732994278	3146	8202	5689,55081,5693,5683,54903,5713,8454,5716,26160,5720,1452,5566,5715,9491,5708,2737,5687,5696,5688,115,5701,10213,23198,5717,79659,7314,5686,5567,5694,7311,5692,51098,9978,83737,5702,5695,5727,5710,5685,5691,7316,5704,2778,5719,5706,6233,5709,7289,55764,57728,8481,11127,5690,2932,9861,5705,5700,5711,8650	PSMB1,IFT57,PSMB5,PSMA2,MKS1,PSMD7,CUL1,PSMD10,IFT172,PSME1,CSNK1A1,PRKACA,PSMD9,PSMF1,PSMD2,GLI3,PSMA6,PSMB8,PSMA7,ADCY9,PSMC2,PSMD14,PSME4,PSMD11,DYNC2H1,UBB,PSMA5,PRKACB,PSMB6,UBA52,PSMB4,IFT52,RBX1,ITCH,PSMC3,PSMB7,PTCH1,PSMD4,PSMA4,PSMB3,UBC,PSMC4,GNAS,PSMD13,PSMC6,RPS27A,PSMD3,TULP3,IFT122,WDR19,OFD1,KIF3A,PSMB2,GSK3B,PSMD6,PSMC5,PSMC1,PSMD5,NUMB
R-HSA-5617833	Assembly of the primary cilium	1.38223784668533e-05	-11.1892216511873	180	97	0.0308328035600763	3146	8202	10142,11116,261734,5116,79867,80321,5048,10383,8655,54903,26160,79738,89891,7531,10013,5566,8729,22948,9727,4218,5147,582,84131,10733,55770,80254,64792,10576,1454,129880,121441,79959,79600,983,7532,378,84100,28981,51668,6950,55764,26146,146057,7840,203068,3842,11258,1781,55081,585,23265,9321,27241,11020,8766,150737,55142,9793,403,9702,79598,85302,83657,80184,50807,55835,4751,149371,55112,79659,3320,27077,51098,55755,79969,7203,92104,117177,8195,80173,22994,57560,10640,166379,132320,5108,79989,4957,10806,57728,60412,8481,11127,6991,54820,55125,4867	AKAP9,FGFR1OP,NPHP4,PCNT,TCTN2,CEP70,PAFAH1B1,TUBB4B,DYNLL1,MKS1,IFT172,BBS10,WDR34,YWHAE,HDAC6,PRKACA,GBF1,CCT5,RAB11FIP3,RAB8A,PDE6D,BBS1,CEP78,PLK4,EXOC2,CEP63,IFT22,CCT2,CSNK1E,BBS5,NEDD1,CEP76,TCTN1,CDK1,YWHAG,ARF4,ARL6,IFT81,HSPB11,TCP1,IFT122,TRAF3IP1,TTBK2,ALMS1,TUBB,TNPO1,DCTN3,DYNC1I2,IFT57,BBS4,EXOC7,TRIP11,BBS9,IFT27,RAB11A,TTC30B,HAUS2,CKAP5,ARL3,CEP57,CEP97,FBF1,DYNLRB2,CEP290,ASAP1,CENPJ,NEK2,EXOC8,WDR60,DYNC2H1,HSP90AA1,B9D1,IFT52,CDK5RAP2,ATAT1,CCT3,TTC30A,RAB3IP,MKKS,IFT74,CEP131,IFT80,EXOC5,BBS12,SCLT1,PCM1,TTC26,ODF2,SDCCAG8,WDR19,EXOC4,OFD1,KIF3A,TCTE3,NDE1,CEP192,NPHP1
R-HSA-5628897	TP53 Regulates Metabolic Genes	1.60391193826263e-05	-11.0404798583656	73	46	0.0146217418944692	3146	8202	1329,51204,7249,2475,5565,5562,8649,64121,1327,7531,51241,10542,54541,57521,9997,143686,57103,1337,1349,285521,64223,7296,1350,207,208,1353,5571,10971,27244,6009,116228,7532,2744,51422,50484,2539,389541,9167,10128,10325,1351,7534,6341,7533,2810,58528	COX5B,TACO1,TSC2,MTOR,PRKAB2,PRKAA1,LAMTOR3,RRAGC,COX4I1,YWHAE,COX16,LAMTOR5,DDIT4,RPTOR,SCO2,SESN3,TIGAR,COX6A1,COX7B,COX18,MLST8,TXNRD1,COX7C,AKT1,AKT2,COX11,PRKAG1,YWHAQ,SESN1,RHEB,COX20,YWHAG,GLS,PRKAG2,RRM2B,G6PD,LAMTOR4,COX7A2L,LRPPRC,RRAGB,COX8A,YWHAZ,SCO1,YWHAH,SFN,RRAGD
R-HSA-3700989	Transcriptional Regulation by TP53	1.60391193826263e-05	-11.0404798583656	73	46	0.0146217418944692	3146	8202	1329,51204,7249,2475,5565,5562,8649,64121,1327,7531,51241,10542,54541,57521,9997,143686,57103,1337,1349,285521,64223,7296,1350,207,208,1353,5571,10971,27244,6009,116228,7532,2744,51422,50484,2539,389541,9167,10128,10325,1351,7534,6341,7533,2810,58528	COX5B,TACO1,TSC2,MTOR,PRKAB2,PRKAA1,LAMTOR3,RRAGC,COX4I1,YWHAE,COX16,LAMTOR5,DDIT4,RPTOR,SCO2,SESN3,TIGAR,COX6A1,COX7B,COX18,MLST8,TXNRD1,COX7C,AKT1,AKT2,COX11,PRKAG1,YWHAQ,SESN1,RHEB,COX20,YWHAG,GLS,PRKAG2,RRM2B,G6PD,LAMTOR4,COX7A2L,LRPPRC,RRAGB,COX8A,YWHAZ,SCO1,YWHAH,SFN,RRAGD
R-HSA-3214858	RMTs methylate histone arginines	1.60910619234161e-05	-11.0372466001685	75	47	0.0149396058486968	3146	8202	3015,8367,196528,3276,6597,8358,8350,85235,11091,8969,55170,57492,8360,8365,121504,8366,8364,653604,3717,10419,6605,8331,92815,10498,8968,8352,8336,6595,5931,6604,79084,8289,55193,8368,6601,8357,8330,8294,3012,8334,6599,8351,3014,54496,8338,8354,6602	H2AFZ,HIST1H4E,ARID2,PRMT1,SMARCA4,HIST1H3B,HIST1H3A,HIST1H2AH,WDR5,HIST1H2AG,PRMT6,ARID1B,HIST1H4D,HIST1H4H,HIST4H4,HIST1H4B,HIST1H4C,HIST2H3D,JAK2,PRMT5,SMARCE1,HIST1H2AJ,HIST3H2A,CARM1,HIST1H3F,HIST1H3C,HIST1H2AM,SMARCA2,RBBP7,SMARCD3,WDR77,ARID1A,PBRM1,HIST1H4L,SMARCC2,HIST1H3H,HIST1H2AK,HIST1H4I,HIST1H2AE,HIST1H2AC,SMARCC1,HIST1H3D,H2AFX,PRMT7,HIST2H2AC,HIST1H3I,SMARCD1
R-HSA-1268020	Mitochondrial protein import	2.10906234763907e-05	-10.7666820012557	52	35	0.0111252383979657	3146	8202	9804,8604,506,134266,26520,25813,29928,1431,23203,56993,3329,516,9868,9512,54543,80273,150274,131474,4580,131118,7416,10452,6901,197257,2671,401505,10469,10063,50,26517,291,1678,51025,10440,498	TOMM20,SLC25A12,ATP5B,GRPEL2,TIMM9,SAMM50,TIMM22,CS,PMPCA,TOMM22,HSPD1,ATP5G1,TOMM70A,PMPCB,TOMM7,GRPEL1,HSCB,CHCHD4,MTX1,DNAJC19,VDAC1,TOMM40,TAZ,LDHD,GFER,TOMM5,TIMM44,COX17,ACO2,TIMM13,SLC25A4,TIMM8A,PAM16,TIMM17A,ATP5A1
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	2.55654254583006e-05	-10.5742696873529	41	29	0.00921805467260013	3146	8202	80205,79071,6256,5465,2194,6604,7108,10654,9453,1387,4047,3422,3157,23054,4520,6721,2224,4802,6907,57678,1717,6309,5469,4801,10498,31,2222,6667,3156	CHD9,ELOVL6,RXRA,PPARA,FASN,SMARCD3,TM7SF2,PMVK,GGPS1,CREBBP,LSS,IDI1,HMGCS1,NCOA6,MTF1,SREBF2,FDPS,NFYC,TBL1X,GPAM,DHCR7,SC5D,MED1,NFYB,CARM1,ACACA,FDFT1,SP1,HMGCR
R-HSA-6782135	Dual incision in TC-NER	2.60133667752876e-05	-10.5569000453086	64	41	0.0130324221233312	3146	8202	2033,5440,57461,2071,8450,2072,404672,5424,5111,6917,2068,9716,7314,2067,5984,3150,1161,5438,7311,5983,5441,5436,9978,10450,5433,10714,5982,5430,7316,5432,4331,5426,5427,2074,6233,5434,2073,5981,91603,1642,5425	EP300,POLR2K,ISY1,ERCC3,CUL4B,ERCC4,GTF2H5,POLD1,PCNA,TCEA1,ERCC2,AQR,UBB,ERCC1,RFC4,HMGN1,ERCC8,POLR2I,UBA52,RFC3,POLR2L,POLR2G,RBX1,PPIE,POLR2D,POLD3,RFC2,POLR2A,UBC,POLR2C,MNAT1,POLE,POLE2,ERCC6,RPS27A,POLR2E,ERCC5,RFC1,ZNF830,DDB1,POLD2
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	2.67570883043069e-05	-10.5287111363856	70	44	0.013986013986014	3146	8202	23511,8480,8672,51191,3661,348995,5495,9883,23165,129401,5610,9246,9775,7706,57122,9972,7314,1977,79902,81929,3837,25820,4599,7311,3841,11274,1974,9631,1982,8021,9636,7316,7324,5595,7175,5903,1981,5335,3840,3839,6233,23636,3838,7334	NUP188,RAE1,EIF4G3,HERC5,IRF3,NUP43,PPM1B,POM121,NUP205,NUP35,EIF2AK2,UBE2L6,EIF4A3,TRIM25,NUP107,NUP153,UBB,EIF4E,NUP85,SEH1L,KPNB1,ARIH1,MX1,UBA52,KPNA5,USP18,EIF4A2,NUP155,EIF4G2,NUP214,ISG15,UBC,UBE2E1,MAPK3,TPR,RANBP2,EIF4G1,PLCG1,KPNA4,KPNA3,RPS27A,NUP62,KPNA2,UBE2N
R-HSA-1169408	ISG15 antiviral mechanism	2.67570883043069e-05	-10.5287111363856	70	44	0.013986013986014	3146	8202	23511,8480,8672,51191,3661,348995,5495,9883,23165,129401,5610,9246,9775,7706,57122,9972,7314,1977,79902,81929,3837,25820,4599,7311,3841,11274,1974,9631,1982,8021,9636,7316,7324,5595,7175,5903,1981,5335,3840,3839,6233,23636,3838,7334	NUP188,RAE1,EIF4G3,HERC5,IRF3,NUP43,PPM1B,POM121,NUP205,NUP35,EIF2AK2,UBE2L6,EIF4A3,TRIM25,NUP107,NUP153,UBB,EIF4E,NUP85,SEH1L,KPNB1,ARIH1,MX1,UBA52,KPNA5,USP18,EIF4A2,NUP155,EIF4G2,NUP214,ISG15,UBC,UBE2E1,MAPK3,TPR,RANBP2,EIF4G1,PLCG1,KPNA4,KPNA3,RPS27A,NUP62,KPNA2,UBE2N
R-HSA-1980143	Signaling by NOTCH1	2.67918657193979e-05	-10.5274122344513	72	45	0.0143038779402416	3146	8202	142678,2033,54567,102,8454,83933,10013,83464,57534,1387,23493,22938,182,51564,5664,9794,7314,55534,7091,3280,6868,7311,2648,1024,51107,9978,7090,83737,8841,54492,10014,7316,9759,3091,6233,10046,23220,3065,6907,9611,3516,409,23385,8650,3066	MIB2,EP300,DLL4,ADAM10,CUL1,HDAC10,HDAC6,APH1B,MIB1,CREBBP,HEY2,SNW1,JAG1,HDAC7,PSEN2,MAML1,UBB,MAML3,TLE4,HES1,ADAM17,UBA52,KAT2A,CDK8,APH1A,RBX1,TLE3,ITCH,HDAC3,NEURL1B,HDAC5,UBC,HDAC4,HIF1A,RPS27A,MAMLD1,DTX4,HDAC1,TBL1X,NCOR1,RBPJ,ARRB2,NCSTN,NUMB,HDAC2
R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	3.56365039953353e-05	-10.2421400523353	49	33	0.0104895104895105	3146	8202	5689,5693,5683,5713,5716,5720,5715,9491,5708,5687,5696,5688,5701,23198,10213,5717,5686,5694,5692,5702,5695,5710,5685,5691,5704,5719,5706,5709,5690,9861,5705,5700,5711	PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,PSME1,PSMD9,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSME4,PSMD14,PSMD11,PSMA5,PSMB6,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,PSMC4,PSMD13,PSMC6,PSMD3,PSMB2,PSMD6,PSMC5,PSMC1,PSMD5
R-HSA-5205685	Pink/Parkin Mediated Mitophagy	3.81535186745365e-05	-10.1738925718648	22	18	0.00572155117609663	3146	8202	5071,9868,9804,7311,54543,9140,10452,7416,81631,7316,9927,401505,55669,8878,6233,56993,9474,7314	PARK2,TOMM70A,TOMM20,UBA52,TOMM7,ATG12,TOMM40,VDAC1,MAP1LC3B,UBC,MFN2,TOMM5,MFN1,SQSTM1,RPS27A,TOMM22,ATG5,UBB
R-HSA-5205647	Mitophagy	3.81535186745365e-05	-10.1738925718648	22	18	0.00572155117609663	3146	8202	5071,9868,9804,7311,54543,9140,10452,7416,81631,7316,9927,401505,55669,8878,6233,56993,9474,7314	PARK2,TOMM70A,TOMM20,UBA52,TOMM7,ATG12,TOMM40,VDAC1,MAP1LC3B,UBC,MFN2,TOMM5,MFN1,SQSTM1,RPS27A,TOMM22,ATG5,UBB
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	4.41727045303523e-05	-10.027403504202	63	40	0.0127145581691036	3146	8202	2033,5440,57461,2071,8450,3978,3980,404672,5424,5111,6917,2068,9716,7314,5984,3150,1161,5438,7311,5983,5441,5436,9978,10450,5433,10714,5982,5430,7316,5432,4331,5426,5427,6233,2074,5434,5981,91603,1642,5425	EP300,POLR2K,ISY1,ERCC3,CUL4B,LIG1,LIG3,GTF2H5,POLD1,PCNA,TCEA1,ERCC2,AQR,UBB,RFC4,HMGN1,ERCC8,POLR2I,UBA52,RFC3,POLR2L,POLR2G,RBX1,PPIE,POLR2D,POLD3,RFC2,POLR2A,UBC,POLR2C,MNAT1,POLE,POLE2,RPS27A,ERCC6,POLR2E,RFC1,ZNF830,DDB1,POLD2
R-HSA-674695	RNA Polymerase II Pre-transcription Events	4.44955173665842e-05	-10.0201221072012	65	41	0.0130324221233312	3146	8202	51497,9150,6884,5440,6872,6908,2071,102157402,404672,2962,8178,83860,2963,6882,6917,2068,2959,25920,6881,6877,5438,6923,5441,5436,7936,5433,6921,6875,6829,5430,6873,5432,4331,905,6827,2957,5434,22916,6883,6878,6749	NELFCD,CTDP1,TAF13,POLR2K,TAF1,TBP,ERCC3,AK6,GTF2H5,GTF2F1,ELL,TAF3,GTF2F2,TAF11,TCEA1,ERCC2,GTF2B,NELFB,TAF10,TAF5,POLR2I,TCEB2,POLR2L,POLR2G,NELFE,POLR2D,TCEB1,TAF4B,SUPT5H,POLR2A,TAF2,POLR2C,MNAT1,CCNT2,SUPT4H1,GTF2A1,POLR2E,NCBP2,TAF12,TAF6,SSRP1
R-HSA-167172	Transcription of the HIV genome	4.46318182919447e-05	-10.0170635386799	67	42	0.0133502860775588	3146	8202	51497,9150,6884,6872,2071,5440,6908,102157402,404672,2962,8178,83860,2963,6917,2068,6882,2959,25920,6881,6877,5438,5441,6923,5436,8731,7936,5433,6921,6875,6829,5430,4331,6873,5432,905,6827,2957,5434,22916,6883,6878,6749	NELFCD,CTDP1,TAF13,TAF1,ERCC3,POLR2K,TBP,AK6,GTF2H5,GTF2F1,ELL,TAF3,GTF2F2,TCEA1,ERCC2,TAF11,GTF2B,NELFB,TAF10,TAF5,POLR2I,POLR2L,TCEB2,POLR2G,RNMT,NELFE,POLR2D,TCEB1,TAF4B,SUPT5H,POLR2A,MNAT1,TAF2,POLR2C,CCNT2,SUPT4H1,GTF2A1,POLR2E,NCBP2,TAF12,TAF6,SSRP1
R-HSA-5693532	DNA Double-Strand Break Repair	4.48259420883105e-05	-10.0127235216653	162	87	0.0276541640178004	3146	8202	5599,5883,10524,9656,5424,580,8365,5111,84464,890,8366,8364,7516,27343,84126,4361,23514,55775,5984,2067,5983,5810,7311,51548,10635,2140,27434,672,5982,83695,9156,8294,5889,23030,7336,7158,6233,197342,3014,9031,51720,3838,7517,5981,79184,5536,5429,7334,10721,84142,51588,63967,8367,55183,322,1111,2072,3980,641,80010,8360,7341,121504,25,1763,6047,8345,7314,11073,5591,5531,7468,3981,9025,8368,10714,7316,7520,79728,5426,5427,80198,5888,8467,79840,5425,151987	MAPK8,RAD9A,KAT5,MDC1,POLD1,BARD1,HIST1H4H,PCNA,SLX4,CCNA2,HIST1H4B,HIST1H4C,XRCC2,POLL,ATRIP,MRE11A,SPIDR,TDP1,RFC4,ERCC1,RFC3,RAD1,UBA52,SIRT6,RAD51AP1,EYA3,POLM,BRCA1,RFC2,RHNO1,EXO1,HIST1H4I,RAD51C,KDM4B,UBE2V2,TP53BP1,RPS27A,EME2,H2AFX,BAZ1B,UIMC1,KPNA2,XRCC3,RFC1,BRCC3,PPP5C,POLH,UBE2N,POLQ,FAM175A,PIAS4,CLSPN,HIST1H4E,RIF1,APBB1,CHEK1,ERCC4,LIG3,BLM,RMI1,HIST1H4D,SUMO1,HIST4H4,ABL1,DNA2,RNF4,HIST1H2BH,UBB,TOPBP1,PRKDC,PPP4C,WHSC1,LIG4,RNF8,HIST1H4L,POLD3,UBC,XRCC5,PALB2,POLE,POLE2,MUS81,RAD51,SMARCA5,NHEJ1,POLD2,PPP4R2
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	5.38036631197259e-05	-9.83016900538715	24	19	0.00603941513032422	3146	8202	5170,4303,207,2931,7249,2475,3164,208,842,79109,1147,1026,2309,4193,2932,1027,253260,64223,6199	PDPK1,FOXO4,AKT1,GSK3A,TSC2,MTOR,NR4A1,AKT2,CASP9,MAPKAP1,CHUK,CDKN1A,FOXO3,MDM2,GSK3B,CDKN1B,RICTOR,MLST8,RPS6KB2
R-HSA-2559583	Cellular Senescence	5.53401120717284e-05	-9.80201255845886	187	98	0.0311506675143039	3146	8202	5599,3015,3397,23512,10524,8358,8350,1026,898,6015,5606,8365,3490,54386,1031,64682,4193,6196,890,65057,8366,8364,51343,51529,26277,10393,84733,1027,4361,51434,7321,1032,5970,1021,8331,8352,7311,1871,23466,8550,8697,8294,6233,8351,3009,3014,3020,8338,1870,5594,4343,8535,1030,51433,23112,23043,8367,3008,2113,8360,2146,121504,5601,653604,8345,5598,7314,6774,25842,6667,8968,5931,5609,7867,22955,29882,8368,8357,7324,7316,5595,3012,8334,2114,996,3569,5608,7027,23523,3159,4217,11065,7013,6416,6197,192669,1029,8354	MAPK8,H2AFZ,ID1,SUZ12,KAT5,HIST1H3B,HIST1H3A,CDKN1A,CCNE1,RING1,MAP2K3,HIST1H4H,IGFBP7,TERF2IP,CDKN2C,ANAPC1,MDM2,RPS6KA2,CCNA2,ACD,HIST1H4B,HIST1H4C,FZR1,ANAPC11,TINF2,ANAPC10,CBX2,CDKN1B,MRE11A,ANAPC7,UBE2D1,CDKN2D,RELA,CDK6,HIST1H2AJ,HIST1H3C,UBA52,E2F3,CBX6,MAPKAPK5,CDC23,HIST1H4I,RPS27A,HIST1H3D,HIST1H1B,H2AFX,H3F3A,HIST2H2AC,E2F2,MAPK1,MOV10,CBX4,CDKN2B,ANAPC5,TNRC6B,TNIK,HIST1H4E,HIST1H1E,ETS1,HIST1H4D,EZH2,HIST4H4,MAPK9,HIST2H3D,HIST1H2BH,MAPK7,UBB,STAT3,ASF1A,SP1,HIST1H3F,RBBP7,MAP2K7,MAPKAPK3,SCMH1,ANAPC2,HIST1H4L,HIST1H3H,UBE2E1,UBC,MAPK3,HIST1H2AE,HIST1H2AC,ETS2,CDC27,IL6,MAP2K6,TFDP1,CABIN1,HMGA1,MAP3K5,UBE2C,TERF1,MAP2K4,RPS6KA3,AGO3,CDKN2A,HIST1H3I
R-HSA-195721	Signaling by Wnt	6.03735703542903e-05	-9.71495912570394	326	159	0.0505403687221869	3146	8202	3015,55366,8454,51701,2782,10524,8358,1488,8350,5720,3709,2535,5881,5519,8365,1387,5696,1499,8366,5688,5701,163,9070,8331,9736,8352,7311,9978,208,1454,857,6659,80319,5719,6233,59345,1213,3065,5690,2932,5527,5705,409,5700,5528,5689,5693,64840,6662,5713,808,5532,84133,90780,5715,4040,5686,8968,7090,139285,5702,23513,8368,5685,5691,6934,5704,9580,160,3708,5534,7534,1487,81847,192669,8354,2033,5683,2785,5879,6597,324,8658,2783,7474,5687,57680,8364,23198,10213,1856,8321,79412,207,8322,123169,8452,5695,23401,25776,1857,7481,26108,3710,8324,8294,5529,7514,5706,5709,8351,3014,9861,8338,3020,4343,57154,1175,5711,23112,1173,8367,8325,5716,1452,5929,9491,8360,9559,121504,56998,5708,50999,10681,8724,283149,653604,5717,8345,7314,5694,7091,387,5692,7480,7976,9101,64750,5710,4221,8357,7316,22943,3012,8334,10023,6259,7855,51699	H2AFZ,LGR4,CUL1,NLK,GNB1,KAT5,HIST1H3B,CTBP2,HIST1H3A,PSME1,ITPR2,FZD2,RAC3,PPP2R1B,HIST1H4H,CREBBP,PSMB8,CTNNB1,HIST1H4B,PSMA7,PSMC2,AP2B1,ASH2L,HIST1H2AJ,USP34,HIST1H3C,UBA52,RBX1,AKT2,CSNK1E,CAV1,SOX4,CXXC4,PSMD13,RPS27A,GNB4,CLTC,HDAC1,PSMB2,GSK3B,PPP2R5C,PSMC5,ARRB2,PSMC1,PPP2R5D,PSMB1,PSMB5,PORCN,SOX9,PSMD7,CALM3,PPP3CB,ZNRF3,PYGO2,PSMD9,LRP6,PSMA5,HIST1H3F,TLE3,AMER1,PSMC3,SCRIB,HIST1H4L,PSMA4,PSMB3,TCF7L2,PSMC4,SOX13,AP2A1,ITPR1,PPP3R1,YWHAZ,CTBP1,RNF146,AGO3,HIST1H3I,EP300,PSMA2,GNG3,RAC1,SMARCA4,APC,TNKS,GNB2,WNT5A,PSMA6,CHD8,HIST1H4C,PSME4,PSMD14,DVL2,FZD1,KREMEN2,AKT1,FZD4,LEO1,CUL3,PSMB7,FRAT2,CBY1,DVL3,WNT11,PYGO1,ITPR3,FZD7,HIST1H4I,PPP2R5E,XPO1,PSMC6,PSMD3,HIST1H3D,H2AFX,PSMD6,HIST2H2AC,H3F3A,MOV10,SMURF1,AP2S1,PSMD5,TNRC6B,AP2M1,HIST1H4E,FZD8,PSMD10,CSNK1A1,RBBP5,PSMF1,HIST1H4D,VPS26A,HIST4H4,CTNNBIP1,PSMD2,TMED5,GNB5,SNX3,BCL9L,HIST2H3D,PSMD11,HIST1H2BH,UBB,PSMB6,TLE4,RHOA,PSMB4,WNT10B,FZD3,USP8,SMURF2,PSMD4,MEN1,HIST1H3H,UBC,DKK1,HIST1H2AE,HIST1H2AC,FRAT1,RYK,FZD5,VPS29
R-HSA-535734	Fatty acid, triacylglycerol, and ketone body metabolism	6.20070579568177e-05	-9.68826234138505	212	109	0.0346471710108074	3146	8202	2033,9374,2180,5565,6256,10554,1375,64900,25942,64834,253558,29079,1632,1387,4899,23054,9441,1490,6721,55326,3032,7004,4199,2182,9524,55588,23171,31,10498,8463,84693,80205,5468,9200,10413,10025,641371,9969,137964,23097,80724,25937,406,211,9282,9575,10891,9412,10005,2710,84803,51003,56894,6319,2819,3157,81857,112950,84246,4520,117145,9968,3155,9443,8694,5469,79888,4801,6837,6576,55856,2222,6667,3156,7296,23309,60481,5096,1024,7003,65985,79071,56895,2181,83401,8841,5465,2194,2274,1892,6604,166785,5467,57761,8202,51422,201562,51,51586,4802,254531,84649,38,9440,6907,9611,57678,2101,11332	EP300,PPT2,ACSL1,PRKAB2,RXRA,AGPAT1,CPT1B,LPIN3,SIN3A,ELOVL1,LCLAT1,MED4,ECI1,CREBBP,NRF1,NCOA6,MED26,CTGF,SREBF2,AGPAT5,HADHB,TEAD4,ME1,ACSL4,TECR,MED29,GPD1L,ACACA,CARM1,TEAD2,MCEE,CHD9,PPARG,HACD1,YAP1,MED16,ACOT1,MED13,GPAT4,CDK19,ACAD10,WWTR1,ARNTL,ALAS1,MED14,CLOCK,PPARGC1A,MED21,ACOT8,GK,GPAT3,MED31,AGPAT3,SCD,GPD1,HMGCS1,MED25,MED8,MED10,MTF1,THEM4,MED12,HMGCL,MED7,DGAT1,MED1,LPCAT1,NFYB,MED22,SLC25A1,ACOT13,FDFT1,SP1,HMGCR,TXNRD1,SIN3B,ELOVL5,PCCB,CDK8,TEAD1,AACS,ELOVL6,AGPAT4,ACSL3,ELOVL3,HDAC3,PPARA,FASN,FHL2,ECHS1,SMARCD3,MMAA,PPARD,TRIB3,NCOA3,PRKAG2,HACD2,ACOX1,MED15,NFYC,LPCAT4,DGAT2,ACAT1,MED17,TBL1X,NCOR1,GPAM,ESRRA,ACOT7
R-HSA-351202	Metabolism of polyamines	6.35299243369612e-05	-9.66399951366779	84	50	0.0158931977113795	3146	8202	6723,5689,5693,5683,84245,435,5713,51686,5716,5720,5715,9491,4507,5708,5687,5696,5688,5701,10213,23198,51582,5717,1152,51074,5686,113451,5694,58478,1373,5692,262,5702,6303,5695,5710,4953,5685,5691,5704,10166,5719,5706,5709,4947,5690,9861,5705,5700,4946,5711	SRM,PSMB1,PSMB5,PSMA2,MRI1,ASL,PSMD7,OAZ3,PSMD10,PSME1,PSMD9,PSMF1,MTAP,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSMD14,PSME4,AZIN1,PSMD11,CKB,APIP,PSMA5,AZIN2,PSMB6,ENOPH1,CPS1,PSMB4,AMD1,PSMC3,SAT1,PSMB7,PSMD4,ODC1,PSMA4,PSMB3,PSMC4,SLC25A15,PSMD13,PSMC6,PSMD3,OAZ2,PSMB2,PSMD6,PSMC5,PSMC1,OAZ1,PSMD5
R-HSA-446203	Asparagine N-linked glycosylation	6.63478604974245e-05	-9.6205990434117	181	95	0.0301970756516211	3146	8202	9945,4351,64841,5589,26984,7841,1798,55757,821,9919,9117,6484,9695,81562,22845,10342,3998,144245,79796,10802,10484,23256,8813,7039,26503,55741,5861,10610,91869,29926,6487,4122,79947,5372,10195,1650,51009,4253,29925,440138,6482,8704,6396,7109,9871,10825,10905,79087,6480,10020,79053,2923,10652,54344,56886,8702,5373,966,8818,811,4245,1075,9632,79868,1603,81876,5238,22870,6811,10113,56052,2673,83696,9761,375056,80267,10282,256435,1294,84447,122553,51693,10427,51128,2517,22872,27095,63908,199857,9554,2720,85365,55291,8775,79090	GFPT2,MPI,GNPNAT1,PRKCSH,SEC22A,MOGS,DPAGT1,UGGT2,CANX,SEC16A,SEC22C,ST3GAL4,EDEM1,LMAN2L,DOLK,TFG,LMAN1,ALG10B,ALG9,SEC24A,SEC23A,SCFD1,DPM1,TGFA,SLC17A5,EDEM2,RAB1A,ST6GALNAC2,RFT1,GMPPA,ST3GAL3,MAN2A2,DHDDS,PMM1,ALG3,DDOST,DERL2,CTAGE5,GMPPB,ALG11,ST3GAL1,B4GALT2,SEC13,TRAPPC10,SEC24D,NEU3,MAN1A2,ALG12,ST6GAL1,GNE,ALG8,PDIA3,YKT6,DPM3,UGGT1,B4GALT4,PMM2,CD59,DPM2,CALR,MGAT1,CTSC,SEC24C,ALG13,DAD1,RAB1B,PGM3,PPP6R1,STX5,PREB,ALG1,GFPT1,TRAPPC9,MLEC,MIA3,EDEM3,BET1,ST6GALNAC3,COL7A1,SYVN1,TRAPPC6B,TRAPPC2L,SEC24B,SAR1B,FUCA1,SEC31A,TRAPPC3,NAPB,ALG14,SEC22B,GLB1,ALG2,PPP6R3,NAPA,TRAPPC6A
R-HSA-72165	mRNA Splicing - Minor Pathway	6.63828144685786e-05	-9.62007235322541	50	33	0.0104895104895105	3146	8202	10594,9410,23020,5438,55599,5436,5441,5440,51639,5433,6636,6635,10081,10907,154007,5430,83443,23450,2962,9416,10992,5432,55954,6427,9343,5434,2963,57819,4904,22916,6637,24148,6633	PRPF8,SNRNP40,SNRNP200,POLR2I,RNPC3,POLR2G,POLR2L,POLR2K,SF3B6,POLR2D,SNRPF,SNRPE,PDCD7,TXNL4A,SNRNP48,POLR2A,SF3B5,SF3B3,GTF2F1,DDX23,SF3B2,POLR2C,ZMAT5,SRSF2,EFTUD2,POLR2E,GTF2F2,LSM2,YBX1,NCBP2,SNRPG,PRPF6,SNRPD2
R-HSA-5358351	Signaling by Hedgehog	6.75647559094109e-05	-9.60242407315875	135	74	0.0235219326128417	3146	8202	5683,54903,8454,26160,5720,5566,22873,5687,5696,5034,23288,5688,115,5701,10213,23198,5567,7311,9978,83737,8452,5695,5727,5719,5706,51009,6233,7289,5709,55764,5690,2932,9861,5705,409,57154,5700,5711,8650,5689,55081,5693,5713,5716,5715,1452,9491,2619,2622,5708,2737,5717,79659,7314,339745,5686,5694,6868,51098,5692,5702,84447,64750,5710,5685,5691,7316,5704,2778,57728,55733,8481,11127,85455	PSMA2,MKS1,CUL1,IFT172,PSME1,PRKACA,DZIP1,PSMA6,PSMB8,P4HB,IQCE,PSMA7,ADCY9,PSMC2,PSMD14,PSME4,PRKACB,UBA52,RBX1,ITCH,CUL3,PSMB7,PTCH1,PSMD13,PSMC6,DERL2,RPS27A,TULP3,PSMD3,IFT122,PSMB2,GSK3B,PSMD6,PSMC5,ARRB2,SMURF1,PSMC1,PSMD5,NUMB,PSMB1,IFT57,PSMB5,PSMD7,PSMD10,PSMD9,CSNK1A1,PSMF1,GAS1,GAS8,PSMD2,GLI3,PSMD11,DYNC2H1,UBB,SPOPL,PSMA5,PSMB6,ADAM17,IFT52,PSMB4,PSMC3,SYVN1,SMURF2,PSMD4,PSMA4,PSMB3,UBC,PSMC4,GNAS,WDR19,HHAT,OFD1,KIF3A,DISP2
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	7.05915072654832e-05	-9.55860071439098	26	20	0.00635727908455181	3146	8202	7311,64750,5501,9372,7316,10273,4088,4087,7514,25805,6233,9110,51377,23645,5500,5499,7314,57154,11171,9958	UBA52,SMURF2,PPP1CC,ZFYVE9,UBC,STUB1,SMAD3,SMAD2,XPO1,BAMBI,RPS27A,MTMR4,UCHL5,PPP1R15A,PPP1CB,PPP1CA,UBB,SMURF1,STRAP,USP15
R-HSA-76046	RNA Polymerase III Transcription Initiation	7.20701737457438e-05	-9.53787027823932	35	25	0.00794659885568976	3146	8202	2976,2975,5441,5440,9328,6908,171568,55814,5451,84265,2971,7702,6618,51728,11128,5434,9329,27297,2972,55703,6619,9533,10302,6617,10621	GTF3C2,GTF3C1,POLR2L,POLR2K,GTF3C5,TBP,POLR3H,BDP1,POU2F1,POLR3GL,GTF3A,ZNF143,SNAPC2,POLR3K,POLR3A,POLR2E,GTF3C4,CRCP,BRF1,POLR3B,SNAPC3,POLR1C,SNAPC5,SNAPC1,POLR3F
R-HSA-3858494	Beta-catenin independent WNT signaling	7.46305018880079e-05	-9.50296126182674	144	78	0.0247933884297521	3146	8202	2785,5683,5879,51701,2782,5720,3709,2535,5881,2783,7474,5696,5687,1499,5688,5701,10213,23198,163,1856,8321,7311,8322,5695,1857,7481,3710,8324,5719,6233,5706,59345,5709,1213,5690,5705,9861,409,57154,4343,5700,1175,5711,5689,23112,1173,5693,8325,5713,808,5716,5532,5715,9491,5708,10681,5717,7314,5686,5694,387,5692,7976,5702,23513,64750,5710,5685,5691,6934,7316,5704,160,3708,6259,5534,7855,192669	GNG3,PSMA2,RAC1,NLK,GNB1,PSME1,ITPR2,FZD2,RAC3,GNB2,WNT5A,PSMB8,PSMA6,CTNNB1,PSMA7,PSMC2,PSMD14,PSME4,AP2B1,DVL2,FZD1,UBA52,FZD4,PSMB7,DVL3,WNT11,ITPR3,FZD7,PSMD13,RPS27A,PSMC6,GNB4,PSMD3,CLTC,PSMB2,PSMC5,PSMD6,ARRB2,SMURF1,MOV10,PSMC1,AP2S1,PSMD5,PSMB1,TNRC6B,AP2M1,PSMB5,FZD8,PSMD7,CALM3,PSMD10,PPP3CB,PSMD9,PSMF1,PSMD2,GNB5,PSMD11,UBB,PSMA5,PSMB6,RHOA,PSMB4,FZD3,PSMC3,SCRIB,SMURF2,PSMD4,PSMA4,PSMB3,TCF7L2,UBC,PSMC4,AP2A1,ITPR1,RYK,PPP3R1,FZD5,AGO3
R-HSA-6783310	Fanconi Anemia Pathway	8.86185973592941e-05	-9.33116881990458	39	27	0.00858232676414495	3146	8202	2067,7311,2176,2177,201254,22909,2072,353497,57697,2189,2175,2178,55215,7316,2187,55120,84464,29089,80198,6233,197342,91442,80233,199990,84126,7398,7314	ERCC1,UBA52,FANCC,FANCD2,STRA13,FAN1,ERCC4,POLN,FANCM,FANCG,FANCA,FANCE,FANCI,UBC,FANCB,FANCL,SLX4,UBE2T,MUS81,RPS27A,EME2,FAAP24,FAAP100,FAAP20,ATRIP,USP1,UBB
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	0.000100410981172469	-9.20623898245979	83	49	0.0155753337571519	3146	8202	7508,2071,54617,8450,3978,2072,3980,404672,5424,7341,5886,5111,51138,8533,5887,54778,64708,79913,2068,125476,7314,2067,1643,5984,10445,7311,5983,9318,9978,10714,5982,7316,85015,10401,4331,5426,50813,5427,7336,6233,60,2073,5981,10980,7528,83444,7334,5425,1642	XPC,ERCC3,INO80,CUL4B,LIG1,ERCC4,LIG3,GTF2H5,POLD1,SUMO1,RAD23A,PCNA,COPS4,COPS3,RAD23B,RNF111,COPS7B,ACTR5,ERCC2,INO80C,UBB,ERCC1,DDB2,RFC4,MCRS1,UBA52,RFC3,COPS2,RBX1,POLD3,RFC2,UBC,USP45,PIAS3,MNAT1,POLE,COPS7A,POLE2,UBE2V2,RPS27A,ACTB,ERCC5,RFC1,COPS6,YY1,INO80B,UBE2N,POLD2,DDB1
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.000102138750161088	-9.18917837334708	43	29	0.00921805467260013	3146	8202	7323,1030,7050,7311,1024,1875,64750,4221,8239,7316,4088,51592,22938,905,4087,6233,1874,3726,25937,7027,3065,54778,5494,9611,7029,7321,7314,4089,6667	UBE2D3,CDKN2B,TGIF1,UBA52,CDK8,E2F5,SMURF2,MEN1,USP9X,UBC,SMAD3,TRIM33,SNW1,CCNT2,SMAD2,RPS27A,E2F4,JUNB,WWTR1,TFDP1,HDAC1,RNF111,PPM1A,NCOR1,TFDP2,UBE2D1,UBB,SMAD4,SP1
R-HSA-1236975	Antigen processing-Cross presentation	0.000103465496542597	-9.17627236757608	81	48	0.0152574698029243	3146	8202	5689,5693,5683,6890,5713,5716,2923,567,5720,3693,5715,9491,3105,811,5708,5696,5687,5688,5701,23198,10213,5717,6891,7314,5686,55176,5694,7311,5692,5702,5695,5710,5685,5691,7316,5704,1535,5719,29927,6233,5706,5709,5690,3685,5705,9861,5700,5711	PSMB1,PSMB5,PSMA2,TAP1,PSMD7,PSMD10,PDIA3,B2M,PSME1,ITGB5,PSMD9,PSMF1,HLA-A,CALR,PSMD2,PSMB8,PSMA6,PSMA7,PSMC2,PSME4,PSMD14,PSMD11,TAP2,UBB,PSMA5,SEC61A2,PSMB6,UBA52,PSMB4,PSMC3,PSMB7,PSMD4,PSMA4,PSMB3,UBC,PSMC4,CYBA,PSMD13,SEC61A1,RPS27A,PSMC6,PSMD3,PSMB2,ITGAV,PSMC5,PSMD6,PSMC1,PSMD5
R-HSA-2559585	Oncogene Induced Senescence	0.00010475576729307	-9.16387894298724	30	22	0.00699300699300699	3146	8202	1030,23112,7311,3397,1871,2113,7316,5595,1031,4193,2114,6233,7027,7314,1870,5594,4343,1032,1021,1029,192669,6667	CDKN2B,TNRC6B,UBA52,ID1,E2F3,ETS1,UBC,MAPK3,CDKN2C,MDM2,ETS2,RPS27A,TFDP1,UBB,E2F2,MAPK1,MOV10,CDKN2D,CDK6,CDKN2A,AGO3,SP1
R-HSA-429947	Deadenylation of mRNA	0.000112360274627293	-9.09380011155809	23	18	0.00572155117609663	3146	8202	23019,255967,9337,1974,29883,85456,55571,5073,4849,9924,9125,4848,1981,9775,57472,1977,4850,26986	CNOT1,PAN3,CNOT8,EIF4A2,CNOT7,TNKS1BP1,CNOT11,PARN,CNOT3,PAN2,RQCD1,CNOT2,EIF4G1,EIF4A3,CNOT6,EIF4E,CNOT4,PABPC1
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	0.000112360274627293	-9.09380011155809	23	18	0.00572155117609663	3146	8202	51433,7311,991,29882,8697,7316,7324,64682,996,6233,51529,4085,10393,4751,51434,7321,7314,11065	ANAPC5,UBA52,CDC20,ANAPC2,CDC23,UBC,UBE2E1,ANAPC1,CDC27,RPS27A,ANAPC11,MAD2L1,ANAPC10,NEK2,ANAPC7,UBE2D1,UBB,UBE2C
R-HSA-166520	Signalling by NGF	0.000112449389479918	-9.09300730883187	430	202	0.0642085187539733	3146	8202	836,7249,4763,5786,5720,1026,3709,7531,5519,84894,5906,5696,6196,5688,5296,5701,5664,1785,163,10818,5567,6453,64223,7311,9978,51107,208,842,283455,5898,5335,1398,5719,6233,4296,3065,4254,5690,2932,5527,5705,409,5700,2549,5528,3066,64857,5125,2245,5689,5693,7410,7204,5245,8649,5713,5900,814,808,4205,10256,5715,83464,1847,5581,8878,5584,10018,5598,5686,7867,8841,5702,5908,8437,84033,6016,5605,5685,5691,5921,5704,57498,23421,1845,160,3708,2069,6197,192669,5599,161742,200734,685,10142,26052,5607,9462,2475,5683,5894,8826,5037,5879,5604,2064,1147,5566,1399,4193,5687,6464,5899,6711,115,3551,835,23198,10213,8503,1027,253260,10768,9828,7414,5970,10126,6655,207,2931,8452,5695,1742,11214,1846,3710,2260,8660,5529,817,2534,27018,5706,5709,80824,396,5536,9861,5594,4343,1175,23385,5711,23112,1844,1173,673,50650,79109,5716,57142,9252,2309,9491,466,57449,5708,117145,9138,5781,9181,3717,5717,2065,7314,6774,6199,1843,6709,5694,5170,6868,387,5692,4303,6654,3164,10276,5295,5045,23365,5747,5710,7316,5595,2885,57761,84078,152559,84292,23229,3265	CASP3,TSC2,NF1,PTPRA,PSME1,CDKN1A,ITPR2,YWHAE,PPP2R1B,LINGO1,RAP1A,PSMB8,RPS6KA2,PSMA7,PIK3R2,PSMC2,PSEN2,DNM2,AP2B1,FRS2,PRKACB,ITSN1,MLST8,UBA52,RBX1,APH1A,AKT2,CASP9,KSR2,RALA,PLCG1,CRK,PSMD13,RPS27A,MAP3K11,HDAC1,KITLG,PSMB2,GSK3B,PPP2R5C,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,HDAC2,PLEKHG2,PCSK5,FGD1,PSMB1,PSMB5,VAV2,TRIO,PHB,LAMTOR3,PSMD7,RALGDS,CAMK4,CALM3,MEF2A,CNKSR1,PSMD9,APH1B,DUSP5,PRKCE,SQSTM1,PRKCI,BCL2L11,MAPK7,PSMA5,MAPKAPK3,HDAC3,PSMC3,RAP1B,RASAL1,OBSCN,RIT1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,KIDINS220,ITGB3BP,DUSP3,AP2A1,ITPR1,EREG,RPS6KA3,AGO3,MAPK8,SPRED1,SPRED2,BTC,AKAP9,DNM3,MAP2K5,RASAL2,MTOR,PSMA2,RAF1,IQGAP1,PEBP1,RAC1,MAP2K1,ERBB2,CHUK,PRKACA,CRKL,MDM2,PSMA6,SHC1,RALB,SPTBN1,ADCY9,IKBKB,CASP2,PSME4,PSMD14,PIK3R3,CDKN1B,RICTOR,AHCYL1,ARHGEF17,VCL,RELA,DNAL4,SOS2,AKT1,GSK3A,CUL3,PSMB7,DLG4,AKAP13,DUSP4,ITPR3,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,NGFRAP1,PSMC6,PSMD3,DUSP16,ARHGDIA,PPP5C,PSMD6,MAPK1,MOV10,AP2S1,NCSTN,PSMD5,TNRC6B,DUSP2,AP2M1,BRAF,ARHGEF3,MAPKAP1,PSMD10,RTN4,RPS6KA5,FOXO3,PSMF1,ATF1,PLEKHG5,PSMD2,THEM4,ARHGEF1,PTPN11,ARHGEF2,JAK2,PSMD11,ERBB3,UBB,STAT3,RPS6KB2,DUSP1,SPTAN1,PSMB6,PDPK1,ADAM17,RHOA,PSMB4,FOXO4,SOS1,NR4A1,NET1,PIK3R1,FURIN,ARHGEF12,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,ARHGEF9,HRAS
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	0.000121167596292152	-9.01833587740088	18	15	0.00476795931341386	3146	8202	7323,7311,112398,6923,2034,3091,9978,6233,8453,7322,6921,7314,7321,112399,7316	UBE2D3,UBA52,EGLN2,TCEB2,EPAS1,HIF1A,RBX1,RPS27A,CUL2,UBE2D2,TCEB1,UBB,UBE2D1,EGLN3,UBC
R-HSA-69481	G2/M Checkpoints	0.000145308290408466	-8.83665293183428	105	59	0.0187539732994278	3146	8202	51588,84142,5883,4175,55388,63967,8367,10926,10524,1111,7531,9656,891,580,8360,7341,8365,121504,7465,8366,8317,8364,84126,4361,8345,23595,993,5984,4999,5810,5983,7468,10971,990,672,9025,9088,8368,995,5982,983,7532,8294,8318,5000,7336,7158,5001,84515,3014,51720,7534,79184,7533,9133,7334,2810,23594,4172	PIAS4,FAM175A,RAD9A,MCM6,MCM10,CLSPN,HIST1H4E,DBF4,KAT5,CHEK1,YWHAE,MDC1,CCNB1,BARD1,HIST1H4D,SUMO1,HIST1H4H,HIST4H4,WEE1,HIST1H4B,CDC7,HIST1H4C,ATRIP,MRE11A,HIST1H2BH,ORC3,CDC25A,RFC4,ORC2,RAD1,RFC3,WHSC1,YWHAQ,CDC6,BRCA1,RNF8,PKMYT1,HIST1H4L,CDC25C,RFC2,CDK1,YWHAG,HIST1H4I,CDC45,ORC4,UBE2V2,TP53BP1,ORC5,MCM8,H2AFX,UIMC1,YWHAZ,BRCC3,YWHAH,CCNB2,UBE2N,SFN,ORC6,MCM3
R-HSA-73893	DNA Damage Bypass	0.00019643370764441	-8.53518554925287	46	30	0.00953591862682772	3146	8202	7353,5984,5983,7311,9978,8450,10714,5982,5424,10459,7316,9636,51514,5980,5111,9768,9246,5426,5427,56852,6233,7706,7398,5981,7314,5429,51455,5425,1642,124739	UFD1L,RFC4,RFC3,UBA52,RBX1,CUL4B,POLD3,RFC2,POLD1,MAD2L2,UBC,ISG15,DTL,REV3L,PCNA,KIAA0101,UBE2L6,POLE,POLE2,RAD18,RPS27A,TRIM25,USP1,RFC1,UBB,POLH,REV1,POLD2,DDB1,USP43
R-HSA-73762	RNA Polymerase I Transcription Initiation	0.00020117747801579	-8.51132306429555	48	31	0.00985378258105531	3146	8202	57459,57504,5441,5931,2648,79101,5440,6908,2071,9219,404672,53615,7270,221830,54815,7343,4331,54700,9014,2074,1107,10849,5434,3065,1108,84172,2068,9533,30834,64425,3066	GATAD2B,MTA3,POLR2L,RBBP7,KAT2A,TAF1D,POLR2K,TBP,ERCC3,MTA2,GTF2H5,MBD3,TTF1,TWISTNB,GATAD2A,UBTF,MNAT1,RRN3,TAF1B,ERCC6,CHD3,CD3EAP,POLR2E,HDAC1,CHD4,POLR1B,ERCC2,POLR1C,ZNRD1,POLR1E,HDAC2
R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	0.000203738145568877	-8.49867498879294	12	11	0.0034965034965035	3146	8202	7465,10971,7534,1111,7531,891,7533,995,983,2810,7532	WEE1,YWHAQ,YWHAZ,CHEK1,YWHAE,CCNB1,YWHAH,CDC25C,CDK1,SFN,YWHAG
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	0.000207812535813109	-8.47887415478036	54	34	0.0108073744437381	3146	8202	2033,5440,57461,2071,8450,404672,51138,8533,64708,6917,9716,2068,7314,3150,1161,5438,7311,5441,5436,9318,9978,10450,5433,5430,7316,5432,4331,50813,6233,2074,5434,91603,10980,1642	EP300,POLR2K,ISY1,ERCC3,CUL4B,GTF2H5,COPS4,COPS3,COPS7B,TCEA1,AQR,ERCC2,UBB,HMGN1,ERCC8,POLR2I,UBA52,POLR2L,POLR2G,COPS2,RBX1,PPIE,POLR2D,POLR2A,UBC,POLR2C,MNAT1,COPS7A,RPS27A,ERCC6,POLR2E,ZNF830,COPS6,DDB1
R-HSA-432722	Golgi Associated Vesicle Biogenesis	0.000207812535813109	-8.47887415478036	54	34	0.0108073744437381	3146	8202	6272,8673,25977,2495,375,9685,7164,7037,81567,4952,8907,1785,130340,1362,3482,2512,6643,54885,8905,10717,8546,7163,26258,23431,55330,8301,1213,2580,164,8775,5878,388552,27131,23557	SORT1,VAMP8,NECAP1,FTH1,ARF1,CLINT1,TPD52L1,TFRC,TXNDC5,OCRL,AP1M1,DNM2,AP1S3,CPD,IGF2R,FTL,SNX2,TBC1D8B,AP1S2,AP4B1,AP3B1,TPD52,BLOC1S6,AP4E1,BLOC1S4,PICALM,CLTC,GAK,AP1G1,NAPA,RAB5C,BLOC1S3,SNX5,SNAPIN
R-HSA-167287	HIV elongation arrest and recovery	0.000230240931544279	-8.37638426886277	31	22	0.00699300699300699	3146	8202	51497,9150,5438,5436,6923,5441,5440,7936,5433,6921,6829,5430,2962,5432,8178,905,6827,5434,2963,6917,25920,6749	NELFCD,CTDP1,POLR2I,POLR2G,TCEB2,POLR2L,POLR2K,NELFE,POLR2D,TCEB1,SUPT5H,POLR2A,GTF2F1,POLR2C,ELL,CCNT2,SUPT4H1,POLR2E,GTF2F2,TCEA1,NELFB,SSRP1
R-HSA-167290	Pausing and recovery of HIV elongation	0.000230240931544279	-8.37638426886277	31	22	0.00699300699300699	3146	8202	51497,9150,5438,5436,6923,5441,5440,7936,5433,6921,6829,5430,2962,5432,8178,905,6827,5434,2963,6917,25920,6749	NELFCD,CTDP1,POLR2I,POLR2G,TCEB2,POLR2L,POLR2K,NELFE,POLR2D,TCEB1,SUPT5H,POLR2A,GTF2F1,POLR2C,ELL,CCNT2,SUPT4H1,POLR2E,GTF2F2,TCEA1,NELFB,SSRP1
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.000230240931544279	-8.37638426886277	31	22	0.00699300699300699	3146	8202	1030,7050,7311,1024,1875,4221,7316,4088,905,22938,4087,6233,1874,3726,25937,7027,54778,3065,7029,7314,4089,6667	CDKN2B,TGIF1,UBA52,CDK8,E2F5,MEN1,UBC,SMAD3,CCNT2,SNW1,SMAD2,RPS27A,E2F4,JUNB,WWTR1,TFDP1,RNF111,HDAC1,TFDP2,UBB,SMAD4,SP1
R-HSA-5357905	Regulation of TNFR1 signaling	0.000230240931544279	-8.37638426886277	31	22	0.00699300699300699	3146	8202	7375,10616,7311,7128,330,7186,81858,8887,1147,10399,27005,329,7316,7185,6233,56957,55072,8567,3551,841,7314,90268	USP4,RBCK1,UBA52,TNFAIP3,BIRC3,TRAF2,SHARPIN,TAX1BP1,CHUK,GNB2L1,USP21,BIRC2,UBC,TRAF1,RPS27A,OTUD7B,RNF31,MADD,IKBKB,CASP8,UBB,OTULIN
R-HSA-113510	E2F mediated regulation of DNA replication	0.000254661650023656	-8.27557475651988	33	23	0.00731087094723458	3146	8202	993,4999,5558,5422,6241,990,891,983,898,5519,7084,5557,26271,8318,5111,5000,7027,5001,84515,1719,7298,23595,23594	CDC25A,ORC2,PRIM2,POLA1,RRM2,CDC6,CCNB1,CDK1,CCNE1,PPP2R1B,TK2,PRIM1,FBXO5,CDC45,PCNA,ORC4,TFDP1,ORC5,MCM8,DHFR,TYMS,ORC3,ORC6
R-HSA-176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.00026598301607759	-8.2320781005534	17	14	0.00445009535918627	3146	8202	64682,51433,996,51343,991,51529,10393,29882,51434,8697,7321,11065,8556,7324	ANAPC1,ANAPC5,CDC27,FZR1,CDC20,ANAPC11,ANAPC10,ANAPC2,ANAPC7,CDC23,UBE2D1,UBE2C,CDC14A,UBE2E1
R-HSA-5693567	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	0.00031154421855165	-8.07396927619437	129	69	0.0219326128417038	3146	8202	5883,10524,9656,5424,580,8365,5111,84464,890,8366,8364,7516,84126,4361,23514,5984,2067,5983,5810,7311,51548,10635,672,5982,83695,9156,8294,5889,7336,7158,6233,197342,3014,51720,7517,5981,79184,5429,7334,84142,51588,63967,8367,2072,1111,641,80010,8360,7341,121504,25,1763,6047,8345,7314,11073,5531,7468,9025,8368,10714,7316,5427,5426,79728,5888,80198,5425,151987	RAD9A,KAT5,MDC1,POLD1,BARD1,HIST1H4H,PCNA,SLX4,CCNA2,HIST1H4B,HIST1H4C,XRCC2,ATRIP,MRE11A,SPIDR,RFC4,ERCC1,RFC3,RAD1,UBA52,SIRT6,RAD51AP1,BRCA1,RFC2,RHNO1,EXO1,HIST1H4I,RAD51C,UBE2V2,TP53BP1,RPS27A,EME2,H2AFX,UIMC1,XRCC3,RFC1,BRCC3,POLH,UBE2N,FAM175A,PIAS4,CLSPN,HIST1H4E,ERCC4,CHEK1,BLM,RMI1,HIST1H4D,SUMO1,HIST4H4,ABL1,DNA2,RNF4,HIST1H2BH,UBB,TOPBP1,PPP4C,WHSC1,RNF8,HIST1H4L,POLD3,UBC,POLE2,POLE,PALB2,RAD51,MUS81,POLD2,PPP4R2
R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.000316285484074857	-8.05886532160854	65	39	0.012396694214876	3146	8202	5883,10524,1111,641,5424,580,80010,5111,84464,7516,1763,4361,84126,7314,23514,5984,5810,7311,5983,11073,10635,672,10714,5982,7316,83695,9156,5889,5427,5426,79728,80198,6233,5888,197342,7517,5981,5429,5425	RAD9A,KAT5,CHEK1,BLM,POLD1,BARD1,RMI1,PCNA,SLX4,XRCC2,DNA2,MRE11A,ATRIP,UBB,SPIDR,RFC4,RAD1,UBA52,RFC3,TOPBP1,RAD51AP1,BRCA1,POLD3,RFC2,UBC,RHNO1,EXO1,RAD51C,POLE2,POLE,PALB2,MUS81,RPS27A,RAD51,EME2,XRCC3,RFC1,POLH,POLD2
R-HSA-75893	TNF signaling	0.000322873784298479	-8.03824907179429	41	27	0.00858232676414495	3146	8202	6868,7375,10616,7311,7128,330,257397,7186,81858,8887,1147,10399,8439,27005,329,7316,7185,6233,23118,56957,55072,8567,3551,841,7314,10454,90268	ADAM17,USP4,RBCK1,UBA52,TNFAIP3,BIRC3,TAB3,TRAF2,SHARPIN,TAX1BP1,CHUK,GNB2L1,NSMAF,USP21,BIRC2,UBC,TRAF1,RPS27A,TAB2,OTUD7B,RNF31,MADD,IKBKB,CASP8,UBB,TAB1,OTULIN
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.000344900308833307	-7.97225514259333	47	30	0.00953591862682772	3146	8202	7091,2033,3280,7311,1024,2648,9978,7090,8841,8454,83933,10013,10014,7316,1387,23493,22938,9759,3091,6233,51564,10046,3065,6907,3516,9611,7314,9794,3066,55534	TLE4,EP300,HES1,UBA52,CDK8,KAT2A,RBX1,TLE3,HDAC3,CUL1,HDAC10,HDAC6,HDAC5,UBC,CREBBP,HEY2,SNW1,HDAC4,HIF1A,RPS27A,HDAC7,MAMLD1,HDAC1,TBL1X,RBPJ,NCOR1,UBB,MAML1,HDAC2,MAML3
R-HSA-157118	Signaling by NOTCH	0.000381385516282437	-7.87169984065684	110	60	0.0190718372536554	3146	8202	142678,2033,23112,54567,102,3955,56983,8454,5870,83933,10013,83464,23509,57534,1387,23493,22938,6484,182,488,51564,5664,9794,7314,55534,7091,3280,6868,7311,2648,1024,9978,51107,7090,83737,8841,1871,5045,54492,6487,10014,7316,4192,9759,3091,6233,10046,7027,23220,3065,6907,3516,9611,7029,409,4343,23385,192669,8650,3066	MIB2,EP300,TNRC6B,DLL4,ADAM10,LFNG,POGLUT1,CUL1,RAB6A,HDAC10,HDAC6,APH1B,POFUT1,MIB1,CREBBP,HEY2,SNW1,ST3GAL4,JAG1,ATP2A2,HDAC7,PSEN2,MAML1,UBB,MAML3,TLE4,HES1,ADAM17,UBA52,KAT2A,CDK8,RBX1,APH1A,TLE3,ITCH,HDAC3,E2F3,FURIN,NEURL1B,ST3GAL3,HDAC5,UBC,MDK,HDAC4,HIF1A,RPS27A,MAMLD1,TFDP1,DTX4,HDAC1,TBL1X,RBPJ,NCOR1,TFDP2,ARRB2,MOV10,NCSTN,AGO3,NUMB,HDAC2
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	0.000389583169346537	-7.85043318695825	28	20	0.00635727908455181	3146	8202	5984,5983,7311,9978,8450,10714,5982,5424,7316,51514,5111,5427,56852,5426,6233,7398,5981,7314,1642,5425	RFC4,RFC3,UBA52,RBX1,CUL4B,POLD3,RFC2,POLD1,UBC,DTL,PCNA,POLE2,RAD18,POLE,RPS27A,USP1,RFC1,UBB,DDB1,POLD2
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation	0.000432904491221174	-7.74499342883887	30	21	0.0066751430387794	3146	8202	51497,9150,5438,5436,6923,5441,5440,7936,5433,6921,6829,5430,2962,5432,8178,6827,5434,2963,6917,25920,6749	NELFCD,CTDP1,POLR2I,POLR2G,TCEB2,POLR2L,POLR2K,NELFE,POLR2D,TCEB1,SUPT5H,POLR2A,GTF2F1,POLR2C,ELL,SUPT4H1,POLR2E,GTF2F2,TCEA1,NELFB,SSRP1
R-HSA-5656169	Termination of translesion DNA synthesis	0.000432904491221174	-7.74499342883887	30	21	0.0066751430387794	3146	8202	5984,5983,7311,10714,5982,5424,7316,9636,5111,9246,9768,5426,5427,6233,7706,5981,7314,5429,51455,5425,124739	RFC4,RFC3,UBA52,POLD3,RFC2,POLD1,UBC,ISG15,PCNA,UBE2L6,KIAA0101,POLE,POLE2,RPS27A,TRIM25,RFC1,UBB,POLH,REV1,POLD2,USP43
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery	0.000432904491221174	-7.74499342883887	30	21	0.0066751430387794	3146	8202	51497,9150,5438,5436,6923,5441,5440,7936,5433,6921,6829,5430,2962,5432,8178,6827,5434,2963,6917,25920,6749	NELFCD,CTDP1,POLR2I,POLR2G,TCEB2,POLR2L,POLR2K,NELFE,POLR2D,TCEB1,SUPT5H,POLR2A,GTF2F1,POLR2C,ELL,SUPT4H1,POLR2E,GTF2F2,TCEA1,NELFB,SSRP1
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.000470517915310178	-7.66167652249016	32	22	0.00699300699300699	3146	8202	7311,5045,64750,5501,9372,7316,4088,10273,4087,7514,25805,6233,9110,51377,23645,5500,5499,7314,57154,11171,4089,9958	UBA52,FURIN,SMURF2,PPP1CC,ZFYVE9,UBC,SMAD3,STUB1,SMAD2,XPO1,BAMBI,RPS27A,MTMR4,UCHL5,PPP1R15A,PPP1CB,PPP1CA,UBB,SMURF1,STRAP,SMAD4,USP15
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	0.000489748425671765	-7.62161871569963	198	99	0.0314685314685315	3146	8202	23291,685,7249,2475,5683,2064,8454,1147,5720,1026,3709,4067,30011,4193,5696,5687,6464,6786,5688,3551,5296,5701,23198,10213,1027,8503,7220,253260,10768,5970,10818,64223,7311,2931,207,4690,208,5777,842,5695,3710,2260,8660,5335,2534,5719,5706,6233,5709,4254,5690,2932,5705,9861,4343,5700,2549,5711,5689,23112,5693,5966,5713,5716,79109,808,5715,2309,9491,5708,117145,5781,84876,5717,2065,7314,5686,5694,6199,5170,4303,5692,6654,3164,5295,5702,10892,5710,5685,5691,7316,5704,2885,57761,3708,2069,4793,3265,192669	FBXW11,BTC,TSC2,MTOR,PSMA2,ERBB2,CUL1,CHUK,PSME1,CDKN1A,ITPR2,LYN,SH3KBP1,MDM2,PSMB8,PSMA6,SHC1,STIM1,PSMA7,IKBKB,PIK3R2,PSMC2,PSME4,PSMD14,CDKN1B,PIK3R3,TRPC1,RICTOR,AHCYL1,RELA,FRS2,MLST8,UBA52,GSK3A,AKT1,NCK1,AKT2,PTPN6,CASP9,PSMB7,ITPR3,FGFR1,IRS2,PLCG1,FYN,PSMD13,PSMC6,RPS27A,PSMD3,KITLG,PSMB2,GSK3B,PSMC5,PSMD6,MOV10,PSMC1,GAB1,PSMD5,PSMB1,TNRC6B,PSMB5,REL,PSMD7,PSMD10,MAPKAP1,CALM3,PSMD9,FOXO3,PSMF1,PSMD2,THEM4,PTPN11,ORAI1,PSMD11,ERBB3,UBB,PSMA5,PSMB6,RPS6KB2,PDPK1,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,PSMC3,MALT1,PSMD4,PSMA4,PSMB3,UBC,PSMC4,GRB2,TRIB3,ITPR1,EREG,NFKBIB,HRAS,AGO3
R-HSA-5693538	Homology Directed Repair	0.000492711836022334	-7.61558606592568	135	71	0.0225683407501589	3146	8202	5883,10524,9656,5424,580,8365,5111,84464,890,8366,8364,7516,84126,4361,23514,5984,2067,5983,5810,7311,51548,10635,672,5982,83695,9156,8294,5889,7336,7158,6233,197342,3014,51720,7517,5981,79184,5429,7334,10721,84142,51588,63967,8367,2072,1111,3980,641,80010,8360,7341,121504,25,1763,6047,8345,7314,11073,5531,7468,9025,8368,10714,7316,5427,5426,79728,5888,80198,5425,151987	RAD9A,KAT5,MDC1,POLD1,BARD1,HIST1H4H,PCNA,SLX4,CCNA2,HIST1H4B,HIST1H4C,XRCC2,ATRIP,MRE11A,SPIDR,RFC4,ERCC1,RFC3,RAD1,UBA52,SIRT6,RAD51AP1,BRCA1,RFC2,RHNO1,EXO1,HIST1H4I,RAD51C,UBE2V2,TP53BP1,RPS27A,EME2,H2AFX,UIMC1,XRCC3,RFC1,BRCC3,POLH,UBE2N,POLQ,FAM175A,PIAS4,CLSPN,HIST1H4E,ERCC4,CHEK1,LIG3,BLM,RMI1,HIST1H4D,SUMO1,HIST4H4,ABL1,DNA2,RNF4,HIST1H2BH,UBB,TOPBP1,PPP4C,WHSC1,RNF8,HIST1H4L,POLD3,UBC,POLE2,POLE,PALB2,RAD51,MUS81,POLD2,PPP4R2
R-HSA-212165	Epigenetic regulation of gene expression	0.000499332856625529	-7.6022376372442	124	66	0.020979020979021	3146	8202	3015,2071,23512,8358,8350,404672,25942,5252,8365,79595,6996,8366,10849,8364,30834,8331,8819,8352,23411,121536,5441,11176,29115,8294,7343,8351,3014,3065,10284,3020,8338,22823,3066,6908,8367,5440,26147,23378,7270,8360,2146,121504,9014,8932,653604,84172,2068,8345,29128,64425,8968,23309,5931,79101,51742,8368,8357,221830,4331,8334,3012,5434,8467,9533,6839,8354	H2AFZ,ERCC3,SUZ12,HIST1H3B,HIST1H3A,GTF2H5,SIN3A,PHF1,HIST1H4H,SAP130,TDG,HIST1H4B,CD3EAP,HIST1H4C,ZNRD1,HIST1H2AJ,SAP30,HIST1H3C,SIRT1,AEBP2,POLR2L,BAZ2A,SAP30BP,HIST1H4I,UBTF,HIST1H3D,H2AFX,HDAC1,SAP18,H3F3A,HIST2H2AC,MTF2,HDAC2,TBP,HIST1H4E,POLR2K,PHF19,RRP8,TTF1,HIST1H4D,EZH2,HIST4H4,TAF1B,MBD2,HIST2H3D,POLR1B,ERCC2,HIST1H2BH,UHRF1,POLR1E,HIST1H3F,SIN3B,RBBP7,TAF1D,ARID4B,HIST1H4L,HIST1H3H,TWISTNB,MNAT1,HIST1H2AC,HIST1H2AE,POLR2E,SMARCA5,POLR1C,SUV39H1,HIST1H3I
R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs	0.000528379180760672	-7.54569638662096	36	24	0.00762873490146217	3146	8202	10163,10152,23191,8936,71,4690,10096,5879,10093,5747,10552,10458,5595,2885,25,55845,10092,8976,51517,60,10097,10109,147179,5594	WASF2,ABI2,CYFIP1,WASF1,ACTG1,NCK1,ACTR3,RAC1,ARPC4,PTK2,ARPC1A,BAIAP2,MAPK3,GRB2,ABL1,BRK1,ARPC5,WASL,NCKIPSD,ACTB,ACTR2,ARPC2,WIPF2,MAPK1
R-HSA-109606	Intrinsic Pathway for Apoptosis	0.000549003111963294	-7.50740644804951	38	25	0.00794659885568976	3146	8202	578,5599,4836,836,207,208,8655,842,56616,10971,598,7531,7532,840,5366,7027,581,5534,7534,5533,317,10018,841,7533,2810	BAK1,MAPK8,NMT1,CASP3,AKT1,AKT2,DYNLL1,CASP9,DIABLO,YWHAQ,BCL2L1,YWHAE,YWHAG,CASP7,PMAIP1,TFDP1,BAX,PPP3R1,YWHAZ,PPP3CC,APAF1,BCL2L11,CASP8,YWHAH,SFN
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.000571549656713302	-7.46715919011676	23	17	0.00540368722186904	3146	8202	7323,7050,7311,64750,8239,7316,51592,4088,4087,6233,54778,3065,5494,9611,7321,7314,4089	UBE2D3,TGIF1,UBA52,SMURF2,USP9X,UBC,TRIM33,SMAD3,SMAD2,RPS27A,RNF111,HDAC1,PPM1A,NCOR1,UBE2D1,UBB,SMAD4
R-HSA-167242	Abortive elongation of HIV-1 transcript in the absence of Tat	0.000571549656713302	-7.46715919011676	23	17	0.00540368722186904	3146	8202	51497,9150,5438,5436,5441,5440,7936,5433,6829,5430,2962,5432,6827,5434,2963,22916,25920	NELFCD,CTDP1,POLR2I,POLR2G,POLR2L,POLR2K,NELFE,POLR2D,SUPT5H,POLR2A,GTF2F1,POLR2C,SUPT4H1,POLR2E,GTF2F2,NCBP2,NELFB
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.00057540766142428	-7.46043179198191	42	27	0.00858232676414495	3146	8202	7091,7311,207,208,7090,6662,324,25776,90780,26108,4221,6659,5929,7316,6934,9580,56998,7514,1499,6233,57680,283149,3065,9070,7534,7314,1487	TLE4,UBA52,AKT1,AKT2,TLE3,SOX9,APC,CBY1,PYGO2,PYGO1,MEN1,SOX4,RBBP5,UBC,TCF7L2,SOX13,CTNNBIP1,XPO1,CTNNB1,RPS27A,CHD8,BCL9L,HDAC1,ASH2L,YWHAZ,UBB,CTBP1
R-HSA-5653656	Vesicle-mediated transport	0.000614576823228287	-7.39457661931365	294	140	0.0445009535918627	3146	8202	51552,8218,5565,8673,7531,9919,81567,4218,57148,81562,8907,1785,55770,10342,7311,208,8905,7039,10717,4035,8546,5571,51028,78989,5898,6233,1213,4253,7251,27183,2580,92421,10808,9871,11267,808,7082,10652,9685,84313,4641,9276,811,966,4952,81876,149371,22870,10113,6811,3482,2512,83696,23433,54885,10282,9179,55048,122553,55330,10640,22872,27095,51422,8773,60412,11127,9554,7534,55291,8775,388552,5878,2810,6517,51510,11316,5879,26984,2495,25977,8729,9117,79058,2707,8906,3998,1315,10802,1362,10484,207,23256,9525,10971,7163,25978,5861,23431,10890,7532,10052,22820,27131,6396,1173,6272,7109,375,23265,7164,8766,7037,1075,9632,375519,57186,3320,130340,7314,4646,11154,6643,5872,375056,10525,1294,6810,26258,8301,7316,51693,51128,10427,63908,9882,7533,79090,164,23557	RAB14,CLTCL1,PRKAB2,VAMP8,YWHAE,SEC16A,TXNDC5,RAB8A,RALGAPB,LMAN2L,AP1M1,DNM2,EXOC2,TFG,UBA52,AKT2,AP1S2,TGFA,AP4B1,LRP1,AP3B1,PRKAG1,VPS36,COLEC11,RALA,RPS27A,CLTC,CTAGE5,TSG101,VPS4A,GAK,CHMP4C,HSPH1,SEC24D,SNF8,CALM3,TJP1,YKT6,CLINT1,VPS25,MYO1C,COPB2,CALR,CD59,OCRL,RAB1B,EXOC8,PPP6R1,PREB,STX5,IGF2R,FTL,TRAPPC9,RHOQ,TBC1D8B,BET1,AP4M1,VPS37C,TRAPPC6B,BLOC1S4,EXOC5,SEC31A,TRAPPC3,PRKAG2,SNAP23,EXOC4,KIF3A,SEC22B,YWHAZ,PPP6R3,NAPA,BLOC1S3,RAB5C,SFN,SLC2A4,CHMP5,COPE,RAC1,SEC22A,FTH1,NECAP1,GBF1,SEC22C,ASPSCR1,GJB3,AP1G2,LMAN1,COPB1,SEC24A,CPD,SEC23A,AKT1,SCFD1,VPS4B,YWHAQ,TPD52,CHMP2B,RAB1A,AP4E1,RAB10,YWHAG,GJC1,COPG1,SNX5,SEC13,AP2M1,SORT1,TRAPPC10,ARF1,EXOC7,TPD52L1,RAB11A,TFRC,CTSC,SEC24C,GJB7,RALGAPA2,HSP90AA1,AP1S3,UBB,MYO6,AP4S1,SNX2,RAB13,MIA3,HYOU1,COL7A1,STX4,BLOC1S6,PICALM,UBC,TRAPPC2L,SAR1B,SEC24B,NAPB,TBC1D4,YWHAH,TRAPPC6A,AP1G1,SNAPIN
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.000619896677485774	-7.38595774302915	105	57	0.0181182453909727	3146	8202	1030,51433,3015,8367,8358,8350,1026,8360,8365,3490,121504,1031,64682,6196,890,8366,8364,51343,51529,10393,1027,653604,51434,8345,7314,5598,7321,1032,6774,5970,1021,8331,8968,8352,7311,29882,8697,8368,8357,7316,7324,5595,8294,3012,8334,996,6233,3569,8351,3014,3020,8338,5594,11065,6197,1029,8354	CDKN2B,ANAPC5,H2AFZ,HIST1H4E,HIST1H3B,HIST1H3A,CDKN1A,HIST1H4D,HIST1H4H,IGFBP7,HIST4H4,CDKN2C,ANAPC1,RPS6KA2,CCNA2,HIST1H4B,HIST1H4C,FZR1,ANAPC11,ANAPC10,CDKN1B,HIST2H3D,ANAPC7,HIST1H2BH,UBB,MAPK7,UBE2D1,CDKN2D,STAT3,RELA,CDK6,HIST1H2AJ,HIST1H3F,HIST1H3C,UBA52,ANAPC2,CDC23,HIST1H4L,HIST1H3H,UBC,UBE2E1,MAPK3,HIST1H4I,HIST1H2AE,HIST1H2AC,CDC27,RPS27A,IL6,HIST1H3D,H2AFX,H3F3A,HIST2H2AC,MAPK1,UBE2C,RPS6KA3,CDKN2A,HIST1H3I
R-HSA-1538133	G0 and Early G1	0.000659954504641925	-7.32333965768047	25	18	0.00572155117609663	3146	8202	993,1875,4605,990,983,898,132660,7153,286826,890,1859,5111,1874,7027,3065,7029,91750,55957	CDC25A,E2F5,MYBL2,CDC6,CDK1,CCNE1,LIN54,TOP2A,LIN9,CCNA2,DYRK1A,PCNA,E2F4,TFDP1,HDAC1,TFDP2,LIN52,LIN37
R-HSA-2262749	Cellular response to hypoxia	0.000659954504641925	-7.32333965768047	25	18	0.00572155117609663	3146	8202	7323,2033,7311,6923,2034,9978,6921,7422,7316,1387,112398,6233,3091,8453,7322,112399,7321,7314	UBE2D3,EP300,UBA52,TCEB2,EPAS1,RBX1,TCEB1,VEGFA,UBC,CREBBP,EGLN2,RPS27A,HIF1A,CUL2,UBE2D2,EGLN3,UBE2D1,UBB
R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen	0.000659954504641925	-7.32333965768047	25	18	0.00572155117609663	3146	8202	7323,2033,7311,6923,2034,9978,6921,7422,7316,1387,112398,6233,3091,8453,7322,112399,7321,7314	UBE2D3,EP300,UBA52,TCEB2,EPAS1,RBX1,TCEB1,VEGFA,UBC,CREBBP,EGLN2,RPS27A,HIF1A,CUL2,UBE2D2,EGLN3,UBE2D1,UBB
R-HSA-1430728	Metabolism	0.000729578380710898	-7.22304375134425	1691	706	0.224411951684679	3146	8202	2632,5837,122481,10554,51251,64834,57019,9997,1387,6721,29785,7004,1785,9972,5499,31,4717,7311,7378,9200,377677,7263,5831,51170,5335,5719,6233,112812,226,211,9282,3706,54480,3795,4946,5214,10005,5689,4729,4329,30849,81579,5715,4507,783,10476,51582,9968,1152,10975,8694,178,51805,55967,5261,79902,2052,3156,91289,4860,594,4259,9807,5702,2194,2274,6604,3615,6616,8394,9517,2767,5685,1528,3931,8202,119391,509,3708,84649,4190,9440,11041,3073,686,2582,2033,2785,10858,55500,27158,1375,348995,347734,4258,5566,253558,10560,8895,10675,4709,8611,1854,65263,57122,10213,30833,2182,23171,8904,4704,2597,5208,3419,6303,6901,116228,4144,6392,221,9380,10166,4830,23097,10400,51363,25937,154141,5007,784,8566,9575,7172,7167,6526,2710,6391,1734,1723,2952,506,6120,10654,9491,9883,2937,5708,81857,3157,4710,10606,2232,117145,1349,7314,3613,6837,5694,3945,58478,26873,83401,5295,644,5710,5264,7316,57761,5091,51,10128,3098,57678,125061,11332,6723,1591,7381,6256,56922,162466,2131,3709,10423,6382,2752,4552,51166,6821,5034,5255,5296,5701,9061,23446,2108,23479,5901,8463,80205,5468,8612,10087,56267,3417,4953,1743,93100,641371,4257,9969,515,10327,2744,4047,3251,3638,27109,59345,200895,53343,266722,9942,5693,3028,51003,5713,427,1327,8702,51070,7084,8659,6945,112950,2356,6548,9217,5805,9443,5832,6309,224,5686,10478,23309,3612,11001,65985,50814,2181,262,8841,6342,7108,3295,5165,55697,5704,5226,3423,201562,9167,5337,498,79646,65220,8802,58472,7360,7357,9123,10162,64900,51079,5424,9453,2230,1592,4899,5164,3422,5687,9441,55229,10768,84188,326625,1491,10802,25796,7390,207,57704,1371,9631,514,8021,6487,50,5903,5743,22937,5709,22908,6482,129642,5716,682,285362,5297,353,375,3930,5501,340481,128,373156,4723,64768,2644,1337,215,3155,3320,10728,5106,2098,3101,3837,1373,5692,5465,1892,50640,5498,5467,23576,25874,221914,9,3614,79133,9469,64801,5223,2876,8310,9536,2653,11046,23511,79717,4712,283464,5565,54677,2782,51686,51380,5720,11145,25942,4942,2639,8898,9435,5519,1890,6484,55326,1490,5688,4714,8801,4199,1806,1836,4705,5360,55454,81929,2731,5160,2954,1841,9016,81894,79143,137964,2770,2531,23564,291,79017,25915,7298,7388,92126,3767,6341,8704,1329,3636,6240,9481,4697,51477,122622,374291,129401,2819,4724,137682,5298,6307,471,81490,5833,200576,2771,79888,4801,3425,8574,2222,5625,54704,1635,5315,5691,55361,847,51292,51422,50484,1633,51586,728294,8443,2643,254531,5224,7372,9611,55748,2101,1717,11165,9653,9374,6517,8826,7389,4711,5507,521,4706,3418,51302,2783,80308,64210,440,23054,9110,64428,230,115,377,4082,51727,6888,5256,2879,10484,1350,5163,53354,1353,55788,10025,3710,80724,253782,51181,2539,5500,9953,5711,9412,4719,593,10825,84245,8604,56894,113189,10682,10681,4695,55501,1384,1468,10434,57153,4833,85007,9896,2068,5469,56953,4696,51360,55856,5210,55163,5096,10678,8509,29968,56895,158,55331,7384,51647,166785,10427,51128,6448,36,518,8560,4947,4802,132,11285,51204,2180,57128,29796,7358,23568,91012,51241,1632,587,5906,5696,60496,2806,3291,3032,7385,231,3373,4715,4731,4700,9524,55588,4720,285521,10498,5567,1545,3704,8034,6241,10413,25870,857,25902,51660,23590,203,10855,8942,23530,5690,2717,10891,5705,4702,5700,8720,5528,9054,84706,80025,2170,127281,55034,50515,9871,84803,9429,435,808,6319,22856,79873,23165,1119,84246,5211,4952,2027,56474,8833,51085,27034,223,4522,516,85465,64802,5471,80150,51248,2948,79071,11163,6916,2629,26035,2778,131870,8396,2224,6566,23636,6907,9791,25974,5683,4191,57214,22949,2132,29079,1431,23198,8503,51074,113451,1727,11261,55217,84693,84274,27089,5695,8050,27010,4521,210,5706,8976,406,4694,8402,113612,9861,56848,4713,5723,22934,9391,8760,2026,55276,8480,8877,30,883,4520,3038,9632,253430,6472,5717,11164,1629,8398,6576,6667,7296,271,60481,5236,1024,51300,2729,7003,9551,92579,7175,80765,1351,1719,38,64788,2720,3420,5130	GBE1,PYGM,AK7,AGPAT1,NT5C3A,ELOVL1,CIAPIN1,SCO2,CREBBP,SREBF2,CYP2S1,TEAD4,DNM2,NUP153,PPP1CA,ACACA,NDUFC1,UBA52,UPP1,HACD1,CA13,TST,PYCR1,HSD17B11,PLCG1,PSMD13,RPS27A,FDX1L,ALDOA,ALAS1,MED14,ITPKA,CHPF2,KHK,OAZ1,PFKP,ACOT8,PSMB1,NDUFV2,ALDH6A1,PIK3R4,PLA2G12A,PSMD9,MTAP,CACNB2,ATP5H,AZIN1,MED12,CKB,UQCR11,DGAT1,AGL,COQ3,NDUFA12,PHKG2,NUP85,EPHX1,HMGCR,LMF2,PNP,BCKDHB,MGST3,IP6K1,PSMC3,FASN,FHL2,SMARCD3,IMPDH2,SNAP25,PIP5K1A,SPTLC2,GNA11,PSMA4,CYB5A,LCAT,NCOA3,GSTO2,ATP5C1,ITPR1,DGAT2,MDH1,MED17,B4GAT1,HEXA,BTD,GALE,EP300,GNG3,CYP46A1,ETNK1,NDOR1,CPT1B,NUP43,SLC35B2,MGST2,PRKACA,LCLAT1,SLC19A2,CPNE3,CSPG5,NDUFB3,PLPP1,DUT,PYCRL,NUP107,PSMD14,NT5C,ACSL4,GPD1L,CPNE1,NDUFA9,GAPDH,PFKFB2,IDH3A,SAT1,TAZ,COX20,MAT2A,SDHD,ALDH3B1,GRHPR,SLC25A15,NME1,CDK19,PEMT,CHST15,WWTR1,MBOAT1,OSBP,CACNB3,PDXK,CLOCK,TPMT,TPI1,SLC5A3,GK,SDHC,DIO2,DHODH,GSTT1,ATP5B,RPE,PMVK,PSMF1,POM121,GSS,PSMD2,MED25,HMGCS1,NDUFB4,PAICS,FDXR,THEM4,COX7B,UBB,IMPA2,MED22,PSMB6,LDHB,ENOPH1,OPLAH,ELOVL3,PIK3R1,BLVRA,PSMD4,PHYH,UBC,TRIB3,PC,ACOX1,LRPPRC,HK1,GPAM,AFMID,ACOT7,SRM,CYP24A1,UQCRB,RXRA,MCCC1,PHOSPHO1,EXT1,ITPR2,CDIPT,SDC1,GLUL,MTRR,AADAT,SUOX,P4HB,PHKA1,PIK3R2,PSMC2,PAPSS1,SLC44A1,ETFA,ISCU,RAN,TEAD2,CHD9,PPARG,PLPP2,COL4A3BP,CCBL2,IDH1,ODC1,DLST,NAPRT,ACOT1,MGST1,MED13,ATP5F1,AKR1A1,GLS,LSS,HPRT1,INSIG1,ATP5S,GNB4,DHFRL1,NUDT9,HS6ST3,XYLB,PSMB5,HSD17B10,MED31,PSMD7,ASAH1,COX4I1,B4GALT4,NOSIP,TK2,ALDH4A1,MLX,MED8,FPGS,SLC9A1,VAPB,PTS,MED7,ALDH18A1,SC5D,ALDH3A2,PSMA5,SLC25A17,SIN3B,IMPA1,SLC27A2,AACS,NSDHL,ACSL3,AMD1,HDAC3,SCP2,TM7SF2,HSD17B4,PDK3,VAC14,PSMC4,PGD,IDS,HACD2,COX7A2L,PLD1,ATP5A1,PANK3,NADK,SUCLG1,SQRDL,UGP2,UGCG,SLC16A3,LPCAT3,LPIN3,NDUFA13,POLD1,GGPS1,FDX1,CYP26A1,NRF1,PDK2,IDI1,PSMA6,MED26,PANK4,AHCYL1,FAR1,MMAB,CTH,SEC24A,PGLS,UROS,AKT1,GBA2,CPOX,NUP155,ATP5E,NUP214,ST3GAL3,ACO2,RANBP2,PTGS2,SCAP,PSMD3,SACM1L,ST3GAL1,MBOAT2,PSMD10,BSG,SUMF1,PI4KA,APRT,ARF1,LBR,PPP1CC,ZDHHC21,ADH5,GSTK1,NDUFV1,IPPK,GCHFR,COX6A1,ABCD1,HMGCL,HSP90AA1,PTGES3,PCK2,ESD,HK3,KPNB1,CPS1,PSMB4,PPARA,ECHS1,PNPLA8,PPOX,PPARD,DDAH1,MPC2,GPC2,NAT1,IMPDH1,NDUFAF5,CHST3,ARV1,PGAM1,GPX1,ACOX3,PTGES,GCSH,SLC35D2,NUP188,PPCS,NDUFB6,GXYLT1,PRKAB2,CROT,GNB1,OAZ3,CSAD,PSME1,PLA2G16,SIN3A,OAT,GCDH,MTMR2,CHST2,PPP2R1B,TYMP,ST3GAL4,AGPAT5,CTGF,PSMA7,NDUFB8,SUCLG2,ME1,DPYD,SLC26A2,NDUFA10,PLTP,CSGALNACT2,SEH1L,GLDC,PDHA1,GSTZ1,DTYMK,SLC25A14,SLC25A28,MBOAT7,GPAT4,GNAI1,KDSR,DDAH2,SLC25A4,GGCT,NDUFAF3,TYMS,UQCRH,DSEL,KCNJ11,SCO1,B4GALT2,COX5B,INPPL1,RRM1,SLC25A27,NDUFA4,ISYNA1,ADSSL1,NDUFS7,NUP35,GPD1,NDUFS4,NDUFAF6,PI4KB,MSMO1,ATIC,PTDSS2,PCYT2,PIKFYVE,GNAI2,LPCAT1,NFYB,IDUA,AKR7A2,FDFT1,PRODH,PDP1,DCTD,PKM,PSMB3,PI4K2A,CAT,GMPR2,PRKAG2,RRM2B,DCK,MED15,D2HGDH,GNPAT,GCH1,LPCAT4,PGAM2,UMPS,NCOR1,CNDP2,ESRRA,DHCR7,NUDT3,HS2ST1,PPT2,SLC2A4,IQGAP1,UROD,NDUFB5,PPP1R3C,ATP5I,NDUFAB1,IDH2,CYP39A1,GNB2,FLAD1,MMS19,ASNS,NCOA6,MTMR4,NARFL,ALDOC,ADCY9,ARF3,MARCKS,CMPK1,TALDO1,PHKA2,GPX4,SEC23A,COX7C,PDK1,PANK1,COX11,LMBRD1,MED16,ITPR3,ACAD10,CERS6,DCXR,G6PD,PPP1CB,HS3ST3B1,PSMD5,MED21,NDUFS1,BCKDHA,NEU3,MRI1,SLC25A12,AGPAT3,CHST14,EBP,GNB5,NDUFA2,CHST12,CRAT,SLC25A10,LYPLA1,SLC44A2,NME4,PHYKPL,FIG4,ERCC2,MED1,NT5M,NDUFA3,MBTPS2,ACOT13,PFKFB4,PNPO,PCCB,B3GNT2,NDST2,PSAT1,AGPAT4,ADSL,ACER3,UQCRC1,FAM96B,MMAA,SEC24B,SAR1B,SGSH,ACADSB,ATP5G3,DEGS1,OAZ2,NFYC,ADK,B4GALT7,TACO1,ACSL1,LYRM4,UQCR10,UGDH,ARL2BP,CERS5,COX16,ECI1,BCAT2,RAP1A,PSMB8,AASDHPPT,GOT2,HSD11B2,HADHB,UQCRC2,AKR1B1,HYAL1,NDUFB9,NDUFV3,NDUFA6,TECR,MED29,NDUFS2,COX18,CARM1,PRKACB,CYP1B1,ITPA,SLC25A16,RRM2,YAP1,SUMF2,CAV1,MTHFD1L,MPC1,PDSS1,AK1,HPSE,KYNU,NNT,PSMB2,GLA,PPARGC1A,PSMC5,NDUFA8,PSMC1,MBTPS1,PPP2R5D,NFS1,GPT2,PANK2,FABP3,FAM213B,MOCOS,CHST11,SEC24D,GPAT3,ABCG2,ASL,CALM3,SCD,CHSY1,NUDT18,NUP205,CHKA,MED10,PFKL,OCRL,ENO3,CTPS2,GMPS,MLXIPL,ACAD8,ALDH9A1,MTHFD1,ATP5G1,EPT1,NMNAT1,PPAT,ASRGL1,PDZD11,GSTM4,ELOVL6,NUDT4,TBXAS1,GBA,GLCE,GNAS,NUDT16,PIP4K2B,FDPS,SLC16A1,NUP62,TBL1X,PTDSS1,MMACHC,PSMA2,MDH2,CEMIP,PTGR1,EXT2,MED4,CS,PSME4,PIK3R3,APIP,AZIN2,CYB5R3,CHP1,TMLHE,MCEE,COQ5,UQCRQ,PSMB7,PDHX,TPK1,NUDT1,ALAD,PSMC6,WASL,ARNTL,NDUFA1,SLC25A11,CYP2U1,PSMD6,SPHK2,NDUFB7,PSPH,RPIA,CIAO1,CDS2,ENO2,PGM2,RAE1,SPHK1,ACAA1,CCBL1,MTF1,HAS3,SEC24C,IPMK,SHMT2,PSMD11,NUDT5,DBT,PLA2G6,SLC25A1,SP1,TXNRD1,AMPD2,ELOVL5,PGM1,CDK8,TIMMDC1,GCLC,TEAD1,ATP5J2,G6PC3,TPR,STARD5,COX8A,DHFR,ACAT1,LMF1,GLB1,IDH3B,PCYT1A
R-HSA-76061	RNA Polymerase III Transcription Initiation From Type 1 Promoter	0.000737587391451842	-7.21212597988665	27	19	0.00603941513032422	3146	8202	2976,2975,5441,5440,9328,6908,171568,55814,84265,2971,51728,11128,5434,9329,27297,2972,55703,9533,10621	GTF3C2,GTF3C1,POLR2L,POLR2K,GTF3C5,TBP,POLR3H,BDP1,POLR3GL,GTF3A,POLR3K,POLR3A,POLR2E,GTF3C4,CRCP,BRF1,POLR3B,POLR1C,POLR3F
R-HSA-15869	Metabolism of nucleotides	0.000796102584352904	-7.13578250560833	82	46	0.0146217418944692	3146	8202	122481,6240,1723,353,51251,122622,79873,7084,1890,10606,471,1854,56474,4833,8833,30833,11164,1806,51727,56953,7296,271,1841,4860,3704,5471,7378,158,6241,1635,3615,847,4521,131870,3251,51292,203,4830,50484,1633,7298,3614,7372,132,53343,2876	AK7,RRM1,DHODH,APRT,NT5C3A,ADSSL1,NUDT18,TK2,TYMP,PAICS,ATIC,DUT,CTPS2,NME4,GMPS,NT5C,NUDT5,DPYD,CMPK1,NT5M,TXNRD1,AMPD2,DTYMK,PNP,ITPA,PPAT,UPP1,ADSL,RRM2,DCTD,IMPDH2,CAT,NUDT1,NUDT16,HPRT1,GMPR2,AK1,NME1,RRM2B,DCK,TYMS,IMPDH1,UMPS,ADK,NUDT9,GPX1
R-HSA-400253	Circadian Clock	0.000797295391967117	-7.1342853180196	63	37	0.0117609663064209	3146	8202	2033,6256,8454,5501,1387,23054,1408,5499,150094,7314,8204,1407,1386,5469,10498,23411,80205,7311,2908,1454,8841,5465,6604,4209,7316,6233,3091,5187,406,5500,9611,6907,1628,10891,9575,25819,23373	EP300,RXRA,CUL1,PPP1CC,CREBBP,NCOA6,CRY2,PPP1CA,SIK1,UBB,NRIP1,CRY1,ATF2,MED1,CARM1,SIRT1,CHD9,UBA52,NR3C1,CSNK1E,HDAC3,PPARA,SMARCD3,MEF2D,UBC,RPS27A,HIF1A,PER1,ARNTL,PPP1CB,NCOR1,TBL1X,DBP,PPARGC1A,CLOCK,NOCT,CRTC1
R-HSA-381070	IRE1alpha activates chaperones	0.000899966150848609	-7.01315340551546	55	33	0.0104895104895105	3146	8202	3068,118,64061,5611,7095,11231,4000,6745,1200,6464,9695,56005,10130,9114,10106,55176,10113,2673,7709,2931,6734,10525,84447,27230,22872,10897,29927,9797,7466,2081,7494,439,116138	HDGF,ADD1,TSPYL2,DNAJC3,SEC62,SEC63,LMNA,SSR1,TPP1,SHC1,EDEM1,MYDGF,PDIA6,ATP6V0D1,CTDSP2,SEC61A2,PREB,GFPT1,ZBTB17,GSK3A,SRPR,HYOU1,SYVN1,SERP1,SEC31A,YIF1A,SEC61A1,TATDN2,WFS1,ERN1,XBP1,ASNA1,KLHDC3
R-HSA-381038	XBP1(S) activates chaperone genes	0.000921944261373041	-6.98902579027735	53	32	0.0101716465352829	3146	8202	7709,2673,6734,3068,2931,118,64061,5611,7095,10525,84447,11231,27230,4000,6745,10897,22872,1200,6464,29927,9695,7466,9797,7494,439,56005,10130,9114,10106,116138,55176,10113	ZBTB17,GFPT1,SRPR,HDGF,GSK3A,ADD1,TSPYL2,DNAJC3,SEC62,HYOU1,SYVN1,SEC63,SERP1,LMNA,SSR1,YIF1A,SEC31A,TPP1,SHC1,SEC61A1,EDEM1,WFS1,TATDN2,XBP1,ASNA1,MYDGF,PDIA6,ATP6V0D1,CTDSP2,KLHDC3,SEC61A2,PREB
R-HSA-2028269	Signaling by Hippo	0.000955643621059443	-6.95312549573168	20	15	0.00476795931341386	3146	8202	51421,836,261734,154810,6788,25937,23286,10413,9113,7082,60485,7531,55233,1856,6789	AMOTL2,CASP3,NPHP4,AMOTL1,STK3,WWTR1,WWC1,YAP1,LATS1,TJP1,SAV1,YWHAE,MOB1A,DVL2,STK4
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	0.000959744914084338	-6.94884302330622	37	24	0.00762873490146217	3146	8202	7353,5984,5983,7311,10714,5982,5424,10459,7316,9636,5980,5111,9768,9246,5426,5427,6233,7706,5981,7314,5429,51455,5425,124739	UFD1L,RFC4,RFC3,UBA52,POLD3,RFC2,POLD1,MAD2L2,UBC,ISG15,REV3L,PCNA,KIAA0101,UBE2L6,POLE,POLE2,RPS27A,TRIM25,RFC1,UBB,POLH,REV1,POLD2,USP43
R-HSA-421837	Clathrin derived vesicle budding	0.00105492944767511	-6.85428138853189	70	40	0.0127145581691036	3146	8202	6272,8673,25977,2495,375,9685,7164,8729,7037,81567,4952,8907,1785,8906,130340,1362,3482,2512,11154,54885,6643,8905,10717,8546,7163,9179,26258,6810,23431,55330,8301,8773,1213,2580,164,8775,388552,5878,27131,23557	SORT1,VAMP8,NECAP1,FTH1,ARF1,CLINT1,TPD52L1,GBF1,TFRC,TXNDC5,OCRL,AP1M1,DNM2,AP1G2,AP1S3,CPD,IGF2R,FTL,AP4S1,TBC1D8B,SNX2,AP1S2,AP4B1,AP3B1,TPD52,AP4M1,BLOC1S6,STX4,AP4E1,BLOC1S4,PICALM,SNAP23,CLTC,GAK,AP1G1,NAPA,BLOC1S3,RAB5C,SNX5,SNAPIN
R-HSA-199992	trans-Golgi Network Vesicle Budding	0.00105492944767511	-6.85428138853189	70	40	0.0127145581691036	3146	8202	6272,8673,25977,2495,375,9685,7164,8729,7037,81567,4952,8907,1785,8906,130340,1362,3482,2512,11154,54885,6643,8905,10717,8546,7163,9179,26258,6810,23431,55330,8301,8773,1213,2580,164,8775,388552,5878,27131,23557	SORT1,VAMP8,NECAP1,FTH1,ARF1,CLINT1,TPD52L1,GBF1,TFRC,TXNDC5,OCRL,AP1M1,DNM2,AP1G2,AP1S3,CPD,IGF2R,FTL,AP4S1,TBC1D8B,SNX2,AP1S2,AP4B1,AP3B1,TPD52,AP4M1,BLOC1S6,STX4,AP4E1,BLOC1S4,PICALM,SNAP23,CLTC,GAK,AP1G1,NAPA,BLOC1S3,RAB5C,SNX5,SNAPIN
R-HSA-202424	Downstream TCR signaling	0.00112756945639194	-6.78769088636332	96	52	0.0165289256198347	3146	8202	23291,5689,5693,5683,5713,5716,8454,1147,5720,5715,9491,5708,5696,5687,5688,3551,5296,5701,23198,10213,5717,7321,7314,5970,5686,5694,5170,7311,5692,5295,5702,5695,10892,7335,5710,5685,5691,7316,5704,997,5719,23118,6233,5706,5709,7322,5690,5705,9861,5700,7334,5711	FBXW11,PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,CUL1,CHUK,PSME1,PSMD9,PSMF1,PSMD2,PSMB8,PSMA6,PSMA7,IKBKB,PIK3R2,PSMC2,PSME4,PSMD14,PSMD11,UBE2D1,UBB,RELA,PSMA5,PSMB6,PDPK1,UBA52,PSMB4,PIK3R1,PSMC3,PSMB7,MALT1,UBE2V1,PSMD4,PSMA4,PSMB3,UBC,PSMC4,CDC34,PSMD13,TAB2,RPS27A,PSMC6,PSMD3,UBE2D2,PSMB2,PSMC5,PSMD6,PSMC1,UBE2N,PSMD5
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	0.00114238572838594	-6.77463645911635	107	57	0.0181182453909727	3146	8202	3015,5440,8367,6908,2071,8358,8350,404672,25942,7270,23378,8360,8365,121504,79595,9014,8366,10849,8932,8364,653604,8345,2068,84172,30834,64425,8331,8819,23309,8968,8352,23411,5441,11176,79101,51742,8368,8357,29115,221830,8294,7343,4331,3012,8334,8351,5434,3014,3065,10284,9533,8467,3020,8338,6839,3066,8354	H2AFZ,POLR2K,HIST1H4E,TBP,ERCC3,HIST1H3B,HIST1H3A,GTF2H5,SIN3A,TTF1,RRP8,HIST1H4D,HIST1H4H,HIST4H4,SAP130,TAF1B,HIST1H4B,CD3EAP,MBD2,HIST1H4C,HIST2H3D,HIST1H2BH,ERCC2,POLR1B,ZNRD1,POLR1E,HIST1H2AJ,SAP30,SIN3B,HIST1H3F,HIST1H3C,SIRT1,POLR2L,BAZ2A,TAF1D,ARID4B,HIST1H4L,HIST1H3H,SAP30BP,TWISTNB,HIST1H4I,UBTF,MNAT1,HIST1H2AE,HIST1H2AC,HIST1H3D,POLR2E,H2AFX,HDAC1,SAP18,POLR1C,SMARCA5,H3F3A,HIST2H2AC,SUV39H1,HDAC2,HIST1H3I
R-HSA-73854	RNA Polymerase I Promoter Clearance	0.00114238572838594	-6.77463645911635	107	57	0.0181182453909727	3146	8202	57504,3015,5440,8367,6908,2071,8358,8350,404672,7270,8360,8365,121504,54815,54700,9014,8366,10849,8932,8364,653604,1108,8345,2068,84172,30834,64425,8331,57459,8968,8352,5441,2648,5931,79101,9219,8368,8357,53615,221830,5595,8294,7343,4331,3012,8334,2074,1107,8351,5434,3014,3065,9533,3020,8338,3066,8354	MTA3,H2AFZ,POLR2K,HIST1H4E,TBP,ERCC3,HIST1H3B,HIST1H3A,GTF2H5,TTF1,HIST1H4D,HIST1H4H,HIST4H4,GATAD2A,RRN3,TAF1B,HIST1H4B,CD3EAP,MBD2,HIST1H4C,HIST2H3D,CHD4,HIST1H2BH,ERCC2,POLR1B,ZNRD1,POLR1E,HIST1H2AJ,GATAD2B,HIST1H3F,HIST1H3C,POLR2L,KAT2A,RBBP7,TAF1D,MTA2,HIST1H4L,HIST1H3H,MBD3,TWISTNB,MAPK3,HIST1H4I,UBTF,MNAT1,HIST1H2AE,HIST1H2AC,ERCC6,CHD3,HIST1H3D,POLR2E,H2AFX,HDAC1,POLR1C,H3F3A,HIST2H2AC,HDAC2,HIST1H3I
R-HSA-113507	E2F-enabled inhibition of pre-replication complex formation	0.00116947338493418	-6.751201729844	10	9	0.00286077558804832	3146	8202	993,4999,5000,23595,891,983,23594,5001,84515	CDC25A,ORC2,ORC4,ORC3,CCNB1,CDK1,ORC6,ORC5,MCM8
R-HSA-72306	tRNA processing	0.00119350685906175	-6.73085936518745	94	51	0.0162110616656071	3146	8202	348180,23511,8480,55621,10978,8270,10775,348995,54517,79074,79042,9883,23165,129401,10556,127253,29894,54482,57122,51493,81605,9972,5901,93587,79902,81929,79691,4234,54913,54802,54888,55253,9631,51504,8021,11260,7175,5903,339487,51002,10785,23536,54901,1478,23636,80324,283742,80746,90353,116461,115708	CTU2,NUP188,RAE1,TRMT1,CLP1,LAGE3,POP4,NUP43,PUS7,C2orf49,TSEN34,POM121,NUP205,NUP35,RPP30,TYW3,CPSF1,TRMT13,NUP107,RTCB,URM1,NUP153,RAN,TRMT10A,NUP85,SEH1L,QTRTD1,METTL1,RPP25,TRIT1,NSUN2,TYW1,NUP155,TRMT112,NUP214,XPOT,TPR,RANBP2,ZBTB8OS,TPRKB,WDR4,ADAT1,CDKAL1,CSTF2,NUP62,PUS1,FAM98B,TSEN2,CTU1,TSEN15,TRMT61A
R-HSA-3214841	PKMTs methylate histone lysines	0.00119838509462567	-6.72678038300758	64	37	0.0117609663064209	3146	8202	84661,55904,8367,23512,55729,8358,8350,54904,11091,5929,8360,8365,2122,121504,2146,83852,79723,8366,387893,8364,653604,9070,4297,8968,8352,121536,5931,7468,56950,8368,8357,8294,8351,9757,6839,9869,8354	DPY30,KMT2E,HIST1H4E,SUZ12,ATF7IP,HIST1H3B,HIST1H3A,WHSC1L1,WDR5,RBBP5,HIST1H4D,HIST1H4H,MECOM,HIST4H4,EZH2,SETDB2,SUV39H2,HIST1H4B,KMT5A,HIST1H4C,HIST2H3D,ASH2L,KMT2A,HIST1H3F,HIST1H3C,AEBP2,RBBP7,WHSC1,SMYD2,HIST1H4L,HIST1H3H,HIST1H4I,HIST1H3D,KMT2B,SUV39H1,SETDB1,HIST1H3I
R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	0.00123877413364762	-6.69363299025143	15	12	0.00381436745073109	3146	8202	23658,11157,1656,196513,51690,57819,23644,25804,54464,27257,219988,80153	LSM5,LSM6,DDX6,DCP1B,LSM7,LSM2,EDC4,LSM4,XRN1,LSM1,PATL1,EDC3
R-HSA-69298	Association of licensing factors with the pre-replicative complex	0.00123877413364762	-6.69363299025143	15	12	0.00381436745073109	3146	8202	51053,4999,7311,5000,6233,5001,1871,990,7314,23595,1870,7316	GMNN,ORC2,UBA52,ORC4,RPS27A,ORC5,E2F3,CDC6,UBB,ORC3,E2F2,UBC
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	0.00126648891985481	-6.671506837195	168	84	0.0267005721551176	3146	8202	23291,685,7249,2475,5683,2064,8454,1147,5720,1026,4193,5696,5687,5688,3551,5296,5701,23198,10213,1027,8503,253260,5970,10818,64223,7311,2931,207,208,842,5695,2260,8660,2534,5719,5706,6233,5709,4254,2932,5690,5705,9861,4343,5700,2549,5711,5689,23112,5693,5966,5713,79109,5716,5715,2309,9491,5708,117145,5781,5717,2065,7314,5686,5694,6199,5170,4303,5692,3164,5295,5702,10892,5710,5685,5691,7316,5704,2885,57761,2069,4793,3265,192669	FBXW11,BTC,TSC2,MTOR,PSMA2,ERBB2,CUL1,CHUK,PSME1,CDKN1A,MDM2,PSMB8,PSMA6,PSMA7,IKBKB,PIK3R2,PSMC2,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,RELA,FRS2,MLST8,UBA52,GSK3A,AKT1,AKT2,CASP9,PSMB7,FGFR1,IRS2,FYN,PSMD13,PSMC6,RPS27A,PSMD3,KITLG,GSK3B,PSMB2,PSMC5,PSMD6,MOV10,PSMC1,GAB1,PSMD5,PSMB1,TNRC6B,PSMB5,REL,PSMD7,MAPKAP1,PSMD10,PSMD9,FOXO3,PSMF1,PSMD2,THEM4,PTPN11,PSMD11,ERBB3,UBB,PSMA5,PSMB6,RPS6KB2,PDPK1,FOXO4,PSMB4,NR4A1,PIK3R1,PSMC3,MALT1,PSMD4,PSMA4,PSMB3,UBC,PSMC4,GRB2,TRIB3,EREG,NFKBIB,HRAS,AGO3
R-HSA-70326	Glucose metabolism	0.00131859671491352	-6.63118720263239	77	43	0.0136681500317864	3146	8202	2632,2026,7360,55276,5837,4191,8604,5507,808,5566,5519,2806,5211,5255,230,2027,1468,5106,5256,7314,3101,178,5261,5567,6576,5210,5236,7311,2597,5208,5315,7316,5091,6233,226,8402,4190,5224,3098,5223,5528,7167,5214	GBE1,ENO2,UGP2,PGM2,PYGM,MDH2,SLC25A12,PPP1R3C,CALM3,PRKACA,PPP2R1B,GOT2,PFKL,PHKA1,ALDOC,ENO3,SLC25A10,PCK2,PHKA2,UBB,HK3,AGL,PHKG2,PRKACB,SLC25A1,PFKFB4,PGM1,UBA52,GAPDH,PFKFB2,PKM,UBC,PC,RPS27A,ALDOA,SLC25A11,MDH1,PGAM2,HK1,PGAM1,PPP2R5D,TPI1,PFKP
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	0.00133616748913576	-6.61794984560578	90	49	0.0155753337571519	3146	8202	11258,1781,10142,11116,261734,5116,79867,80321,5048,10383,8655,54903,7531,5566,8766,55142,9793,9702,4218,79598,85302,80184,55835,84131,10733,4751,3320,80254,27077,1454,55755,121441,117177,22994,79959,79600,983,7532,132320,5108,4957,10806,8481,146057,54820,55125,7840,4867,203068	DCTN3,DYNC1I2,AKAP9,FGFR1OP,NPHP4,PCNT,TCTN2,CEP70,PAFAH1B1,TUBB4B,DYNLL1,MKS1,YWHAE,PRKACA,RAB11A,HAUS2,CKAP5,CEP57,RAB8A,CEP97,FBF1,CEP290,CENPJ,CEP78,PLK4,NEK2,HSP90AA1,CEP63,B9D1,CSNK1E,CDK5RAP2,NEDD1,RAB3IP,CEP131,CEP76,TCTN1,CDK1,YWHAG,SCLT1,PCM1,ODF2,SDCCAG8,OFD1,TTBK2,NDE1,CEP192,ALMS1,NPHP1,TUBB
R-HSA-76066	RNA Polymerase III Transcription Initiation From Type 2 Promoter	0.00137761007545858	-6.587405110541	26	18	0.00572155117609663	3146	8202	2976,2975,5441,5440,9328,6908,171568,55814,84265,51728,11128,9329,5434,27297,2972,55703,9533,10621	GTF3C2,GTF3C1,POLR2L,POLR2K,GTF3C5,TBP,POLR3H,BDP1,POLR3GL,POLR3K,POLR3A,GTF3C4,POLR2E,CRCP,BRF1,POLR3B,POLR1C,POLR3F
R-HSA-380287	Centrosome maturation	0.00145767383773781	-6.5309133756767	73	41	0.0130324221233312	3146	8202	11258,1781,10142,11116,5116,80321,10383,5048,8655,7531,891,984,5566,55142,9793,9702,80184,55835,84131,85378,10733,4751,3320,80254,1454,55755,114791,121441,79959,22994,983,7532,4926,5108,4957,10806,8481,54820,55125,7840,203068	DCTN3,DYNC1I2,AKAP9,FGFR1OP,PCNT,CEP70,TUBB4B,PAFAH1B1,DYNLL1,YWHAE,CCNB1,CDK11B,PRKACA,HAUS2,CKAP5,CEP57,CEP290,CENPJ,CEP78,TUBGCP6,PLK4,NEK2,HSP90AA1,CEP63,CSNK1E,CDK5RAP2,TUBGCP5,NEDD1,CEP76,CEP131,CDK1,YWHAG,NUMA1,PCM1,ODF2,SDCCAG8,OFD1,NDE1,CEP192,ALMS1,TUBB
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	0.00145767383773781	-6.5309133756767	73	41	0.0130324221233312	3146	8202	11258,1781,10142,11116,5116,80321,10383,5048,8655,7531,891,984,5566,55142,9793,9702,80184,55835,84131,85378,10733,4751,3320,80254,1454,55755,114791,121441,79959,22994,983,7532,4926,5108,4957,10806,8481,54820,55125,7840,203068	DCTN3,DYNC1I2,AKAP9,FGFR1OP,PCNT,CEP70,TUBB4B,PAFAH1B1,DYNLL1,YWHAE,CCNB1,CDK11B,PRKACA,HAUS2,CKAP5,CEP57,CEP290,CENPJ,CEP78,TUBGCP6,PLK4,NEK2,HSP90AA1,CEP63,CSNK1E,CDK5RAP2,TUBGCP5,NEDD1,CEP76,CEP131,CDK1,YWHAG,NUMA1,PCM1,ODF2,SDCCAG8,OFD1,NDE1,CEP192,ALMS1,TUBB
R-HSA-76071	RNA Polymerase III Transcription Initiation From Type 3 Promoter	0.00147226297148569	-6.52095462552418	28	19	0.00603941513032422	3146	8202	5441,5440,6908,171568,55814,5451,84265,7702,6618,51728,11128,5434,27297,6619,55703,9533,10302,6617,10621	POLR2L,POLR2K,TBP,POLR3H,BDP1,POU2F1,POLR3GL,ZNF143,SNAPC2,POLR3K,POLR3A,POLR2E,CRCP,SNAPC3,POLR3B,POLR1C,SNAPC5,SNAPC1,POLR3F
R-HSA-5218920	VEGFR2 mediated vascular permeability	0.00147226297148569	-6.52095462552418	28	19	0.00603941513032422	3146	8202	5170,3728,207,2475,208,1495,7410,5879,79109,808,857,57761,1499,117145,5062,253260,1500,3320,64223	PDPK1,JUP,AKT1,MTOR,AKT2,CTNNA1,VAV2,RAC1,MAPKAP1,CALM3,CAV1,TRIB3,CTNNB1,THEM4,PAK2,RICTOR,CTNND1,HSP90AA1,MLST8
R-HSA-75153	Apoptotic execution  phase	0.00148255504947129	-6.51398829491753	52	31	0.00985378258105531	3146	8202	836,3146,118,63967,1676,839,28988,324,7082,3008,22985,5747,5339,1832,10134,329,4000,2934,840,2339,1499,51765,1829,5062,3009,3148,6093,841,3837,4137,6709	CASP3,HMGB1,ADD1,CLSPN,DFFA,CASP6,DBNL,APC,TJP1,HIST1H1E,ACIN1,PTK2,PLEC,DSP,BCAP31,BIRC2,LMNA,GSN,CASP7,FNTA,CTNNB1,STK26,DSG2,PAK2,HIST1H1B,HMGB2,ROCK1,CASP8,KPNB1,MAPT,SPTAN1
R-HSA-74752	Signaling by Insulin receptor	0.00151364322115997	-6.49323580486824	304	142	0.0451366815003179	3146	8202	7249,4763,5565,5786,92335,537,5720,5519,57521,5906,5696,5688,5296,5701,6194,5494,1977,529,10818,64223,7311,9978,208,5571,283455,6009,1981,5719,6233,4296,10325,4254,5527,5690,527,5705,409,5700,2549,5528,8992,58528,5689,5693,5562,5245,30849,8649,5713,808,10256,5715,1847,23545,51606,9114,5686,5702,5908,8437,5605,5685,5691,5921,5704,3643,51422,389541,2069,200734,685,10142,161742,9462,5683,523,2475,5894,8826,5037,5604,2064,64121,5687,6464,6711,23198,10213,7414,9550,207,8452,5695,1742,535,1846,2260,8660,817,5529,2534,10312,5706,5709,80824,1978,6198,5536,9861,5594,5711,1844,673,5716,9491,10542,5708,117145,5781,3717,5717,2065,7314,6709,1843,5694,5170,5692,6654,5295,5747,5710,7316,5595,2885,57761,51382,84078,152559,84292,528,3265	TSC2,NF1,PRKAB2,PTPRA,STRADA,ATP6AP1,PSME1,PPP2R1B,RPTOR,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,RPS6,PPM1A,EIF4E,ATP6V1E1,FRS2,MLST8,UBA52,RBX1,AKT2,PRKAG1,KSR2,RHEB,EIF4G1,PSMD13,RPS27A,MAP3K11,RRAGB,KITLG,PPP2R5C,PSMB2,ATP6V0C,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,ATP6V0E1,RRAGD,PSMB1,PSMB5,PRKAA1,PHB,PIK3R4,LAMTOR3,PSMD7,CALM3,CNKSR1,PSMD9,DUSP5,ATP6V0A2,ATP6V1H,ATP6V0D1,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,INSR,PRKAG2,LAMTOR4,EREG,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,ATP6V1A,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,RRAGC,PSMA6,SHC1,SPTBN1,PSME4,PSMD14,VCL,ATP6V1G1,AKT1,CUL3,PSMB7,DLG4,ATP6V0A1,DUSP4,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,TCIRG1,PSMC6,PSMD3,DUSP16,EIF4EBP1,RPS6KB1,PPP5C,PSMD6,MAPK1,PSMD5,DUSP2,BRAF,PSMD10,PSMF1,LAMTOR5,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,SPTAN1,DUSP1,PSMB6,PDPK1,PSMB4,SOS1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,ATP6V1D,KBTBD7,PAQR3,WDR83,ATP6V1C1,HRAS
R-HSA-937061	TRIF-mediated TLR3/TLR4 signaling	0.00153554065384217	-6.47887274247024	97	52	0.0165289256198347	3146	8202	5599,7323,23291,3146,257397,5604,1660,8454,4205,1147,3661,9252,329,5519,5606,466,6196,10010,3551,5601,5781,4791,841,7314,5598,7321,1386,5970,29110,7311,5609,330,7867,7335,1846,7316,5595,10392,23118,6233,1845,5608,7322,148022,4793,10454,79155,5594,5528,6416,7334,6197	MAPK8,UBE2D3,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,IRF3,RPS6KA5,BIRC2,PPP2R1B,MAP2K3,ATF1,RPS6KA2,TANK,IKBKB,MAPK9,PTPN11,NFKB2,CASP8,UBB,MAPK7,UBE2D1,ATF2,RELA,TBK1,UBA52,MAP2K7,BIRC3,MAPKAPK3,UBE2V1,DUSP4,UBC,MAPK3,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,UBE2D2,TICAM1,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,MAP2K4,UBE2N,RPS6KA3
R-HSA-166166	MyD88-independent TLR3/TLR4 cascade	0.00153554065384217	-6.47887274247024	97	52	0.0165289256198347	3146	8202	5599,7323,23291,3146,257397,5604,1660,8454,4205,1147,3661,9252,329,5519,5606,466,6196,10010,3551,5601,5781,4791,841,7314,5598,7321,1386,5970,29110,7311,5609,330,7867,7335,1846,7316,5595,10392,23118,6233,1845,5608,7322,148022,4793,10454,79155,5594,5528,6416,7334,6197	MAPK8,UBE2D3,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,IRF3,RPS6KA5,BIRC2,PPP2R1B,MAP2K3,ATF1,RPS6KA2,TANK,IKBKB,MAPK9,PTPN11,NFKB2,CASP8,UBB,MAPK7,UBE2D1,ATF2,RELA,TBK1,UBA52,MAP2K7,BIRC3,MAPKAPK3,UBE2V1,DUSP4,UBC,MAPK3,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,UBE2D2,TICAM1,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,MAP2K4,UBE2N,RPS6KA3
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	0.00153554065384217	-6.47887274247024	97	52	0.0165289256198347	3146	8202	5599,7323,23291,3146,257397,5604,1660,8454,4205,1147,3661,9252,329,5519,5606,466,6196,10010,3551,5601,5781,4791,841,7314,5598,7321,1386,5970,29110,7311,5609,330,7867,7335,1846,7316,5595,10392,23118,6233,1845,5608,7322,148022,4793,10454,79155,5594,5528,6416,7334,6197	MAPK8,UBE2D3,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,IRF3,RPS6KA5,BIRC2,PPP2R1B,MAP2K3,ATF1,RPS6KA2,TANK,IKBKB,MAPK9,PTPN11,NFKB2,CASP8,UBB,MAPK7,UBE2D1,ATF2,RELA,TBK1,UBA52,MAP2K7,BIRC3,MAPKAPK3,UBE2V1,DUSP4,UBC,MAPK3,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,UBE2D2,TICAM1,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,MAP2K4,UBE2N,RPS6KA3
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	0.00159014507745519	-6.44393002322994	17	13	0.00413223140495868	3146	8202	811,9761,5589,51009,9695,80267,7841,2923,55757,56886,84447,55741,821	CALR,MLEC,PRKCSH,DERL2,EDEM1,EDEM3,MOGS,PDIA3,UGGT2,UGGT1,SYVN1,EDEM2,CANX
R-HSA-176412	Phosphorylation of the APC/C	0.00159014507745519	-6.44393002322994	17	13	0.00413223140495868	3146	8202	64682,51433,996,51529,10393,29882,51434,8697,7321,891,11065,983,7324	ANAPC1,ANAPC5,CDC27,ANAPC11,ANAPC10,ANAPC2,ANAPC7,CDC23,UBE2D1,CCNB1,UBE2C,CDK1,UBE2E1
R-HSA-5627117	RHO GTPases Activate ROCKs	0.00159014507745519	-6.44393002322994	17	13	0.00413223140495868	3146	8202	10398,387,4659,3984,389,5500,4660,4637,6093,4628,9475,388,3985	MYL9,RHOA,PPP1R12A,LIMK1,RHOC,PPP1CB,PPP1R12B,MYL6,ROCK1,MYH10,ROCK2,RHOB,LIMK2
R-HSA-69205	G1/S-Specific Transcription	0.00159014507745519	-6.44393002322994	17	13	0.00413223140495868	3146	8202	8318,993,5111,5422,7027,1719,6241,7298,990,983,898,7084,26271	CDC45,CDC25A,PCNA,POLA1,TFDP1,DHFR,RRM2,TYMS,CDC6,CDK1,CCNE1,TK2,FBXO5
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	0.00159640726250359	-6.43999963549937	46	28	0.00890019071837254	3146	8202	6881,6884,6877,5438,5436,5441,5440,6872,6908,2071,102157402,5433,404672,6875,5430,2962,6873,5432,4331,2957,83860,5434,2963,6882,6883,2068,2959,6878	TAF10,TAF13,TAF5,POLR2I,POLR2G,POLR2L,POLR2K,TAF1,TBP,ERCC3,AK6,POLR2D,GTF2H5,TAF4B,POLR2A,GTF2F1,TAF2,POLR2C,MNAT1,GTF2A1,TAF3,POLR2E,GTF2F2,TAF11,TAF12,ERCC2,GTF2B,TAF6
R-HSA-73776	RNA Polymerase II Promoter Escape	0.00159640726250359	-6.43999963549937	46	28	0.00890019071837254	3146	8202	6881,6884,6877,5438,5436,5441,5440,6872,6908,2071,102157402,5433,404672,6875,5430,2962,6873,5432,4331,2957,83860,5434,2963,6882,6883,2068,2959,6878	TAF10,TAF13,TAF5,POLR2I,POLR2G,POLR2L,POLR2K,TAF1,TBP,ERCC3,AK6,POLR2D,GTF2H5,TAF4B,POLR2A,GTF2F1,TAF2,POLR2C,MNAT1,GTF2A1,TAF3,POLR2E,GTF2F2,TAF11,TAF12,ERCC2,GTF2B,TAF6
R-HSA-167161	HIV Transcription Initiation	0.00159640726250359	-6.43999963549937	46	28	0.00890019071837254	3146	8202	6884,6881,6877,5438,5436,5441,6872,2071,5440,6908,102157402,5433,404672,6875,5430,2962,4331,5432,6873,2957,83860,5434,2963,2068,6882,6883,2959,6878	TAF13,TAF10,TAF5,POLR2I,POLR2G,POLR2L,TAF1,ERCC3,POLR2K,TBP,AK6,POLR2D,GTF2H5,TAF4B,POLR2A,GTF2F1,MNAT1,POLR2C,TAF2,GTF2A1,TAF3,POLR2E,GTF2F2,ERCC2,TAF11,TAF12,GTF2B,TAF6
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	0.00159640726250359	-6.43999963549937	46	28	0.00890019071837254	3146	8202	6881,6884,6877,5438,5436,5441,5440,6872,6908,2071,102157402,5433,404672,6875,5430,2962,6873,5432,4331,2957,83860,5434,2963,6882,6883,2068,2959,6878	TAF10,TAF13,TAF5,POLR2I,POLR2G,POLR2L,POLR2K,TAF1,TBP,ERCC3,AK6,POLR2D,GTF2H5,TAF4B,POLR2A,GTF2F1,TAF2,POLR2C,MNAT1,GTF2A1,TAF3,POLR2E,GTF2F2,TAF11,TAF12,ERCC2,GTF2B,TAF6
R-HSA-75953	RNA Polymerase II Transcription Initiation	0.00159640726250359	-6.43999963549937	46	28	0.00890019071837254	3146	8202	6881,6884,6877,5438,5436,5441,5440,6872,6908,2071,102157402,5433,404672,6875,5430,2962,6873,5432,4331,2957,83860,5434,2963,6882,6883,2068,2959,6878	TAF10,TAF13,TAF5,POLR2I,POLR2G,POLR2L,POLR2K,TAF1,TBP,ERCC3,AK6,POLR2D,GTF2H5,TAF4B,POLR2A,GTF2F1,TAF2,POLR2C,MNAT1,GTF2A1,TAF3,POLR2E,GTF2F2,TAF11,TAF12,ERCC2,GTF2B,TAF6
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	0.00159640726250359	-6.43999963549937	46	28	0.00890019071837254	3146	8202	6884,6881,6877,5438,5436,5441,6872,2071,5440,6908,102157402,5433,404672,6875,5430,2962,4331,5432,6873,2957,83860,5434,2963,2068,6882,6883,2959,6878	TAF13,TAF10,TAF5,POLR2I,POLR2G,POLR2L,TAF1,ERCC3,POLR2K,TBP,AK6,POLR2D,GTF2H5,TAF4B,POLR2A,GTF2F1,MNAT1,POLR2C,TAF2,GTF2A1,TAF3,POLR2E,GTF2F2,ERCC2,TAF11,TAF12,GTF2B,TAF6
R-HSA-1980145	Signaling by NOTCH2	0.00159918715524199	-6.43825980680009	32	21	0.0066751430387794	3146	8202	142678,2033,3280,54567,7311,102,51107,54492,83464,7316,57534,4192,182,6233,10046,5664,3516,9794,7314,23385,55534	MIB2,EP300,HES1,DLL4,UBA52,ADAM10,APH1A,NEURL1B,APH1B,UBC,MIB1,MDK,JAG1,RPS27A,MAMLD1,PSEN2,RBPJ,MAML1,UBB,NCSTN,MAML3
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	0.00162479342157606	-6.42237459646549	44	27	0.00858232676414495	3146	8202	51497,9150,5438,5436,6923,5441,2071,5440,7936,5433,6921,404672,6829,5430,2962,4331,5432,8178,905,6827,5434,2963,22916,6917,2068,25920,6749	NELFCD,CTDP1,POLR2I,POLR2G,TCEB2,POLR2L,ERCC3,POLR2K,NELFE,POLR2D,TCEB1,GTF2H5,SUPT5H,POLR2A,GTF2F1,MNAT1,POLR2C,ELL,CCNT2,SUPT4H1,POLR2E,GTF2F2,NCBP2,TCEA1,ERCC2,NELFB,SSRP1
R-HSA-75955	RNA Polymerase II Transcription Elongation	0.00162479342157606	-6.42237459646549	44	27	0.00858232676414495	3146	8202	51497,9150,5438,5436,5441,6923,7936,5440,2071,5433,6921,404672,6829,5430,2962,5432,4331,8178,905,6827,5434,2963,22916,6917,2068,25920,6749	NELFCD,CTDP1,POLR2I,POLR2G,POLR2L,TCEB2,NELFE,POLR2K,ERCC3,POLR2D,TCEB1,GTF2H5,SUPT5H,POLR2A,GTF2F1,POLR2C,MNAT1,ELL,CCNT2,SUPT4H1,POLR2E,GTF2F2,NCBP2,TCEA1,ERCC2,NELFB,SSRP1
R-HSA-112382	Formation of RNA Pol II elongation complex	0.00162479342157606	-6.42237459646549	44	27	0.00858232676414495	3146	8202	51497,9150,5438,5436,5441,6923,7936,5440,2071,5433,6921,404672,6829,5430,2962,5432,4331,8178,905,6827,5434,2963,22916,6917,2068,25920,6749	NELFCD,CTDP1,POLR2I,POLR2G,POLR2L,TCEB2,NELFE,POLR2K,ERCC3,POLR2D,TCEB1,GTF2H5,SUPT5H,POLR2A,GTF2F1,POLR2C,MNAT1,ELL,CCNT2,SUPT4H1,POLR2E,GTF2F2,NCBP2,TCEA1,ERCC2,NELFB,SSRP1
R-HSA-936440	Negative regulators of RIG-I/MDA5 signaling	0.00163542566207237	-6.41585216474133	34	22	0.00699300699300699	3146	8202	55593,7323,29110,7311,7128,83737,8887,9140,51191,3661,9636,7316,9246,6233,7706,7322,9474,84282,7321,7314,64135,5094	OTUD5,UBE2D3,TBK1,UBA52,TNFAIP3,ITCH,TAX1BP1,ATG12,HERC5,IRF3,ISG15,UBC,UBE2L6,RPS27A,TRIM25,UBE2D2,ATG5,RNF135,UBE2D1,UBB,IFIH1,PCBP2
R-HSA-5696394	DNA Damage Recognition in GG-NER	0.0016638737177234	-6.3986068302542	38	24	0.00762873490146217	3146	8202	1643,7311,10445,9318,7508,9978,54617,8450,7316,5886,50813,51138,6233,8533,5887,60,79913,64708,125476,10980,7528,7314,83444,1642	DDB2,UBA52,MCRS1,COPS2,XPC,RBX1,INO80,CUL4B,UBC,RAD23A,COPS7A,COPS4,RPS27A,COPS3,RAD23B,ACTB,ACTR5,COPS7B,INO80C,COPS6,YY1,UBB,INO80B,DDB1
R-HSA-69236	G1 Phase	0.0016638737177234	-6.3986068302542	38	24	0.00762873490146217	3146	8202	1030,7311,1875,1871,6502,5520,8454,1026,5519,7316,4331,1031,6233,1874,896,7027,1027,1163,7029,7314,1870,1032,1021,1029	CDKN2B,UBA52,E2F5,E2F3,SKP2,PPP2R2A,CUL1,CDKN1A,PPP2R1B,UBC,MNAT1,CDKN2C,RPS27A,E2F4,CCND3,TFDP1,CDKN1B,CKS1B,TFDP2,UBB,E2F2,CDKN2D,CDK6,CDKN2A
R-HSA-111465	Apoptotic cleavage of cellular proteins	0.0016638737177234	-6.3986068302542	38	24	0.00762873490146217	3146	8202	836,118,63967,839,28988,324,7082,22985,5747,5339,1832,10134,329,4000,2934,840,2339,1499,51765,1829,6093,841,4137,6709	CASP3,ADD1,CLSPN,CASP6,DBNL,APC,TJP1,ACIN1,PTK2,PLEC,DSP,BCAP31,BIRC2,LMNA,GSN,CASP7,FNTA,CTNNB1,STK26,DSG2,ROCK1,CASP8,MAPT,SPTAN1
R-HSA-69231	Cyclin D associated events in G1	0.0016638737177234	-6.3986068302542	38	24	0.00762873490146217	3146	8202	1030,7311,1875,1871,6502,5520,8454,1026,5519,7316,4331,1031,6233,1874,896,7027,1027,1163,7029,7314,1870,1032,1021,1029	CDKN2B,UBA52,E2F5,E2F3,SKP2,PPP2R2A,CUL1,CDKN1A,PPP2R1B,UBC,MNAT1,CDKN2C,RPS27A,E2F4,CCND3,TFDP1,CDKN1B,CKS1B,TFDP2,UBB,E2F2,CDKN2D,CDK6,CDKN2A
R-HSA-193704	p75 NTR receptor-mediated signalling	0.00166873644791498	-6.39568855694833	82	45	0.0143038779402416	3146	8202	5599,836,50650,7410,5879,7204,57142,7531,83464,84894,57449,8878,9138,3551,5664,5584,835,9181,10018,9828,7314,5970,6453,6655,6868,387,7311,51107,6654,10276,8841,84033,23365,11214,7316,23421,27018,6233,396,3065,23229,23385,64857,3066,2245	MAPK8,CASP3,ARHGEF3,VAV2,RAC1,TRIO,RTN4,YWHAE,APH1B,LINGO1,PLEKHG5,SQSTM1,ARHGEF1,IKBKB,PSEN2,PRKCI,CASP2,ARHGEF2,BCL2L11,ARHGEF17,UBB,RELA,ITSN1,SOS2,ADAM17,RHOA,UBA52,APH1A,SOS1,NET1,HDAC3,OBSCN,ARHGEF12,AKAP13,UBC,ITGB3BP,NGFRAP1,RPS27A,ARHGDIA,HDAC1,ARHGEF9,NCSTN,PLEKHG2,HDAC2,FGD1
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	0.00167826951364638	-6.38999206783546	115	60	0.0190718372536554	3146	8202	2033,2180,6256,51003,25942,29079,1387,4899,81857,3157,23054,112950,84246,9441,4520,1490,6721,7004,9968,4199,9443,55588,5469,4801,10498,6837,8463,2222,3156,6667,7296,23309,80205,1024,5468,7003,8841,5465,2274,6604,10413,10025,9969,57761,8202,23097,51,51586,406,25937,4802,211,9440,6907,9611,9282,9575,2101,10891,9412	EP300,ACSL1,RXRA,MED31,SIN3A,MED4,CREBBP,NRF1,MED25,HMGCS1,NCOA6,MED8,MED10,MED26,MTF1,CTGF,SREBF2,TEAD4,MED12,ME1,MED7,MED29,MED1,NFYB,CARM1,MED22,TEAD2,FDFT1,HMGCR,SP1,TXNRD1,SIN3B,CHD9,CDK8,PPARG,TEAD1,HDAC3,PPARA,FHL2,SMARCD3,YAP1,MED16,MED13,TRIB3,NCOA3,CDK19,ACOX1,MED15,ARNTL,WWTR1,NFYC,ALAS1,MED17,TBL1X,NCOR1,MED14,CLOCK,ESRRA,PPARGC1A,MED21
R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.00174539665177469	-6.35077344155093	312	145	0.0460902733630006	3146	8202	8936,4763,5786,5720,3709,5519,5906,5696,1499,63916,5688,5296,5701,10818,5567,64223,7311,4690,9978,208,283455,857,7422,5335,1398,5719,1535,6233,4296,2185,4254,5527,5690,1500,6093,5705,409,5700,5528,5689,5693,3728,1495,7410,5245,8649,5713,808,10256,5715,1847,5062,9475,5686,10152,23191,7867,5702,5908,8437,5605,5685,5691,10458,5921,5704,3708,2069,10163,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5879,5604,2064,5566,5687,6464,55845,6711,23198,10213,253260,10768,7414,207,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,558,5709,80824,5590,5536,9861,5594,5711,1844,673,5716,8877,79109,9491,5708,117145,3717,5717,2065,3320,7314,6709,1843,5694,5170,387,5692,6654,5295,5747,5710,9564,7316,5595,2885,57761,84078,152559,3685,84292,3265	WASF1,NF1,PTPRA,PSME1,ITPR2,PPP2R1B,RAP1A,PSMB8,CTNNB1,ELMO2,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,NCK1,RBX1,AKT2,KSR2,CAV1,VEGFA,PLCG1,CRK,PSMD13,CYBA,RPS27A,MAP3K11,PTK2B,KITLG,PPP2R5C,PSMB2,CTNND1,ROCK1,PSMC5,ARRB2,PSMC1,PPP2R5D,PSMB1,PSMB5,JUP,CTNNA1,VAV2,PHB,LAMTOR3,PSMD7,CALM3,CNKSR1,PSMD9,DUSP5,PAK2,ROCK2,PSMA5,ABI2,CYFIP1,MAPKAPK3,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,BAIAP2,RASA1,PSMC4,ITPR1,EREG,WASF2,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,RAC1,MAP2K1,ERBB2,PRKACA,PSMA6,SHC1,BRK1,SPTBN1,PSME4,PSMD14,RICTOR,AHCYL1,VCL,AKT1,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,AXL,PSMD3,DUSP16,PRKCZ,PPP5C,PSMD6,MAPK1,PSMD5,DUSP2,BRAF,PSMD10,SPHK1,MAPKAP1,PSMF1,PSMD2,THEM4,JAK2,PSMD11,ERBB3,HSP90AA1,UBB,SPTAN1,DUSP1,PSMB6,PDPK1,RHOA,PSMB4,SOS1,PIK3R1,PTK2,PSMD4,BCAR1,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,ITGAV,WDR83,HRAS
R-HSA-380259	Loss of Nlp from mitotic centrosomes	0.0018469639096203	-6.29421211795578	63	36	0.0114431023521933	3146	8202	11258,1781,10142,11116,5116,80321,10383,5048,8655,7531,5566,55142,9793,9702,80184,55835,84131,10733,4751,3320,80254,1454,55755,121441,79959,22994,983,7532,5108,4957,10806,8481,54820,55125,7840,203068	DCTN3,DYNC1I2,AKAP9,FGFR1OP,PCNT,CEP70,TUBB4B,PAFAH1B1,DYNLL1,YWHAE,PRKACA,HAUS2,CKAP5,CEP57,CEP290,CENPJ,CEP78,PLK4,NEK2,HSP90AA1,CEP63,CSNK1E,CDK5RAP2,NEDD1,CEP76,CEP131,CDK1,YWHAG,PCM1,ODF2,SDCCAG8,OFD1,NDE1,CEP192,ALMS1,TUBB
R-HSA-380284	Loss of proteins required for interphase microtubule organizationfrom the centrosome	0.0018469639096203	-6.29421211795578	63	36	0.0114431023521933	3146	8202	11258,1781,10142,11116,5116,80321,10383,5048,8655,7531,5566,55142,9793,9702,80184,55835,84131,10733,4751,3320,80254,1454,55755,121441,79959,22994,983,7532,5108,4957,10806,8481,54820,55125,7840,203068	DCTN3,DYNC1I2,AKAP9,FGFR1OP,PCNT,CEP70,TUBB4B,PAFAH1B1,DYNLL1,YWHAE,PRKACA,HAUS2,CKAP5,CEP57,CEP290,CENPJ,CEP78,PLK4,NEK2,HSP90AA1,CEP63,CSNK1E,CDK5RAP2,NEDD1,CEP76,CEP131,CDK1,YWHAG,PCM1,ODF2,SDCCAG8,OFD1,NDE1,CEP192,ALMS1,TUBB
R-HSA-69618	Mitotic Spindle Checkpoint	0.00189921216973543	-6.26631612630746	19	14	0.00445009535918627	3146	8202	64682,51433,996,991,4085,51529,10393,8379,29882,51434,8697,7321,11065,7324	ANAPC1,ANAPC5,CDC27,CDC20,MAD2L1,ANAPC11,ANAPC10,MAD1L1,ANAPC2,ANAPC7,CDC23,UBE2D1,UBE2C,UBE2E1
R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	0.00192125152794335	-6.25477846782572	12	10	0.00317863954227591	3146	8202	836,2934,840,118,839,28988,5339,841,4137,6709	CASP3,GSN,CASP7,ADD1,CASP6,DBNL,PLEC,CASP8,MAPT,SPTAN1
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.00194020654506196	-6.24496084504728	89	48	0.0152574698029243	3146	8202	5599,23291,3146,257397,5604,1660,30849,8454,4205,1147,9252,8411,5519,5606,466,6196,3551,5601,51135,4791,7314,5598,1386,5970,4214,7311,5609,7867,51295,7335,1846,7316,5595,64145,10392,23118,6233,1845,5608,4793,10454,79155,5594,5528,170506,6416,7334,6197	MAPK8,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,PIK3R4,CUL1,MEF2A,CHUK,RPS6KA5,EEA1,PPP2R1B,MAP2K3,ATF1,RPS6KA2,IKBKB,MAPK9,IRAK4,NFKB2,UBB,MAPK7,ATF2,RELA,MAP3K1,UBA52,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,DUSP4,UBC,MAPK3,RBSN,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,DHX36,MAP2K4,UBE2N,RPS6KA3
R-HSA-194138	Signaling by VEGF	0.00199912380521922	-6.21504629180528	320	148	0.0470438652256834	3146	8202	8936,4763,5786,5720,3709,5519,5906,5696,1499,63916,5688,5296,5701,10818,5567,64223,7311,4690,9978,208,283455,857,7422,5335,1398,5719,1535,6233,4296,2185,4254,5527,5690,1500,6093,8829,5705,409,5700,5528,5689,5693,3728,1495,7410,5245,8649,5713,808,10256,5715,1847,5062,9475,5686,7423,10152,23191,7867,5702,5908,8437,5605,5685,5691,10458,5921,5704,3708,2069,10163,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5879,5604,2064,5566,5687,6464,55845,6711,23198,10213,253260,10768,7414,207,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,558,5709,80824,5590,5536,9861,5594,5711,1844,673,5716,8877,79109,9491,8828,5708,117145,3717,5717,2065,3320,7314,6709,1843,5694,5170,387,5692,6654,5295,5747,5710,9564,7316,5595,2885,57761,84078,152559,3685,84292,3265	WASF1,NF1,PTPRA,PSME1,ITPR2,PPP2R1B,RAP1A,PSMB8,CTNNB1,ELMO2,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,NCK1,RBX1,AKT2,KSR2,CAV1,VEGFA,PLCG1,CRK,PSMD13,CYBA,RPS27A,MAP3K11,PTK2B,KITLG,PPP2R5C,PSMB2,CTNND1,ROCK1,NRP1,PSMC5,ARRB2,PSMC1,PPP2R5D,PSMB1,PSMB5,JUP,CTNNA1,VAV2,PHB,LAMTOR3,PSMD7,CALM3,CNKSR1,PSMD9,DUSP5,PAK2,ROCK2,PSMA5,VEGFB,ABI2,CYFIP1,MAPKAPK3,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,BAIAP2,RASA1,PSMC4,ITPR1,EREG,WASF2,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,RAC1,MAP2K1,ERBB2,PRKACA,PSMA6,SHC1,BRK1,SPTBN1,PSME4,PSMD14,RICTOR,AHCYL1,VCL,AKT1,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,AXL,PSMD3,DUSP16,PRKCZ,PPP5C,PSMD6,MAPK1,PSMD5,DUSP2,BRAF,PSMD10,SPHK1,MAPKAP1,PSMF1,NRP2,PSMD2,THEM4,JAK2,PSMD11,ERBB3,HSP90AA1,UBB,SPTAN1,DUSP1,PSMB6,PDPK1,RHOA,PSMB4,SOS1,PIK3R1,PTK2,PSMD4,BCAR1,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,ITGAV,WDR83,HRAS
R-HSA-73864	RNA Polymerase I Transcription	0.00202087240126343	-6.20422597898955	109	57	0.0181182453909727	3146	8202	57504,3015,5440,8367,6908,2071,8358,8350,404672,7270,8360,8365,121504,54815,54700,9014,8366,10849,8932,8364,653604,1108,8345,2068,84172,30834,64425,8331,57459,8968,8352,5441,2648,5931,79101,9219,8368,8357,53615,221830,5595,8294,7343,4331,3012,8334,2074,1107,8351,5434,3014,3065,9533,3020,8338,3066,8354	MTA3,H2AFZ,POLR2K,HIST1H4E,TBP,ERCC3,HIST1H3B,HIST1H3A,GTF2H5,TTF1,HIST1H4D,HIST1H4H,HIST4H4,GATAD2A,RRN3,TAF1B,HIST1H4B,CD3EAP,MBD2,HIST1H4C,HIST2H3D,CHD4,HIST1H2BH,ERCC2,POLR1B,ZNRD1,POLR1E,HIST1H2AJ,GATAD2B,HIST1H3F,HIST1H3C,POLR2L,KAT2A,RBBP7,TAF1D,MTA2,HIST1H4L,HIST1H3H,MBD3,TWISTNB,MAPK3,HIST1H4I,UBTF,MNAT1,HIST1H2AE,HIST1H2AC,ERCC6,CHD3,HIST1H3D,POLR2E,H2AFX,HDAC1,POLR1C,H3F3A,HIST2H2AC,HDAC2,HIST1H3I
R-HSA-2979096	NOTCH2 Activation and Transmission of Signal to the Nucleus	0.00215961033442314	-6.13782747429026	21	15	0.00476795931341386	3146	8202	4192,142678,54567,182,7311,102,51107,6233,5664,54492,7314,83464,23385,7316,57534	MDK,MIB2,DLL4,JAG1,UBA52,ADAM10,APH1A,RPS27A,PSEN2,NEURL1B,UBB,APH1B,NCSTN,UBC,MIB1
R-HSA-390918	Peroxisomal lipid metabolism	0.00215961033442314	-6.13782747429026	21	15	0.00476795931341386	3146	8202	11001,1384,54677,51,8443,6342,215,3295,30,3417,84188,8310,5264,10478,10005	SLC27A2,CRAT,CROT,ACOX1,GNPAT,SCP2,ABCD1,HSD17B4,ACAA1,IDH1,FAR1,ACOX3,PHYH,SLC25A17,ACOT8
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	0.00237079239756735	-6.04453103475079	23	16	0.00508582326764145	3146	8202	5984,5983,7311,3978,3980,10714,5982,5424,7316,5111,5427,5426,6233,5981,7314,5425	RFC4,RFC3,UBA52,LIG1,LIG3,POLD3,RFC2,POLD1,UBC,PCNA,POLE2,POLE,RPS27A,RFC1,UBB,POLD2
R-HSA-191273	Cholesterol biosynthesis	0.00237079239756735	-6.04453103475079	23	16	0.00508582326764145	3146	8202	4047,3422,3157,6307,50814,2224,7108,1717,64801,9453,10654,6309,3930,10682,2222,3156	LSS,IDI1,HMGCS1,MSMO1,NSDHL,FDPS,TM7SF2,DHCR7,ARV1,GGPS1,PMVK,SC5D,LBR,EBP,FDFT1,HMGCR
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	0.00237079239756735	-6.04453103475079	23	16	0.00508582326764145	3146	8202	5984,5983,328,5558,5422,3978,10714,5982,5424,5557,5111,5427,5426,1763,5981,5425	RFC4,RFC3,APEX1,PRIM2,POLA1,LIG1,POLD3,RFC2,POLD1,PRIM1,PCNA,POLE2,POLE,DNA2,RFC1,POLD2
R-HSA-199977	ER to Golgi Anterograde Transport	0.00242289660791629	-6.02279150916166	68	38	0.0120788302606484	3146	8202	6396,7109,9871,26984,10652,9919,9117,966,1075,9632,81562,81876,10342,3998,22870,6811,10113,10802,10484,83696,23256,7039,375056,10282,1294,5861,122553,51693,22872,51128,10427,27095,63908,4253,9554,55291,8775,79090	SEC13,TRAPPC10,SEC24D,SEC22A,YKT6,SEC16A,SEC22C,CD59,CTSC,SEC24C,LMAN2L,RAB1B,TFG,LMAN1,PPP6R1,STX5,PREB,SEC24A,SEC23A,TRAPPC9,SCFD1,TGFA,MIA3,BET1,COL7A1,RAB1A,TRAPPC6B,TRAPPC2L,SEC31A,SAR1B,SEC24B,TRAPPC3,NAPB,CTAGE5,SEC22B,PPP6R3,NAPA,TRAPPC6A
R-HSA-166054	Activated TLR4 signalling	0.00248765369782294	-5.99641530277081	112	58	0.0184361093452003	3146	8202	5599,7323,23291,3146,257397,5604,1660,8454,4205,1147,3661,9252,329,5519,5606,466,6196,8651,10010,3551,5601,51135,5781,4791,841,7314,5598,7321,1386,5970,4214,29110,7311,5609,330,7867,51295,7335,1846,10333,7316,5595,10392,23118,6233,1845,5608,7322,148022,4793,10454,79155,5594,5528,6416,7334,6197,114609	MAPK8,UBE2D3,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,IRF3,RPS6KA5,BIRC2,PPP2R1B,MAP2K3,ATF1,RPS6KA2,SOCS1,TANK,IKBKB,MAPK9,IRAK4,PTPN11,NFKB2,CASP8,UBB,MAPK7,UBE2D1,ATF2,RELA,MAP3K1,TBK1,UBA52,MAP2K7,BIRC3,MAPKAPK3,ECSIT,UBE2V1,DUSP4,TLR6,UBC,MAPK3,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,UBE2D2,TICAM1,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,MAP2K4,UBE2N,RPS6KA3,TIRAP
R-HSA-1989781	PPARA activates gene expression	0.00248765369782294	-5.99641530277081	112	58	0.0184361093452003	3146	8202	2033,2180,6256,51003,29079,1387,4899,81857,3157,23054,112950,84246,9441,4520,1490,6721,7004,9968,4199,9443,55588,5469,4801,10498,6837,8463,2222,3156,6667,7296,80205,1024,5468,7003,8841,5465,2274,6604,10413,10025,9969,57761,8202,23097,51,51586,406,25937,4802,211,9440,6907,9611,9282,9575,2101,10891,9412	EP300,ACSL1,RXRA,MED31,MED4,CREBBP,NRF1,MED25,HMGCS1,NCOA6,MED8,MED10,MED26,MTF1,CTGF,SREBF2,TEAD4,MED12,ME1,MED7,MED29,MED1,NFYB,CARM1,MED22,TEAD2,FDFT1,HMGCR,SP1,TXNRD1,CHD9,CDK8,PPARG,TEAD1,HDAC3,PPARA,FHL2,SMARCD3,YAP1,MED16,MED13,TRIB3,NCOA3,CDK19,ACOX1,MED15,ARNTL,WWTR1,NFYC,ALAS1,MED17,TBL1X,NCOR1,MED14,CLOCK,ESRRA,PPARGC1A,MED21
R-HSA-2990846	SUMOylation	0.00258697611898739	-5.9572656069815	79	43	0.0136681500317864	3146	8202	51588,23511,7508,8480,79677,10055,348995,9656,641,23165,6015,129401,9883,7341,9126,6996,6672,10054,51564,84733,57122,9972,205564,79902,29843,81929,10274,10735,22955,9631,672,8021,56160,7175,5903,286053,197370,8243,9063,23636,493861,8535,1029	PIAS4,NUP188,XPC,RAE1,SMC6,SAE1,NUP43,MDC1,BLM,NUP205,RING1,NUP35,POM121,SUMO1,SMC3,TDG,SP100,UBA2,HDAC7,CBX2,NUP107,NUP153,SENP5,NUP85,SENP1,SEH1L,STAG1,STAG2,SCMH1,NUP155,BRCA1,NUP214,NDNL2,TPR,RANBP2,NSMCE2,NSMCE1,SMC1A,PIAS2,NUP62,EID3,CBX4,CDKN2A
R-HSA-71406	Pyruvate metabolism and Citric Acid (TCA) cycle	0.00259090983219872	-5.95574617839416	45	27	0.00858232676414495	3146	8202	5160,5163,8802,54704,6391,4191,3419,6256,9123,682,3418,5165,1743,8050,51660,6392,5467,50,5164,25874,23530,728294,1431,6566,8801,3420,3945	PDHA1,PDK1,SUCLG1,PDP1,SDHC,MDH2,IDH3A,RXRA,SLC16A3,BSG,IDH2,PDK3,DLST,PDHX,MPC1,SDHD,PPARD,ACO2,PDK2,MPC2,NNT,D2HGDH,CS,SLC16A1,SUCLG2,IDH3B,LDHB
R-HSA-174411	Polymerase switching on the C-strand of the telomere	0.0026201935653792	-5.94450708402239	14	11	0.0034965034965035	3146	8202	5984,5111,5983,5558,5422,5981,10714,5424,5982,5425,5557	RFC4,PCNA,RFC3,PRIM2,POLA1,RFC1,POLD3,POLD1,RFC2,POLD2,PRIM1
R-HSA-69091	Polymerase switching	0.0026201935653792	-5.94450708402239	14	11	0.0034965034965035	3146	8202	5984,5111,5983,5558,5422,5981,10714,5424,5982,5425,5557	RFC4,PCNA,RFC3,PRIM2,POLA1,RFC1,POLD3,POLD1,RFC2,POLD2,PRIM1
R-HSA-69109	Leading Strand Synthesis	0.0026201935653792	-5.94450708402239	14	11	0.0034965034965035	3146	8202	5984,5111,5983,5558,5422,5981,10714,5424,5982,5425,5557	RFC4,PCNA,RFC3,PRIM2,POLA1,RFC1,POLD3,POLD1,RFC2,POLD2,PRIM1
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	0.0026582170681411	-5.93009965605826	43	26	0.00826446280991736	3146	8202	51497,9150,5438,5436,6923,5441,2071,5440,7936,5433,6921,404672,6829,5430,2962,4331,5432,8178,6827,5434,2963,22916,6917,2068,25920,6749	NELFCD,CTDP1,POLR2I,POLR2G,TCEB2,POLR2L,ERCC3,POLR2K,NELFE,POLR2D,TCEB1,GTF2H5,SUPT5H,POLR2A,GTF2F1,MNAT1,POLR2C,ELL,SUPT4H1,POLR2E,GTF2F2,NCBP2,TCEA1,ERCC2,NELFB,SSRP1
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	0.0026582170681411	-5.93009965605826	43	26	0.00826446280991736	3146	8202	51497,9150,5438,5436,6923,5441,2071,5440,7936,5433,6921,404672,6829,5430,2962,4331,5432,8178,6827,5434,2963,22916,6917,2068,25920,6749	NELFCD,CTDP1,POLR2I,POLR2G,TCEB2,POLR2L,ERCC3,POLR2K,NELFE,POLR2D,TCEB1,GTF2H5,SUPT5H,POLR2A,GTF2F1,MNAT1,POLR2C,ELL,SUPT4H1,POLR2E,GTF2F2,NCBP2,TCEA1,ERCC2,NELFB,SSRP1
R-HSA-167169	HIV Transcription Elongation	0.0026582170681411	-5.93009965605826	43	26	0.00826446280991736	3146	8202	51497,9150,5438,5436,6923,5441,2071,5440,7936,5433,6921,404672,6829,5430,2962,4331,5432,8178,6827,5434,2963,22916,6917,2068,25920,6749	NELFCD,CTDP1,POLR2I,POLR2G,TCEB2,POLR2L,ERCC3,POLR2K,NELFE,POLR2D,TCEB1,GTF2H5,SUPT5H,POLR2A,GTF2F1,MNAT1,POLR2C,ELL,SUPT4H1,POLR2E,GTF2F2,NCBP2,TCEA1,ERCC2,NELFB,SSRP1
R-HSA-168325	Viral Messenger RNA Synthesis	0.00271717095675113	-5.90816402937232	41	25	0.00794659885568976	3146	8202	5438,23511,5436,5441,5440,8480,5433,9631,348995,8021,23165,5430,129401,9883,2962,5432,7175,5903,57122,5434,2963,23636,9972,79902,81929	POLR2I,NUP188,POLR2G,POLR2L,POLR2K,RAE1,POLR2D,NUP155,NUP43,NUP214,NUP205,POLR2A,NUP35,POM121,GTF2F1,POLR2C,TPR,RANBP2,NUP107,POLR2E,GTF2F2,NUP62,NUP153,NUP85,SEH1L
R-HSA-180786	Extension of Telomeres	0.00274240505943281	-5.89891998467016	29	19	0.00603941513032422	3146	8202	5984,5983,328,5558,5422,3978,1736,10714,5982,5424,5557,5111,5427,5426,1763,5981,10856,55135,5425	RFC4,RFC3,APEX1,PRIM2,POLA1,LIG1,DKC1,POLD3,RFC2,POLD1,PRIM1,PCNA,POLE2,POLE,DNA2,RFC1,RUVBL2,WRAP53,POLD2
R-HSA-165159	mTOR signalling	0.00276552537755207	-5.89052465209286	39	24	0.00762873490146217	3146	8202	7249,207,2475,208,5565,92335,5562,8649,64121,5571,6009,10542,57521,1981,51422,1978,389541,6194,10325,5494,6198,1977,64223,58528	TSC2,AKT1,MTOR,AKT2,PRKAB2,STRADA,PRKAA1,LAMTOR3,RRAGC,PRKAG1,RHEB,LAMTOR5,RPTOR,EIF4G1,PRKAG2,EIF4EBP1,LAMTOR4,RPS6,RRAGB,PPM1A,RPS6KB1,EIF4E,MLST8,RRAGD
R-HSA-176187	Activation of ATR in response to replication stress	0.00280067084481828	-5.87789630306237	37	23	0.00731087094723458	3146	8202	5883,993,5984,4999,4175,5983,55388,5810,63967,10926,1111,990,5982,995,8318,5000,8317,5001,84515,84126,23595,23594,4172	RAD9A,CDC25A,RFC4,ORC2,MCM6,RFC3,MCM10,RAD1,CLSPN,DBF4,CHEK1,CDC6,RFC2,CDC25C,CDC45,ORC4,CDC7,ORC5,MCM8,ATRIP,ORC3,ORC6,MCM3
R-HSA-450294	MAP kinase activation in TLR cascade	0.00295646671007678	-5.82376040267655	60	34	0.0108073744437381	3146	8202	5599,23291,7311,5609,257397,7867,5604,8454,4205,1147,1846,9252,5519,7316,5606,5595,466,6196,10392,23118,6233,1845,5608,3551,5601,7314,5598,10454,1386,79155,5594,5528,6416,6197	MAPK8,FBXW11,UBA52,MAP2K7,TAB3,MAPKAPK3,MAP2K1,CUL1,MEF2A,CHUK,DUSP4,RPS6KA5,PPP2R1B,UBC,MAP2K3,MAPK3,ATF1,RPS6KA2,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,IKBKB,MAPK9,UBB,MAPK7,TAB1,ATF2,TNIP2,MAPK1,PPP2R5D,MAP2K4,RPS6KA3
R-HSA-3371556	Cellular response to heat stress	0.00296525756330465	-5.8207913824116	86	46	0.0146217418944692	3146	8202	2033,10808,23511,2475,8480,3297,3337,348995,7531,9532,10013,1915,3303,9883,23165,129401,51182,57521,1387,10049,57122,9972,6782,3320,10728,79902,81929,64223,9529,23411,3326,57805,9631,8021,3304,5595,3305,7175,5903,817,3308,2932,23636,22824,5594,573	EP300,HSPH1,NUP188,MTOR,RAE1,HSF1,DNAJB1,NUP43,YWHAE,BAG2,HDAC6,EEF1A1,HSPA1A,POM121,NUP205,NUP35,HSPA14,RPTOR,CREBBP,DNAJB6,NUP107,NUP153,HSPA13,HSP90AA1,PTGES3,NUP85,SEH1L,MLST8,BAG5,SIRT1,HSP90AB1,CCAR2,NUP155,NUP214,HSPA1B,MAPK3,HSPA1L,TPR,RANBP2,CAMK2D,HSPA4,GSK3B,NUP62,HSPA4L,MAPK1,BAG1
R-HSA-390247	Beta-oxidation of very long chain fatty acids	0.00317509145250877	-5.75241884311254	6	6	0.00190718372536554	3146	8202	215,3295,30,1384,51,10005	ABCD1,HSD17B4,ACAA1,CRAT,ACOX1,ACOT8
R-HSA-5674499	Negative feedback regulation of MAPK pathway	0.00317509145250877	-5.75241884311254	6	6	0.00190718372536554	3146	8202	673,5594,5894,5605,5595,5604	BRAF,MAPK1,RAF1,MAP2K2,MAPK3,MAP2K1
R-HSA-427413	NoRC negatively regulates rRNA expression	0.00319854435217338	-5.74505946261609	104	54	0.0171646535282899	3146	8202	3015,5440,8367,6908,2071,8358,8350,404672,25942,7270,8360,8365,121504,79595,9014,8366,10849,8932,8364,653604,8345,2068,84172,30834,64425,8331,8819,23309,8968,8352,5441,11176,79101,51742,8368,8357,29115,221830,8294,7343,4331,3012,8334,8351,5434,3014,3065,10284,9533,8467,3020,8338,3066,8354	H2AFZ,POLR2K,HIST1H4E,TBP,ERCC3,HIST1H3B,HIST1H3A,GTF2H5,SIN3A,TTF1,HIST1H4D,HIST1H4H,HIST4H4,SAP130,TAF1B,HIST1H4B,CD3EAP,MBD2,HIST1H4C,HIST2H3D,HIST1H2BH,ERCC2,POLR1B,ZNRD1,POLR1E,HIST1H2AJ,SAP30,SIN3B,HIST1H3F,HIST1H3C,POLR2L,BAZ2A,TAF1D,ARID4B,HIST1H4L,HIST1H3H,SAP30BP,TWISTNB,HIST1H4I,UBTF,MNAT1,HIST1H2AE,HIST1H2AC,HIST1H3D,POLR2E,H2AFX,HDAC1,SAP18,POLR1C,SMARCA5,H3F3A,HIST2H2AC,HDAC2,HIST1H3I
R-HSA-110312	Translesion synthesis by REV1	0.0032224448548446	-5.73761493583588	16	12	0.00381436745073109	3146	8202	5984,5980,5111,5983,7311,6233,5981,7314,5982,51455,10459,7316	RFC4,REV3L,PCNA,RFC3,UBA52,RPS27A,RFC1,UBB,RFC2,REV1,MAD2L2,UBC
R-HSA-156711	Polo-like kinase mediated events	0.0032224448548446	-5.73761493583588	16	12	0.00381436745073109	3146	8202	132660,286826,2033,993,7465,4605,9088,891,9133,995,91750,55957	LIN54,LIN9,EP300,CDC25A,WEE1,MYBL2,PKMYT1,CCNB1,CCNB2,CDC25C,LIN52,LIN37
R-HSA-975871	MyD88 cascade initiated on plasma membrane	0.0033407368657617	-5.70156387783468	82	44	0.013986013986014	3146	8202	5599,23291,3146,257397,5604,1660,8454,4205,1147,9252,5519,5606,466,6196,3551,5601,51135,4791,7314,5598,1386,5970,4214,7311,5609,7867,51295,7335,1846,7316,5595,10392,23118,6233,1845,5608,4793,10454,79155,5594,5528,6416,7334,6197	MAPK8,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,RPS6KA5,PPP2R1B,MAP2K3,ATF1,RPS6KA2,IKBKB,MAPK9,IRAK4,NFKB2,UBB,MAPK7,ATF2,RELA,MAP3K1,UBA52,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,DUSP4,UBC,MAPK3,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,MAP2K4,UBE2N,RPS6KA3
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	0.0033407368657617	-5.70156387783468	82	44	0.013986013986014	3146	8202	5599,23291,3146,257397,5604,1660,8454,4205,1147,9252,5519,5606,466,6196,3551,5601,51135,4791,7314,5598,1386,5970,4214,7311,5609,7867,51295,7335,1846,7316,5595,10392,23118,6233,1845,5608,4793,10454,79155,5594,5528,6416,7334,6197	MAPK8,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,RPS6KA5,PPP2R1B,MAP2K3,ATF1,RPS6KA2,IKBKB,MAPK9,IRAK4,NFKB2,UBB,MAPK7,ATF2,RELA,MAP3K1,UBA52,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,DUSP4,UBC,MAPK3,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,MAP2K4,UBE2N,RPS6KA3
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	0.0033407368657617	-5.70156387783468	82	44	0.013986013986014	3146	8202	5599,23291,3146,257397,5604,1660,8454,4205,1147,9252,5519,5606,466,6196,3551,5601,51135,4791,7314,5598,1386,5970,4214,7311,5609,7867,51295,7335,1846,7316,5595,10392,23118,6233,1845,5608,4793,10454,79155,5594,5528,6416,7334,6197	MAPK8,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,RPS6KA5,PPP2R1B,MAP2K3,ATF1,RPS6KA2,IKBKB,MAPK9,IRAK4,NFKB2,UBB,MAPK7,ATF2,RELA,MAP3K1,UBA52,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,DUSP4,UBC,MAPK3,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,MAP2K4,UBE2N,RPS6KA3
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	0.00339700125761159	-5.68486221959134	54	31	0.00985378258105531	3146	8202	9295,51362,23511,65109,8480,10250,10921,10482,7884,9631,348995,6430,53981,8021,9883,23165,129401,7175,5903,6427,29894,7307,6429,57122,23636,9972,22916,6428,1977,79902,81929	SRSF11,CDC40,NUP188,UPF3B,RAE1,SRRM1,RNPS1,NXF1,SLBP,NUP155,NUP43,SRSF5,CPSF2,NUP214,POM121,NUP205,NUP35,TPR,RANBP2,SRSF2,CPSF1,U2AF1,SRSF4,NUP107,NUP62,NUP153,NCBP2,SRSF3,EIF4E,NUP85,SEH1L
R-HSA-187037	NGF signalling via TRKA from the plasma membrane	0.0035243649606246	-5.64805501196171	355	161	0.0511760966306421	3146	8202	7249,4763,5786,5720,1026,3709,5519,5906,5696,6196,5688,5296,5701,1785,163,10818,5567,64223,7311,9978,208,842,283455,5898,5335,1398,5719,6233,4296,4254,2932,5527,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,5900,814,808,4205,10256,5715,1847,5581,5598,5686,7867,5702,5908,8437,6016,5605,5685,5691,5921,5704,57498,1845,160,3708,2069,6197,192669,200734,685,10142,161742,5607,26052,9462,5683,2475,5894,8826,5037,5604,2064,1147,5566,1399,4193,5687,6464,5899,6711,115,23198,10213,1027,8503,253260,10768,7414,10126,207,2931,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,5709,80824,5536,9861,4343,5594,1175,5711,1844,23112,1173,673,79109,5716,9252,2309,9491,466,5708,117145,5781,3717,5717,2065,7314,6774,6199,6709,1843,5694,5170,387,5692,4303,6654,3164,5295,5747,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,NF1,PTPRA,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,RPS6KA2,PSMA7,PIK3R2,PSMC2,DNM2,AP2B1,FRS2,PRKACB,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,RALA,PLCG1,CRK,PSMD13,RPS27A,MAP3K11,KITLG,GSK3B,PPP2R5C,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,RALGDS,CAMK4,CALM3,MEF2A,CNKSR1,PSMD9,DUSP5,PRKCE,MAPK7,PSMA5,MAPKAPK3,PSMC3,RAP1B,RASAL1,RIT1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,KIDINS220,DUSP3,AP2A1,ITPR1,EREG,RPS6KA3,AGO3,SPRED2,BTC,AKAP9,SPRED1,MAP2K5,DNM3,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,CRKL,MDM2,PSMA6,SHC1,RALB,SPTBN1,ADCY9,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,AHCYL1,VCL,DNAL4,AKT1,GSK3A,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,PPP5C,PSMD6,MOV10,MAPK1,AP2S1,PSMD5,DUSP2,TNRC6B,AP2M1,BRAF,MAPKAP1,PSMD10,RPS6KA5,FOXO3,PSMF1,ATF1,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,STAT3,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,RHOA,PSMB4,FOXO4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	0.00371514611693544	-5.59533726997473	18	13	0.00413223140495868	3146	8202	64682,51433,996,991,4085,51529,10393,29882,51434,8697,7321,11065,7324	ANAPC1,ANAPC5,CDC27,CDC20,MAD2L1,ANAPC11,ANAPC10,ANAPC2,ANAPC7,CDC23,UBE2D1,UBE2C,UBE2E1
R-HSA-141405	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	0.00371514611693544	-5.59533726997473	18	13	0.00413223140495868	3146	8202	64682,51433,996,991,4085,51529,10393,29882,51434,8697,7321,11065,7324	ANAPC1,ANAPC5,CDC27,CDC20,MAD2L1,ANAPC11,ANAPC10,ANAPC2,ANAPC7,CDC23,UBE2D1,UBE2C,UBE2E1
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.00376131962319861	-5.58298541953701	78	42	0.0133502860775588	3146	8202	2033,6517,6256,51003,1050,29079,1387,81857,23054,112950,84246,9441,6721,896,9968,9443,5970,5469,55588,1052,6837,10498,80205,7480,1024,5468,8841,5465,6604,10025,9969,8202,23097,9314,51586,9440,9611,9282,6907,10891,7026,9412	EP300,SLC2A4,RXRA,MED31,CEBPA,MED4,CREBBP,MED25,NCOA6,MED8,MED10,MED26,SREBF2,CCND3,MED12,MED7,RELA,MED1,MED29,CEBPD,MED22,CARM1,CHD9,WNT10B,CDK8,PPARG,HDAC3,PPARA,SMARCD3,MED16,MED13,NCOA3,CDK19,KLF4,MED15,MED17,NCOR1,MED14,TBL1X,PPARGC1A,NR2F2,MED21
R-HSA-73887	Death Receptor Signalling	0.00385365636796391	-5.55873287540318	48	28	0.00890019071837254	3146	8202	6868,7375,10616,7311,7128,330,257397,7186,81858,8887,8743,1147,10399,8439,27005,329,7316,7185,6233,23118,56957,55072,8567,3551,841,7314,10454,90268	ADAM17,USP4,RBCK1,UBA52,TNFAIP3,BIRC3,TAB3,TRAF2,SHARPIN,TAX1BP1,TNFSF10,CHUK,GNB2L1,NSMAF,USP21,BIRC2,UBC,TRAF1,RPS27A,TAB2,OTUD7B,RNF31,MADD,IKBKB,CASP8,UBB,TAB1,OTULIN
R-HSA-112399	IRS-mediated signalling	0.00403809837638471	-5.51198139673726	277	128	0.0406865861411316	3146	8202	161742,10142,685,200734,7249,9462,2475,4763,5683,5565,5786,8826,92335,5894,5037,5604,64121,2064,5720,5519,57521,5906,5696,5687,6464,5688,6711,5296,5701,6194,10213,23198,5494,7414,1977,10818,64223,7311,207,9978,208,5695,8452,1742,5571,283455,1846,2260,6009,8660,5529,1981,817,2534,5719,6233,5706,1978,80824,5709,4296,10325,4254,5527,5690,6198,5705,5536,9861,409,5594,5700,2549,5528,5711,58528,1844,5689,5693,673,5562,5245,30849,8649,5713,808,5716,10256,5715,9491,1847,10542,5708,117145,5781,3717,5717,2065,7314,5686,5694,1843,6709,5170,5692,6654,5295,5702,5908,8437,5747,5710,5605,5685,5691,7316,5921,5595,5704,2885,57761,51422,389541,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,TSC2,RASAL2,MTOR,NF1,PSMA2,PRKAB2,PTPRA,IQGAP1,STRADA,RAF1,PEBP1,MAP2K1,RRAGC,ERBB2,PSME1,PPP2R1B,RPTOR,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PIK3R2,PSMC2,RPS6,PSMD14,PSME4,PPM1A,VCL,EIF4E,FRS2,MLST8,UBA52,AKT1,RBX1,AKT2,PSMB7,CUL3,DLG4,PRKAG1,KSR2,DUSP4,FGFR1,RHEB,IRS2,PPP2R5E,EIF4G1,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,EIF4EBP1,DUSP16,PSMD3,MAP3K11,RRAGB,KITLG,PPP2R5C,PSMB2,RPS6KB1,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,GAB1,PPP2R5D,PSMD5,RRAGD,DUSP2,PSMB1,PSMB5,BRAF,PRKAA1,PHB,PIK3R4,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,PSMF1,DUSP5,LAMTOR5,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,PSMA5,PSMB6,DUSP1,SPTAN1,PDPK1,PSMB4,SOS1,PIK3R1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,TRIB3,PRKAG2,LAMTOR4,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	0.00411346519871791	-5.49348949165171	96	50	0.0158931977113795	3146	8202	23291,5689,5693,5683,7186,9039,5713,5716,8454,1147,5720,5715,329,9491,5708,5687,5696,5688,5701,23198,10213,970,51330,5717,9020,4791,7314,5686,5694,7311,5692,330,115650,5702,5695,958,5710,5685,5691,7316,5704,5719,6233,5706,5709,5690,5705,9861,5700,5711	FBXW11,PSMB1,PSMB5,PSMA2,TRAF2,UBA3,PSMD7,PSMD10,CUL1,CHUK,PSME1,PSMD9,BIRC2,PSMF1,PSMD2,PSMA6,PSMB8,PSMA7,PSMC2,PSME4,PSMD14,CD70,TNFRSF12A,PSMD11,MAP3K14,NFKB2,UBB,PSMA5,PSMB6,UBA52,PSMB4,BIRC3,TNFRSF13C,PSMC3,PSMB7,CD40,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PSMD13,RPS27A,PSMC6,PSMD3,PSMB2,PSMC5,PSMD6,PSMC1,PSMD5
R-HSA-68689	CDC6 association with the ORC:origin complex	0.00422714692541711	-5.46622799920877	11	9	0.00286077558804832	3146	8202	4999,5000,5001,84515,1871,990,23595,1870,23594	ORC2,ORC4,ORC5,MCM8,E2F3,CDC6,ORC3,E2F2,ORC6
R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.00423801747951168	-5.46365969467269	85	45	0.0143038779402416	3146	8202	5599,23291,3146,257397,5604,1660,8454,4205,1147,9252,5519,5606,466,6196,3551,5601,51135,4791,7314,5598,1386,5970,4214,7311,5609,7867,51295,7335,1846,7316,5595,10392,23118,6233,1845,5608,4793,10454,79155,5594,5528,170506,6416,7334,6197	MAPK8,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,RPS6KA5,PPP2R1B,MAP2K3,ATF1,RPS6KA2,IKBKB,MAPK9,IRAK4,NFKB2,UBB,MAPK7,ATF2,RELA,MAP3K1,UBA52,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,DUSP4,UBC,MAPK3,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,DHX36,MAP2K4,UBE2N,RPS6KA3
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.00423801747951168	-5.46365969467269	85	45	0.0143038779402416	3146	8202	5599,23291,3146,257397,5604,1660,8454,4205,1147,9252,5519,5606,466,6196,3551,5601,51135,4791,7314,5598,1386,5970,4214,7311,5609,7867,51295,7335,1846,7316,5595,10392,23118,6233,1845,5608,4793,10454,79155,5594,5528,170506,6416,7334,6197	MAPK8,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,RPS6KA5,PPP2R1B,MAP2K3,ATF1,RPS6KA2,IKBKB,MAPK9,IRAK4,NFKB2,UBB,MAPK7,ATF2,RELA,MAP3K1,UBA52,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,DUSP4,UBC,MAPK3,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,DHX36,MAP2K4,UBE2N,RPS6KA3
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	0.00428244208855913	-5.45323185066908	342	155	0.0492689129052765	3146	8202	23291,7249,4763,5786,8454,5720,1026,3709,5519,5906,5696,5688,5296,5701,10818,64223,7311,9978,208,842,283455,7335,5335,5719,6233,4296,4254,5690,5527,2932,5705,409,5528,5700,2549,5689,5693,5245,7410,8649,5713,808,10256,5532,5715,1847,5062,5601,5686,5702,10892,8437,5908,5685,5605,5691,5921,5704,3708,5534,2069,6416,192669,5599,161742,200734,685,10142,9462,5683,2475,5894,8826,5879,5037,5604,2064,1147,4067,5687,4193,6464,6711,3551,23198,10213,8503,1027,253260,10768,7321,5970,7414,207,2931,5695,8452,1742,1846,3710,2260,8660,817,5529,2534,23118,5706,80824,5709,5536,9861,10454,4343,5594,7334,5711,1844,23112,673,257397,79109,5716,2309,9491,5708,117145,5781,3717,5717,2065,7314,1843,5694,6709,6199,4214,5170,5609,5692,4303,6654,3164,5295,5747,5710,7316,5595,2885,57761,997,7322,84078,152559,84292,3265	FBXW11,TSC2,NF1,PTPRA,CUL1,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,UBE2V1,PLCG1,PSMD13,RPS27A,MAP3K11,KITLG,PSMB2,PPP2R5C,GSK3B,PSMC5,ARRB2,PPP2R5D,PSMC1,GAB1,PSMB1,PSMB5,PHB,VAV2,LAMTOR3,PSMD7,CALM3,CNKSR1,PPP3CB,PSMD9,DUSP5,PAK2,MAPK9,PSMA5,PSMC3,MALT1,RASAL1,RAP1B,PSMA4,MAP2K2,PSMB3,RASA1,PSMC4,ITPR1,PPP3R1,EREG,MAP2K4,AGO3,MAPK8,SPRED1,SPRED2,BTC,AKAP9,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,RAC1,PEBP1,MAP2K1,ERBB2,CHUK,LYN,PSMA6,MDM2,SHC1,SPTBN1,IKBKB,PSME4,PSMD14,PIK3R3,CDKN1B,RICTOR,AHCYL1,UBE2D1,RELA,VCL,AKT1,GSK3A,PSMB7,CUL3,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,TAB2,PSMC6,DUSP16,PSMD3,PPP5C,PSMD6,TAB1,MOV10,MAPK1,UBE2N,PSMD5,DUSP2,TNRC6B,BRAF,TAB3,MAPKAP1,PSMD10,FOXO3,PSMF1,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,DUSP1,PSMB6,SPTAN1,RPS6KB2,MAP3K1,PDPK1,MAP2K7,PSMB4,FOXO4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,CDC34,UBE2D2,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-73856	RNA Polymerase II Transcription Termination	0.00429174457372561	-5.4510619681641	42	25	0.00794659885568976	3146	8202	9295,51362,65109,1479,134353,10250,10978,10921,6636,7884,6635,51585,6430,53981,11051,25888,29894,6427,7307,6429,1478,22916,6428,6637,84967	SRSF11,CDC40,UPF3B,CSTF3,LSM11,SRRM1,CLP1,RNPS1,SNRPF,SLBP,SNRPE,PCF11,SRSF5,CPSF2,NUDT21,ZNF473,CPSF1,SRSF2,U2AF1,SRSF4,CSTF2,NCBP2,SRSF3,SNRPG,LSM10
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.00429174457372561	-5.4510619681641	42	25	0.00794659885568976	3146	8202	3054,80205,51106,7978,2551,8841,6256,5465,6604,4209,506,11232,2553,1387,4899,23054,211,6907,6742,9611,10891,2101,5469,1386,10498	HCFC1,CHD9,TFB1M,MTERF1,GABPA,HDAC3,RXRA,PPARA,SMARCD3,MEF2D,ATP5B,POLG2,GABPB1,CREBBP,NRF1,NCOA6,ALAS1,TBL1X,SSBP1,NCOR1,PPARGC1A,ESRRA,MED1,ATF2,CARM1
R-HSA-3928662	EPHB-mediated forward signaling	0.00429174457372561	-5.4510619681641	42	25	0.00794659885568976	3146	8202	387,71,10096,5879,7525,10093,5747,10552,4067,1947,5921,2534,10092,3984,8976,60,2050,10097,6093,10109,9475,3265,6453,3985,2049	RHOA,ACTG1,ACTR3,RAC1,YES1,ARPC4,PTK2,ARPC1A,LYN,EFNB1,RASA1,FYN,ARPC5,LIMK1,WASL,ACTB,EPHB4,ACTR2,ROCK1,ARPC2,ROCK2,HRAS,ITSN1,LIMK2,EPHB3
R-HSA-109688	Cleavage of Growing Transcript in the Termination Region	0.00429174457372561	-5.4510619681641	42	25	0.00794659885568976	3146	8202	9295,51362,65109,1479,134353,10250,10978,10921,6636,7884,6635,51585,6430,53981,11051,25888,29894,6427,7307,6429,1478,22916,6428,6637,84967	SRSF11,CDC40,UPF3B,CSTF3,LSM11,SRRM1,CLP1,RNPS1,SNRPF,SLBP,SNRPE,PCF11,SRSF5,CPSF2,NUDT21,ZNF473,CPSF1,SRSF2,U2AF1,SRSF4,CSTF2,NCBP2,SRSF3,SNRPG,LSM10
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression	0.00429174457372561	-5.4510619681641	42	25	0.00794659885568976	3146	8202	2033,80205,2908,8841,6256,5465,6604,1387,23054,3091,5187,406,1408,1628,9611,6907,9575,10891,150094,8204,25819,1407,5469,10498,23373	EP300,CHD9,NR3C1,HDAC3,RXRA,PPARA,SMARCD3,CREBBP,NCOA6,HIF1A,PER1,ARNTL,CRY2,DBP,NCOR1,TBL1X,CLOCK,PPARGC1A,SIK1,NRIP1,NOCT,CRY1,MED1,CARM1,CRTC1
R-HSA-3214815	HDACs deacetylate histones	0.00438061728134944	-5.4305656327088	94	49	0.0155753337571519	3146	8202	57504,8367,8358,8350,85235,83933,8969,8360,23028,440689,8365,121504,54815,8366,8364,653604,1108,8345,5926,8331,92815,8819,57459,8968,8352,8336,5931,9219,8841,23186,51742,8368,8357,53615,8330,8294,25855,3012,8334,1107,2874,8351,3065,6907,9611,10284,8338,3066,8354	MTA3,HIST1H4E,HIST1H3B,HIST1H3A,HIST1H2AH,HDAC10,HIST1H2AG,HIST1H4D,KDM1A,HIST2H2BF,HIST1H4H,HIST4H4,GATAD2A,HIST1H4B,HIST1H4C,HIST2H3D,CHD4,HIST1H2BH,ARID4A,HIST1H2AJ,HIST3H2A,SAP30,GATAD2B,HIST1H3F,HIST1H3C,HIST1H2AM,RBBP7,MTA2,HDAC3,RCOR1,ARID4B,HIST1H4L,HIST1H3H,MBD3,HIST1H2AK,HIST1H4I,BRMS1,HIST1H2AE,HIST1H2AC,CHD3,GPS2,HIST1H3D,HDAC1,TBL1X,NCOR1,SAP18,HIST2H2AC,HDAC2,HIST1H3I
R-HSA-203765	eNOS activation and regulation	0.00438917832199425	-5.42861323980217	22	15	0.00476795931341386	3146	8202	23576,23564,207,2644,8976,2643,1785,1719,10434,808,5805,857,3320,51070,340481	DDAH1,DDAH2,AKT1,GCHFR,WASL,GCH1,DNM2,DHFR,LYPLA1,CALM3,PTS,CAV1,HSP90AA1,NOSIP,ZDHHC21
R-HSA-166208	mTORC1-mediated signalling	0.00438917832199425	-5.42861323980217	22	15	0.00476795931341386	3146	8202	57521,1981,2475,1978,389541,6194,10325,8649,64121,6198,1977,6009,64223,10542,58528	RPTOR,EIF4G1,MTOR,EIF4EBP1,LAMTOR4,RPS6,RRAGB,LAMTOR3,RRAGC,RPS6KB1,EIF4E,RHEB,MLST8,LAMTOR5,RRAGD
R-HSA-202131	Metabolism of nitric oxide	0.00438917832199425	-5.42861323980217	22	15	0.00476795931341386	3146	8202	23576,23564,207,2644,8976,2643,1785,1719,10434,808,5805,857,3320,51070,340481	DDAH1,DDAH2,AKT1,GCHFR,WASL,GCH1,DNM2,DHFR,LYPLA1,CALM3,PTS,CAV1,HSP90AA1,NOSIP,ZDHHC21
R-HSA-5696400	Dual Incision in GG-NER	0.00442379757114793	-5.42075677278278	40	24	0.00762873490146217	3146	8202	5984,1643,2067,5983,7311,9978,2071,8450,2072,404672,10714,5982,5424,7316,5111,5426,5427,6233,2073,5981,2068,7314,5425,1642	RFC4,DDB2,ERCC1,RFC3,UBA52,RBX1,ERCC3,CUL4B,ERCC4,GTF2H5,POLD3,RFC2,POLD1,UBC,PCNA,POLE,POLE2,RPS27A,ERCC5,RFC1,ERCC2,UBB,POLD2,DDB1
R-HSA-109703	PKB-mediated events	0.00442379757114793	-5.42075677278278	40	24	0.00762873490146217	3146	8202	7249,207,2475,208,5565,92335,5562,8649,64121,5571,6009,10542,57521,1981,51422,1978,389541,6194,10325,5494,6198,1977,64223,58528	TSC2,AKT1,MTOR,AKT2,PRKAB2,STRADA,PRKAA1,LAMTOR3,RRAGC,PRKAG1,RHEB,LAMTOR5,RPTOR,EIF4G1,PRKAG2,EIF4EBP1,LAMTOR4,RPS6,RRAGB,PPM1A,RPS6KB1,EIF4E,MLST8,RRAGD
R-HSA-74751	Insulin receptor signalling cascade	0.00443704965591986	-5.41776561532055	280	129	0.0410044500953592	3146	8202	7249,4763,5565,5786,92335,5720,5519,57521,5906,5696,5688,5296,5701,6194,5494,1977,10818,64223,7311,9978,208,5571,283455,6009,1981,5719,6233,4296,10325,4254,5527,5690,5705,409,5700,2549,5528,58528,5689,5693,5562,5245,30849,8649,5713,808,10256,5715,1847,5686,5702,5908,8437,5605,5685,5691,5921,5704,3643,51422,389541,2069,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,64121,5687,6464,6711,23198,10213,7414,207,8452,5695,1742,1846,2260,8660,817,5529,2534,5706,5709,80824,1978,6198,9861,5536,5594,5711,1844,673,5716,9491,10542,5708,117145,5781,5717,3717,2065,7314,6709,1843,5694,5170,5692,6654,5295,5747,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,NF1,PRKAB2,PTPRA,STRADA,PSME1,PPP2R1B,RPTOR,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,RPS6,PPM1A,EIF4E,FRS2,MLST8,UBA52,RBX1,AKT2,PRKAG1,KSR2,RHEB,EIF4G1,PSMD13,RPS27A,MAP3K11,RRAGB,KITLG,PPP2R5C,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,RRAGD,PSMB1,PSMB5,PRKAA1,PHB,PIK3R4,LAMTOR3,PSMD7,CALM3,CNKSR1,PSMD9,DUSP5,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,INSR,PRKAG2,LAMTOR4,EREG,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,RRAGC,PSMA6,SHC1,SPTBN1,PSME4,PSMD14,VCL,AKT1,CUL3,PSMB7,DLG4,DUSP4,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,EIF4EBP1,RPS6KB1,PSMD6,PPP5C,MAPK1,PSMD5,DUSP2,BRAF,PSMD10,PSMF1,LAMTOR5,PSMD2,THEM4,PTPN11,PSMD11,JAK2,ERBB3,UBB,SPTAN1,DUSP1,PSMB6,PDPK1,PSMB4,SOS1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.00450646983353692	-5.40224117397958	83	44	0.013986013986014	3146	8202	5599,23291,3146,257397,5604,1660,8454,4205,1147,9252,5519,5606,466,6196,3551,5601,51135,4791,7314,5598,1386,5970,4214,7311,5609,7867,51295,7335,1846,7316,5595,10392,23118,6233,1845,5608,4793,10454,79155,5594,5528,6416,7334,6197	MAPK8,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,RPS6KA5,PPP2R1B,MAP2K3,ATF1,RPS6KA2,IKBKB,MAPK9,IRAK4,NFKB2,UBB,MAPK7,ATF2,RELA,MAP3K1,UBA52,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,DUSP4,UBC,MAPK3,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,MAP2K4,UBE2N,RPS6KA3
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	0.00459218293391938	-5.38339978323237	24	16	0.00508582326764145	3146	8202	10398,391,387,3984,389,5879,4637,2064,23365,6093,4628,9475,388,5364,3985,27289	MYL9,RHOG,RHOA,LIMK1,RHOC,RAC1,MYL6,ERBB2,ARHGEF12,ROCK1,MYH10,ROCK2,RHOB,PLXNB1,LIMK2,RND1
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	0.00459218293391938	-5.38339978323237	24	16	0.00508582326764145	3146	8202	51128,10802,10427,22872,811,10484,6396,9871,9632,6890,51752,2923,567,6891,821,3105	SAR1B,SEC24A,SEC24B,SEC31A,CALR,SEC23A,SEC13,SEC24D,SEC24C,TAP1,ERAP1,PDIA3,B2M,TAP2,CANX,HLA-A
R-HSA-2559580	Oxidative Stress Induced Senescence	0.00465360618529812	-5.37011283622598	119	60	0.0190718372536554	3146	8202	5599,1030,23112,23043,3015,8367,23512,8358,8350,8360,6015,5606,8365,121504,2146,1031,4193,8366,8364,5601,84733,653604,8345,7314,1032,1021,8331,8968,8352,7311,5609,5931,7867,1871,23466,8550,22955,8368,8357,7316,5595,8294,3012,8334,6233,8351,5608,7027,3014,4217,3020,8338,1870,5594,4343,6416,8535,192669,1029,8354	MAPK8,CDKN2B,TNRC6B,TNIK,H2AFZ,HIST1H4E,SUZ12,HIST1H3B,HIST1H3A,HIST1H4D,RING1,MAP2K3,HIST1H4H,HIST4H4,EZH2,CDKN2C,MDM2,HIST1H4B,HIST1H4C,MAPK9,CBX2,HIST2H3D,HIST1H2BH,UBB,CDKN2D,CDK6,HIST1H2AJ,HIST1H3F,HIST1H3C,UBA52,MAP2K7,RBBP7,MAPKAPK3,E2F3,CBX6,MAPKAPK5,SCMH1,HIST1H4L,HIST1H3H,UBC,MAPK3,HIST1H4I,HIST1H2AE,HIST1H2AC,RPS27A,HIST1H3D,MAP2K6,TFDP1,H2AFX,MAP3K5,H3F3A,HIST2H2AC,E2F2,MAPK1,MOV10,MAP2K4,CBX4,AGO3,CDKN2A,HIST1H3I
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	0.00472233712206488	-5.35545144895261	26	17	0.00540368722186904	3146	8202	7375,10616,7128,330,257397,7186,81858,1147,10399,27005,329,7185,23118,56957,3551,55072,10454	USP4,RBCK1,TNFAIP3,BIRC3,TAB3,TRAF2,SHARPIN,CHUK,GNB2L1,USP21,BIRC2,TRAF1,TAB2,OTUD7B,IKBKB,RNF31,TAB1
R-HSA-113418	Formation of the Early Elongation Complex	0.00473056527553836	-5.3537105750484	34	21	0.0066751430387794	3146	8202	51497,9150,5438,5436,5441,7936,5440,2071,5433,404672,6829,5430,2962,5432,4331,6827,5434,2963,22916,2068,25920	NELFCD,CTDP1,POLR2I,POLR2G,POLR2L,NELFE,POLR2K,ERCC3,POLR2D,GTF2H5,SUPT5H,POLR2A,GTF2F1,POLR2C,MNAT1,SUPT4H1,POLR2E,GTF2F2,NCBP2,ERCC2,NELFB
R-HSA-177243	Interactions of Rev with host cellular proteins	0.00473056527553836	-5.3537105750484	34	21	0.0066751430387794	3146	8202	23511,8480,5905,9631,348995,8021,23165,129401,9883,7175,5903,7514,1104,5902,57122,23636,9972,5901,79902,3837,81929	NUP188,RAE1,RANGAP1,NUP155,NUP43,NUP214,NUP205,NUP35,POM121,TPR,RANBP2,XPO1,RCC1,RANBP1,NUP107,NUP62,NUP153,RAN,NUP85,KPNB1,SEH1L
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	0.00473056527553836	-5.3537105750484	34	21	0.0066751430387794	3146	8202	51497,9150,5438,5436,5441,2071,5440,7936,5433,404672,6829,5430,2962,4331,5432,6827,5434,2963,22916,2068,25920	NELFCD,CTDP1,POLR2I,POLR2G,POLR2L,ERCC3,POLR2K,NELFE,POLR2D,GTF2H5,SUPT5H,POLR2A,GTF2F1,MNAT1,POLR2C,SUPT4H1,POLR2E,GTF2F2,NCBP2,ERCC2,NELFB
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	0.00478688342906497	-5.34187572043189	32	20	0.00635727908455181	3146	8202	23511,8480,5905,9631,348995,8021,23165,129401,9883,7175,5903,7514,1104,5902,57122,23636,9972,5901,79902,81929	NUP188,RAE1,RANGAP1,NUP155,NUP43,NUP214,NUP205,NUP35,POM121,TPR,RANBP2,XPO1,RCC1,RANBP1,NUP107,NUP62,NUP153,RAN,NUP85,SEH1L
R-HSA-381042	PERK regulates gene expression	0.00479136189307355	-5.34094058791349	28	18	0.00572155117609663	3146	8202	23404,468,118460,51010,9451,467,5393,5073,9709,23016,440,56915,4802,1965,8570,54512,4801,1649	EXOSC2,ATF4,EXOSC6,EXOSC3,EIF2AK3,ATF3,EXOSC9,PARN,HERPUD1,EXOSC7,ASNS,EXOSC5,NFYC,EIF2S1,KHSRP,EXOSC4,NFYB,DDIT3
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	0.00480979961013458	-5.337099856827	30	19	0.00603941513032422	3146	8202	142678,6868,54567,7311,102,51107,83737,54492,83464,7316,57534,182,6233,5664,23220,7314,409,23385,8650	MIB2,ADAM17,DLL4,UBA52,ADAM10,APH1A,ITCH,NEURL1B,APH1B,UBC,MIB1,JAG1,RPS27A,PSEN2,DTX4,UBB,ARRB2,NCSTN,NUMB
R-HSA-204005	COPII (Coat Protein 2) Mediated Vesicle Transport	0.0053398282848712	-5.23256178291822	66	36	0.0114431023521933	3146	8202	6396,7109,9871,26984,10652,9919,9117,966,1075,9632,81562,81876,10342,3998,22870,6811,10113,10802,10484,83696,23256,7039,10282,1294,5861,122553,51693,22872,51128,10427,27095,63908,9554,55291,8775,79090	SEC13,TRAPPC10,SEC24D,SEC22A,YKT6,SEC16A,SEC22C,CD59,CTSC,SEC24C,LMAN2L,RAB1B,TFG,LMAN1,PPP6R1,STX5,PREB,SEC24A,SEC23A,TRAPPC9,SCFD1,TGFA,BET1,COL7A1,RAB1A,TRAPPC6B,TRAPPC2L,SEC31A,SAR1B,SEC24B,TRAPPC3,NAPB,SEC22B,PPP6R3,NAPA,TRAPPC6A
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	0.0053398282848712	-5.23256178291822	66	36	0.0114431023521933	3146	8202	2033,3146,29110,7311,51428,5441,5440,5591,171568,1660,84265,1147,3661,51728,11128,7316,7520,1387,1499,6233,6778,3551,5434,23220,27297,4361,6737,148022,55703,4793,9533,4791,7314,5970,170506,10621	EP300,HMGB1,TBK1,UBA52,DDX41,POLR2L,POLR2K,PRKDC,POLR3H,DHX9,POLR3GL,CHUK,IRF3,POLR3K,POLR3A,UBC,XRCC5,CREBBP,CTNNB1,RPS27A,STAT6,IKBKB,POLR2E,DTX4,CRCP,MRE11A,TRIM21,TICAM1,POLR3B,NFKBIB,POLR1C,NFKB2,UBB,RELA,DHX36,POLR3F
R-HSA-2046104	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	0.00545414230310594	-5.21137990338721	13	10	0.00317863954227591	3146	8202	60481,2180,51,83401,6342,215,3295,30,64834,10005	ELOVL5,ACSL1,ACOX1,ELOVL3,SCP2,ABCD1,HSD17B4,ACAA1,ELOVL1,ACOT8
R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	0.00545414230310594	-5.21137990338721	13	10	0.00317863954227591	3146	8202	60481,2180,51,83401,6342,215,3295,30,64834,10005	ELOVL5,ACSL1,ACOX1,ELOVL3,SCP2,ABCD1,HSD17B4,ACAA1,ELOVL1,ACOT8
R-HSA-198323	AKT phosphorylates targets in the cytosol	0.00545414230310594	-5.21137990338721	13	10	0.00317863954227591	3146	8202	4193,2931,207,7249,208,842,2932,1027,1147,1026	MDM2,GSK3A,AKT1,TSC2,AKT2,CASP9,GSK3B,CDKN1B,CHUK,CDKN1A
R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	0.00545414230310594	-5.21137990338721	13	10	0.00317863954227591	3146	8202	7311,207,6233,208,10193,9101,2064,2065,7314,7316	UBA52,AKT1,RPS27A,AKT2,RNF41,USP8,ERBB2,ERBB3,UBB,UBC
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	0.00563494909488029	-5.17876716527028	86	45	0.0143038779402416	3146	8202	10163,8936,71,5879,10096,7410,10093,3709,4067,4641,5581,25,55845,63916,10092,5296,51517,3320,10097,10768,147179,8398,10152,23191,4690,4651,3326,5295,5747,7525,3710,10552,10458,5595,2885,5335,2534,1398,8976,3984,3708,60,5337,10109,5594	WASF2,WASF1,ACTG1,RAC1,ACTR3,VAV2,ARPC4,ITPR2,LYN,MYO1C,PRKCE,ABL1,BRK1,ELMO2,ARPC5,PIK3R2,NCKIPSD,HSP90AA1,ACTR2,AHCYL1,WIPF2,PLA2G6,ABI2,CYFIP1,NCK1,MYO10,HSP90AB1,PIK3R1,PTK2,YES1,ITPR3,ARPC1A,BAIAP2,MAPK3,GRB2,PLCG1,FYN,CRK,WASL,LIMK1,ITPR1,ACTB,PLD1,ARPC2,MAPK1
R-HSA-68875	Mitotic Prophase	0.00583927259761433	-5.14314904510267	136	67	0.0212968849332486	3146	8202	3015,23511,2029,5862,8358,8350,348995,64900,891,5519,8365,8366,8364,57122,9972,8331,81929,7112,8352,23133,9631,10592,5861,8021,983,8294,5903,8351,7444,91754,3014,3020,8338,5594,255919,8367,8480,4000,129401,23165,9883,8360,121504,2010,387893,81876,653604,8345,29781,79902,10051,8968,140609,8368,8357,5595,84930,221496,7175,8334,23310,3012,23592,6418,23636,9133,8354	H2AFZ,NUP188,ENSA,RAB2A,HIST1H3B,HIST1H3A,NUP43,LPIN3,CCNB1,PPP2R1B,HIST1H4H,HIST1H4B,HIST1H4C,NUP107,NUP153,HIST1H2AJ,SEH1L,TMPO,HIST1H3C,PHF8,NUP155,SMC2,RAB1A,NUP214,CDK1,HIST1H4I,RANBP2,HIST1H3D,VRK2,NEK9,H2AFX,H3F3A,HIST2H2AC,MAPK1,CNEP1R1,HIST1H4E,RAE1,LMNA,NUP35,NUP205,POM121,HIST1H4D,HIST4H4,EMD,KMT5A,RAB1B,HIST2H3D,HIST1H2BH,NCAPH2,NUP85,SMC4,HIST1H3F,NEK7,HIST1H4L,HIST1H3H,MAPK3,MASTL,LEMD2,TPR,HIST1H2AC,NCAPD3,HIST1H2AE,LEMD3,SET,NUP62,CCNB2,HIST1H3I
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	0.00598679950369721	-5.1181983162088	62	34	0.0108073744437381	3146	8202	51552,6517,5565,5879,808,23265,7531,8766,4641,4218,79058,57148,149371,57186,55770,23433,207,5872,208,5571,10971,6810,10640,10890,7532,5898,51422,8773,60412,11127,7534,9882,7533,2810	RAB14,SLC2A4,PRKAB2,RAC1,CALM3,EXOC7,YWHAE,RAB11A,MYO1C,RAB8A,ASPSCR1,RALGAPB,EXOC8,RALGAPA2,EXOC2,RHOQ,AKT1,RAB13,AKT2,PRKAG1,YWHAQ,STX4,EXOC5,RAB10,YWHAG,RALA,PRKAG2,SNAP23,EXOC4,KIF3A,YWHAZ,TBC1D4,YWHAH,SFN
R-HSA-2691232	Constitutive Signaling by NOTCH1 HD Domain Mutants	0.00641909700271181	-5.04847782495615	15	11	0.0034965034965035	3146	8202	142678,6868,54567,182,7311,102,6233,7314,54492,7316,57534	MIB2,ADAM17,DLL4,JAG1,UBA52,ADAM10,RPS27A,UBB,NEURL1B,UBC,MIB1
R-HSA-901042	Calnexin/calreticulin cycle	0.00641909700271181	-5.04847782495615	15	11	0.0034965034965035	3146	8202	811,5589,51009,9695,80267,2923,55757,56886,84447,821,55741	CALR,PRKCSH,DERL2,EDEM1,EDEM3,PDIA3,UGGT2,UGGT1,SYVN1,CANX,EDEM2
R-HSA-205043	NRIF signals cell death from the nucleus	0.00641909700271181	-5.04847782495615	15	11	0.0034965034965035	3146	8202	5599,7311,23421,8878,51107,6233,5664,7314,83464,23385,7316	MAPK8,UBA52,ITGB3BP,SQSTM1,APH1A,RPS27A,PSEN2,UBB,APH1B,NCSTN,UBC
R-HSA-2691230	Signaling by NOTCH1 HD Domain Mutants in Cancer	0.00641909700271181	-5.04847782495615	15	11	0.0034965034965035	3146	8202	142678,6868,54567,182,7311,102,6233,7314,54492,7316,57534	MIB2,ADAM17,DLL4,JAG1,UBA52,ADAM10,RPS27A,UBB,NEURL1B,UBC,MIB1
R-HSA-5620924	Intraflagellar transport	0.00683315279140033	-4.9859691026256	41	24	0.00762873490146217	3146	8202	64792,55081,51098,8655,92104,26160,89891,9321,80173,11020,150737,57560,28981,51668,83657,79989,55764,26146,57728,11127,55112,6991,79659,3842	IFT22,IFT57,IFT52,DYNLL1,TTC30A,IFT172,WDR34,TRIP11,IFT74,IFT27,TTC30B,IFT80,IFT81,HSPB11,DYNLRB2,TTC26,IFT122,TRAF3IP1,WDR19,KIF3A,WDR60,TCTE3,DYNC2H1,TNPO1
R-HSA-5656121	Translesion synthesis by POLI	0.00713996432080019	-4.94204749972994	17	12	0.00381436745073109	3146	8202	5984,5980,5111,5983,7311,6233,5981,7314,5982,51455,10459,7316	RFC4,REV3L,PCNA,RFC3,UBA52,RPS27A,RFC1,UBB,RFC2,REV1,MAD2L2,UBC
R-HSA-5655862	Translesion synthesis by POLK	0.00713996432080019	-4.94204749972994	17	12	0.00381436745073109	3146	8202	5984,5980,5111,5983,7311,6233,5981,7314,5982,51455,10459,7316	RFC4,REV3L,PCNA,RFC3,UBA52,RPS27A,RFC1,UBB,RFC2,REV1,MAD2L2,UBC
R-HSA-2428924	IGF1R signaling cascade	0.0072885352771608	-4.9214526753493	281	128	0.0406865861411316	3146	8202	161742,10142,685,200734,7249,9462,2475,4763,5683,5565,5786,8826,92335,5894,5037,5604,64121,2064,5720,5519,57521,5906,5696,5687,6464,5688,6711,5296,5701,6194,10213,23198,5494,7414,1977,10818,64223,7311,207,9978,208,5695,8452,1742,5571,283455,1846,2260,6009,8660,5529,1981,817,2534,5719,6233,5706,1978,80824,5709,4296,10325,4254,5527,5690,6198,5705,5536,9861,409,5594,5700,2549,5528,5711,58528,1844,5689,5693,673,5562,5245,30849,8649,5713,808,5716,10256,5715,9491,1847,10542,5708,117145,5781,3717,5717,2065,7314,5686,5694,1843,6709,5170,5692,6654,5295,5702,5908,8437,5747,5710,5605,5685,5691,7316,5921,5595,5704,2885,57761,51422,389541,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,TSC2,RASAL2,MTOR,NF1,PSMA2,PRKAB2,PTPRA,IQGAP1,STRADA,RAF1,PEBP1,MAP2K1,RRAGC,ERBB2,PSME1,PPP2R1B,RPTOR,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PIK3R2,PSMC2,RPS6,PSMD14,PSME4,PPM1A,VCL,EIF4E,FRS2,MLST8,UBA52,AKT1,RBX1,AKT2,PSMB7,CUL3,DLG4,PRKAG1,KSR2,DUSP4,FGFR1,RHEB,IRS2,PPP2R5E,EIF4G1,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,EIF4EBP1,DUSP16,PSMD3,MAP3K11,RRAGB,KITLG,PPP2R5C,PSMB2,RPS6KB1,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,GAB1,PPP2R5D,PSMD5,RRAGD,DUSP2,PSMB1,PSMB5,BRAF,PRKAA1,PHB,PIK3R4,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,PSMF1,DUSP5,LAMTOR5,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,PSMA5,PSMB6,DUSP1,SPTAN1,PDPK1,PSMB4,SOS1,PIK3R1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,TRIB3,PRKAG2,LAMTOR4,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-2428928	IRS-related events triggered by IGF1R	0.0072885352771608	-4.9214526753493	281	128	0.0406865861411316	3146	8202	161742,10142,685,200734,7249,9462,2475,4763,5683,5565,5786,8826,92335,5894,5037,5604,64121,2064,5720,5519,57521,5906,5696,5687,6464,5688,6711,5296,5701,6194,10213,23198,5494,7414,1977,10818,64223,7311,207,9978,208,5695,8452,1742,5571,283455,1846,2260,6009,8660,5529,1981,817,2534,5719,6233,5706,1978,80824,5709,4296,10325,4254,5527,5690,6198,5705,5536,9861,409,5594,5700,2549,5528,5711,58528,1844,5689,5693,673,5562,5245,30849,8649,5713,808,5716,10256,5715,9491,1847,10542,5708,117145,5781,3717,5717,2065,7314,5686,5694,1843,6709,5170,5692,6654,5295,5702,5908,8437,5747,5710,5605,5685,5691,7316,5921,5595,5704,2885,57761,51422,389541,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,TSC2,RASAL2,MTOR,NF1,PSMA2,PRKAB2,PTPRA,IQGAP1,STRADA,RAF1,PEBP1,MAP2K1,RRAGC,ERBB2,PSME1,PPP2R1B,RPTOR,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PIK3R2,PSMC2,RPS6,PSMD14,PSME4,PPM1A,VCL,EIF4E,FRS2,MLST8,UBA52,AKT1,RBX1,AKT2,PSMB7,CUL3,DLG4,PRKAG1,KSR2,DUSP4,FGFR1,RHEB,IRS2,PPP2R5E,EIF4G1,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,EIF4EBP1,DUSP16,PSMD3,MAP3K11,RRAGB,KITLG,PPP2R5C,PSMB2,RPS6KB1,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,GAB1,PPP2R5D,PSMD5,RRAGD,DUSP2,PSMB1,PSMB5,BRAF,PRKAA1,PHB,PIK3R4,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,PSMF1,DUSP5,LAMTOR5,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,PSMA5,PSMB6,DUSP1,SPTAN1,PDPK1,PSMB4,SOS1,PIK3R1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,TRIB3,PRKAG2,LAMTOR4,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.0072885352771608	-4.9214526753493	281	128	0.0406865861411316	3146	8202	161742,10142,685,200734,7249,9462,2475,4763,5683,5565,5786,8826,92335,5894,5037,5604,64121,2064,5720,5519,57521,5906,5696,5687,6464,5688,6711,5296,5701,6194,10213,23198,5494,7414,1977,10818,64223,7311,207,9978,208,5695,8452,1742,5571,283455,1846,2260,6009,8660,5529,1981,817,2534,5719,6233,5706,1978,80824,5709,4296,10325,4254,5527,5690,6198,5705,5536,9861,409,5594,5700,2549,5528,5711,58528,1844,5689,5693,673,5562,5245,30849,8649,5713,808,5716,10256,5715,9491,1847,10542,5708,117145,5781,3717,5717,2065,7314,5686,5694,1843,6709,5170,5692,6654,5295,5702,5908,8437,5747,5710,5605,5685,5691,7316,5921,5595,5704,2885,57761,51422,389541,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,TSC2,RASAL2,MTOR,NF1,PSMA2,PRKAB2,PTPRA,IQGAP1,STRADA,RAF1,PEBP1,MAP2K1,RRAGC,ERBB2,PSME1,PPP2R1B,RPTOR,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PIK3R2,PSMC2,RPS6,PSMD14,PSME4,PPM1A,VCL,EIF4E,FRS2,MLST8,UBA52,AKT1,RBX1,AKT2,PSMB7,CUL3,DLG4,PRKAG1,KSR2,DUSP4,FGFR1,RHEB,IRS2,PPP2R5E,EIF4G1,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,EIF4EBP1,DUSP16,PSMD3,MAP3K11,RRAGB,KITLG,PPP2R5C,PSMB2,RPS6KB1,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,GAB1,PPP2R5D,PSMD5,RRAGD,DUSP2,PSMB1,PSMB5,BRAF,PRKAA1,PHB,PIK3R4,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,PSMF1,DUSP5,LAMTOR5,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,PSMA5,PSMB6,DUSP1,SPTAN1,PDPK1,PSMB4,SOS1,PIK3R1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,TRIB3,PRKAG2,LAMTOR4,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-73886	Chromosome Maintenance	0.00731699955197039	-4.91755493231157	105	53	0.0168467895740623	3146	8202	3015,55355,8367,54069,201254,3978,51773,5424,55320,8360,8365,121504,54386,5111,65057,8366,8364,1763,26277,55166,8345,79019,8331,5984,1058,5983,328,5558,5931,5422,64105,1736,8368,10714,5982,79682,5557,401541,8294,3012,8334,5426,5427,23421,3014,10856,5981,8467,8338,57082,7013,5425,55135	H2AFZ,HJURP,HIST1H4E,MIS18A,STRA13,LIG1,RSF1,POLD1,MIS18BP1,HIST1H4D,HIST1H4H,HIST4H4,TERF2IP,PCNA,ACD,HIST1H4B,HIST1H4C,DNA2,TINF2,CENPQ,HIST1H2BH,CENPM,HIST1H2AJ,RFC4,CENPA,RFC3,APEX1,PRIM2,RBBP7,POLA1,CENPK,DKC1,HIST1H4L,POLD3,RFC2,CENPU,PRIM1,CENPP,HIST1H4I,HIST1H2AE,HIST1H2AC,POLE,POLE2,ITGB3BP,H2AFX,RUVBL2,RFC1,SMARCA5,HIST2H2AC,CASC5,TERF1,POLD2,WRAP53
R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	0.00734152024640214	-4.91420933976325	67	36	0.0114431023521933	3146	8202	9945,4351,64841,10825,6480,79087,10020,79053,1798,54344,5373,8818,6484,79868,22845,5238,144245,56052,2673,79796,8813,256435,26503,10610,91869,29926,6487,79947,10195,5372,199857,29925,440138,2720,85365,6482	GFPT2,MPI,GNPNAT1,NEU3,ST6GAL1,ALG12,GNE,ALG8,DPAGT1,DPM3,PMM2,DPM2,ST3GAL4,ALG13,DOLK,PGM3,ALG10B,ALG1,GFPT1,ALG9,DPM1,ST6GALNAC3,SLC17A5,ST6GALNAC2,RFT1,GMPPA,ST3GAL3,DHDDS,ALG3,PMM1,ALG14,GMPPB,ALG11,GLB1,ALG2,ST3GAL1
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.0073734708458865	-4.90986674118542	121	60	0.0190718372536554	3146	8202	5599,7323,23291,3146,26052,257397,5604,1660,8454,4205,1147,3661,9252,329,5519,5606,466,6196,8651,10010,3551,5601,51135,5781,1785,4791,841,7321,7314,5598,1386,5970,4214,29110,7311,5609,330,7867,51295,7335,1846,10333,7316,5595,10392,23118,1845,6233,5608,7322,148022,4793,10454,79155,5594,5528,6416,7334,6197,114609	MAPK8,UBE2D3,FBXW11,HMGB1,DNM3,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,IRF3,RPS6KA5,BIRC2,PPP2R1B,MAP2K3,ATF1,RPS6KA2,SOCS1,TANK,IKBKB,MAPK9,IRAK4,PTPN11,DNM2,NFKB2,CASP8,UBE2D1,UBB,MAPK7,ATF2,RELA,MAP3K1,TBK1,UBA52,MAP2K7,BIRC3,MAPKAPK3,ECSIT,UBE2V1,DUSP4,TLR6,UBC,MAPK3,NOD1,TAB2,DUSP3,RPS27A,MAP2K6,UBE2D2,TICAM1,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,MAP2K4,UBE2N,RPS6KA3,TIRAP
R-HSA-186763	Downstream signal transduction	0.00740784736327291	-4.90521538616034	322	145	0.0460902733630006	3146	8202	7249,4763,5786,6777,5720,1026,3709,5519,5906,5696,5688,5296,5701,10818,5567,64223,7311,4690,9978,208,842,283455,5335,1398,5719,6233,4296,4254,5527,2932,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,814,808,10256,5715,1847,5581,5686,5702,5908,8437,5605,5685,5691,5921,5704,2886,3708,2069,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,1147,5566,1399,5687,4193,6464,6711,115,23198,10213,1027,8503,253260,10768,7414,207,2931,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,5709,80824,6778,9861,5536,4343,5594,5711,1844,23112,673,5716,79109,2309,9491,5708,117145,5781,3717,5717,2065,7314,6774,6199,6709,1843,5694,5170,4303,5692,6654,3164,5295,5747,5710,9564,7316,5595,2885,57761,84078,152559,6776,84292,3265	TSC2,NF1,PTPRA,STAT5B,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,NCK1,RBX1,AKT2,CASP9,KSR2,PLCG1,CRK,PSMD13,RPS27A,MAP3K11,KITLG,PPP2R5C,GSK3B,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,PRKCE,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,GRB7,ITPR1,EREG,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,CRKL,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,AHCYL1,VCL,AKT1,GSK3A,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,STAT6,PSMD6,PPP5C,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,PSMD10,MAPKAP1,FOXO3,PSMF1,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,STAT3,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,BCAR1,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,STAT5A,WDR83,HRAS
R-HSA-73933	Resolution of Abasic Sites (AP sites)	0.00759701772483602	-4.87999951332753	35	21	0.0066751430387794	3146	8202	23583,5984,5983,328,3978,11284,3980,4350,10714,5982,5424,252969,79661,6996,5111,5427,5426,7374,5981,4595,5425	SMUG1,RFC4,RFC3,APEX1,LIG1,PNKP,LIG3,MPG,POLD3,RFC2,POLD1,NEIL2,NEIL1,TDG,PCNA,POLE2,POLE,UNG,RFC1,MUTYH,POLD2
R-HSA-73884	Base Excision Repair	0.00759701772483602	-4.87999951332753	35	21	0.0066751430387794	3146	8202	23583,5984,5983,328,3978,11284,3980,4350,10714,5982,5424,252969,79661,6996,5111,5427,5426,7374,5981,4595,5425	SMUG1,RFC4,RFC3,APEX1,LIG1,PNKP,LIG3,MPG,POLD3,RFC2,POLD1,NEIL2,NEIL1,TDG,PCNA,POLE2,POLE,UNG,RFC1,MUTYH,POLD2
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	0.00781460963287197	-4.85176026736436	33	20	0.00635727908455181	3146	8202	23511,140609,8480,9631,348995,891,8021,983,9883,23165,129401,7175,5903,91754,57122,23636,9972,9133,79902,81929	NUP188,NEK7,RAE1,NUP155,NUP43,CCNB1,NUP214,CDK1,POM121,NUP205,NUP35,TPR,RANBP2,NEK9,NUP107,NUP62,NUP153,CCNB2,NUP85,SEH1L
R-HSA-69190	DNA strand elongation	0.00781460963287197	-4.85176026736436	33	20	0.00635727908455181	3146	8202	9837,5984,4175,5983,328,5558,5422,3978,10714,5982,5424,84296,5557,8318,5111,1763,84515,5981,4172,5425	GINS1,RFC4,MCM6,RFC3,APEX1,PRIM2,POLA1,LIG1,POLD3,RFC2,POLD1,GINS4,PRIM1,CDC45,PCNA,DNA2,MCM8,RFC1,MCM3,POLD2
R-HSA-389357	CD28 dependent PI3K/Akt signaling	0.00798339568152562	-4.83039143402938	21	14	0.00445009535918627	3146	8202	5170,57761,2534,207,2475,208,5296,5295,117145,79109,8503,253260,9020,64223	PDPK1,TRIB3,FYN,AKT1,MTOR,AKT2,PIK3R2,PIK3R1,THEM4,MAPKAP1,PIK3R3,RICTOR,MAP3K14,MLST8
R-HSA-69186	Lagging Strand Synthesis	0.00798339568152562	-4.83039143402938	21	14	0.00445009535918627	3146	8202	5984,5111,5983,328,5558,5422,1763,3978,5981,10714,5424,5982,5425,5557	RFC4,PCNA,RFC3,APEX1,PRIM2,POLA1,DNA2,LIG1,RFC1,POLD3,POLD1,RFC2,POLD2,PRIM1
R-HSA-70263	Gluconeogenesis	0.0080005746676907	-4.82824190642086	31	19	0.00603941513032422	3146	8202	2597,2026,4191,8604,5566,5091,2806,230,226,2027,1468,8402,5224,4190,5106,5223,5567,7167,6576	GAPDH,ENO2,MDH2,SLC25A12,PRKACA,PC,GOT2,ALDOC,ALDOA,ENO3,SLC25A10,SLC25A11,PGAM2,MDH1,PCK2,PGAM1,PRKACB,TPI1,SLC25A1
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	0.0080005746676907	-4.82824190642086	31	19	0.00603941513032422	3146	8202	23511,8480,9631,348995,8021,3303,23165,129401,9883,3304,7175,5903,7514,57122,9972,23636,5901,79902,81929	NUP188,RAE1,NUP155,NUP43,NUP214,HSPA1A,NUP205,NUP35,POM121,HSPA1B,TPR,RANBP2,XPO1,NUP107,NUP153,NUP62,RAN,NUP85,SEH1L
R-HSA-73980	RNA Polymerase III Transcription Termination	0.008173651930365	-4.80683947728097	23	15	0.00476795931341386	3146	8202	5441,5440,171568,5434,4774,27297,84265,4782,6741,55703,9533,4781,51728,11128,10621	POLR2L,POLR2K,POLR3H,POLR2E,NFIA,CRCP,POLR3GL,NFIC,SSB,POLR3B,POLR1C,NFIB,POLR3K,POLR3A,POLR3F
R-HSA-75067	Processing of Capped Intronless Pre-mRNA	0.008173651930365	-4.80683947728097	23	15	0.00476795931341386	3146	8202	29894,25888,11051,1479,134353,10978,6636,7884,1478,22916,6635,51585,6637,53981,84967	CPSF1,ZNF473,NUDT21,CSTF3,LSM11,CLP1,SNRPF,SLBP,CSTF2,NCBP2,SNRPE,PCF11,SNRPG,CPSF2,LSM10
R-HSA-112409	RAF-independent MAPK1/3 activation	0.008173651930365	-4.80683947728097	23	15	0.00476795931341386	3146	8202	1844,3572,80824,3569,5781,5604,3717,1846,5594,7297,983,1847,5605,5595,1843	DUSP2,IL6ST,DUSP16,IL6,PTPN11,MAP2K1,JAK2,DUSP4,MAPK1,TYK2,CDK1,DUSP5,MAP2K2,MAPK3,DUSP1
R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	0.00822197501187337	-4.80094482968969	74	39	0.012396694214876	3146	8202	51588,23511,7508,8480,79677,348995,9656,641,23165,6015,129401,9883,7341,9126,6996,6672,51564,84733,57122,9972,79902,81929,10274,10735,22955,9631,672,8021,56160,7175,5903,286053,197370,8243,9063,493861,23636,8535,1029	PIAS4,NUP188,XPC,RAE1,SMC6,NUP43,MDC1,BLM,NUP205,RING1,NUP35,POM121,SUMO1,SMC3,TDG,SP100,HDAC7,CBX2,NUP107,NUP153,NUP85,SEH1L,STAG1,STAG2,SCMH1,NUP155,BRCA1,NUP214,NDNL2,TPR,RANBP2,NSMCE2,NSMCE1,SMC1A,PIAS2,EID3,NUP62,CBX4,CDKN2A
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	0.00822197501187337	-4.80094482968969	74	39	0.012396694214876	3146	8202	51588,23511,7508,8480,79677,348995,9656,641,23165,6015,129401,9883,7341,9126,6996,6672,51564,84733,57122,9972,79902,81929,10274,10735,22955,9631,672,8021,56160,7175,5903,286053,197370,8243,9063,493861,23636,8535,1029	PIAS4,NUP188,XPC,RAE1,SMC6,NUP43,MDC1,BLM,NUP205,RING1,NUP35,POM121,SUMO1,SMC3,TDG,SP100,HDAC7,CBX2,NUP107,NUP153,NUP85,SEH1L,STAG1,STAG2,SCMH1,NUP155,BRCA1,NUP214,NDNL2,TPR,RANBP2,NSMCE2,NSMCE1,SMC1A,PIAS2,EID3,NUP62,CBX4,CDKN2A
R-HSA-400685	Sema4D in semaphorin signaling	0.00823229597563654	-4.79969032681629	27	17	0.00540368722186904	3146	8202	10398,391,387,6237,389,5879,2064,23365,4628,388,5364,27289,3984,4637,6093,9475,3985	MYL9,RHOG,RHOA,RRAS,RHOC,RAC1,ERBB2,ARHGEF12,MYH10,RHOB,PLXNB1,RND1,LIMK1,MYL6,ROCK1,ROCK2,LIMK2
R-HSA-1368082	RORA activates gene expression	0.00823229597563654	-4.79969032681629	27	17	0.00540368722186904	3146	8202	23411,2033,80205,8841,6256,5465,6604,1387,23054,406,9611,6907,10891,9575,5469,8204,10498	SIRT1,EP300,CHD9,HDAC3,RXRA,PPARA,SMARCD3,CREBBP,NCOA6,ARNTL,NCOR1,TBL1X,PPARGC1A,CLOCK,MED1,NRIP1,CARM1
R-HSA-163125	Post-translational modification: synthesis of GPI-anchored proteins	0.00824868555989675	-4.79770141740242	25	16	0.00508582326764145	3146	8202	5279,284098,8813,10026,5283,54344,84720,9487,80055,5281,8818,51227,54872,9488,8733,55650	PIGC,PIGW,DPM1,PIGK,PIGH,DPM3,PIGO,PIGL,PGAP1,PIGF,DPM2,PIGP,PIGG,PIGB,GPAA1,PIGV
R-HSA-380994	ATF4 activates genes	0.00824868555989675	-4.79770141740242	25	16	0.00508582326764145	3146	8202	23404,468,118460,51010,467,5393,5073,9709,23016,440,56915,4802,8570,54512,4801,1649	EXOSC2,ATF4,EXOSC6,EXOSC3,ATF3,EXOSC9,PARN,HERPUD1,EXOSC7,ASNS,EXOSC5,NFYC,KHSRP,EXOSC4,NFYB,DDIT3
R-HSA-446205	Synthesis of GDP-mannose	0.00828596772887655	-4.79319182999097	5	5	0.00158931977113795	3146	8202	29925,5372,4351,5373,29926	GMPPB,PMM1,MPI,PMM2,GMPPA
R-HSA-69478	G2/M DNA replication checkpoint	0.00828596772887655	-4.79319182999097	5	5	0.00158931977113795	3146	8202	7465,9088,891,9133,983	WEE1,PKMYT1,CCNB1,CCNB2,CDK1
R-HSA-191859	snRNP Assembly	0.00833546334096154	-4.78723617452701	50	28	0.00890019071837254	3146	8202	23511,8480,6636,9631,79084,6635,348995,8487,8021,9883,23165,129401,1207,25929,7175,5903,57122,79833,23636,9972,22916,50628,6637,10419,6633,51808,79902,81929	NUP188,RAE1,SNRPF,NUP155,WDR77,SNRPE,NUP43,GEMIN2,NUP214,POM121,NUP205,NUP35,CLNS1A,GEMIN5,TPR,RANBP2,NUP107,GEMIN6,NUP62,NUP153,NCBP2,GEMIN4,SNRPG,PRMT5,SNRPD2,PHAX,NUP85,SEH1L
R-HSA-194441	Metabolism of non-coding RNA	0.00833546334096154	-4.78723617452701	50	28	0.00890019071837254	3146	8202	23511,8480,6636,9631,79084,6635,348995,8487,8021,9883,23165,129401,1207,25929,7175,5903,57122,79833,23636,9972,22916,50628,6637,10419,6633,51808,79902,81929	NUP188,RAE1,SNRPF,NUP155,WDR77,SNRPE,NUP43,GEMIN2,NUP214,POM121,NUP205,NUP35,CLNS1A,GEMIN5,TPR,RANBP2,NUP107,GEMIN6,NUP62,NUP153,NCBP2,GEMIN4,SNRPG,PRMT5,SNRPD2,PHAX,NUP85,SEH1L
R-HSA-2980766	Nuclear Envelope Breakdown	0.00833546334096154	-4.78723617452701	50	28	0.00890019071837254	3146	8202	23511,140609,8480,9631,348995,64900,891,8021,983,9883,23165,129401,4000,221496,7175,5903,2010,23592,57122,7444,91754,23636,9972,9133,255919,79902,81929,7112	NUP188,NEK7,RAE1,NUP155,NUP43,LPIN3,CCNB1,NUP214,CDK1,POM121,NUP205,NUP35,LMNA,LEMD2,TPR,RANBP2,EMD,LEMD3,NUP107,VRK2,NEK9,NUP62,NUP153,CCNB2,CNEP1R1,NUP85,SEH1L,TMPO
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	0.00833546334096154	-4.78723617452701	50	28	0.00890019071837254	3146	8202	9295,51362,23511,65109,8480,10250,10921,10482,9631,348995,6430,8021,9883,23165,129401,7175,5903,6427,7307,6429,57122,23636,9972,22916,6428,1977,79902,81929	SRSF11,CDC40,NUP188,UPF3B,RAE1,SRRM1,RNPS1,NXF1,NUP155,NUP43,SRSF5,NUP214,POM121,NUP205,NUP35,TPR,RANBP2,SRSF2,U2AF1,SRSF4,NUP107,NUP62,NUP153,NCBP2,SRSF3,EIF4E,NUP85,SEH1L
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	0.00843971431428496	-4.77480681996553	92	47	0.0149396058486968	3146	8202	5599,23291,3146,257397,5604,1660,8454,4205,1147,9252,5519,5606,466,6196,8651,3551,5601,51135,4791,7314,5598,1386,5970,4214,7311,5609,7867,51295,7335,1846,10333,7316,5595,10392,23118,6233,1845,5608,4793,10454,79155,5594,5528,6416,7334,6197,114609	MAPK8,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,RPS6KA5,PPP2R1B,MAP2K3,ATF1,RPS6KA2,SOCS1,IKBKB,MAPK9,IRAK4,NFKB2,UBB,MAPK7,ATF2,RELA,MAP3K1,UBA52,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,DUSP4,TLR6,UBC,MAPK3,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,MAP2K4,UBE2N,RPS6KA3,TIRAP
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.00843971431428496	-4.77480681996553	92	47	0.0149396058486968	3146	8202	5599,23291,3146,257397,5604,1660,8454,4205,1147,9252,5519,5606,466,6196,8651,3551,5601,51135,4791,7314,5598,1386,5970,4214,7311,5609,7867,51295,7335,1846,10333,7316,5595,10392,23118,6233,1845,5608,4793,10454,79155,5594,5528,6416,7334,6197,114609	MAPK8,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,RPS6KA5,PPP2R1B,MAP2K3,ATF1,RPS6KA2,SOCS1,IKBKB,MAPK9,IRAK4,NFKB2,UBB,MAPK7,ATF2,RELA,MAP3K1,UBA52,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,DUSP4,TLR6,UBC,MAPK3,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,MAP2K4,UBE2N,RPS6KA3,TIRAP
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.00843971431428496	-4.77480681996553	92	47	0.0149396058486968	3146	8202	5599,23291,3146,257397,5604,1660,8454,4205,1147,9252,5519,5606,466,6196,8651,3551,5601,51135,4791,7314,5598,1386,5970,4214,7311,5609,7867,51295,7335,1846,10333,7316,5595,10392,23118,6233,1845,5608,4793,10454,79155,5594,5528,6416,7334,6197,114609	MAPK8,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,RPS6KA5,PPP2R1B,MAP2K3,ATF1,RPS6KA2,SOCS1,IKBKB,MAPK9,IRAK4,NFKB2,UBB,MAPK7,ATF2,RELA,MAP3K1,UBA52,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,DUSP4,TLR6,UBC,MAPK3,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,MAP2K4,UBE2N,RPS6KA3,TIRAP
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.00843971431428496	-4.77480681996553	92	47	0.0149396058486968	3146	8202	5599,23291,3146,257397,5604,1660,8454,4205,1147,9252,5519,5606,466,6196,8651,3551,5601,51135,4791,7314,5598,1386,5970,4214,7311,5609,7867,51295,7335,1846,10333,7316,5595,10392,23118,6233,1845,5608,4793,10454,79155,5594,5528,6416,7334,6197,114609	MAPK8,FBXW11,HMGB1,TAB3,MAP2K1,DHX9,CUL1,MEF2A,CHUK,RPS6KA5,PPP2R1B,MAP2K3,ATF1,RPS6KA2,SOCS1,IKBKB,MAPK9,IRAK4,NFKB2,UBB,MAPK7,ATF2,RELA,MAP3K1,UBA52,MAP2K7,MAPKAPK3,ECSIT,UBE2V1,DUSP4,TLR6,UBC,MAPK3,NOD1,TAB2,RPS27A,DUSP3,MAP2K6,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,MAP2K4,UBE2N,RPS6KA3,TIRAP
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	0.00879477913422863	-4.73359701375961	61	33	0.0104895104895105	3146	8202	5599,836,50650,7410,5879,7204,7531,83464,57449,8878,5664,835,9181,10018,9828,7314,6453,6655,7311,6654,51107,10276,84033,23365,11214,7316,23421,27018,6233,23385,23229,64857,2245	MAPK8,CASP3,ARHGEF3,VAV2,RAC1,TRIO,YWHAE,APH1B,PLEKHG5,SQSTM1,PSEN2,CASP2,ARHGEF2,BCL2L11,ARHGEF17,UBB,ITSN1,SOS2,UBA52,SOS1,APH1A,NET1,OBSCN,ARHGEF12,AKAP13,UBC,ITGB3BP,NGFRAP1,RPS27A,NCSTN,ARHGEF9,PLEKHG2,FGD1
R-HSA-202403	TCR signaling	0.0089586310729583	-4.71513784570357	115	57	0.0181182453909727	3146	8202	23291,5689,5693,5683,5713,5716,8454,1147,55740,5720,5715,9491,5708,7408,5696,5687,5688,3551,5062,5296,5701,23198,10213,5717,7321,7314,5970,5686,5694,5170,7311,5692,4690,5295,5702,5695,10892,7335,5710,5685,5691,7316,5704,5335,997,5719,23118,6233,5706,5709,7322,5690,5705,9861,5700,7334,5711	FBXW11,PSMB1,PSMB5,PSMA2,PSMD7,PSMD10,CUL1,CHUK,ENAH,PSME1,PSMD9,PSMF1,PSMD2,VASP,PSMB8,PSMA6,PSMA7,IKBKB,PAK2,PIK3R2,PSMC2,PSME4,PSMD14,PSMD11,UBE2D1,UBB,RELA,PSMA5,PSMB6,PDPK1,UBA52,PSMB4,NCK1,PIK3R1,PSMC3,PSMB7,MALT1,UBE2V1,PSMD4,PSMA4,PSMB3,UBC,PSMC4,PLCG1,CDC34,PSMD13,TAB2,RPS27A,PSMC6,PSMD3,UBE2D2,PSMB2,PSMC5,PSMD6,PSMC1,UBE2N,PSMD5
R-HSA-110056	MAPK3 (ERK1) activation	0.00915177473721068	-4.69380745815169	10	8	0.00254291163382072	3146	8202	3572,3569,5781,5604,3717,983,7297,5595	IL6ST,IL6,PTPN11,MAP2K1,JAK2,CDK1,TYK2,MAPK3
R-HSA-69473	G2/M DNA damage checkpoint	0.00932490541404365	-4.6750664567698	70	37	0.0117609663064209	3146	8202	51588,84142,8367,10524,1111,7531,9656,891,580,8360,7341,8365,121504,7465,8366,8364,4361,84126,8345,10971,7468,9025,672,8368,995,983,7532,8294,7158,7336,3014,51720,7534,79184,7533,7334,2810	PIAS4,FAM175A,HIST1H4E,KAT5,CHEK1,YWHAE,MDC1,CCNB1,BARD1,HIST1H4D,SUMO1,HIST1H4H,HIST4H4,WEE1,HIST1H4B,HIST1H4C,MRE11A,ATRIP,HIST1H2BH,YWHAQ,WHSC1,RNF8,BRCA1,HIST1H4L,CDC25C,CDK1,YWHAG,HIST1H4I,TP53BP1,UBE2V2,H2AFX,UIMC1,YWHAZ,BRCC3,YWHAH,UBE2N,SFN
R-HSA-1433557	Signaling by SCF-KIT	0.00949639569708628	-4.65684295267286	307	138	0.0438652256834075	3146	8202	7249,4763,5786,6777,5720,1026,5519,5906,5696,5688,5296,5701,10818,64223,7311,9978,208,842,283455,5719,6233,4296,4254,5527,2932,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,808,1111,10256,5715,1847,5686,5702,5908,8437,5605,5685,5691,5921,5704,2886,2069,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5879,5037,5604,2064,1147,4067,5687,4193,8651,6464,6711,23198,10213,1027,8503,253260,7414,2241,207,2931,5777,8452,5695,1742,1846,2260,8660,817,5529,2534,5706,5709,80824,5536,9861,4343,5594,5711,1844,23112,673,5716,79109,9491,2309,5708,117145,5781,3717,5717,2065,7314,6774,2242,6199,6709,1843,5694,5170,4303,5692,6654,3164,5295,5747,7525,5710,7316,5595,2885,57761,84078,152559,6776,84292,3265	TSC2,NF1,PTPRA,STAT5B,PSME1,CDKN1A,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,PSMD13,RPS27A,MAP3K11,KITLG,PPP2R5C,GSK3B,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,CALM3,CHEK1,CNKSR1,PSMD9,DUSP5,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,GRB7,EREG,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,RAC1,PEBP1,MAP2K1,ERBB2,CHUK,LYN,PSMA6,MDM2,SOCS1,SHC1,SPTBN1,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,VCL,FER,AKT1,GSK3A,PTPN6,CUL3,PSMB7,DLG4,DUSP4,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,PPP5C,PSMD6,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,PSMD10,MAPKAP1,PSMF1,FOXO3,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,STAT3,FES,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,PTK2,YES1,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,STAT5A,WDR83,HRAS
R-HSA-1236394	Signaling by ERBB4	0.00970856647882416	-4.63474664106656	312	140	0.0445009535918627	3146	8202	7249,4763,5786,8454,6777,5720,1026,5519,5906,5696,5688,5296,5701,5664,10818,64223,7311,9978,51107,208,83737,842,10413,283455,5719,6233,25970,4296,4254,2932,5527,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,808,10256,5715,83464,1847,5686,5702,5908,8437,5605,5685,5691,5921,5704,2069,9611,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,1147,5687,4193,6464,6711,23198,10213,1027,8503,253260,7414,207,2931,8452,5695,1742,1846,2260,8660,817,5529,2534,5706,23118,5709,80824,5536,9861,4343,5594,23385,5711,1844,23112,673,5716,79109,9491,2309,5708,117145,5781,3717,5717,11059,2065,7314,6199,6709,1843,5694,5170,6868,4303,5692,6654,3164,5295,5747,5710,7316,5595,2885,57761,84078,152559,6776,84292,3265	TSC2,NF1,PTPRA,CUL1,STAT5B,PSME1,CDKN1A,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,PSEN2,FRS2,MLST8,UBA52,RBX1,APH1A,AKT2,ITCH,CASP9,YAP1,KSR2,PSMD13,RPS27A,SH2B1,MAP3K11,KITLG,GSK3B,PPP2R5C,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,CALM3,CNKSR1,PSMD9,APH1B,DUSP5,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,EREG,NCOR1,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PSMA6,MDM2,SHC1,SPTBN1,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,VCL,AKT1,GSK3A,CUL3,PSMB7,DLG4,DUSP4,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,TAB2,PSMD3,DUSP16,PPP5C,PSMD6,MOV10,MAPK1,NCSTN,PSMD5,DUSP2,TNRC6B,BRAF,PSMD10,MAPKAP1,PSMF1,FOXO3,PSMD2,THEM4,PTPN11,JAK2,PSMD11,WWP1,ERBB3,UBB,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,ADAM17,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,STAT5A,WDR83,HRAS
R-HSA-75109	Triglyceride Biosynthesis	0.00993033263534899	-4.61216130346506	68	36	0.0114431023521933	3146	8202	9374,2710,2180,84803,10554,56894,6319,64900,64834,253558,2819,55326,117145,2182,9524,8694,79888,23171,31,6576,55856,60481,56895,79071,83401,2181,2194,9200,641371,137964,201562,84649,254531,57678,11332,10005	PPT2,GK,ACSL1,GPAT3,AGPAT1,AGPAT3,SCD,LPIN3,ELOVL1,LCLAT1,GPD1,AGPAT5,THEM4,ACSL4,TECR,DGAT1,LPCAT1,GPD1L,ACACA,SLC25A1,ACOT13,ELOVL5,AGPAT4,ELOVL6,ELOVL3,ACSL3,FASN,HACD1,ACOT1,GPAT4,HACD2,DGAT2,LPCAT4,GPAM,ACOT7,ACOT8
R-HSA-6784531	tRNA processing in the nucleus	0.0105122579277041	-4.55521328103937	55	30	0.00953591862682772	3146	8202	54913,23511,8480,10978,9631,10775,348995,79074,8021,11260,79042,9883,23165,129401,10556,7175,5903,29894,339487,57122,51493,1478,23636,9972,5901,283742,80746,116461,79902,81929	RPP25,NUP188,RAE1,CLP1,NUP155,POP4,NUP43,C2orf49,NUP214,XPOT,TSEN34,POM121,NUP205,NUP35,RPP30,TPR,RANBP2,CPSF1,ZBTB8OS,NUP107,RTCB,CSTF2,NUP62,NUP153,RAN,FAM98B,TSEN2,TSEN15,NUP85,SEH1L
R-HSA-1227986	Signaling by ERBB2	0.0106755395054879	-4.53980018198874	320	143	0.0454545454545455	3146	8202	7249,4763,5786,5720,1026,3709,5519,5906,5696,5688,10193,5296,5701,10818,5567,64223,7311,9978,208,842,283455,5335,5719,6233,4296,4254,5527,2932,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,814,808,10256,5715,1847,5581,5686,5702,5908,8437,5605,5685,5691,5921,5704,10273,2886,3708,2069,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,1147,5566,5687,4193,6464,6711,115,23198,10213,1027,8503,253260,10768,7414,207,2931,8452,5695,1742,55914,1846,3710,2260,8660,817,5529,2534,5706,5709,80824,9861,5536,4343,5594,5711,1844,23112,673,5716,79109,2309,9491,5708,117145,5781,3717,5717,2065,3320,7314,6199,6709,1843,5694,5170,4303,5692,6654,3164,5295,9101,5747,7525,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,NF1,PTPRA,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,RNF41,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,PLCG1,PSMD13,RPS27A,MAP3K11,KITLG,PPP2R5C,GSK3B,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,PRKCE,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,STUB1,GRB7,ITPR1,EREG,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,AHCYL1,VCL,AKT1,GSK3A,CUL3,PSMB7,DLG4,ERBB2IP,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,PSMD6,PPP5C,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,PSMD10,MAPKAP1,FOXO3,PSMF1,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,HSP90AA1,UBB,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,USP8,PTK2,YES1,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-5675221	Negative regulation of MAPK pathway	0.0107206779131563	-4.53558088717136	40	23	0.00731087094723458	3146	8202	1844,7311,673,5894,5037,5604,1846,1847,5605,7316,5519,5595,5529,6233,80824,5527,152559,7314,5536,5594,5528,3265,1843	DUSP2,UBA52,BRAF,RAF1,PEBP1,MAP2K1,DUSP4,DUSP5,MAP2K2,UBC,PPP2R1B,MAPK3,PPP2R5E,RPS27A,DUSP16,PPP2R5C,PAQR3,UBB,PPP5C,MAPK1,PPP2R5D,HRAS,DUSP1
R-HSA-71291	Metabolism of amino acids and derivatives	0.0107993594675994	-4.5282684551664	212	98	0.0311506675143039	3146	8202	6723,58472,5683,56922,51380,51686,5720,2639,4942,2752,587,4552,5687,440,5696,51166,6821,2806,5688,65263,5701,10213,23198,51074,1491,113451,2731,55217,2954,6303,5695,56267,1743,4953,7263,5831,2744,9380,10166,5719,5706,8942,5709,5690,5705,9861,5700,4946,5711,5723,84706,5689,5693,4329,593,84245,1734,3028,5713,435,5716,5715,9491,4507,8659,5708,883,1468,51582,5717,85007,1152,27034,5832,1629,5686,223,5694,58478,5625,1373,5692,29968,80150,594,2729,5702,262,5710,5685,5691,5704,36,4947,38,55748,125061,2653	SRM,SQRDL,PSMA2,MCCC1,CSAD,OAZ3,PSME1,GCDH,OAT,GLUL,BCAT2,MTRR,PSMA6,ASNS,PSMB8,AADAT,SUOX,GOT2,PSMA7,PYCRL,PSMC2,PSMD14,PSME4,APIP,CTH,AZIN2,GLDC,TMLHE,GSTZ1,SAT1,PSMB7,CCBL2,DLST,ODC1,TST,PYCR1,GLS,GRHPR,SLC25A15,PSMD13,PSMC6,KYNU,PSMD3,PSMB2,PSMC5,PSMD6,PSMC1,OAZ1,PSMD5,PSPH,GPT2,PSMB1,PSMB5,ALDH6A1,BCKDHA,MRI1,DIO2,HSD17B10,PSMD7,ASL,PSMD10,PSMD9,PSMF1,MTAP,ALDH4A1,PSMD2,CCBL1,SLC25A10,AZIN1,PSMD11,PHYKPL,CKB,ACAD8,ALDH18A1,DBT,PSMA5,ALDH9A1,PSMB6,ENOPH1,PRODH,CPS1,PSMB4,PSAT1,ASRGL1,BCKDHB,GCLC,PSMC3,AMD1,PSMD4,PSMA4,PSMB3,PSMC4,ACADSB,OAZ2,ACAT1,CNDP2,AFMID,GCSH
R-HSA-199220	Vitamin B5 (pantothenate) metabolism	0.011144833118174	-4.49677928595098	12	9	0.00286077558804832	3146	8202	80025,60496,79717,51248,8034,55229,53354,2194,79646	PANK2,AASDHPPT,PPCS,PDZD11,SLC25A16,PANK4,PANK1,FASN,PANK3
R-HSA-168276	NS1 Mediated Effects on Host Pathways	0.0112239500121671	-4.48970538984771	38	22	0.00699300699300699	3146	8202	23511,3841,8480,9631,348995,8021,9636,23165,129401,9883,7175,5903,5610,3840,3839,57122,23636,3838,9972,79902,3837,81929	NUP188,KPNA5,RAE1,NUP155,NUP43,NUP214,ISG15,NUP205,NUP35,POM121,TPR,RANBP2,EIF2AK2,KPNA4,KPNA3,NUP107,NUP62,KPNA2,NUP153,NUP85,KPNB1,SEH1L
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	0.0117261786872052	-4.44593144200896	36	21	0.0066751430387794	3146	8202	23511,8480,7884,10482,9631,348995,53981,8021,9883,23165,129401,7175,5903,29894,57122,23636,9972,22916,1977,79902,81929	NUP188,RAE1,SLBP,NXF1,NUP155,NUP43,CPSF2,NUP214,POM121,NUP205,NUP35,TPR,RANBP2,CPSF1,NUP107,NUP62,NUP153,NCBP2,EIF4E,NUP85,SEH1L
R-HSA-1592230	Mitochondrial biogenesis	0.0118192194477799	-4.43802830575154	51	28	0.00890019071837254	3146	8202	3054,80205,51106,7978,2551,5565,8841,6256,5465,6604,5571,4209,506,11232,2553,1387,4899,51422,23054,211,6907,6742,9611,10891,2101,5469,1386,10498	HCFC1,CHD9,TFB1M,MTERF1,GABPA,PRKAB2,HDAC3,RXRA,PPARA,SMARCD3,PRKAG1,MEF2D,ATP5B,POLG2,GABPB1,CREBBP,NRF1,PRKAG2,NCOA6,ALAS1,TBL1X,SSBP1,NCOR1,PPARGC1A,ESRRA,MED1,ATF2,CARM1
R-HSA-1280218	Adaptive Immune System	0.0120743487202177	-4.41667201711196	668	284	0.0902733630006357	3146	8202	84727,7249,8722,6890,8454,9666,55740,5720,9867,80176,5519,6786,5688,10193,8907,1785,54778,163,10818,26259,64223,7311,208,8905,842,56992,127544,5335,5719,6233,3688,4254,5527,2932,642,2549,51433,5689,9039,80196,3693,5715,811,7337,54926,83547,10112,4277,5702,5908,4591,140461,5685,5691,10425,22872,10273,160,3708,9604,685,90933,26052,5894,5879,1147,29126,5566,55182,6464,79876,10213,1027,51434,253260,6891,64219,140460,7321,5970,10484,2931,8452,8697,3710,2260,56658,8660,3796,5529,6049,2534,29927,7334,5711,1783,23112,6396,1173,2923,567,9354,2309,9491,3105,26273,5708,1075,10075,117145,5781,6047,26046,11059,89910,79659,2065,9020,7314,80329,5694,5170,6654,5295,29882,7525,5710,3832,7316,51128,10671,10427,57761,81930,997,100507436,51444,51752,93611,3685,23376,23291,81559,79654,55585,65264,3709,1026,11004,30011,64682,5696,5906,51343,5701,51529,5296,10393,51619,23295,7220,3835,140459,5567,55176,10616,9978,4690,83737,7335,1535,1213,5690,51130,5705,5528,5700,11258,7323,10120,5693,9871,26272,26118,5713,140462,3831,808,8519,9246,92912,7408,5062,8139,84876,9690,5686,10892,6921,7324,5704,996,2069,11127,7534,27338,192669,5071,5817,7317,2475,5683,55284,8655,2064,821,4067,5687,4193,8651,197131,3551,23198,8503,10768,10802,79465,207,6923,7879,5777,991,5695,118424,958,23352,9021,23118,5706,7336,5709,10477,9861,57154,4343,1175,51665,1781,9320,25831,5966,89953,79109,5716,375,3799,55070,27252,9632,51164,51465,6737,5717,130340,9730,7327,6199,5692,4303,3164,7332,6502,7328,64750,55236,2885,8453,7322,23308,4793,164,11065,3265,63891	SPSB2,TSC2,CTSF,TAP1,CUL1,DZIP3,ENAH,PSME1,PJA2,SPSB1,PPP2R1B,STIM1,PSMA7,RNF41,AP1M1,DNM2,RNF111,AP2B1,FRS2,FBXW8,MLST8,UBA52,AKT2,AP1S2,CASP9,KIF15,RNF19B,PLCG1,PSMD13,RPS27A,ITGB1,KITLG,PPP2R5C,GSK3B,BLMH,GAB1,ANAPC5,PSMB1,UBA3,RNF34,ITGB5,PSMD9,CALR,UBE3A,UBE2R2,RILP,KIF20A,MICB,PSMC3,RAP1B,TRIM37,ASB8,PSMA4,PSMB3,ARIH2,SEC31A,STUB1,AP2A1,ITPR1,RNF14,BTC,TRIM41,DNM3,RAF1,RAC1,CHUK,CD274,PRKACA,RNF220,SHC1,UBA5,PSMD14,CDKN1B,ANAPC7,RICTOR,TAP2,PJA1,ASB7,UBE2D1,RELA,SEC23A,GSK3A,CUL3,CDC23,ITPR3,FGFR1,TRIM39,IRS2,KIF2A,PPP2R5E,RNF6,FYN,SEC61A1,UBE2N,PSMD5,DYNC1LI2,TNRC6B,SEC13,AP2M1,PDIA3,B2M,UBE4A,FOXO3,PSMF1,HLA-A,FBXO3,PSMD2,CTSC,HUWE1,THEM4,PTPN11,RNF4,LTN1,WWP1,UBE3B,DYNC2H1,ERBB3,MAP3K14,UBB,ULBP1,PSMB6,PDPK1,SOS1,PIK3R1,ANAPC2,YES1,PSMD4,KIF11,UBC,SAR1B,DCTN6,SEC24B,TRIB3,KIF18A,CDC34,MICA,RNF138,ERAP1,FBXO44,ITGAV,UFL1,FBXW11,TRIM11,HECTD3,UBE2Q1,UBE2Z,ITPR2,CDKN1A,KIF2C,SH3KBP1,ANAPC1,PSMB8,RAP1A,FZR1,PSMC2,ANAPC11,PIK3R2,ANAPC10,UBE2D4,MGRN1,TRPC1,KIF22,ASB6,PRKACB,SEC61A2,RBCK1,RBX1,NCK1,ITCH,UBE2V1,CYBA,CLTC,PSMB2,ASB3,PSMC5,PPP2R5D,PSMC1,DCTN3,UBE2D3,ACTR1B,PSMB5,SEC24D,FBXO4,WSB1,PSMD7,ASB9,KLC1,CALM3,IFITM1,UBE2L6,UBE2Q2,VASP,PAK2,GAN,ORAI1,UBE3C,PSMA5,MALT1,TCEB1,UBE2E1,PSMC4,CDC27,EREG,KIF3A,YWHAZ,UBE2S,AGO3,PARK2,PVR,UBA1,MTOR,PSMA2,UBE2W,DYNLL1,ERBB2,CANX,LYN,PSMA6,MDM2,SOCS1,UBR1,IKBKB,PSME4,PIK3R3,AHCYL1,SEC24A,ULBP3,AKT1,TCEB2,RAB7A,PTPN6,CDC20,PSMB7,UBE2J2,CD40,UBR4,SOCS3,TAB2,PSMC6,UBE2V2,PSMD3,UBE2E3,PSMD6,SMURF1,MOV10,AP2S1,ASB1,DYNC1I2,TRIP12,HECTD1,REL,KLC4,MAPKAP1,PSMD10,ARF1,KIF5B,DET1,KLHL20,SEC24C,DCTN4,UBE2J1,TRIM21,PSMD11,AP1S3,VPRBP,UBE2G2,RPS6KB2,PSMB4,FOXO4,NR4A1,UBE2L3,SKP2,UBE2H,SMURF2,UBA6,GRB2,CUL2,UBE2D2,ICOSLG,NFKBIB,AP1G1,UBE2C,HRAS,RNF123
R-HSA-4791275	Signaling by WNT in cancer	0.012220387286356	-4.40464963291307	34	20	0.00635727908455181	3146	8202	79412,8322,64840,8325,139285,1488,324,1452,8658,5519,6934,22943,5529,1499,4040,2932,5527,7855,1487,5528	KREMEN2,FZD4,PORCN,FZD8,AMER1,CTBP2,APC,CSNK1A1,TNKS,PPP2R1B,TCF7L2,DKK1,PPP2R5E,CTNNB1,LRP6,GSK3B,PPP2R5C,FZD5,CTBP1,PPP2R5D
R-HSA-3371568	Attenuation phase	0.0125390141472015	-4.37891036351841	14	10	0.00317863954227591	3146	8202	3305,2033,1387,3326,3297,3320,10728,3337,3303,3304	HSPA1L,EP300,CREBBP,HSP90AB1,HSF1,HSP90AA1,PTGES3,DNAJB1,HSPA1A,HSPA1B
R-HSA-389356	CD28 co-stimulation	0.0126975080165646	-4.36634952393923	32	19	0.00603941513032422	3146	8202	5170,207,2475,208,5879,5295,79109,7525,4067,2885,57761,2534,117145,5296,5062,8503,253260,9020,64223	PDPK1,AKT1,MTOR,AKT2,RAC1,PIK3R1,MAPKAP1,YES1,LYN,GRB2,TRIB3,FYN,THEM4,PIK3R2,PAK2,PIK3R3,RICTOR,MAP3K14,MLST8
R-HSA-68962	Activation of the pre-replicative complex	0.0131458014550631	-4.33165285232318	30	18	0.00572155117609663	3146	8202	4999,4175,55388,5558,5422,10926,990,5557,8318,5427,5426,5000,8317,5001,84515,23595,4172,23594	ORC2,MCM6,MCM10,PRIM2,POLA1,DBF4,CDC6,PRIM1,CDC45,POLE2,POLE,ORC4,CDC7,ORC5,MCM8,ORC3,MCM3,ORC6
R-HSA-5684264	MAP3K8 (TPL2)-dependent MAPK1/3 activation	0.0134517317279443	-4.30864742821523	16	11	0.0034965034965035	3146	8202	23291,7311,6233,3551,5604,8454,1147,7314,79155,6416,7316	FBXW11,UBA52,RPS27A,IKBKB,MAP2K1,CUL1,CHUK,UBB,TNIP2,MAP2K4,UBC
R-HSA-162710	Synthesis of glycosylphosphatidylinositol (GPI)	0.0134517317279443	-4.30864742821523	16	11	0.0034965034965035	3146	8202	5279,8818,284098,51227,5283,54872,9488,84720,9487,5281,55650	PIGC,DPM2,PIGW,PIGP,PIGH,PIGG,PIGB,PIGO,PIGL,PIGF,PIGV
R-HSA-5625900	RHO GTPases activate CIT	0.0134517317279443	-4.30864742821523	16	11	0.0034965034965035	3146	8202	10398,387,11113,389,5879,9055,1742,1027,4637,4628,388	MYL9,RHOA,CIT,RHOC,RAC1,PRC1,DLG4,CDKN1B,MYL6,MYH10,RHOB
R-HSA-163210	Formation of ATP by chemiosmotic coupling	0.0134517317279443	-4.30864742821523	16	11	0.0034965034965035	3146	8202	516,518,27109,10476,509,521,506,498,514,9551,515	ATP5G1,ATP5G3,ATP5S,ATP5H,ATP5C1,ATP5I,ATP5B,ATP5A1,ATP5E,ATP5J2,ATP5F1
R-HSA-380972	Energy dependent regulation of mTOR by LKB1-AMPK	0.0135501031943798	-4.30136111586404	28	17	0.00540368722186904	3146	8202	7249,2475,5565,92335,5562,8649,64121,5571,6009,10542,57521,51422,389541,10325,5494,58528,64223	TSC2,MTOR,PRKAB2,STRADA,PRKAA1,LAMTOR3,RRAGC,PRKAG1,RHEB,LAMTOR5,RPTOR,PRKAG2,LAMTOR4,RRAGB,PPM1A,RRAGD,MLST8
R-HSA-1632852	Macroautophagy	0.0141110441245955	-4.26079751694694	67	35	0.0111252383979657	3146	8202	7405,7249,60673,2475,5565,8655,5562,8649,30849,64121,8408,81631,8678,55626,10542,57521,84938,11337,11152,64223,84971,22863,9821,5571,9140,25978,6009,51422,389541,10325,26100,9474,23192,58528,92421	UVRAG,TSC2,ATG101,MTOR,PRKAB2,DYNLL1,PRKAA1,LAMTOR3,PIK3R4,RRAGC,ULK1,MAP1LC3B,BECN1,AMBRA1,LAMTOR5,RPTOR,ATG4C,GABARAP,WDR45,MLST8,ATG4D,ATG14,RB1CC1,PRKAG1,ATG12,CHMP2B,RHEB,PRKAG2,LAMTOR4,RRAGB,WIPI2,ATG5,ATG4B,RRAGD,CHMP4C
R-HSA-3371571	HSF1-dependent transactivation	0.0142732760601883	-4.24936629709449	22	14	0.00445009535918627	3146	8202	57521,3305,2033,1387,817,2475,3326,3297,3320,10728,3337,3303,3304,64223	RPTOR,HSPA1L,EP300,CREBBP,CAMK2D,MTOR,HSP90AB1,HSF1,HSP90AA1,PTGES3,DNAJB1,HSPA1A,HSPA1B,MLST8
R-HSA-71336	Pentose phosphate pathway (hexose monophosphate shunt)	0.0149271136956529	-4.20457600858153	7	6	0.00190718372536554	3146	8202	6120,25796,6888,2539,22934,5226	RPE,PGLS,TALDO1,G6PD,RPIA,PGD
R-HSA-5625740	RHO GTPases activate PKNs	0.0156779377962525	-4.15550079080528	90	45	0.0143038779402416	3146	8202	10398,3015,4659,8367,389,5879,8358,8350,7531,4628,8360,23028,8365,121504,5586,8366,8364,4637,653604,8345,8331,5170,8968,8352,387,10971,8368,8357,995,7532,388,8294,3012,8334,29941,8351,3014,5500,4660,7534,8338,3020,7533,2810,8354	MYL9,H2AFZ,PPP1R12A,HIST1H4E,RHOC,RAC1,HIST1H3B,HIST1H3A,YWHAE,MYH10,HIST1H4D,KDM1A,HIST1H4H,HIST4H4,PKN2,HIST1H4B,HIST1H4C,MYL6,HIST2H3D,HIST1H2BH,HIST1H2AJ,PDPK1,HIST1H3F,HIST1H3C,RHOA,YWHAQ,HIST1H4L,HIST1H3H,CDC25C,YWHAG,RHOB,HIST1H4I,HIST1H2AE,HIST1H2AC,PKN3,HIST1H3D,H2AFX,PPP1CB,PPP1R12B,YWHAZ,HIST2H2AC,H3F3A,YWHAH,SFN,HIST1H3I
R-HSA-5693607	Processing of DNA double-strand break ends	0.0161556940584578	-4.1254827181737	97	48	0.0152574698029243	3146	8202	51588,84142,5883,63967,8367,10524,1111,9656,641,580,80010,8360,7341,8365,121504,890,8366,8364,1763,6047,84126,4361,8345,7314,5984,5810,7311,5983,11073,51548,5531,7468,672,9025,8368,5982,7316,83695,8294,9156,7336,7158,6233,3014,51720,79184,7334,151987	PIAS4,FAM175A,RAD9A,CLSPN,HIST1H4E,KAT5,CHEK1,MDC1,BLM,BARD1,RMI1,HIST1H4D,SUMO1,HIST1H4H,HIST4H4,CCNA2,HIST1H4B,HIST1H4C,DNA2,RNF4,ATRIP,MRE11A,HIST1H2BH,UBB,RFC4,RAD1,UBA52,RFC3,TOPBP1,SIRT6,PPP4C,WHSC1,BRCA1,RNF8,HIST1H4L,RFC2,UBC,RHNO1,HIST1H4I,EXO1,UBE2V2,TP53BP1,RPS27A,H2AFX,UIMC1,BRCC3,UBE2N,PPP4R2
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	0.0171482899936884	-4.06585681916428	61	32	0.0101716465352829	3146	8202	10163,8936,71,5879,10096,7410,10093,4641,25,55845,63916,10092,51517,3320,10097,147179,23191,10152,4690,4651,3326,5747,10552,10458,5595,2885,1398,3984,8976,60,10109,5594	WASF2,WASF1,ACTG1,RAC1,ACTR3,VAV2,ARPC4,MYO1C,ABL1,BRK1,ELMO2,ARPC5,NCKIPSD,HSP90AA1,ACTR2,WIPF2,CYFIP1,ABI2,NCK1,MYO10,HSP90AB1,PTK2,ARPC1A,BAIAP2,MAPK3,GRB2,CRK,LIMK1,WASL,ACTB,ARPC2,MAPK1
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	0.0183848800350731	-3.99622668940259	35	20	0.00635727908455181	3146	8202	23511,8480,10482,9631,348995,53981,8021,9883,23165,129401,7175,5903,29894,57122,23636,22916,9972,1977,79902,81929	NUP188,RAE1,NXF1,NUP155,NUP43,CPSF2,NUP214,POM121,NUP205,NUP35,TPR,RANBP2,CPSF1,NUP107,NUP62,NCBP2,NUP153,EIF4E,NUP85,SEH1L
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	0.0185451320675043	-3.9875479466044	68	35	0.0111252383979657	3146	8202	10808,23511,8480,3297,3337,348995,7531,9532,3303,9883,23165,129401,51182,10049,57122,9972,6782,79902,81929,9529,23411,57805,9631,8021,5595,3304,3305,7175,5903,3308,2932,23636,22824,5594,573	HSPH1,NUP188,RAE1,HSF1,DNAJB1,NUP43,YWHAE,BAG2,HSPA1A,POM121,NUP205,NUP35,HSPA14,DNAJB6,NUP107,NUP153,HSPA13,NUP85,SEH1L,BAG5,SIRT1,CCAR2,NUP155,NUP214,MAPK3,HSPA1B,HSPA1L,TPR,RANBP2,HSPA4,GSK3B,NUP62,HSPA4L,MAPK1,BAG1
R-HSA-3214842	HDMs demethylate histones	0.0185548618779763	-3.98702342842203	48	26	0.00826446280991736	3146	8202	8352,8968,7403,8367,5927,23133,84159,8358,8350,8368,8357,55818,8360,23028,8365,121504,8294,22992,23030,8366,8364,8351,653604,5253,8242,8354	HIST1H3C,HIST1H3F,KDM6A,HIST1H4E,KDM5A,PHF8,ARID5B,HIST1H3B,HIST1H3A,HIST1H4L,HIST1H3H,KDM3A,HIST1H4D,KDM1A,HIST1H4H,HIST4H4,HIST1H4I,KDM2A,KDM4B,HIST1H4B,HIST1H4C,HIST1H3D,HIST2H3D,PHF2,KDM5C,HIST1H3I
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	0.0193242986800156	-3.94639197598138	33	19	0.00603941513032422	3146	8202	23511,8480,7884,10482,9631,348995,8021,9883,23165,129401,7175,5903,57122,23636,9972,22916,1977,79902,81929	NUP188,RAE1,SLBP,NXF1,NUP155,NUP43,NUP214,POM121,NUP205,NUP35,TPR,RANBP2,NUP107,NUP62,NUP153,NCBP2,EIF4E,NUP85,SEH1L
R-HSA-1362409	Mitochondrial iron-sulfur cluster biogenesis	0.0194334060935567	-3.94076173020698	9	7	0.00222504767959313	3146	8202	81894,23479,57128,112812,9054,2232,2230	SLC25A28,ISCU,LYRM4,FDX1L,NFS1,FDXR,FDX1
R-HSA-112411	MAPK1 (ERK2) activation	0.0194334060935567	-3.94076173020698	9	7	0.00222504767959313	3146	8202	3717,5594,7297,5605,3572,3569,5781	JAK2,MAPK1,TYK2,MAP2K2,IL6ST,IL6,PTPN11
R-HSA-5693606	DNA Double Strand Break Response	0.0196355658901091	-3.93041277088827	75	38	0.0120788302606484	3146	8202	51588,5599,84142,8367,322,10524,9656,580,8360,7341,8365,121504,25,8366,8364,4361,8345,7314,7311,2140,7468,9025,672,8368,7316,8294,23030,7336,7158,6233,3014,51720,9031,3838,5536,8467,79184,7334	PIAS4,MAPK8,FAM175A,HIST1H4E,APBB1,KAT5,MDC1,BARD1,HIST1H4D,SUMO1,HIST1H4H,HIST4H4,ABL1,HIST1H4B,HIST1H4C,MRE11A,HIST1H2BH,UBB,UBA52,EYA3,WHSC1,RNF8,BRCA1,HIST1H4L,UBC,HIST1H4I,KDM4B,UBE2V2,TP53BP1,RPS27A,H2AFX,UIMC1,BAZ1B,KPNA2,PPP5C,SMARCA5,BRCC3,UBE2N
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.0202699616220716	-3.8986152118564	31	18	0.00572155117609663	3146	8202	139285,23401,324,1857,857,2535,1452,5519,5529,1499,10023,5527,2932,4040,7855,5528,1856,8321	AMER1,FRAT2,APC,DVL3,CAV1,FZD2,CSNK1A1,PPP2R1B,PPP2R5E,CTNNB1,FRAT1,PPP2R5C,GSK3B,LRP6,FZD5,PPP2R5D,DVL2,FZD1
R-HSA-73772	RNA Polymerase I Promoter Escape	0.0202699616220716	-3.8986152118564	31	18	0.00572155117609663	3146	8202	5441,79101,5440,6908,2071,404672,221830,7343,4331,54700,9014,10849,5434,2068,84172,9533,30834,64425	POLR2L,TAF1D,POLR2K,TBP,ERCC3,GTF2H5,TWISTNB,UBTF,MNAT1,RRN3,TAF1B,CD3EAP,POLR2E,ERCC2,POLR1B,POLR1C,ZNRD1,POLR1E
R-HSA-180746	Nuclear import of Rev protein	0.0202699616220716	-3.8986152118564	31	18	0.00572155117609663	3146	8202	23511,8480,9631,348995,8021,23165,129401,9883,7175,5903,1104,57122,9972,23636,5901,79902,3837,81929	NUP188,RAE1,NUP155,NUP43,NUP214,NUP205,NUP35,POM121,TPR,RANBP2,RCC1,NUP107,NUP153,NUP62,RAN,NUP85,KPNB1,SEH1L
R-HSA-449147	Signaling by Interleukins	0.0209471370976083	-3.86575329600412	311	137	0.0435473617291799	3146	8202	23291,4763,5786,8454,3606,6777,5720,5519,5906,5696,5688,3572,5296,51135,5701,3556,10818,7311,9978,283455,7335,1398,5719,6233,4296,4254,2185,5690,5527,5705,409,5528,5700,5689,3636,5693,5245,8649,5713,808,10256,5715,1847,8878,5686,5702,8437,5908,5685,5605,5691,5921,5704,2069,7534,6416,161742,200734,685,10142,9462,5683,5894,8826,5037,5604,2064,1147,4067,5566,1399,5687,6464,6711,3551,10213,23198,8503,4791,5970,7414,4215,5777,8452,5695,1742,1846,7297,2260,9021,8660,817,5529,2534,5706,23118,80824,5709,5536,9861,10454,79155,5594,7334,5711,1844,673,257397,5716,9491,5708,5781,3717,5717,2065,7314,6774,1843,6709,5694,5692,6654,5295,7525,5747,5710,7316,5595,2885,10392,5608,3569,84078,152559,6776,84292,3265	FBXW11,NF1,PTPRA,CUL1,IL18,STAT5B,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA7,IL6ST,PIK3R2,IRAK4,PSMC2,IL1RAP,FRS2,UBA52,RBX1,KSR2,UBE2V1,CRK,PSMD13,RPS27A,MAP3K11,KITLG,PTK2B,PSMB2,PPP2R5C,PSMC5,ARRB2,PPP2R5D,PSMC1,PSMB1,INPPL1,PSMB5,PHB,LAMTOR3,PSMD7,CALM3,CNKSR1,PSMD9,DUSP5,SQSTM1,PSMA5,PSMC3,RASAL1,RAP1B,PSMA4,MAP2K2,PSMB3,RASA1,PSMC4,EREG,YWHAZ,MAP2K4,SPRED1,SPRED2,BTC,AKAP9,RASAL2,PSMA2,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,LYN,PRKACA,CRKL,PSMA6,SHC1,SPTBN1,IKBKB,PSMD14,PSME4,PIK3R3,NFKB2,RELA,VCL,MAP3K3,PTPN6,CUL3,PSMB7,DLG4,DUSP4,TYK2,FGFR1,SOCS3,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,TAB2,DUSP16,PSMD3,PPP5C,PSMD6,TAB1,TNIP2,MAPK1,UBE2N,PSMD5,DUSP2,BRAF,TAB3,PSMD10,PSMF1,PSMD2,PTPN11,JAK2,PSMD11,ERBB3,UBB,STAT3,DUSP1,SPTAN1,PSMB6,PSMB4,SOS1,PIK3R1,YES1,PTK2,PSMD4,UBC,MAPK3,GRB2,NOD1,MAP2K6,IL6,KBTBD7,PAQR3,STAT5A,WDR83,HRAS
R-HSA-5696395	Formation of Incision Complex in GG-NER	0.0209846571680407	-3.86396371933071	44	24	0.00762873490146217	3146	8202	1643,2067,7311,7508,9978,2071,8450,2072,404672,7316,7341,5886,10401,85015,4331,7336,6233,5887,54778,2073,2068,7314,7334,1642	DDB2,ERCC1,UBA52,XPC,RBX1,ERCC3,CUL4B,ERCC4,GTF2H5,UBC,SUMO1,RAD23A,PIAS3,USP45,MNAT1,UBE2V2,RPS27A,RAD23B,RNF111,ERCC5,ERCC2,UBB,UBE2N,DDB1
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	0.0212084655599362	-3.85335485814582	29	17	0.00540368722186904	3146	8202	23511,8480,9631,348995,8021,23165,129401,9883,5903,7175,7514,57122,9972,23636,5901,79902,81929	NUP188,RAE1,NUP155,NUP43,NUP214,NUP205,NUP35,POM121,RANBP2,TPR,XPO1,NUP107,NUP153,NUP62,RAN,NUP85,SEH1L
R-HSA-204626	Hypusine synthesis from eIF5A-lysine	0.0216194664040977	-3.83416114773718	4	4	0.00127145581691036	3146	8202	83475,1984,1725,56648	DOHH,EIF5A,DHPS,EIF5A2
R-HSA-165158	Activation of AKT2	0.0216194664040977	-3.83416114773718	4	4	0.00127145581691036	3146	8202	5170,57761,208,117145	PDPK1,TRIB3,AKT2,THEM4
R-HSA-73817	Purine ribonucleoside monophosphate biosynthesis	0.0222841155688213	-3.80388116065764	11	8	0.00254291163382072	3146	8202	5471,10606,471,3614,158,8833,3615,122622	PPAT,PAICS,ATIC,IMPDH1,ADSL,GMPS,IMPDH2,ADSSL1
R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.0222841155688213	-3.80388116065764	11	8	0.00254291163382072	3146	8202	9126,10274,23063,113130,8243,10735,157570,23244	SMC3,STAG1,WAPL,CDCA5,SMC1A,STAG2,ESCO2,PDS5A
R-HSA-77588	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	0.0222841155688213	-3.80388116065764	11	8	0.00254291163382072	3146	8202	25888,134353,6636,7884,22916,6637,6635,84967	ZNF473,LSM11,SNRPF,SLBP,NCBP2,SNRPG,SNRPE,LSM10
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.0223052607546968	-3.80293272005568	42	23	0.00731087094723458	3146	8202	5883,5984,5983,5810,11073,10635,10524,1111,672,641,5982,580,80010,83695,9156,5889,79728,5888,7516,1763,84126,4361,7517	RAD9A,RFC4,RFC3,RAD1,TOPBP1,RAD51AP1,KAT5,CHEK1,BRCA1,BLM,RFC2,BARD1,RMI1,RHNO1,EXO1,RAD51C,PALB2,RAD51,XRCC2,DNA2,ATRIP,MRE11A,XRCC3
R-HSA-177929	Signaling by EGFR	0.0223229170716663	-3.80214145683362	336	147	0.0467260012714558	3146	8202	7249,102,4763,5786,5720,1026,3709,5519,30011,5906,5696,5688,5296,5701,163,10818,5567,64223,7311,9978,208,842,283455,5335,5719,6233,4296,4254,5527,2932,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,29924,814,808,10256,5715,1847,5581,5686,58513,5702,5908,8437,5605,5685,5691,5921,5704,160,3708,2069,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,1147,5566,5687,4193,6464,6711,115,23198,10213,1027,8503,253260,10768,7414,207,2931,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,5709,80824,9861,5536,4343,5594,1175,5711,10252,1844,23112,1173,673,5716,79109,2309,9491,5708,117145,5781,3717,5717,2065,7314,10253,6199,6709,1843,5694,5170,6868,4303,5692,6654,3164,5295,5747,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,ADAM10,NF1,PTPRA,PSME1,CDKN1A,ITPR2,PPP2R1B,SH3KBP1,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,AP2B1,FRS2,PRKACB,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,PLCG1,PSMD13,RPS27A,MAP3K11,KITLG,PPP2R5C,GSK3B,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,EPN1,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,PRKCE,PSMA5,EPS15L1,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,AP2A1,ITPR1,EREG,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,AHCYL1,VCL,AKT1,GSK3A,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,PSMD6,PPP5C,MOV10,MAPK1,AP2S1,PSMD5,SPRY1,DUSP2,TNRC6B,AP2M1,BRAF,PSMD10,MAPKAP1,FOXO3,PSMF1,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,SPRY2,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,ADAM17,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-114452	Activation of BH3-only proteins	0.022983888971657	-3.77296178799655	25	15	0.00476795931341386	3146	8202	5599,207,5366,208,8655,7027,5534,10971,7534,5533,7531,10018,7533,2810,7532	MAPK8,AKT1,PMAIP1,AKT2,DYNLL1,TFDP1,PPP3R1,YWHAQ,YWHAZ,PPP3CC,YWHAE,BCL2L11,YWHAH,SFN,YWHAG
R-HSA-982772	Growth hormone receptor signaling	0.022983888971657	-3.77296178799655	25	15	0.00476795931341386	3146	8202	8660,1154,6868,8651,5777,8835,25970,3717,6777,6776,4067,5594,6774,5595,9021	IRS2,CISH,ADAM17,SOCS1,PTPN6,SOCS2,SH2B1,JAK2,STAT5B,STAT5A,LYN,MAPK1,STAT3,MAPK3,SOCS3
R-HSA-5578749	Transcriptional regulation by small RNAs	0.0232140468258357	-3.76299771689999	101	49	0.0155753337571519	3146	8202	3015,23511,5440,8367,8480,8358,8350,348995,8360,9883,23165,129401,8365,121504,8366,8364,57122,653604,9972,8345,5901,79902,8331,81929,8968,8352,5438,5441,5436,10526,5433,9631,8368,8357,8021,5430,5432,8294,7175,5903,3012,8334,8351,5434,3014,23636,8338,3020,8354	H2AFZ,NUP188,POLR2K,HIST1H4E,RAE1,HIST1H3B,HIST1H3A,NUP43,HIST1H4D,POM121,NUP205,NUP35,HIST1H4H,HIST4H4,HIST1H4B,HIST1H4C,NUP107,HIST2H3D,NUP153,HIST1H2BH,RAN,NUP85,HIST1H2AJ,SEH1L,HIST1H3F,HIST1H3C,POLR2I,POLR2L,POLR2G,IPO8,POLR2D,NUP155,HIST1H4L,HIST1H3H,NUP214,POLR2A,POLR2C,HIST1H4I,TPR,RANBP2,HIST1H2AE,HIST1H2AC,HIST1H3D,POLR2E,H2AFX,NUP62,HIST2H2AC,H3F3A,HIST1H3I
R-HSA-168253	Host Interactions with Influenza Factors	0.0236988672182831	-3.74232802868026	40	22	0.00699300699300699	3146	8202	23511,3841,8480,9631,348995,8021,9636,23165,129401,9883,7175,5903,5610,3840,3839,57122,23636,3838,9972,79902,3837,81929	NUP188,KPNA5,RAE1,NUP155,NUP43,NUP214,ISG15,NUP205,NUP35,POM121,TPR,RANBP2,EIF2AK2,KPNA4,KPNA3,NUP107,NUP62,KPNA2,NUP153,NUP85,KPNB1,SEH1L
R-HSA-203927	MicroRNA (miRNA) biogenesis	0.0237615802624786	-3.73968527733577	23	14	0.00445009535918627	3146	8202	5432,5438,5436,5441,54487,5440,23405,5434,6895,5433,5901,8575,192669,5430	POLR2C,POLR2I,POLR2G,POLR2L,DGCR8,POLR2K,DICER1,POLR2E,TARBP2,POLR2D,RAN,PRKRA,AGO3,POLR2A
R-HSA-175474	Assembly Of The HIV Virion	0.023948887452248	-3.73183340913746	13	9	0.00286077558804832	3146	8202	7311,6233,5045,7251,7314,55048,7316,9397,5478	UBA52,RPS27A,FURIN,TSG101,UBB,VPS37C,UBC,NMT2,PPIA
R-HSA-164938	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	0.0244077529686703	-3.71285445253548	21	13	0.00413223140495868	3146	8202	1173,160,8905,8907,163,55690,567,375,130340,51606,164,1175,3105	AP2M1,AP2A1,AP1S2,AP1M1,AP2B1,PACS1,B2M,ARF1,AP1S3,ATP6V1H,AP1G1,AP2S1,HLA-A
R-HSA-5654716	Downstream signaling of activated FGFR4	0.0246895753674485	-3.7013741743372	310	136	0.0432294977749523	3146	8202	7249,4763,5786,5720,1026,3709,5519,5906,5696,5688,5296,5701,10818,5567,64223,7311,9978,208,842,283455,5335,5719,6233,4296,4254,5527,2932,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,814,808,10256,5715,1847,5581,5686,5702,5908,8437,5605,5685,5691,5921,5704,3708,2069,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,1147,5566,5687,4193,6464,6711,115,23198,10213,1027,8503,253260,10768,7414,207,2931,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,5709,80824,9861,5536,4343,5594,5711,1844,23112,673,5716,79109,9491,2309,5708,117145,5781,3717,5717,2065,7314,6199,6709,1843,5694,5170,4303,5692,6654,3164,5295,5747,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,NF1,PTPRA,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,PLCG1,PSMD13,RPS27A,MAP3K11,KITLG,PPP2R5C,GSK3B,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,PRKCE,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,ITPR1,EREG,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,AHCYL1,VCL,AKT1,GSK3A,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,PSMD6,PPP5C,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,PSMD10,MAPKAP1,PSMF1,FOXO3,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-5654687	Downstream signaling of activated FGFR1	0.0246895753674485	-3.7013741743372	310	136	0.0432294977749523	3146	8202	7249,4763,5786,5720,1026,3709,5519,5906,5696,5688,5296,5701,10818,5567,64223,7311,9978,208,842,283455,5335,5719,6233,4296,4254,5527,2932,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,814,808,10256,5715,1847,5581,5686,5702,5908,8437,5605,5685,5691,5921,5704,3708,2069,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,1147,5566,5687,4193,6464,6711,115,23198,10213,1027,8503,253260,10768,7414,207,2931,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,5709,80824,9861,5536,4343,5594,5711,1844,23112,673,5716,79109,9491,2309,5708,117145,5781,3717,5717,2065,7314,6199,6709,1843,5694,5170,4303,5692,6654,3164,5295,5747,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,NF1,PTPRA,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,PLCG1,PSMD13,RPS27A,MAP3K11,KITLG,PPP2R5C,GSK3B,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,PRKCE,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,ITPR1,EREG,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,AHCYL1,VCL,AKT1,GSK3A,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,PSMD6,PPP5C,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,PSMD10,MAPKAP1,PSMF1,FOXO3,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-5654708	Downstream signaling of activated FGFR3	0.0246895753674485	-3.7013741743372	310	136	0.0432294977749523	3146	8202	7249,4763,5786,5720,1026,3709,5519,5906,5696,5688,5296,5701,10818,5567,64223,7311,9978,208,842,283455,5335,5719,6233,4296,4254,5527,2932,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,814,808,10256,5715,1847,5581,5686,5702,5908,8437,5605,5685,5691,5921,5704,3708,2069,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,1147,5566,5687,4193,6464,6711,115,23198,10213,1027,8503,253260,10768,7414,207,2931,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,5709,80824,9861,5536,4343,5594,5711,1844,23112,673,5716,79109,9491,2309,5708,117145,5781,3717,5717,2065,7314,6199,6709,1843,5694,5170,4303,5692,6654,3164,5295,5747,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,NF1,PTPRA,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,PLCG1,PSMD13,RPS27A,MAP3K11,KITLG,PPP2R5C,GSK3B,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,PRKCE,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,ITPR1,EREG,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,AHCYL1,VCL,AKT1,GSK3A,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,PSMD6,PPP5C,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,PSMD10,MAPKAP1,PSMF1,FOXO3,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-5654696	Downstream signaling of activated FGFR2	0.0246895753674485	-3.7013741743372	310	136	0.0432294977749523	3146	8202	7249,4763,5786,5720,1026,3709,5519,5906,5696,5688,5296,5701,10818,5567,64223,7311,9978,208,842,283455,5335,5719,6233,4296,4254,5527,2932,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,814,808,10256,5715,1847,5581,5686,5702,5908,8437,5605,5685,5691,5921,5704,3708,2069,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,1147,5566,5687,4193,6464,6711,115,23198,10213,1027,8503,253260,10768,7414,207,2931,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,5709,80824,9861,5536,4343,5594,5711,1844,23112,673,5716,79109,9491,2309,5708,117145,5781,3717,5717,2065,7314,6199,6709,1843,5694,5170,4303,5692,6654,3164,5295,5747,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,NF1,PTPRA,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,PLCG1,PSMD13,RPS27A,MAP3K11,KITLG,PPP2R5C,GSK3B,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,PRKCE,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,ITPR1,EREG,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,AHCYL1,VCL,AKT1,GSK3A,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,PSMD6,PPP5C,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,PSMD10,MAPKAP1,PSMF1,FOXO3,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-111447	Activation of BAD and translocation to mitochondria	0.0247788484363192	-3.69776487535737	15	10	0.00317863954227591	3146	8202	207,208,5534,10971,7534,5533,7531,7533,7532,2810	AKT1,AKT2,PPP3R1,YWHAQ,YWHAZ,PPP3CC,YWHAE,YWHAH,YWHAG,SFN
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.0248580539721376	-3.69457347544315	19	12	0.00381436745073109	3146	8202	2885,5335,7311,6464,6654,6233,5295,3320,7314,3265,2549,7316	GRB2,PLCG1,UBA52,SHC1,SOS1,RPS27A,PIK3R1,HSP90AA1,UBB,HRAS,GAB1,UBC
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	0.0248580539721376	-3.69457347544315	19	12	0.00381436745073109	3146	8202	5984,5111,5983,5426,328,5427,3978,5981,10714,5424,5982,5425	RFC4,PCNA,RFC3,POLE,APEX1,POLE2,LIG1,RFC1,POLD3,POLD1,RFC2,POLD2
R-HSA-71403	Citric acid cycle (TCA cycle)	0.0248580539721376	-3.69457347544315	19	12	0.00381436745073109	3146	8202	50,8802,6391,4191,3419,23530,1431,8801,3418,3420,1743,6392	ACO2,SUCLG1,SDHC,MDH2,IDH3A,NNT,CS,SUCLG2,IDH2,IDH3B,DLST,SDHD
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.0248580539721376	-3.69457347544315	19	12	0.00381436745073109	3146	8202	2885,5335,7311,6464,6654,6233,5295,3320,7314,3265,2549,7316	GRB2,PLCG1,UBA52,SHC1,SOS1,RPS27A,PIK3R1,HSP90AA1,UBB,HRAS,GAB1,UBC
R-HSA-1643713	Signaling by EGFR in Cancer	0.0248580539721376	-3.69457347544315	19	12	0.00381436745073109	3146	8202	2885,5335,7311,6464,6654,6233,5295,3320,7314,3265,2549,7316	GRB2,PLCG1,UBA52,SHC1,SOS1,RPS27A,PIK3R1,HSP90AA1,UBB,HRAS,GAB1,UBC
R-HSA-196299	Beta-catenin phosphorylation cascade	0.0250233053084756	-3.68794767601499	17	11	0.0034965034965035	3146	8202	5529,1499,10023,139285,2932,5527,23401,324,1452,5528,5519	PPP2R5E,CTNNB1,FRAT1,AMER1,GSK3B,PPP2R5C,FRAT2,APC,CSNK1A1,PPP2R5D,PPP2R1B
R-HSA-450604	KSRP (KHSRP) binds and destabilizes mRNA	0.0250233053084756	-3.68794767601499	17	11	0.0034965034965035	3146	8202	23404,118460,23016,207,51010,56915,8570,5393,7534,54512,5073	EXOSC2,EXOSC6,EXOSC7,AKT1,EXOSC3,EXOSC5,KHSRP,EXOSC9,YWHAZ,EXOSC4,PARN
R-HSA-5654741	Signaling by FGFR3	0.0262662639975693	-3.6394699009457	313	137	0.0435473617291799	3146	8202	7249,4763,5786,5720,1026,3709,5519,5906,5696,5688,5296,5701,10818,5567,64223,7311,9978,208,842,283455,5335,5719,6233,4296,4254,5527,2932,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,814,808,10256,5715,1847,5581,5686,5702,5908,8437,5605,5685,5691,5921,5704,3708,2069,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,1147,5566,5687,4193,6464,6711,115,23198,10213,1027,8503,253260,10768,7414,207,2931,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,5709,80824,9861,5536,4343,5594,5711,1844,23112,673,5716,79109,9491,2309,5708,117145,5781,3717,5717,2065,7314,10253,6199,6709,1843,5694,5170,4303,5692,6654,3164,5295,5747,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,NF1,PTPRA,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,PLCG1,PSMD13,RPS27A,MAP3K11,KITLG,PPP2R5C,GSK3B,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,PRKCE,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,ITPR1,EREG,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,AHCYL1,VCL,AKT1,GSK3A,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,PSMD6,PPP5C,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,PSMD10,MAPKAP1,PSMF1,FOXO3,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,SPRY2,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-5654743	Signaling by FGFR4	0.0262662639975693	-3.6394699009457	313	137	0.0435473617291799	3146	8202	7249,4763,5786,5720,1026,3709,5519,5906,5696,5688,5296,5701,10818,5567,64223,7311,9978,208,842,283455,5335,5719,6233,4296,4254,5527,2932,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,814,808,10256,5715,1847,5581,5686,5702,5908,8437,5605,5685,5691,5921,5704,3708,2069,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,1147,5566,5687,4193,6464,6711,115,23198,10213,1027,8503,253260,10768,7414,207,2931,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,5709,80824,9861,5536,4343,5594,5711,1844,23112,673,5716,79109,9491,2309,5708,117145,5781,3717,5717,2065,7314,10253,6199,6709,1843,5694,5170,4303,5692,6654,3164,5295,5747,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,NF1,PTPRA,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,PLCG1,PSMD13,RPS27A,MAP3K11,KITLG,PPP2R5C,GSK3B,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,PRKCE,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,ITPR1,EREG,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,AHCYL1,VCL,AKT1,GSK3A,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,PSMD6,PPP5C,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,PSMD10,MAPKAP1,PSMF1,FOXO3,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,SPRY2,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	0.0267868840618053	-3.61984291193983	74	37	0.0117609663064209	3146	8202	51588,5599,84142,8367,322,10524,9656,580,8360,7341,8365,121504,25,8366,8364,4361,8345,7314,7311,2140,7468,9025,672,8368,7316,8294,23030,7336,6233,7158,3014,51720,9031,5536,8467,79184,7334	PIAS4,MAPK8,FAM175A,HIST1H4E,APBB1,KAT5,MDC1,BARD1,HIST1H4D,SUMO1,HIST1H4H,HIST4H4,ABL1,HIST1H4B,HIST1H4C,MRE11A,HIST1H2BH,UBB,UBA52,EYA3,WHSC1,RNF8,BRCA1,HIST1H4L,UBC,HIST1H4I,KDM4B,UBE2V2,RPS27A,TP53BP1,H2AFX,UIMC1,BAZ1B,PPP5C,SMARCA5,BRCC3,UBE2N
R-HSA-948021	Transport to the Golgi and subsequent modification	0.0282988808086349	-3.56493302251302	95	46	0.0146217418944692	3146	8202	6396,7109,9871,6480,10905,26984,10652,8702,9919,9117,966,6484,4245,1075,9632,81562,81876,10342,3998,22870,6811,10113,10802,10484,83696,23256,7039,375056,10282,1294,5861,122553,51693,4122,10427,51128,2517,22872,27095,63908,4253,9554,55291,8775,79090,8704	SEC13,TRAPPC10,SEC24D,ST6GAL1,MAN1A2,SEC22A,YKT6,B4GALT4,SEC16A,SEC22C,CD59,ST3GAL4,MGAT1,CTSC,SEC24C,LMAN2L,RAB1B,TFG,LMAN1,PPP6R1,STX5,PREB,SEC24A,SEC23A,TRAPPC9,SCFD1,TGFA,MIA3,BET1,COL7A1,RAB1A,TRAPPC6B,TRAPPC2L,MAN2A2,SEC24B,SAR1B,FUCA1,SEC31A,TRAPPC3,NAPB,CTAGE5,SEC22B,PPP6R3,NAPA,TRAPPC6A,B4GALT2
R-HSA-5654736	Signaling by FGFR1	0.0293096294470131	-3.52983916688401	314	137	0.0435473617291799	3146	8202	7249,4763,5786,5720,1026,3709,5519,5906,5696,5688,5296,5701,10818,5567,64223,7311,9978,208,842,283455,5335,5719,6233,4296,4254,5527,2932,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,814,808,10256,5715,1847,5581,5686,5702,5908,8437,5605,5685,5691,5921,5704,3708,2069,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,1147,5566,5687,4193,6464,6711,115,23198,10213,1027,8503,253260,10768,7414,207,2931,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,5709,80824,9861,5536,4343,5594,5711,1844,23112,673,5716,79109,9491,2309,5708,117145,5781,3717,5717,2065,7314,10253,6199,6709,1843,5694,5170,4303,5692,6654,3164,5295,5747,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,NF1,PTPRA,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,PLCG1,PSMD13,RPS27A,MAP3K11,KITLG,PPP2R5C,GSK3B,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,PRKCE,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,ITPR1,EREG,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,AHCYL1,VCL,AKT1,GSK3A,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,PSMD6,PPP5C,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,PSMD10,MAPKAP1,PSMF1,FOXO3,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,SPRY2,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-73863	RNA Polymerase I Transcription Termination	0.0300059734005634	-3.5063588037883	32	18	0.00572155117609663	3146	8202	5441,79101,5440,6908,2071,404672,7270,221830,7343,4331,9014,10849,5434,2068,84172,9533,30834,64425	POLR2L,TAF1D,POLR2K,TBP,ERCC3,GTF2H5,TTF1,TWISTNB,UBTF,MNAT1,TAF1B,CD3EAP,POLR2E,ERCC2,POLR1B,POLR1C,ZNRD1,POLR1E
R-HSA-159227	Transport of the SLBP independent Mature mRNA	0.0300059734005634	-3.5063588037883	32	18	0.00572155117609663	3146	8202	23511,8480,10482,9631,348995,8021,9883,23165,129401,7175,5903,57122,22916,9972,23636,1977,79902,81929	NUP188,RAE1,NXF1,NUP155,NUP43,NUP214,POM121,NUP205,NUP35,TPR,RANBP2,NUP107,NCBP2,NUP153,NUP62,EIF4E,NUP85,SEH1L
R-HSA-5683057	MAPK family signaling cascades	0.0313034251647484	-3.46402775723942	273	120	0.0381436745073109	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5879,5604,2064,5720,5566,5519,5906,5696,5687,6464,8555,3572,5688,6711,5701,10213,23198,7414,2118,10818,5567,7311,9978,5695,8452,8550,1742,283455,1846,7297,983,2260,8660,5529,817,2534,7514,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,4343,5700,5528,5711,23112,1844,5689,5693,673,5245,8649,5713,808,5716,10256,3337,5715,2309,9491,1847,5708,5062,896,5781,3717,5717,2065,7314,5686,5694,1843,6709,5692,6654,5702,5908,8437,5747,989,5710,5605,5685,5691,7316,5921,5595,5704,2885,8202,3569,5597,84078,2069,152559,84292,8556,3265,192669	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,RAC1,MAP2K1,ERBB2,PSME1,PRKACA,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,CDC14B,IL6ST,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,ETV4,FRS2,PRKACB,UBA52,RBX1,PSMB7,CUL3,MAPKAPK5,DLG4,KSR2,DUSP4,TYK2,CDK1,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,XPO1,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,MOV10,PSMC1,PPP2R5D,PSMD5,TNRC6B,DUSP2,PSMB1,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,DNAJB1,PSMD9,FOXO3,PSMF1,DUSP5,PSMD2,PAK2,CCND3,PTPN11,JAK2,PSMD11,ERBB3,UBB,PSMA5,PSMB6,DUSP1,SPTAN1,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,SEPT7,PSMD4,MAP2K2,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,NCOA3,IL6,MAPK6,KBTBD7,EREG,PAQR3,WDR83,CDC14A,HRAS,AGO3
R-HSA-72086	mRNA Capping	0.0317519493890848	-3.44980115744681	30	17	0.00540368722186904	3146	8202	5438,5436,5441,5440,8731,2071,5433,404672,6829,5430,2962,5432,4331,5434,2963,22916,2068	POLR2I,POLR2G,POLR2L,POLR2K,RNMT,ERCC3,POLR2D,GTF2H5,SUPT5H,POLR2A,GTF2F1,POLR2C,MNAT1,POLR2E,GTF2F2,NCBP2,ERCC2
R-HSA-597592	Post-translational protein modification	0.0321243319018516	-3.43814153281253	411	176	0.0559440559440559	3146	8202	23511,1801,5589,170689,7841,1798,120526,55757,10055,9487,9919,6484,9695,81562,8733,9972,146712,10342,374378,29843,81929,83475,8813,10026,7039,25870,63917,26503,51809,672,84720,10610,29926,4122,10195,5372,197370,4253,55568,8704,9871,1725,6480,79087,79053,10652,54344,8702,54507,80055,23165,129401,7057,811,966,8818,56913,9126,1938,1603,51564,81876,54872,22870,79902,6811,56052,10113,1984,2673,5279,83696,10274,80267,256435,10282,84447,122553,56160,22872,27095,2677,9063,9554,23636,493861,85365,55291,8775,1029,9945,4351,64841,5283,26984,348995,821,9656,9117,6015,6996,6672,10054,84733,57122,22845,8693,9488,3998,205564,144245,55650,10802,79796,10484,23256,10735,9631,55741,5861,8021,91869,6487,79947,5903,1650,51009,286053,8243,440138,29925,6482,8535,51588,6396,284098,7109,7508,8480,10905,10825,10020,2923,79677,285362,56886,641,5373,5281,9883,7341,1075,4245,9632,79868,51227,5238,9761,10678,56648,375056,5045,22955,29071,1294,51693,10427,51128,2517,84752,7175,63908,1802,199857,2720,79090	NUP188,DPH1,PRKCSH,ADAMTS15,MOGS,DPAGT1,DNAJC24,UGGT2,SAE1,PIGL,SEC16A,ST3GAL4,EDEM1,LMAN2L,GPAA1,NUP153,B3GNTL1,TFG,GALNT18,SENP1,SEH1L,DOHH,DPM1,PIGK,TGFA,SUMF2,GALNT11,SLC17A5,GALNT7,BRCA1,PIGO,ST6GALNAC2,GMPPA,MAN2A2,ALG3,PMM1,NSMCE1,CTAGE5,GALNT10,B4GALT2,SEC24D,DHPS,ST6GAL1,ALG12,ALG8,YKT6,DPM3,B4GALT4,ADAMTSL4,PGAP1,NUP205,NUP35,THBS1,CALR,CD59,DPM2,C1GALT1,SMC3,EEF2,DAD1,HDAC7,RAB1B,PIGG,PPP6R1,NUP85,STX5,ALG1,PREB,EIF5A,GFPT1,PIGC,TRAPPC9,STAG1,EDEM3,ST6GALNAC3,BET1,SYVN1,TRAPPC6B,NDNL2,SEC31A,TRAPPC3,GGCX,PIAS2,SEC22B,NUP62,EID3,ALG2,PPP6R3,NAPA,CDKN2A,GFPT2,MPI,GNPNAT1,PIGH,SEC22A,NUP43,CANX,MDC1,SEC22C,RING1,TDG,SP100,UBA2,CBX2,NUP107,DOLK,GALNT4,PIGB,LMAN1,SENP5,ALG10B,PIGV,SEC24A,ALG9,SEC23A,SCFD1,STAG2,NUP155,EDEM2,RAB1A,NUP214,RFT1,ST3GAL3,DHDDS,RANBP2,DDOST,DERL2,NSMCE2,SMC1A,ALG11,GMPPB,ST3GAL1,CBX4,PIAS4,SEC13,PIGW,TRAPPC10,XPC,RAE1,MAN1A2,NEU3,GNE,PDIA3,SMC6,SUMF1,UGGT1,BLM,PMM2,PIGF,POM121,SUMO1,CTSC,MGAT1,SEC24C,ALG13,PIGP,PGM3,MLEC,B3GNT2,EIF5A2,MIA3,FURIN,SCMH1,C1GALT1C1,COL7A1,TRAPPC2L,SEC24B,SAR1B,FUCA1,B3GNT9,TPR,NAPB,DPH2,ALG14,GLB1,TRAPPC6A
R-HSA-164952	The role of Nef in HIV-1 replication and disease pathogenesis	0.0335499287454614	-3.39472053939796	28	16	0.00508582326764145	3146	8202	2534,1173,160,8905,5879,5062,8907,163,55690,567,375,130340,51606,164,1175,3105	FYN,AP2M1,AP2A1,AP1S2,RAC1,PAK2,AP1M1,AP2B1,PACS1,B2M,ARF1,AP1S3,ATP6V1H,AP1G1,AP2S1,HLA-A
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	0.0335499287454614	-3.39472053939796	28	16	0.00508582326764145	3146	8202	5438,5436,5441,5440,8731,2071,5433,404672,6829,5430,2962,5432,4331,2963,5434,2068	POLR2I,POLR2G,POLR2L,POLR2K,RNMT,ERCC3,POLR2D,GTF2H5,SUPT5H,POLR2A,GTF2F1,POLR2C,MNAT1,GTF2F2,POLR2E,ERCC2
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE	0.0335499287454614	-3.39472053939796	28	16	0.00508582326764145	3146	8202	5438,5436,5441,2071,5440,8731,5433,404672,6829,5430,2962,5432,4331,5434,2963,2068	POLR2I,POLR2G,POLR2L,ERCC3,POLR2K,RNMT,POLR2D,GTF2H5,SUPT5H,POLR2A,GTF2F1,POLR2C,MNAT1,POLR2E,GTF2F2,ERCC2
R-HSA-68952	DNA replication initiation	0.0338403491104003	-3.38610142779614	6	5	0.00158931977113795	3146	8202	5426,5427,5558,5422,5557	POLE,POLE2,PRIM2,POLA1,PRIM1
R-HSA-500753	Pyrimidine biosynthesis	0.0338403491104003	-3.38610142779614	6	5	0.00158931977113795	3146	8202	7298,1723,1635,7372,1854	TYMS,DHODH,DCTD,UMPS,DUT
R-HSA-176417	Phosphorylation of Emi1	0.0338403491104003	-3.38610142779614	6	5	0.00158931977113795	3146	8202	891,983,51343,991,26271	CCNB1,CDK1,FZR1,CDC20,FBXO5
R-HSA-68616	Assembly of the ORC complex at the origin of replication	0.0338403491104003	-3.38610142779614	6	5	0.00158931977113795	3146	8202	4999,5000,23595,23594,5001	ORC2,ORC4,ORC3,ORC6,ORC5
R-HSA-174430	Telomere C-strand synthesis initiation	0.0338403491104003	-3.38610142779614	6	5	0.00158931977113795	3146	8202	5426,5427,5558,5422,5557	POLE,POLE2,PRIM2,POLA1,PRIM1
R-HSA-186797	Signaling by PDGF	0.0343083608444679	-3.37236619811552	345	149	0.047361729179911	3146	8202	7249,4763,5786,6777,5720,1026,3709,5519,5906,5696,5688,5296,5701,10818,5567,64223,7311,4690,9978,208,842,283455,5335,1398,5719,6233,4296,4254,5527,2932,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,814,808,10256,5715,1847,7057,5581,1291,5686,5702,5908,8437,5605,5685,5691,5921,5704,7060,2886,3708,2069,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,1147,5566,1399,5687,4193,6464,6711,115,23198,10213,1027,8503,253260,10768,7414,207,2931,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,5709,80824,6778,5536,9861,4343,5594,5711,1844,23112,673,79109,5716,2309,9491,5708,117145,5781,3717,5717,2065,7314,6774,6199,6709,1843,5694,5170,5692,4303,6654,3164,5295,5045,5747,5710,9564,7316,5595,2885,57761,84078,152559,6776,84292,3265	TSC2,NF1,PTPRA,STAT5B,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,NCK1,RBX1,AKT2,CASP9,KSR2,PLCG1,CRK,PSMD13,RPS27A,MAP3K11,KITLG,PPP2R5C,GSK3B,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,THBS1,PRKCE,COL6A1,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,THBS4,GRB7,ITPR1,EREG,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,CRKL,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,AHCYL1,VCL,AKT1,GSK3A,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,STAT6,PPP5C,PSMD6,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,MAPKAP1,PSMD10,FOXO3,PSMF1,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,STAT3,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,PSMB4,FOXO4,SOS1,NR4A1,PIK3R1,FURIN,PTK2,PSMD4,BCAR1,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,STAT5A,WDR83,HRAS
R-HSA-6782315	tRNA modification in the nucleus and cytosol	0.0352064719374065	-3.34652535142047	39	21	0.0066751430387794	3146	8202	4234,348180,54802,55621,55253,54888,8270,54517,51504,127253,54482,51002,10785,23536,81605,54901,80324,93587,90353,115708,79691	METTL1,CTU2,TRIT1,TRMT1,TYW1,NSUN2,LAGE3,PUS7,TRMT112,TYW3,TRMT13,TPRKB,WDR4,ADAT1,URM1,CDKAL1,PUS1,TRMT10A,CTU1,TRMT61A,QTRTD1
R-HSA-5654738	Signaling by FGFR2	0.0362445390194734	-3.31746655676863	316	137	0.0435473617291799	3146	8202	7249,4763,5786,5720,1026,3709,5519,5906,5696,5688,5296,5701,10818,5567,64223,7311,9978,208,842,283455,5335,5719,6233,4296,4254,5527,2932,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,814,808,10256,5715,1847,5581,5686,5702,5908,8437,5605,5685,5691,5921,5704,3708,2069,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,1147,5566,5687,4193,6464,6711,115,23198,10213,1027,8503,253260,10768,7414,207,2931,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,5709,80824,9861,5536,4343,5594,5711,1844,23112,673,5716,79109,9491,2309,5708,117145,5781,3717,5717,2065,7314,10253,6199,6709,1843,5694,5170,4303,5692,6654,3164,5295,5747,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,NF1,PTPRA,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,PLCG1,PSMD13,RPS27A,MAP3K11,KITLG,PPP2R5C,GSK3B,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,PRKCE,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,ITPR1,EREG,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,AHCYL1,VCL,AKT1,GSK3A,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,PSMD6,PPP5C,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,PSMD10,MAPKAP1,PSMF1,FOXO3,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,SPRY2,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-70268	Pyruvate metabolism	0.0372279189355737	-3.2906962901733	24	14	0.00445009535918627	3146	8202	5160,5467,5164,25874,5163,54704,6256,9123,6566,682,5165,8050,51660,3945	PDHA1,PPARD,PDK2,MPC2,PDK1,PDP1,RXRA,SLC16A3,SLC16A1,BSG,PDK3,PDHX,MPC1,LDHB
R-HSA-937041	IKK complex recruitment mediated by RIP1	0.0372279189355737	-3.2906962901733	24	14	0.00445009535918627	3146	8202	7323,7311,330,6233,3551,7322,1147,7335,148022,7314,7321,329,7334,7316	UBE2D3,UBA52,BIRC3,RPS27A,IKBKB,UBE2D2,CHUK,UBE2V1,TICAM1,UBB,UBE2D1,BIRC2,UBE2N,UBC
R-HSA-5685938	HDR through Single Strand Annealing (SSA)	0.0375868888212437	-3.28109999095948	37	20	0.00635727908455181	3146	8202	5883,5984,2067,5983,5810,11073,10524,2072,672,641,5982,580,80010,83695,9156,25,5888,1763,84126,4361	RAD9A,RFC4,ERCC1,RFC3,RAD1,TOPBP1,KAT5,ERCC4,BRCA1,BLM,RFC2,BARD1,RMI1,RHNO1,EXO1,ABL1,RAD51,DNA2,ATRIP,MRE11A
R-HSA-157579	Telomere Maintenance	0.0392561353202952	-3.23764753307659	78	38	0.0120788302606484	3146	8202	3015,8367,3978,5424,8360,8365,121504,54386,5111,65057,8366,8364,26277,1763,8345,8331,5984,5983,5558,328,5422,8368,1736,10714,5982,5557,8294,8334,3012,5427,5426,3014,10856,5981,8338,7013,55135,5425	H2AFZ,HIST1H4E,LIG1,POLD1,HIST1H4D,HIST1H4H,HIST4H4,TERF2IP,PCNA,ACD,HIST1H4B,HIST1H4C,TINF2,DNA2,HIST1H2BH,HIST1H2AJ,RFC4,RFC3,PRIM2,APEX1,POLA1,HIST1H4L,DKC1,POLD3,RFC2,PRIM1,HIST1H4I,HIST1H2AC,HIST1H2AE,POLE2,POLE,H2AFX,RUVBL2,RFC1,HIST2H2AC,TERF1,WRAP53,POLD2
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.03990163697571	-3.22133792896775	137	63	0.0200254291163382	3146	8202	2033,5879,89953,11311,3831,8358,8350,3661,11004,161882,25942,5566,23028,4097,3833,3799,25,1387,7465,4778,2624,829,653604,3660,3717,3835,64147,50808,55604,5567,8968,9732,8352,10112,2626,221037,56992,23186,5868,830,8357,3832,9927,8165,3796,55669,5889,81930,64145,2627,8351,25970,3065,11127,832,3020,140628,91768,23764,3066,3659,11216,8354	EP300,RAC1,KLC4,VPS45,KLC1,HIST1H3B,HIST1H3A,IRF3,KIF2C,ZFPM1,SIN3A,PRKACA,KDM1A,MAFG,KIFC1,KIF5B,ABL1,CREBBP,WEE1,NFE2,GATA2,CAPZA1,HIST2H3D,IRF2,JAK2,KIF22,KIF9,AK3,LRRC16A,PRKACB,HIST1H3F,DOCK4,HIST1H3C,KIF20A,GATA4,JMJD1C,KIF15,RCOR1,RAB5A,CAPZA2,HIST1H3H,KIF11,MFN2,AKAP1,KIF2A,MFN1,RAD51C,KIF18A,RBSN,GATA6,HIST1H3D,SH2B1,HDAC1,KIF3A,CAPZB,H3F3A,GATA5,CABLES1,MAFF,HDAC2,IRF1,AKAP10,HIST1H3I
R-HSA-190236	Signaling by FGFR	0.0401685092702075	-3.21467194182464	317	137	0.0435473617291799	3146	8202	7249,4763,5786,5720,1026,3709,5519,5906,5696,5688,5296,5701,10818,5567,64223,7311,9978,208,842,283455,5335,5719,6233,4296,4254,5527,2932,5690,5705,409,5700,2549,5528,5689,5693,5245,8649,5713,814,808,10256,5715,1847,5581,5686,5702,5908,8437,5605,5685,5691,5921,5704,3708,2069,192669,200734,685,10142,161742,9462,5683,2475,5894,8826,5037,5604,2064,1147,5566,5687,4193,6464,6711,115,23198,10213,1027,8503,253260,10768,7414,207,2931,8452,5695,1742,1846,3710,2260,8660,817,5529,2534,5706,5709,80824,9861,5536,4343,5594,5711,1844,23112,673,5716,79109,9491,2309,5708,117145,5781,3717,5717,2065,7314,10253,6199,6709,1843,5694,5170,4303,5692,6654,3164,5295,5747,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,NF1,PTPRA,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,PLCG1,PSMD13,RPS27A,MAP3K11,KITLG,PPP2R5C,GSK3B,PSMB2,PSMC5,ARRB2,PSMC1,GAB1,PPP2R5D,PSMB1,PSMB5,PHB,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,PRKCE,PSMA5,PSMC3,RAP1B,RASAL1,MAP2K2,PSMA4,PSMB3,RASA1,PSMC4,ITPR1,EREG,AGO3,SPRED2,BTC,AKAP9,SPRED1,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,CDKN1B,PIK3R3,RICTOR,AHCYL1,VCL,AKT1,GSK3A,CUL3,PSMB7,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,PSMD3,DUSP16,PSMD6,PPP5C,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,PSMD10,MAPKAP1,PSMF1,FOXO3,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,SPRY2,RPS6KB2,SPTAN1,DUSP1,PSMB6,PDPK1,FOXO4,PSMB4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-5218921	VEGFR2 mediated cell proliferation	0.0402857830664964	-3.21175664977642	241	106	0.0336935791481246	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,3709,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,10768,7414,10818,7311,9978,5695,8452,1742,283455,1846,3710,7422,2260,8660,5529,5335,817,2534,5719,6233,5706,80824,5709,4296,5590,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,1844,5689,5693,673,5245,8649,5713,808,5716,8877,10256,5715,9491,1847,5708,3717,5717,2065,7314,5686,5694,6709,1843,5170,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,7316,5921,5595,5704,2885,3708,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,AHCYL1,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,ITPR3,VEGFA,FGFR1,IRS2,PPP2R5E,PLCG1,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,PRKCZ,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,DUSP2,PSMB1,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,SPHK1,CNKSR1,PSMD9,PSMF1,DUSP5,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,PSMB6,SPTAN1,DUSP1,PDPK1,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,ITPR1,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-1253288	Downregulation of ERBB4 signaling	0.0402990055244667	-3.21142848714622	8	6	0.00190718372536554	3146	8202	11059,7311,7314,6233,83737,7316	WWP1,UBA52,UBB,RPS27A,ITCH,UBC
R-HSA-389887	Beta-oxidation of pristanoyl-CoA	0.0402990055244667	-3.21142848714622	8	6	0.00190718372536554	3146	8202	6342,3295,1384,54677,8310,10005	SCP2,HSD17B4,CRAT,CROT,ACOX3,ACOT8
R-HSA-196783	Coenzyme A biosynthesis	0.0402990055244667	-3.21142848714622	8	6	0.00190718372536554	3146	8202	80025,79717,8034,55229,79646,53354	PANK2,PPCS,SLC25A16,PANK4,PANK3,PANK1
R-HSA-1614558	Degradation of cysteine and homocysteine	0.0402990055244667	-3.21142848714622	8	6	0.00190718372536554	3146	8202	51380,58472,6821,1491,7263,1468	CSAD,SQRDL,SUOX,CTH,TST,SLC25A10
R-HSA-211000	Gene Silencing by RNA	0.0408799141196946	-3.19711643387914	130	60	0.0190718372536554	3146	8202	23112,3015,23511,5440,8367,8480,8358,8350,11022,348995,8360,9883,23165,129401,8365,121504,8366,8364,57122,653604,9972,3320,8345,5901,4603,79902,8331,81929,8968,8352,5438,5436,5441,10526,113802,122402,5433,6895,9631,8575,8368,8357,8021,5430,5432,8294,7175,5903,3012,8334,54487,8351,23405,5434,3014,23636,3020,8338,192669,8354	TNRC6B,H2AFZ,NUP188,POLR2K,HIST1H4E,RAE1,HIST1H3B,HIST1H3A,TDRKH,NUP43,HIST1H4D,POM121,NUP205,NUP35,HIST1H4H,HIST4H4,HIST1H4B,HIST1H4C,NUP107,HIST2H3D,NUP153,HSP90AA1,HIST1H2BH,RAN,MYBL1,NUP85,HIST1H2AJ,SEH1L,HIST1H3F,HIST1H3C,POLR2I,POLR2G,POLR2L,IPO8,HENMT1,TDRD9,POLR2D,TARBP2,NUP155,PRKRA,HIST1H4L,HIST1H3H,NUP214,POLR2A,POLR2C,HIST1H4I,TPR,RANBP2,HIST1H2AE,HIST1H2AC,DGCR8,HIST1H3D,DICER1,POLR2E,H2AFX,NUP62,H3F3A,HIST2H2AC,AGO3,HIST1H3I
R-HSA-1839117	Signaling by FGFR1 fusion mutants	0.0423619839337499	-3.1615039242713	18	11	0.0034965034965035	3146	8202	2885,11116,8805,5295,399687,1523,6777,6776,6774,11052,26127	GRB2,FGFR1OP,TRIM24,PIK3R1,MYO18A,CUX1,STAT5B,STAT5A,STAT3,CPSF6,FGFR1OP2
R-HSA-1660514	Synthesis of PIPs at the Golgi membrane	0.0423619839337499	-3.1615039242713	18	11	0.0034965034965035	3146	8202	5298,4952,377,30849,22908,5297,375,9896,200576,55697,55361	PI4KB,OCRL,ARF3,PIK3R4,SACM1L,PI4KA,ARF1,FIG4,PIKFYVE,VAC14,PI4K2A
R-HSA-73780	RNA Polymerase III Chain Elongation	0.0423619839337499	-3.1615039242713	18	11	0.0034965034965035	3146	8202	5441,5440,171568,5434,84265,27297,55703,9533,51728,11128,10621	POLR2L,POLR2K,POLR3H,POLR2E,POLR3GL,CRCP,POLR3B,POLR1C,POLR3K,POLR3A,POLR3F
R-HSA-73847	Purine metabolism	0.0428239830649264	-3.15065698134867	33	18	0.00572155117609663	3146	8202	271,4860,5471,158,353,3615,122622,847,3251,51292,1633,471,10606,3614,8833,30833,132,2876	AMPD2,PNP,PPAT,ADSL,APRT,IMPDH2,ADSSL1,CAT,HPRT1,GMPR2,DCK,ATIC,PAICS,IMPDH1,GMPS,NT5C,ADK,GPX1
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.0428239830649264	-3.15065698134867	33	18	0.00572155117609663	3146	8202	10635,10524,672,641,580,80010,9156,5889,84464,79728,5888,80198,197342,7516,1763,4361,7517,23514	RAD51AP1,KAT5,BRCA1,BLM,BARD1,RMI1,EXO1,RAD51C,SLX4,PALB2,RAD51,MUS81,EME2,XRCC2,DNA2,MRE11A,XRCC3,SPIDR
R-HSA-72187	mRNA 3'-end processing	0.0428239830649264	-3.15065698134867	33	18	0.00572155117609663	3146	8202	9295,51362,65109,1479,10250,10978,10921,51585,6430,53981,11051,29894,6427,7307,6429,1478,22916,6428	SRSF11,CDC40,UPF3B,CSTF3,SRRM1,CLP1,RNPS1,PCF11,SRSF5,CPSF2,NUDT21,CPSF1,SRSF2,U2AF1,SRSF4,CSTF2,NCBP2,SRSF3
R-HSA-111367	SLBP independent Processing of Histone Pre-mRNAs	0.0434238792584399	-3.13674577585952	10	7	0.00222504767959313	3146	8202	6636,22916,6635,6637,25888,84967,134353	SNRPF,NCBP2,SNRPE,SNRPG,ZNF473,LSM10,LSM11
R-HSA-73929	Base-Excision Repair, AP Site Formation	0.0434238792584399	-3.13674577585952	10	7	0.00222504767959313	3146	8202	23583,79661,6996,4350,4595,252969,7374	SMUG1,NEIL1,TDG,MPG,MUTYH,NEIL2,UNG
R-HSA-901032	ER Quality Control Compartment (ERQC)	0.0434238792584399	-3.13674577585952	10	7	0.00222504767959313	3146	8202	55757,56886,84447,55741,51009,9695,80267	UGGT2,UGGT1,SYVN1,EDEM2,DERL2,EDEM1,EDEM3
R-HSA-74749	Signal attenuation	0.0434238792584399	-3.13674577585952	10	7	0.00222504767959313	3146	8202	2885,8660,3643,6464,5594,6654,5595	GRB2,IRS2,INSR,SHC1,MAPK1,SOS1,MAPK3
R-HSA-2470946	Cohesin Loading onto Chromatin	0.0434238792584399	-3.13674577585952	10	7	0.00222504767959313	3146	8202	23383,9126,10274,23063,8243,23244,10735	MAU2,SMC3,STAG1,WAPL,SMC1A,PDS5A,STAG2
R-HSA-937042	IRAK2 mediated activation of TAK1 complex	0.0434238792584399	-3.13674577585952	10	7	0.00222504767959313	3146	8202	7311,7314,10454,23118,257397,6233,7316	UBA52,UBB,TAB1,TAB2,TAB3,RPS27A,UBC
R-HSA-164940	Nef mediated downregulation of MHC class I complex cell surface expression	0.0434238792584399	-3.13674577585952	10	7	0.00222504767959313	3146	8202	55690,567,130340,164,8905,3105,8907	PACS1,B2M,AP1S3,AP1G1,AP1S2,HLA-A,AP1M1
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	0.0434238792584399	-3.13674577585952	10	7	0.00222504767959313	3146	8202	7311,7314,10454,23118,257397,6233,7316	UBA52,UBB,TAB1,TAB2,TAB3,RPS27A,UBC
R-HSA-1295596	Spry regulation of FGF signaling	0.0436573762834039	-3.13138302395366	16	10	0.00317863954227591	3146	8202	2885,7311,673,6233,5781,7314,5594,10253,7316,5595	GRB2,UBA52,BRAF,RPS27A,PTPN11,UBB,MAPK1,SPRY2,UBC,MAPK3
R-HSA-69183	Processive synthesis on the lagging strand	0.0436573762834039	-3.13138302395366	16	10	0.00317863954227591	3146	8202	5111,328,5558,5422,1763,3978,5424,10714,5425,5557	PCNA,APEX1,PRIM2,POLA1,DNA2,LIG1,POLD1,POLD3,POLD2,PRIM1
R-HSA-168898	Toll-Like Receptors Cascades	0.0438513970626046	-3.12694870063487	140	64	0.0203432930705658	3146	8202	5599,7323,23291,3146,26052,257397,5604,1660,30849,8454,4205,1147,3661,9252,329,8411,5519,5606,466,6196,8651,10010,3551,5601,51135,5781,1785,4791,841,7321,5598,7314,1386,5970,4214,29110,7311,5609,330,7867,51295,7335,1846,10333,7316,5595,64145,10392,23118,1845,6233,5608,7322,148022,4793,10454,79155,5594,5528,170506,6416,7334,6197,114609	MAPK8,UBE2D3,FBXW11,HMGB1,DNM3,TAB3,MAP2K1,DHX9,PIK3R4,CUL1,MEF2A,CHUK,IRF3,RPS6KA5,BIRC2,EEA1,PPP2R1B,MAP2K3,ATF1,RPS6KA2,SOCS1,TANK,IKBKB,MAPK9,IRAK4,PTPN11,DNM2,NFKB2,CASP8,UBE2D1,MAPK7,UBB,ATF2,RELA,MAP3K1,TBK1,UBA52,MAP2K7,BIRC3,MAPKAPK3,ECSIT,UBE2V1,DUSP4,TLR6,UBC,MAPK3,RBSN,NOD1,TAB2,DUSP3,RPS27A,MAP2K6,UBE2D2,TICAM1,NFKBIB,TAB1,TNIP2,MAPK1,PPP2R5D,DHX36,MAP2K4,UBE2N,RPS6KA3,TIRAP
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	0.0440195387036277	-3.1231216821839	254	111	0.0352828989192626	3146	8202	10142,685,200734,161742,9462,4763,5683,5786,8826,5894,5037,5604,2064,6777,5720,5566,4067,5519,1399,5906,5696,5687,6464,5688,6711,5296,5701,23198,10213,8503,7414,10818,7311,9978,5777,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,1398,5719,5706,6233,80824,5709,4296,4254,5690,5527,5705,9861,5536,409,5594,5528,5700,5711,5689,1844,3636,5693,673,5245,8649,5713,5716,808,10256,5715,9491,1847,5708,5781,3717,5717,2065,7314,5686,5694,6709,1843,5692,6654,5295,5702,5908,8437,5747,7525,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,6776,7534,84292,3265	AKAP9,BTC,SPRED2,SPRED1,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,STAT5B,PSME1,PRKACA,LYN,PPP2R1B,CRKL,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PIK3R2,PSMC2,PSME4,PSMD14,PIK3R3,VCL,FRS2,UBA52,RBX1,PTPN6,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,CRK,PSMD13,PSMC6,RPS27A,DUSP16,PSMD3,MAP3K11,KITLG,PSMB2,PPP2R5C,PSMC5,PSMD6,PPP5C,ARRB2,MAPK1,PPP2R5D,PSMC1,PSMD5,PSMB1,DUSP2,INPPL1,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,PSMD10,CALM3,CNKSR1,PSMD9,PSMF1,DUSP5,PSMD2,PTPN11,JAK2,PSMD11,ERBB3,UBB,PSMA5,PSMB6,SPTAN1,DUSP1,PSMB4,SOS1,PIK3R1,PSMC3,RAP1B,RASAL1,PTK2,YES1,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,STAT5A,YWHAZ,WDR83,HRAS
R-HSA-68884	Mitotic Telophase/Cytokinesis	0.044486659400225	-3.11256592351457	14	9	0.00286077558804832	3146	8202	9126,10274,10112,23063,8243,10735,23383,10726,23244	SMC3,STAG1,KIF20A,WAPL,SMC1A,STAG2,MAU2,NUDC,PDS5A
R-HSA-203615	eNOS activation	0.0445626804716483	-3.11085853096116	12	8	0.00254291163382072	3146	8202	23576,23564,207,808,10434,3320,857,340481	DDAH1,DDAH2,AKT1,CALM3,LYPLA1,HSP90AA1,CAV1,ZDHHC21
R-HSA-381033	ATF6-alpha activates chaperones	0.0445626804716483	-3.11085853096116	12	8	0.00254291163382072	3146	8202	811,468,7494,4802,4801,8720,1649,51360	CALR,ATF4,XBP1,NFYC,NFYB,MBTPS1,DDIT3,MBTPS2
R-HSA-5620920	Cargo trafficking to the periciliary membrane	0.0445729910090951	-3.11062718615113	51	26	0.00826446280991736	3146	8202	10576,129880,585,7203,79738,23265,117177,8195,27241,8729,8766,10640,378,166379,403,22948,84100,9727,4218,6950,5147,582,50807,60412,149371,55770	CCT2,BBS5,BBS4,CCT3,BBS10,EXOC7,RAB3IP,MKKS,BBS9,GBF1,RAB11A,EXOC5,ARF4,BBS12,ARL3,CCT5,ARL6,RAB11FIP3,RAB8A,TCP1,PDE6D,BBS1,ASAP1,EXOC4,EXOC8,EXOC2
R-HSA-2682334	EPH-Ephrin signaling	0.0446965088260021	-3.10785988273933	95	45	0.0143038779402416	3146	8202	10398,1173,8218,71,102,10096,7410,5879,10093,4628,83464,4067,1947,10092,5062,5664,163,4637,3320,2050,10097,9475,3985,6453,2049,387,51107,7525,5747,7422,10552,5921,2534,1969,1945,3984,8976,160,1213,60,6093,10109,1175,3265,23385	MYL9,AP2M1,CLTCL1,ACTG1,ADAM10,ACTR3,VAV2,RAC1,ARPC4,MYH10,APH1B,LYN,EFNB1,ARPC5,PAK2,PSEN2,AP2B1,MYL6,HSP90AA1,EPHB4,ACTR2,ROCK2,LIMK2,ITSN1,EPHB3,RHOA,APH1A,YES1,PTK2,VEGFA,ARPC1A,RASA1,FYN,EPHA2,EFNA4,LIMK1,WASL,AP2A1,CLTC,ACTB,ROCK1,ARPC2,AP2S1,HRAS,NCSTN
R-HSA-168928	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	0.0451713273789744	-3.09729274345175	81	39	0.012396694214876	3146	8202	55593,7323,2033,3146,7186,8887,1660,51191,1147,80143,3661,1387,9246,7706,10010,3551,3660,84282,4791,7314,7321,841,5970,5094,4214,7311,29110,7128,83737,9140,9636,7316,6233,7322,9474,4793,64135,170506,3659	OTUD5,UBE2D3,EP300,HMGB1,TRAF2,TAX1BP1,DHX9,HERC5,CHUK,SIKE1,IRF3,CREBBP,UBE2L6,TRIM25,TANK,IKBKB,IRF2,RNF135,NFKB2,UBB,UBE2D1,CASP8,RELA,PCBP2,MAP3K1,UBA52,TBK1,TNFAIP3,ITCH,ATG12,ISG15,UBC,RPS27A,UBE2D2,ATG5,NFKBIB,IFIH1,DHX36,IRF1
R-HSA-168638	NOD1/2 Signaling Pathway	0.0456943631055775	-3.08578033430067	31	17	0.00540368722186904	3146	8202	7128,330,257397,83737,842,1147,7335,329,837,10392,23118,5608,3551,835,841,10454,7334	TNFAIP3,BIRC3,TAB3,ITCH,CASP9,CHUK,UBE2V1,BIRC2,CASP4,NOD1,TAB2,MAP2K6,IKBKB,CASP2,CASP8,TAB1,UBE2N
R-HSA-70171	Glycolysis	0.0456943631055775	-3.08578033430067	31	17	0.00540368722186904	3146	8202	5210,2597,2026,5208,5315,5519,5211,230,226,2027,5224,3098,5223,3101,5528,5214,7167	PFKFB4,GAPDH,ENO2,PFKFB2,PKM,PPP2R1B,PFKL,ALDOC,ALDOA,ENO3,PGAM2,HK1,PGAM1,HK3,PPP2R5D,PFKP,TPI1
R-HSA-180910	Vpr-mediated nuclear import of PICs	0.0456943631055775	-3.08578033430067	31	17	0.00540368722186904	3146	8202	23511,8480,9631,348995,8021,11168,23165,129401,9883,5903,7175,57122,9972,23636,3159,79902,81929	NUP188,RAE1,NUP155,NUP43,NUP214,PSIP1,NUP205,NUP35,POM121,RANBP2,TPR,NUP107,NUP153,NUP62,HMGA1,NUP85,SEH1L
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	0.0487394218976662	-3.02126709179784	29	16	0.00508582326764145	3146	8202	1387,80205,23054,1490,2626,7003,6256,25937,5465,7004,6604,10413,6907,5469,8463,10498	CREBBP,CHD9,NCOA6,CTGF,GATA4,TEAD1,RXRA,WWTR1,PPARA,TEAD4,SMARCD3,YAP1,TBL1X,MED1,TEAD2,CARM1
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	0.0487394218976662	-3.02126709179784	29	16	0.00508582326764145	3146	8202	23511,8480,9631,348995,8021,23165,129401,9883,5903,7175,57122,9972,23636,79902,3837,81929	NUP188,RAE1,NUP155,NUP43,NUP214,NUP205,NUP35,POM121,RANBP2,TPR,NUP107,NUP153,NUP62,NUP85,KPNB1,SEH1L
R-HSA-2586552	Signaling by Leptin	0.0526117926902649	-2.94481498873415	236	103	0.0327399872854418	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,6777,5720,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,9021,8660,5529,817,2534,5719,6233,5706,80824,5709,25970,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,5781,3717,5717,2065,7314,6774,5686,5694,6709,1843,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,7316,5921,5595,5704,2885,84078,2069,152559,6776,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,STAT5B,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,SOCS3,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,SH2B1,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,PTPN11,JAK2,PSMD11,ERBB3,UBB,STAT3,PSMA5,PSMB6,SPTAN1,DUSP1,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,STAT5A,WDR83,HRAS
R-HSA-2424491	DAP12 signaling	0.054212300777691	-2.91484744466824	325	139	0.0441830896376351	3146	8202	7249,4763,5786,5720,1026,3709,5519,5906,5696,5688,5296,5701,10818,5567,64223,7311,9978,208,842,283455,5335,5719,6233,4296,4254,5690,5527,2932,5705,409,5528,5700,2549,5689,5693,5245,7410,8649,5713,814,808,10256,5715,1847,5581,5686,5702,8437,5908,5685,5605,5691,5921,5704,3708,2069,192669,161742,200734,685,10142,9462,5683,2475,5894,8826,5879,5037,5604,2064,1147,5566,5687,4193,6464,6711,115,23198,10213,8503,1027,253260,10768,7414,207,2931,5695,8452,1742,1846,3710,2260,8660,817,5529,2534,5706,80824,5709,5536,9861,4343,5594,5711,1844,23112,673,79109,5716,567,9491,2309,5708,117145,5781,3717,5717,2065,7314,6199,1843,6709,5694,5170,5692,4303,6654,3164,5295,5747,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,NF1,PTPRA,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,PLCG1,PSMD13,RPS27A,MAP3K11,KITLG,PSMB2,PPP2R5C,GSK3B,PSMC5,ARRB2,PPP2R5D,PSMC1,GAB1,PSMB1,PSMB5,PHB,VAV2,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,PRKCE,PSMA5,PSMC3,RASAL1,RAP1B,PSMA4,MAP2K2,PSMB3,RASA1,PSMC4,ITPR1,EREG,AGO3,SPRED1,SPRED2,BTC,AKAP9,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,RAC1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,PIK3R3,CDKN1B,RICTOR,AHCYL1,VCL,AKT1,GSK3A,PSMB7,CUL3,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,DUSP16,PSMD3,PPP5C,PSMD6,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,MAPKAP1,PSMD10,B2M,PSMF1,FOXO3,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,RPS6KB2,DUSP1,SPTAN1,PSMB6,PDPK1,PSMB4,FOXO4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.0552909439492787	-2.89514614608354	68	33	0.0104895104895105	3146	8202	51588,84142,55775,8367,5591,55183,27434,3981,7468,10524,672,9025,9656,8368,580,8360,7341,8365,7520,121504,8294,7336,7158,8366,8364,27343,3014,51720,4361,8345,79184,7334,79840	PIAS4,FAM175A,TDP1,HIST1H4E,PRKDC,RIF1,POLM,LIG4,WHSC1,KAT5,BRCA1,RNF8,MDC1,HIST1H4L,BARD1,HIST1H4D,SUMO1,HIST1H4H,XRCC5,HIST4H4,HIST1H4I,UBE2V2,TP53BP1,HIST1H4B,HIST1H4C,POLL,H2AFX,UIMC1,MRE11A,HIST1H2BH,BRCC3,UBE2N,NHEJ1
R-HSA-5684996	MAPK1/MAPK3 signaling	0.0553203197893486	-2.89461499148377	234	102	0.0324221233312142	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,3572,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,7297,983,2260,8660,5529,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,5781,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,7316,5921,5595,5704,2885,3569,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,IL6ST,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,TYK2,CDK1,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,PTPN11,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,IL6,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-3304347	Loss of Function of SMAD4 in Cancer	0.056397710800088	-2.87532670995279	3	3	0.000953591862682772	3146	8202	4088,4087,4089	SMAD3,SMAD2,SMAD4
R-HSA-2395516	Electron transport from NADPH to Ferredoxin	0.056397710800088	-2.87532670995279	3	3	0.000953591862682772	3146	8202	112812,2232,2230	FDX1L,FDXR,FDX1
R-HSA-111446	Activation of BIM and translocation to mitochondria	0.056397710800088	-2.87532670995279	3	3	0.000953591862682772	3146	8202	5599,10018,8655	MAPK8,BCL2L11,DYNLL1
R-HSA-5339700	TCF7L2 mutants don't bind CTBP	0.056397710800088	-2.87532670995279	3	3	0.000953591862682772	3146	8202	1488,1487,6934	CTBP2,CTBP1,TCF7L2
R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer	0.056397710800088	-2.87532670995279	3	3	0.000953591862682772	3146	8202	4088,4087,4089	SMAD3,SMAD2,SMAD4
R-HSA-162699	Synthesis of dolichyl-phosphate mannose	0.056397710800088	-2.87532670995279	3	3	0.000953591862682772	3146	8202	8818,54344,8813	DPM2,DPM3,DPM1
R-HSA-5620922	BBSome-mediated cargo-targeting to cilium	0.0589167618805461	-2.83162964679771	23	13	0.00413223140495868	3146	8202	22948,84100,10576,6950,582,129880,585,7203,79738,117177,8195,27241,166379	CCT5,ARL6,CCT2,TCP1,BBS1,BBS5,BBS4,CCT3,BBS10,RAB3IP,MKKS,BBS9,BBS12
R-HSA-5693537	Resolution of D-Loop Structures	0.0591380542623079	-2.82788066563492	34	18	0.00572155117609663	3146	8202	10635,10524,672,641,580,80010,9156,5889,84464,79728,5888,80198,197342,7516,1763,4361,7517,23514	RAD51AP1,KAT5,BRCA1,BLM,BARD1,RMI1,EXO1,RAD51C,SLX4,PALB2,RAD51,MUS81,EME2,XRCC2,DNA2,MRE11A,XRCC3,SPIDR
R-HSA-176033	Interactions of Vpr with host cellular proteins	0.0591380542623079	-2.82788066563492	34	18	0.00572155117609663	3146	8202	23511,8480,9631,348995,8021,11168,23165,129401,9883,7175,5903,291,57122,9972,23636,3159,79902,81929	NUP188,RAE1,NUP155,NUP43,NUP214,PSIP1,NUP205,NUP35,POM121,TPR,RANBP2,SLC25A4,NUP107,NUP153,NUP62,HMGA1,NUP85,SEH1L
R-HSA-379726	Mitochondrial tRNA aminoacylation	0.0626206162822195	-2.7706607215127	21	12	0.00381436745073109	3146	8202	3735,124454,2617,92935,23395,57505,55157,10667,23438,80222,51067,79587	KARS,EARS2,GARS,MARS2,LARS2,AARS2,DARS2,FARS2,HARS2,TARS2,YARS2,CARS2
R-HSA-5620916	VxPx cargo-targeting to cilium	0.0626206162822195	-2.7706607215127	21	12	0.00381436745073109	3146	8202	9727,4218,50807,60412,149371,55770,117177,23265,8729,10640,8766,378	RAB11FIP3,RAB8A,ASAP1,EXOC4,EXOC8,EXOC2,RAB3IP,EXOC7,GBF1,EXOC5,RAB11A,ARF4
R-HSA-2871796	FCERI mediated MAPK activation	0.0664017077702928	-2.71203250339837	248	107	0.0340114431023522	3146	8202	5599,10142,685,200734,161742,9462,4763,5683,5786,8826,5894,5037,5879,5604,2064,5720,4067,5519,5906,5696,5687,6464,5688,6711,5701,23198,10213,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,5335,2534,5719,5706,6233,80824,5709,4296,4254,5690,5527,5705,9861,5536,409,5594,5528,5700,5711,5689,1844,673,5693,5245,7410,8649,5713,5716,808,10256,5715,9491,1847,5708,5062,5601,3717,5717,2065,7314,5686,5694,6709,1843,4214,5692,5609,6654,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,84292,6416,3265	MAPK8,AKAP9,BTC,SPRED2,SPRED1,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,RAC1,MAP2K1,ERBB2,PSME1,LYN,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSME4,PSMD14,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,PLCG1,FYN,PSMD13,PSMC6,RPS27A,DUSP16,PSMD3,MAP3K11,KITLG,PSMB2,PPP2R5C,PSMC5,PSMD6,PPP5C,ARRB2,MAPK1,PPP2R5D,PSMC1,PSMD5,PSMB1,DUSP2,BRAF,PSMB5,PHB,VAV2,LAMTOR3,PSMD7,PSMD10,CALM3,CNKSR1,PSMD9,PSMF1,DUSP5,PSMD2,PAK2,MAPK9,JAK2,PSMD11,ERBB3,UBB,PSMA5,PSMB6,SPTAN1,DUSP1,MAP3K1,PSMB4,MAP2K7,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,MAP2K4,HRAS
R-HSA-110320	Translesion Synthesis by POLH	0.0664298876304353	-2.71160820885488	19	11	0.0034965034965035	3146	8202	7353,5984,5111,5983,7311,6233,5981,7314,5982,5429,7316	UFD1L,RFC4,PCNA,RFC3,UBA52,RPS27A,RFC1,UBB,RFC2,POLH,UBC
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.0684197278841913	-2.68209407657898	39	20	0.00635727908455181	3146	8202	5883,5984,5983,5810,11073,10524,1111,672,641,5982,580,80010,83695,9156,5889,5888,7516,1763,84126,4361	RAD9A,RFC4,RFC3,RAD1,TOPBP1,KAT5,CHEK1,BRCA1,BLM,RFC2,BARD1,RMI1,RHNO1,EXO1,RAD51C,RAD51,XRCC2,DNA2,ATRIP,MRE11A
R-HSA-73777	RNA Polymerase I Chain Elongation	0.0695935544629854	-2.66508332422062	88	41	0.0130324221233312	3146	8202	3015,5440,8367,6908,2071,8358,8350,404672,8360,8365,121504,9014,8366,10849,8364,653604,8345,84172,2068,30834,64425,8331,8968,8352,5441,79101,8368,8357,221830,8294,7343,4331,3012,8334,8351,5434,3014,9533,8338,3020,8354	H2AFZ,POLR2K,HIST1H4E,TBP,ERCC3,HIST1H3B,HIST1H3A,GTF2H5,HIST1H4D,HIST1H4H,HIST4H4,TAF1B,HIST1H4B,CD3EAP,HIST1H4C,HIST2H3D,HIST1H2BH,POLR1B,ERCC2,ZNRD1,POLR1E,HIST1H2AJ,HIST1H3F,HIST1H3C,POLR2L,TAF1D,HIST1H4L,HIST1H3H,TWISTNB,HIST1H4I,UBTF,MNAT1,HIST1H2AE,HIST1H2AC,HIST1H3D,POLR2E,H2AFX,POLR1C,HIST2H2AC,H3F3A,HIST1H3I
R-HSA-187687	Signalling to ERKs	0.0696562378923158	-2.66418302221651	246	106	0.0336935791481246	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,1399,5906,5696,5687,6464,5899,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5898,5529,5335,817,2534,1398,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,5900,808,5716,10256,5715,9491,1847,5708,3717,5717,2065,7314,5686,5694,6709,1843,5692,6654,7867,5702,5908,8437,6016,5747,5710,5605,5685,5691,7316,5921,5595,5704,2885,57498,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,CRKL,RAP1A,PSMB8,PSMA6,SHC1,RALB,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,RALA,PPP2R5E,PLCG1,CAMK2D,FYN,CRK,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,RALGDS,CALM3,PSMD10,CNKSR1,PSMD9,PSMF1,DUSP5,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,PSMB6,SPTAN1,DUSP1,PSMB4,SOS1,MAPKAPK3,PSMC3,RAP1B,RASAL1,RIT1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,KIDINS220,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-1483166	Synthesis of PA	0.0732046451372556	-2.61449640186903	28	15	0.00476795931341386	3146	8202	55326,56895,84803,8443,254531,10554,56894,81579,5337,57678,253558,23171,79888,2819,137964	AGPAT5,AGPAT4,GPAT3,GNPAT,LPCAT4,AGPAT1,AGPAT3,PLA2G12A,PLD1,GPAM,LCLAT1,GPD1L,LPCAT1,GPD1,GPAT4
R-HSA-3322077	Glycogen synthesis	0.0740483758463946	-2.60303667171083	15	9	0.00286077558804832	3146	8202	2632,5236,7311,7360,55276,6233,5507,7314,7316	GBE1,PGM1,UBA52,UGP2,PGM2,RPS27A,PPP1R3C,UBB,UBC
R-HSA-4419969	Depolymerisation of the Nuclear Lamina	0.0740483758463946	-2.60303667171083	15	9	0.00286077558804832	3146	8202	221496,2010,23592,891,64900,255919,983,4000,7112	LEMD2,EMD,LEMD3,CCNB1,LPIN3,CNEP1R1,CDK1,LMNA,TMPO
R-HSA-5358751	S45 mutants of beta-catenin aren't phosphorylated	0.0740483758463946	-2.60303667171083	15	9	0.00286077558804832	3146	8202	5529,1499,139285,2932,5527,324,1452,5528,5519	PPP2R5E,CTNNB1,AMER1,GSK3B,PPP2R5C,APC,CSNK1A1,PPP2R5D,PPP2R1B
R-HSA-3134975	Regulation of innate immune responses to cytosolic DNA	0.0740483758463946	-2.60303667171083	15	9	0.00286077558804832	3146	8202	29110,7311,51428,6233,23220,6737,3661,7314,7316	TBK1,UBA52,DDX41,RPS27A,DTX4,TRIM21,IRF3,UBB,UBC
R-HSA-5358747	S33 mutants of beta-catenin aren't phosphorylated	0.0740483758463946	-2.60303667171083	15	9	0.00286077558804832	3146	8202	5529,1499,139285,2932,5527,324,1452,5528,5519	PPP2R5E,CTNNB1,AMER1,GSK3B,PPP2R5C,APC,CSNK1A1,PPP2R5D,PPP2R1B
R-HSA-4839743	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	0.0740483758463946	-2.60303667171083	15	9	0.00286077558804832	3146	8202	5529,1499,139285,2932,5527,324,1452,5528,5519	PPP2R5E,CTNNB1,AMER1,GSK3B,PPP2R5C,APC,CSNK1A1,PPP2R5D,PPP2R1B
R-HSA-5358752	T41 mutants of beta-catenin aren't phosphorylated	0.0740483758463946	-2.60303667171083	15	9	0.00286077558804832	3146	8202	5529,1499,139285,2932,5527,324,1452,5528,5519	PPP2R5E,CTNNB1,AMER1,GSK3B,PPP2R5C,APC,CSNK1A1,PPP2R5D,PPP2R1B
R-HSA-5358749	S37 mutants of beta-catenin aren't phosphorylated	0.0740483758463946	-2.60303667171083	15	9	0.00286077558804832	3146	8202	5529,1499,139285,2932,5527,324,1452,5528,5519	PPP2R5E,CTNNB1,AMER1,GSK3B,PPP2R5C,APC,CSNK1A1,PPP2R5D,PPP2R1B
R-HSA-5339716	Misspliced GSK3beta mutants stabilize beta-catenin	0.0740483758463946	-2.60303667171083	15	9	0.00286077558804832	3146	8202	5529,1499,139285,2932,5527,324,1452,5528,5519	PPP2R5E,CTNNB1,AMER1,GSK3B,PPP2R5C,APC,CSNK1A1,PPP2R5D,PPP2R1B
R-HSA-5099900	WNT5A-dependent internalization of FZD4	0.0740483758463946	-2.60303667171083	15	9	0.00286077558804832	3146	8202	1173,8322,160,1213,163,409,1175,1856,7474	AP2M1,FZD4,AP2A1,CLTC,AP2B1,ARRB2,AP2S1,DVL2,WNT5A
R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.074953461104736	-2.59088787665069	5	4	0.00127145581691036	3146	8202	2033,1387,3661,1499	EP300,CREBBP,IRF3,CTNNB1
R-HSA-111464	SMAC-mediated dissociation of IAP:caspase complexes	0.074953461104736	-2.59088787665069	5	4	0.00127145581691036	3146	8202	56616,836,840,842	DIABLO,CASP3,CASP7,CASP9
R-HSA-1614517	Sulfide oxidation to sulfate	0.074953461104736	-2.59088787665069	5	4	0.00127145581691036	3146	8202	58472,6821,7263,1468	SQRDL,SUOX,TST,SLC25A10
R-HSA-111461	Cytochrome c-mediated apoptotic response	0.074953461104736	-2.59088787665069	5	4	0.00127145581691036	3146	8202	836,840,317,842	CASP3,CASP7,APAF1,CASP9
R-HSA-157881	Cyclin B2 mediated events	0.074953461104736	-2.59088787665069	5	4	0.00127145581691036	3146	8202	993,995,9133,983	CDC25A,CDC25C,CCNB2,CDK1
R-HSA-111463	SMAC binds to IAPs	0.074953461104736	-2.59088787665069	5	4	0.00127145581691036	3146	8202	56616,836,840,842	DIABLO,CASP3,CASP7,CASP9
R-HSA-111459	Activation of caspases through apoptosome-mediated cleavage	0.074953461104736	-2.59088787665069	5	4	0.00127145581691036	3146	8202	836,840,317,842	CASP3,CASP7,APAF1,CASP9
R-HSA-111469	SMAC-mediated apoptotic response	0.074953461104736	-2.59088787665069	5	4	0.00127145581691036	3146	8202	56616,836,840,842	DIABLO,CASP3,CASP7,CASP9
R-HSA-446210	Synthesis of UDP-N-acetyl-glucosamine	0.074953461104736	-2.59088787665069	5	4	0.00127145581691036	3146	8202	2673,9945,64841,5238	GFPT1,GFPT2,GNPNAT1,PGM3
R-HSA-71387	Metabolism of carbohydrates	0.0754116813562746	-2.58479309081836	274	117	0.0371900826446281	3146	8202	2632,11046,6517,23511,283464,7360,5837,4191,57214,5507,2131,348995,347734,6382,5566,2132,9435,5519,10675,6484,5255,2806,230,9061,57122,231,3373,9972,1836,5256,6888,5567,81929,55454,11261,2597,7311,25796,5208,9631,8021,6487,10327,5903,10855,51181,6233,2539,51363,226,8402,92126,9953,6482,54480,3795,5528,7167,5214,8704,22934,266722,9942,6526,50515,2026,55276,8480,808,8604,113189,22856,8702,6120,9883,23165,129401,3038,5211,55501,2027,1468,6548,5106,7314,3101,178,3425,79902,5261,6576,5210,5236,10678,8509,5315,92579,7316,5226,26035,3423,7175,6448,221914,5091,23636,4190,9469,5224,2720,11041,3098,3073,5223,11285,9653,2582	GBE1,SLC35D2,SLC2A4,NUP188,GXYLT1,UGP2,PYGM,MDH2,CEMIP,PPP1R3C,EXT1,NUP43,SLC35B2,SDC1,PRKACA,EXT2,CHST2,PPP2R1B,CSPG5,ST3GAL4,PHKA1,GOT2,ALDOC,PAPSS1,NUP107,AKR1B1,HYAL1,NUP153,SLC26A2,PHKA2,TALDO1,PRKACB,SEH1L,CSGALNACT2,CHP1,GAPDH,UBA52,PGLS,PFKFB2,NUP155,NUP214,ST3GAL3,AKR1A1,RANBP2,HPSE,DCXR,RPS27A,G6PD,CHST15,ALDOA,SLC25A11,DSEL,HS3ST3B1,ST3GAL1,CHPF2,KHK,PPP2R5D,TPI1,PFKP,B4GALT2,RPIA,HS6ST3,XYLB,SLC5A3,CHST11,ENO2,PGM2,RAE1,CALM3,SLC25A12,CHST14,CHSY1,B4GALT4,RPE,POM121,NUP205,NUP35,HAS3,PFKL,CHST12,ENO3,SLC25A10,SLC9A1,PCK2,UBB,HK3,AGL,IDUA,NUP85,PHKG2,SLC25A1,PFKFB4,PGM1,B3GNT2,NDST2,PKM,G6PC3,UBC,PGD,GLCE,IDS,TPR,SGSH,GPC2,PC,NUP62,MDH1,CHST3,PGAM2,GLB1,B4GAT1,HK1,HEXA,PGAM1,B4GALT7,HS2ST1,GALE
R-HSA-446652	Interleukin-1 signaling	0.0766696019277458	-2.56824997344587	44	22	0.00699300699300699	3146	8202	4215,23291,7311,257397,5604,8454,1147,7335,7316,8878,10392,23118,6233,5608,51135,3551,7314,10454,79155,7334,3556,6416	MAP3K3,FBXW11,UBA52,TAB3,MAP2K1,CUL1,CHUK,UBE2V1,UBC,SQSTM1,NOD1,TAB2,RPS27A,MAP2K6,IRAK4,IKBKB,UBB,TAB1,TNIP2,UBE2N,IL1RAP,MAP2K4
R-HSA-879415	Advanced glycosylation endproduct receptor signaling	0.0775447493029072	-2.55690009889996	13	8	0.00254291163382072	3146	8202	3146,1650,3958,5589,829,830,5594,5595	HMGB1,DDOST,LGALS3,PRKCSH,CAPZA1,CAPZA2,MAPK1,MAPK3
R-HSA-5210891	Uptake and function of anthrax toxins	0.0775447493029072	-2.55690009889996	13	8	0.00254291163382072	3146	8202	5609,5608,5045,5604,808,5605,6416,5606	MAP2K7,MAP2K6,FURIN,MAP2K1,CALM3,MAP2K2,MAP2K4,MAP2K3
R-HSA-2995383	Initiation of Nuclear Envelope Reformation	0.0775447493029072	-2.55690009889996	13	8	0.00254291163382072	3146	8202	23141,221496,2010,23592,7444,5520,4000,7112	ANKLE2,LEMD2,EMD,LEMD3,VRK2,PPP2R2A,LMNA,TMPO
R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	0.0775447493029072	-2.55690009889996	13	8	0.00254291163382072	3146	8202	163,1173,2535,7855,1175,160,1213,7474	AP2B1,AP2M1,FZD2,FZD5,AP2S1,AP2A1,CLTC,WNT5A
R-HSA-2995410	Nuclear Envelope Reassembly	0.0775447493029072	-2.55690009889996	13	8	0.00254291163382072	3146	8202	23141,221496,2010,23592,7444,5520,4000,7112	ANKLE2,LEMD2,EMD,LEMD3,VRK2,PPP2R2A,LMNA,TMPO
R-HSA-2564830	Cytosolic iron-sulfur cluster assembly	0.0775447493029072	-2.55690009889996	13	8	0.00254291163382072	3146	8202	64210,9391,64428,27158,2068,51647,5424,57019	MMS19,CIAO1,NARFL,NDOR1,ERCC2,FAM96B,POLD1,CIAPIN1
R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	0.0786587362112557	-2.54263657858026	26	14	0.00445009535918627	3146	8202	9156,5889,79728,5888,10635,1763,7516,4361,10524,7517,672,641,580,80010	EXO1,RAD51C,PALB2,RAD51,RAD51AP1,DNA2,XRCC2,MRE11A,KAT5,XRCC3,BRCA1,BLM,BARD1,RMI1
R-HSA-77387	Insulin receptor recycling	0.0786587362112557	-2.54263657858026	26	14	0.00445009535918627	3146	8202	3643,51382,10312,523,537,535,23545,527,51606,528,529,9114,8992,9550	INSR,ATP6V1D,TCIRG1,ATP6V1A,ATP6AP1,ATP6V0A1,ATP6V0A2,ATP6V0C,ATP6V1H,ATP6V1C1,ATP6V1E1,ATP6V0D1,ATP6V0E1,ATP6V1G1
R-HSA-169893	Prolonged ERK activation events	0.0798409677053879	-2.52771852649392	235	101	0.0321042593769866	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,1399,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,5335,817,2534,1398,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,7316,5921,5595,5704,2885,57498,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,CRKL,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,PLCG1,CAMK2D,FYN,CRK,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,KIDINS220,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-1980148	Signaling by NOTCH3	0.0804184657159119	-2.52051145608456	11	7	0.00222504767959313	3146	8202	54567,182,102,51107,83464,23385,5664	DLL4,JAG1,ADAM10,APH1A,APH1B,NCSTN,PSEN2
R-HSA-1059683	Interleukin-6 signaling	0.0804184657159119	-2.52051145608456	11	7	0.00222504767959313	3146	8202	3717,6774,3569,7297,3572,9021,5781	JAK2,STAT3,IL6,TYK2,IL6ST,SOCS3,PTPN11
R-HSA-174490	Membrane binding and targetting of GAG proteins	0.0804184657159119	-2.52051145608456	11	7	0.00222504767959313	3146	8202	7251,7311,55048,7314,6233,9397,7316	TSG101,UBA52,VPS37C,UBB,RPS27A,NMT2,UBC
R-HSA-174495	Synthesis And Processing Of GAG, GAGPOL Polyproteins	0.0804184657159119	-2.52051145608456	11	7	0.00222504767959313	3146	8202	7251,7311,55048,7314,6233,9397,7316	TSG101,UBA52,VPS37C,UBB,RPS27A,NMT2,UBC
R-HSA-5655291	Signaling by FGFR4 in disease	0.0804184657159119	-2.52051145608456	11	7	0.00222504767959313	3146	8202	2885,5335,6654,3265,10818,2549,5295	GRB2,PLCG1,SOS1,HRAS,FRS2,GAB1,PIK3R1
R-HSA-1980150	Signaling by NOTCH4	0.0804184657159119	-2.52051145608456	11	7	0.00222504767959313	3146	8202	54567,182,102,51107,83464,23385,5664	DLL4,JAG1,ADAM10,APH1A,APH1B,NCSTN,PSEN2
R-HSA-451927	Interleukin-2 signaling	0.0807552994742312	-2.51633169086895	245	105	0.033375715193897	3146	8202	10142,685,200734,161742,9462,4763,5683,5786,8826,5894,5037,5604,2064,6777,5720,5519,5906,5696,5687,6464,5688,6711,5296,5701,23198,10213,8503,7414,10818,7311,9978,5777,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,5706,6233,80824,5709,4296,4254,2185,5690,5527,5705,9861,5536,409,5594,5528,5700,5711,5689,1844,3636,673,5693,5245,8649,5713,5716,808,10256,5715,9491,1847,5708,3717,5717,2065,7314,5686,5694,6709,1843,5692,6654,5295,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,6776,84292,3265	AKAP9,BTC,SPRED2,SPRED1,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,STAT5B,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PIK3R2,PSMC2,PSME4,PSMD14,PIK3R3,VCL,FRS2,UBA52,RBX1,PTPN6,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,PSMC6,RPS27A,DUSP16,PSMD3,MAP3K11,KITLG,PTK2B,PSMB2,PPP2R5C,PSMC5,PSMD6,PPP5C,ARRB2,MAPK1,PPP2R5D,PSMC1,PSMD5,PSMB1,DUSP2,INPPL1,BRAF,PSMB5,PHB,LAMTOR3,PSMD7,PSMD10,CALM3,CNKSR1,PSMD9,PSMF1,DUSP5,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,PSMB6,SPTAN1,DUSP1,PSMB4,SOS1,PIK3R1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,STAT5A,WDR83,HRAS
R-HSA-182218	Nef Mediated CD8 Down-regulation	0.0811234376496788	-2.51178336269891	7	5	0.00158931977113795	3146	8202	163,1173,51606,1175,160	AP2B1,AP2M1,ATP6V1H,AP2S1,AP2A1
R-HSA-2993913	Clearance of Nuclear Envelope Membranes from Chromatin	0.0811234376496788	-2.51178336269891	7	5	0.00158931977113795	3146	8202	221496,2010,23592,7444,7112	LEMD2,EMD,LEMD3,VRK2,TMPO
R-HSA-111471	Apoptotic factor-mediated response	0.0811234376496788	-2.51178336269891	7	5	0.00158931977113795	3146	8202	56616,836,840,317,842	DIABLO,CASP3,CASP7,APAF1,CASP9
R-HSA-2980767	Activation of NIMA Kinases NEK9, NEK6, NEK7	0.0811234376496788	-2.51178336269891	7	5	0.00158931977113795	3146	8202	891,9133,140609,983,91754	CCNB1,CCNB2,NEK7,CDK1,NEK9
R-HSA-2393930	Phosphate bond hydrolysis by NUDT proteins	0.0811234376496788	-2.51178336269891	7	5	0.00158931977113795	3146	8202	4521,131870,11164,79873,53343	NUDT1,NUDT16,NUDT5,NUDT18,NUDT9
R-HSA-110357	Displacement of DNA glycosylase by APEX1	0.0820302043864167	-2.50066775336487	9	6	0.00190718372536554	3146	8202	23583,6996,328,4350,4595,7374	SMUG1,TDG,APEX1,MPG,MUTYH,UNG
R-HSA-167590	Nef Mediated CD4 Down-regulation	0.0820302043864167	-2.50066775336487	9	6	0.00190718372536554	3146	8202	163,375,1173,51606,1175,160	AP2B1,ARF1,AP2M1,ATP6V1H,AP2S1,AP2A1
R-HSA-198693	AKT phosphorylates targets in the nucleus	0.0820302043864167	-2.50066775336487	9	6	0.00190718372536554	3146	8202	4303,207,3164,2309,208,6199	FOXO4,AKT1,NR4A1,FOXO3,AKT2,RPS6KB2
R-HSA-912526	Interleukin receptor SHC signaling	0.0841826224395207	-2.47476676336277	238	102	0.0324221233312142	3146	8202	10142,685,200734,161742,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5688,6711,5296,5701,23198,10213,8503,7414,10818,7311,9978,5777,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,5706,6233,80824,5709,4296,4254,5690,5527,5705,9861,5536,409,5594,5528,5700,5711,5689,1844,3636,673,5693,5245,8649,5713,5716,808,10256,5715,9491,1847,5708,3717,5717,2065,7314,5686,5694,6709,1843,5692,6654,5295,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,84292,3265	AKAP9,BTC,SPRED2,SPRED1,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PIK3R2,PSMC2,PSME4,PSMD14,PIK3R3,VCL,FRS2,UBA52,RBX1,PTPN6,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,PSMC6,RPS27A,DUSP16,PSMD3,MAP3K11,KITLG,PSMB2,PPP2R5C,PSMC5,PSMD6,PPP5C,ARRB2,MAPK1,PPP2R5D,PSMC1,PSMD5,PSMB1,DUSP2,INPPL1,BRAF,PSMB5,PHB,LAMTOR3,PSMD7,PSMD10,CALM3,CNKSR1,PSMD9,PSMF1,DUSP5,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,PSMB6,SPTAN1,DUSP1,PSMB4,SOS1,PIK3R1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-1614635	Sulfur amino acid metabolism	0.0845490308144587	-2.47042366657186	24	13	0.00413223140495868	3146	8202	58478,58472,6821,2729,84245,1468,51380,51074,55748,4507,1491,4552,7263	ENOPH1,SQRDL,SUOX,GCLC,MRI1,SLC25A10,CSAD,APIP,CNDP2,MTAP,CTH,MTRR,TST
R-HSA-73848	Pyrimidine metabolism	0.0845490308144587	-2.47042366657186	24	13	0.00413223140495868	3146	8202	1890,1633,7378,1854,7298,1723,1635,30833,7372,1806,51251,56953,7084	TYMP,DCK,UPP1,DUT,TYMS,DHODH,DCTD,NT5C,UMPS,DPYD,NT5C3A,NT5M,TK2
R-HSA-5694530	Cargo concentration in the ER	0.0854157528338779	-2.46022473578507	33	17	0.00540368722186904	3146	8202	10802,966,51128,10427,10484,1075,9871,81562,7039,9632,375056,4253,9554,1294,3998,10113,6811	SEC24A,CD59,SAR1B,SEC24B,SEC23A,CTSC,SEC24D,LMAN2L,TGFA,SEC24C,MIA3,CTAGE5,SEC22B,COL7A1,LMAN1,PREB,STX5
R-HSA-416482	G alpha (12/13) signalling events	0.0867145279523708	-2.44513384346193	75	35	0.0111252383979657	3146	8202	391,50650,2785,389,7410,5879,7204,2782,2783,5364,57449,10681,5296,9138,8503,9181,9828,9475,6453,6655,387,6654,10276,5295,84033,23365,11214,388,2768,59345,6093,10672,23229,64857,2245	RHOG,ARHGEF3,GNG3,RHOC,VAV2,RAC1,TRIO,GNB1,GNB2,PLXNB1,PLEKHG5,GNB5,PIK3R2,ARHGEF1,PIK3R3,ARHGEF2,ARHGEF17,ROCK2,ITSN1,SOS2,RHOA,SOS1,NET1,PIK3R1,OBSCN,ARHGEF12,AKAP13,RHOB,GNA12,GNB4,ROCK1,GNA13,ARHGEF9,PLEKHG2,FGD1
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.0880329549860545	-2.43004404612935	87	40	0.0127145581691036	3146	8202	2033,3015,8367,6597,10524,8358,8350,90780,5929,8360,8365,121504,1387,1499,8366,8364,283149,653604,9070,8345,8331,8968,8352,7091,123169,7090,26108,8368,4221,8357,6934,8294,3012,8334,8351,3014,3065,8338,3020,8354	EP300,H2AFZ,HIST1H4E,SMARCA4,KAT5,HIST1H3B,HIST1H3A,PYGO2,RBBP5,HIST1H4D,HIST1H4H,HIST4H4,CREBBP,CTNNB1,HIST1H4B,HIST1H4C,BCL9L,HIST2H3D,ASH2L,HIST1H2BH,HIST1H2AJ,HIST1H3F,HIST1H3C,TLE4,LEO1,TLE3,PYGO1,HIST1H4L,MEN1,HIST1H3H,TCF7L2,HIST1H4I,HIST1H2AE,HIST1H2AC,HIST1H3D,H2AFX,HDAC1,HIST2H2AC,H3F3A,HIST1H3I
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	0.0909096256155359	-2.39788939104477	22	12	0.00381436745073109	3146	8202	5984,5111,5983,5426,328,5427,3978,5981,10714,5424,5982,5425	RFC4,PCNA,RFC3,POLE,APEX1,POLE2,LIG1,RFC1,POLD3,POLD1,RFC2,POLD2
R-HSA-69273	Cyclin A/B1 associated events during G2/M transition	0.0909096256155359	-2.39788939104477	22	12	0.00381436745073109	3146	8202	4331,993,7465,890,7514,5520,9088,891,9133,995,983,5519	MNAT1,CDC25A,WEE1,CCNA2,XPO1,PPP2R2A,PKMYT1,CCNB1,CCNB2,CDC25C,CDK1,PPP2R1B
R-HSA-373753	Nephrin interactions	0.0909096256155359	-2.39788939104477	22	12	0.00381436745073109	3146	8202	2534,8573,23607,4690,8826,8976,6711,5296,5295,81,87,6709	FYN,CASK,CD2AP,NCK1,IQGAP1,WASL,SPTBN1,PIK3R2,PIK3R1,ACTN4,ACTN1,SPTAN1
R-HSA-5654700	FRS-mediated FGFR2 signaling	0.0919971735975022	-2.3859974241713	229	98	0.0311506675143039	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,5781,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,PTPN11,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-5654693	FRS-mediated FGFR1 signaling	0.0919971735975022	-2.3859974241713	229	98	0.0311506675143039	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,5781,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,PTPN11,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-5654712	FRS-mediated FGFR4 signaling	0.0919971735975022	-2.3859974241713	229	98	0.0311506675143039	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,5781,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,PTPN11,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-5654706	FRS-mediated FGFR3 signaling	0.0919971735975022	-2.3859974241713	229	98	0.0311506675143039	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,5781,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,PTPN11,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-170984	ARMS-mediated activation	0.0968207173247216	-2.33489428564943	232	99	0.0314685314685315	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,1398,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,57498,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,CRK,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KIDINS220,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-1912422	Pre-NOTCH Expression and Processing	0.097295621090092	-2.33000129501572	45	22	0.00699300699300699	3146	8202	2033,23112,2648,3955,56983,1871,5045,5870,23509,6487,1387,6484,22938,488,10046,7027,3516,7029,9794,4343,192669,55534	EP300,TNRC6B,KAT2A,LFNG,POGLUT1,E2F3,FURIN,RAB6A,POFUT1,ST3GAL3,CREBBP,ST3GAL4,SNW1,ATP2A2,MAMLD1,TFDP1,RBPJ,TFDP2,MAML1,MOV10,AGO3,MAML3
R-HSA-2299718	Condensation of Prophase Chromosomes	0.0992055010383242	-2.31056181221346	71	33	0.0104895104895105	3146	8202	3015,8367,8358,8350,891,8360,8365,121504,8366,387893,8364,653604,8345,29781,8331,10051,8968,8352,23133,10592,8368,8357,983,8294,8334,23310,3012,8351,6418,3014,8338,3020,8354	H2AFZ,HIST1H4E,HIST1H3B,HIST1H3A,CCNB1,HIST1H4D,HIST1H4H,HIST4H4,HIST1H4B,KMT5A,HIST1H4C,HIST2H3D,HIST1H2BH,NCAPH2,HIST1H2AJ,SMC4,HIST1H3F,HIST1H3C,PHF8,SMC2,HIST1H4L,HIST1H3H,CDK1,HIST1H4I,HIST1H2AC,NCAPD3,HIST1H2AE,HIST1H3D,SET,H2AFX,HIST2H2AC,H3F3A,HIST1H3I
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	0.099417384323282	-2.30842828802318	29	15	0.00476795931341386	3146	8202	7175,5903,23511,8480,57122,23636,9972,9631,348995,8021,79902,9883,23165,129401,81929	TPR,RANBP2,NUP188,RAE1,NUP107,NUP62,NUP153,NUP155,NUP43,NUP214,NUP85,POM121,NUP205,NUP35,SEH1L
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	0.103424738459125	-2.26891109543529	36	18	0.00572155117609663	3146	8202	2885,5335,2534,6464,4690,6654,6786,5777,3708,5295,84876,808,7220,3709,10768,3710,4067,30011	GRB2,PLCG1,FYN,SHC1,NCK1,SOS1,STIM1,PTPN6,ITPR1,PIK3R1,ORAI1,CALM3,TRPC1,ITPR2,AHCYL1,ITPR3,LYN,SH3KBP1
R-HSA-1963640	GRB2 events in ERBB2 signaling	0.106166008607122	-2.2427512910203	228	97	0.0308328035600763	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-1250347	SHC1 events in ERBB4 signaling	0.106166008607122	-2.2427512910203	228	97	0.0308328035600763	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-180336	SHC1 events in EGFR signaling	0.106166008607122	-2.2427512910203	228	97	0.0308328035600763	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-5673001	RAF/MAP kinase cascade	0.106166008607122	-2.2427512910203	228	97	0.0308328035600763	3146	8202	10142,685,200734,161742,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5688,6711,5701,23198,10213,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,5706,6233,80824,5709,4296,4254,5690,5527,5705,9861,5536,409,5594,5528,5700,5711,5689,1844,673,5693,5245,8649,5713,5716,808,10256,5715,9491,1847,5708,3717,5717,2065,7314,5686,5694,6709,1843,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,84292,3265	AKAP9,BTC,SPRED2,SPRED1,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSME4,PSMD14,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,PSMC6,RPS27A,DUSP16,PSMD3,MAP3K11,KITLG,PSMB2,PPP2R5C,PSMC5,PSMD6,PPP5C,ARRB2,MAPK1,PPP2R5D,PSMC1,PSMD5,PSMB1,DUSP2,BRAF,PSMB5,PHB,LAMTOR3,PSMD7,PSMD10,CALM3,CNKSR1,PSMD9,PSMF1,DUSP5,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,PSMB6,SPTAN1,DUSP1,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-179812	GRB2 events in EGFR signaling	0.106166008607122	-2.2427512910203	228	97	0.0308328035600763	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-112412	SOS-mediated signalling	0.106166008607122	-2.2427512910203	228	97	0.0308328035600763	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-1250196	SHC1 events in ERBB2 signaling	0.106166008607122	-2.2427512910203	228	97	0.0308328035600763	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,5921,7316,5595,5704,2885,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,RASA1,UBC,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-170968	Frs2-mediated activation	0.106499061509089	-2.23961910599271	233	99	0.0314685314685315	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,1399,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,5335,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,5747,5710,5605,5685,5691,7316,5921,5595,5704,2885,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,CRKL,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,PLCG1,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-182971	EGFR downregulation	0.107410093747572	-2.23110111857141	27	14	0.00445009535918627	3146	8202	2885,1173,7311,6233,160,58513,29924,163,7314,10253,1175,30011,7316,10252	GRB2,AP2M1,UBA52,RPS27A,AP2A1,EPS15L1,EPN1,AP2B1,UBB,SPRY2,AP2S1,SH3KBP1,UBC,SPRY1
R-HSA-437239	Recycling pathway of L1	0.107410093747572	-2.23110111857141	27	14	0.00445009535918627	3146	8202	26052,1173,6196,1808,160,1785,7430,163,8986,9252,5594,1175,6197,8650	DNM3,AP2M1,RPS6KA2,DPYSL2,AP2A1,DNM2,EZR,AP2B1,RPS6KA4,RPS6KA5,MAPK1,AP2S1,RPS6KA3,NUMB
R-HSA-1834941	STING mediated induction of host immune responses	0.113122518141334	-2.17928381628484	16	9	0.00286077558804832	3146	8202	29110,51428,6778,5591,23220,4361,6737,3661,7520	TBK1,DDX41,STAT6,PRKDC,DTX4,MRE11A,TRIM21,IRF3,XRCC5
R-HSA-109704	PI3K Cascade	0.114038634282184	-2.17121799078819	79	36	0.0114431023521933	3146	8202	7249,2475,5565,92335,5562,8649,30849,64121,10542,57521,5296,117145,5781,6194,5494,1977,10818,64223,5170,207,208,5295,5571,6009,2260,2885,8660,1981,57761,51422,1978,389541,10325,6198,2549,58528	TSC2,MTOR,PRKAB2,STRADA,PRKAA1,LAMTOR3,PIK3R4,RRAGC,LAMTOR5,RPTOR,PIK3R2,THEM4,PTPN11,RPS6,PPM1A,EIF4E,FRS2,MLST8,PDPK1,AKT1,AKT2,PIK3R1,PRKAG1,RHEB,FGFR1,GRB2,IRS2,EIF4G1,TRIB3,PRKAG2,EIF4EBP1,LAMTOR4,RRAGB,RPS6KB1,GAB1,RRAGD
R-HSA-167044	Signalling to RAS	0.117022276834025	-2.14539096201741	239	101	0.0321042593769866	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5899,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5898,5529,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,5900,808,5716,10256,5715,1847,9491,5708,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,7867,5702,5908,8437,5747,5710,5605,5685,5691,7316,5921,5595,5704,2885,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,RALB,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,RALA,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,RALGDS,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,MAPKAPK3,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-376176	Signaling by Robo receptor	0.120746015529365	-2.11406598468031	32	16	0.00508582326764145	3146	8202	6655,4690,6654,5879,80728,6091,55740,5217,10298,25,7408,10487,5062,57522,23122,9353	SOS2,NCK1,SOS1,RAC1,ARHGAP39,ROBO1,ENAH,PFN2,PAK4,ABL1,VASP,CAP1,PAK2,SRGAP1,CLASP2,SLIT2
R-HSA-427359	SIRT1 negatively regulates rRNA Expression	0.12158751688982	-2.10712097187577	65	30	0.00953591862682772	3146	8202	23411,8352,8968,3015,79101,8367,6908,8358,8350,8368,8357,23378,8360,8365,121504,8294,3012,8334,9014,8366,8364,8351,3014,653604,8345,3020,8338,8331,6839,8354	SIRT1,HIST1H3C,HIST1H3F,H2AFZ,TAF1D,HIST1H4E,TBP,HIST1H3B,HIST1H3A,HIST1H4L,HIST1H3H,RRP8,HIST1H4D,HIST1H4H,HIST4H4,HIST1H4I,HIST1H2AE,HIST1H2AC,TAF1B,HIST1H4B,HIST1H4C,HIST1H3D,H2AFX,HIST2H3D,HIST1H2BH,H3F3A,HIST2H2AC,HIST1H2AJ,SUV39H1,HIST1H3I
R-HSA-162658	Golgi Cisternae Pericentriolar Stack Reorganization	0.121622202503641	-2.10683573973831	14	8	0.00254291163382072	3146	8202	5862,5861,891,5594,9133,983,81876,5595	RAB2A,RAB1A,CCNB1,MAPK1,CCNB2,CDK1,RAB1B,MAPK3
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.121622202503641	-2.10683573973831	14	8	0.00254291163382072	3146	8202	5527,2932,5529,324,1452,5528,139285,5519	PPP2R5C,GSK3B,PPP2R5E,APC,CSNK1A1,PPP2R5D,AMER1,PPP2R1B
R-HSA-77595	Processing of Intronless Pre-mRNAs	0.121622202503641	-2.10683573973831	14	8	0.00254291163382072	3146	8202	29894,11051,1479,10978,1478,22916,51585,53981	CPSF1,NUDT21,CSTF3,CLP1,CSTF2,NCBP2,PCF11,CPSF2
R-HSA-428540	Activation of Rac	0.121622202503641	-2.10683573973831	14	8	0.00254291163382072	3146	8202	6655,4690,6654,5062,5879,6091,9353,10298	SOS2,NCK1,SOS1,PAK2,RAC1,ROBO1,SLIT2,PAK4
R-HSA-4839744	truncated APC mutants destabilize the destruction complex	0.121622202503641	-2.10683573973831	14	8	0.00254291163382072	3146	8202	5527,2932,5529,324,1452,5528,139285,5519	PPP2R5C,GSK3B,PPP2R5E,APC,CSNK1A1,PPP2R5D,AMER1,PPP2R1B
R-HSA-69166	Removal of the Flap Intermediate	0.121622202503641	-2.10683573973831	14	8	0.00254291163382072	3146	8202	5111,5558,5422,1763,5424,10714,5425,5557	PCNA,PRIM2,POLA1,DNA2,POLD1,POLD3,POLD2,PRIM1
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.121622202503641	-2.10683573973831	14	8	0.00254291163382072	3146	8202	5527,2932,5529,324,1452,5528,139285,5519	PPP2R5C,GSK3B,PPP2R5E,APC,CSNK1A1,PPP2R5D,AMER1,PPP2R1B
R-HSA-4839735	AXIN mutants destabilize the destruction complex, activating WNT signaling	0.121622202503641	-2.10683573973831	14	8	0.00254291163382072	3146	8202	5527,2932,5529,324,1452,5528,139285,5519	PPP2R5C,GSK3B,PPP2R5E,APC,CSNK1A1,PPP2R5D,AMER1,PPP2R1B
R-HSA-204174	Regulation of pyruvate dehydrogenase (PDH) complex	0.121622202503641	-2.10683573973831	14	8	0.00254291163382072	3146	8202	5160,5467,5164,5165,5163,54704,8050,6256	PDHA1,PPARD,PDK2,PDK3,PDK1,PDP1,PDHX,RXRA
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.121622202503641	-2.10683573973831	14	8	0.00254291163382072	3146	8202	5527,2932,5529,324,1452,5528,139285,5519	PPP2R5C,GSK3B,PPP2R5E,APC,CSNK1A1,PPP2R5D,AMER1,PPP2R1B
R-HSA-418885	DCC mediated attractive signaling	0.121622202503641	-2.10683573973831	14	8	0.00254291163382072	3146	8202	3983,2534,4690,8976,5879,7204,5747,84448	ABLIM1,FYN,NCK1,WASL,RAC1,TRIO,PTK2,ABLIM2
R-HSA-918233	TRAF3-dependent IRF activation pathway	0.121622202503641	-2.10683573973831	14	8	0.00254291163382072	3146	8202	2033,1387,29110,7706,80143,3661,84282,64135	EP300,CREBBP,TBK1,TRIM25,SIKE1,IRF3,RNF135,IFIH1
R-HSA-4839748	AMER1 mutants destabilize the destruction complex	0.121622202503641	-2.10683573973831	14	8	0.00254291163382072	3146	8202	5527,2932,5529,324,1452,5528,139285,5519	PPP2R5C,GSK3B,PPP2R5E,APC,CSNK1A1,PPP2R5D,AMER1,PPP2R1B
R-HSA-187706	Signalling to p38 via RIT and RIN	0.122127936201831	-2.10268612631389	232	98	0.0311506675143039	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,5715,1847,9491,5708,3717,5717,2065,7314,5686,6709,1843,5694,5692,6654,5702,5908,8437,6016,5747,5710,5605,5685,5691,7316,5921,5595,5704,2885,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,PSMD9,DUSP5,PSMF1,PSMD2,JAK2,PSMD11,ERBB3,UBB,PSMA5,SPTAN1,DUSP1,PSMB6,PSMB4,SOS1,PSMC3,RAP1B,RASAL1,RIT1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-70895	Branched-chain amino acid catabolism	0.125810931509399	-2.07297504254986	23	12	0.00381436745073109	3146	8202	4329,36,594,593,3028,56922,38,27034,1629,223,587,55217	ALDH6A1,ACADSB,BCKDHB,BCKDHA,HSD17B10,MCCC1,ACAT1,ACAD8,DBT,ALDH9A1,BCAT2,TMLHE
R-HSA-70614	Amino acid synthesis and interconversion (transamination)	0.125810931509399	-2.07297504254986	23	12	0.00381436745073109	3146	8202	2744,84706,883,440,29968,2806,65263,5832,4942,2752,5723,5831	GLS,GPT2,CCBL1,ASNS,PSAT1,GOT2,PYCRL,ALDH18A1,OAT,GLUL,PSPH,PYCR1
R-HSA-201451	Signaling by BMP	0.125810931509399	-2.07297504254986	23	12	0.00381436745073109	3146	8202	7323,659,9241,92,4090,657,64750,4086,7321,57154,4091,4089	UBE2D3,BMPR2,NOG,ACVR2A,SMAD5,BMPR1A,SMURF2,SMAD1,UBE2D1,SMURF1,SMAD6,SMAD4
R-HSA-3371511	HSF1 activation	0.130616565061381	-2.03548923204081	12	7	0.00222504767959313	3146	8202	3320,10728,7531,10013,1915,3326,3297	HSP90AA1,PTGES3,YWHAE,HDAC6,EEF1A1,HSP90AB1,HSF1
R-HSA-210990	PECAM1 interactions	0.130616565061381	-2.03548923204081	12	7	0.00222504767959313	3146	8202	5335,2534,7525,3685,4067,5777,5781	PLCG1,FYN,YES1,ITGAV,LYN,PTPN6,PTPN11
R-HSA-174414	Processive synthesis on the C-strand of the telomere	0.130616565061381	-2.03548923204081	12	7	0.00222504767959313	3146	8202	3978,5111,328,10714,5424,5425,1763	LIG1,PCNA,APEX1,POLD3,POLD1,POLD2,DNA2
R-HSA-429958	mRNA decay by 3' to 5' exoribonuclease	0.130616565061381	-2.03548923204081	12	7	0.00222504767959313	3146	8202	5393,23404,54512,118460,23016,51010,56915	EXOSC9,EXOSC2,EXOSC4,EXOSC6,EXOSC7,EXOSC3,EXOSC5
R-HSA-202670	ERKs are inactivated	0.130616565061381	-2.03548923204081	12	7	0.00222504767959313	3146	8202	1846,5598,1845,5594,5528,5519,5595	DUSP4,MAPK7,DUSP3,MAPK1,PPP2R5D,PPP2R1B,MAPK3
R-HSA-1474151	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	0.130616565061381	-2.03548923204081	12	7	0.00222504767959313	3146	8202	1719,5805,808,3320,207,2644,2643	DHFR,PTS,CALM3,HSP90AA1,AKT1,GCHFR,GCH1
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	0.130681092452337	-2.03499533253263	30	15	0.00476795931341386	3146	8202	5599,466,6196,1845,5601,4205,1846,5598,1386,9252,5594,5528,5519,6197,5595	MAPK8,ATF1,RPS6KA2,DUSP3,MAPK9,MEF2A,DUSP4,MAPK7,ATF2,RPS6KA5,MAPK1,PPP2R5D,PPP2R1B,RPS6KA3,MAPK3
R-HSA-5621575	CD209 (DC-SIGN) signaling	0.13644274877766	-1.99185017521378	21	11	0.0034965034965035	3146	8202	2033,1387,2534,5894,5062,5970,4067,9252,5566,3265,5567	EP300,CREBBP,FYN,RAF1,PAK2,RELA,LYN,RPS6KA5,PRKACA,HRAS,PRKACB
R-HSA-4641263	Regulation of FZD by ubiquitination	0.13644274877766	-1.99185017521378	21	11	0.0034965034965035	3146	8202	7311,55366,8322,6233,8325,9101,4040,84133,7314,7855,7316	UBA52,LGR4,FZD4,RPS27A,FZD8,USP8,LRP6,ZNRF3,UBB,FZD5,UBC
R-HSA-198753	ERK/MAPK targets	0.13644274877766	-1.99185017521378	21	11	0.0034965034965035	3146	8202	6196,1845,4205,5598,1846,9252,5594,5528,5519,6197,5595	RPS6KA2,DUSP3,MEF2A,MAPK7,DUSP4,RPS6KA5,MAPK1,PPP2R5D,PPP2R1B,RPS6KA3,MAPK3
R-HSA-445144	Signal transduction by L1	0.13644274877766	-1.99185017521378	21	11	0.0034965034965035	3146	8202	7410,5879,3688,5604,3678,3685,8829,5594,5605,2260,5595	VAV2,RAC1,ITGB1,MAP2K1,ITGA5,ITGAV,NRP1,MAPK1,MAP2K2,FGFR1,MAPK3
R-HSA-499943	Synthesis and interconversion of nucleotide di- and triphosphates	0.13644274877766	-1.99185017521378	21	11	0.0034965034965035	3146	8202	7296,203,1841,4830,122481,50484,56474,6240,4833,6241,51727	TXNRD1,AK1,DTYMK,NME1,AK7,RRM2B,CTPS2,RRM1,NME4,RRM2,CMPK1
R-HSA-1660517	Synthesis of PIPs at the late endosome membrane	0.139939692079038	-1.96654372004527	10	6	0.00190718372536554	3146	8202	9896,200576,8898,9110,55697,30849	FIG4,PIKFYVE,MTMR2,MTMR4,VAC14,PIK3R4
R-HSA-381183	ATF6-alpha activates chaperone genes	0.139939692079038	-1.96654372004527	10	6	0.00190718372536554	3146	8202	811,468,4801,1649,7494,4802	CALR,ATF4,NFYB,DDIT3,XBP1,NFYC
R-HSA-193692	Regulated proteolysis of p75NTR	0.139939692079038	-1.96654372004527	10	6	0.00190718372536554	3146	8202	6868,51107,5970,83464,23385,5664	ADAM17,APH1A,RELA,APH1B,NCSTN,PSEN2
R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)	0.141615542359984	-1.95463934131671	28	14	0.00445009535918627	3146	8202	7311,6233,51510,9525,7251,11267,27183,51028,7314,25978,55048,84313,7316,92421	UBA52,RPS27A,CHMP5,VPS4B,TSG101,SNF8,VPS4A,VPS36,UBB,CHMP2B,VPS37C,VPS25,UBC,CHMP4C
R-HSA-168330	Viral RNP Complexes in the Host Cell Nucleus	0.147093266081534	-1.91668843025036	2	2	0.000635727908455181	3146	8202	3303,3304	HSPA1A,HSPA1B
R-HSA-168268	Virus Assembly and Release	0.147093266081534	-1.91668843025036	2	2	0.000635727908455181	3146	8202	811,821	CALR,CANX
R-HSA-1483101	Synthesis of PS	0.147093266081534	-1.91668843025036	2	2	0.000635727908455181	3146	8202	81490,9791	PTDSS2,PTDSS1
R-HSA-211728	Regulation of PAK-2p34 activity by PS-GAP/RHG10	0.147093266081534	-1.91668843025036	2	2	0.000635727908455181	3146	8202	79658,5062	ARHGAP10,PAK2
R-HSA-141424	Amplification of signal from the kinetochores	0.147093266081534	-1.91668843025036	2	2	0.000635727908455181	3146	8202	4085,8379	MAD2L1,MAD1L1
R-HSA-141444	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal	0.147093266081534	-1.91668843025036	2	2	0.000635727908455181	3146	8202	4085,8379	MAD2L1,MAD1L1
R-HSA-168316	Assembly of Viral Components at the Budding Site	0.147093266081534	-1.91668843025036	2	2	0.000635727908455181	3146	8202	811,821	CALR,CANX
R-HSA-198765	Signalling to ERK5	0.147093266081534	-1.91668843025036	2	2	0.000635727908455181	3146	8202	5607,5598	MAP2K5,MAPK7
R-HSA-70688	Proline catabolism	0.147093266081534	-1.91668843025036	2	2	0.000635727908455181	3146	8202	8659,5625	ALDH4A1,PRODH
R-HSA-211736	Stimulation of the cell death response by PAK-2p34	0.147093266081534	-1.91668843025036	2	2	0.000635727908455181	3146	8202	836,5062	CASP3,PAK2
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	0.148247056810358	-1.9088750941826	47	22	0.00699300699300699	3146	8202	7128,330,257397,83737,3326,842,1147,7335,598,329,837,24145,10910,10392,23118,5608,3551,10628,835,841,10454,7334	TNFAIP3,BIRC3,TAB3,ITCH,HSP90AB1,CASP9,CHUK,UBE2V1,BCL2L1,BIRC2,CASP4,PANX1,SUGT1,NOD1,TAB2,MAP2K6,IKBKB,TXNIP,CASP2,CASP8,TAB1,UBE2N
R-HSA-416550	Sema4D mediated inhibition of cell attachment and migration	0.149164157856775	-1.90270784891404	8	5	0.00158931977113795	3146	8202	387,6237,5364,5879,27289	RHOA,RRAS,PLXNB1,RAC1,RND1
R-HSA-450520	HuR (ELAVL1) binds and stabilizes mRNA	0.149164157856775	-1.90270784891404	8	5	0.00158931977113795	3146	8202	8125,7514,1994,8021,6418	ANP32A,XPO1,ELAVL1,NUP214,SET
R-HSA-73928	Depyrimidination	0.149164157856775	-1.90270784891404	8	5	0.00158931977113795	3146	8202	23583,79661,6996,252969,7374	SMUG1,NEIL1,TDG,NEIL2,UNG
R-HSA-110329	Cleavage of the damaged pyrimidine	0.149164157856775	-1.90270784891404	8	5	0.00158931977113795	3146	8202	23583,79661,6996,252969,7374	SMUG1,NEIL1,TDG,NEIL2,UNG
R-HSA-5603027	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	0.149164157856775	-1.90270784891404	8	5	0.00158931977113795	3146	8202	1147,4793,4791,5970,3551	CHUK,NFKBIB,NFKB2,RELA,IKBKB
R-HSA-2046105	Linoleic acid (LA) metabolism	0.149164157856775	-1.90270784891404	8	5	0.00158931977113795	3146	8202	215,60481,2180,64834,83401	ABCD1,ELOVL5,ACSL1,ELOVL1,ELOVL3
R-HSA-163765	ChREBP activates metabolic gene expression	0.149164157856775	-1.90270784891404	8	5	0.00158931977113795	3146	8202	51085,6945,31,10554,2194	MLXIPL,MLX,ACACA,AGPAT1,FASN
R-HSA-193634	Axonal growth inhibition (RHOA activation)	0.149164157856775	-1.90270784891404	8	5	0.00158931977113795	3146	8202	57142,387,9138,84894,396	RTN4,RHOA,ARHGEF1,LINGO1,ARHGDIA
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected pyrimidine	0.149164157856775	-1.90270784891404	8	5	0.00158931977113795	3146	8202	23583,79661,6996,252969,7374	SMUG1,NEIL1,TDG,NEIL2,UNG
R-HSA-983189	Kinesins	0.153689409438991	-1.87282153491705	26	13	0.00413223140495868	3146	8202	3833,3799,3796,81930,10112,89953,56992,3831,11127,3835,64147,11004,3832	KIFC1,KIF5B,KIF2A,KIF18A,KIF20A,KLC4,KIF15,KLC1,KIF3A,KIF22,KIF9,KIF2C,KIF11
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	0.15399802747775	-1.87081548523658	33	16	0.00508582326764145	3146	8202	5438,5436,5441,2034,5440,57167,5433,5087,5430,5432,4087,9314,5434,84891,6774,4089	POLR2I,POLR2G,POLR2L,EPAS1,POLR2K,SALL4,POLR2D,PBX1,POLR2A,POLR2C,SMAD2,KLF4,POLR2E,ZSCAN10,STAT3,SMAD4
R-HSA-446219	Synthesis of substrates in N-glycan biosythesis	0.154615030318993	-1.86681692686238	52	24	0.00762873490146217	3146	8202	2673,9945,4351,64841,8813,10825,6480,10020,54344,256435,26503,10610,5373,29926,6487,5372,8818,79947,6484,22845,5238,29925,2720,6482	GFPT1,GFPT2,MPI,GNPNAT1,DPM1,NEU3,ST6GAL1,GNE,DPM3,ST6GALNAC3,SLC17A5,ST6GALNAC2,PMM2,GMPPA,ST3GAL3,PMM1,DPM2,DHDDS,ST3GAL4,DOLK,PGM3,GMPPB,GLB1,ST3GAL1
R-HSA-5336415	Uptake and function of diphtheria toxin	0.157179685093644	-1.85036563702211	6	4	0.00127145581691036	3146	8202	7296,3320,1938,3326	TXNRD1,HSP90AA1,EEF2,HSP90AB1
R-HSA-1482798	Acyl chain remodeling of CL	0.157179685093644	-1.85036563702211	6	4	0.00127145581691036	3146	8202	6901,253558,8398,3032	TAZ,LCLAT1,PLA2G6,HADHB
R-HSA-1237112	Methionine salvage pathway	0.157179685093644	-1.85036563702211	6	4	0.00127145581691036	3146	8202	58478,51074,84245,4507	ENOPH1,APIP,MRI1,MTAP
R-HSA-205025	NADE modulates death signalling	0.157179685093644	-1.85036563702211	6	4	0.00127145581691036	3146	8202	836,7531,27018,835	CASP3,YWHAE,NGFRAP1,CASP2
R-HSA-73942	DNA Damage Reversal	0.157179685093644	-1.85036563702211	6	4	0.00127145581691036	3146	8202	10973,51008,84164,4255	ASCC3,ASCC1,ASCC2,MGMT
R-HSA-444257	RSK activation	0.157179685093644	-1.85036563702211	6	4	0.00127145581691036	3146	8202	5170,6196,5594,6197	PDPK1,RPS6KA2,MAPK1,RPS6KA3
R-HSA-3000484	Scavenging by Class F Receptors	0.157179685093644	-1.85036563702211	6	4	0.00127145581691036	3146	8202	10525,811,10808,3320	HYOU1,CALR,HSPH1,HSP90AA1
R-HSA-5579026	Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	0.160732443990454	-1.82801413495174	4	3	0.000953591862682772	3146	8202	112812,2230,2232	FDX1L,FDX1,FDXR
R-HSA-1855191	Synthesis of IPs in the nucleus	0.160732443990454	-1.82801413495174	4	3	0.000953591862682772	3146	8202	64768,9807,253430	IPPK,IP6K1,IPMK
R-HSA-389599	Alpha-oxidation of phytanate	0.160732443990454	-1.82801413495174	4	3	0.000953591862682772	3146	8202	11001,5264,10478	SLC27A2,PHYH,SLC25A17
R-HSA-112126	ALKBH3 mediated reversal of alkylation damage	0.160732443990454	-1.82801413495174	4	3	0.000953591862682772	3146	8202	10973,51008,84164	ASCC3,ASCC1,ASCC2
R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	0.161323188666957	-1.82434554307414	17	9	0.00286077558804832	3146	8202	23404,118460,23016,207,51010,56915,5393,54512,54464	EXOSC2,EXOSC6,EXOSC7,AKT1,EXOSC3,EXOSC5,EXOSC9,EXOSC4,XRN1
R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	0.161323188666957	-1.82434554307414	17	9	0.00286077558804832	3146	8202	23404,118460,23016,51010,56915,5393,54512,54464,3842	EXOSC2,EXOSC6,EXOSC7,EXOSC3,EXOSC5,EXOSC9,EXOSC4,XRN1,TNPO1
R-HSA-1483206	Glycerophospholipid biosynthesis	0.161599276375344	-1.82263561078051	96	42	0.0133502860775588	3146	8202	8760,84803,55500,10554,162466,56894,81579,10162,11145,64900,10423,253558,8895,2819,1119,55326,23446,3032,57153,81490,5833,8694,79888,23171,8398,8904,85465,56895,50640,6901,79143,137964,10400,8443,254531,84649,154141,57678,5337,129642,9791,5130	CDS2,GPAT3,ETNK1,AGPAT1,PHOSPHO1,AGPAT3,PLA2G12A,LPCAT3,PLA2G16,LPIN3,CDIPT,LCLAT1,CPNE3,GPD1,CHKA,AGPAT5,SLC44A1,HADHB,SLC44A2,PTDSS2,PCYT2,DGAT1,LPCAT1,GPD1L,PLA2G6,CPNE1,EPT1,AGPAT4,PNPLA8,TAZ,MBOAT7,GPAT4,PEMT,GNPAT,LPCAT4,DGAT2,MBOAT1,GPAM,PLD1,MBOAT2,PTDSS1,PCYT1A
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	0.167072832201493	-1.78932544067146	24	12	0.00381436745073109	3146	8202	466,6196,1845,4205,1846,5598,9252,5594,5528,5519,6197,5595	ATF1,RPS6KA2,DUSP3,MEF2A,DUSP4,MAPK7,RPS6KA5,MAPK1,PPP2R5D,PPP2R1B,RPS6KA3,MAPK3
R-HSA-933542	TRAF6 mediated NF-kB activation	0.167072832201493	-1.78932544067146	24	12	0.00381436745073109	3146	8202	3146,7706,7186,3551,1660,1147,84282,4791,4793,5970,64135,4214	HMGB1,TRIM25,TRAF2,IKBKB,DHX9,CHUK,RNF135,NFKB2,NFKBIB,RELA,IFIH1,MAP3K1
R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.175992290113327	-1.73731509107778	15	8	0.00254291163382072	3146	8202	2885,5335,6464,6654,5295,3320,2549,3265	GRB2,PLCG1,SHC1,SOS1,PIK3R1,HSP90AA1,GAB1,HRAS
R-HSA-5358508	Mismatch Repair	0.175992290113327	-1.73731509107778	15	8	0.00254291163382072	3146	8202	9156,5111,4437,3978,5424,10714,5425,2956	EXO1,PCNA,MSH3,LIG1,POLD1,POLD3,POLD2,MSH6
R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.175992290113327	-1.73731509107778	15	8	0.00254291163382072	3146	8202	2885,5335,6464,6654,5295,3320,2549,3265	GRB2,PLCG1,SHC1,SOS1,PIK3R1,HSP90AA1,GAB1,HRAS
R-HSA-73728	RNA Polymerase I Promoter Opening	0.176105480518635	-1.73667214233656	60	27	0.00858232676414495	3146	8202	8352,8968,3015,8367,8358,8350,8368,8357,8360,5595,8365,121504,8294,7343,3012,8334,8366,8932,8364,8351,3014,653604,8345,3020,8338,8331,8354	HIST1H3C,HIST1H3F,H2AFZ,HIST1H4E,HIST1H3B,HIST1H3A,HIST1H4L,HIST1H3H,HIST1H4D,MAPK3,HIST1H4H,HIST4H4,HIST1H4I,UBTF,HIST1H2AE,HIST1H2AC,HIST1H4B,MBD2,HIST1H4C,HIST1H3D,H2AFX,HIST2H3D,HIST1H2BH,H3F3A,HIST2H2AC,HIST1H2AJ,HIST1H3I
R-HSA-5655302	Signaling by FGFR1 in disease	0.177110910914012	-1.73097912731632	36	17	0.00540368722186904	3146	8202	11116,8805,6654,5295,1523,6777,2260,2885,5335,399687,6776,6774,11052,2549,10818,3265,26127	FGFR1OP,TRIM24,SOS1,PIK3R1,CUX1,STAT5B,FGFR1,GRB2,PLCG1,MYO18A,STAT5A,STAT3,CPSF6,GAB1,FRS2,HRAS,FGFR1OP2
R-HSA-2172127	DAP12 interactions	0.178275848955912	-1.72442321502099	340	139	0.0441830896376351	3146	8202	7249,4763,5786,5720,1026,3709,5519,5906,5696,5688,5296,5701,10818,5567,64223,7311,9978,208,842,283455,5335,5719,6233,4296,4254,5690,5527,2932,5705,409,5528,5700,2549,5689,5693,5245,7410,8649,5713,814,808,10256,5715,1847,5581,5686,5702,8437,5908,5685,5605,5691,5921,5704,3708,2069,192669,161742,200734,685,10142,9462,5683,2475,5894,8826,5879,5037,5604,2064,1147,5566,5687,4193,6464,6711,115,23198,10213,8503,1027,253260,10768,7414,207,2931,5695,8452,1742,1846,3710,2260,8660,817,5529,2534,5706,80824,5709,5536,9861,4343,5594,5711,1844,23112,673,79109,5716,567,9491,2309,5708,117145,5781,3717,5717,2065,7314,6199,1843,6709,5694,5170,5692,4303,6654,3164,5295,5747,5710,7316,5595,2885,57761,84078,152559,84292,3265	TSC2,NF1,PTPRA,PSME1,CDKN1A,ITPR2,PPP2R1B,RAP1A,PSMB8,PSMA7,PIK3R2,PSMC2,FRS2,PRKACB,MLST8,UBA52,RBX1,AKT2,CASP9,KSR2,PLCG1,PSMD13,RPS27A,MAP3K11,KITLG,PSMB2,PPP2R5C,GSK3B,PSMC5,ARRB2,PPP2R5D,PSMC1,GAB1,PSMB1,PSMB5,PHB,VAV2,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PSMD9,DUSP5,PRKCE,PSMA5,PSMC3,RASAL1,RAP1B,PSMA4,MAP2K2,PSMB3,RASA1,PSMC4,ITPR1,EREG,AGO3,SPRED1,SPRED2,BTC,AKAP9,RASAL2,PSMA2,MTOR,RAF1,IQGAP1,RAC1,PEBP1,MAP2K1,ERBB2,CHUK,PRKACA,PSMA6,MDM2,SHC1,SPTBN1,ADCY9,PSME4,PSMD14,PIK3R3,CDKN1B,RICTOR,AHCYL1,VCL,AKT1,GSK3A,PSMB7,CUL3,DLG4,DUSP4,ITPR3,FGFR1,IRS2,CAMK2D,PPP2R5E,FYN,PSMC6,DUSP16,PSMD3,PPP5C,PSMD6,MOV10,MAPK1,PSMD5,DUSP2,TNRC6B,BRAF,MAPKAP1,PSMD10,B2M,PSMF1,FOXO3,PSMD2,THEM4,PTPN11,JAK2,PSMD11,ERBB3,UBB,RPS6KB2,DUSP1,SPTAN1,PSMB6,PDPK1,PSMB4,FOXO4,SOS1,NR4A1,PIK3R1,PTK2,PSMD4,UBC,MAPK3,GRB2,TRIB3,KBTBD7,PAQR3,WDR83,HRAS
R-HSA-194840	Rho GTPase cycle	0.178791228923115	-1.72153647268582	124	53	0.0168467895740623	3146	8202	23092,391,50650,64411,9886,91614,10928,389,58504,7410,5879,7204,4983,10144,5881,84144,57449,4952,5296,57522,9181,392,9828,9754,57514,6453,89839,55114,6655,23433,55789,387,6654,10276,23526,80728,84033,23365,11214,55288,388,116985,171177,396,94134,9411,4649,90627,57636,23229,79658,64857,2245	ARHGAP26,RHOG,ARHGEF3,ARAP3,RHOBTB1,DEPDC7,RALBP1,RHOC,ARHGAP22,VAV2,RAC1,TRIO,OPHN1,FAM13A,RAC3,SYDE2,PLEKHG5,OCRL,PIK3R2,SRGAP1,ARHGEF2,ARHGAP1,ARHGEF17,STARD8,ARHGAP31,ITSN1,ARHGAP11B,ARHGAP17,SOS2,RHOQ,DEPDC1B,RHOA,SOS1,NET1,HMHA1,ARHGAP39,OBSCN,ARHGEF12,AKAP13,RHOT1,RHOB,ARAP1,RHOV,ARHGDIA,ARHGAP12,ARHGAP29,MYO9A,STARD13,ARHGAP23,ARHGEF9,ARHGAP10,PLEKHG2,FGD1
R-HSA-1912408	Pre-NOTCH Transcription and Translation	0.181000489862505	-1.70925554129729	29	14	0.00445009535918627	3146	8202	2033,1387,23112,22938,2648,10046,7027,1871,3516,7029,9794,4343,192669,55534	EP300,CREBBP,TNRC6B,SNW1,KAT2A,MAMLD1,TFDP1,E2F3,RBPJ,TFDP2,MAML1,MOV10,AGO3,MAML3
R-HSA-5339562	Uptake and actions of bacterial toxins	0.181000489862505	-1.70925554129729	29	14	0.00445009535918627	3146	8202	7296,1938,5609,5608,3326,5045,5604,808,6616,3320,6857,5605,6416,5606	TXNRD1,EEF2,MAP2K7,MAP2K6,HSP90AB1,FURIN,MAP2K1,CALM3,SNAP25,HSP90AA1,SYT1,MAP2K2,MAP2K4,MAP2K3
R-HSA-917977	Transferrin endocytosis and recycling	0.181000489862505	-1.70925554129729	29	14	0.00445009535918627	3146	8202	51382,10312,523,537,535,23545,527,51606,528,529,9114,8992,7037,9550	ATP6V1D,TCIRG1,ATP6V1A,ATP6AP1,ATP6V0A1,ATP6V0A2,ATP6V0C,ATP6V1H,ATP6V1C1,ATP6V1E1,ATP6V0D1,ATP6V0E1,TFRC,ATP6V1G1
R-HSA-389513	CTLA4 inhibitory signaling	0.181975871933222	-1.70388117248924	22	11	0.0034965034965035	3146	8202	5170,5529,2534,207,208,5781,5527,7525,4067,5528,5519	PDPK1,PPP2R5E,FYN,AKT1,AKT2,PTPN11,PPP2R5C,YES1,LYN,PPP2R5D,PPP2R1B
R-HSA-556833	Metabolism of lipids and lipoproteins	0.182063269864243	-1.70340101570023	628	252	0.0801017164653528	3146	8202	1591,2180,5565,54677,6256,91012,10554,162466,11145,10423,25942,6382,64834,8898,1632,1387,1490,6721,55326,5034,3291,5296,23446,3032,7004,231,4199,5901,5499,9524,5360,55588,5567,31,10498,8463,1545,80205,5468,8612,10087,9200,10413,25870,857,3417,79143,641371,9969,137964,23590,51170,2531,4047,3638,112812,211,2717,9282,10891,8720,10005,2170,127281,3636,9871,84803,51003,30849,427,81579,6319,2819,1119,112950,84246,5298,6307,4952,81490,9968,9217,5833,9443,200576,8694,6309,79888,51805,224,4801,10478,2222,3156,23309,91289,85465,11001,65985,79071,50814,2181,8841,6916,2629,2194,2274,6342,6604,7108,3295,8394,9517,55697,55361,3931,8202,8396,51422,201562,8443,2224,51586,254531,84649,9440,6907,5337,9611,2101,3073,1717,9791,2033,9374,7357,10858,55500,1375,10162,22949,64900,5566,253558,9453,29079,8895,51302,2230,4899,8611,3422,23054,9441,9110,377,8503,2182,23171,84188,2879,84693,10802,8904,10484,84274,57704,10025,6901,5743,221,22937,23097,253782,80724,10400,406,25937,5500,22908,154141,113612,5007,9575,129642,56848,9412,2710,8760,10825,8877,56894,285362,5297,375,30,10654,3930,5501,10682,3157,81857,4520,9632,1384,2232,117145,57153,215,3155,10728,9896,5469,8398,3837,6837,6576,51360,55856,6667,7296,60481,5096,1024,7003,56895,5295,83401,5465,1892,55331,50640,166785,5264,10427,51128,5467,57761,51,80765,8560,4802,38,64788,2720,57678,64801,2876,8310,9536,5130,11332	CYP24A1,ACSL1,PRKAB2,CROT,RXRA,CERS5,AGPAT1,PHOSPHO1,PLA2G16,CDIPT,SIN3A,SDC1,ELOVL1,MTMR2,ECI1,CREBBP,CTGF,SREBF2,AGPAT5,P4HB,HSD11B2,PIK3R2,SLC44A1,HADHB,TEAD4,AKR1B1,ME1,RAN,PPP1CA,TECR,PLTP,MED29,PRKACB,ACACA,CARM1,TEAD2,CYP1B1,CHD9,PPARG,PLPP2,COL4A3BP,HACD1,YAP1,SUMF2,CAV1,IDH1,MBOAT7,ACOT1,MED13,GPAT4,PDSS1,HSD17B11,KDSR,LSS,INSIG1,FDX1L,ALAS1,GLA,MED14,PPARGC1A,MBTPS1,ACOT8,FABP3,FAM213B,INPPL1,SEC24D,GPAT3,MED31,PIK3R4,ASAH1,PLA2G12A,SCD,GPD1,CHKA,MED8,MED10,PI4KB,MSMO1,OCRL,PTDSS2,MED12,VAPB,PCYT2,MED7,PIKFYVE,DGAT1,SC5D,LPCAT1,COQ3,ALDH3A2,NFYB,SLC25A17,FDFT1,HMGCR,SIN3B,LMF2,EPT1,SLC27A2,AACS,ELOVL6,NSDHL,ACSL3,HDAC3,TBXAS1,GBA,FASN,FHL2,SCP2,SMARCD3,TM7SF2,HSD17B4,PIP5K1A,SPTLC2,VAC14,PI4K2A,LCAT,NCOA3,PIP4K2B,PRKAG2,HACD2,GNPAT,FDPS,MED15,LPCAT4,DGAT2,MED17,TBL1X,PLD1,NCOR1,ESRRA,HEXA,DHCR7,PTDSS1,EP300,PPT2,UGCG,CYP46A1,ETNK1,CPT1B,LPCAT3,PTGR1,LPIN3,PRKACA,LCLAT1,GGPS1,MED4,CPNE3,CYP39A1,FDX1,NRF1,PLPP1,IDI1,NCOA6,MED26,MTMR4,ARF3,PIK3R3,ACSL4,GPD1L,FAR1,GPX4,MCEE,SEC24A,CPNE1,SEC23A,COQ5,GBA2,MED16,TAZ,PTGS2,ALDH3B1,SCAP,CDK19,CERS6,ACAD10,PEMT,ARNTL,WWTR1,PPP1CB,SACM1L,MBOAT1,CYP2U1,OSBP,CLOCK,MBOAT2,SPHK2,MED21,GK,CDS2,NEU3,SPHK1,AGPAT3,SUMF1,PI4KA,ARF1,ACAA1,PMVK,LBR,PPP1CC,EBP,HMGCS1,MED25,MTF1,SEC24C,CRAT,FDXR,THEM4,SLC44A2,ABCD1,HMGCL,PTGES3,FIG4,MED1,PLA2G6,KPNB1,MED22,SLC25A1,MBTPS2,ACOT13,SP1,TXNRD1,ELOVL5,PCCB,CDK8,TEAD1,AGPAT4,PIK3R1,ELOVL3,PPARA,ECHS1,ACER3,PNPLA8,MMAA,PHYH,SEC24B,SAR1B,PPARD,TRIB3,ACOX1,STARD5,DEGS1,NFYC,ACAT1,LMF1,GLB1,GPAM,ARV1,GPX1,ACOX3,PTGES,PCYT1A,ACOT7
R-HSA-212300	PRC2 methylates histones and DNA	0.183310190572753	-1.69657553063135	70	31	0.00985378258105531	3146	8202	8352,8968,3015,121536,5931,8367,26147,23512,8358,8350,8368,8357,5252,8360,8365,121504,2146,8294,3012,8334,8366,8351,8364,3014,653604,8345,3020,8338,22823,8331,8354	HIST1H3C,HIST1H3F,H2AFZ,AEBP2,RBBP7,HIST1H4E,PHF19,SUZ12,HIST1H3B,HIST1H3A,HIST1H4L,HIST1H3H,PHF1,HIST1H4D,HIST1H4H,HIST4H4,EZH2,HIST1H4I,HIST1H2AE,HIST1H2AC,HIST1H4B,HIST1H3D,HIST1H4C,H2AFX,HIST2H3D,HIST1H2BH,H3F3A,HIST2H2AC,MTF2,HIST1H2AJ,HIST1H3I
R-HSA-2132295	MHC class II antigen presentation	0.184541708325532	-1.68987977966458	102	44	0.013986013986014	3146	8202	11258,1781,6396,10120,1173,26052,9871,8722,8655,89953,3831,11004,375,821,3799,1075,9632,51164,8907,1785,163,3835,79659,130340,10802,10484,83547,10112,7879,8905,56992,3832,51128,10671,22872,3796,10427,81930,160,1213,11127,164,1175,1783	DCTN3,DYNC1I2,SEC13,ACTR1B,AP2M1,DNM3,SEC24D,CTSF,DYNLL1,KLC4,KLC1,KIF2C,ARF1,CANX,KIF5B,CTSC,SEC24C,DCTN4,AP1M1,DNM2,AP2B1,KIF22,DYNC2H1,AP1S3,SEC24A,SEC23A,RILP,KIF20A,RAB7A,AP1S2,KIF15,KIF11,SAR1B,DCTN6,SEC31A,KIF2A,SEC24B,KIF18A,AP2A1,CLTC,KIF3A,AP1G1,AP2S1,DYNC1LI2
R-HSA-70153	Glucose transport	0.185276331665833	-1.68590688366099	41	19	0.00603941513032422	3146	8202	6517,23511,8480,9631,348995,92579,8021,9883,23165,129401,7175,5903,57122,23636,9972,3098,3101,79902,81929	SLC2A4,NUP188,RAE1,NUP155,NUP43,G6PC3,NUP214,POM121,NUP205,NUP35,TPR,RANBP2,NUP107,NUP62,NUP153,HK1,HK3,NUP85,SEH1L
R-HSA-196854	Metabolism of vitamins and cofactors	0.19234373142894	-1.64847123971472	90	39	0.012396694214876	3146	8202	80025,55034,25974,79717,56922,10560,4552,80308,60496,2356,55229,6472,326625,31,4522,1727,55163,5096,64802,8034,51248,53354,2194,55788,25902,93100,166785,1528,27010,5743,119391,5091,1719,200895,8566,79646,9054,686,65220	PANK2,MOCOS,MMACHC,PPCS,MCCC1,SLC19A2,MTRR,FLAD1,AASDHPPT,FPGS,PANK4,SHMT2,MMAB,ACACA,MTHFD1,CYB5R3,PNPO,PCCB,NMNAT1,SLC25A16,PDZD11,PANK1,FASN,LMBRD1,MTHFD1L,NAPRT,MMAA,CYB5A,TPK1,PTGS2,GSTO2,PC,DHFR,DHFRL1,PDXK,PANK3,NFS1,BTD,NADK
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	0.19234373142894	-1.64847123971472	90	39	0.012396694214876	3146	8202	80025,55034,25974,79717,56922,10560,4552,80308,60496,2356,55229,6472,326625,31,4522,1727,55163,5096,64802,8034,51248,53354,2194,55788,25902,93100,166785,1528,27010,5743,119391,5091,1719,200895,8566,79646,9054,686,65220	PANK2,MOCOS,MMACHC,PPCS,MCCC1,SLC19A2,MTRR,FLAD1,AASDHPPT,FPGS,PANK4,SHMT2,MMAB,ACACA,MTHFD1,CYB5R3,PNPO,PCCB,NMNAT1,SLC25A16,PDZD11,PANK1,FASN,LMBRD1,MTHFD1L,NAPRT,MMAA,CYB5A,TPK1,PTGS2,GSTO2,PC,DHFR,DHFRL1,PDXK,PANK3,NFS1,BTD,NADK
R-HSA-209560	NF-kB is activated and signals survival	0.192533683446484	-1.64748416161856	13	7	0.00222504767959313	3146	8202	7311,8878,7314,5970,6233,7316,3551	UBA52,SQSTM1,UBB,RELA,RPS27A,UBC,IKBKB
R-HSA-211227	Activation of DNA fragmentation factor	0.192533683446484	-1.64748416161856	13	7	0.00222504767959313	3146	8202	836,3148,3146,3008,1676,3837,3009	CASP3,HMGB2,HMGB1,HIST1H1E,DFFA,KPNB1,HIST1H1B
R-HSA-350054	Notch-HLH transcription pathway	0.192533683446484	-1.64748416161856	13	7	0.00222504767959313	3146	8202	1387,22938,3516,9794,2648,10046,55534	CREBBP,SNW1,RBPJ,MAML1,KAT2A,MAMLD1,MAML3
R-HSA-3270619	IRF3-mediated induction of type I IFN	0.192533683446484	-1.64748416161856	13	7	0.00222504767959313	3146	8202	4361,3661,29110,51428,5591,23220,7520	MRE11A,IRF3,TBK1,DDX41,PRKDC,DTX4,XRCC5
R-HSA-74217	Purine salvage	0.192533683446484	-1.64748416161856	13	7	0.00222504767959313	3146	8202	271,51292,353,3251,4860,132,1633	AMPD2,GMPR2,APRT,HPRT1,PNP,ADK,DCK
R-HSA-209543	p75NTR recruits signalling complexes	0.192533683446484	-1.64748416161856	13	7	0.00222504767959313	3146	8202	7311,8878,7314,6233,7316,3551,5584	UBA52,SQSTM1,UBB,RPS27A,UBC,IKBKB,PRKCI
R-HSA-140342	Apoptosis induced DNA fragmentation	0.192533683446484	-1.64748416161856	13	7	0.00222504767959313	3146	8202	836,3148,3146,3008,1676,3837,3009	CASP3,HMGB2,HMGB1,HIST1H1E,DFFA,KPNB1,HIST1H1B
R-HSA-1660516	Synthesis of PIPs at the early endosome membrane	0.192533683446484	-1.64748416161856	13	7	0.00222504767959313	3146	8202	9896,200576,8898,9110,55697,55361,30849	FIG4,PIKFYVE,MTMR2,MTMR4,VAC14,PI4K2A,PIK3R4
R-HSA-5626467	RHO GTPases activate IQGAPs	0.192533683446484	-1.64748416161856	13	7	0.00222504767959313	3146	8202	808,6249,1499,4221,1495,8826,5879	CALM3,CLIP1,CTNNB1,MEN1,CTNNA1,IQGAP1,RAC1
R-HSA-4641265	Repression of WNT target genes	0.192533683446484	-1.64748416161856	13	7	0.00222504767959313	3146	8202	7091,3065,1488,1499,7090,1487,6934	TLE4,HDAC1,CTBP2,CTNNB1,TLE3,CTBP1,TCF7L2
R-HSA-391160	Signal regulatory protein (SIRP) family interactions	0.192533683446484	-1.64748416161856	13	7	0.00222504767959313	3146	8202	2885,2185,5747,8935,5777,961,5781	GRB2,PTK2B,PTK2,SKAP2,PTPN6,CD47,PTPN11
R-HSA-177504	Retrograde neurotrophin signalling	0.192533683446484	-1.64748416161856	13	7	0.00222504767959313	3146	8202	163,26052,1173,1175,160,10126,1785	AP2B1,DNM3,AP2M1,AP2S1,AP2A1,DNAL4,DNM2
R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation	0.192533683446484	-1.64748416161856	13	7	0.00222504767959313	3146	8202	808,5532,3709,3710,10768,3708,5534	CALM3,PPP3CB,ITPR2,ITPR3,AHCYL1,ITPR1,PPP3R1
R-HSA-1280215	Cytokine Signaling in Immune system	0.210777531772721	-1.55695205351397	539	216	0.0686586141131596	3146	8202	23291,23321,23511,4763,85363,5786,8454,3606,6777,5720,329,5519,5906,5696,9775,5688,3572,5296,51135,5701,3660,9972,3459,1977,3556,10818,81929,25820,7311,3841,9978,11274,283455,7335,5335,1981,1398,5719,6233,25970,80263,4296,684,4254,2185,5690,5527,3838,5705,409,5528,5700,80128,5689,3636,5693,1958,9039,5245,8649,5713,808,10256,5715,1847,23165,8519,129401,1154,9246,8878,970,51330,79902,5686,1974,5702,8437,5908,1982,5685,5605,9636,5691,5921,7324,3663,5704,2069,23636,7534,6416,2537,3659,10142,161742,200734,685,9462,5683,8826,5894,5037,8835,5604,2064,1147,3661,348995,5495,4067,5566,1399,5610,5687,6464,8651,6672,7706,6711,3551,23198,10213,57122,8503,103,4940,4791,5970,7414,4215,4599,330,115650,5777,5695,8452,1742,9631,1846,958,8021,7297,6773,2260,9021,8660,5903,817,5529,2534,53840,3839,23118,5706,80824,5709,5536,9861,10454,79155,5594,7334,5711,1844,673,257397,7186,8480,5716,51191,3430,8672,567,9491,3105,9883,7341,5708,25939,5781,10612,6737,3717,5717,2065,9020,7314,6774,3837,1843,5694,6709,6868,5692,6654,5295,23087,5747,7525,3454,5710,7316,5595,2885,7175,3840,7726,10392,5608,3569,84078,152559,6776,84292,3265	FBXW11,TRIM2,NUP188,NF1,TRIM5,PTPRA,CUL1,IL18,STAT5B,PSME1,BIRC2,PPP2R1B,RAP1A,PSMB8,EIF4A3,PSMA7,IL6ST,PIK3R2,IRAK4,PSMC2,IRF2,NUP153,IFNGR1,EIF4E,IL1RAP,FRS2,SEH1L,ARIH1,UBA52,KPNA5,RBX1,USP18,KSR2,UBE2V1,PLCG1,EIF4G1,CRK,PSMD13,RPS27A,SH2B1,TRIM45,MAP3K11,BST2,KITLG,PTK2B,PSMB2,PPP2R5C,KPNA2,PSMC5,ARRB2,PPP2R5D,PSMC1,TRIM46,PSMB1,INPPL1,PSMB5,EGR1,UBA3,PHB,LAMTOR3,PSMD7,CALM3,CNKSR1,PSMD9,DUSP5,NUP205,IFITM1,NUP35,CISH,UBE2L6,SQSTM1,CD70,TNFRSF12A,NUP85,PSMA5,EIF4A2,PSMC3,RASAL1,RAP1B,EIF4G2,PSMA4,MAP2K2,ISG15,PSMB3,RASA1,UBE2E1,IRF5,PSMC4,EREG,NUP62,YWHAZ,MAP2K4,IFI6,IRF1,AKAP9,SPRED1,SPRED2,BTC,RASAL2,PSMA2,IQGAP1,RAF1,PEBP1,SOCS2,MAP2K1,ERBB2,CHUK,IRF3,NUP43,PPM1B,LYN,PRKACA,CRKL,EIF2AK2,PSMA6,SHC1,SOCS1,SP100,TRIM25,SPTBN1,IKBKB,PSME4,PSMD14,NUP107,PIK3R3,ADAR,OAS3,NFKB2,RELA,VCL,MAP3K3,MX1,BIRC3,TNFRSF13C,PTPN6,PSMB7,CUL3,DLG4,NUP155,DUSP4,CD40,NUP214,TYK2,STAT2,FGFR1,SOCS3,IRS2,RANBP2,CAMK2D,PPP2R5E,FYN,TRIM34,KPNA3,TAB2,PSMC6,DUSP16,PSMD3,PPP5C,PSMD6,TAB1,TNIP2,MAPK1,UBE2N,PSMD5,DUSP2,BRAF,TAB3,TRAF2,RAE1,PSMD10,HERC5,IFI35,EIF4G3,B2M,PSMF1,HLA-A,POM121,SUMO1,PSMD2,SAMHD1,PTPN11,TRIM3,TRIM21,JAK2,PSMD11,ERBB3,MAP3K14,UBB,STAT3,KPNB1,DUSP1,PSMB6,SPTAN1,ADAM17,PSMB4,SOS1,PIK3R1,TRIM35,PTK2,YES1,IFNAR1,PSMD4,UBC,MAPK3,GRB2,TPR,KPNA4,TRIM26,NOD1,MAP2K6,IL6,KBTBD7,PAQR3,STAT5A,WDR83,HRAS
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	0.211365163715436	-1.5541680076046	11	6	0.00190718372536554	3146	8202	4926,121441,891,983,85378,114791	NUMA1,NEDD1,CCNB1,CDK1,TUBGCP6,TUBGCP5
R-HSA-5625970	RHO GTPases activate KTN1	0.211365163715436	-1.5541680076046	11	6	0.00190718372536554	3146	8202	3831,3799,391,387,5879,89953	KLC1,KIF5B,RHOG,RHOA,RAC1,KLC4
R-HSA-196780	Biotin transport and metabolism	0.211365163715436	-1.5541680076046	11	6	0.00190718372536554	3146	8202	5096,5091,51248,31,686,56922	PCCB,PC,PDZD11,ACACA,BTD,MCCC1
R-HSA-199983	Golgi to ER Retrograde Transport	0.211365163715436	-1.5541680076046	11	6	0.00190718372536554	3146	8202	375,8729,1315,9276,22820,11316	ARF1,GBF1,COPB1,COPB2,COPG1,COPE
R-HSA-199997	COPI Mediated Transport	0.211365163715436	-1.5541680076046	11	6	0.00190718372536554	3146	8202	375,8729,1315,9276,22820,11316	ARF1,GBF1,COPB1,COPB2,COPG1,COPE
R-HSA-196757	Metabolism of folate and pterines	0.211365163715436	-1.5541680076046	11	6	0.00190718372536554	3146	8202	1719,6472,200895,25902,2356,4522	DHFR,SHMT2,DHFRL1,MTHFD1L,FPGS,MTHFD1
R-HSA-200425	Import of palmitoyl-CoA into the mitochondrial matrix	0.211365163715436	-1.5541680076046	11	6	0.00190718372536554	3146	8202	5467,1375,51422,5565,6256,31	PPARD,CPT1B,PRKAG2,PRKAB2,RXRA,ACACA
R-HSA-189451	Heme biosynthesis	0.211365163715436	-1.5541680076046	11	6	0.00190718372536554	3146	8202	7390,210,5498,1371,7389,211	UROS,ALAD,PPOX,CPOX,UROD,ALAS1
R-HSA-5673000	RAF activation	0.214056302401675	-1.54151620322887	25	12	0.00381436745073109	3146	8202	5529,673,5894,5245,5604,4296,5527,3717,5528,5605,3265,5519	PPP2R5E,BRAF,RAF1,PHB,MAP2K1,MAP3K11,PPP2R5C,JAK2,PPP2R5D,MAP2K2,HRAS,PPP2R1B
R-HSA-162588	Budding and maturation of HIV virion	0.214056302401675	-1.54151620322887	25	12	0.00381436745073109	3146	8202	7311,6233,51510,9525,7251,27183,25978,7314,55048,5478,7316,92421	UBA52,RPS27A,CHMP5,VPS4B,TSG101,VPS4A,CHMP2B,UBB,VPS37C,PPIA,UBC,CHMP4C
R-HSA-210991	Basigin interactions	0.214056302401675	-1.54151620322887	25	12	0.00381436745073109	3146	8202	6520,23657,23759,3688,9123,682,6566,482,857,481,5478,9057	SLC3A2,SLC7A11,PPIL2,ITGB1,SLC16A3,BSG,SLC16A1,ATP1B2,CAV1,ATP1B1,PPIA,SLC7A6
R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	0.217474532472596	-1.52567352738923	18	9	0.00286077558804832	3146	8202	29110,7311,6233,10010,5781,148022,3661,7314,7316	TBK1,UBA52,RPS27A,TANK,PTPN11,TICAM1,IRF3,UBB,UBC
R-HSA-912631	Regulation of signaling by CBL	0.217474532472596	-1.52567352738923	18	9	0.00286077558804832	3146	8202	2885,1399,2534,1398,5296,5295,8503,7525,4067	GRB2,CRKL,FYN,CRK,PIK3R2,PIK3R1,PIK3R3,YES1,LYN
R-HSA-1483257	Phospholipid metabolism	0.219118091489925	-1.51814446395058	146	61	0.019389701207883	3146	8202	3636,8760,84803,55500,10554,30849,162466,56894,81579,5297,10162,375,11145,64900,10423,8898,253558,8895,2819,1119,5298,55326,9110,4952,5296,23446,377,3032,57153,81490,8503,5833,9896,200576,8694,79888,23171,8398,8904,85465,56895,5295,50640,8394,6901,79143,55697,137964,55361,8396,10400,8443,254531,84649,22908,154141,5337,57678,129642,9791,5130	INPPL1,CDS2,GPAT3,ETNK1,AGPAT1,PIK3R4,PHOSPHO1,AGPAT3,PLA2G12A,PI4KA,LPCAT3,ARF1,PLA2G16,LPIN3,CDIPT,MTMR2,LCLAT1,CPNE3,GPD1,CHKA,PI4KB,AGPAT5,MTMR4,OCRL,PIK3R2,SLC44A1,ARF3,HADHB,SLC44A2,PTDSS2,PIK3R3,PCYT2,FIG4,PIKFYVE,DGAT1,LPCAT1,GPD1L,PLA2G6,CPNE1,EPT1,AGPAT4,PIK3R1,PNPLA8,PIP5K1A,TAZ,MBOAT7,VAC14,GPAT4,PI4K2A,PIP4K2B,PEMT,GNPAT,LPCAT4,DGAT2,SACM1L,MBOAT1,PLD1,GPAM,MBOAT2,PTDSS1,PCYT1A
R-HSA-379724	tRNA Aminoacylation	0.222105490687717	-1.50460282669567	42	19	0.00603941513032422	3146	8202	833,3735,124454,2617,23395,57505,10667,7407,16,80222,51067,2193,5917,92935,3376,55157,23438,7965,79587	CARS,KARS,EARS2,GARS,LARS2,AARS2,FARS2,VARS,AARS,TARS2,YARS2,FARSA,RARS,MARS2,IARS,DARS2,HARS2,AIMP2,CARS2
R-HSA-162592	Integration of provirus	0.23308159969519	-1.45636667344272	9	5	0.00158931977113795	3146	8202	3981,3159,11168,5478,7520	LIG4,HMGA1,PSIP1,PPIA,XRCC5
R-HSA-196108	Pregnenolone biosynthesis	0.23308159969519	-1.45636667344272	9	5	0.00158931977113795	3146	8202	231,112812,80765,2232,2230	AKR1B1,FDX1L,STARD5,FDXR,FDX1
R-HSA-428890	Role of Abl in Robo-Slit signaling	0.23308159969519	-1.45636667344272	9	5	0.00158931977113795	3146	8202	25,23122,10487,9353,6091	ABL1,CLASP2,CAP1,SLIT2,ROBO1
R-HSA-428543	Inactivation of Cdc42 and Rac	0.23308159969519	-1.45636667344272	9	5	0.00158931977113795	3146	8202	9353,5879,80728,57522,6091	SLIT2,RAC1,ARHGAP39,SRGAP1,ROBO1
R-HSA-1234158	Regulation of gene expression by Hypoxia-inducible Factor	0.23308159969519	-1.45636667344272	9	5	0.00158931977113795	3146	8202	2033,1387,7422,2034,3091	EP300,CREBBP,VEGFA,EPAS1,HIF1A
R-HSA-193697	p75NTR regulates axonogenesis	0.23308159969519	-1.45636667344272	9	5	0.00158931977113795	3146	8202	57142,387,9138,84894,396	RTN4,RHOA,ARHGEF1,LINGO1,ARHGDIA
R-HSA-139853	Elevation of cytosolic Ca2+ levels	0.23308159969519	-1.45636667344272	9	5	0.00158931977113795	3146	8202	84876,3709,3710,6786,3708	ORAI1,ITPR2,ITPR3,STIM1,ITPR1
R-HSA-3215018	Processing and activation of SUMO	0.23308159969519	-1.45636667344272	9	5	0.00158931977113795	3146	8202	10055,10054,205564,29843,7341	SAE1,UBA2,SENP5,SENP1,SUMO1
R-HSA-390450	Folding of actin by CCT/TriC	0.23308159969519	-1.45636667344272	9	5	0.00158931977113795	3146	8202	22948,7203,10576,60,6950	CCT5,CCT3,CCT2,ACTB,TCP1
R-HSA-5627123	RHO GTPases activate PAKs	0.233460400656339	-1.45474280659213	23	11	0.0034965034965035	3146	8202	10398,4659,3984,5062,5879,5500,4660,808,4637,2017,4628	MYL9,PPP1R12A,LIMK1,PAK2,RAC1,PPP1CB,PPP1R12B,CALM3,MYL6,CTTN,MYH10
R-HSA-937072	TRAF6 mediated induction of TAK1 complex	0.238862062084505	-1.43186903975348	16	8	0.00254291163382072	3146	8202	7311,23118,257397,6233,148022,7314,10454,7316	UBA52,TAB2,TAB3,RPS27A,TICAM1,UBB,TAB1,UBC
R-HSA-193639	p75NTR signals via NF-kB	0.238862062084505	-1.43186903975348	16	8	0.00254291163382072	3146	8202	7311,8878,6233,3551,5584,7314,5970,7316	UBA52,SQSTM1,RPS27A,IKBKB,PRKCI,UBB,RELA,UBC
R-HSA-1433559	Regulation of KIT signaling	0.238862062084505	-1.43186903975348	16	8	0.00254291163382072	3146	8202	2885,2534,8651,6654,5777,4254,7525,4067	GRB2,FYN,SOCS1,SOS1,PTPN6,KITLG,YES1,LYN
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1	0.238862062084505	-1.43186903975348	16	8	0.00254291163382072	3146	8202	5599,10392,5609,23118,257397,5601,10454,6416	MAPK8,NOD1,MAP2K7,TAB2,TAB3,MAPK9,TAB1,MAP2K4
R-HSA-2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	0.238862062084505	-1.43186903975348	16	8	0.00254291163382072	3146	8202	50848,7311,387,7314,57154,6233,7316,5590	F11R,UBA52,RHOA,UBB,SMURF1,RPS27A,UBC,PRKCZ
R-HSA-399954	Sema3A PAK dependent Axon repulsion	0.238862062084505	-1.43186903975348	16	8	0.00254291163382072	3146	8202	2534,3984,3326,5062,5879,3320,8829,2242	FYN,LIMK1,HSP90AB1,PAK2,RAC1,HSP90AA1,NRP1,FES
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	0.254855886902312	-1.36705704298353	70	30	0.00953591862682772	3146	8202	1058,3015,55355,5931,8367,54069,201254,64105,51773,8368,55320,8360,79682,8365,401541,121504,8294,3012,8334,23421,8366,8364,3014,55166,8345,79019,8467,8338,57082,8331	CENPA,H2AFZ,HJURP,RBBP7,HIST1H4E,MIS18A,STRA13,CENPK,RSF1,HIST1H4L,MIS18BP1,HIST1H4D,CENPU,HIST1H4H,CENPP,HIST4H4,HIST1H4I,HIST1H2AE,HIST1H2AC,ITGB3BP,HIST1H4B,HIST1H4C,H2AFX,CENPQ,HIST1H2BH,CENPM,SMARCA5,HIST2H2AC,CASC5,HIST1H2AJ
R-HSA-774815	Nucleosome assembly	0.254855886902312	-1.36705704298353	70	30	0.00953591862682772	3146	8202	1058,3015,55355,5931,8367,54069,201254,64105,51773,8368,55320,8360,79682,8365,401541,121504,8294,3012,8334,23421,8366,8364,3014,55166,8345,79019,8467,8338,57082,8331	CENPA,H2AFZ,HJURP,RBBP7,HIST1H4E,MIS18A,STRA13,CENPK,RSF1,HIST1H4L,MIS18BP1,HIST1H4D,CENPU,HIST1H4H,CENPP,HIST4H4,HIST1H4I,HIST1H2AE,HIST1H2AC,ITGB3BP,HIST1H4B,HIST1H4C,H2AFX,CENPQ,HIST1H2BH,CENPM,SMARCA5,HIST2H2AC,CASC5,HIST1H2AJ
R-HSA-5674135	MAP2K and MAPK activation	0.257728296556712	-1.3558493630961	38	17	0.00540368722186904	3146	8202	673,8826,5894,5037,5604,5908,8649,283455,10256,5605,5595,5906,84292,5594,7414,409,3265	BRAF,IQGAP1,RAF1,PEBP1,MAP2K1,RAP1B,LAMTOR3,KSR2,CNKSR1,MAP2K2,MAPK3,RAP1A,WDR83,MAPK1,VCL,ARRB2,HRAS
R-HSA-3323169	Defects in biotin (Btn) metabolism	0.258588015024032	-1.3525191593331	7	4	0.00127145581691036	3146	8202	5096,5091,31,56922	PCCB,PC,ACACA,MCCC1
R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	0.258588015024032	-1.3525191593331	7	4	0.00127145581691036	3146	8202	4088,4087,4089,9372	SMAD3,SMAD2,SMAD4,ZFYVE9
R-HSA-199920	CREB phosphorylation	0.258588015024032	-1.3525191593331	7	4	0.00127145581691036	3146	8202	466,6196,9252,6197	ATF1,RPS6KA2,RPS6KA5,RPS6KA3
R-HSA-447038	NrCAM interactions	0.258588015024032	-1.3525191593331	7	4	0.00127145581691036	3146	8202	1742,1741,8828,1739	DLG4,DLG3,NRP2,DLG1
R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	0.258588015024032	-1.3525191593331	7	4	0.00127145581691036	3146	8202	4088,4087,4089,9372	SMAD3,SMAD2,SMAD4,ZFYVE9
R-HSA-426117	Cation-coupled Chloride cotransporters	0.258588015024032	-1.3525191593331	7	4	0.00127145581691036	3146	8202	10723,9990,6559,6558	SLC12A7,SLC12A6,SLC12A3,SLC12A2
R-HSA-2660826	Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	0.258588015024032	-1.3525191593331	7	4	0.00127145581691036	3146	8202	6868,54567,182,102	ADAM17,DLL4,JAG1,ADAM10
R-HSA-3371599	Defective HLCS causes multiple carboxylase deficiency	0.258588015024032	-1.3525191593331	7	4	0.00127145581691036	3146	8202	5096,5091,31,56922	PCCB,PC,ACACA,MCCC1
R-HSA-5603029	IkBA variant leads to EDA-ID	0.258588015024032	-1.3525191593331	7	4	0.00127145581691036	3146	8202	1147,4791,5970,3551	CHUK,NFKB2,RELA,IKBKB
R-HSA-5649702	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	0.258588015024032	-1.3525191593331	7	4	0.00127145581691036	3146	8202	11284,79661,3980,252969	PNKP,NEIL1,LIG3,NEIL2
R-HSA-2660825	Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	0.258588015024032	-1.3525191593331	7	4	0.00127145581691036	3146	8202	6868,54567,182,102	ADAM17,DLL4,JAG1,ADAM10
R-HSA-164843	2-LTR circle formation	0.258588015024032	-1.3525191593331	7	4	0.00127145581691036	3146	8202	3981,3159,11168,7520	LIG4,HMGA1,PSIP1,XRCC5
R-HSA-917937	Iron uptake and transport	0.261858189876222	-1.33995218176954	43	19	0.00603941513032422	3146	8202	2512,523,9429,537,535,4891,2495,7037,51382,10312,23545,527,51606,528,529,8992,9114,79901,9550	FTL,ATP6V1A,ABCG2,ATP6AP1,ATP6V0A1,SLC11A2,FTH1,TFRC,ATP6V1D,TCIRG1,ATP6V0A2,ATP6V0C,ATP6V1H,ATP6V1C1,ATP6V1E1,ATP6V0E1,ATP6V0D1,CYBRD1,ATP6V1G1
R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	0.263445164383605	-1.33391003746358	14	7	0.00222504767959313	3146	8202	3978,9156,5111,10714,5424,2956,5425	LIG1,EXO1,PCNA,POLD3,POLD1,MSH6,POLD2
R-HSA-162594	Early Phase of HIV Life Cycle	0.263445164383605	-1.33391003746358	14	7	0.00222504767959313	3146	8202	3981,3978,7852,3159,11168,5478,7520	LIG4,LIG1,CXCR4,HMGA1,PSIP1,PPIA,XRCC5
R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	0.263445164383605	-1.33391003746358	14	7	0.00222504767959313	3146	8202	3978,9156,5111,10714,5424,5425,4437	LIG1,EXO1,PCNA,POLD3,POLD1,POLD2,MSH3
R-HSA-877312	Regulation of IFNG signaling	0.263445164383605	-1.33391003746358	14	7	0.00222504767959313	3146	8202	3717,3459,8651,5777,7341,9021,5781	JAK2,IFNGR1,SOCS1,PTPN6,SUMO1,SOCS3,PTPN11
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	0.264902913161115	-1.32839188555388	48	21	0.0066751430387794	3146	8202	1173,8218,102,51107,7410,5879,7525,83464,4067,1947,2534,1969,1945,160,1213,5664,163,2050,1175,23385,2049	AP2M1,CLTCL1,ADAM10,APH1A,VAV2,RAC1,YES1,APH1B,LYN,EFNB1,FYN,EPHA2,EFNA4,AP2A1,CLTC,PSEN2,AP2B1,EPHB4,AP2S1,NCSTN,EPHB3
R-HSA-913531	Interferon Signaling	0.269528572185011	-1.31108087501335	194	79	0.0251112523839797	3146	8202	23321,23511,85363,3661,348995,5495,5696,5610,6672,8651,9775,7706,57122,3660,103,9972,4940,3459,1977,81929,25820,4599,7311,3841,5777,11274,9631,8021,7297,6773,9021,5903,1981,5335,817,3839,53840,6233,80263,684,3838,7334,80128,1958,8480,51191,3430,8672,567,8519,129401,3105,23165,9883,7341,9246,25939,5781,10612,6737,3717,7314,79902,3837,1974,23087,3454,1982,9636,3663,7316,7324,5595,7175,7726,3840,23636,2537,3659	TRIM2,NUP188,TRIM5,IRF3,NUP43,PPM1B,PSMB8,EIF2AK2,SP100,SOCS1,EIF4A3,TRIM25,NUP107,IRF2,ADAR,NUP153,OAS3,IFNGR1,EIF4E,SEH1L,ARIH1,MX1,UBA52,KPNA5,PTPN6,USP18,NUP155,NUP214,TYK2,STAT2,SOCS3,RANBP2,EIF4G1,PLCG1,CAMK2D,KPNA3,TRIM34,RPS27A,TRIM45,BST2,KPNA2,UBE2N,TRIM46,EGR1,RAE1,HERC5,IFI35,EIF4G3,B2M,IFITM1,NUP35,HLA-A,NUP205,POM121,SUMO1,UBE2L6,SAMHD1,PTPN11,TRIM3,TRIM21,JAK2,UBB,NUP85,KPNB1,EIF4A2,TRIM35,IFNAR1,EIF4G2,ISG15,IRF5,UBC,UBE2E1,MAPK3,TPR,TRIM26,KPNA4,NUP62,IFI6,IRF1
R-HSA-75105	Fatty Acyl-CoA Biosynthesis	0.283761998163406	-1.25961942680416	46	20	0.00635727908455181	3146	8202	60481,9374,2180,79071,2181,83401,9200,2194,6319,64834,641371,201562,117145,2182,9524,31,11332,6576,10005,55856	ELOVL5,PPT2,ACSL1,ELOVL6,ACSL3,ELOVL3,HACD1,FASN,SCD,ELOVL1,ACOT1,HACD2,THEM4,ACSL4,TECR,ACACA,ACOT7,SLC25A1,ACOT8,ACOT13
R-HSA-73943	Reversal of alkylation damage by DNA dioxygenases	0.289400918322811	-1.23994229159417	5	3	0.000953591862682772	3146	8202	10973,51008,84164	ASCC3,ASCC1,ASCC2
R-HSA-163358	PKA-mediated phosphorylation of key metabolic factors	0.289400918322811	-1.23994229159417	5	3	0.000953591862682772	3146	8202	51085,5566,5567	MLXIPL,PRKACA,PRKACB
R-HSA-70370	Galactose catabolism	0.289400918322811	-1.23994229159417	5	3	0.000953591862682772	3146	8202	5236,55276,2582	PGM1,PGM2,GALE
R-HSA-1306955	GRB7 events in ERBB2 signaling	0.289400918322811	-1.23994229159417	5	3	0.000953591862682772	3146	8202	2064,2065,2886	ERBB2,ERBB3,GRB7
R-HSA-71032	Propionyl-CoA catabolism	0.289400918322811	-1.23994229159417	5	3	0.000953591862682772	3146	8202	84693,5096,166785	MCEE,PCCB,MMAA
R-HSA-180689	APOBEC3G mediated resistance to HIV-1 infection	0.289400918322811	-1.23994229159417	5	3	0.000953591862682772	3146	8202	3159,11168,5478	HMGA1,PSIP1,PPIA
R-HSA-163680	AMPK inhibits chREBP transcriptional activation activity	0.289400918322811	-1.23994229159417	5	3	0.000953591862682772	3146	8202	51085,51422,5565	MLXIPL,PRKAG2,PRKAB2
R-HSA-203641	NOSTRIN mediated eNOS trafficking	0.289400918322811	-1.23994229159417	5	3	0.000953591862682772	3146	8202	857,8976,1785	CAV1,WASL,DNM2
R-HSA-5368598	Negative regulation of TCF-dependent signaling by DVL-interacting proteins	0.289400918322811	-1.23994229159417	5	3	0.000953591862682772	3146	8202	80319,1857,1856	CXXC4,DVL3,DVL2
R-HSA-426048	Arachidonate production from DAG	0.289400918322811	-1.23994229159417	5	3	0.000953591862682772	3146	8202	221955,26090,57406	DAGLB,ABHD12,ABHD6
R-HSA-5661270	Catabolism of glucuronate to xylulose-5-phosphate	0.289400918322811	-1.23994229159417	5	3	0.000953591862682772	3146	8202	9942,51181,10327	XYLB,DCXR,AKR1A1
R-HSA-3065676	SUMO is conjugated to E1 (UBA2:SAE1)	0.289400918322811	-1.23994229159417	5	3	0.000953591862682772	3146	8202	10055,10054,7341	SAE1,UBA2,SUMO1
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	0.292113762377124	-1.2306119554052	12	6	0.00190718372536554	3146	8202	1147,84282,841,64135,7706,3551	CHUK,RNF135,CASP8,IFIH1,TRIM25,IKBKB
R-HSA-2197563	NOTCH2 intracellular domain regulates transcription	0.292113762377124	-1.2306119554052	12	6	0.00190718372536554	3146	8202	2033,3280,3516,9794,10046,55534	EP300,HES1,RBPJ,MAML1,MAMLD1,MAML3
R-HSA-73621	Pyrimidine catabolism	0.292113762377124	-1.2306119554052	12	6	0.00190718372536554	3146	8202	30833,1890,1806,51251,56953,7378	NT5C,TYMP,DPYD,NT5C3A,NT5M,UPP1
R-HSA-176974	Unwinding of DNA	0.292113762377124	-1.2306119554052	12	6	0.00190718372536554	3146	8202	9837,8318,4175,84296,4172,84515	GINS1,CDC45,MCM6,GINS4,MCM3,MCM8
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	0.295859372928051	-1.21787102900907	29	13	0.00413223140495868	3146	8202	22948,6499,26234,10576,6950,26272,8877,7203,22803,3801,83752,10564,84261	CCT5,SKIV2L,FBXL5,CCT2,TCP1,FBXO4,SPHK1,CCT3,XRN2,KIFC3,LONP2,ARFGEF2,FBXW9
R-HSA-445355	Smooth Muscle Contraction	0.295859372928051	-1.21787102900907	29	13	0.00413223140495868	3146	8202	10398,10580,7170,7169,7171,59,808,4637,7168,7414,3693,4636,140465	MYL9,SORBS1,TPM3,TPM2,TPM4,ACTA2,CALM3,MYL6,TPM1,VCL,ITGB5,MYL5,MYL6B
R-HSA-5601884	PIWI-interacting RNA (piRNA) biogenesis	0.295859372928051	-1.21787102900907	29	13	0.00413223140495868	3146	8202	5432,5438,5436,5441,5440,113802,122402,5434,5433,11022,3320,4603,5430	POLR2C,POLR2I,POLR2G,POLR2L,POLR2K,HENMT1,TDRD9,POLR2E,POLR2D,TDRKH,HSP90AA1,MYBL1,POLR2A
R-HSA-3299685	Detoxification of Reactive Oxygen Species	0.295859372928051	-1.21787102900907	29	13	0.00413223140495868	3146	8202	7296,847,538,9588,5034,30001,6648,9973,318,25828,2876,10587,493869	TXNRD1,CAT,ATP7A,PRDX6,P4HB,ERO1A,SOD2,CCS,NUDT2,TXN2,GPX1,TXNRD2,GPX8
R-HSA-70221	Glycogen breakdown (glycogenolysis)	0.307785505133036	-1.1783521505217	17	8	0.00254291163382072	3146	8202	5236,55276,5837,5255,808,5256,178,5261	PGM1,PGM2,PYGM,PHKA1,CALM3,PHKA2,AGL,PHKG2
R-HSA-373755	Semaphorin interactions	0.322173423080828	-1.13266529742406	67	28	0.00890019071837254	3146	8202	10398,391,387,6237,389,3326,5879,8482,2064,23365,4628,388,5364,27289,2534,1808,3984,5062,3688,2932,4637,23129,3320,6093,8829,9475,2242,3985	MYL9,RHOG,RHOA,RRAS,RHOC,HSP90AB1,RAC1,SEMA7A,ERBB2,ARHGEF12,MYH10,RHOB,PLXNB1,RND1,FYN,DPYSL2,LIMK1,PAK2,ITGB1,GSK3B,MYL6,PLXND1,HSP90AA1,ROCK1,NRP1,ROCK2,FES,LIMK2
R-HSA-438064	Post NMDA receptor activation events	0.32526418200798	-1.12311755913358	37	16	0.00508582326764145	3146	8202	5170,817,10142,673,6196,6237,84254,5894,808,814,1742,5594,5566,3265,5567,6197	PDPK1,CAMK2D,AKAP9,BRAF,RPS6KA2,RRAS,CAMKK1,RAF1,CALM3,CAMK4,DLG4,MAPK1,PRKACA,HRAS,PRKACB,RPS6KA3
R-HSA-189200	Hexose transport	0.325746584704892	-1.12163554743769	47	20	0.00635727908455181	3146	8202	6526,6517,23511,8480,9631,348995,92579,8021,9883,23165,129401,7175,5903,57122,23636,9972,3098,3101,79902,81929	SLC5A3,SLC2A4,NUP188,RAE1,NUP155,NUP43,G6PC3,NUP214,POM121,NUP205,NUP35,TPR,RANBP2,NUP107,NUP62,NUP153,HK1,HK3,NUP85,SEH1L
R-HSA-373752	Netrin-1 signaling	0.325808184217875	-1.12144646275562	42	18	0.00572155117609663	3146	8202	4690,4651,5879,7204,6091,7430,5747,84448,4756,3983,5335,2534,6477,8976,5781,6478,7220,9353	NCK1,MYO10,RAC1,TRIO,ROBO1,EZR,PTK2,ABLIM2,NEO1,ABLIM1,PLCG1,FYN,SIAH1,WASL,PTPN11,SIAH2,TRPC1,SLIT2
R-HSA-5663084	Diseases of carbohydrate metabolism	0.326223507310816	-1.12017252728744	10	5	0.00158931977113795	3146	8202	5507,7311,7314,6233,7316	PPP1R3C,UBA52,UBB,RPS27A,UBC
R-HSA-3229121	Glycogen storage diseases	0.326223507310816	-1.12017252728744	10	5	0.00158931977113795	3146	8202	5507,7311,7314,6233,7316	PPP1R3C,UBA52,UBB,RPS27A,UBC
R-HSA-549127	Organic cation transport	0.326223507310816	-1.12017252728744	10	5	0.00158931977113795	3146	8202	55356,861,6583,5002,6584	SLC22A15,RUNX1,SLC22A4,SLC22A18,SLC22A5
R-HSA-3785653	Myoclonic epilepsy of Lafora	0.326223507310816	-1.12017252728744	10	5	0.00158931977113795	3146	8202	5507,7311,7314,6233,7316	PPP1R3C,UBA52,UBB,RPS27A,UBC
R-HSA-450341	Activation of the AP-1 family of transcription factors	0.326223507310816	-1.12017252728744	10	5	0.00158931977113795	3146	8202	5599,1386,5594,5601,5595	MAPK8,ATF2,MAPK1,MAPK9,MAPK3
R-HSA-174437	Removal of the Flap Intermediate from the C-strand	0.326223507310816	-1.12017252728744	10	5	0.00158931977113795	3146	8202	5111,10714,5424,5425,1763	PCNA,POLD3,POLD1,POLD2,DNA2
R-HSA-2465910	MASTL Facilitates Mitotic Progression	0.326223507310816	-1.12017252728744	10	5	0.00158931977113795	3146	8202	891,983,5519,84930,2029	CCNB1,CDK1,PPP2R1B,MASTL,ENSA
R-HSA-190873	Gap junction degradation	0.326223507310816	-1.12017252728744	10	5	0.00158931977113795	3146	8202	1173,4646,8218,1213,1785	AP2M1,MYO6,CLTCL1,CLTC,DNM2
R-HSA-5627083	RHO GTPases regulate CFTR trafficking	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	23433,57120	RHOQ,GOPC
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected purine	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	4350,4595	MPG,MUTYH
R-HSA-1368071	NR1D1 (REV-ERBA) represses gene expression	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	9611,8841	NCOR1,HDAC3
R-HSA-111458	Formation of apoptosome	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	317,842	APAF1,CASP9
R-HSA-1299308	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	3775,9424	KCNK1,KCNK6
R-HSA-977347	Serine biosynthesis	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	29968,5723	PSAT1,PSPH
R-HSA-428359	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	10644,10643	IGF2BP2,IGF2BP3
R-HSA-177539	Autointegration results in viral DNA circles	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	3159,11168	HMGA1,PSIP1
R-HSA-110331	Cleavage of the damaged purine	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	4350,4595	MPG,MUTYH
R-HSA-3249367	STAT6-mediated induction of chemokines	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	29110,6778	TBK1,STAT6
R-HSA-352238	Breakdown of the nuclear lamina	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	839,4000	CASP6,LMNA
R-HSA-173599	Formation of the active cofactor, UDP-glucuronate	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	7360,7358	UGP2,UGDH
R-HSA-175567	Integration of viral DNA into host genomic DNA	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	3159,11168	HMGA1,PSIP1
R-HSA-964975	Vitamins B6 activation to pyridoxal phosphate	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	55163,8566	PNPO,PDXK
R-HSA-1483248	Synthesis of PIPs at the ER membrane	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	22908,5297	SACM1L,PI4KA
R-HSA-73927	Depurination	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	4350,4595	MPG,MUTYH
R-HSA-170145	Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	890,983	CCNA2,CDK1
R-HSA-1234162	Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	2034,3091	EPAS1,HIF1A
R-HSA-165181	Inhibition of TSC complex formation by PKB	0.328484376643872	-1.11326600187227	3	2	0.000635727908455181	3146	8202	7249,208	TSC2,AKT2
R-HSA-1266738	Developmental Biology	0.337419365222048	-1.08642871507557	710	278	0.0883661792752702	3146	8202	8218,71,102,4917,8482,55740,1050,5720,4628,5519,1387,6721,5688,1785,163,10097,10818,7311,208,100271849,5432,5335,4087,5719,1969,6233,3984,3688,4296,4254,5527,2932,9282,8829,409,5689,5440,389,7410,7204,6091,5715,83464,3983,10092,783,57522,9968,9475,2049,4651,57167,5702,8437,5908,6604,5605,5685,5691,388,5921,8202,160,51586,9440,9611,10109,6197,2033,391,161742,200734,685,6517,26052,9462,5894,8826,5037,10096,5879,6464,23054,6477,10213,4637,2050,1741,5970,5441,3326,5433,8452,1742,10025,4209,214,2260,8660,5529,817,2534,23097,784,5536,5711,9412,1844,673,1173,6929,9252,2309,10298,9491,1947,27289,4756,25,5708,81857,896,5781,2065,84891,7314,5469,6837,2242,5694,6709,6654,8913,80728,5045,7525,5747,5710,84448,7316,5430,3685,84292,10398,2034,4763,5786,6256,785,5906,6196,5696,1499,1808,5701,1739,5664,7220,55588,9353,10498,6453,80205,51107,9978,5468,4690,287,283455,7430,7422,9969,100133941,1213,5690,60,6093,10891,5705,5700,5528,8650,5693,1495,5245,5713,8649,51003,808,4205,10256,5217,1847,59283,7408,84246,112950,6925,1291,5062,9443,1052,3985,5686,5438,6237,3915,8841,10552,10048,5704,9043,2069,6478,5434,6907,10142,5683,5604,2064,5087,4067,29079,5364,5687,10487,9441,6711,23198,92,8986,7414,6655,207,5436,5695,1846,4088,5706,1945,5709,8976,80824,9314,3673,23129,53616,23122,9861,5594,23385,4089,1175,5716,10093,8828,6324,3717,5717,3320,6774,1843,3280,387,1024,7480,5692,5465,3678,23365,5595,2885,5608,84078,152559,3516,7026,3265	CLTCL1,ACTG1,ADAM10,NTN3,SEMA7A,ENAH,CEBPA,PSME1,MYH10,PPP2R1B,CREBBP,SREBF2,PSMA7,DNM2,AP2B1,ACTR2,FRS2,UBA52,AKT2,MEF2B,POLR2C,PLCG1,SMAD2,PSMD13,EPHA2,RPS27A,LIMK1,ITGB1,MAP3K11,KITLG,PPP2R5C,GSK3B,MED14,NRP1,ARRB2,PSMB1,POLR2K,RHOC,VAV2,TRIO,ROBO1,PSMD9,APH1B,ABLIM1,ARPC5,CACNB2,SRGAP1,MED12,ROCK2,EPHB3,MYO10,SALL4,PSMC3,RASAL1,RAP1B,SMARCD3,MAP2K2,PSMA4,PSMB3,RHOB,RASA1,NCOA3,AP2A1,MED15,MED17,NCOR1,ARPC2,RPS6KA3,EP300,RHOG,SPRED1,SPRED2,BTC,SLC2A4,DNM3,RASAL2,RAF1,IQGAP1,PEBP1,ACTR3,RAC1,SHC1,NCOA6,SIAH1,PSMD14,MYL6,EPHB4,DLG3,RELA,POLR2L,HSP90AB1,POLR2D,CUL3,DLG4,MED16,MEF2D,ALCAM,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,CDK19,CACNB3,PPP5C,PSMD5,MED21,DUSP2,BRAF,AP2M1,TCF3,RPS6KA5,FOXO3,PAK4,PSMF1,EFNB1,RND1,NEO1,ABL1,PSMD2,MED25,CCND3,PTPN11,ERBB3,ZSCAN10,UBB,MED1,MED22,FES,PSMB6,SPTAN1,SOS1,CACNA1G,ARHGAP39,FURIN,YES1,PTK2,PSMD4,ABLIM2,UBC,POLR2A,ITGAV,WDR83,MYL9,EPAS1,NF1,PTPRA,RXRA,CACNB4,RAP1A,RPS6KA2,PSMB8,CTNNB1,DPYSL2,PSMC2,DLG1,PSEN2,TRPC1,MED29,SLIT2,CARM1,ITSN1,CHD9,APH1A,RBX1,PPARG,NCK1,ANK2,KSR2,EZR,VEGFA,MED13,CD24,CLTC,PSMB2,ACTB,ROCK1,PPARGC1A,PSMC5,PSMC1,PPP2R5D,NUMB,PSMB5,CTNNA1,PHB,PSMD7,LAMTOR3,MED31,CALM3,MEF2A,CNKSR1,PFN2,DUSP5,CACNG8,VASP,MED10,MED8,TCF4,COL6A1,PAK2,MED7,CEBPD,LIMK2,PSMA5,POLR2I,RRAS,LAMC1,HDAC3,ARPC1A,RANBP9,PSMC4,SPAG9,EREG,SIAH2,POLR2E,TBL1X,AKAP9,PSMA2,MAP2K1,ERBB2,PBX1,LYN,MED4,PLXNB1,PSMA6,CAP1,MED26,SPTBN1,PSME4,ACVR2A,RPS6KA4,VCL,SOS2,AKT1,POLR2G,PSMB7,DUSP4,SMAD3,PSMC6,EFNA4,PSMD3,WASL,DUSP16,KLF4,ITGA2,PLXND1,ADAM22,CLASP2,PSMD6,MAPK1,NCSTN,SMAD4,AP2S1,PSMD10,ARPC4,NRP2,SCN1B,JAK2,PSMD11,HSP90AA1,STAT3,DUSP1,HES1,RHOA,CDK8,WNT10B,PSMB4,PPARA,ITGA5,ARHGEF12,MAPK3,GRB2,MAP2K6,KBTBD7,PAQR3,RBPJ,NR2F2,HRAS
R-HSA-193648	NRAGE signals death through JNK	0.348037451586174	-1.05544518549773	45	19	0.00603941513032422	3146	8202	5599,6655,50650,6654,10276,7410,5879,7204,84033,23365,11214,57449,9181,10018,9828,23229,64857,6453,2245	MAPK8,SOS2,ARHGEF3,SOS1,NET1,VAV2,RAC1,TRIO,OBSCN,ARHGEF12,AKAP13,PLEKHG5,ARHGEF2,BCL2L11,ARHGEF17,ARHGEF9,PLEKHG2,ITSN1,FGD1
R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	0.349017364261004	-1.05263360368789	25	11	0.0034965034965035	3146	8202	60481,9374,2180,201562,79071,2181,83401,9200,2182,9524,64834	ELOVL5,PPT2,ACSL1,HACD2,ELOVL6,ACSL3,ELOVL3,HACD1,ACSL4,TECR,ELOVL1
R-HSA-1251985	Nuclear signaling by ERBB4	0.349218640906918	-1.05205707469197	40	17	0.00540368722186904	3146	8202	685,6868,9978,51107,10413,8454,6777,83464,23118,25970,2069,5781,5664,6776,3717,9611,23385	BTC,ADAM17,RBX1,APH1A,YAP1,CUL1,STAT5B,APH1B,TAB2,SH2B1,EREG,PTPN11,PSEN2,STAT5A,JAK2,NCOR1,NCSTN
R-HSA-2871809	FCERI mediated Ca+2 mobilization	0.350023039650325	-1.04975629909286	30	13	0.00413223140495868	3146	8202	2885,5335,6464,6654,3708,7410,5534,808,5532,3709,10768,3710,4067	GRB2,PLCG1,SHC1,SOS1,ITPR1,VAV2,PPP3R1,CALM3,PPP3CB,ITPR2,AHCYL1,ITPR3,LYN
R-HSA-5340588	RNF mutants show enhanced WNT signaling and proliferation	0.368011872187489	-0.999640079954546	8	4	0.00127145581691036	3146	8202	4040,7855,8322,8325	LRP6,FZD5,FZD4,FZD8
R-HSA-199418	Negative regulation of the PI3K/AKT network	0.368011872187489	-0.999640079954546	8	4	0.00127145581691036	3146	8202	57761,207,208,117145	TRIB3,AKT1,AKT2,THEM4
R-HSA-5358493	Synthesis of diphthamide-EEF2	0.368011872187489	-0.999640079954546	8	4	0.00127145581691036	3146	8202	120526,1938,1801,1802	DNAJC24,EEF2,DPH1,DPH2
R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	0.368011872187489	-0.999640079954546	8	4	0.00127145581691036	3146	8202	4088,4087,4089,9372	SMAD3,SMAD2,SMAD4,ZFYVE9
R-HSA-72731	Recycling of eIF2:GDP	0.368011872187489	-0.999640079954546	8	4	0.00127145581691036	3146	8202	8892,1965,1968,1967	EIF2B2,EIF2S1,EIF2S3,EIF2B1
R-HSA-446388	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	0.368011872187489	-0.999640079954546	8	4	0.00127145581691036	3146	8202	29780,87,3987,6251	PARVB,ACTN1,LIMS1,RSU1
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	0.369474526121109	-0.995673482455952	104	42	0.0133502860775588	3146	8202	23112,685,7249,2475,79109,2064,1147,1026,4067,2309,4193,6464,5296,117145,5781,1027,8503,253260,2065,10818,64223,6199,5170,207,2931,4303,6654,3164,208,842,5295,2260,2885,8660,57761,2534,2069,4254,2932,4343,2549,192669	TNRC6B,BTC,TSC2,MTOR,MAPKAP1,ERBB2,CHUK,CDKN1A,LYN,FOXO3,MDM2,SHC1,PIK3R2,THEM4,PTPN11,CDKN1B,PIK3R3,RICTOR,ERBB3,FRS2,MLST8,RPS6KB2,PDPK1,AKT1,GSK3A,FOXO4,SOS1,NR4A1,AKT2,CASP9,PIK3R1,FGFR1,GRB2,IRS2,TRIB3,FYN,EREG,KITLG,GSK3B,MOV10,GAB1,AGO3
R-HSA-5357786	TNFR1-induced proapoptotic signaling	0.377468115747547	-0.974269175456041	13	6	0.00190718372536554	3146	8202	7375,7128,841,56957,7186,27005	USP4,TNFAIP3,CASP8,OTUD7B,TRAF2,USP21
R-HSA-1483213	Synthesis of PE	0.377468115747547	-0.974269175456041	13	6	0.00190718372536554	3146	8202	162466,85465,5833,64900,1119,55500	PHOSPHO1,EPT1,PCYT2,LPIN3,CHKA,ETNK1
R-HSA-210993	Tie2 Signaling	0.380034283254744	-0.967493811239771	18	8	0.00254291163382072	3146	8202	2885,6464,6654,3265,5296,2886,5295,5781	GRB2,SHC1,SOS1,HRAS,PIK3R2,GRB7,PIK3R1,PTPN11
R-HSA-5340573	WNT ligand secretion is abrogated by the PORCN inhibitor LGK974	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	64840	PORCN
R-HSA-389542	NADPH regeneration	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	3417	IDH1
R-HSA-163316	Mitochondrial transcription termination	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	7978	MTERF1
R-HSA-169131	Inhibition of PKR	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	5610	EIF2AK2
R-HSA-5657655	MGMT-mediated DNA damage reversal	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	4255	MGMT
R-HSA-162589	Reverse Transcription of HIV RNA	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	5478	PPIA
R-HSA-171286	Synthesis and processing of ENV and VPU	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	5045	FURIN
R-HSA-3359474	Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	25974	MMACHC
R-HSA-162585	Uncoating of the HIV Virion	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	5478	PPIA
R-HSA-164525	Plus-strand DNA synthesis	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	5478	PPIA
R-HSA-1839120	Signaling by FGFR1 amplification mutants	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	2260	FGFR1
R-HSA-164516	Minus-strand DNA synthesis	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	5478	PPIA
R-HSA-2466712	Biosynthesis of A2E, implicated in retinal degradation	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	222236	NAPEPLD
R-HSA-5467333	APC truncation mutants are not K63 polyubiquitinated	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	324	APC
R-HSA-2978092	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	0.383564984147563	-0.958246222340676	1	1	0.000317863954227591	3146	8202	3417	IDH1
R-HSA-1660661	Sphingolipid de novo biosynthesis	0.401424014154333	-0.912737018414552	36	15	0.00476795931341386	3146	8202	2531,221,8611,253782,8560,91012,8612,10087,55331,8877,9217,5007,9517,56848,224	KDSR,ALDH3B1,PLPP1,CERS6,DEGS1,CERS5,PLPP2,COL4A3BP,ACER3,SPHK1,VAPB,OSBP,SPTLC2,SPHK2,ALDH3A2
R-HSA-422475	Axon guidance	0.403502563573193	-0.90757243795107	516	201	0.0638906547997457	3146	8202	10398,8218,71,102,4763,5786,8482,55740,5720,785,4628,5519,5906,5696,6196,1808,5688,5701,1739,5664,1785,163,7220,10097,10818,9353,6453,7311,4690,9978,51107,287,7430,283455,7422,5335,100133941,5719,1969,6233,3984,1213,3688,4296,4254,5690,2932,5527,60,6093,8829,5705,409,5700,5528,8650,5689,5693,389,7410,5245,7204,6091,8649,5713,808,10256,5715,83464,5217,1847,3983,7408,10092,783,5062,1291,57522,9475,5686,3985,2049,3915,6237,4651,5702,8437,5908,10552,5605,5685,10048,5691,388,5921,5704,160,6478,2069,10109,6197,391,161742,200734,685,10142,26052,9462,5683,5894,8826,5037,10096,5879,5604,2064,4067,5364,5687,6464,10487,6477,6711,23198,10213,4637,8986,2050,1741,7414,6655,3326,8452,5695,1742,1846,214,2260,8660,5529,817,2534,5706,1945,8976,5709,80824,3673,23129,23122,784,5536,9861,5594,1175,23385,5711,1844,1173,673,5716,10093,9252,10298,1947,9491,8828,27289,4756,25,5708,6324,5781,3717,5717,3320,2065,7314,2242,1843,6709,5694,387,5692,6654,8913,80728,3678,23365,7525,5747,5710,84448,7316,5595,2885,84078,152559,3685,84292,3265	MYL9,CLTCL1,ACTG1,ADAM10,NF1,PTPRA,SEMA7A,ENAH,PSME1,CACNB4,MYH10,PPP2R1B,RAP1A,PSMB8,RPS6KA2,DPYSL2,PSMA7,PSMC2,DLG1,PSEN2,DNM2,AP2B1,TRPC1,ACTR2,FRS2,SLIT2,ITSN1,UBA52,NCK1,RBX1,APH1A,ANK2,EZR,KSR2,VEGFA,PLCG1,CD24,PSMD13,EPHA2,RPS27A,LIMK1,CLTC,ITGB1,MAP3K11,KITLG,PSMB2,GSK3B,PPP2R5C,ACTB,ROCK1,NRP1,PSMC5,ARRB2,PSMC1,PPP2R5D,NUMB,PSMB1,PSMB5,RHOC,VAV2,PHB,TRIO,ROBO1,LAMTOR3,PSMD7,CALM3,CNKSR1,PSMD9,APH1B,PFN2,DUSP5,ABLIM1,VASP,ARPC5,CACNB2,PAK2,COL6A1,SRGAP1,ROCK2,PSMA5,LIMK2,EPHB3,LAMC1,RRAS,MYO10,PSMC3,RASAL1,RAP1B,ARPC1A,MAP2K2,PSMA4,RANBP9,PSMB3,RHOB,RASA1,PSMC4,AP2A1,SIAH2,EREG,ARPC2,RPS6KA3,RHOG,SPRED1,SPRED2,BTC,AKAP9,DNM3,RASAL2,PSMA2,RAF1,IQGAP1,PEBP1,ACTR3,RAC1,MAP2K1,ERBB2,LYN,PLXNB1,PSMA6,SHC1,CAP1,SIAH1,SPTBN1,PSME4,PSMD14,MYL6,RPS6KA4,EPHB4,DLG3,VCL,SOS2,HSP90AB1,CUL3,PSMB7,DLG4,DUSP4,ALCAM,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMC6,EFNA4,WASL,PSMD3,DUSP16,ITGA2,PLXND1,CLASP2,CACNB3,PPP5C,PSMD6,MAPK1,AP2S1,NCSTN,PSMD5,DUSP2,AP2M1,BRAF,PSMD10,ARPC4,RPS6KA5,PAK4,EFNB1,PSMF1,NRP2,RND1,NEO1,ABL1,PSMD2,SCN1B,PTPN11,JAK2,PSMD11,HSP90AA1,ERBB3,UBB,FES,DUSP1,SPTAN1,PSMB6,RHOA,PSMB4,SOS1,CACNA1G,ARHGAP39,ITGA5,ARHGEF12,YES1,PTK2,PSMD4,ABLIM2,UBC,MAPK3,GRB2,KBTBD7,PAQR3,ITGAV,WDR83,HRAS
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	0.41004390547534	-0.891491038491916	26	11	0.0034965034965035	3146	8202	3146,10392,23118,257397,3551,1660,1147,4791,4793,10454,5970	HMGB1,NOD1,TAB2,TAB3,IKBKB,DHX9,CHUK,NFKB2,NFKBIB,TAB1,RELA
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	0.41004390547534	-0.891491038491916	26	11	0.0034965034965035	3146	8202	3146,29110,3551,23220,1660,148022,1147,3661,4791,4793,5970	HMGB1,TBK1,IKBKB,DTX4,DHX9,TICAM1,CHUK,IRF3,NFKB2,NFKBIB,RELA
R-HSA-390466	Chaperonin-mediated protein folding	0.413562636478829	-0.882946297202166	49	20	0.00635727908455181	3146	8202	6499,10576,7280,7411,10383,26272,8877,7203,3801,10471,5201,26234,22948,6950,60,22803,83752,10381,84261,10564	SKIV2L,CCT2,TUBB2A,VBP1,TUBB4B,FBXO4,SPHK1,CCT3,KIFC3,PFDN6,PFDN1,FBXL5,CCT5,TCP1,ACTB,XRN2,LONP2,TUBB3,FBXW9,ARFGEF2
R-HSA-2219528	PI3K/AKT Signaling in Cancer	0.417165377636058	-0.874272546748694	85	34	0.0108073744437381	3146	8202	685,7249,2475,79109,2064,1147,1026,2309,4193,5296,5781,8503,1027,253260,2065,10818,6199,64223,5170,2931,207,4303,3164,208,5295,842,2260,2885,8660,2534,2069,2932,4254,2549	BTC,TSC2,MTOR,MAPKAP1,ERBB2,CHUK,CDKN1A,FOXO3,MDM2,PIK3R2,PTPN11,PIK3R3,CDKN1B,RICTOR,ERBB3,FRS2,RPS6KB2,MLST8,PDPK1,GSK3A,AKT1,FOXO4,NR4A1,AKT2,PIK3R1,CASP9,FGFR1,GRB2,IRS2,FYN,EREG,GSK3B,KITLG,GAB1
R-HSA-1170546	Prolactin receptor signaling	0.418603159483936	-0.870831921258788	16	7	0.00222504767959313	3146	8202	8454,3717,6777,6776,9978,25970,5781	CUL1,JAK2,STAT5B,STAT5A,RBX1,SH2B1,PTPN11
R-HSA-446353	Cell-extracellular matrix interactions	0.418603159483936	-0.870831921258788	16	7	0.00222504767959313	3146	8202	10979,29780,87,7408,3987,6251,3688	FERMT2,PARVB,ACTN1,VASP,LIMS1,RSU1,ITGB1
R-HSA-5362517	Signaling by Retinoic Acid	0.418807575183286	-0.870343712319143	44	18	0.00572155117609663	3146	8202	5915,5160,5914,317749,5163,6256,1375,5165,9249,8050,1592,51109,6257,728635,5164,5467,57665,5916	RARB,PDHA1,RARA,DHRS4L2,PDK1,RXRA,CPT1B,PDK3,DHRS3,PDHX,CYP26A1,RDH11,RXRB,DHRS4L1,PDK2,PPARD,RDH14,RARG
R-HSA-5334118	DNA methylation	0.421532984880362	-0.863857248658145	62	25	0.00794659885568976	3146	8202	8352,8968,3015,8367,8358,8350,8368,8357,8360,8365,121504,8294,3012,8334,8366,8364,8351,3014,653604,8345,3020,8338,29128,8331,8354	HIST1H3C,HIST1H3F,H2AFZ,HIST1H4E,HIST1H3B,HIST1H3A,HIST1H4L,HIST1H3H,HIST1H4D,HIST1H4H,HIST4H4,HIST1H4I,HIST1H2AE,HIST1H2AC,HIST1H4B,HIST1H4C,HIST1H3D,H2AFX,HIST2H3D,HIST1H2BH,H3F3A,HIST2H2AC,UHRF1,HIST1H2AJ,HIST1H3I
R-HSA-1250342	PI3K events in ERBB4 signaling	0.421592819364379	-0.8637153137682	98	39	0.012396694214876	3146	8202	23112,685,7249,2475,79109,2064,1147,1026,2309,4193,5296,117145,5781,8503,1027,253260,2065,10818,64223,6199,5170,207,2931,4303,3164,208,5295,842,2260,2885,8660,57761,2534,2069,4254,2932,4343,2549,192669	TNRC6B,BTC,TSC2,MTOR,MAPKAP1,ERBB2,CHUK,CDKN1A,FOXO3,MDM2,PIK3R2,THEM4,PTPN11,PIK3R3,CDKN1B,RICTOR,ERBB3,FRS2,MLST8,RPS6KB2,PDPK1,AKT1,GSK3A,FOXO4,NR4A1,AKT2,PIK3R1,CASP9,FGFR1,GRB2,IRS2,TRIB3,FYN,EREG,KITLG,GSK3B,MOV10,GAB1,AGO3
R-HSA-5654720	PI-3K cascade:FGFR4	0.421592819364379	-0.8637153137682	98	39	0.012396694214876	3146	8202	23112,685,7249,2475,79109,2064,1147,1026,2309,4193,5296,117145,5781,8503,1027,253260,2065,10818,64223,6199,5170,207,2931,4303,3164,208,5295,842,2260,2885,8660,57761,2534,2069,4254,2932,4343,2549,192669	TNRC6B,BTC,TSC2,MTOR,MAPKAP1,ERBB2,CHUK,CDKN1A,FOXO3,MDM2,PIK3R2,THEM4,PTPN11,PIK3R3,CDKN1B,RICTOR,ERBB3,FRS2,MLST8,RPS6KB2,PDPK1,AKT1,GSK3A,FOXO4,NR4A1,AKT2,PIK3R1,CASP9,FGFR1,GRB2,IRS2,TRIB3,FYN,EREG,KITLG,GSK3B,MOV10,GAB1,AGO3
R-HSA-5654689	PI-3K cascade:FGFR1	0.421592819364379	-0.8637153137682	98	39	0.012396694214876	3146	8202	23112,685,7249,2475,79109,2064,1147,1026,2309,4193,5296,117145,5781,8503,1027,253260,2065,10818,64223,6199,5170,207,2931,4303,3164,208,5295,842,2260,2885,8660,57761,2534,2069,4254,2932,4343,2549,192669	TNRC6B,BTC,TSC2,MTOR,MAPKAP1,ERBB2,CHUK,CDKN1A,FOXO3,MDM2,PIK3R2,THEM4,PTPN11,PIK3R3,CDKN1B,RICTOR,ERBB3,FRS2,MLST8,RPS6KB2,PDPK1,AKT1,GSK3A,FOXO4,NR4A1,AKT2,PIK3R1,CASP9,FGFR1,GRB2,IRS2,TRIB3,FYN,EREG,KITLG,GSK3B,MOV10,GAB1,AGO3
R-HSA-5654695	PI-3K cascade:FGFR2	0.421592819364379	-0.8637153137682	98	39	0.012396694214876	3146	8202	23112,685,7249,2475,79109,2064,1147,1026,2309,4193,5296,117145,5781,8503,1027,253260,2065,10818,64223,6199,5170,207,2931,4303,3164,208,5295,842,2260,2885,8660,57761,2534,2069,4254,2932,4343,2549,192669	TNRC6B,BTC,TSC2,MTOR,MAPKAP1,ERBB2,CHUK,CDKN1A,FOXO3,MDM2,PIK3R2,THEM4,PTPN11,PIK3R3,CDKN1B,RICTOR,ERBB3,FRS2,MLST8,RPS6KB2,PDPK1,AKT1,GSK3A,FOXO4,NR4A1,AKT2,PIK3R1,CASP9,FGFR1,GRB2,IRS2,TRIB3,FYN,EREG,KITLG,GSK3B,MOV10,GAB1,AGO3
R-HSA-5654710	PI-3K cascade:FGFR3	0.421592819364379	-0.8637153137682	98	39	0.012396694214876	3146	8202	23112,685,7249,2475,79109,2064,1147,1026,2309,4193,5296,117145,5781,8503,1027,253260,2065,10818,64223,6199,5170,207,2931,4303,3164,208,5295,842,2260,2885,8660,57761,2534,2069,4254,2932,4343,2549,192669	TNRC6B,BTC,TSC2,MTOR,MAPKAP1,ERBB2,CHUK,CDKN1A,FOXO3,MDM2,PIK3R2,THEM4,PTPN11,PIK3R3,CDKN1B,RICTOR,ERBB3,FRS2,MLST8,RPS6KB2,PDPK1,AKT1,GSK3A,FOXO4,NR4A1,AKT2,PIK3R1,CASP9,FGFR1,GRB2,IRS2,TRIB3,FYN,EREG,KITLG,GSK3B,MOV10,GAB1,AGO3
R-HSA-1257604	PIP3 activates AKT signaling	0.421592819364379	-0.8637153137682	98	39	0.012396694214876	3146	8202	23112,685,7249,2475,79109,2064,1147,1026,2309,4193,5296,117145,5781,1027,8503,253260,2065,10818,6199,64223,5170,207,2931,4303,3164,208,5295,842,2260,2885,8660,57761,2534,2069,4254,2932,4343,2549,192669	TNRC6B,BTC,TSC2,MTOR,MAPKAP1,ERBB2,CHUK,CDKN1A,FOXO3,MDM2,PIK3R2,THEM4,PTPN11,CDKN1B,PIK3R3,RICTOR,ERBB3,FRS2,RPS6KB2,MLST8,PDPK1,AKT1,GSK3A,FOXO4,NR4A1,AKT2,PIK3R1,CASP9,FGFR1,GRB2,IRS2,TRIB3,FYN,EREG,KITLG,GSK3B,MOV10,GAB1,AGO3
R-HSA-1963642	PI3K events in ERBB2 signaling	0.421592819364379	-0.8637153137682	98	39	0.012396694214876	3146	8202	23112,685,7249,2475,79109,2064,1147,1026,2309,4193,5296,117145,5781,8503,1027,253260,2065,10818,64223,6199,5170,207,2931,4303,3164,208,5295,842,2260,2885,8660,57761,2534,2069,4254,2932,4343,2549,192669	TNRC6B,BTC,TSC2,MTOR,MAPKAP1,ERBB2,CHUK,CDKN1A,FOXO3,MDM2,PIK3R2,THEM4,PTPN11,PIK3R3,CDKN1B,RICTOR,ERBB3,FRS2,MLST8,RPS6KB2,PDPK1,AKT1,GSK3A,FOXO4,NR4A1,AKT2,PIK3R1,CASP9,FGFR1,GRB2,IRS2,TRIB3,FYN,EREG,KITLG,GSK3B,MOV10,GAB1,AGO3
R-HSA-193670	p75NTR negatively regulates cell cycle via SC1	0.421622151551365	-0.863645741504876	6	3	0.000953591862682772	3146	8202	3065,3066,8841	HDAC1,HDAC2,HDAC3
R-HSA-5660668	CLEC7A/inflammasome pathway	0.421622151551365	-0.863645741504876	6	3	0.000953591862682772	3146	8202	841,5970,10892	CASP8,RELA,MALT1
R-HSA-171319	Telomere Extension By Telomerase	0.421622151551365	-0.863645741504876	6	3	0.000953591862682772	3146	8202	10856,1736,55135	RUVBL2,DKC1,WRAP53
R-HSA-174362	Transport and synthesis of PAPS	0.421622151551365	-0.863645741504876	6	3	0.000953591862682772	3146	8202	1836,347734,9061	SLC26A2,SLC35B2,PAPSS1
R-HSA-5693548	Sensing of DNA Double Strand Breaks	0.421622151551365	-0.863645741504876	6	3	0.000953591862682772	3146	8202	10524,4361,3838	KAT5,MRE11A,KPNA2
R-HSA-77111	Synthesis of Ketone Bodies	0.421622151551365	-0.863645741504876	6	3	0.000953591862682772	3146	8202	38,3155,65985	ACAT1,HMGCL,AACS
R-HSA-5579029	Metabolic disorders of biological oxidation enzymes	0.421622151551365	-0.863645741504876	6	3	0.000953591862682772	3146	8202	112812,2230,2232	FDX1L,FDX1,FDXR
R-HSA-3065678	SUMO is transferred from E1 to E2 (UBE2I, UBC9)	0.421622151551365	-0.863645741504876	6	3	0.000953591862682772	3146	8202	10055,10054,7341	SAE1,UBA2,SUMO1
R-HSA-1606341	IRF3 mediated activation of type 1 IFN	0.421622151551365	-0.863645741504876	6	3	0.000953591862682772	3146	8202	3661,29110,23220	IRF3,TBK1,DTX4
R-HSA-3065679	SUMO is proteolytically processed	0.421622151551365	-0.863645741504876	6	3	0.000953591862682772	3146	8202	205564,29843,7341	SENP5,SENP1,SUMO1
R-HSA-2142770	Synthesis of 15-eicosatetraenoic acid derivatives	0.421622151551365	-0.863645741504876	6	3	0.000953591862682772	3146	8202	5743,2876,2879	PTGS2,GPX1,GPX4
R-HSA-442717	CREB phosphorylation through the activation of CaMKK	0.421622151551365	-0.863645741504876	6	3	0.000953591862682772	3146	8202	808,814,84254	CALM3,CAMK4,CAMKK1
R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer	0.421622151551365	-0.863645741504876	6	3	0.000953591862682772	3146	8202	4088,4087,9372	SMAD3,SMAD2,ZFYVE9
R-HSA-351906	Apoptotic cleavage of cell adhesion  proteins	0.421938793640808	-0.862895014231122	11	5	0.00158931977113795	3146	8202	836,7082,1499,1832,1829	CASP3,TJP1,CTNNB1,DSP,DSG2
R-HSA-1266695	Interleukin-7 signaling	0.421938793640808	-0.862895014231122	11	5	0.00158931977113795	3146	8202	8503,6777,6776,5296,5295	PIK3R3,STAT5B,STAT5A,PIK3R2,PIK3R1
R-HSA-71240	Tryptophan catabolism	0.421938793640808	-0.862895014231122	11	5	0.00158931977113795	3146	8202	56267,883,51166,125061,8942	CCBL2,CCBL1,AADAT,AFMID,KYNU
R-HSA-2514853	Condensation of Prometaphase Chromosomes	0.421938793640808	-0.862895014231122	11	5	0.00158931977113795	3146	8202	10592,891,9133,983,10051	SMC2,CCNB1,CCNB2,CDK1,SMC4
R-HSA-3928663	EPHA-mediated growth cone collapse	0.430479910007829	-0.842854622851753	34	14	0.00445009535918627	3146	8202	10398,2534,387,1969,1945,4637,3320,7525,5747,6093,7422,4628,4067,9475	MYL9,FYN,RHOA,EPHA2,EFNA4,MYL6,HSP90AA1,YES1,PTK2,ROCK1,VEGFA,MYH10,LYN,ROCK2
R-HSA-198203	PI3K/AKT activation	0.434872833085056	-0.832701628367961	101	40	0.0127145581691036	3146	8202	23112,685,7249,2475,79109,2064,1147,1026,2309,4193,5296,117145,5781,8503,1027,253260,2065,10818,64223,6199,5170,387,207,2931,4303,3164,208,5295,842,2260,2885,8660,57761,2534,2069,4254,2932,4343,2549,192669	TNRC6B,BTC,TSC2,MTOR,MAPKAP1,ERBB2,CHUK,CDKN1A,FOXO3,MDM2,PIK3R2,THEM4,PTPN11,PIK3R3,CDKN1B,RICTOR,ERBB3,FRS2,MLST8,RPS6KB2,PDPK1,RHOA,AKT1,GSK3A,FOXO4,NR4A1,AKT2,PIK3R1,CASP9,FGFR1,GRB2,IRS2,TRIB3,FYN,EREG,KITLG,GSK3B,MOV10,GAB1,AGO3
R-HSA-375170	CDO in myogenesis	0.437110058360972	-0.827570265799108	29	12	0.00381436745073109	3146	8202	25,9043,1499,6925,1495,5608,6929,4917,100271849,4205,4209,4756	ABL1,SPAG9,CTNNB1,TCF4,CTNNA1,MAP2K6,TCF3,NTN3,MEF2B,MEF2A,MEF2D,NEO1
R-HSA-525793	Myogenesis	0.437110058360972	-0.827570265799108	29	12	0.00381436745073109	3146	8202	25,9043,1499,6925,1495,5608,6929,4917,100271849,4205,4209,4756	ABL1,SPAG9,CTNNB1,TCF4,CTNNA1,MAP2K6,TCF3,NTN3,MEF2B,MEF2A,MEF2D,NEO1
R-HSA-442742	CREB phosphorylation through the activation of Ras	0.437110058360972	-0.827570265799108	29	12	0.00381436745073109	3146	8202	5170,817,10142,673,6196,6237,5894,808,1742,5594,3265,6197	PDPK1,CAMK2D,AKAP9,BRAF,RPS6KA2,RRAS,RAF1,CALM3,DLG4,MAPK1,HRAS,RPS6KA3
R-HSA-1839124	FGFR1 mutant receptor activation	0.437110058360972	-0.827570265799108	29	12	0.00381436745073109	3146	8202	2885,11116,8805,5295,399687,1523,6777,6776,6774,11052,26127,2260	GRB2,FGFR1OP,TRIM24,PIK3R1,MYO18A,CUX1,STAT5B,STAT5A,STAT3,CPSF6,FGFR1OP2,FGFR1
R-HSA-391251	Protein folding	0.451126610596268	-0.796007245848183	55	22	0.00699300699300699	3146	8202	6499,10576,7280,7411,10383,26272,8877,7203,3801,1155,10471,5201,22948,26234,6950,6904,60,22803,83752,10381,84261,10564	SKIV2L,CCT2,TUBB2A,VBP1,TUBB4B,FBXO4,SPHK1,CCT3,KIFC3,TBCB,PFDN6,PFDN1,CCT5,FBXL5,TCP1,TBCD,ACTB,XRN2,LONP2,TUBB3,FBXW9,ARFGEF2
R-HSA-156590	Glutathione conjugation	0.453351172447537	-0.791088238707164	37	15	0.00476795931341386	3146	8202	373156,26873,2954,79017,119391,2729,4259,2948,2952,4258,55748,2098,4257,2937,10327	GSTK1,OPLAH,GSTZ1,GGCT,GSTO2,GCLC,MGST3,GSTM4,GSTT1,MGST2,CNDP2,ESD,MGST1,GSS,AKR1A1
R-HSA-388841	Costimulation by the CD28 family	0.45463497371869	-0.788260437573717	68	27	0.00858232676414495	3146	8202	5170,207,2475,208,5777,5879,5295,79109,29126,7525,4067,5519,2885,5529,57761,2534,5062,5296,117145,5781,5527,8503,253260,9020,23308,5528,64223	PDPK1,AKT1,MTOR,AKT2,PTPN6,RAC1,PIK3R1,MAPKAP1,CD274,YES1,LYN,PPP2R1B,GRB2,PPP2R5E,TRIB3,FYN,PAK2,PIK3R2,THEM4,PTPN11,PPP2R5C,PIK3R3,RICTOR,MAP3K14,ICOSLG,PPP2R5D,MLST8
R-HSA-2162123	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	0.462985329260212	-0.770059911660964	14	6	0.00190718372536554	3146	8202	127281,5743,22949,10728,9536,6916	FAM213B,PTGS2,PTGR1,PTGES3,PTGES,TBXAS1
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	0.462985329260212	-0.770059911660964	14	6	0.00190718372536554	3146	8202	2534,8829,6237,5879,2242,27289	FYN,NRP1,RRAS,RAC1,FES,RND1
R-HSA-1500620	Meiosis	0.467107224497319	-0.761196444889939	115	45	0.0143038779402416	3146	8202	3015,8367,8358,8350,641,8360,4000,8365,121504,54386,9126,65057,8366,8364,26277,4361,653604,8345,4438,8331,8968,8352,25777,10274,23224,256126,29893,10735,11144,672,11083,8368,8357,8294,5889,3012,8334,5888,8351,8243,3014,8338,3020,7013,8354	H2AFZ,HIST1H4E,HIST1H3B,HIST1H3A,BLM,HIST1H4D,LMNA,HIST1H4H,HIST4H4,TERF2IP,SMC3,ACD,HIST1H4B,HIST1H4C,TINF2,MRE11A,HIST2H3D,HIST1H2BH,MSH4,HIST1H2AJ,HIST1H3F,HIST1H3C,SUN2,STAG1,SYNE2,SYCE2,PSMC3IP,STAG2,DMC1,BRCA1,DIDO1,HIST1H4L,HIST1H3H,HIST1H4I,RAD51C,HIST1H2AE,HIST1H2AC,RAD51,HIST1H3D,SMC1A,H2AFX,HIST2H2AC,H3F3A,TERF1,HIST1H3I
R-HSA-389957	Prefoldin mediated transfer of substrate  to CCT/TriC	0.471187073362648	-0.752500080461964	27	11	0.0034965034965035	3146	8202	22948,10576,7280,6950,7411,10383,7203,60,10471,5201,10381	CCT5,CCT2,TUBB2A,TCP1,VBP1,TUBB4B,CCT3,ACTB,PFDN6,PFDN1,TUBB3
R-HSA-180024	DARPP-32 events	0.471187073362648	-0.752500080461964	27	11	0.0034965034965035	3146	8202	5141,5534,808,5533,5532,5499,5144,5566,5528,5567,5519	PDE4A,PPP3R1,CALM3,PPP3CC,PPP3CB,PPP1CA,PDE4D,PRKACA,PPP2R5D,PRKACB,PPP2R1B
R-HSA-375165	NCAM signaling for neurite out-growth	0.474049563361178	-0.746443398700382	266	103	0.0327399872854418	3146	8202	161742,10142,685,200734,9462,4763,5683,5786,8826,5894,5037,5604,2064,5720,785,5519,5906,5696,5687,6464,5688,6711,5701,10213,23198,7414,10818,7311,9978,5695,8452,1742,283455,1846,2260,8660,5529,817,2534,5719,6233,5706,80824,5709,4296,4254,5527,5690,784,5705,5536,9861,409,5594,5700,5528,5711,5689,1844,5693,673,5245,8649,5713,808,5716,10256,9252,5715,9491,1847,5708,783,1291,3717,5717,2065,7314,5686,5694,6709,1843,5692,6654,8913,5702,5908,8437,5747,5710,5605,5685,5691,7316,5921,5595,5704,2885,84078,2069,152559,84292,3265	SPRED1,AKAP9,BTC,SPRED2,RASAL2,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,PSME1,CACNB4,PPP2R1B,RAP1A,PSMB8,PSMA6,SHC1,PSMA7,SPTBN1,PSMC2,PSMD14,PSME4,VCL,FRS2,UBA52,RBX1,PSMB7,CUL3,DLG4,KSR2,DUSP4,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,PSMD13,RPS27A,PSMC6,DUSP16,PSMD3,MAP3K11,KITLG,PPP2R5C,PSMB2,CACNB3,PSMC5,PPP5C,PSMD6,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,PSMB1,DUSP2,PSMB5,BRAF,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,RPS6KA5,PSMD9,PSMF1,DUSP5,PSMD2,CACNB2,COL6A1,JAK2,PSMD11,ERBB3,UBB,PSMA5,PSMB6,SPTAN1,DUSP1,PSMB4,SOS1,CACNA1G,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,KBTBD7,EREG,PAQR3,WDR83,HRAS
R-HSA-5666185	RHO GTPases Activate Rhotekin and Rhophilins	0.475956090179466	-0.742429676527912	9	4	0.00127145581691036	3146	8202	30851,387,389,388	TAX1BP3,RHOA,RHOC,RHOB
R-HSA-2243919	Crosslinking of collagen fibrils	0.475956090179466	-0.742429676527912	9	4	0.00127145581691036	3146	8202	7092,84695,4015,7093	TLL1,LOXL3,LOX,TLL2
R-HSA-426486	Small interfering RNA (siRNA) biogenesis	0.475956090179466	-0.742429676527912	9	4	0.00127145581691036	3146	8202	8575,192669,23405,6895	PRKRA,AGO3,DICER1,TARBP2
R-HSA-73614	Pyrimidine salvage reactions	0.475956090179466	-0.742429676527912	9	4	0.00127145581691036	3146	8202	1890,1633,7378,7084	TYMP,DCK,UPP1,TK2
R-HSA-727802	Transport of nucleotide sugars	0.475956090179466	-0.742429676527912	9	4	0.00127145581691036	3146	8202	55343,11046,347734,23443	SLC35C1,SLC35D2,SLC35B2,SLC35A3
R-HSA-196025	Formation of annular gap junctions	0.475956090179466	-0.742429676527912	9	4	0.00127145581691036	3146	8202	1173,8218,1213,1785	AP2M1,CLTCL1,CLTC,DNM2
R-HSA-2428933	SHC-related events triggered by IGF1R	0.475956090179466	-0.742429676527912	9	4	0.00127145581691036	3146	8202	2885,6464,6654,3265	GRB2,SHC1,SOS1,HRAS
R-HSA-2892247	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	0.48236966113019	-0.729044527068082	22	9	0.00286077558804832	3146	8202	5432,5438,5436,5441,5440,5434,5433,6774,5430	POLR2C,POLR2I,POLR2G,POLR2L,POLR2K,POLR2E,POLR2D,STAT3,POLR2A
R-HSA-432720	Lysosome Vesicle Biogenesis	0.484161507426308	-0.72533673489908	35	14	0.00445009535918627	3146	8202	11154,8905,8673,1213,10717,8907,1785,8906,375,9179,130340,23431,164,81567	AP4S1,AP1S2,VAMP8,CLTC,AP4B1,AP1M1,DNM2,AP1G2,ARF1,AP4M1,AP1S3,AP4E1,AP1G1,TXNDC5
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	0.496175517546143	-0.700825548832575	17	7	0.00222504767959313	3146	8202	10392,10454,23118,257397,7867,5608,5606	NOD1,TAB1,TAB2,TAB3,MAPKAPK3,MAP2K6,MAP2K3
R-HSA-189445	Metabolism of porphyrins	0.496175517546143	-0.700825548832575	17	7	0.00222504767959313	3146	8202	644,7390,210,5498,1371,7389,211	BLVRA,UROS,ALAD,PPOX,CPOX,UROD,ALAS1
R-HSA-77289	Mitochondrial Fatty Acid Beta-Oxidation	0.496175517546143	-0.700825548832575	17	7	0.00222504767959313	3146	8202	84693,5096,80724,1632,166785,1892,3032	MCEE,PCCB,ACAD10,ECI1,MMAA,ECHS1,HADHB
R-HSA-5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	0.496175517546143	-0.700825548832575	17	7	0.00222504767959313	3146	8202	51330,9020,958,330,115650,329,7186	TNFRSF12A,MAP3K14,CD40,BIRC3,TNFRSF13C,BIRC2,TRAF2
R-HSA-71262	Carnitine synthesis	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	223,55217	ALDH9A1,TMLHE
R-HSA-428542	Regulation of Commissural axon pathfinding by Slit and Robo	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	9353,6091	SLIT2,ROBO1
R-HSA-210455	Astrocytic Glutamate-Glutamine Uptake And Metabolism	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	81539,2752	SLC38A1,GLUL
R-HSA-111448	Activation of NOXA and translocation to mitochondria	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	5366,7027	PMAIP1,TFDP1
R-HSA-194306	Neurophilin interactions with VEGF and VEGFR	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	8829,8828	NRP1,NRP2
R-HSA-6783984	Glycine degradation	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	2653,2731	GCSH,GLDC
R-HSA-211163	AKT-mediated inactivation of FOXO1A	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	207,208	AKT1,AKT2
R-HSA-75896	Plasmalogen biosynthesis	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	84188,8443	FAR1,GNPAT
R-HSA-110381	Resolution of AP sites via the single-nucleotide replacement pathway	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	3980,328	LIG3,APEX1
R-HSA-209563	Axonal growth stimulation	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	387,396	RHOA,ARHGDIA
R-HSA-433692	Proton-coupled monocarboxylate transport	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	6566,9123	SLC16A1,SLC16A3
R-HSA-196819	Vitamin B1 (thiamin) metabolism	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	10560,27010	SLC19A2,TPK1
R-HSA-75108	Activation, myristolyation of BID and translocation to mitochondria	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	4836,841	NMT1,CASP8
R-HSA-173107	Binding and entry of HIV virion	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	7852,5478	CXCR4,PPIA
R-HSA-442745	Activation of CaMK IV	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	808,814	CALM3,CAMK4
R-HSA-167060	NGF processing	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	5045,5125	FURIN,PCSK5
R-HSA-112313	Neurotransmitter uptake and Metabolism In Glial Cells	0.496236309308931	-0.700703035655647	4	2	0.000635727908455181	3146	8202	81539,2752	SLC38A1,GLUL
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.499638107113362	-0.693871228392602	77	30	0.00953591862682772	3146	8202	3015,8367,10524,3008,1026,8368,898,8360,8365,121504,54386,8294,3012,890,8334,65057,8366,8364,26277,3009,3014,4361,1027,23523,3159,8345,8338,7013,8331,25842	H2AFZ,HIST1H4E,KAT5,HIST1H1E,CDKN1A,HIST1H4L,CCNE1,HIST1H4D,HIST1H4H,HIST4H4,TERF2IP,HIST1H4I,HIST1H2AE,CCNA2,HIST1H2AC,ACD,HIST1H4B,HIST1H4C,TINF2,HIST1H1B,H2AFX,MRE11A,CDKN1B,CABIN1,HMGA1,HIST1H2BH,HIST2H2AC,TERF1,HIST1H2AJ,ASF1A
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	0.500989150367788	-0.691170834084284	64	25	0.00794659885568976	3146	8202	8352,8968,3015,8367,8358,8350,8368,8357,8360,23028,8365,121504,8294,3012,8334,8366,8364,8351,3014,653604,8345,3020,8338,8331,8354	HIST1H3C,HIST1H3F,H2AFZ,HIST1H4E,HIST1H3B,HIST1H3A,HIST1H4L,HIST1H3H,HIST1H4D,KDM1A,HIST1H4H,HIST4H4,HIST1H4I,HIST1H2AE,HIST1H2AC,HIST1H4B,HIST1H4C,HIST1H3D,H2AFX,HIST2H3D,HIST1H2BH,H3F3A,HIST2H2AC,HIST1H2AJ,HIST1H3I
R-HSA-168256	Immune System	0.508296842868029	-0.676689665707277	1371	526	0.167196439923713	3146	8202	71,7249,85363,9666,6777,3606,80176,1387,8907,1785,4361,9972,10097,5094,26259,64223,7311,8905,56992,127544,5335,64145,5719,1398,6233,3984,4296,684,2932,527,2549,3146,5689,171568,9039,30849,1660,3693,5715,4641,966,7337,8878,5601,5598,79902,23191,83547,10112,4651,7867,5702,1974,715,4591,140461,5685,10273,1845,160,3708,10109,6197,5599,2033,685,200734,90933,26052,523,10096,8835,348995,5566,8411,55182,5610,6672,7706,79876,835,57122,10213,51434,253260,64219,140460,1386,5970,9550,4599,2931,5441,3326,535,2260,56658,8660,3796,6049,5529,29927,148022,5536,23112,1844,1173,7186,8672,2923,567,80143,9354,9491,9883,26273,5708,1075,10075,117145,26046,11059,89910,7314,4214,80329,5694,6709,5170,7128,5609,5295,5710,7316,57761,81930,10392,100507436,6776,93611,3685,23321,81559,79654,3709,1026,329,5606,6196,1499,3572,5296,51517,5701,51619,23295,3459,147179,1977,140459,55176,10616,9978,9140,7335,1981,60,3838,80128,5693,3958,5245,26118,8649,5713,3831,10256,5532,8519,1154,7408,92912,9246,5062,8139,51606,5686,10621,10892,10552,1982,10458,3663,5704,996,5434,2069,27338,5337,2537,114609,10142,5071,8655,5604,2064,4067,4193,5687,55845,197131,3551,4940,717,10768,10802,79465,6923,51428,207,330,7879,991,9631,118424,8021,5903,7336,5709,4343,1175,1781,51665,25831,257397,5716,79109,375,55070,51465,6737,3320,9730,3837,7327,1843,29110,5692,4303,5591,6502,23087,55236,11128,3840,7726,51382,23308,11065,63891,84727,23511,5589,8722,6890,8454,5720,55740,9867,51728,5519,6786,63916,10193,5688,3660,163,54778,10818,81929,208,842,25970,1675,3688,5527,4254,642,409,51433,3636,1958,5440,7410,80196,129401,811,5581,10092,23545,51330,970,84282,54926,4277,8437,5908,830,5605,5691,5921,10425,7520,22872,5534,64135,9604,6416,3659,161742,9462,5894,8826,5037,5879,1147,598,29126,5495,1399,6464,10628,115,1027,6891,103,7321,841,10484,8452,1742,3710,8697,7297,6773,817,2534,1650,9474,7334,1783,5711,55593,6396,673,51191,9252,2309,3105,7341,25,5781,6047,79659,2065,9020,6654,29882,7525,5747,3832,10671,10427,51128,997,3569,51444,51752,23376,84292,170506,23291,8936,4763,5786,55585,65264,11004,30011,64682,5696,5906,9775,51135,51529,51343,10393,7220,3835,55703,529,3556,25820,5567,3841,4690,11274,83737,283455,1535,1213,80263,2185,5690,27297,51130,5705,8992,5528,5700,7323,11258,10120,9871,26272,140462,808,814,4205,1847,23165,829,84876,9690,9114,10152,51295,6921,7324,9636,11127,7534,23636,192669,10163,5817,7317,2475,5683,55284,3661,821,8651,6711,23198,8503,4791,7414,4215,115650,5777,5695,958,1846,837,23352,9021,3839,10312,53840,5706,23118,6778,8976,80824,10477,9861,5594,79155,57154,10454,9320,8480,5966,89953,8887,3430,10093,24145,3799,466,27252,9632,51164,10010,25939,10612,5717,3717,130340,6774,8398,6199,6868,3164,7332,84265,7328,3454,64750,10333,5595,2885,7175,10910,5608,8453,7322,84078,23220,152559,528,9533,4793,164,3265	ACTG1,TSC2,TRIM5,DZIP3,STAT5B,IL18,SPSB1,CREBBP,AP1M1,DNM2,MRE11A,NUP153,ACTR2,PCBP2,FBXW8,MLST8,UBA52,AP1S2,KIF15,RNF19B,PLCG1,RBSN,PSMD13,CRK,RPS27A,LIMK1,MAP3K11,BST2,GSK3B,ATP6V0C,GAB1,HMGB1,PSMB1,POLR3H,UBA3,PIK3R4,DHX9,ITGB5,PSMD9,MYO1C,CD59,UBE3A,SQSTM1,MAPK9,MAPK7,NUP85,CYFIP1,RILP,KIF20A,MYO10,MAPKAPK3,PSMC3,EIF4A2,C1R,TRIM37,ASB8,PSMA4,STUB1,DUSP3,AP2A1,ITPR1,ARPC2,RPS6KA3,MAPK8,EP300,BTC,SPRED2,TRIM41,DNM3,ATP6V1A,ACTR3,SOCS2,NUP43,PRKACA,EEA1,RNF220,EIF2AK2,SP100,TRIM25,UBA5,CASP2,NUP107,PSMD14,ANAPC7,RICTOR,PJA1,ASB7,ATF2,RELA,ATP6V1G1,MX1,GSK3A,POLR2L,HSP90AB1,ATP6V0A1,FGFR1,TRIM39,IRS2,KIF2A,RNF6,PPP2R5E,SEC61A1,TICAM1,PPP5C,TNRC6B,DUSP2,AP2M1,TRAF2,EIF4G3,PDIA3,B2M,SIKE1,UBE4A,PSMF1,POM121,FBXO3,PSMD2,CTSC,HUWE1,THEM4,LTN1,WWP1,UBE3B,UBB,MAP3K1,ULBP1,PSMB6,SPTAN1,PDPK1,TNFAIP3,MAP2K7,PIK3R1,PSMD4,UBC,TRIB3,KIF18A,NOD1,MICA,STAT5A,FBXO44,ITGAV,TRIM2,TRIM11,HECTD3,ITPR2,CDKN1A,BIRC2,MAP2K3,RPS6KA2,CTNNB1,IL6ST,PIK3R2,NCKIPSD,PSMC2,UBE2D4,MGRN1,IFNGR1,WIPF2,EIF4E,ASB6,SEC61A2,RBCK1,RBX1,ATG12,UBE2V1,EIF4G1,ACTB,KPNA2,TRIM46,PSMB5,LGALS3,PHB,WSB1,LAMTOR3,PSMD7,KLC1,CNKSR1,PPP3CB,IFITM1,CISH,VASP,UBE2Q2,UBE2L6,PAK2,GAN,ATP6V1H,PSMA5,POLR3F,MALT1,ARPC1A,EIF4G2,BAIAP2,IRF5,PSMC4,CDC27,POLR2E,EREG,UBE2S,PLD1,IFI6,TIRAP,AKAP9,PARK2,DYNLL1,MAP2K1,ERBB2,LYN,MDM2,PSMA6,BRK1,UBR1,IKBKB,OAS3,C2,AHCYL1,SEC24A,ULBP3,TCEB2,DDX41,AKT1,BIRC3,RAB7A,CDC20,NUP155,UBE2J2,NUP214,RANBP2,UBE2V2,PSMD3,MOV10,AP2S1,DYNC1I2,ASB1,HECTD1,TAB3,PSMD10,MAPKAP1,ARF1,DET1,UBE2J1,TRIM21,HSP90AA1,VPRBP,KPNB1,UBE2G2,DUSP1,TBK1,PSMB4,FOXO4,PRKDC,SKP2,TRIM35,UBA6,POLR3A,KPNA4,TRIM26,ATP6V1D,ICOSLG,UBE2C,RNF123,SPSB2,NUP188,PRKCSH,CTSF,TAP1,CUL1,PSME1,ENAH,PJA2,POLR3K,PPP2R1B,STIM1,ELMO2,RNF41,PSMA7,IRF2,AP2B1,RNF111,FRS2,SEH1L,AKT2,CASP9,SH2B1,CFD,ITGB1,PPP2R5C,KITLG,BLMH,ARRB2,ANAPC5,INPPL1,EGR1,POLR2K,VAV2,RNF34,NUP35,CALR,PRKCE,ARPC5,ATP6V0A2,TNFRSF12A,CD70,RNF135,UBE2R2,MICB,RASAL1,RAP1B,CAPZA2,MAP2K2,PSMB3,RASA1,ARIH2,XRCC5,SEC31A,PPP3R1,IFIH1,RNF14,MAP2K4,IRF1,SPRED1,RASAL2,RAF1,IQGAP1,PEBP1,RAC1,CHUK,BCL2L1,CD274,PPM1B,CRKL,SHC1,TXNIP,ADCY9,CDKN1B,TAP2,ADAR,UBE2D1,CASP8,SEC23A,CUL3,DLG4,ITPR3,CDC23,TYK2,STAT2,CAMK2D,FYN,DDOST,ATG5,UBE2N,DYNC1LI2,PSMD5,OTUD5,SEC13,BRAF,HERC5,RPS6KA5,FOXO3,HLA-A,SUMO1,ABL1,PTPN11,RNF4,DYNC2H1,ERBB3,MAP3K14,SOS1,ANAPC2,YES1,PTK2,KIF11,DCTN6,SEC24B,SAR1B,CDC34,IL6,RNF138,ERAP1,UFL1,WDR83,DHX36,FBXW11,WASF1,NF1,PTPRA,UBE2Q1,UBE2Z,KIF2C,SH3KBP1,ANAPC1,PSMB8,RAP1A,EIF4A3,IRAK4,ANAPC11,FZR1,ANAPC10,TRPC1,KIF22,POLR3B,ATP6V1E1,IL1RAP,ARIH1,PRKACB,KPNA5,NCK1,USP18,ITCH,KSR2,CYBA,CLTC,TRIM45,PTK2B,PSMB2,CRCP,ASB3,PSMC5,ATP6V0E1,PPP2R5D,PSMC1,UBE2D3,DCTN3,ACTR1B,SEC24D,FBXO4,ASB9,CALM3,CAMK4,MEF2A,DUSP5,NUP205,CAPZA1,ORAI1,UBE3C,ATP6V0D1,ABI2,ECSIT,TCEB1,UBE2E1,ISG15,KIF3A,YWHAZ,NUP62,AGO3,WASF2,PVR,UBA1,MTOR,PSMA2,UBE2W,IRF3,CANX,SOCS1,SPTBN1,PSME4,PIK3R3,NFKB2,VCL,MAP3K3,TNFRSF13C,PTPN6,PSMB7,CD40,DUSP4,CASP4,UBR4,SOCS3,KPNA3,TCIRG1,TRIM34,PSMC6,TAB2,STAT6,WASL,DUSP16,UBE2E3,PSMD6,MAPK1,TNIP2,SMURF1,TAB1,TRIP12,RAE1,REL,KLC4,TAX1BP1,IFI35,ARPC4,PANX1,KIF5B,ATF1,KLHL20,SEC24C,DCTN4,TANK,SAMHD1,TRIM3,PSMD11,JAK2,AP1S3,STAT3,PLA2G6,RPS6KB2,ADAM17,NR4A1,UBE2L3,POLR3GL,UBE2H,IFNAR1,SMURF2,TLR6,MAPK3,GRB2,TPR,SUGT1,MAP2K6,CUL2,UBE2D2,KBTBD7,DTX4,PAQR3,ATP6V1C1,POLR1C,NFKBIB,AP1G1,HRAS
R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.5146709588426	-0.664227497380223	12	5	0.00158931977113795	3146	8202	5558,5422,5519,7027,5557	PRIM2,POLA1,PPP2R1B,TFDP1,PRIM1
R-HSA-933541	TRAF6 mediated IRF7 activation	0.516921180741465	-0.659864871141682	33	13	0.00413223140495868	3146	8202	2033,1387,29110,7706,7186,10010,3660,80143,3661,84282,64135,170506,3659	EP300,CREBBP,TBK1,TRIM25,TRAF2,TANK,IRF2,SIKE1,IRF3,RNF135,IFIH1,DHX36,IRF1
R-HSA-1221632	Meiotic synapsis	0.52177078368806	-0.650526899245974	75	29	0.00921805467260013	3146	8202	25777,3015,10274,8367,23224,256126,10735,672,11083,8368,8360,4000,8365,121504,54386,8294,3012,9126,8334,65057,8366,8364,26277,8243,3014,8345,8338,7013,8331	SUN2,H2AFZ,STAG1,HIST1H4E,SYNE2,SYCE2,STAG2,BRCA1,DIDO1,HIST1H4L,HIST1H4D,LMNA,HIST1H4H,HIST4H4,TERF2IP,HIST1H4I,HIST1H2AE,SMC3,HIST1H2AC,ACD,HIST1H4B,HIST1H4C,TINF2,SMC1A,H2AFX,HIST1H2BH,HIST2H2AC,TERF1,HIST1H2AJ
R-HSA-442755	Activation of NMDA receptor upon glutamate binding and postsynaptic events	0.524005464150453	-0.646253166947423	41	16	0.00508582326764145	3146	8202	5170,817,10142,673,6196,6237,84254,5894,808,814,1742,5594,5566,3265,5567,6197	PDPK1,CAMK2D,AKAP9,BRAF,RPS6KA2,RRAS,CAMKK1,RAF1,CALM3,CAMK4,DLG4,MAPK1,PRKACA,HRAS,PRKACB,RPS6KA3
R-HSA-3000170	Syndecan interactions	0.524084541104201	-0.646102269689552	20	8	0.00254291163382072	3146	8202	8573,3673,3688,87,3685,3693,6382,7057	CASK,ITGA2,ITGB1,ACTN1,ITGAV,ITGB5,SDC1,THBS1
R-HSA-171306	Packaging Of Telomere Ends	0.530031813885244	-0.634818248038896	49	19	0.00603941513032422	3146	8202	3015,8367,8368,8360,8365,121504,54386,8294,8334,3012,65057,8366,8364,26277,3014,8345,8338,7013,8331	H2AFZ,HIST1H4E,HIST1H4L,HIST1H4D,HIST1H4H,HIST4H4,TERF2IP,HIST1H4I,HIST1H2AC,HIST1H2AE,ACD,HIST1H4B,HIST1H4C,TINF2,H2AFX,HIST1H2BH,HIST2H2AC,TERF1,HIST1H2AJ
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding	0.531056562749066	-0.632886742228494	28	11	0.0034965034965035	3146	8202	22948,10576,7280,6950,7411,10383,7203,60,10471,5201,10381	CCT5,CCT2,TUBB2A,TCP1,VBP1,TUBB4B,CCT3,ACTB,PFDN6,PFDN1,TUBB3
R-HSA-3656534	Loss of Function of TGFBR1 in Cancer	0.543897753959423	-0.608994002071911	7	3	0.000953591862682772	3146	8202	4088,4087,9372	SMAD3,SMAD2,ZFYVE9
R-HSA-435368	Zinc efflux and compartmentalization by the SLC30 family	0.543897753959423	-0.608994002071911	7	3	0.000953591862682772	3146	8202	7779,55676,148867	SLC30A1,SLC30A6,SLC30A7
R-HSA-162791	Attachment of GPI anchor to uPAR	0.543897753959423	-0.608994002071911	7	3	0.000953591862682772	3146	8202	8733,10026,80055	GPAA1,PIGK,PGAP1
R-HSA-163767	PP2A-mediated dephosphorylation of key metabolic factors	0.543897753959423	-0.608994002071911	7	3	0.000953591862682772	3146	8202	51085,5528,5519	MLXIPL,PPP2R5D,PPP2R1B
R-HSA-74182	Ketone body metabolism	0.543897753959423	-0.608994002071911	7	3	0.000953591862682772	3146	8202	38,3155,65985	ACAT1,HMGCL,AACS
R-HSA-448706	Interleukin-1 processing	0.543897753959423	-0.608994002071911	7	3	0.000953591862682772	3146	8202	3606,4791,5970	IL18,NFKB2,RELA
R-HSA-3656532	TGFBR1 KD Mutants in Cancer	0.543897753959423	-0.608994002071911	7	3	0.000953591862682772	3146	8202	4088,4087,9372	SMAD3,SMAD2,ZFYVE9
R-HSA-2214320	Anchoring fibril formation	0.543897753959423	-0.608994002071911	7	3	0.000953591862682772	3146	8202	1294,7092,7093	COL7A1,TLL1,TLL2
R-HSA-2142789	Ubiquinol biosynthesis	0.543897753959423	-0.608994002071911	7	3	0.000953591862682772	3146	8202	84274,51805,23590	COQ5,COQ3,PDSS1
R-HSA-180292	GAB1 signalosome	0.547762544840927	-0.601913398275115	102	39	0.012396694214876	3146	8202	23112,685,7249,2475,79109,2064,1147,1026,2309,4193,5296,117145,5781,8503,1027,253260,2065,10818,64223,6199,5170,207,2931,4303,3164,208,5295,842,2260,2885,8660,57761,2534,2069,4254,2932,4343,2549,192669	TNRC6B,BTC,TSC2,MTOR,MAPKAP1,ERBB2,CHUK,CDKN1A,FOXO3,MDM2,PIK3R2,THEM4,PTPN11,PIK3R3,CDKN1B,RICTOR,ERBB3,FRS2,MLST8,RPS6KB2,PDPK1,AKT1,GSK3A,FOXO4,NR4A1,AKT2,PIK3R1,CASP9,FGFR1,GRB2,IRS2,TRIB3,FYN,EREG,KITLG,GSK3B,MOV10,GAB1,AGO3
R-HSA-352230	Amino acid transport across the plasma membrane	0.551682536169655	-0.594782513782156	31	12	0.00381436745073109	3146	8202	6541,6533,6520,6509,23657,81539,206358,6510,124935,9057,117247,8501	SLC7A1,SLC6A6,SLC3A2,SLC1A4,SLC7A11,SLC38A1,SLC36A1,SLC1A5,SLC43A2,SLC7A6,SLC16A10,SLC43A1
R-HSA-373760	L1CAM interactions	0.555788629081839	-0.587367220533898	97	37	0.0117609663064209	3146	8202	26052,1173,7410,5879,5604,9252,8828,6196,6324,1808,6711,1739,1785,163,8986,1741,6709,3915,287,1742,3678,7430,214,10048,5605,2260,5595,100133941,160,3673,3688,3685,8829,5594,1175,8650,6197	DNM3,AP2M1,VAV2,RAC1,MAP2K1,RPS6KA5,NRP2,RPS6KA2,SCN1B,DPYSL2,SPTBN1,DLG1,DNM2,AP2B1,RPS6KA4,DLG3,SPTAN1,LAMC1,ANK2,DLG4,ITGA5,EZR,ALCAM,RANBP9,MAP2K2,FGFR1,MAPK3,CD24,AP2A1,ITGA2,ITGB1,ITGAV,NRP1,MAPK1,AP2S1,NUMB,RPS6KA3
R-HSA-912446	Meiotic recombination	0.561078233948225	-0.577894928729145	84	32	0.0101716465352829	3146	8202	8352,8968,3015,8367,29893,8358,8350,11144,672,641,8368,8357,8360,8365,121504,8294,5889,3012,8334,5888,8366,8364,8351,3014,4361,653604,8345,4438,3020,8338,8331,8354	HIST1H3C,HIST1H3F,H2AFZ,HIST1H4E,PSMC3IP,HIST1H3B,HIST1H3A,DMC1,BRCA1,BLM,HIST1H4L,HIST1H3H,HIST1H4D,HIST1H4H,HIST4H4,HIST1H4I,RAD51C,HIST1H2AE,HIST1H2AC,RAD51,HIST1H4B,HIST1H4C,HIST1H3D,H2AFX,MRE11A,HIST2H3D,HIST1H2BH,MSH4,H3F3A,HIST2H2AC,HIST1H2AJ,HIST1H3I
R-HSA-264876	Insulin processing	0.569452878907661	-0.563079240681157	26	10	0.00317863954227591	3146	8202	3799,56605,55676,30001,60412,149371,55770,23265,10640,148867	KIF5B,ERO1B,SLC30A6,ERO1A,EXOC4,EXOC8,EXOC2,EXOC7,EXOC5,SLC30A7
R-HSA-2029485	Role of phospholipids in phagocytosis	0.569452878907661	-0.563079240681157	26	10	0.00317863954227591	3146	8202	5581,5335,5296,3708,5295,3709,5337,10768,3710,8398	PRKCE,PLCG1,PIK3R2,ITPR1,PIK3R1,ITPR2,PLD1,AHCYL1,ITPR3,PLA2G6
R-HSA-5635838	Activation of SMO	0.570083575720742	-0.561972304830322	18	7	0.00222504767959313	3146	8202	11127,5727,409,1452,23288,2619,2622	KIF3A,PTCH1,ARRB2,CSNK1A1,IQCE,GAS1,GAS8
R-HSA-3296482	Defects in vitamin and cofactor metabolism	0.570083575720742	-0.561972304830322	18	7	0.00222504767959313	3146	8202	25974,5096,5091,166785,31,4552,56922	MMACHC,PCCB,PC,MMAA,ACACA,MTRR,MCCC1
R-HSA-1222556	ROS production in response to bacteria	0.570432443586042	-0.561360532842424	34	13	0.00413223140495868	3146	8202	51382,10312,1535,523,535,23545,527,528,51606,529,9114,8992,9550	ATP6V1D,TCIRG1,CYBA,ATP6V1A,ATP6V0A1,ATP6V0A2,ATP6V0C,ATP6V1C1,ATP6V1H,ATP6V1E1,ATP6V0D1,ATP6V0E1,ATP6V1G1
R-HSA-74259	Purine catabolism	0.575777812089806	-0.552033435603819	10	4	0.00127145581691036	3146	8202	847,30833,4860,2876	CAT,NT5C,PNP,GPX1
R-HSA-2151209	Activation of PPARGC1A (PGC-1alpha) by phosphorylation	0.575777812089806	-0.552033435603819	10	4	0.00127145581691036	3146	8202	5571,51422,10891,5565	PRKAG1,PRKAG2,PPARGC1A,PRKAB2
R-HSA-975144	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	0.575777812089806	-0.552033435603819	10	4	0.00127145581691036	3146	8202	1147,7335,7334,3551	CHUK,UBE2V1,UBE2N,IKBKB
R-HSA-937039	IRAK1 recruits IKK complex	0.575777812089806	-0.552033435603819	10	4	0.00127145581691036	3146	8202	1147,7335,7334,3551	CHUK,UBE2V1,UBE2N,IKBKB
R-HSA-430116	GP1b-IX-V activation signalling	0.575777812089806	-0.552033435603819	10	4	0.00127145581691036	3146	8202	2812,7534,5894,5295	GP1BB,YWHAZ,RAF1,PIK3R1
R-HSA-1855167	Synthesis of pyrophosphates in the cytosol	0.575777812089806	-0.552033435603819	10	4	0.00127145581691036	3146	8202	64768,11163,9807,11165	IPPK,NUDT4,IP6K1,NUDT3
R-HSA-418889	Ligand-independent caspase activation via DCC	0.575777812089806	-0.552033435603819	10	4	0.00127145581691036	3146	8202	836,26060,842,1613	CASP3,APPL1,CASP9,DAPK3
R-HSA-5668914	Diseases of metabolism	0.587855535816372	-0.531274048656723	45	17	0.00540368722186904	3146	8202	25974,5096,7311,56922,5507,3417,7270,166785,2230,7316,4552,5091,112812,6233,2232,7314,31	MMACHC,PCCB,UBA52,MCCC1,PPP1R3C,IDH1,TTF1,MMAA,FDX1,UBC,MTRR,PC,FDX1L,RPS27A,FDXR,UBB,ACACA
R-HSA-1226099	Signaling by FGFR in disease	0.587855535816372	-0.531274048656723	45	17	0.00540368722186904	3146	8202	11116,8805,6654,5295,1523,6777,2260,2885,5335,399687,6776,6774,11052,2549,10818,3265,26127	FGFR1OP,TRIM24,SOS1,PIK3R1,CUX1,STAT5B,FGFR1,GRB2,PLCG1,MYO18A,STAT5A,STAT3,CPSF6,GAB1,FRS2,HRAS,FGFR1OP2
R-HSA-5654732	Negative regulation of FGFR3 signaling	0.588468315437494	-0.530232193259678	29	11	0.0034965034965035	3146	8202	2885,7311,673,6233,5781,7314,5594,10253,10818,7316,5595	GRB2,UBA52,BRAF,RPS27A,PTPN11,UBB,MAPK1,SPRY2,FRS2,UBC,MAPK3
R-HSA-4086398	Ca2+ pathway	0.589884344561757	-0.527828787464526	61	23	0.00731087094723458	3146	8202	23112,2785,8322,7976,51701,2782,808,7481,5532,3709,2535,3710,2783,6934,7474,10681,1499,59345,3708,5534,7855,4343,192669	TNRC6B,GNG3,FZD4,FZD3,NLK,GNB1,CALM3,WNT11,PPP3CB,ITPR2,FZD2,ITPR3,GNB2,TCF7L2,WNT5A,GNB5,CTNNB1,GNB4,ITPR1,PPP3R1,FZD5,MOV10,AGO3
R-HSA-2022870	Chondroitin sulfate biosynthesis	0.591570771864257	-0.524973954598803	21	8	0.00254291163382072	3146	8202	50515,55501,51363,9469,22856,54480,10675,55454	CHST11,CHST12,CHST15,CHST3,CHSY1,CHPF2,CSPG5,CSGALNACT2
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	0.591570771864257	-0.524973954598803	21	8	0.00254291163382072	3146	8202	3146,3551,1660,148022,1147,4791,4793,5970	HMGB1,IKBKB,DHX9,TICAM1,CHUK,NFKB2,NFKBIB,RELA
R-HSA-1502540	Signaling by Activin	0.600422735777872	-0.51012131222182	13	5	0.00158931977113795	3146	8202	4088,92,4087,4089,10272	SMAD3,ACVR2A,SMAD2,SMAD4,FSTL3
R-HSA-174403	Glutathione synthesis and recycling	0.600422735777872	-0.51012131222182	13	5	0.00158931977113795	3146	8202	26873,79017,55748,2729,2937	OPLAH,GGCT,CNDP2,GCLC,GSS
R-HSA-171007	p38MAPK events	0.600422735777872	-0.51012131222182	13	5	0.00158931977113795	3146	8202	5900,5898,5899,7867,3265	RALGDS,RALA,RALB,MAPKAPK3,HRAS
R-HSA-3134963	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	0.600422735777872	-0.51012131222182	13	5	0.00158931977113795	3146	8202	3146,4791,5970,170506,1660	HMGB1,NFKB2,RELA,DHX36,DHX9
R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels	0.600422735777872	-0.51012131222182	13	5	0.00158931977113795	3146	8202	11094,784,785,783,781	CACFD1,CACNB3,CACNB4,CACNB2,CACNA2D1
R-HSA-75892	Platelet Adhesion to exposed collagen	0.600422735777872	-0.51012131222182	13	5	0.00158931977113795	3146	8202	2812,2534,4067,3673,3688	GP1BB,FYN,LYN,ITGA2,ITGB1
R-HSA-5654726	Negative regulation of FGFR1 signaling	0.605681827690266	-0.501400467607658	32	12	0.00381436745073109	3146	8202	2885,7311,673,6233,5781,7314,5594,10253,10818,2260,7316,5595	GRB2,UBA52,BRAF,RPS27A,PTPN11,UBB,MAPK1,SPRY2,FRS2,FGFR1,UBC,MAPK3
R-HSA-5602358	Diseases associated with the TLR signaling cascade	0.610423654851904	-0.493602046728851	24	9	0.00286077558804832	3146	8202	51135,3551,148022,1147,4793,4791,5970,10333,114609	IRAK4,IKBKB,TICAM1,CHUK,NFKBIB,NFKB2,RELA,TLR6,TIRAP
R-HSA-379716	Cytosolic tRNA aminoacylation	0.610423654851904	-0.493602046728851	24	9	0.00286077558804832	3146	8202	833,2193,5917,3735,2617,3376,7407,7965,16	CARS,FARSA,RARS,KARS,GARS,IARS,VARS,AIMP2,AARS
R-HSA-5260271	Diseases of Immune System	0.610423654851904	-0.493602046728851	24	9	0.00286077558804832	3146	8202	51135,3551,148022,1147,4793,4791,5970,10333,114609	IRAK4,IKBKB,TICAM1,CHUK,NFKBIB,NFKB2,RELA,TLR6,TIRAP
R-HSA-383280	Nuclear Receptor transcription pathway	0.616421213641545	-0.483824760746243	51	19	0.00603941513032422	3146	8202	5915,7068,5914,5468,2908,3164,6256,5465,2100,7376,7025,6257,5467,2101,5469,29959,5916,4306,126382	RARB,THRB,RARA,PPARG,NR3C1,NR4A1,RXRA,PPARA,ESR2,NR1H2,NR2F1,RXRB,PPARD,ESRRA,MED1,NRBP1,RARG,NR3C2,NR2C2AP
R-HSA-1483255	PI Metabolism	0.616421213641545	-0.483824760746243	51	19	0.00603941513032422	3146	8202	3636,5295,30849,5297,375,8394,8898,55697,55361,8396,5298,9110,4952,5296,377,22908,8503,9896,200576	INPPL1,PIK3R1,PIK3R4,PI4KA,ARF1,PIP5K1A,MTMR2,VAC14,PI4K2A,PIP4K2B,PI4KB,MTMR4,OCRL,PIK3R2,ARF3,SACM1L,PIK3R3,FIG4,PIKFYVE
R-HSA-68881	Mitotic Metaphase/Anaphase Transition	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	26271	FBXO5
R-HSA-69560	Transcriptional activation of p53 responsive genes	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	1026	CDKN1A
R-HSA-192905	vRNP Assembly	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	3320	HSP90AA1
R-HSA-5652227	Fructose biosynthesis	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	231	AKR1B1
R-HSA-3359469	Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	4552	MTRR
R-HSA-75102	C6 deamination of adenosine	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	103	ADAR
R-HSA-5545619	XAV939 inhibits tankyrase, stabilizing AXIN	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	8658	TNKS
R-HSA-1614603	Cysteine formation from homocysteine	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	1491	CTH
R-HSA-69895	Transcriptional  activation of  cell cycle inhibitor p21	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	1026	CDKN1A
R-HSA-75064	mRNA Editing: A to I Conversion	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	103	ADAR
R-HSA-164939	Nef mediated downregulation of CD28 cell surface expression	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	1173	AP2M1
R-HSA-156582	Acetylation	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	9	NAT1
R-HSA-888568	GABA synthesis	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	2571	GAD1
R-HSA-111457	Release of apoptotic factors from the mitochondria	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	56616	DIABLO
R-HSA-428559	Proton-coupled neutral amino acid transporters	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	206358	SLC36A1
R-HSA-165160	PDE3B signalling	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	208	AKT2
R-HSA-3359467	Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	4552	MTRR
R-HSA-203754	NOSIP mediated eNOS trafficking	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	51070	NOSIP
R-HSA-3359478	Defective MUT causes methylmalonic aciduria mut type	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	166785	MMAA
R-HSA-351143	Agmatine biosynthesis	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	113451	AZIN2
R-HSA-3359475	Defective MMAA causes methylmalonic aciduria type cblA	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	166785	MMAA
R-HSA-114294	Activation, translocation and oligomerization of BAX	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	581	BAX
R-HSA-5602566	TICAM1 deficiency - HSE	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	148022	TICAM1
R-HSA-5602636	IKBKB deficiency causes SCID	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	1147	CHUK
R-HSA-73930	Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	328	APEX1
R-HSA-3359473	Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	25974	MMACHC
R-HSA-111995	phospho-PLA2 pathway	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	5594	MAPK1
R-HSA-77042	Formation of editosomes by ADAR proteins	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	103	ADAR
R-HSA-163754	Insulin effects increased synthesis of Xylulose-5-Phosphate	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	6888	TALDO1
R-HSA-111452	Activation and oligomerization of BAK protein	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	578	BAK1
R-HSA-1483226	Synthesis of PI	0.620036702202733	-0.477976605593897	2	1	0.000317863954227591	3146	8202	10423	CDIPT
R-HSA-392517	Rap1 signalling	0.620834791013242	-0.476690269458497	16	6	0.00190718372536554	3146	8202	7534,5906,5566,5894,5567,5908	YWHAZ,RAP1A,PRKACA,RAF1,PRKACB,RAP1B
R-HSA-354192	Integrin alphaIIb beta3 signaling	0.627256293926094	-0.466400059627168	27	10	0.00317863954227591	3146	8202	2885,5170,5906,6464,1398,207,6654,5908,5747,9564	GRB2,PDPK1,RAP1A,SHC1,CRK,AKT1,SOS1,RAP1B,PTK2,BCAR1
R-HSA-77310	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	1892,3032	ECHS1,HADHB
R-HSA-111932	CaMK IV-mediated phosphorylation of CREB	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	814,808	CAMK4,CALM3
R-HSA-5652084	Fructose metabolism	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	231,3795	AKR1B1,KHK
R-HSA-77346	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	1892,3032	ECHS1,HADHB
R-HSA-74713	IRS activation	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	8660,3643	IRS2,INSR
R-HSA-167827	The proton buffering model	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	9016,9481	SLC25A14,SLC25A27
R-HSA-2142850	Hyaluronan biosynthesis and export	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	3038,57214	HAS3,CEMIP
R-HSA-77348	Beta oxidation of octanoyl-CoA to hexanoyl-CoA	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	1892,3032	ECHS1,HADHB
R-HSA-197264	Nicotinamide salvaging	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	5743,93100	PTGS2,NAPRT
R-HSA-166187	Mitochondrial Uncoupling Proteins	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	9016,9481	SLC25A14,SLC25A27
R-HSA-77350	Beta oxidation of hexanoyl-CoA to butanoyl-CoA	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	1892,3032	ECHS1,HADHB
R-HSA-964739	N-glycan trimming and elongation in the cis-Golgi	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	4245,10905	MGAT1,MAN1A2
R-HSA-2644607	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	8454,9978	CUL1,RBX1
R-HSA-112303	Electric Transmission Across Gap Junctions	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	24145,10052	PANX1,GJC1
R-HSA-2644605	FBXW7 Mutants and NOTCH1 in Cancer	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	8454,9978	CUL1,RBX1
R-HSA-68911	G2 Phase	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	890,1871	CCNA2,E2F3
R-HSA-446199	Synthesis of Dolichyl-phosphate	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	79947,22845	DHDDS,DOLK
R-HSA-112307	Transmission across Electrical Synapses	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	24145,10052	PANX1,GJC1
R-HSA-167826	The fatty acid cycling model	0.634126569970275	-0.45550670729267	5	2	0.000635727908455181	3146	8202	9016,9481	SLC25A14,SLC25A27
R-HSA-418360	Platelet calcium homeostasis	0.638424146377544	-0.448752410288724	19	7	0.00222504767959313	3146	8202	84876,3709,488,3710,6786,3708,493	ORAI1,ITPR2,ATP2A2,ITPR3,STIM1,ITPR1,ATP2B4
R-HSA-399719	Trafficking of AMPA receptors	0.64248424651877	-0.442412981550293	30	11	0.0034965034965035	3146	8202	59283,817,4193,1173,160,1739,163,1742,4646,1175,9463	CACNG8,CAMK2D,MDM2,AP2M1,AP2A1,DLG1,AP2B1,DLG4,MYO6,AP2S1,PICK1
R-HSA-399721	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	0.64248424651877	-0.442412981550293	30	11	0.0034965034965035	3146	8202	59283,817,4193,1173,160,1739,163,1742,4646,1175,9463	CACNG8,CAMK2D,MDM2,AP2M1,AP2A1,DLG1,AP2B1,DLG4,MYO6,AP2S1,PICK1
R-HSA-196836	Vitamin C (ascorbate) metabolism	0.649429283015288	-0.431661327913505	8	3	0.000953591862682772	3146	8202	119391,1528,1727	GSTO2,CYB5A,CYB5R3
R-HSA-164944	Nef and signal transduction	0.649429283015288	-0.431661327913505	8	3	0.000953591862682772	3146	8202	2534,5879,5062	FYN,RAC1,PAK2
R-HSA-111453	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	0.649429283015288	-0.431661327913505	8	3	0.000953591862682772	3146	8202	598,10018,5366	BCL2L1,BCL2L11,PMAIP1
R-HSA-1236973	Cross-presentation of particulate exogenous antigens (phagosomes)	0.649429283015288	-0.431661327913505	8	3	0.000953591862682772	3146	8202	3685,1535,3693	ITGAV,CYBA,ITGB5
R-HSA-392170	ADP signalling through P2Y purinoceptor 12	0.653971406546579	-0.424691649357515	22	8	0.00254291163382072	3146	8202	10681,2785,59345,2782,2773,2771,2783,2770	GNB5,GNG3,GNB4,GNB1,GNAI3,GNAI2,GNB2,GNAI1
R-HSA-71064	Lysine catabolism	0.663685822632972	-0.40994640016588	11	4	0.00127145581691036	3146	8202	85007,2639,51166,1743	PHYKPL,GCDH,AADAT,DLST
R-HSA-975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	0.663685822632972	-0.40994640016588	11	4	0.00127145581691036	3146	8202	7335,170506,7334,51135	UBE2V1,DHX36,UBE2N,IRAK4
R-HSA-1855183	Synthesis of IP2, IP, and Ins in the cytosol	0.663685822632972	-0.40994640016588	11	4	0.00127145581691036	3146	8202	3612,51477,4952,3613	IMPA1,ISYNA1,OCRL,IMPA2
R-HSA-196807	Nicotinate metabolism	0.663685822632972	-0.40994640016588	11	4	0.00127145581691036	3146	8202	5743,64802,93100,65220	PTGS2,NMNAT1,NAPRT,NADK
R-HSA-2024101	CS/DS degradation	0.676776850496281	-0.390413675624572	14	5	0.00158931977113795	3146	8202	3373,3423,3073,3425,10675	HYAL1,IDS,HEXA,IDUA,CSPG5
R-HSA-5675482	Regulation of necroptotic cell death	0.676776850496281	-0.390413675624572	14	5	0.00158931977113795	3146	8202	8743,841,330,7186,329	TNFSF10,CASP8,BIRC3,TRAF2,BIRC2
R-HSA-977225	Amyloid formation	0.687941661583232	-0.374051238854444	88	32	0.0101716465352829	3146	8202	8352,8968,3015,8367,26088,23621,4240,5045,8350,567,8358,8368,23062,8357,8360,6622,8365,121504,8294,2934,8334,3012,8366,8351,8364,3014,653604,8345,8338,3020,8331,8354	HIST1H3C,HIST1H3F,H2AFZ,HIST1H4E,GGA1,BACE1,MFGE8,FURIN,HIST1H3A,B2M,HIST1H3B,HIST1H4L,GGA2,HIST1H3H,HIST1H4D,SNCA,HIST1H4H,HIST4H4,HIST1H4I,GSN,HIST1H2AC,HIST1H2AE,HIST1H4B,HIST1H3D,HIST1H4C,H2AFX,HIST2H3D,HIST1H2BH,HIST2H2AC,H3F3A,HIST1H2AJ,HIST1H3I
R-HSA-2142845	Hyaluronan metabolism	0.688830758380568	-0.372759671841569	17	6	0.00190718372536554	3146	8202	6548,3373,3038,3073,57214,11261	SLC9A1,HYAL1,HAS3,HEXA,CEMIP,CHP1
R-HSA-432142	Platelet sensitization by LDL	0.688830758380568	-0.372759671841569	17	6	0.00190718372536554	3146	8202	5527,5529,5528,5777,5519,5781	PPP2R5C,PPP2R5E,PPP2R5D,PTPN6,PPP2R1B,PTPN11
R-HSA-5654733	Negative regulation of FGFR4 signaling	0.692425187205585	-0.367555079672742	31	11	0.0034965034965035	3146	8202	2885,7311,673,6233,5781,7314,5594,10253,10818,7316,5595	GRB2,UBA52,BRAF,RPS27A,PTPN11,UBB,MAPK1,SPRY2,FRS2,UBC,MAPK3
R-HSA-1483191	Synthesis of PC	0.699991626144755	-0.356686906660635	20	7	0.00222504767959313	3146	8202	57153,162466,64900,10400,23446,5130,1119	SLC44A2,PHOSPHO1,LPIN3,PEMT,SLC44A1,PCYT1A,CHKA
R-HSA-163560	Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis	0.699991626144755	-0.356686906660635	20	7	0.00222504767959313	3146	8202	5500,2170,857,5499,5566,5501,5567	PPP1CB,FABP3,CAV1,PPP1CA,PRKACA,PPP1CC,PRKACB
R-HSA-1482839	Acyl chain remodelling of PE	0.71038320771659	-0.341950725369886	23	8	0.00254291163382072	3146	8202	81579,10162,154141,50640,11145,129642,8398,254531	PLA2G12A,LPCAT3,MBOAT1,PNPLA8,PLA2G16,MBOAT2,PLA2G6,LPCAT4
R-HSA-1793185	Chondroitin sulfate/dermatan sulfate metabolism	0.721626848368142	-0.326247104207276	51	18	0.00572155117609663	3146	8202	50515,283464,113189,22856,6382,10675,3423,221914,55501,51363,3373,92126,9469,54480,3073,3425,11285,55454	CHST11,GXYLT1,CHST14,CHSY1,SDC1,CSPG5,IDS,GPC2,CHST12,CHST15,HYAL1,DSEL,CHST3,CHPF2,HEXA,IDUA,B4GALT7,CSGALNACT2
R-HSA-114604	GPVI-mediated activation cascade	0.730365167148374	-0.314210640942128	54	19	0.00603941513032422	3146	8202	5170,391,387,207,208,5777,5879,7410,5295,4067,388,2885,2534,6464,5296,5781,5590,8503,3717	PDPK1,RHOG,RHOA,AKT1,AKT2,PTPN6,RAC1,VAV2,PIK3R1,LYN,RHOB,GRB2,FYN,SHC1,PIK3R2,PTPN11,PRKCZ,PIK3R3,JAK2
R-HSA-168249	Innate Immune System	0.733454557565319	-0.309989636194444	752	281	0.089319771137953	3146	8202	71,7249,5589,8454,5720,51728,5519,1387,63916,5688,1785,3660,4361,10097,10818,5094,64223,7311,208,842,5335,64145,1398,5719,6233,3984,1675,4296,4254,5527,2932,409,2549,3146,5689,5440,171568,9039,7410,30849,1660,5715,4641,5581,966,10092,5601,84282,5598,23191,4651,7867,5702,5908,8437,715,830,5605,5685,5691,5921,7520,1845,3708,5534,10109,64135,6416,6197,3659,5599,2033,685,200734,161742,26052,9462,8826,5894,5037,5879,10096,1147,598,5566,8411,6464,7706,10628,115,835,10213,1027,253260,7321,841,1386,5970,2931,5441,3326,8452,1742,3710,2260,8660,5529,817,2534,1650,148022,9474,5536,7334,5711,55593,23112,1844,673,7186,51191,567,80143,9252,2309,9491,25,5708,117145,5781,2065,9020,7314,4214,5694,6709,5170,7128,5609,6654,5295,5747,7525,5710,7316,57761,10392,997,84292,170506,23291,8936,4763,5786,3709,1026,329,5606,6196,5696,5906,1499,51517,5701,51135,5296,55703,147179,5567,9978,4690,83737,283455,9140,7335,27297,5690,60,5705,5700,5528,7323,5693,3958,5245,5713,8649,808,814,10256,4205,5532,1847,9246,5062,829,5686,10621,10152,51295,10892,10552,9636,10458,5704,5434,2069,5337,192669,114609,10163,10142,2475,5683,5604,2064,3661,4067,5687,4193,8651,55845,6711,3551,23198,8503,4791,717,10768,7414,207,330,51428,5695,1846,837,23118,5706,80824,6778,8976,5709,9861,10454,4343,79155,5594,257397,8887,79109,5716,10093,24145,466,10010,6737,3717,5717,3320,8398,1843,6199,29110,5692,4303,3164,5591,84265,10333,11128,5595,2885,10910,5608,7322,84078,23220,152559,9533,4793,3265	ACTG1,TSC2,PRKCSH,CUL1,PSME1,POLR3K,PPP2R1B,CREBBP,ELMO2,PSMA7,DNM2,IRF2,MRE11A,ACTR2,FRS2,PCBP2,MLST8,UBA52,AKT2,CASP9,PLCG1,RBSN,CRK,PSMD13,RPS27A,LIMK1,CFD,MAP3K11,KITLG,PPP2R5C,GSK3B,ARRB2,GAB1,HMGB1,PSMB1,POLR2K,POLR3H,UBA3,VAV2,PIK3R4,DHX9,PSMD9,MYO1C,PRKCE,CD59,ARPC5,MAPK9,RNF135,MAPK7,CYFIP1,MYO10,MAPKAPK3,PSMC3,RAP1B,RASAL1,C1R,CAPZA2,MAP2K2,PSMA4,PSMB3,RASA1,XRCC5,DUSP3,ITPR1,PPP3R1,ARPC2,IFIH1,MAP2K4,RPS6KA3,IRF1,MAPK8,EP300,BTC,SPRED2,SPRED1,DNM3,RASAL2,IQGAP1,RAF1,PEBP1,RAC1,ACTR3,CHUK,BCL2L1,PRKACA,EEA1,SHC1,TRIM25,TXNIP,ADCY9,CASP2,PSMD14,CDKN1B,RICTOR,UBE2D1,CASP8,ATF2,RELA,GSK3A,POLR2L,HSP90AB1,CUL3,DLG4,ITPR3,FGFR1,IRS2,PPP2R5E,CAMK2D,FYN,DDOST,TICAM1,ATG5,PPP5C,UBE2N,PSMD5,OTUD5,TNRC6B,DUSP2,BRAF,TRAF2,HERC5,B2M,SIKE1,RPS6KA5,FOXO3,PSMF1,ABL1,PSMD2,THEM4,PTPN11,ERBB3,MAP3K14,UBB,MAP3K1,PSMB6,SPTAN1,PDPK1,TNFAIP3,MAP2K7,SOS1,PIK3R1,PTK2,YES1,PSMD4,UBC,TRIB3,NOD1,CDC34,WDR83,DHX36,FBXW11,WASF1,NF1,PTPRA,ITPR2,CDKN1A,BIRC2,MAP2K3,RPS6KA2,PSMB8,RAP1A,CTNNB1,NCKIPSD,PSMC2,IRAK4,PIK3R2,POLR3B,WIPF2,PRKACB,RBX1,NCK1,ITCH,KSR2,ATG12,UBE2V1,CRCP,PSMB2,ACTB,PSMC5,PSMC1,PPP2R5D,UBE2D3,PSMB5,LGALS3,PHB,PSMD7,LAMTOR3,CALM3,CAMK4,CNKSR1,MEF2A,PPP3CB,DUSP5,UBE2L6,PAK2,CAPZA1,PSMA5,POLR3F,ABI2,ECSIT,MALT1,ARPC1A,ISG15,BAIAP2,PSMC4,POLR2E,EREG,PLD1,AGO3,TIRAP,WASF2,AKAP9,MTOR,PSMA2,MAP2K1,ERBB2,IRF3,LYN,PSMA6,MDM2,SOCS1,BRK1,SPTBN1,IKBKB,PSME4,PIK3R3,NFKB2,C2,AHCYL1,VCL,AKT1,BIRC3,DDX41,PSMB7,DUSP4,CASP4,TAB2,PSMC6,DUSP16,STAT6,WASL,PSMD3,PSMD6,TAB1,MOV10,TNIP2,MAPK1,TAB3,TAX1BP1,MAPKAP1,PSMD10,ARPC4,PANX1,ATF1,TANK,TRIM21,JAK2,PSMD11,HSP90AA1,PLA2G6,DUSP1,RPS6KB2,TBK1,PSMB4,FOXO4,NR4A1,PRKDC,POLR3GL,TLR6,POLR3A,MAPK3,GRB2,SUGT1,MAP2K6,UBE2D2,KBTBD7,DTX4,PAQR3,POLR1C,NFKBIB,HRAS
R-HSA-389661	Glyoxylate metabolism and glycine degradation	0.736165879431187	-0.306299805985502	9	3	0.000953591862682772	3146	8202	9380,2653,2731	GRHPR,GCSH,GLDC
R-HSA-425986	Sodium/Proton exchangers	0.736165879431187	-0.306299805985502	9	3	0.000953591862682772	3146	8202	6548,23315,10479	SLC9A1,SLC9A8,SLC9A6
R-HSA-425381	Bicarbonate transporters	0.736165879431187	-0.306299805985502	9	3	0.000953591862682772	3146	8202	9497,6522,8671	SLC4A7,SLC4A2,SLC4A4
R-HSA-70635	Urea cycle	0.736165879431187	-0.306299805985502	9	3	0.000953591862682772	3146	8202	10166,1373,435	SLC25A15,CPS1,ASL
R-HSA-2179392	EGFR Transactivation by Gastrin	0.736165879431187	-0.306299805985502	9	3	0.000953591862682772	3146	8202	2885,6654,3265	GRB2,SOS1,HRAS
R-HSA-419408	Lysosphingolipid and LPA receptors	0.736165879431187	-0.306299805985502	9	3	0.000953591862682772	3146	8202	9170,53637,23566	LPAR2,S1PR5,LPAR3
R-HSA-447041	CHL1 interactions	0.736165879431187	-0.306299805985502	9	3	0.000953591862682772	3146	8202	8829,3673,3688	NRP1,ITGA2,ITGB1
R-HSA-201688	WNT mediated activation of DVL	0.736165879431187	-0.306299805985502	9	3	0.000953591862682772	3146	8202	1857,1454,1856	DVL3,CSNK1E,DVL2
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	0.737862185050251	-0.30399821294428	32	11	0.0034965034965035	3146	8202	2768,10681,2785,59345,2782,5594,10672,409,2783,2767,5595	GNA12,GNB5,GNG3,GNB4,GNB1,MAPK1,GNA13,ARRB2,GNB2,GNA11,MAPK3
R-HSA-2160916	Hyaluronan uptake and degradation	0.738193254545271	-0.303549626134204	12	4	0.00127145581691036	3146	8202	6548,3373,3073,11261	SLC9A1,HYAL1,HEXA,CHP1
R-HSA-451308	Activation of Ca-permeable Kainate Receptor	0.738193254545271	-0.303549626134204	12	4	0.00127145581691036	3146	8202	808,1742,1741,1739	CALM3,DLG4,DLG3,DLG1
R-HSA-451306	Ionotropic activity of Kainate Receptors	0.738193254545271	-0.303549626134204	12	4	0.00127145581691036	3146	8202	808,1742,1741,1739	CALM3,DLG4,DLG3,DLG1
R-HSA-844456	The NLRP3 inflammasome	0.738193254545271	-0.303549626134204	12	4	0.00127145581691036	3146	8202	10910,3326,10628,24145	SUGT1,HSP90AB1,TXNIP,PANX1
R-HSA-389359	CD28 dependent Vav1 pathway	0.738193254545271	-0.303549626134204	12	4	0.00127145581691036	3146	8202	2885,2534,5879,5062	GRB2,FYN,RAC1,PAK2
R-HSA-909733	Interferon alpha/beta signaling	0.739114005208	-0.302303100367985	68	24	0.00762873490146217	3146	8202	4599,1958,5777,11274,3430,3661,3454,7297,9636,6773,8519,3663,3105,9021,5696,8651,25939,684,5781,3660,103,4940,2537,3659	MX1,EGR1,PTPN6,USP18,IFI35,IRF3,IFNAR1,TYK2,ISG15,STAT2,IFITM1,IRF5,HLA-A,SOCS3,PSMB8,SOCS1,SAMHD1,BST2,PTPN11,IRF2,ADAR,OAS3,IFI6,IRF1
R-HSA-1482883	Acyl chain remodeling of DAG and TAG	0.740378779179266	-0.300593359985723	6	2	0.000635727908455181	3146	8202	8694,84649	DGAT1,DGAT2
R-HSA-6782861	Synthesis of wybutosine at G37 of tRNA(Phe)	0.740378779179266	-0.300593359985723	6	2	0.000635727908455181	3146	8202	127253,55253	TYW3,TYW1
R-HSA-1566977	Fibronectin matrix formation	0.740378779179266	-0.300593359985723	6	2	0.000635727908455181	3146	8202	3678,3688	ITGA5,ITGB1
R-HSA-975578	Reactions specific to the complex N-glycan synthesis pathway	0.740378779179266	-0.300593359985723	6	2	0.000635727908455181	3146	8202	4122,2517	MAN2A2,FUCA1
R-HSA-947581	Molybdenum cofactor biosynthesis	0.740378779179266	-0.300593359985723	6	2	0.000635727908455181	3146	8202	55034,9054	MOCOS,NFS1
R-HSA-5626978	TNFR1-mediated ceramide production	0.740378779179266	-0.300593359985723	6	2	0.000635727908455181	3146	8202	10399,8439	GNB2L1,NSMAF
R-HSA-2142712	Synthesis of 12-eicosatetraenoic acid derivatives	0.740378779179266	-0.300593359985723	6	2	0.000635727908455181	3146	8202	2876,2879	GPX1,GPX4
R-HSA-2142688	Synthesis of 5-eicosatetraenoic acids	0.740378779179266	-0.300593359985723	6	2	0.000635727908455181	3146	8202	2876,2879	GPX1,GPX4
R-HSA-77288	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	0.740378779179266	-0.300593359985723	6	2	0.000635727908455181	3146	8202	1632,3032	ECI1,HADHB
R-HSA-211916	Vitamins	0.740378779179266	-0.300593359985723	6	2	0.000635727908455181	3146	8202	1591,1592	CYP24A1,CYP26A1
R-HSA-1912399	Pre-NOTCH Processing in the Endoplasmic Reticulum	0.740378779179266	-0.300593359985723	6	2	0.000635727908455181	3146	8202	56983,23509	POGLUT1,POFUT1
R-HSA-5339717	Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	0.740378779179266	-0.300593359985723	6	2	0.000635727908455181	3146	8202	79412,22943	KREMEN2,DKK1
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	0.742666311154781	-0.297508445299622	15	5	0.00158931977113795	3146	8202	2885,5906,5747,6654,5908	GRB2,RAP1A,PTK2,SOS1,RAP1B
R-HSA-549132	Organic cation/anion/zwitterion transport	0.742666311154781	-0.297508445299622	15	5	0.00158931977113795	3146	8202	55356,861,6583,5002,6584	SLC22A15,RUNX1,SLC22A4,SLC22A18,SLC22A5
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	0.742666311154781	-0.297508445299622	15	5	0.00158931977113795	3146	8202	5906,5747,1398,9564,5908	RAP1A,PTK2,CRK,BCAR1,RAP1B
R-HSA-1912420	Pre-NOTCH Processing in Golgi	0.748204349695384	-0.290079143538633	18	6	0.00190718372536554	3146	8202	6484,5870,488,3955,6487,5045	ST3GAL4,RAB6A,ATP2A2,LFNG,ST3GAL3,FURIN
R-HSA-1630316	Glycosaminoglycan metabolism	0.752792280159754	-0.283965945599157	123	44	0.013986013986014	3146	8202	11046,50515,283464,57214,113189,2131,22856,347734,8702,6382,2132,9435,10675,6484,3038,55501,9061,6548,3373,1836,3425,55454,11261,10678,8509,6487,26035,3423,6448,221914,10855,51363,9469,92126,2720,9953,11041,3073,54480,6482,8704,11285,266722,9653	SLC35D2,CHST11,GXYLT1,CEMIP,CHST14,EXT1,CHSY1,SLC35B2,B4GALT4,SDC1,EXT2,CHST2,CSPG5,ST3GAL4,HAS3,CHST12,PAPSS1,SLC9A1,HYAL1,SLC26A2,IDUA,CSGALNACT2,CHP1,B3GNT2,NDST2,ST3GAL3,GLCE,IDS,SGSH,GPC2,HPSE,CHST15,CHST3,DSEL,GLB1,HS3ST3B1,B4GAT1,HEXA,CHPF2,ST3GAL1,B4GALT2,B4GALT7,HS6ST3,HS2ST1
R-HSA-2024096	HS-GAG degradation	0.754202053312778	-0.28209497165724	21	7	0.00222504767959313	3146	8202	3423,2720,6448,221914,10855,6382,3425	IDS,GLB1,SGSH,GPC2,HPSE,SDC1,IDUA
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	0.754202053312778	-0.28209497165724	21	7	0.00222504767959313	3146	8202	22948,7203,10576,7280,6950,10383,10381	CCT5,CCT3,CCT2,TUBB2A,TCP1,TUBB4B,TUBB3
R-HSA-5602680	MyD88 deficiency (TLR5)	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	51135	IRAK4
R-HSA-70350	Fructose catabolism	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	3795	KHK
R-HSA-5624958	ARL13B-mediated ciliary trafficking of INPP5E	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	5147	PDE6D
R-HSA-964827	Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	10905	MAN1A2
R-HSA-77108	Utilization of Ketone Bodies	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	38	ACAT1
R-HSA-191650	Regulation of gap junction activity	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	7082	TJP1
R-HSA-77285	Beta oxidation of myristoyl-CoA to lauroyl-CoA	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	3032	HADHB
R-HSA-191647	c-src mediated regulation of Cx43 function and closure of gap junctions	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	7082	TJP1
R-HSA-198745	Signalling to STAT3	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	6774	STAT3
R-HSA-844455	The NLRP1 inflammasome	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	598	BCL2L1
R-HSA-77305	Beta oxidation of palmitoyl-CoA to myristoyl-CoA	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	3032	HADHB
R-HSA-77352	Beta oxidation of butanoyl-CoA to acetyl-CoA	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	1892	ECHS1
R-HSA-350864	Regulation of thyroid hormone activity	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	1734	DIO2
R-HSA-392023	Adrenaline signalling through Alpha-2 adrenergic receptor	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	151	ADRA2B
R-HSA-351200	Interconversion of polyamines	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	6303	SAT1
R-HSA-180897	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	291	SLC25A4
R-HSA-190374	FGFR1c and Klotho ligand binding and activation	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	2260	FGFR1
R-HSA-5250958	Toxicity of botulinum toxin type B (BoNT/B)	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	6857	SYT1
R-HSA-5688031	Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	7270	TTF1
R-HSA-5602571	TRAF3 deficiency - HSE	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	148022	TICAM1
R-HSA-139910	Activation of BMF and translocation to mitochondria	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	5599	MAPK8
R-HSA-5250992	Toxicity of botulinum toxin type E (BoNT/E)	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	6616	SNAP25
R-HSA-5635851	GLI proteins bind promoters of Hh responsive genes to promote transcription	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	2737	GLI3
R-HSA-5250989	Toxicity of botulinum toxin type G (BoNT/G)	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	6857	SYT1
R-HSA-880009	Interconversion of 2-oxoglutarate and 2-hydroxyglutarate	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	728294	D2HGDH
R-HSA-5250971	Toxicity of botulinum toxin type C (BoNT/C)	0.765812864989636	-0.266817440668147	3	1	0.000317863954227591	3146	8202	6616	SNAP25
R-HSA-1638074	Keratan sulfate/keratin metabolism	0.778592178886121	-0.250267888954974	33	11	0.0034965034965035	3146	8202	6484,11046,10678,2720,11041,8702,3073,6482,6487,9435,8704	ST3GAL4,SLC35D2,B3GNT2,GLB1,B4GAT1,B4GALT4,HEXA,ST3GAL1,ST3GAL3,CHST2,B4GALT2
R-HSA-163841	Gamma carboxylation, hypusine formation and arylsulfatase activation	0.784411851507492	-0.242821075764025	36	12	0.00381436745073109	3146	8202	83475,1984,2677,1938,1801,1725,1802,56648,5045,120526,25870,285362	DOHH,EIF5A,GGCX,EEF2,DPH1,DHPS,DPH2,EIF5A2,FURIN,DNAJC24,SUMF2,SUMF1
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.798044274853672	-0.225591200798641	16	5	0.00158931977113795	3146	8202	23523,3008,3159,25842,3009	CABIN1,HIST1H1E,HMGA1,ASF1A,HIST1H1B
R-HSA-399956	CRMPs in Sema3A signaling	0.798044274853672	-0.225591200798641	16	5	0.00158931977113795	3146	8202	2932,2534,8829,1808,2242	GSK3B,FYN,NRP1,DPYSL2,FES
R-HSA-5218859	Regulated Necrosis	0.798044274853672	-0.225591200798641	16	5	0.00158931977113795	3146	8202	8743,841,330,7186,329	TNFSF10,CASP8,BIRC3,TRAF2,BIRC2
R-HSA-416993	Trafficking of GluR2-containing AMPA receptors	0.798044274853672	-0.225591200798641	16	5	0.00158931977113795	3146	8202	163,1173,1175,160,9463	AP2B1,AP2M1,AP2S1,AP2A1,PICK1
R-HSA-5213460	RIPK1-mediated regulated necrosis	0.798044274853672	-0.225591200798641	16	5	0.00158931977113795	3146	8202	8743,841,330,7186,329	TNFSF10,CASP8,BIRC3,TRAF2,BIRC2
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor	0.798872135838317	-0.224554376261971	19	6	0.00190718372536554	3146	8202	2778,2782,10681,2785,2783,59345	GNAS,GNB1,GNB5,GNG3,GNB2,GNB4
R-HSA-1181150	Signaling by NODAL	0.798872135838317	-0.224554376261971	19	6	0.00190718372536554	3146	8202	4088,92,4087,2309,4089,5045	SMAD3,ACVR2A,SMAD2,FOXO3,SMAD4,FURIN
R-HSA-3928664	Ephrin signaling	0.798872135838317	-0.224554376261971	19	6	0.00190718372536554	3146	8202	2534,2050,1947,5062,5879,2049	FYN,EPHB4,EFNB1,PAK2,RAC1,EPHB3
R-HSA-428790	Facilitative Na+-independent glucose transporters	0.799424596221337	-0.223863064825314	13	4	0.00127145581691036	3146	8202	154091,6517,29988,11182	SLC2A12,SLC2A4,SLC2A8,SLC2A6
R-HSA-5655332	Signaling by FGFR3 in disease	0.800976355109654	-0.221923851563393	22	7	0.00222504767959313	3146	8202	2885,5335,6654,3265,10818,2549,5295	GRB2,PLCG1,SOS1,HRAS,FRS2,GAB1,PIK3R1
R-HSA-1482788	Acyl chain remodelling of PC	0.803848042752774	-0.218345029217491	25	8	0.00254291163382072	3146	8202	81579,10162,50640,11145,129642,79888,8398,254531	PLA2G12A,LPCAT3,PNPLA8,PLA2G16,MBOAT2,LPCAT1,PLA2G6,LPCAT4
R-HSA-425410	Metal ion SLC transporters	0.803848042752774	-0.218345029217491	25	8	0.00254291163382072	3146	8202	1317,254428,64116,55676,4891,7779,27173,148867	SLC31A1,SLC41A1,SLC39A8,SLC30A6,SLC11A2,SLC30A1,SLC39A1,SLC30A7
R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	0.804903622576569	-0.217032732238373	10	3	0.000953591862682772	3146	8202	4361,3980,10721	MRE11A,LIG3,POLQ
R-HSA-418886	Netrin mediated repulsion signals	0.804903622576569	-0.217032732238373	10	3	0.000953591862682772	3146	8202	2534,5747,5781	FYN,PTK2,PTPN11
R-HSA-2022854	Keratan sulfate biosynthesis	0.807188618905882	-0.214197909514532	28	9	0.00286077558804832	3146	8202	6484,11046,10678,11041,8702,6482,6487,8704,9435	ST3GAL4,SLC35D2,B3GNT2,B4GAT1,B4GALT4,ST3GAL1,ST3GAL3,B4GALT2,CHST2
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion	0.807188618905882	-0.214197909514532	28	9	0.00286077558804832	3146	8202	10681,2785,783,59345,2782,784,2771,2783,2770	GNB5,GNG3,CACNB2,GNB4,GNB1,CACNB3,GNAI2,GNB2,GNAI1
R-HSA-202040	G-protein activation	0.807188618905882	-0.214197909514532	28	9	0.00286077558804832	3146	8202	10681,2781,2785,59345,2782,2771,2773,2783,2770	GNB5,GNAZ,GNG3,GNB4,GNB1,GNAI2,GNAI3,GNB2,GNAI1
R-HSA-2022928	HS-GAG biosynthesis	0.810813487387097	-0.209717229876764	31	10	0.00317863954227591	3146	8202	11046,221914,8509,9953,2131,6382,2132,26035,266722,9653	SLC35D2,GPC2,NDST2,HS3ST3B1,EXT1,SDC1,EXT2,GLCE,HS6ST3,HS2ST1
R-HSA-1489509	DAG and IP3 signaling	0.814603973410745	-0.205053206035129	34	11	0.0034965034965035	3146	8202	5581,5335,3708,115,814,808,3709,10768,3710,5566,5567	PRKCE,PLCG1,ITPR1,ADCY9,CAMK4,CALM3,ITPR2,AHCYL1,ITPR3,PRKACA,PRKACB
R-HSA-5654727	Negative regulation of FGFR2 signaling	0.814603973410745	-0.205053206035129	34	11	0.0034965034965035	3146	8202	2885,7311,673,6233,5781,7314,5594,10253,10818,7316,5595	GRB2,UBA52,BRAF,RPS27A,PTPN11,UBB,MAPK1,SPRY2,FRS2,UBC,MAPK3
R-HSA-1638091	Heparan sulfate/heparin (HS-GAG) metabolism	0.815875736879256	-0.203493218850506	54	18	0.00572155117609663	3146	8202	11046,283464,8509,2131,6382,2132,10675,26035,3423,6448,10855,221914,2720,9953,3425,11285,266722,9653	SLC35D2,GXYLT1,NDST2,EXT1,SDC1,EXT2,CSPG5,GLCE,IDS,SGSH,HPSE,GPC2,GLB1,HS3ST3B1,IDUA,B4GALT7,HS6ST3,HS2ST1
R-HSA-76009	Platelet Aggregation (Plug Formation)	0.818481506675457	-0.200304476591799	37	12	0.00381436745073109	3146	8202	2885,5170,5906,6464,1398,207,6654,5908,2812,5747,151,9564	GRB2,PDPK1,RAP1A,SHC1,CRK,AKT1,SOS1,RAP1B,GP1BB,PTK2,ADRA2B,BCAR1
R-HSA-1251932	PLCG1 events in ERBB2 signaling	0.818481506675457	-0.200304476591799	37	12	0.00381436745073109	3146	8202	5581,5335,115,3708,808,2064,814,3709,3710,10768,5566,5567	PRKCE,PLCG1,ADCY9,ITPR1,CALM3,ERBB2,CAMK4,ITPR2,ITPR3,AHCYL1,PRKACA,PRKACB
R-HSA-442720	CREB phosphorylation through the activation of Adenylate Cyclase	0.818971189282584	-0.199706373668968	7	2	0.000635727908455181	3146	8202	5566,5567	PRKACA,PRKACB
R-HSA-83936	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	0.818971189282584	-0.199706373668968	7	2	0.000635727908455181	3146	8202	2030,3177	SLC29A1,SLC29A2
R-HSA-75158	TRAIL  signaling	0.818971189282584	-0.199706373668968	7	2	0.000635727908455181	3146	8202	8743,841	TNFSF10,CASP8
R-HSA-110362	POLB-Dependent Long Patch Base Excision Repair	0.818971189282584	-0.199706373668968	7	2	0.000635727908455181	3146	8202	3978,328	LIG1,APEX1
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.818971189282584	-0.199706373668968	7	2	0.000635727908455181	3146	8202	3280,3516	HES1,RBPJ
R-HSA-420597	Nectin/Necl  trans heterodimerization	0.818971189282584	-0.199706373668968	7	2	0.000635727908455181	3146	8202	5817,25945	PVR,PVRL3
R-HSA-2187335	The retinoid cycle in cones (daylight vision)	0.818971189282584	-0.199706373668968	7	2	0.000635727908455181	3146	8202	9249,611	DHRS3,OPN1SW
R-HSA-426496	Post-transcriptional silencing by small RNAs	0.818971189282584	-0.199706373668968	7	2	0.000635727908455181	3146	8202	23112,192669	TNRC6B,AGO3
R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.818971189282584	-0.199706373668968	7	2	0.000635727908455181	3146	8202	1499,6934	CTNNB1,TCF7L2
R-HSA-418597	G alpha (z) signalling events	0.830182434959822	-0.186109801187816	46	15	0.00476795931341386	3146	8202	2778,5581,10681,2781,2785,59345,10287,115,8601,2782,2771,2773,151,2783,2770	GNAS,PRKCE,GNB5,GNAZ,GNG3,GNB4,RGS19,ADCY9,RGS20,GNB1,GNAI2,GNAI3,ADRA2B,GNB2,GNAI1
R-HSA-428930	Thromboxane signalling through TP receptor	0.840610857100032	-0.173626440601083	23	7	0.00222504767959313	3146	8202	2782,10681,10672,2785,2783,59345,2767	GNB1,GNB5,GNA13,GNG3,GNB2,GNB4,GNA11
R-HSA-211976	Endogenous sterols	0.840610857100032	-0.173626440601083	23	7	0.00222504767959313	3146	8202	112812,10858,51302,2232,2230,6256,1545	FDX1L,CYP46A1,CYP39A1,FDXR,FDX1,RXRA,CYP1B1
R-HSA-912694	Regulation of IFNA signaling	0.841066462011441	-0.173084594769688	26	8	0.00254291163382072	3146	8202	8651,5777,11274,5781,3454,7297,6773,9021	SOCS1,PTPN6,USP18,PTPN11,IFNAR1,TYK2,STAT2,SOCS3
R-HSA-3238698	WNT ligand biogenesis and trafficking	0.841066462011441	-0.173084594769688	26	8	0.00254291163382072	3146	8202	7481,50999,7480,64840,9559,51699,8724,7474	WNT11,TMED5,WNT10B,PORCN,VPS26A,VPS29,SNX3,WNT5A
R-HSA-622312	Inflammasomes	0.843549906741378	-0.170136212485102	17	5	0.00158931977113795	3146	8202	10910,598,3326,10628,24145	SUGT1,BCL2L1,HSP90AB1,TXNIP,PANX1
R-HSA-435354	Zinc transporters	0.843549906741378	-0.170136212485102	17	5	0.00158931977113795	3146	8202	7779,64116,27173,55676,148867	SLC30A1,SLC39A8,SLC39A1,SLC30A6,SLC30A7
R-HSA-1482801	Acyl chain remodelling of PS	0.843549906741378	-0.170136212485102	17	5	0.00158931977113795	3146	8202	81579,10162,154141,11145,254531	PLA2G12A,LPCAT3,MBOAT1,PLA2G16,LPCAT4
R-HSA-392518	Signal amplification	0.843973170270817	-0.169634573670107	32	10	0.00317863954227591	3146	8202	10681,2785,59345,2782,2771,10672,2773,2783,2767,2770	GNB5,GNG3,GNB4,GNB1,GNAI2,GNA13,GNAI3,GNB2,GNA11,GNAI1
R-HSA-170670	Adenylate cyclase inhibitory pathway	0.848483694494514	-0.164304411352238	14	4	0.00127145581691036	3146	8202	2771,2773,115,2770	GNAI2,GNAI3,ADCY9,GNAI1
R-HSA-997269	Inhibition of adenylate cyclase pathway	0.848483694494514	-0.164304411352238	14	4	0.00127145581691036	3146	8202	2771,2773,115,2770	GNAI2,GNAI3,ADCY9,GNAI1
R-HSA-446343	Localization of the PINCH-ILK-PARVIN complex to focal adhesions	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	3688	ITGB1
R-HSA-5250968	Toxicity of botulinum toxin type A (BoNT/A)	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	6616	SNAP25
R-HSA-5221030	TET1,2,3 and TDG demethylate DNA	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	6996	TDG
R-HSA-193144	Estrogen biosynthesis	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	51170	HSD17B11
R-HSA-173736	Alternative complement activation	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	1675	CFD
R-HSA-75072	mRNA Editing	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	103	ADAR
R-HSA-1296053	Classical Kir channels	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	3759	KCNJ2
R-HSA-69200	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	898	CCNE1
R-HSA-2473224	Antagonism of Activin by Follistatin	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	10272	FSTL3
R-HSA-5603037	IRAK4 deficiency (TLR5)	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	51135	IRAK4
R-HSA-427975	Proton/oligopeptide cotransporters	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	121260	SLC15A4
R-HSA-1369007	Mitochondrial ABC transporters	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	23456	ABCB10
R-HSA-75944	Transcription from mitochondrial promoters	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	7978	MTERF1
R-HSA-139915	Activation of PUMA and translocation to mitochondria	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	7027	TFDP1
R-HSA-1296025	ATP sensitive Potassium channels	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	3767	KCNJ11
R-HSA-390650	Histamine receptors	0.855671716899184	-0.155868484693854	4	1	0.000317863954227591	3146	8202	3269	HRH1
R-HSA-2022923	Dermatan sulfate biosynthesis	0.857860297556808	-0.1533140161117	11	3	0.000953591862682772	3146	8202	113189,92126,10675	CHST14,DSEL,CSPG5
R-HSA-71182	Phenylalanine and tyrosine catabolism	0.857860297556808	-0.1533140161117	11	3	0.000953591862682772	3146	8202	2954,883,80150	GSTZ1,CCBL1,ASRGL1
R-HSA-3371378	Regulation by c-FLIP	0.857860297556808	-0.1533140161117	11	3	0.000953591862682772	3146	8202	8743,841,7186	TNFSF10,CASP8,TRAF2
R-HSA-5602498	MyD88 deficiency (TLR2/4)	0.857860297556808	-0.1533140161117	11	3	0.000953591862682772	3146	8202	10333,51135,114609	TLR6,IRAK4,TIRAP
R-HSA-5218900	CASP8 activity is inhibited	0.857860297556808	-0.1533140161117	11	3	0.000953591862682772	3146	8202	8743,841,7186	TNFSF10,CASP8,TRAF2
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	0.857860297556808	-0.1533140161117	11	3	0.000953591862682772	3146	8202	10333,51135,114609	TLR6,IRAK4,TIRAP
R-HSA-3296469	Defects in cobalamin (B12) metabolism	0.857860297556808	-0.1533140161117	11	3	0.000953591862682772	3146	8202	25974,166785,4552	MMACHC,MMAA,MTRR
R-HSA-69416	Dimerization of procaspase-8	0.857860297556808	-0.1533140161117	11	3	0.000953591862682772	3146	8202	8743,841,7186	TNFSF10,CASP8,TRAF2
R-HSA-428157	Sphingolipid metabolism	0.865341808626717	-0.144630695621476	76	25	0.00794659885568976	3146	8202	57704,7357,10825,91012,8612,10087,2629,55331,8877,427,285362,25870,9517,2531,8611,221,253782,8560,9217,2720,5007,2717,3073,56848,224	GBA2,UGCG,NEU3,CERS5,PLPP2,COL4A3BP,GBA,ACER3,SPHK1,ASAH1,SUMF1,SUMF2,SPTLC2,KDSR,PLPP1,ALDH3B1,CERS6,DEGS1,VAPB,GLB1,OSBP,GLA,HEXA,SPHK2,ALDH3A2
R-HSA-157858	Gap junction trafficking and regulation	0.872109475074191	-0.136840318143395	30	9	0.00286077558804832	3146	8202	1173,8218,375519,1213,1785,7082,2707,4646,10052	AP2M1,CLTCL1,GJB7,CLTC,DNM2,TJP1,GJB3,MYO6,GJC1
R-HSA-4085001	Sialic acid metabolism	0.872399688261701	-0.136507601988861	33	10	0.00317863954227591	3146	8202	6484,10825,6480,10020,2720,256435,26503,10610,6482,6487	ST3GAL4,NEU3,ST6GAL1,GNE,GLB1,ST6GALNAC3,SLC17A5,ST6GALNAC2,ST3GAL1,ST3GAL3
R-HSA-5357769	Caspase activation via extrinsic apoptotic signalig pathway	0.872449497731767	-0.136450508836652	27	8	0.00254291163382072	3146	8202	836,7186,842,8743,148022,841,26060,1613	CASP3,TRAF2,CASP9,TNFSF10,TICAM1,CASP8,APPL1,DAPK3
R-HSA-114508	Effects of PIP2 hydrolysis	0.872449497731767	-0.136450508836652	27	8	0.00254291163382072	3146	8202	5581,8527,3709,221955,3710,26090,57406,3708	PRKCE,DGKD,ITPR2,DAGLB,ITPR3,ABHD12,ABHD6,ITPR1
R-HSA-167021	PLC-gamma1 signalling	0.8731559676116	-0.135641082041845	36	11	0.0034965034965035	3146	8202	5581,5335,115,3708,808,814,3709,3710,10768,5566,5567	PRKCE,PLCG1,ADCY9,ITPR1,CALM3,CAMK4,ITPR2,ITPR3,AHCYL1,PRKACA,PRKACB
R-HSA-212718	EGFR interacts with phospholipase C-gamma	0.8731559676116	-0.135641082041845	36	11	0.0034965034965035	3146	8202	5581,5335,115,3708,808,814,3709,3710,10768,5566,5567	PRKCE,PLCG1,ADCY9,ITPR1,CALM3,CAMK4,ITPR2,ITPR3,AHCYL1,PRKACA,PRKACB
R-HSA-6788656	Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism	0.874260295825337	-0.13437712635611	39	12	0.00381436745073109	3146	8202	8659,2954,5625,883,51166,80150,8942,56267,85007,2639,1743,125061	ALDH4A1,GSTZ1,PRODH,CCBL1,AADAT,ASRGL1,KYNU,CCBL2,PHYKPL,GCDH,DLST,AFMID
R-HSA-428643	Organic anion transporters	0.875485158028725	-0.132977079965632	8	2	0.000635727908455181	3146	8202	26503,1468	SLC17A5,SLC25A10
R-HSA-195399	VEGF binds to VEGFR leading to receptor dimerization	0.875485158028725	-0.132977079965632	8	2	0.000635727908455181	3146	8202	7422,7423	VEGFA,VEGFB
R-HSA-5362798	Release of Hh-Np from the secreting cell	0.875485158028725	-0.132977079965632	8	2	0.000635727908455181	3146	8202	6868,85455	ADAM17,DISP2
R-HSA-194313	VEGF ligand-receptor interactions	0.875485158028725	-0.132977079965632	8	2	0.000635727908455181	3146	8202	7422,7423	VEGFA,VEGFB
R-HSA-5632681	Ligand-receptor interactions	0.875485158028725	-0.132977079965632	8	2	0.000635727908455181	3146	8202	5727,2619	PTCH1,GAS1
R-HSA-77286	mitochondrial fatty acid beta-oxidation of saturated fatty acids	0.875485158028725	-0.132977079965632	8	2	0.000635727908455181	3146	8202	1892,3032	ECHS1,HADHB
R-HSA-192456	Digestion of dietary lipid	0.875485158028725	-0.132977079965632	8	2	0.000635727908455181	3146	8202	64788,91289	LMF1,LMF2
R-HSA-1483148	Synthesis of PG	0.875485158028725	-0.132977079965632	8	2	0.000635727908455181	3146	8202	8760,5337	CDS2,PLD1
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	0.875625994127482	-0.13281622655677	42	13	0.00413223140495868	3146	8202	2778,5906,10681,2785,8826,59345,3708,2782,3709,3710,5566,2783,5567	GNAS,RAP1A,GNB5,GNG3,IQGAP1,GNB4,ITPR1,GNB1,ITPR2,ITPR3,PRKACA,GNB2,PRKACB
R-HSA-392451	G beta:gamma signalling through PI3Kgamma	0.878897842475411	-0.12908660821554	48	15	0.00476795931341386	3146	8202	2885,5170,387,6464,10681,207,2785,208,59345,5296,5295,2782,8503,3717,2783	GRB2,PDPK1,RHOA,SHC1,GNB5,AKT1,GNG3,AKT2,GNB4,PIK3R2,PIK3R1,GNB1,PIK3R3,JAK2,GNB2
R-HSA-5223345	Miscellaneous transport and binding events	0.880221274820115	-0.127581954458579	18	5	0.00158931977113795	3146	8202	57185,152519,120,118,123606	NIPAL3,NIPAL1,ADD3,ADD1,NIPA1
R-HSA-975577	N-Glycan antennae elongation	0.886962742986738	-0.119952300951864	15	4	0.00127145581691036	3146	8202	6484,8702,6480,8704	ST3GAL4,B4GALT4,ST6GAL1,B4GALT2
R-HSA-3772470	Negative regulation of TCF-dependent signaling by WNT ligand antagonists	0.886962742986738	-0.119952300951864	15	4	0.00127145581691036	3146	8202	4040,79412,7474,22943	LRP6,KREMEN2,WNT5A,DKK1
R-HSA-1500931	Cell-Cell communication	0.889901479968101	-0.116644519048334	131	44	0.013986013986014	3146	8202	9076,5599,3728,5817,1495,8826,5879,50848,64398,84612,667,7408,1499,23607,25945,6711,5296,5781,5584,1366,6709,8573,3987,8935,137075,4690,5777,5295,10979,87,5339,5747,6251,10207,2885,29780,64403,2534,8976,961,3688,2185,81,1500	CLDN1,MAPK8,JUP,PVR,CTNNA1,IQGAP1,RAC1,F11R,MPP5,PARD6B,DST,VASP,CTNNB1,CD2AP,PVRL3,SPTBN1,PIK3R2,PTPN11,PRKCI,CLDN7,SPTAN1,CASK,LIMS1,SKAP2,CLDN23,NCK1,PTPN6,PIK3R1,FERMT2,ACTN1,PLEC,PTK2,RSU1,INADL,GRB2,PARVB,CDH24,FYN,WASL,CD47,ITGB1,PTK2B,ACTN4,CTNND1
R-HSA-156581	Methylation	0.897749311915283	-0.10786441233095	12	3	0.000953591862682772	3146	8202	7172,4144,4552	TPMT,MAT2A,MTRR
R-HSA-112043	PLC beta mediated events	0.89775328831482	-0.107859983042419	46	14	0.00445009535918627	3146	8202	2781,115,3708,808,814,3709,3710,10768,2771,2773,5566,5594,5567,2770	GNAZ,ADCY9,ITPR1,CALM3,CAMK4,ITPR2,ITPR3,AHCYL1,GNAI2,GNAI3,PRKACA,MAPK1,PRKACB,GNAI1
R-HSA-190828	Gap junction trafficking	0.898553849276713	-0.106968642137356	28	8	0.00254291163382072	3146	8202	1173,8218,375519,1213,1785,2707,4646,10052	AP2M1,CLTCL1,GJB7,CLTC,DNM2,GJB3,MYO6,GJC1
R-HSA-111885	Opioid Signalling	0.902662309980493	-0.102406760091516	84	27	0.00858232676414495	3146	8202	5141,2785,814,2782,808,5532,3709,3710,2773,5566,2783,5519,2770,10681,2781,59345,115,3708,5534,5533,5144,5499,10768,2771,5594,5528,5567	PDE4A,GNG3,CAMK4,GNB1,CALM3,PPP3CB,ITPR2,ITPR3,GNAI3,PRKACA,GNB2,PPP2R1B,GNAI1,GNB5,GNAZ,GNB4,ADCY9,ITPR1,PPP3R1,PPP3CC,PDE4D,PPP1CA,AHCYL1,GNAI2,MAPK1,PPP2R5D,PRKACB
R-HSA-975576	N-glycan antennae elongation in the medial/trans-Golgi	0.90422801951871	-0.100673716414728	22	6	0.00190718372536554	3146	8202	4122,2517,6484,8702,6480,8704	MAN2A2,FUCA1,ST3GAL4,B4GALT4,ST6GAL1,B4GALT2
R-HSA-163685	Integration of energy metabolism	0.905827530195596	-0.0989063550832094	107	35	0.0111252383979657	3146	8202	2785,5565,8826,23568,10554,2782,3709,5566,2783,5519,5906,6945,10681,783,115,51085,4082,10768,6888,2771,31,5567,2194,6616,3710,2767,2770,2778,51422,291,59345,3708,784,3767,5528	GNG3,PRKAB2,IQGAP1,ARL2BP,AGPAT1,GNB1,ITPR2,PRKACA,GNB2,PPP2R1B,RAP1A,MLX,GNB5,CACNB2,ADCY9,MLXIPL,MARCKS,AHCYL1,TALDO1,GNAI2,ACACA,PRKACB,FASN,SNAP25,ITPR3,GNA11,GNAI1,GNAS,PRKAG2,SLC25A4,GNB4,ITPR1,CACNB3,KCNJ11,PPP2R5D
R-HSA-389977	Post-chaperonin tubulin folding pathway	0.909274538736736	-0.0951082075916754	19	5	0.00158931977113795	3146	8202	7280,1155,10383,6904,10381	TUBB2A,TBCB,TUBB4B,TBCD,TUBB3
R-HSA-442982	Ras activation uopn Ca2+ infux through NMDA receptor	0.909274538736736	-0.0951082075916754	19	5	0.00158931977113795	3146	8202	808,1742,817,10142,3265	CALM3,DLG4,CAMK2D,AKAP9,HRAS
R-HSA-140834	Extrinsic Pathway of Fibrin Clot Formation	0.91105800363792	-0.0931487134549511	5	1	0.000317863954227591	3146	8202	2152	F3
R-HSA-75157	FasL/ CD95L signaling	0.91105800363792	-0.0931487134549511	5	1	0.000317863954227591	3146	8202	841	CASP8
R-HSA-2161517	Abacavir transmembrane transport	0.91105800363792	-0.0931487134549511	5	1	0.000317863954227591	3146	8202	9429	ABCG2
R-HSA-427652	Sodium-coupled phosphate cotransporters	0.91105800363792	-0.0931487134549511	5	1	0.000317863954227591	3146	8202	6575	SLC20A2
R-HSA-114516	Disinhibition of SNARE formation	0.91105800363792	-0.0931487134549511	5	1	0.000317863954227591	3146	8202	6810	STX4
R-HSA-380095	Tachykinin receptors bind tachykinins	0.91105800363792	-0.0931487134549511	5	1	0.000317863954227591	3146	8202	6869	TACR1
R-HSA-196843	Vitamin B2 (riboflavin) metabolism	0.91105800363792	-0.0931487134549511	5	1	0.000317863954227591	3146	8202	80308	FLAD1
R-HSA-5624138	Trafficking of myristoylated proteins to the cilium	0.91105800363792	-0.0931487134549511	5	1	0.000317863954227591	3146	8202	403	ARL3
R-HSA-1169092	Activation of RAS in B cells	0.91105800363792	-0.0931487134549511	5	1	0.000317863954227591	3146	8202	3265	HRAS
R-HSA-202733	Cell surface interactions at the vascular wall	0.912082145979768	-0.0920252206178391	99	32	0.0101716465352829	3146	8202	6520,6654,5777,5295,9123,682,3678,50848,857,7525,481,10461,4067,9057,5478,2885,5335,90952,2534,6464,23657,23759,5296,961,2886,3688,2734,5781,6566,482,3685,3265	SLC3A2,SOS1,PTPN6,PIK3R1,SLC16A3,BSG,ITGA5,F11R,CAV1,YES1,ATP1B1,MERTK,LYN,SLC7A6,PPIA,GRB2,PLCG1,ESAM,FYN,SHC1,SLC7A11,PPIL2,PIK3R2,CD47,GRB7,ITGB1,GLG1,PTPN11,SLC16A1,ATP1B2,ITGAV,HRAS
R-HSA-2142816	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	0.915290666197844	-0.0885135961766183	9	2	0.000635727908455181	3146	8202	113612,1545	CYP2U1,CYP1B1
R-HSA-390696	Adrenoceptors	0.915290666197844	-0.0885135961766183	9	2	0.000635727908455181	3146	8202	154,151	ADRB2,ADRA2B
R-HSA-446107	Type I hemidesmosome assembly	0.915290666197844	-0.0885135961766183	9	2	0.000635727908455181	3146	8202	667,5339	DST,PLEC
R-HSA-112040	G-protein mediated events	0.915411467241618	-0.0883816238128543	47	14	0.00445009535918627	3146	8202	2781,115,3708,808,814,3709,3710,10768,2771,2773,5566,5594,5567,2770	GNAZ,ADCY9,ITPR1,CALM3,CAMK4,ITPR2,ITPR3,AHCYL1,GNAI2,GNAI3,PRKACA,MAPK1,PRKACB,GNAI1
R-HSA-1369062	ABC transporters in lipid homeostasis	0.916602232361007	-0.0870816714300369	16	4	0.00127145581691036	3146	8202	5824,215,8504,10347	PEX19,ABCD1,PEX3,ABCA7
R-HSA-451326	Activation of Kainate Receptors upon glutamate binding	0.918007168358176	-0.0855500797230976	32	9	0.00286077558804832	3146	8202	10681,2785,59345,1739,2782,1742,808,1741,2783	GNB5,GNG3,GNB4,DLG1,GNB1,DLG4,CALM3,DLG3,GNB2
R-HSA-5654719	SHC-mediated cascade:FGFR4	0.926681135673327	-0.0761457470514969	23	6	0.00190718372536554	3146	8202	2885,6464,6654,10818,3265,5781	GRB2,SHC1,SOS1,FRS2,HRAS,PTPN11
R-HSA-3000157	Laminin interactions	0.926681135673327	-0.0761457470514969	23	6	0.00190718372536554	3146	8202	3913,3685,3915,3673,3688,22795	LAMB2,ITGAV,LAMC1,ITGA2,ITGB1,NID2
R-HSA-212676	Dopamine Neurotransmitter Release Cycle	0.926681135673327	-0.0761457470514969	23	6	0.00190718372536554	3146	8202	8497,8573,6616,8500,6857,55327	PPFIA4,CASK,SNAP25,PPFIA1,SYT1,LIN7C
R-HSA-2029481	FCGR activation	0.927246726625886	-0.0755355928145306	13	3	0.000953591862682772	3146	8202	2534,7525,4067	FYN,YES1,LYN
R-HSA-397795	G-protein beta:gamma signalling	0.930379385717135	-0.0721628343890723	51	15	0.00476795931341386	3146	8202	2885,5170,387,6464,10681,207,2785,208,59345,5296,5295,2782,8503,3717,2783	GRB2,PDPK1,RHOA,SHC1,GNB5,AKT1,GNG3,AKT2,GNB4,PIK3R2,PIK3R1,GNB1,PIK3R3,JAK2,GNB2
R-HSA-418217	G beta:gamma signalling through PLC beta	0.931949552606492	-0.0704765938661471	20	5	0.00158931977113795	3146	8202	2782,10681,2785,2783,59345	GNB1,GNB5,GNG3,GNB2,GNB4
R-HSA-420029	Tight junction interactions	0.937411597185029	-0.0646328219197189	30	8	0.00254291163382072	3146	8202	9076,137075,5584,50848,64398,84612,1366,10207	CLDN1,CLDN23,PRKCI,F11R,MPP5,PARD6B,CLDN7,INADL
R-HSA-442729	CREB phosphorylation through the activation of CaMKII	0.939079871039177	-0.0628547437116086	17	4	0.00127145581691036	3146	8202	808,1742,817,10142	CALM3,DLG4,CAMK2D,AKAP9
R-HSA-140534	Ligand-dependent caspase activation	0.939079871039177	-0.0628547437116086	17	4	0.00127145581691036	3146	8202	8743,148022,841,7186	TNFSF10,TICAM1,CASP8,TRAF2
R-HSA-164378	PKA activation in glucagon signalling	0.939079871039177	-0.0628547437116086	17	4	0.00127145581691036	3146	8202	2778,5566,115,5567	GNAS,PRKACA,ADCY9,PRKACB
R-HSA-264642	Acetylcholine Neurotransmitter Release Cycle	0.939079871039177	-0.0628547437116086	17	4	0.00127145581691036	3146	8202	8497,6616,8500,6857	PPFIA4,SNAP25,PPFIA1,SYT1
R-HSA-192105	Synthesis of bile acids and bile salts	0.940433911173006	-0.0614139025952569	27	7	0.00222504767959313	3146	8202	6342,3295,11001,10858,51302,6256,10005	SCP2,HSD17B4,SLC27A2,CYP46A1,CYP39A1,RXRA,ACOT8
R-HSA-5655253	Signaling by FGFR2 in disease	0.940433911173006	-0.0614139025952569	27	7	0.00222504767959313	3146	8202	2885,5335,6654,3265,10818,2549,5295	GRB2,PLCG1,SOS1,HRAS,FRS2,GAB1,PIK3R1
R-HSA-168799	Neurotoxicity of clostridium toxins	0.942887427101958	-0.0588083808851662	10	2	0.000635727908455181	3146	8202	6616,6857	SNAP25,SYT1
R-HSA-419771	Opsins	0.942887427101958	-0.0588083808851662	10	2	0.000635727908455181	3146	8202	611,23596	OPN1SW,OPN3
R-HSA-418359	Reduction of cytosolic Ca++ levels	0.942887427101958	-0.0588083808851662	10	2	0.000635727908455181	3146	8202	488,493	ATP2A2,ATP2B4
R-HSA-2474795	Diseases associated with visual transduction	0.942887427101958	-0.0588083808851662	10	2	0.000635727908455181	3146	8202	222236,611	NAPEPLD,OPN1SW
R-HSA-442380	Zinc influx into cells by the SLC39 gene family	0.942887427101958	-0.0588083808851662	10	2	0.000635727908455181	3146	8202	64116,27173	SLC39A8,SLC39A1
R-HSA-399997	Acetylcholine regulates insulin secretion	0.942887427101958	-0.0588083808851662	10	2	0.000635727908455181	3146	8202	4082,2767	MARCKS,GNA11
R-HSA-2453864	Retinoid cycle disease events	0.942887427101958	-0.0588083808851662	10	2	0.000635727908455181	3146	8202	222236,611	NAPEPLD,OPN1SW
R-HSA-2562578	TRIF-mediated programmed cell death	0.942887427101958	-0.0588083808851662	10	2	0.000635727908455181	3146	8202	148022,841	TICAM1,CASP8
R-HSA-5621480	Dectin-2 family	0.942887427101958	-0.0588083808851662	10	2	0.000635727908455181	3146	8202	2534,4067	FYN,LYN
R-HSA-418890	Role of second messengers in netrin-1 signaling	0.942887427101958	-0.0588083808851662	10	2	0.000635727908455181	3146	8202	7220,5335	TRPC1,PLCG1
R-HSA-936837	Ion transport by P-type ATPases	0.943145890903962	-0.0585342989788135	49	14	0.00445009535918627	3146	8202	23200,538,57130,476,488,51248,10396,27032,482,148229,481,51076,57205,493	ATP11B,ATP7A,ATP13A1,ATP1A1,ATP2A2,PDZD11,ATP8A1,ATP2C1,ATP1B2,ATP8B3,ATP1B1,CUTC,ATP10D,ATP2B4
R-HSA-1483249	Inositol phosphate metabolism	0.943722042646848	-0.0579236025431519	46	13	0.00413223140495868	3146	8202	3612,5335,3636,64768,11163,9807,4952,253430,808,51477,3706,3613,11165	IMPA1,PLCG1,INPPL1,IPPK,NUDT4,IP6K1,OCRL,IPMK,CALM3,ISYNA1,ITPKA,IMPA2,NUDT3
R-HSA-210500	Glutamate Neurotransmitter Release Cycle	0.944356814588034	-0.0572512026985475	24	6	0.00190718372536554	3146	8202	8497,2744,6616,8500,6857,6505	PPFIA4,GLS,SNAP25,PPFIA1,SYT1,SLC1A1
R-HSA-5365859	RA biosynthesis pathway	0.944356814588034	-0.0572512026985475	24	6	0.00190718372536554	3146	8202	728635,317749,9249,1592,57665,51109	DHRS4L1,DHRS4L2,DHRS3,CYP26A1,RDH14,RDH11
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins	0.944545797747122	-0.0570511043361612	43	12	0.00381436745073109	3146	8202	2778,10681,2785,22841,59345,115,2782,360,5566,8766,2783,5567	GNAS,GNB5,GNG3,RAB11FIP2,GNB4,ADCY9,GNB1,AQP3,PRKACA,RAB11A,GNB2,PRKACB
R-HSA-190370	FGFR1b ligand binding and activation	0.945193848528177	-0.0563652418071757	6	1	0.000317863954227591	3146	8202	2260	FGFR1
R-HSA-2142700	Synthesis of Lipoxins (LX)	0.945193848528177	-0.0563652418071757	6	1	0.000317863954227591	3146	8202	22949	PTGR1
R-HSA-173623	Classical antibody-mediated complement activation	0.945193848528177	-0.0563652418071757	6	1	0.000317863954227591	3146	8202	715	C1R
R-HSA-111957	Cam-PDE 1 activation	0.945193848528177	-0.0563652418071757	6	1	0.000317863954227591	3146	8202	808	CALM3
R-HSA-428808	Na+-dependent glucose transporters	0.945193848528177	-0.0563652418071757	6	1	0.000317863954227591	3146	8202	6526	SLC5A3
R-HSA-189483	Heme degradation	0.945193848528177	-0.0563652418071757	6	1	0.000317863954227591	3146	8202	644	BLVRA
R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	0.94872755355301	-0.0526336095213344	14	3	0.000953591862682772	3146	8202	11001,10858,51302	SLC27A2,CYP46A1,CYP39A1
R-HSA-5682910	LGI-ADAM interactions	0.94872755355301	-0.0526336095213344	14	3	0.000953591862682772	3146	8202	1742,59283,53616	DLG4,CACNG8,ADAM22
R-HSA-500657	Presynaptic function of Kainate receptors	0.949412389484038	-0.0519120231459409	21	5	0.00158931977113795	3146	8202	2782,10681,2785,2783,59345	GNB1,GNB5,GNG3,GNB2,GNB4
R-HSA-5654688	SHC-mediated cascade:FGFR1	0.949412389484038	-0.0519120231459409	21	5	0.00158931977113795	3146	8202	2885,6464,6654,3265,2260	GRB2,SHC1,SOS1,HRAS,FGFR1
R-HSA-196741	Cobalamin (Cbl, vitamin B12) transport and metabolism	0.949412389484038	-0.0519120231459409	21	5	0.00158931977113795	3146	8202	55788,25974,326625,166785,4552	LMBRD1,MMACHC,MMAB,MMAA,MTRR
R-HSA-422356	Regulation of insulin secretion	0.95349734677219	-0.0476186365651571	80	24	0.00762873490146217	3146	8202	2785,8826,23568,2782,3709,6616,3710,5566,2767,2783,2770,2778,5906,291,10681,783,59345,3708,4082,3767,784,10768,2771,5567	GNG3,IQGAP1,ARL2BP,GNB1,ITPR2,SNAP25,ITPR3,PRKACA,GNA11,GNB2,GNAI1,GNAS,RAP1A,SLC25A4,GNB5,CACNB2,GNB4,ITPR1,MARCKS,KCNJ11,CACNB3,AHCYL1,GNAI2,PRKACB
R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle	0.955896612798588	-0.0451055173870648	18	4	0.00127145581691036	3146	8202	8497,6616,8500,6857	PPFIA4,SNAP25,PPFIA1,SYT1
R-HSA-5654704	SHC-mediated cascade:FGFR3	0.955896612798588	-0.0451055173870648	18	4	0.00127145581691036	3146	8202	2885,6464,6654,3265	GRB2,SHC1,SOS1,HRAS
R-HSA-181429	Serotonin Neurotransmitter Release Cycle	0.955896612798588	-0.0451055173870648	18	4	0.00127145581691036	3146	8202	8497,6616,8500,6857	PPFIA4,SNAP25,PPFIA1,SYT1
R-HSA-418457	cGMP effects	0.955896612798588	-0.0451055173870648	18	4	0.00127145581691036	3146	8202	8654,5139,3708,50940	PDE5A,PDE3A,ITPR1,PDE11A
R-HSA-977068	Termination of O-glycan biosynthesis	0.958111314419202	-0.0427913131692758	25	6	0.00190718372536554	3146	8202	6484,256435,10610,6482,6480,6487	ST3GAL4,ST6GALNAC3,ST6GALNAC2,ST3GAL1,ST6GAL1,ST3GAL3
R-HSA-418592	ADP signalling through P2Y purinoceptor 1	0.958111314419202	-0.0427913131692758	25	6	0.00190718372536554	3146	8202	2782,10681,2785,2783,59345,2767	GNB1,GNB5,GNG3,GNB2,GNB4,GNA11
R-HSA-425397	Transport of vitamins, nucleosides, and related molecules	0.958314874064054	-0.0425788764505117	38	10	0.00317863954227591	3146	8202	28231,11046,51248,23443,3177,9197,55343,10999,347734,2030	SLCO4A1,SLC35D2,PDZD11,SLC35A3,SLC29A2,SLC33A1,SLC35C1,SLC27A4,SLC35B2,SLC29A1
R-HSA-376172	DSCAM interactions	0.961782344780869	-0.0389671067420017	11	2	0.000635727908455181	3146	8202	5599,5879	MAPK8,RAC1
R-HSA-1236977	Endosomal/Vacuolar pathway	0.961782344780869	-0.0389671067420017	11	2	0.000635727908455181	3146	8202	567,3105	B2M,HLA-A
R-HSA-5668599	RHO GTPases Activate NADPH Oxidases	0.961782344780869	-0.0389671067420017	11	2	0.000635727908455181	3146	8202	1535,5879	CYBA,RAC1
R-HSA-159854	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	0.961782344780869	-0.0389671067420017	11	2	0.000635727908455181	3146	8202	2677,5045	GGCX,FURIN
R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides	0.962303776200254	-0.0384251024871362	96	29	0.00921805467260013	3146	8202	10723,6520,6559,81539,206358,6522,9990,26503,80024,6505,9057,6541,6533,6509,23657,8671,10479,6575,1468,9497,6548,1836,6510,6558,124935,121260,23315,117247,8501	SLC12A7,SLC3A2,SLC12A3,SLC38A1,SLC36A1,SLC4A2,SLC12A6,SLC17A5,SLC8B1,SLC1A1,SLC7A6,SLC7A1,SLC6A6,SLC1A4,SLC7A11,SLC4A4,SLC9A6,SLC20A2,SLC25A10,SLC4A7,SLC9A1,SLC26A2,SLC1A5,SLC12A2,SLC43A2,SLC15A4,SLC9A8,SLC16A10,SLC43A1
R-HSA-3000171	Non-integrin membrane-ECM interactions	0.965813702298374	-0.0347843181320779	42	11	0.0034965034965035	3146	8202	8573,3915,3673,3688,3913,87,3685,3693,6382,1605,7057	CASK,LAMC1,ITGA2,ITGB1,LAMB2,ACTN1,ITGAV,ITGB5,SDC1,DAG1,THBS1
R-HSA-1566948	Elastic fibre formation	0.965813702298374	-0.0347843181320779	42	11	0.0034965034965035	3146	8202	4239,3688,5045,3678,3685,84695,3693,2192,30008,4054,4015	MFAP4,ITGB1,FURIN,ITGA5,ITGAV,LOXL3,ITGB5,FBLN1,EFEMP2,LTBP3,LOX
R-HSA-174577	Activation of C3 and C5	0.966230958418897	-0.0343523859562921	7	1	0.000317863954227591	3146	8202	717	C2
R-HSA-196791	Vitamin D (calciferol) metabolism	0.966230958418897	-0.0343523859562921	7	1	0.000317863954227591	3146	8202	1591	CYP24A1
R-HSA-3595177	Defective CHSY1 causes TPBS	0.966230958418897	-0.0343523859562921	7	1	0.000317863954227591	3146	8202	10675	CSPG5
R-HSA-429593	Inositol transporters	0.966230958418897	-0.0343523859562921	7	1	0.000317863954227591	3146	8202	6526	SLC5A3
R-HSA-3595174	Defective CHST14 causes EDS, musculocontractural type	0.966230958418897	-0.0343523859562921	7	1	0.000317863954227591	3146	8202	10675	CSPG5
R-HSA-3595172	Defective CHST3 causes SEDCJD	0.966230958418897	-0.0343523859562921	7	1	0.000317863954227591	3146	8202	10675	CSPG5
R-HSA-427601	Multifunctional anion exchangers	0.966230958418897	-0.0343523859562921	7	1	0.000317863954227591	3146	8202	1836	SLC26A2
R-HSA-3000480	Scavenging by Class A Receptors	0.968329165875935	-0.0321832021160764	19	4	0.00127145581691036	3146	8202	811,2495,2512,78989	CALR,FTH1,FTL,COLEC11
R-HSA-888590	GABA synthesis, release, reuptake and degradation	0.968329165875935	-0.0321832021160764	19	4	0.00127145581691036	3146	8202	80331,6616,6857,2571	DNAJC5,SNAP25,SYT1,GAD1
R-HSA-5654699	SHC-mediated cascade:FGFR2	0.968702211989861	-0.0317980290901764	26	6	0.00190718372536554	3146	8202	2885,6464,6654,10818,3265,5781	GRB2,SHC1,SOS1,FRS2,HRAS,PTPN11
R-HSA-163359	Glucagon signaling in metabolic regulation	0.971311673747675	-0.0291078799621728	33	8	0.00254291163382072	3146	8202	2778,2785,59345,115,2782,5566,2783,5567	GNAS,GNG3,GNB4,ADCY9,GNB1,PRKACA,GNB2,PRKACB
R-HSA-1660662	Glycosphingolipid metabolism	0.974566260822762	-0.0257627676587676	40	10	0.00317863954227591	3146	8202	57704,7357,10825,2629,427,285362,25870,2720,2717,3073	GBA2,UGCG,NEU3,GBA,ASAH1,SUMF1,SUMF2,GLB1,GLA,HEXA
R-HSA-2022857	Keratan sulfate degradation	0.974588951375674	-0.025739485210278	12	2	0.000635727908455181	3146	8202	2720,3073	GLB1,HEXA
R-HSA-3656237	Defective EXT2 causes exostoses 2	0.974588951375674	-0.025739485210278	12	2	0.000635727908455181	3146	8202	221914,6382	GPC2,SDC1
R-HSA-211958	Miscellaneous substrates	0.974588951375674	-0.025739485210278	12	2	0.000635727908455181	3146	8202	113612,29785	CYP2U1,CYP2S1
R-HSA-1296346	Tandem pore domain potassium channels	0.974588951375674	-0.025739485210278	12	2	0.000635727908455181	3146	8202	3775,9424	KCNK1,KCNK6
R-HSA-3656253	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	0.974588951375674	-0.025739485210278	12	2	0.000635727908455181	3146	8202	221914,6382	GPC2,SDC1
R-HSA-1482922	Acyl chain remodelling of PI	0.975145646313201	-0.025168438306443	16	3	0.000953591862682772	3146	8202	81579,11145,79143	PLA2G12A,PLA2G16,MBOAT7
R-HSA-163615	PKA activation	0.975145646313201	-0.025168438306443	16	3	0.000953591862682772	3146	8202	5566,5567,115	PRKACA,PRKACB,ADCY9
R-HSA-418346	Platelet homeostasis	0.977440053983159	-0.0228183148515536	78	22	0.00699300699300699	3146	8202	2785,5777,8654,2782,3709,3710,2783,5139,5519,50940,2778,5529,10681,488,6786,59345,3708,5781,5527,84876,5528,493	GNG3,PTPN6,PDE5A,GNB1,ITPR2,ITPR3,GNB2,PDE3A,PPP2R1B,PDE11A,GNAS,PPP2R5E,GNB5,ATP2A2,STIM1,GNB4,ITPR1,PTPN11,PPP2R5C,ORAI1,PPP2R5D,ATP2B4
R-HSA-400451	Free fatty acids regulate insulin secretion	0.979194644179903	-0.0210248368265508	8	1	0.000317863954227591	3146	8202	2767	GNA11
R-HSA-434316	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	0.979194644179903	-0.0210248368265508	8	1	0.000317863954227591	3146	8202	2767	GNA11
R-HSA-804914	Transport of fatty acids	0.979194644179903	-0.0210248368265508	8	1	0.000317863954227591	3146	8202	10999	SLC27A4
R-HSA-444821	Relaxin receptors	0.979194644179903	-0.0210248368265508	8	1	0.000317863954227591	3146	8202	339403	RXFP4
R-HSA-2142670	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	0.979194644179903	-0.0210248368265508	8	1	0.000317863954227591	3146	8202	1545	CYP1B1
R-HSA-389397	Orexin and neuropeptides FF and QRFP bind to their respective receptors	0.979194644179903	-0.0210248368265508	8	1	0.000317863954227591	3146	8202	8620	NPFF
R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	0.980168434922033	-0.0200308497164613	24	5	0.00158931977113795	3146	8202	6342,3295,11001,6256,10005	SCP2,HSD17B4,SLC27A2,RXRA,ACOT8
R-HSA-2129379	Molecules associated with elastic fibres	0.980380883446088	-0.0198141262472832	31	7	0.00222504767959313	3146	8202	3685,2192,3693,4054,30008,4239,3688	ITGAV,FBLN1,ITGB5,LTBP3,EFEMP2,MFAP4,ITGB1
R-HSA-418990	Adherens junctions interactions	0.980380883446088	-0.0198141262472832	31	7	0.00222504767959313	3146	8202	1500,64403,3728,1499,5817,25945,1495	CTNND1,CDH24,JUP,CTNNB1,PVR,PVRL3,CTNNA1
R-HSA-111931	PKA-mediated phosphorylation of CREB	0.982874026754415	-0.017274318873755	17	3	0.000953591862682772	3146	8202	5566,5567,115	PRKACA,PRKACB,ADCY9
R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation	0.982874026754415	-0.017274318873755	17	3	0.000953591862682772	3146	8202	1742,817,10142	DLG4,CAMK2D,AKAP9
R-HSA-1482925	Acyl chain remodelling of PG	0.982874026754415	-0.017274318873755	17	3	0.000953591862682772	3146	8202	81579,79888,254531	PLA2G12A,LPCAT1,LPCAT4
R-HSA-174800	Chylomicron-mediated lipid transport	0.982874026754415	-0.017274318873755	17	3	0.000953591862682772	3146	8202	51128,6382,5034	SAR1B,SDC1,P4HB
R-HSA-75205	Dissolution of Fibrin Clot	0.983196628605171	-0.0169461497382547	13	2	0.000635727908455181	3146	8202	5269,302	SERPINB6,ANXA2
R-HSA-1663150	The activation of arylsulfatases	0.983196628605171	-0.0169461497382547	13	2	0.000635727908455181	3146	8202	25870,285362	SUMF2,SUMF1
R-HSA-877300	Interferon gamma signaling	0.984131531438597	-0.0159957207017677	92	26	0.00826446280991736	3146	8202	23321,85363,5777,23087,567,3661,3663,3105,7341,9021,817,7726,8651,53840,6672,7706,80263,5781,10612,3660,6737,3717,4940,3459,80128,3659	TRIM2,TRIM5,PTPN6,TRIM35,B2M,IRF3,IRF5,HLA-A,SUMO1,SOCS3,CAMK2D,TRIM26,SOCS1,TRIM34,SP100,TRIM25,TRIM45,PTPN11,TRIM3,IRF2,TRIM21,JAK2,OAS3,IFNGR1,TRIM46,IRF1
R-HSA-446728	Cell junction organization	0.984380377415938	-0.0157428942113134	86	24	0.00762873490146217	3146	8202	9076,3987,3728,5817,137075,1495,10979,87,50848,64398,5339,6251,84612,10207,667,29780,64403,7408,1499,25945,3688,5584,1500,1366	CLDN1,LIMS1,JUP,PVR,CLDN23,CTNNA1,FERMT2,ACTN1,F11R,MPP5,PLEC,RSU1,PARD6B,INADL,DST,PARVB,CDH24,VASP,CTNNB1,PVRL3,ITGB1,PRKCI,CTNND1,CLDN7
R-HSA-997272	Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits	0.985682715071301	-0.0144207661535482	25	5	0.00158931977113795	3146	8202	2782,3759,2785,2783,2550	GNB1,KCNJ2,GNG3,GNB2,GABBR1
R-HSA-1296059	G protein gated Potassium channels	0.985682715071301	-0.0144207661535482	25	5	0.00158931977113795	3146	8202	2782,3759,2785,2783,2550	GNB1,KCNJ2,GNG3,GNB2,GABBR1
R-HSA-1296041	Activation of G protein gated Potassium channels	0.985682715071301	-0.0144207661535482	25	5	0.00158931977113795	3146	8202	2782,3759,2785,2783,2550	GNB1,KCNJ2,GNG3,GNB2,GABBR1
R-HSA-977444	GABA B receptor activation	0.986143084854755	-0.0139538184223271	39	9	0.00286077558804832	3146	8202	3759,2785,115,2550,2782,2773,2771,2783,2770	KCNJ2,GNG3,ADCY9,GABBR1,GNB1,GNAI3,GNAI2,GNB2,GNAI1
R-HSA-991365	Activation of GABAB receptors	0.986143084854755	-0.0139538184223271	39	9	0.00286077558804832	3146	8202	3759,2785,115,2550,2782,2773,2771,2783,2770	KCNJ2,GNG3,ADCY9,GABBR1,GNB1,GNAI3,GNAI2,GNB2,GNAI1
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	0.986437854407763	-0.0136549515425614	49	12	0.00381436745073109	3146	8202	5581,5335,115,3708,808,814,3709,3710,10768,5566,2260,5567	PRKCE,PLCG1,ADCY9,ITPR1,CALM3,CAMK4,ITPR2,ITPR3,AHCYL1,PRKACA,FGFR1,PRKACB
R-HSA-194002	Glucocorticoid biosynthesis	0.987182641426244	-0.0129002096300118	9	1	0.000317863954227591	3146	8202	3291	HSD11B2
R-HSA-425561	Sodium/Calcium exchangers	0.987182641426244	-0.0129002096300118	9	1	0.000317863954227591	3146	8202	80024	SLC8B1
R-HSA-391908	Prostanoid ligand receptors	0.987182641426244	-0.0129002096300118	9	1	0.000317863954227591	3146	8202	5734	PTGER4
R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors	0.987182641426244	-0.0129002096300118	9	1	0.000317863954227591	3146	8202	1138	CHRNA5
R-HSA-1296052	Ca2+ activated K+ channels	0.987182641426244	-0.0129002096300118	9	1	0.000317863954227591	3146	8202	3782	KCNN3
R-HSA-159740	Gamma-carboxylation of protein precursors	0.987182641426244	-0.0129002096300118	9	1	0.000317863954227591	3146	8202	2677	GGCX
R-HSA-159782	Removal of aminoterminal propeptides from gamma-carboxylated proteins	0.987182641426244	-0.0129002096300118	9	1	0.000317863954227591	3146	8202	5045	FURIN
R-HSA-5654227	Phospholipase C-mediated cascade; FGFR3	0.987364237717552	-0.0127162724505628	46	11	0.0034965034965035	3146	8202	5581,5335,115,3708,808,814,3709,3710,10768,5566,5567	PRKCE,PLCG1,ADCY9,ITPR1,CALM3,CAMK4,ITPR2,ITPR3,AHCYL1,PRKACA,PRKACB
R-HSA-196071	Metabolism of steroid hormones and vitamin D	0.98758637265369	-0.0124913200533653	36	8	0.00254291163382072	3146	8202	51170,1591,112812,3291,80765,2232,231,2230	HSD17B11,CYP24A1,FDX1L,HSD11B2,STARD5,FDXR,AKR1B1,FDX1
R-HSA-156584	Cytosolic sulfonation of small molecules	0.988269509528564	-0.0117998355091187	18	3	0.000953591862682772	3146	8202	1836,347734,9061	SLC26A2,SLC35B2,PAPSS1
R-HSA-5423646	Aflatoxin activation and detoxification	0.988751306585774	-0.011312438449036	22	4	0.00127145581691036	3146	8202	4258,4259,4257,8574	MGST2,MGST3,MGST1,AKR7A2
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.989164567074133	-0.0108945637559053	33	7	0.00222504767959313	3146	8202	8503,8396,3636,8394,5296,5295,55361	PIK3R3,PIP4K2B,INPPL1,PIP5K1A,PIK3R2,PIK3R1,PI4K2A
R-HSA-1971475	A tetrasaccharide linker sequence is required for GAG synthesis	0.989725691993399	-0.0103274530414691	26	5	0.00158931977113795	3146	8202	221914,283464,6382,11285,10675	GPC2,GXYLT1,SDC1,B4GALT7,CSPG5
R-HSA-111996	Ca-dependent events	0.990866831368875	-0.00917513171511188	30	6	0.00190718372536554	3146	8202	814,808,5566,5594,115,5567	CAMK4,CALM3,PRKACA,MAPK1,ADCY9,PRKACB
R-HSA-420092	Glucagon-type ligand receptors	0.990866831368875	-0.00917513171511188	30	6	0.00190718372536554	3146	8202	2778,2782,10681,2785,2783,59345	GNAS,GNB1,GNB5,GNG3,GNB2,GNB4
R-HSA-913709	O-linked glycosylation of mucins	0.99176574082516	-0.00826834794641301	64	16	0.00508582326764145	3146	8202	10678,6480,29071,63917,256435,51809,10610,6487,84752,56913,6484,8693,146712,55568,6482,374378	B3GNT2,ST6GAL1,C1GALT1C1,GALNT11,ST6GALNAC3,GALNT7,ST6GALNAC2,ST3GAL3,B3GNT9,C1GALT1,ST3GAL4,GALNT4,B3GNTL1,GALNT10,ST3GAL1,GALNT18
R-HSA-445717	Aquaporin-mediated transport	0.991860392490718	-0.00817291497742731	51	12	0.00381436745073109	3146	8202	2778,10681,2785,22841,59345,115,2782,360,5566,8766,2783,5567	GNAS,GNB5,GNG3,RAB11FIP2,GNB4,ADCY9,GNB1,AQP3,PRKACA,RAB11A,GNB2,PRKACB
R-HSA-416700	Other semaphorin interactions	0.992008323957834	-0.00802378064594348	19	3	0.000953591862682772	3146	8202	8482,23129,3688	SEMA7A,PLXND1,ITGB1
R-HSA-3560801	Defective B3GAT3 causes JDSSDHD	0.992008323957834	-0.00802378064594348	19	3	0.000953591862682772	3146	8202	221914,6382,10675	GPC2,SDC1,CSPG5
R-HSA-3560783	Defective B4GALT7 causes EDS, progeroid type	0.992008323957834	-0.00802378064594348	19	3	0.000953591862682772	3146	8202	221914,6382,10675	GPC2,SDC1,CSPG5
R-HSA-190861	Gap junction assembly	0.992008323957834	-0.00802378064594348	19	3	0.000953591862682772	3146	8202	2707,375519,10052	GJB3,GJB7,GJC1
R-HSA-4420332	Defective B3GALT6 causes EDSP2 and SEMDJL1	0.992008323957834	-0.00802378064594348	19	3	0.000953591862682772	3146	8202	221914,6382,10675	GPC2,SDC1,CSPG5
R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade	0.992014548151326	-0.00801750632967457	34	7	0.00222504767959313	3146	8202	808,2782,4836,2339,10681,23173,9397	CALM3,GNB1,NMT1,FNTA,GNB5,METAP1,NMT2
R-HSA-209968	Thyroxine biosynthesis	0.992104331906102	-0.0079270039351456	10	1	0.000317863954227591	3146	8202	1734	DIO2
R-HSA-419812	Calcitonin-like ligand receptors	0.992104331906102	-0.0079270039351456	10	1	0.000317863954227591	3146	8202	133	ADM
R-HSA-1300644	Interaction With The Zona Pellucida	0.992104331906102	-0.0079270039351456	10	1	0.000317863954227591	3146	8202	7784	ZP3
R-HSA-1433617	Regulation of signaling by NODAL	0.992104331906102	-0.0079270039351456	10	1	0.000317863954227591	3146	8202	92	ACVR2A
R-HSA-170660	Adenylate cyclase activating pathway	0.992104331906102	-0.0079270039351456	10	1	0.000317863954227591	3146	8202	115	ADCY9
R-HSA-2161522	Abacavir transport and metabolism	0.992104331906102	-0.0079270039351456	10	1	0.000317863954227591	3146	8202	9429	ABCG2
R-HSA-5687613	Diseases associated with surfactant metabolism	0.992104331906102	-0.0079270039351456	10	1	0.000317863954227591	3146	8202	7270	TTF1
R-HSA-421270	Cell-cell junction organization	0.992203430253046	-0.0078271219018074	61	15	0.00476795931341386	3146	8202	9076,64403,3728,1499,5817,137075,25945,1495,5584,1500,50848,64398,1366,84612,10207	CLDN1,CDH24,JUP,CTNNB1,PVR,CLDN23,PVRL3,CTNNA1,PRKCI,CTNND1,F11R,MPP5,CLDN7,PARD6B,INADL
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.992203430253046	-0.0078271219018074	61	15	0.00476795931341386	3146	8202	2885,8660,685,2534,5296,5295,5781,2069,8503,4254,2064,2065,10818,2549,2260	GRB2,IRS2,BTC,FYN,PIK3R2,PIK3R1,PTPN11,EREG,PIK3R3,KITLG,ERBB2,ERBB3,FRS2,GAB1,FGFR1
R-HSA-5654228	Phospholipase C-mediated cascade; FGFR4	0.99255033983604	-0.00747754746919526	48	11	0.0034965034965035	3146	8202	5581,5335,115,3708,808,814,3709,3710,10768,5566,5567	PRKCE,PLCG1,ADCY9,ITPR1,CALM3,CAMK4,ITPR2,ITPR3,AHCYL1,PRKACA,PRKACB
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	0.992668151674113	-0.0073588584294604	27	5	0.00158931977113795	3146	8202	808,5335,3636,3706,4952	CALM3,PLCG1,INPPL1,ITPKA,OCRL
R-HSA-194223	HDL-mediated lipid transport	0.992752661854523	-0.00727372768046673	15	2	0.000635727908455181	3146	8202	3931,5360	LCAT,PLTP
R-HSA-1296065	Inwardly rectifying K+ channels	0.993383458863262	-0.00663852748107653	31	6	0.00190718372536554	3146	8202	2782,3767,3759,2785,2783,2550	GNB1,KCNJ11,KCNJ2,GNG3,GNB2,GABBR1
R-HSA-2514856	The phototransduction cascade	0.994145279853735	-0.00587192621092417	35	7	0.00222504767959313	3146	8202	808,2782,4836,2339,10681,23173,9397	CALM3,GNB1,NMT1,FNTA,GNB5,METAP1,NMT2
R-HSA-194068	Bile acid and bile salt metabolism	0.994145279853735	-0.00587192621092417	35	7	0.00222504767959313	3146	8202	6342,3295,11001,10858,51302,6256,10005	SCP2,HSD17B4,SLC27A2,CYP46A1,CYP39A1,RXRA,ACOT8
R-HSA-392154	Nitric oxide stimulates guanylate cyclase	0.994521007457308	-0.00549405727389751	24	4	0.00127145581691036	3146	8202	8654,5139,3708,50940	PDE5A,PDE3A,ITPR1,PDE11A
R-HSA-166663	Initial triggering of complement	0.994582015978242	-0.00543271452771116	20	3	0.000953591862682772	3146	8202	715,717,1675	C1R,C2,CFD
R-HSA-111933	Calmodulin induced events	0.994795173283665	-0.00521841901111486	28	5	0.00158931977113795	3146	8202	814,808,5566,5567,115	CAMK4,CALM3,PRKACA,PRKACB,ADCY9
R-HSA-111997	CaM pathway	0.994795173283665	-0.00521841901111486	28	5	0.00158931977113795	3146	8202	814,808,5566,5567,115	CAMK4,CALM3,PRKACA,PRKACB,ADCY9
R-HSA-879518	Transport of organic anions	0.995136530620946	-0.00487533453242723	11	1	0.000317863954227591	3146	8202	28231	SLCO4A1
R-HSA-71288	Creatine metabolism	0.995136530620946	-0.00487533453242723	11	1	0.000317863954227591	3146	8202	1152	CKB
R-HSA-2485179	Activation of the phototransduction cascade	0.995136530620946	-0.00487533453242723	11	1	0.000317863954227591	3146	8202	2782	GNB1
R-HSA-211999	CYP2E1 reactions	0.995136530620946	-0.00487533453242723	11	1	0.000317863954227591	3146	8202	29785	CYP2S1
R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	0.995136530620946	-0.00487533453242723	11	1	0.000317863954227591	3146	8202	1138	CHRNA5
R-HSA-1839122	Signaling by activated point mutants of FGFR1	0.995136530620946	-0.00487533453242723	11	1	0.000317863954227591	3146	8202	2260	FGFR1
R-HSA-73923	Lipid digestion, mobilization, and transport	0.995584560206742	-0.0044252166375344	60	14	0.00445009535918627	3146	8202	3931,2170,51128,91289,5034,5500,64788,857,5499,5360,6382,5566,5501,5567	LCAT,FABP3,SAR1B,LMF2,P4HB,PPP1CB,LMF1,CAV1,PPP1CA,PLTP,SDC1,PRKACA,PPP1CC,PRKACB
R-HSA-2672351	Stimuli-sensing channels	0.996047196178718	-0.00396063679860254	99	26	0.00826446280991736	3146	8202	55129,1182,7311,28962,1831,5894,55283,80727,7316,65125,6337,9311,1186,6233,2281,6717,1185,6446,7220,11059,57719,7314,150159,53373,57578,26133	ANO10,CLCN3,UBA52,OSTM1,TSC22D3,RAF1,MCOLN3,TTYH3,UBC,WNK1,SCNN1A,ASIC3,CLCN7,RPS27A,FKBP1B,SRI,CLCN6,SGK1,TRPC1,WWP1,ANO8,UBB,SLC9B1,TPCN1,UNC79,TRPC4AP
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	0.996231748225255	-0.00377536952206632	40	8	0.00254291163382072	3146	8202	10525,811,2495,2512,10808,3320,78989,4035	HYOU1,CALR,FTH1,FTL,HSPH1,HSP90AA1,COLEC11,LRP1
R-HSA-1650814	Collagen biosynthesis and modifying enzymes	0.996295148103492	-0.00371173185837875	64	15	0.00476795931341386	3146	8202	5479,7092,5352,10536,5034,84570,1291,1289,79709,1294,8985,1288,10491,1303,7093	PPIB,TLL1,PLOD2,P3H3,P4HB,COL25A1,COL6A1,COL5A1,COLGALT1,COL7A1,PLOD3,COL4A6,CRTAP,COL12A1,TLL2
R-HSA-382556	ABC-family proteins mediated transport	0.996710848885308	-0.00329457226280096	44	9	0.00286077558804832	3146	8202	5824,1968,8504,89845,1965,23456,215,3767,10347	PEX19,EIF2S3,PEX3,ABCC10,EIF2S1,ABCB10,ABCD1,KCNJ11,ABCA7
R-HSA-5654221	Phospholipase C-mediated cascade; FGFR2	0.996740608516931	-0.003264714869971	51	11	0.0034965034965035	3146	8202	5581,5335,115,3708,808,814,3709,3710,10768,5566,5567	PRKCE,PLCG1,ADCY9,ITPR1,CALM3,CAMK4,ITPR2,ITPR3,AHCYL1,PRKACA,PRKACB
R-HSA-1475029	Reversible hydration of carbon dioxide	0.997004492390962	-0.00300000312176209	12	1	0.000317863954227591	3146	8202	377677	CA13
R-HSA-190373	FGFR1c ligand binding and activation	0.997004492390962	-0.00300000312176209	12	1	0.000317863954227591	3146	8202	2260	FGFR1
R-HSA-71384	Ethanol oxidation	0.997004492390962	-0.00300000312176209	12	1	0.000317863954227591	3146	8202	128	ADH5
R-HSA-2168880	Scavenging of heme from plasma	0.997004492390962	-0.00300000312176209	12	1	0.000317863954227591	3146	8202	4035	LRP1
R-HSA-417957	P2Y receptors	0.997004492390962	-0.00300000312176209	12	1	0.000317863954227591	3146	8202	5029	P2RY2
R-HSA-166786	Creation of C4 and C2 activators	0.997004492390962	-0.00300000312176209	12	1	0.000317863954227591	3146	8202	715	C1R
R-HSA-622323	Presynaptic nicotinic acetylcholine receptors	0.997004492390962	-0.00300000312176209	12	1	0.000317863954227591	3146	8202	1138	CHRNA5
R-HSA-211979	Eicosanoids	0.997004492390962	-0.00300000312176209	12	1	0.000317863954227591	3146	8202	6916	TBXAS1
R-HSA-432047	Passive transport by Aquaporins	0.997004492390962	-0.00300000312176209	12	1	0.000317863954227591	3146	8202	360	AQP3
R-HSA-397014	Muscle contraction	0.997131179398942	-0.00287294355410789	65	15	0.00476795931341386	3146	8202	10398,10580,7170,309,7169,7171,59,4637,808,302,7168,7414,3693,4636,140465	MYL9,SORBS1,TPM3,ANXA6,TPM2,TPM4,ACTA2,MYL6,CALM3,ANXA2,TPM1,VCL,ITGB5,MYL5,MYL6B
R-HSA-174824	Lipoprotein metabolism	0.997414389449395	-0.00258895901469323	30	5	0.00158931977113795	3146	8202	3931,51128,5360,6382,5034	LCAT,SAR1B,PLTP,SDC1,P4HB
R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The  Postsynaptic Cell	0.997731170107093	-0.00227140758708611	142	39	0.012396694214876	3146	8202	10142,673,1173,2785,84254,5894,2550,808,814,2782,5566,2783,9463,59283,6196,4193,10681,1138,115,1739,163,4646,1741,2771,5567,5170,6237,3759,1742,2773,2770,817,59345,160,5594,3265,23229,1175,6197	AKAP9,BRAF,AP2M1,GNG3,CAMKK1,RAF1,GABBR1,CALM3,CAMK4,GNB1,PRKACA,GNB2,PICK1,CACNG8,RPS6KA2,MDM2,GNB5,CHRNA5,ADCY9,DLG1,AP2B1,MYO6,DLG3,GNAI2,PRKACB,PDPK1,RRAS,KCNJ2,DLG4,GNAI3,GNAI1,CAMK2D,GNB4,AP2A1,MAPK1,HRAS,ARHGEF9,AP2S1,RPS6KA3
R-HSA-1442490	Collagen degradation	0.997757244966371	-0.00224527377535117	38	7	0.00222504767959313	3146	8202	4324,85007,6868,102,84570,1303,5045	MMP15,PHYKPL,ADAM17,ADAM10,COL25A1,COL12A1,FURIN
R-HSA-76002	Platelet activation, signaling and aggregation	0.998105084881262	-0.00189671274164601	230	68	0.0216147488874762	3146	8202	391,2785,5894,5879,2782,2812,8527,3709,4067,57406,2783,5906,6464,10487,5296,8503,7414,151,207,208,5777,87,7422,3710,2773,7114,2770,2534,1398,26090,59345,226,1675,5590,81,409,10672,5594,967,7410,5552,808,5478,7057,5581,10681,5781,3717,2771,7423,5170,387,6654,9948,5295,5908,813,5747,6810,9564,2767,388,5595,2885,2768,221955,3708,7534	RHOG,GNG3,RAF1,RAC1,GNB1,GP1BB,DGKD,ITPR2,LYN,ABHD6,GNB2,RAP1A,SHC1,CAP1,PIK3R2,PIK3R3,VCL,ADRA2B,AKT1,AKT2,PTPN6,ACTN1,VEGFA,ITPR3,GNAI3,TMSB4X,GNAI1,FYN,CRK,ABHD12,GNB4,ALDOA,CFD,PRKCZ,ACTN4,ARRB2,GNA13,MAPK1,CD63,VAV2,SRGN,CALM3,PPIA,THBS1,PRKCE,GNB5,PTPN11,JAK2,GNAI2,VEGFB,PDPK1,RHOA,SOS1,WDR1,PIK3R1,RAP1B,CALU,PTK2,STX4,BCAR1,GNA11,RHOB,MAPK3,GRB2,GNA12,DAGLB,ITPR1,YWHAZ
R-HSA-400511	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	0.998155147708518	-0.0018465561273437	13	1	0.000317863954227591	3146	8202	2626	GATA4
R-HSA-977441	GABA A receptor activation	0.998155147708518	-0.0018465561273437	13	1	0.000317863954227591	3146	8202	23229	ARHGEF9
R-HSA-209822	Glycoprotein hormones	0.998155147708518	-0.0018465561273437	13	1	0.000317863954227591	3146	8202	94027	CGB7
R-HSA-109582	Hemostasis	0.998320548396764	-0.001680863463068	515	167	0.0530832803560076	3146	8202	2782,2812,8358,50848,8350,11004,3709,25942,57406,5519,2152,3833,1387,7465,5906,6786,5296,3660,3835,64147,151,55604,5567,8352,6520,208,56992,857,7422,2773,7114,2770,5335,64145,2627,1398,59345,226,1675,25970,3688,81,5527,3065,5269,409,140628,5528,23764,3066,7410,808,3831,10461,7057,5581,23657,2624,23759,829,84876,2771,7423,8968,10112,9948,221037,5908,8654,830,2767,388,50940,8165,2778,3708,961,2886,6566,11127,7534,91768,3659,8354,2033,391,2785,5894,5879,9123,8527,3661,161882,4067,5566,2783,5139,4097,23028,90952,4778,6464,10487,488,8503,7414,9732,207,5777,5868,87,481,3710,3796,55669,5889,5529,2534,26090,8351,3673,5590,482,302,3020,5594,10672,967,5552,89953,11311,682,5478,9057,25,3799,10681,5781,653604,3717,50808,5170,387,2626,6654,5295,813,3678,23186,5747,7525,6810,3832,9564,8357,5595,9927,2885,2768,81930,221955,2734,3685,832,3265,493,11216	GNB1,GP1BB,HIST1H3B,F11R,HIST1H3A,KIF2C,ITPR2,SIN3A,ABHD6,PPP2R1B,F3,KIFC1,CREBBP,WEE1,RAP1A,STIM1,PIK3R2,IRF2,KIF22,KIF9,ADRA2B,LRRC16A,PRKACB,HIST1H3C,SLC3A2,AKT2,KIF15,CAV1,VEGFA,GNAI3,TMSB4X,GNAI1,PLCG1,RBSN,GATA6,CRK,GNB4,ALDOA,CFD,SH2B1,ITGB1,ACTN4,PPP2R5C,HDAC1,SERPINB6,ARRB2,GATA5,PPP2R5D,MAFF,HDAC2,VAV2,CALM3,KLC1,MERTK,THBS1,PRKCE,SLC7A11,GATA2,PPIL2,CAPZA1,ORAI1,GNAI2,VEGFB,HIST1H3F,KIF20A,WDR1,JMJD1C,RAP1B,PDE5A,CAPZA2,GNA11,RHOB,PDE11A,AKAP1,GNAS,ITPR1,CD47,GRB7,SLC16A1,KIF3A,YWHAZ,CABLES1,IRF1,HIST1H3I,EP300,RHOG,GNG3,RAF1,RAC1,SLC16A3,DGKD,IRF3,ZFPM1,LYN,PRKACA,GNB2,PDE3A,MAFG,KDM1A,ESAM,NFE2,SHC1,CAP1,ATP2A2,PIK3R3,VCL,DOCK4,AKT1,PTPN6,RAB5A,ACTN1,ATP1B1,ITPR3,KIF2A,MFN1,RAD51C,PPP2R5E,FYN,ABHD12,HIST1H3D,ITGA2,PRKCZ,ATP1B2,ANXA2,H3F3A,MAPK1,GNA13,CD63,SRGN,KLC4,VPS45,BSG,PPIA,SLC7A6,ABL1,KIF5B,GNB5,PTPN11,HIST2H3D,JAK2,AK3,PDPK1,RHOA,GATA4,SOS1,PIK3R1,CALU,ITGA5,RCOR1,PTK2,YES1,STX4,KIF11,BCAR1,HIST1H3H,MAPK3,MFN2,GRB2,GNA12,KIF18A,DAGLB,GLG1,ITGAV,CAPZB,HRAS,ATP2B4,AKAP10
R-HSA-400508	Incretin synthesis, secretion, and inactivation	0.998353839966246	-0.00164751644396589	23	3	0.000953591862682772	3146	8202	1499,2626,6934	CTNNB1,GATA4,TCF7L2
R-HSA-389948	PD-1 signaling	0.998353839966246	-0.00164751644396589	23	3	0.000953591862682772	3146	8202	29126,5777,5781	CD274,PTPN6,PTPN11
R-HSA-112310	Neurotransmitter Release Cycle	0.998424224476648	-0.00157701836339852	50	10	0.00317863954227591	3146	8202	2744,8573,80331,8497,6616,8500,6857,2571,55327,6505	GLS,CASK,DNAJC5,PPFIA4,SNAP25,PPFIA1,SYT1,GAD1,LIN7C,SLC1A1
R-HSA-425407	SLC-mediated transmembrane transport	0.998523297204352	-0.00147779419580292	264	79	0.0251112523839797	3146	8202	11046,6517,23511,29988,9123,9197,2030,348995,347734,80024,27173,148867,5002,23446,57122,154091,9972,1836,81929,6584,6520,6559,81539,64116,3177,55343,4891,9631,26503,8021,6541,5903,23443,10479,6575,9497,861,23315,10723,6526,8480,254428,6522,9990,6505,129401,23165,9883,9057,1317,23657,6509,55676,1468,57153,10999,6548,6558,3101,79902,206358,51248,92579,7175,28231,6533,8671,11182,6566,23636,3098,55356,6510,7779,124935,6583,121260,117247,8501	SLC35D2,SLC2A4,NUP188,SLC2A8,SLC16A3,SLC33A1,SLC29A1,NUP43,SLC35B2,SLC8B1,SLC39A1,SLC30A7,SLC22A18,SLC44A1,NUP107,SLC2A12,NUP153,SLC26A2,SEH1L,SLC22A5,SLC3A2,SLC12A3,SLC38A1,SLC39A8,SLC29A2,SLC35C1,SLC11A2,NUP155,SLC17A5,NUP214,SLC7A1,RANBP2,SLC35A3,SLC9A6,SLC20A2,SLC4A7,RUNX1,SLC9A8,SLC12A7,SLC5A3,RAE1,SLC41A1,SLC4A2,SLC12A6,SLC1A1,NUP35,NUP205,POM121,SLC7A6,SLC31A1,SLC7A11,SLC1A4,SLC30A6,SLC25A10,SLC44A2,SLC27A4,SLC9A1,SLC12A2,HK3,NUP85,SLC36A1,PDZD11,G6PC3,TPR,SLCO4A1,SLC6A6,SLC4A4,SLC2A6,SLC16A1,NUP62,HK1,SLC22A15,SLC1A5,SLC30A1,SLC43A2,SLC22A4,SLC15A4,SLC16A10,SLC43A1
R-HSA-202433	Generation of second messenger molecules	0.998737457528322	-0.00126334014989725	32	5	0.00158931977113795	3146	8202	55740,5335,7408,4690,5062	ENAH,PLCG1,VASP,NCK1,PAK2
R-HSA-156580	Phase II conjugation	0.998787022803983	-0.00121371344828814	98	24	0.00762873490146217	3146	8202	26873,2954,7360,2729,4259,2948,7358,2952,347734,4258,4257,4144,2937,4552,10327,373156,79017,119391,9,9061,1836,55748,2098,7172	OPLAH,GSTZ1,UGP2,GCLC,MGST3,GSTM4,UGDH,GSTT1,SLC35B2,MGST2,MGST1,MAT2A,GSS,MTRR,AKR1A1,GSTK1,GGCT,GSTO2,NAT1,PAPSS1,SLC26A2,CNDP2,ESD,TPMT
R-HSA-181431	Acetylcholine Binding And Downstream Events	0.998863891790545	-0.00113675406961066	14	1	0.000317863954227591	3146	8202	1138	CHRNA5
R-HSA-629602	Activation of Nicotinic Acetylcholine Receptors	0.998863891790545	-0.00113675406961066	14	1	0.000317863954227591	3146	8202	1138	CHRNA5
R-HSA-622327	Postsynaptic nicotinic acetylcholine receptors	0.998863891790545	-0.00113675406961066	14	1	0.000317863954227591	3146	8202	1138	CHRNA5
R-HSA-445095	Interaction between L1 and Ankyrins	0.999161724737885	-0.000838626811299855	29	4	0.00127145581691036	3146	8202	6324,287,6711,6709	SCN1B,ANK2,SPTBN1,SPTAN1
R-HSA-210745	Regulation of gene expression in beta cells	0.999165290672382	-0.000835057891428594	20	2	0.000635727908455181	3146	8202	207,208	AKT1,AKT2
R-HSA-381771	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	0.999165290672382	-0.000835057891428594	20	2	0.000635727908455181	3146	8202	1499,6934	CTNNB1,TCF7L2
R-HSA-3295583	TRP channels	0.999269145985581	-0.000731121218413566	25	3	0.000953591862682772	3146	8202	7220,26133,55283	TRPC1,TRPC4AP,MCOLN3
R-HSA-209952	Peptide hormone biosynthesis	0.99930040821909	-0.000699836609433724	15	1	0.000317863954227591	3146	8202	94027	CGB7
R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	0.99930040821909	-0.000699836609433724	15	1	0.000317863954227591	3146	8202	6256	RXRA
R-HSA-391903	Eicosanoid ligand-binding receptors	0.99930040821909	-0.000699836609433724	15	1	0.000317863954227591	3146	8202	5734	PTGER4
R-HSA-159418	Recycling of bile acids and salts	0.99930040821909	-0.000699836609433724	15	1	0.000317863954227591	3146	8202	6256	RXRA
R-HSA-156588	Glucuronidation	0.999462355345406	-0.000537789237306398	21	2	0.000635727908455181	3146	8202	7360,7358	UGP2,UGDH
R-HSA-211897	Cytochrome P450 - arranged by substrate type	0.999505543331086	-0.000494578952924304	61	12	0.00381436745073109	3146	8202	1591,112812,10858,29785,2232,6256,6916,113612,51302,1592,2230,1545	CYP24A1,FDX1L,CYP46A1,CYP2S1,FDXR,RXRA,TBXAS1,CYP2U1,CYP39A1,CYP26A1,FDX1,CYP1B1
R-HSA-3560782	Diseases associated with glycosaminoglycan metabolism	0.999515236068755	-0.0004848814672658	26	3	0.000953591862682772	3146	8202	221914,6382,10675	GPC2,SDC1,CSPG5
R-HSA-3781865	Diseases of glycosylation	0.999515236068755	-0.0004848814672658	26	3	0.000953591862682772	3146	8202	221914,6382,10675	GPC2,SDC1,CSPG5
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	0.999539026036056	-0.00046108024510526	54	10	0.00317863954227591	3146	8202	667,1294,5339,7092,84695,1288,1291,1289,4015,7093	DST,COL7A1,PLEC,TLL1,LOXL3,COL4A6,COL6A1,COL5A1,LOX,TLL2
R-HSA-2022377	Metabolism of Angiotensinogen to Angiotensins	0.999569238778709	-0.000430854025558347	16	1	0.000317863954227591	3146	8202	10159	ATP6AP2
R-HSA-418038	Nucleotide-like (purinergic) receptors	0.999569238778709	-0.000430854025558347	16	1	0.000317863954227591	3146	8202	5029	P2RY2
R-HSA-190242	FGFR1 ligand binding and activation	0.999569238778709	-0.000430854025558347	16	1	0.000317863954227591	3146	8202	2260	FGFR1
R-HSA-1474290	Collagen formation	0.999600071148638	-0.000400008844232918	86	19	0.00603941513032422	3146	8202	5479,7092,10536,79709,1294,5339,84695,1303,667,5034,5352,84570,1289,1291,8985,1288,10491,4015,7093	PPIB,TLL1,P3H3,COLGALT1,COL7A1,PLEC,LOXL3,COL12A1,DST,P4HB,PLOD2,COL25A1,COL5A1,COL6A1,PLOD3,COL4A6,CRTAP,LOX,TLL2
R-HSA-2453902	The canonical retinoid cycle in rods (twilight vision)	0.999654401569182	-0.000345658163718465	22	2	0.000635727908455181	3146	8202	222236,51109	NAPEPLD,RDH11
R-HSA-983712	Ion channel transport	0.999655610240797	-0.000344449074975274	198	54	0.0171646535282899	3146	8202	55129,538,523,1831,10396,5894,55283,537,51076,80727,23200,65125,9311,6337,488,1186,1185,6717,6446,23545,7220,11059,57719,51606,7314,529,9114,53373,57578,9550,1182,7311,57130,51248,28962,27032,535,148229,481,57205,7316,51382,476,10312,6233,2281,527,482,528,150159,23229,8992,493,26133	ANO10,ATP7A,ATP6V1A,TSC22D3,ATP8A1,RAF1,MCOLN3,ATP6AP1,CUTC,TTYH3,ATP11B,WNK1,ASIC3,SCNN1A,ATP2A2,CLCN7,CLCN6,SRI,SGK1,ATP6V0A2,TRPC1,WWP1,ANO8,ATP6V1H,UBB,ATP6V1E1,ATP6V0D1,TPCN1,UNC79,ATP6V1G1,CLCN3,UBA52,ATP13A1,PDZD11,OSTM1,ATP2C1,ATP6V0A1,ATP8B3,ATP1B1,ATP10D,UBC,ATP6V1D,ATP1A1,TCIRG1,RPS27A,FKBP1B,ATP6V0C,ATP1B2,ATP6V1C1,SLC9B1,ARHGEF9,ATP6V0E1,ATP2B4,TRPC4AP
R-HSA-2142753	Arachidonic acid metabolism	0.999663867711202	-0.000336188793918345	55	10	0.00317863954227591	3146	8202	127281,5743,6916,113612,10728,22949,9536,2876,1545,2879	FAM213B,PTGS2,TBXAS1,CYP2U1,PTGES3,PTGR1,PTGES,GPX1,CYP1B1,GPX4
R-HSA-977443	GABA receptor activation	0.999663867711202	-0.000336188793918345	55	10	0.00317863954227591	3146	8202	3759,2785,115,2550,2782,2773,2771,23229,2783,2770	KCNJ2,GNG3,ADCY9,GABBR1,GNB1,GNAI3,GNAI2,ARHGEF9,GNB2,GNAI1
R-HSA-373080	Class B/2 (Secretin family receptors)	0.999692831483397	-0.000307215702514792	87	19	0.00603941513032422	3146	8202	7480,2785,8322,8325,7976,5727,2782,7481,2535,2783,133,8324,7474,2778,10681,59345,8326,7855,8321	WNT10B,GNG3,FZD4,FZD8,FZD3,PTCH1,GNB1,WNT11,FZD2,GNB2,ADM,FZD7,WNT5A,GNAS,GNB5,GNB4,FZD9,FZD5,FZD1
R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.999733766259285	-0.000266269187208812	101	23	0.00731087094723458	3146	8202	6526,6517,29988,254428,64116,9123,4891,27173,148867,1317,6533,5002,55676,23446,11182,6566,57153,154091,861,55356,7779,6583,6584	SLC5A3,SLC2A4,SLC2A8,SLC41A1,SLC39A8,SLC16A3,SLC11A2,SLC39A1,SLC30A7,SLC31A1,SLC6A6,SLC22A18,SLC30A6,SLC44A1,SLC2A6,SLC16A1,SLC44A2,SLC2A12,RUNX1,SLC22A15,SLC30A1,SLC22A4,SLC22A5
R-HSA-422085	Synthesis, secretion, and deacylation of Ghrelin	0.999734786670032	-0.000265248505242725	17	1	0.000317863954227591	3146	8202	9314	KLF4
R-HSA-186712	Regulation of beta-cell development	0.999739670642785	-0.000260363248784543	32	4	0.00127145581691036	3146	8202	3280,3516,207,208	HES1,RBPJ,AKT1,AKT2
R-HSA-419037	NCAM1 interactions	0.999802531285759	-0.000197488213754352	37	5	0.00158931977113795	3146	8202	784,785,8913,783,1291	CACNB3,CACNB4,CACNA1G,CACNB2,COL6A1
R-HSA-209776	Amine-derived hormones	0.999836724500996	-0.000163288829899425	18	1	0.000317863954227591	3146	8202	1734	DIO2
R-HSA-977606	Regulation of Complement cascade	0.999857980678295	-0.00014202940740362	24	2	0.000635727908455181	3146	8202	966,717	CD59,C2
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.999871881164274	-0.000128127043644789	424	128	0.0406865861411316	3146	8202	161742,10142,685,200734,9462,2785,4763,5683,5786,8826,5894,5037,5604,2064,2782,8527,5720,3709,57406,2783,23566,5519,5906,6869,5696,6196,5687,6464,5688,6711,8620,5296,5701,10213,23198,8503,7414,10818,7311,9978,10287,5695,8452,1742,283455,1846,3710,2260,8660,5529,1907,817,2534,5719,26090,5706,6233,80824,5709,59345,4296,4254,5527,5690,5705,9861,5536,409,5594,5700,5528,5711,1844,5689,9170,5693,673,7204,5245,8649,5713,808,5716,10256,5997,5715,9491,1847,5581,5708,10681,3717,5717,2065,5598,7314,5686,5694,5029,1843,6709,5692,6654,5295,5702,5908,8437,5747,5710,5605,2767,5685,5691,7316,5921,5595,5704,2885,115557,221955,3708,84078,2069,152559,84292,3265,6197,3269	SPRED1,AKAP9,BTC,SPRED2,RASAL2,GNG3,NF1,PSMA2,PTPRA,IQGAP1,RAF1,PEBP1,MAP2K1,ERBB2,GNB1,DGKD,PSME1,ITPR2,ABHD6,GNB2,LPAR3,PPP2R1B,RAP1A,TACR1,PSMB8,RPS6KA2,PSMA6,SHC1,PSMA7,SPTBN1,NPFF,PIK3R2,PSMC2,PSMD14,PSME4,PIK3R3,VCL,FRS2,UBA52,RBX1,RGS19,PSMB7,CUL3,DLG4,KSR2,DUSP4,ITPR3,FGFR1,IRS2,PPP2R5E,EDN2,CAMK2D,FYN,PSMD13,ABHD12,PSMC6,RPS27A,DUSP16,PSMD3,GNB4,MAP3K11,KITLG,PPP2R5C,PSMB2,PSMC5,PSMD6,PPP5C,ARRB2,MAPK1,PSMC1,PPP2R5D,PSMD5,DUSP2,PSMB1,LPAR2,PSMB5,BRAF,TRIO,PHB,LAMTOR3,PSMD7,CALM3,PSMD10,CNKSR1,RGS2,PSMD9,PSMF1,DUSP5,PRKCE,PSMD2,GNB5,JAK2,PSMD11,ERBB3,MAPK7,UBB,PSMA5,PSMB6,P2RY2,DUSP1,SPTAN1,PSMB4,SOS1,PIK3R1,PSMC3,RAP1B,RASAL1,PTK2,PSMD4,MAP2K2,GNA11,PSMA4,PSMB3,UBC,RASA1,MAPK3,PSMC4,GRB2,ARHGEF25,DAGLB,ITPR1,KBTBD7,EREG,PAQR3,WDR83,HRAS,RPS6KA3,HRH1
R-HSA-390522	Striated Muscle Contraction	0.99988233180961	-0.000117675113834752	34	4	0.00127145581691036	3146	8202	7168,7170,7169,7171	TPM1,TPM3,TPM2,TPM4
R-HSA-112315	Transmission across Chemical Synapses	0.999886560286295	-0.000113446148476497	210	56	0.0178003814367451	3146	8202	11094,10142,673,80331,1173,2785,84254,5894,2550,808,814,2782,8500,785,5566,2783,2752,6505,9463,59283,4193,6196,10681,1138,783,115,1739,163,1741,4646,2571,2771,5567,5170,8573,6237,3759,81539,1742,8497,6616,6857,55327,2773,2770,2744,817,160,59345,784,5594,3265,1175,23229,6197,781	CACFD1,AKAP9,BRAF,DNAJC5,AP2M1,GNG3,CAMKK1,RAF1,GABBR1,CALM3,CAMK4,GNB1,PPFIA1,CACNB4,PRKACA,GNB2,GLUL,SLC1A1,PICK1,CACNG8,MDM2,RPS6KA2,GNB5,CHRNA5,CACNB2,ADCY9,DLG1,AP2B1,DLG3,MYO6,GAD1,GNAI2,PRKACB,PDPK1,CASK,RRAS,KCNJ2,SLC38A1,DLG4,PPFIA4,SNAP25,SYT1,LIN7C,GNAI3,GNAI1,GLS,CAMK2D,AP2A1,GNB4,CACNB3,MAPK1,HRAS,AP2S1,ARHGEF9,RPS6KA3,CACNA2D1
R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters	0.999899489012753	-0.000100516038815137	19	1	0.000317863954227591	3146	8202	6533	SLC6A6
R-HSA-5683826	Surfactant metabolism	0.999908563248395	-9.14409321995351e-05	30	3	0.000953591862682772	3146	8202	2627,7270,5029	GATA6,TTF1,P2RY2
R-HSA-114608	Platelet degranulation	0.999909688431635	-9.03156466999453e-05	81	16	0.00508582326764145	3146	8202	967,9948,5552,813,808,87,7422,7114,5478,7057,10487,1675,226,81,7414,7423	CD63,WDR1,SRGN,CALU,CALM3,ACTN1,VEGFA,TMSB4X,PPIA,THBS1,CAP1,CFD,ALDOA,ACTN4,VCL,VEGFB
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	0.999940837765508	-5.91639846458169e-05	86	17	0.00540368722186904	3146	8202	967,9948,5552,813,808,87,6810,7422,7114,5478,7057,10487,1675,226,81,7414,7423	CD63,WDR1,SRGN,CALU,CALM3,ACTN1,STX4,VEGFA,TMSB4X,PPIA,THBS1,CAP1,CFD,ALDOA,ACTN4,VCL,VEGFB
R-HSA-211981	Xenobiotics	0.99996191984644	-3.80808786278755e-05	21	1	0.000317863954227591	3146	8202	29785	CYP2S1
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	0.99996191984644	-3.80808786278755e-05	21	1	0.000317863954227591	3146	8202	3486	IGFBP3
R-HSA-140837	Intrinsic Pathway of Fibrin Clot Formation	0.999976563548432	-2.34367262064043e-05	22	1	0.000317863954227591	3146	8202	2812	GP1BB
R-HSA-166658	Complement cascade	0.999976656120783	-2.33441516893811e-05	38	4	0.00127145581691036	3146	8202	966,715,717,1675	CD59,C1R,C2,CFD
R-HSA-2980736	Peptide hormone metabolism	0.999979566006865	-2.04342019116452e-05	86	16	0.00508582326764145	3146	8202	3799,94027,1499,56605,2626,9314,55676,30001,60412,149371,55770,23265,10640,6934,10159,148867	KIF5B,CGB7,CTNNB1,ERO1B,GATA4,KLF4,SLC30A6,ERO1A,EXOC4,EXOC8,EXOC2,EXOC7,EXOC5,TCF7L2,ATP6AP2,SLC30A7
R-HSA-2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	0.99998557714379	-1.44229602206947e-05	23	1	0.000317863954227591	3146	8202	22949	PTGR1
R-HSA-1474228	Degradation of the extracellular matrix	0.999991854400983	-8.14563219208524e-06	89	16	0.00508582326764145	3146	8202	836,6868,7092,3915,102,5045,682,826,1303,4324,84570,8751,85007,23385,823,7093	CASP3,ADAM17,TLL1,LAMC1,ADAM10,FURIN,BSG,CAPNS1,COL12A1,MMP15,COL25A1,ADAM15,PHYKPL,NCSTN,CAPN1,TLL2
R-HSA-216083	Integrin cell surface interactions	0.999993908544571	-6.09147398192684e-06	67	10	0.00317863954227591	3146	8202	3673,961,3688,682,3678,50848,3685,3693,1605,7057	ITGA2,CD47,ITGB1,BSG,ITGA5,F11R,ITGAV,ITGB5,DAG1,THBS1
R-HSA-1592389	Activation of Matrix Metalloproteinases	0.99999396253266	-6.03748556592539e-06	31	2	0.000635727908455181	3146	8202	4324,5045	MMP15,FURIN
R-HSA-5669034	TNFs bind their physiological receptors	0.999994539039087	-5.46097582383493e-06	25	1	0.000317863954227591	3146	8202	970	CD70
R-HSA-975634	Retinoid metabolism and transport	0.999995519494377	-4.48051566066594e-06	42	4	0.00127145581691036	3146	8202	221914,6382,4035,51109	GPC2,SDC1,LRP1,RDH11
R-HSA-3000178	ECM proteoglycans	0.999996290638877	-3.70936800267236e-06	56	7	0.00222504767959313	3146	8202	3913,3685,3915,3693,1605,3673,3688	LAMB2,ITGAV,LAMC1,ITGB5,DAG1,ITGA2,ITGB1
R-HSA-1474165	Reproduction	0.999996640091477	-3.35991416778518e-06	26	1	0.000317863954227591	3146	8202	7784	ZP3
R-HSA-975298	Ligand-gated ion channel transport	0.999996640091477	-3.35991416778518e-06	26	1	0.000317863954227591	3146	8202	23229	ARHGEF9
R-HSA-1187000	Fertilization	0.999996640091477	-3.35991416778518e-06	26	1	0.000317863954227591	3146	8202	7784	ZP3
R-HSA-5173105	O-linked glycosylation	0.999996779053399	-3.22095178822439e-06	103	19	0.00603941513032422	3146	8202	10678,6480,170689,29071,63917,256435,51809,54507,10610,6487,7057,84752,56913,6484,8693,55568,146712,6482,374378	B3GNT2,ST6GAL1,ADAMTS15,C1GALT1C1,GALNT11,ST6GALNAC3,GALNT7,ADAMTSL4,ST6GALNAC2,ST3GAL3,THBS1,B3GNT9,C1GALT1,ST3GAL4,GALNT4,GALNT10,B3GNTL1,ST3GAL1,GALNT18
R-HSA-420499	Class C/3 (Metabotropic glutamate/pheromone receptors)	0.999998087823318	-1.91217851019794e-06	39	3	0.000953591862682772	3146	8202	2918,2550,83756	GRM8,GABBR1,TAS1R3
R-HSA-5173214	O-glycosylation of TSR domain-containing proteins	0.999998087823318	-1.91217851019794e-06	39	3	0.000953591862682772	3146	8202	54507,170689,7057	ADAMTSL4,ADAMTS15,THBS1
R-HSA-211945	Phase 1 - Functionalization of compounds	0.99999928958986	-7.10410392404434e-07	89	14	0.00445009535918627	3146	8202	1591,128,112812,10858,29785,2232,6256,6916,113612,51302,2230,1592,2052,1545	CYP24A1,ADH5,FDX1L,CYP46A1,CYP2S1,FDXR,RXRA,TBXAS1,CYP2U1,CYP39A1,FDX1,CYP26A1,EPHX1,CYP1B1
R-HSA-375280	Amine ligand-binding receptors	0.999999486879456	-5.13120675555496e-07	42	3	0.000953591862682772	3146	8202	154,151,3269	ADRB2,ADRA2B,HRH1
R-HSA-1296072	Voltage gated Potassium channels	0.999999669833507	-3.30166547647374e-07	43	3	0.000953591862682772	3146	8202	170850,3750,3755	KCNG3,KCND1,KCNG1
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	0.999999846313915	-1.53686096844345e-07	39	2	0.000635727908455181	3146	8202	2812,2152	GP1BB,F3
R-HSA-2187338	Visual phototransduction	0.999999967683357	-3.23166435351724e-08	98	14	0.00445009535918627	3146	8202	4836,2339,221914,10681,23173,4035,2782,808,9249,6382,222236,611,9397,51109	NMT1,FNTA,GPC2,GNB5,METAP1,LRP1,GNB1,CALM3,DHRS3,SDC1,NAPEPLD,OPN1SW,NMT2,RDH11
R-HSA-418555	G alpha (s) signalling events	0.999999982013063	-1.79869375172286e-08	127	21	0.0066751430387794	3146	8202	5141,2785,5734,2782,154,27115,2773,2783,133,5139,50940,2770,2778,10681,2781,4157,59345,115,5150,5144,2771	PDE4A,GNG3,PTGER4,GNB1,ADRB2,PDE7B,GNAI3,GNB2,ADM,PDE3A,PDE11A,GNAI1,GNAS,GNB5,GNAZ,MC1R,GNB4,ADCY9,PDE7A,PDE4D,GNAI2
R-HSA-380108	Chemokine receptors bind chemokines	0.99999998857103	-1.14289704255835e-08	56	4	0.00127145581691036	3146	8202	58191,7852,2920,2921	CXCL16,CXCR4,CXCL2,CXCL3
R-HSA-382551	Transmembrane transport of small molecules	0.999999989280861	-1.07191390288398e-08	586	163	0.0518118245390973	3146	8202	11046,23511,118,1831,10396,89845,55283,537,9197,2782,23456,2030,80024,51076,148867,1186,8504,5002,23446,6717,7220,154091,9972,1836,529,5567,81929,6520,7311,6559,81539,3177,55343,152519,26503,6541,6233,23443,59345,527,3767,861,150159,23315,8992,10723,9429,6522,6505,80727,23165,129401,10347,1317,65125,9311,23657,55676,6548,23545,10999,51606,6558,9114,79902,2512,51248,206358,148229,2778,28231,6533,8671,11182,6566,23636,121260,123606,26133,538,6517,523,2785,29988,5894,9123,2495,347734,348995,5566,2783,27173,23200,6337,488,115,1185,57122,57719,57578,9550,6584,1182,57130,28962,64116,535,4891,360,9631,481,8021,57205,5903,476,10312,10479,6575,9497,482,55129,6526,8480,254428,9990,8766,7037,9057,9883,120,6509,10681,1468,57153,6446,215,11059,7314,3101,53373,5824,57185,27032,92579,7316,7175,51382,1968,22841,2281,1965,55356,3098,7779,6510,528,124935,6583,23229,79901,117247,493,8501	SLC35D2,NUP188,ADD1,TSC22D3,ATP8A1,ABCC10,MCOLN3,ATP6AP1,SLC33A1,GNB1,ABCB10,SLC29A1,SLC8B1,CUTC,SLC30A7,CLCN7,PEX3,SLC22A18,SLC44A1,SRI,TRPC1,SLC2A12,NUP153,SLC26A2,ATP6V1E1,PRKACB,SEH1L,SLC3A2,UBA52,SLC12A3,SLC38A1,SLC29A2,SLC35C1,NIPAL1,SLC17A5,SLC7A1,RPS27A,SLC35A3,GNB4,ATP6V0C,KCNJ11,RUNX1,SLC9B1,SLC9A8,ATP6V0E1,SLC12A7,ABCG2,SLC4A2,SLC1A1,TTYH3,NUP205,NUP35,ABCA7,SLC31A1,WNK1,ASIC3,SLC7A11,SLC30A6,SLC9A1,ATP6V0A2,SLC27A4,ATP6V1H,SLC12A2,ATP6V0D1,NUP85,FTL,PDZD11,SLC36A1,ATP8B3,GNAS,SLCO4A1,SLC6A6,SLC4A4,SLC2A6,SLC16A1,NUP62,SLC15A4,NIPA1,TRPC4AP,ATP7A,SLC2A4,ATP6V1A,GNG3,SLC2A8,RAF1,SLC16A3,FTH1,SLC35B2,NUP43,PRKACA,GNB2,SLC39A1,ATP11B,SCNN1A,ATP2A2,ADCY9,CLCN6,NUP107,ANO8,UNC79,ATP6V1G1,SLC22A5,CLCN3,ATP13A1,OSTM1,SLC39A8,ATP6V0A1,SLC11A2,AQP3,NUP155,ATP1B1,NUP214,ATP10D,RANBP2,ATP1A1,TCIRG1,SLC9A6,SLC20A2,SLC4A7,ATP1B2,ANO10,SLC5A3,RAE1,SLC41A1,SLC12A6,RAB11A,TFRC,SLC7A6,POM121,ADD3,SLC1A4,GNB5,SLC25A10,SLC44A2,SGK1,ABCD1,WWP1,UBB,HK3,TPCN1,PEX19,NIPAL3,ATP2C1,G6PC3,UBC,TPR,ATP6V1D,EIF2S3,RAB11FIP2,FKBP1B,EIF2S1,SLC22A15,HK1,SLC30A1,SLC1A5,ATP6V1C1,SLC43A2,SLC22A4,ARHGEF9,CYBRD1,SLC16A10,ATP2B4,SLC43A1
R-HSA-211859	Biological oxidations	0.999999990031826	-9.9681741327299e-09	194	39	0.012396694214876	3146	8202	1591,7360,10858,7358,6256,2952,347734,4258,51302,2230,1592,2937,4552,128,373156,29785,2232,9061,1836,2098,8574,2052,1545,2954,26873,2729,2948,4259,6916,4144,4257,10327,79017,119391,112812,9,113612,55748,7172	CYP24A1,UGP2,CYP46A1,UGDH,RXRA,GSTT1,SLC35B2,MGST2,CYP39A1,FDX1,CYP26A1,GSS,MTRR,ADH5,GSTK1,CYP2S1,FDXR,PAPSS1,SLC26A2,ESD,AKR7A2,EPHX1,CYP1B1,GSTZ1,OPLAH,GCLC,GSTM4,MGST3,TBXAS1,MAT2A,MGST1,AKR1A1,GGCT,GSTO2,FDX1L,NAT1,CYP2U1,CNDP2,TPMT
R-HSA-112316	Neuronal System	0.999999998311674	-1.68832650169539e-09	289	65	0.0206611570247934	3146	8202	11094,10142,2785,84254,5894,2782,785,5566,2783,2752,9463,4193,6196,1138,115,1739,163,1741,5567,81539,1742,2773,2770,10052,2744,817,170850,3775,59345,3755,3767,784,5594,1175,1173,80331,673,2550,814,808,8500,6505,24145,59283,10681,783,4646,2771,2571,5170,8573,6237,3759,8497,6616,55327,6857,3750,160,3782,3265,23229,781,9424,6197	CACFD1,AKAP9,GNG3,CAMKK1,RAF1,GNB1,CACNB4,PRKACA,GNB2,GLUL,PICK1,MDM2,RPS6KA2,CHRNA5,ADCY9,DLG1,AP2B1,DLG3,PRKACB,SLC38A1,DLG4,GNAI3,GNAI1,GJC1,GLS,CAMK2D,KCNG3,KCNK1,GNB4,KCNG1,KCNJ11,CACNB3,MAPK1,AP2S1,AP2M1,DNAJC5,BRAF,GABBR1,CAMK4,CALM3,PPFIA1,SLC1A1,PANX1,CACNG8,GNB5,CACNB2,MYO6,GNAI2,GAD1,PDPK1,CASK,RRAS,KCNJ2,PPFIA4,SNAP25,LIN7C,SYT1,KCND1,AP2A1,KCNN3,HRAS,ARHGEF9,CACNA2D1,KCNK6,RPS6KA3
R-HSA-1296071	Potassium Channels	0.99999999889473	-1.10526986639542e-09	99	12	0.00381436745073109	3146	8202	170850,3750,3759,3775,2785,2550,3755,3782,2782,3767,2783,9424	KCNG3,KCND1,KCNJ2,KCNK1,GNG3,GABBR1,KCNG1,KCNN3,GNB1,KCNJ11,GNB2,KCNK6
R-HSA-162582	Signal Transduction	0.99999999982333	-1.76670118039109e-10	2357	724	0.230133502860776	3146	8202	23092,7249,71,54903,26160,8350,1488,6777,57406,4628,23566,79003,23493,1387,6869,57665,8379,1785,5499,10097,55233,64223,9736,7311,4035,8550,8743,9113,8239,5335,4087,1398,5719,25936,6233,3984,4296,3065,2932,527,7029,4086,90627,2549,4836,5689,389,6662,7204,30849,7082,84133,90780,5715,83464,2622,8878,57522,5598,114793,79902,7423,23191,7867,58513,81858,5702,5685,2767,388,7504,51109,10273,8202,2339,1845,160,3708,8481,10109,54820,79658,6197,51083,5599,2033,391,685,200734,26052,5607,3955,2785,523,5048,10096,8601,324,1375,348995,5566,25909,488,57122,10213,835,4637,30851,253260,2118,5970,57514,89839,9550,8321,2931,8322,57120,1871,535,6232,7481,10014,2260,8660,3796,5529,7514,51009,558,4085,25937,10272,5590,6198,5536,10672,23112,1844,1173,7186,8325,5929,9491,10542,121504,56998,57449,22938,5708,58191,55920,50999,117145,9138,11059,392,7314,2242,10726,5694,6709,51421,5170,7128,80728,5295,9101,10399,54492,5710,220134,7316,57761,81930,5597,6776,2863,3685,57082,7533,10398,92335,6256,51701,8358,50848,3709,1026,10144,10013,6382,329,6196,1499,5034,3572,5296,5701,51517,1977,151,147179,8331,10616,51107,9978,5571,64105,7422,983,27005,6009,5898,1981,23173,1874,59345,1500,5533,60,8650,64857,58528,9958,5693,5245,5713,8649,3831,1111,10256,5532,5870,3337,83933,9249,5217,57534,5062,4040,51606,9794,5686,3985,8968,7090,8841,84033,23513,5165,10552,8439,2918,9397,6934,10458,5704,6257,23421,389541,2069,4660,94134,286205,4649,1487,81847,2810,10142,91614,5604,64121,2064,8527,4067,23028,5364,1592,5164,4193,182,5687,55845,2781,3551,10768,11171,1856,55114,6655,256933,81565,348235,207,330,991,5734,5727,10971,23401,1857,11214,6487,4088,5903,1907,7185,26090,56957,5709,8326,8338,3020,4343,1175,4089,23385,9170,659,257397,54821,79109,5716,1452,5501,9559,8828,5586,151246,3726,8724,653604,699,3320,79019,1843,7091,3280,387,51098,5692,4303,5905,23365,8357,9564,401541,22943,5467,3012,7852,51382,221914,4987,3516,57636,23229,3015,317749,55366,102,5565,10524,2782,8454,4090,5720,7531,5881,5519,8365,57521,6484,9183,22873,63916,8366,23288,10193,5688,6194,54778,163,5494,611,10818,81929,5160,208,1454,23526,842,9212,60485,2773,2770,25805,25970,3688,83756,10325,5527,4254,8829,409,3066,2245,55081,7375,3728,2550,5562,7410,4983,2619,7057,5581,10092,51564,23596,23545,10018,2771,9475,5915,139285,8437,5908,154,6016,5605,5691,5921,50940,51422,57498,29941,3091,7060,2886,57728,5534,171177,116985,9611,3619,8354,161742,154810,9462,5894,8826,10928,5037,5879,1147,2783,5139,9372,1399,6464,9110,57680,5899,51377,8364,55072,115,1027,5144,841,7321,9828,53637,5163,123169,8452,1742,25776,26108,27115,3710,7297,8324,79682,7532,817,905,2534,9759,79980,27018,55764,10046,3014,5500,657,5711,10252,6396,673,50650,57142,9252,2309,23509,9793,25,728635,2737,10681,896,5781,9055,79659,2065,4091,10253,7050,55789,11130,2648,6654,10276,7976,5045,7525,5747,55288,6249,2768,8334,10023,3569,7027,5150,6259,2852,7855,84292,51699,6789,142678,836,261734,8936,4763,5786,537,11004,2535,81624,30011,84894,5906,5696,9241,5664,9070,2017,529,9754,6453,5567,8352,1058,4690,10287,83737,10413,283455,857,6659,80319,4192,1535,8567,1213,2185,5690,9411,6093,5705,5700,8992,5528,5125,7323,64411,4659,9886,64840,1495,2921,5900,29924,808,814,4205,5997,1847,6788,4952,1291,5584,9735,339745,9114,90268,339403,5029,10152,23433,5141,23286,84447,989,8368,9580,2778,3643,23645,55733,11127,7534,6907,85455,5916,192669,10163,54567,57405,2475,5683,58504,1875,6597,8658,7474,8651,8555,4157,6711,8620,23198,8503,92,7414,10126,55534,2241,5914,79412,5777,5695,55914,1846,995,8050,133,9021,8294,10312,5706,23118,6778,1978,8976,80824,8351,7289,6001,396,6722,23122,9861,151648,5594,57154,10454,1030,56983,8367,11113,89953,8887,8877,2920,10093,8360,84144,3799,466,283149,9181,3717,5717,55166,8345,6774,6199,6667,6868,7480,1024,3164,64750,4221,222236,1729,5595,2885,51592,115557,221955,84078,23220,147841,152559,528,8556,3265,3269	ARHGAP26,TSC2,ACTG1,MKS1,IFT172,HIST1H3A,CTBP2,STAT5B,ABHD6,MYH10,LPAR3,MIS12,HEY2,CREBBP,TACR1,RDH14,MAD1L1,DNM2,PPP1CA,ACTR2,MOB1A,MLST8,USP34,UBA52,LRP1,MAPKAPK5,TNFSF10,LATS1,USP9X,PLCG1,SMAD2,CRK,PSMD13,NSL1,RPS27A,LIMK1,MAP3K11,HDAC1,GSK3B,ATP6V0C,TFDP2,SMAD1,STARD13,GAB1,NMT1,PSMB1,RHOC,SOX9,TRIO,PIK3R4,TJP1,ZNRF3,PYGO2,PSMD9,APH1B,GAS8,SQSTM1,SRGAP1,MAPK7,FMNL2,NUP85,VEGFB,CYFIP1,MAPKAPK3,EPS15L1,SHARPIN,PSMC3,PSMA4,GNA11,RHOB,XK,RDH11,STUB1,NCOA3,FNTA,DUSP3,AP2A1,ITPR1,OFD1,ARPC2,NDE1,ARHGAP10,RPS6KA3,GAL,MAPK8,EP300,RHOG,BTC,SPRED2,DNM3,MAP2K5,LFNG,GNG3,ATP6V1A,PAFAH1B1,ACTR3,RGS20,APC,CPT1B,NUP43,PRKACA,AHCTF1,ATP2A2,NUP107,PSMD14,CASP2,MYL6,TAX1BP3,RICTOR,ETV4,RELA,ARHGAP31,ARHGAP11B,ATP6V1G1,FZD1,GSK3A,FZD4,GOPC,E2F3,ATP6V0A1,RPS27,WNT11,HDAC5,FGFR1,IRS2,KIF2A,PPP2R5E,XPO1,DERL2,AXL,MAD2L1,WWTR1,FSTL3,PRKCZ,RPS6KB1,PPP5C,GNA13,TNRC6B,DUSP2,AP2M1,TRAF2,FZD8,RBBP5,PSMF1,LAMTOR5,HIST4H4,CTNNBIP1,PLEKHG5,SNW1,PSMD2,CXCL16,RCC2,TMED5,THEM4,ARHGEF1,WWP1,ARHGAP1,UBB,FES,NUDC,PSMB6,SPTAN1,AMOTL2,PDPK1,TNFAIP3,ARHGAP39,PIK3R1,USP8,GNB2L1,NEURL1B,PSMD4,SKA1,UBC,TRIB3,KIF18A,MAPK6,STAT5A,GPR39,ITGAV,CASC5,YWHAH,MYL9,STRADA,RXRA,NLK,HIST1H3B,F11R,ITPR2,CDKN1A,FAM13A,HDAC6,SDC1,BIRC2,RPS6KA2,CTNNB1,P4HB,IL6ST,PIK3R2,PSMC2,NCKIPSD,EIF4E,ADRA2B,WIPF2,HIST1H2AJ,RBCK1,APH1A,RBX1,PRKAG1,CENPK,VEGFA,CDK1,USP21,RHEB,RALA,EIF4G1,METAP1,E2F4,GNB4,CTNND1,PPP3CC,ACTB,NUMB,PLEKHG2,RRAGD,USP15,PSMB5,PHB,PSMD7,LAMTOR3,KLC1,CHEK1,CNKSR1,PPP3CB,RAB6A,DNAJB1,HDAC10,DHRS3,PFN2,MIB1,PAK2,LRP6,ATP6V1H,MAML1,PSMA5,LIMK2,HIST1H3F,TLE3,HDAC3,OBSCN,SCRIB,PDK3,ARPC1A,NSMAF,GRM8,NMT2,TCF7L2,BAIAP2,PSMC4,RXRB,ITGB3BP,LAMTOR4,EREG,PPP1R12B,ARHGAP12,SCAI,MYO9A,CTBP1,RNF146,SFN,AKAP9,DEPDC7,MAP2K1,RRAGC,ERBB2,DGKD,LYN,KDM1A,PLXNB1,CYP26A1,PDK2,MDM2,JAG1,PSMA6,BRK1,GNAZ,IKBKB,AHCYL1,STRAP,DVL2,ARHGAP17,SOS2,NPB,NDEL1,SKA2,AKT1,BIRC3,CDC20,PTGER4,PTCH1,YWHAQ,FRAT2,DVL3,AKAP13,ST3GAL3,SMAD3,RANBP2,EDN2,TRAF1,ABHD12,OTUD7B,PSMD3,FZD9,HIST2H2AC,H3F3A,MOV10,AP2S1,SMAD4,NCSTN,LPAR2,BMPR2,TAB3,ERCC6L,MAPKAP1,PSMD10,CSNK1A1,PPP1CC,VPS26A,NRP2,PKN2,SGOL2,JUNB,SNX3,HIST2H3D,BUB1,HSP90AA1,CENPM,DUSP1,TLE4,HES1,RHOA,IFT52,PSMB4,FOXO4,RANGAP1,ARHGEF12,HIST1H3H,BCAR1,CENPP,DKK1,PPARD,HIST1H2AE,CXCR4,ATP6V1D,GPC2,OPRL1,RBPJ,ARHGAP23,ARHGEF9,H2AFZ,DHRS4L2,LGR4,ADAM10,PRKAB2,KAT5,GNB1,CUL1,SMAD5,PSME1,YWHAE,RAC3,PPP2R1B,HIST1H4H,RPTOR,ST3GAL4,ZW10,DZIP1,ELMO2,HIST1H4B,IQCE,RNF41,PSMA7,RPS6,RNF111,AP2B1,PPM1A,OPN1SW,FRS2,SEH1L,PDHA1,AKT2,CSNK1E,HMHA1,CASP9,AURKB,SAV1,GNAI3,GNAI1,BAMBI,SH2B1,ITGB1,TAS1R3,RRAGB,PPP2R5C,KITLG,NRP1,ARRB2,HDAC2,FGD1,IFT57,USP4,JUP,GABBR1,PRKAA1,VAV2,OPHN1,GAS1,THBS1,PRKCE,ARPC5,HDAC7,OPN3,ATP6V0A2,BCL2L11,GNAI2,ROCK2,RARB,AMER1,RASAL1,RAP1B,ADRB2,RIT1,MAP2K2,PSMB3,RASA1,PDE11A,PRKAG2,KIDINS220,PKN3,HIF1A,THBS4,GRB7,WDR19,PPP3R1,RHOV,ARAP1,NCOR1,INCENP,HIST1H3I,SPRED1,AMOTL1,RASAL2,RAF1,IQGAP1,RALBP1,PEBP1,RAC1,CHUK,GNB2,PDE3A,ZFYVE9,CRKL,SHC1,MTMR4,CHD8,RALB,UCHL5,HIST1H4C,RNF31,ADCY9,CDKN1B,PDE4D,CASP8,UBE2D1,ARHGEF17,S1PR5,PDK1,LEO1,CUL3,DLG4,CBY1,PYGO1,PDE7B,ITPR3,TYK2,FZD7,CENPU,YWHAG,CAMK2D,CCNT2,FYN,HDAC4,DSN1,NGFRAP1,IFT122,MAMLD1,H2AFX,PPP1CB,BMPR1A,PSMD5,SPRY1,SEC13,BRAF,ARHGEF3,RTN4,RPS6KA5,FOXO3,POFUT1,CKAP5,ABL1,DHRS4L1,GLI3,GNB5,CCND3,PTPN11,PRC1,DYNC2H1,ERBB3,SMAD6,SPRY2,TGIF1,DEPDC1B,ZWINT,KAT2A,SOS1,NET1,FZD3,FURIN,YES1,PTK2,RHOT1,CLIP1,GNA12,HIST1H2AC,FRAT1,IL6,TFDP1,PDE7A,RYK,GPER1,FZD5,WDR83,VPS29,STK4,MIB2,CASP3,NPHP4,WASF1,NF1,PTPRA,ATP6AP1,KIF2C,FZD2,DIAPH3,SH3KBP1,LINGO1,RAP1A,PSMB8,NOG,PSEN2,ASH2L,CTTN,ATP6V1E1,STARD8,ITSN1,PRKACB,HIST1H3C,CENPA,NCK1,RGS19,ITCH,YAP1,KSR2,CAV1,SOX4,CXXC4,MDK,CYBA,MADD,CLTC,PTK2B,PSMB2,ARHGAP29,ROCK1,PSMC5,PSMC1,ATP6V0E1,PPP2R5D,PCSK5,UBE2D3,ARAP3,PPP1R12A,RHOBTB1,PORCN,CTNNA1,CXCL3,RALGDS,EPN1,CALM3,CAMK4,MEF2A,RGS2,DUSP5,STK3,OCRL,COL6A1,PRKCI,KNTC1,SPOPL,ATP6V0D1,OTULIN,RXFP4,P2RY2,ABI2,RHOQ,PDE4A,WWC1,SYVN1,SEPT7,HIST1H4L,SOX13,GNAS,INSR,PPP1R15A,HHAT,KIF3A,YWHAZ,TBL1X,DISP2,RARG,AGO3,WASF2,DLL4,SPC25,MTOR,PSMA2,ARHGAP22,E2F5,SMARCA4,TNKS,WNT5A,SOCS1,CDC14B,MC1R,SPTBN1,NPFF,PSME4,PIK3R3,ACVR2A,VCL,DNAL4,MAML3,FER,RARA,KREMEN2,PTPN6,PSMB7,ERBB2IP,DUSP4,CDC25C,PDHX,ADM,SOCS3,HIST1H4I,TCIRG1,PSMC6,TAB2,STAT6,EIF4EBP1,WASL,DUSP16,HIST1H3D,TULP3,RGS10,ARHGDIA,SRF,CLASP2,PSMD6,SGOL1,MAPK1,SMURF1,TAB1,CDKN2B,POGLUT1,HIST1H4E,CIT,KLC4,TAX1BP1,SPHK1,CXCL2,ARPC4,HIST1H4D,SYDE2,KIF5B,ATF1,BCL9L,ARHGEF2,JAK2,PSMD11,CENPQ,HIST1H2BH,STAT3,RPS6KB2,SP1,ADAM17,WNT10B,CDK8,NR4A1,SMURF2,MEN1,NAPEPLD,DIAPH1,MAPK3,GRB2,TRIM33,ARHGEF25,DAGLB,KBTBD7,DTX4,SPC24,PAQR3,ATP6V1C1,CDC14A,HRAS,HRH1
R-HSA-372790	Signaling by GPCR	0.999999999846346	-1.53654268835757e-10	1230	212	0.0673871582962492	3146	8202	4763,5786,2782,5720,3709,2535,57406,23566,5519,5906,6869,5696,6196,5688,5296,5701,5499,151,611,10818,5567,6453,7311,9978,208,10287,283455,2773,2770,5719,6233,59345,4296,83756,4254,5690,5527,5533,6093,5705,409,5700,5528,64857,2245,5689,5693,389,2921,7410,5245,7204,2550,8649,5713,814,808,10256,5532,5997,5715,1847,5581,23596,5598,2771,9475,5686,339403,5029,5141,5702,8437,5908,84033,154,5605,2767,5685,5691,2918,388,7504,5921,5704,50940,2778,3708,5534,2069,6197,391,51083,161742,200734,685,10142,9462,5683,2785,5894,8826,5037,5879,8601,5604,2064,8527,5566,2783,5139,5364,7474,5687,6464,2781,6711,4157,8620,115,23198,10213,8503,5144,10768,9828,7414,8321,256933,6655,53637,207,8322,5734,8452,5695,1742,5727,7481,11214,1846,3710,27115,133,2260,8324,8660,5529,1907,817,2534,26090,5706,5709,80824,8326,6001,5536,9861,10672,5594,5711,1844,9170,673,50650,8325,5716,2920,9491,5708,57449,58191,10681,9138,9181,3717,5717,2065,7314,5694,1843,6709,5170,387,5692,7480,6654,10276,7976,5295,23365,5747,5710,7316,5595,2885,2768,7852,115557,221955,84078,5150,152559,4987,2863,2852,7855,84292,23229,3265,3269	NF1,PTPRA,GNB1,PSME1,ITPR2,FZD2,ABHD6,LPAR3,PPP2R1B,RAP1A,TACR1,PSMB8,RPS6KA2,PSMA7,PIK3R2,PSMC2,PPP1CA,ADRA2B,OPN1SW,FRS2,PRKACB,ITSN1,UBA52,RBX1,AKT2,RGS19,KSR2,GNAI3,GNAI1,PSMD13,RPS27A,GNB4,MAP3K11,TAS1R3,KITLG,PSMB2,PPP2R5C,PPP3CC,ROCK1,PSMC5,ARRB2,PSMC1,PPP2R5D,PLEKHG2,FGD1,PSMB1,PSMB5,RHOC,CXCL3,VAV2,PHB,TRIO,GABBR1,LAMTOR3,PSMD7,CAMK4,CALM3,CNKSR1,PPP3CB,RGS2,PSMD9,DUSP5,PRKCE,OPN3,MAPK7,GNAI2,ROCK2,PSMA5,RXFP4,P2RY2,PDE4A,PSMC3,RASAL1,RAP1B,OBSCN,ADRB2,MAP2K2,GNA11,PSMA4,PSMB3,GRM8,RHOB,XK,RASA1,PSMC4,PDE11A,GNAS,ITPR1,PPP3R1,EREG,RPS6KA3,RHOG,GAL,SPRED1,SPRED2,BTC,AKAP9,RASAL2,PSMA2,GNG3,RAF1,IQGAP1,PEBP1,RAC1,RGS20,MAP2K1,ERBB2,DGKD,PRKACA,GNB2,PDE3A,PLXNB1,WNT5A,PSMA6,SHC1,GNAZ,SPTBN1,MC1R,NPFF,ADCY9,PSME4,PSMD14,PIK3R3,PDE4D,AHCYL1,ARHGEF17,VCL,FZD1,NPB,SOS2,S1PR5,AKT1,FZD4,PTGER4,CUL3,PSMB7,DLG4,PTCH1,WNT11,AKAP13,DUSP4,ITPR3,PDE7B,ADM,FGFR1,FZD7,IRS2,PPP2R5E,EDN2,CAMK2D,FYN,ABHD12,PSMC6,PSMD3,DUSP16,FZD9,RGS10,PPP5C,PSMD6,GNA13,MAPK1,PSMD5,DUSP2,LPAR2,BRAF,ARHGEF3,FZD8,PSMD10,CXCL2,PSMF1,PSMD2,PLEKHG5,CXCL16,GNB5,ARHGEF1,ARHGEF2,JAK2,PSMD11,ERBB3,UBB,PSMB6,DUSP1,SPTAN1,PDPK1,RHOA,PSMB4,WNT10B,SOS1,NET1,FZD3,PIK3R1,ARHGEF12,PTK2,PSMD4,UBC,MAPK3,GRB2,GNA12,CXCR4,ARHGEF25,DAGLB,KBTBD7,PDE7A,PAQR3,OPRL1,GPR39,GPER1,FZD5,WDR83,ARHGEF9,HRAS,HRH1
R-HSA-388396	GPCR downstream signaling	0.999999999853304	-1.46696069807733e-10	928	93	0.0295613477431659	3146	8202	51083,391,2785,5879,8601,2782,8527,3709,57406,2783,23566,5139,5364,6869,6464,2781,4157,8620,5296,115,8503,5144,9828,151,611,6453,6655,256933,53637,207,208,10287,5734,11214,3710,27115,2773,133,2770,1907,26090,59345,6001,6093,10672,64857,2245,9170,50650,2921,389,7204,2550,7410,2920,5997,5581,58191,57449,10681,9138,23596,9181,3717,2771,9475,339403,5029,5170,387,5141,6654,10276,5295,84033,23365,154,2767,2918,388,50940,2885,2778,2768,7852,115557,221955,3708,5150,4987,2852,23229,3269	GAL,RHOG,GNG3,RAC1,RGS20,GNB1,DGKD,ITPR2,ABHD6,GNB2,LPAR3,PDE3A,PLXNB1,TACR1,SHC1,GNAZ,MC1R,NPFF,PIK3R2,ADCY9,PIK3R3,PDE4D,ARHGEF17,ADRA2B,OPN1SW,ITSN1,SOS2,NPB,S1PR5,AKT1,AKT2,RGS19,PTGER4,AKAP13,ITPR3,PDE7B,GNAI3,ADM,GNAI1,EDN2,ABHD12,GNB4,RGS10,ROCK1,GNA13,PLEKHG2,FGD1,LPAR2,ARHGEF3,CXCL3,RHOC,TRIO,GABBR1,VAV2,CXCL2,RGS2,PRKCE,CXCL16,PLEKHG5,GNB5,ARHGEF1,OPN3,ARHGEF2,JAK2,GNAI2,ROCK2,RXFP4,P2RY2,PDPK1,RHOA,PDE4A,SOS1,NET1,PIK3R1,OBSCN,ARHGEF12,ADRB2,GNA11,GRM8,RHOB,PDE11A,GRB2,GNAS,GNA12,CXCR4,ARHGEF25,DAGLB,ITPR1,PDE7A,OPRL1,GPER1,ARHGEF9,HRH1
R-HSA-500792	GPCR ligand binding	0.999999999875386	-1.24614204041394e-10	444	47	0.0149396058486968	3146	8202	51083,9170,2785,2921,8325,2550,2782,2920,2535,2783,23566,7474,58191,6869,10681,4157,8620,23596,151,611,339403,5029,8321,256933,53637,7480,8322,7976,5734,5727,7481,154,133,2918,8324,7504,2778,1907,7852,59345,8326,83756,4987,2863,2852,7855,3269	GAL,LPAR2,GNG3,CXCL3,FZD8,GABBR1,GNB1,CXCL2,FZD2,GNB2,LPAR3,WNT5A,CXCL16,TACR1,GNB5,MC1R,NPFF,OPN3,ADRA2B,OPN1SW,RXFP4,P2RY2,FZD1,NPB,S1PR5,WNT10B,FZD4,FZD3,PTGER4,PTCH1,WNT11,ADRB2,ADM,GRM8,FZD7,XK,GNAS,EDN2,CXCR4,GNB4,FZD9,TAS1R3,OPRL1,GPR39,GPER1,FZD5,HRH1
R-HSA-381753	Olfactory Signaling Pathway	0.999999999889072	-1.10928535566688e-10	381	1	0.000317863954227591	3146	8202	2782	GNB1
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	0.999999999918278	-8.17217855721675e-11	318	25	0.00794659885568976	3146	8202	51083,256933,9170,53637,2921,5734,154,2920,23566,7504,58191,1907,7852,6869,4157,8620,23596,4987,2863,2852,151,611,339403,5029,3269	GAL,NPB,LPAR2,S1PR5,CXCL3,PTGER4,ADRB2,CXCL2,LPAR3,XK,CXCL16,EDN2,CXCR4,TACR1,MC1R,NPFF,OPN3,OPRL1,GPR39,GPER1,ADRA2B,OPN1SW,RXFP4,P2RY2,HRH1
R-HSA-1474244	Extracellular matrix organization	0.999999999921142	-7.88581031765933e-11	267	49	0.0155753337571519	3146	8202	836,5479,7092,102,79709,682,50848,84695,6382,2192,3693,4054,30008,7057,667,5034,84570,1289,1291,8751,3913,85007,10491,4015,6868,8573,3915,10536,5045,3678,826,1294,87,5339,1605,1303,22795,4324,5352,4239,961,3673,3688,3685,8985,1288,23385,823,7093	CASP3,PPIB,TLL1,ADAM10,COLGALT1,BSG,F11R,LOXL3,SDC1,FBLN1,ITGB5,LTBP3,EFEMP2,THBS1,DST,P4HB,COL25A1,COL5A1,COL6A1,ADAM15,LAMB2,PHYKPL,CRTAP,LOX,ADAM17,CASK,LAMC1,P3H3,FURIN,ITGA5,CAPNS1,COL7A1,ACTN1,PLEC,DAG1,COL12A1,NID2,MMP15,PLOD2,MFAP4,CD47,ITGA2,ITGB1,ITGAV,PLOD3,COL4A6,NCSTN,CAPN1,TLL2
R-HSA-418594	G alpha (i) signalling events	0.999999999939226	-6.07740797296581e-11	236	31	0.00985378258105531	3146	8202	51083,256933,9170,53637,2785,2921,10287,2550,8601,2782,2920,2773,2783,23566,2918,2770,2778,58191,7852,10681,2781,59345,115,6001,23596,4987,2852,2771,151,611,339403	GAL,NPB,LPAR2,S1PR5,GNG3,CXCL3,RGS19,GABBR1,RGS20,GNB1,CXCL2,GNAI3,GNB2,LPAR3,GRM8,GNAI1,GNAS,CXCL16,CXCR4,GNB5,GNAZ,GNB4,ADCY9,RGS10,OPN3,OPRL1,GPER1,GNAI2,ADRA2B,OPN1SW,RXFP4
R-HSA-416476	G alpha (q) signalling events	0.999999999945197	-5.48027279361222e-11	190	28	0.00890019071837254	3146	8202	9170,2785,10287,5295,7204,2782,8527,3709,3710,5997,57406,2767,2783,23566,5581,1907,6869,115557,10681,221955,26090,59345,8620,5296,3708,8503,5029,3269	LPAR2,GNG3,RGS19,PIK3R1,TRIO,GNB1,DGKD,ITPR2,ITPR3,RGS2,ABHD6,GNA11,GNB2,LPAR3,PRKCE,EDN2,TACR1,ARHGEF25,GNB5,DAGLB,ABHD12,GNB4,NPFF,PIK3R2,ITPR1,PIK3R3,P2RY2,HRH1
R-HSA-375276	Peptide ligand-binding receptors	0.999999999948897	-5.11028055038165e-11	193	14	0.00445009535918627	3146	8202	51083,1907,58191,256933,7852,6869,2921,4157,8620,4987,2852,2920,7504,339403	GAL,EDN2,CXCL16,NPB,CXCR4,TACR1,CXCL3,MC1R,NPFF,OPRL1,GPER1,CXCL2,XK,RXFP4
R-HSA-916853	Degradation of GABA	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-205017	NFG and proNGF binds to p75NTR	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-168277	Influenza Virus Induced Apoptosis	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-379397	Enzymatic degradation of dopamine by COMT	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-176034	Interactions of Tat with host cellular proteins	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-1299361	TWIK-related alkaline pH activated K+ channel (TALK)	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-177162	Conjugation of phenylacetate with glutamine	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-5579031	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-141334	PAOs oxidise polyamines to amines	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-3828062	Glycogen storage disease type 0 (muscle GYS1)	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-844623	The IPAF inflammasome	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-5638303	Inhibition of Signaling by Overexpressed EGFR	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-380612	Metabolism of serotonin	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-1299316	TWIK-releated acid-sensitive K+ channel (TASK)	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-3642279	TGFBR2 MSI Frameshift Mutants in Cancer	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-190872	Transport of connexons to the plasma membrane	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-5687868	Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-211994	Sterols are 12-hydroxylated by CYP8B1	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-5688354	Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-380615	Serotonin clearance from the synaptic cleft	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-5357609	Glycogen storage disease type II (GAA)	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-379398	Enzymatic degradation of Dopamine by monoamine oxidase	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-187042	TRKA activation by NGF	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-75094	Formation of the Editosome	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-166020	Transfer of LPS from LBP carrier to CD14	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-3814836	Glycogen storage disease type XV (GYG1)	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-141333	Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-168315	Inhibition of Host mRNA Processing and RNA Silencing	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-3359485	Defective CD320 causes methylmalonic aciduria	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-5619107	Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC)	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-451307	Activation of Na-permeable Kainate Receptors	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-3858516	Glycogen storage disease type 0 (liver GYS2)	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-432030	Transport of glycerol from adipocytes to the liver by Aquaporins	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-72200	mRNA Editing: C to U Conversion	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-5638302	Signaling by Overexpressed Wild-Type EGFR in Cancer	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-5662702	Melanin biosynthesis	0.999999999980297	-1.97029892401446e-11	2	0	0	3146	8202
R-HSA-265473	Trafficking of dietary sterols	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-5653890	Lactose synthesis	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-3359463	Defective CUBN causes hereditary megaloblastic anemia 1	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-1483152	Hydrolysis of LPE	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-73843	5-Phosphoribose 1-diphosphate biosynthesis	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-163282	Mitochondrial transcription initiation	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-193681	Ceramide signalling	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-379401	Dopamine clearance from the synaptic cleft	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-5357572	Lysosomal glycogen catabolism	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-190704	Oligomerization of connexins into connexons	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-3359462	Defective AMN causes hereditary megaloblastic anemia 1	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-1299503	TWIK related potassium channel (TREK)	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-1296067	Potassium transport channels	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-2892245	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-977442	GABA A (rho) receptor activation	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-3296197	Hydroxycarboxylic acid-binding receptors	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-217271	FMO oxidises nucleophiles	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-427589	Type II Na+/Pi cotransporters	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-444411	Rhesus glycoproteins mediate ammonium transport.	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-190827	Transport of connexins along the secretory pathway	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-844615	The AIM2 inflammasome	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-1307965	betaKlotho-mediated ligand binding	0.999999999985789	-1.42105979761276e-11	3	0	0	3146	8202
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	0.999999999986588	-1.34120216306831e-11	115	10	0.00317863954227591	3146	8202	79465,5817,4277,100507436,3688,567,958,8519,3105,80329	ULBP3,PVR,MICB,MICA,ITGB1,B2M,CD40,IFITM1,HLA-A,ULBP1
R-HSA-1222499	Response of Mtb to phagocytosis	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-3359454	Defective TCN2 causes hereditary megaloblastic anemia	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-5602410	TLR3 deficiency - HSE	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-190840	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-112122	ALKBH2 mediated reversal of alkylation damage	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-1299344	TWIK-related spinal cord K+ channel (TRESK)	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-1839128	FGFR4 mutant receptor activation	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-2534343	Interaction With Cumulus Cells	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-3248023	Regulation by TREX1	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-1222352	Latent infection of Homo sapiens with Mycobacterium tuberculosis	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-480985	Synthesis of dolichyl-phosphate-glucose	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-1855231	Synthesis of IPs in the ER lumen	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-211957	Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-1299287	Tandem pore domain halothane-inhibited K+ channel (THIK)	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-1483076	Synthesis of CL	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-168275	Entry of Influenza Virion into Host Cell via Endocytosis	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-140180	COX reactions	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-5619058	Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-5678895	Defective CFTR causes cystic fibrosis	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-5619110	Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-5250982	Toxicity of tetanus toxin (TeNT)	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-2023837	Signaling by FGFR2 amplification mutants	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-1222449	Mtb iron assimilation by chelation	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-1300645	Acrosome Reaction	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-3359457	Defective GIF causes intrinsic factor deficiency	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-975574	Reactions specific to the hybrid N-glycan synthesis pathway	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-2142696	Synthesis of Hepoxilins (HX) and Trioxilins (TrX)	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-5619084	ABC transporter disorders	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-1483196	PI and PC transport between ER and Golgi membranes	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-5602415	UNC93B1 deficiency - HSE	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-2033515	t(4;14) translocations of FGFR3	0.999999999989713	-1.02874375684792e-11	1	0	0	3146	8202
R-HSA-3642278	Loss of Function of TGFBR2 in Cancer	1.00000000000129	1.28757074446817e-12	4	0	0	3146	8202
R-HSA-3645790	TGFBR2 Kinase Domain Mutants in Cancer	1.00000000000129	1.28757074446817e-12	4	0	0	3146	8202
R-HSA-1296061	HCN channels	1.00000000000129	1.28757074446817e-12	4	0	0	3146	8202
R-HSA-3656535	TGFBR1 LBD Mutants in Cancer	1.00000000000129	1.28757074446817e-12	4	0	0	3146	8202
R-HSA-888593	Reuptake of GABA	1.00000000000129	1.28757074446817e-12	4	0	0	3146	8202
R-HSA-3000497	Scavenging by Class H Receptors	1.00000000000129	1.28757074446817e-12	4	0	0	3146	8202
R-HSA-399710	Activation of AMPA receptors	1.00000000000129	1.28757074446817e-12	4	0	0	3146	8202
R-HSA-209905	Catecholamine biosynthesis	1.00000000000129	1.28757074446817e-12	4	0	0	3146	8202
R-HSA-417973	Adenosine P1 receptors	1.00000000000129	1.28757074446817e-12	4	0	0	3146	8202
R-HSA-3878781	Glycogen storage disease type IV (GBE1)	1.00000000000129	1.28757074446817e-12	4	0	0	3146	8202
R-HSA-140179	Amine Oxidase reactions	1.00000000000129	1.28757074446817e-12	4	0	0	3146	8202
R-HSA-428776	Class II GLUTs	1.00000000000129	1.28757074446817e-12	4	0	0	3146	8202
R-HSA-5619099	Defective AVP causes neurohypophyseal diabetes insipidus (NDI)	1.00000000000129	1.28757074446817e-12	4	0	0	3146	8202
R-HSA-70921	Histidine catabolism	1.00000000000488	4.88036304077677e-12	6	0	0	3146	8202
R-HSA-388479	Vasopressin-like receptors	1.00000000000488	4.88036304077677e-12	6	0	0	3146	8202
R-HSA-171052	LDL-mediated lipid transport	1.00000000000488	4.88036304077677e-12	6	0	0	3146	8202
R-HSA-193993	Mineralocorticoid biosynthesis	1.00000000000488	4.88036304077677e-12	6	0	0	3146	8202
R-HSA-187015	Activation of TRKA receptors	1.00000000000488	4.88036304077677e-12	6	0	0	3146	8202
R-HSA-177135	Conjugation of benzoate with glycine	1.00000000000488	4.88036304077677e-12	6	0	0	3146	8202
R-HSA-166662	Lectin pathway of complement activation	1.00000000000488	4.88036304077677e-12	6	0	0	3146	8202
R-HSA-390648	Muscarinic acetylcholine receptors	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-2161541	Abacavir metabolism	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-3000471	Scavenging by Class B Receptors	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-1300652	Sperm:Oocyte Membrane Binding	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-444209	Free fatty acid receptors	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-5250981	Toxicity of botulinum toxin type F (BoNT/F)	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-210746	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-390651	Dopamine receptors	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-187024	NGF-independant TRKA activation	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-5250955	Toxicity of botulinum toxin type D (BoNT/D)	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-2855086	Ficolins bind to repetitive carbohydrate structures on the target cell surface	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-561048	Organic anion transport	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-433137	Sodium-coupled sulphate, di- and tri-carboxylate transporters	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-391906	Leukotriene receptors	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-209931	Serotonin and melatonin biosynthesis	1.00000000000651	6.51280938901433e-12	5	0	0	3146	8202
R-HSA-190377	FGFR2b ligand binding and activation	1.0000000000099	9.90041792851056e-12	10	0	0	3146	8202
R-HSA-156587	Amino Acid conjugation	1.00000000001044	1.04382216303649e-11	9	0	0	3146	8202
R-HSA-1300642	Sperm Motility And Taxes	1.00000000001044	1.04382216303649e-11	9	0	0	3146	8202
R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide	1.00000000001044	1.04382216303649e-11	9	0	0	3146	8202
R-HSA-1480926	O2/CO2 exchange in erythrocytes	1.00000000001044	1.04382216303649e-11	9	0	0	3146	8202
R-HSA-189085	Digestion of dietary carbohydrate	1.00000000001044	1.04382216303649e-11	9	0	0	3146	8202
R-HSA-159424	Conjugation of carboxylic acids	1.00000000001044	1.04382216303649e-11	9	0	0	3146	8202
R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen	1.00000000001044	1.04382216303649e-11	9	0	0	3146	8202
R-HSA-1462054	Alpha-defensins	1.00000000001044	1.04382216303649e-11	9	0	0	3146	8202
R-HSA-444473	Formyl peptide receptors bind formyl peptides and many other ligands	1.00000000001164	1.16378125669322e-11	8	0	0	3146	8202
R-HSA-159763	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	1.00000000001164	1.16378125669322e-11	8	0	0	3146	8202
R-HSA-5619115	Disorders of transmembrane transporters	1.00000000001164	1.16378125669322e-11	8	0	0	3146	8202
R-HSA-1483115	Hydrolysis of LPC	1.00000000001164	1.16378125669322e-11	8	0	0	3146	8202
R-HSA-5688849	Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)	1.00000000001164	1.16378125669322e-11	8	0	0	3146	8202
R-HSA-5688890	Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)	1.00000000001164	1.16378125669322e-11	8	0	0	3146	8202
R-HSA-112311	Neurotransmitter Clearance In The Synaptic Cleft	1.00000000001164	1.16378125669322e-11	8	0	0	3146	8202
R-HSA-177128	Conjugation of salicylate with glycine	1.00000000001164	1.16378125669322e-11	8	0	0	3146	8202
R-HSA-210747	Regulation of gene expression in early pancreatic precursor cells	1.00000000001164	1.16378125669322e-11	8	0	0	3146	8202
R-HSA-375281	Hormone ligand-binding receptors	1.00000000001202	1.20219365366792e-11	11	0	0	3146	8202
R-HSA-193048	Androgen biosynthesis	1.00000000001202	1.20219365366792e-11	11	0	0	3146	8202
R-HSA-190322	FGFR4 ligand binding and activation	1.00000000001755	1.75543796587395e-11	14	0	0	3146	8202
R-HSA-447043	Neurofascin interactions	1.00000000001985	1.98513545011936e-11	7	0	0	3146	8202
R-HSA-3656225	Defective CHST6 causes MCDC1	1.00000000001985	1.98513545011936e-11	7	0	0	3146	8202
R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors	1.00000000001985	1.98513545011936e-11	7	0	0	3146	8202
R-HSA-166665	Terminal pathway of complement	1.00000000001985	1.98513545011936e-11	7	0	0	3146	8202
R-HSA-190371	FGFR3b ligand binding and activation	1.00000000001985	1.98513545011936e-11	7	0	0	3146	8202
R-HSA-3656244	Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	1.00000000001985	1.98513545011936e-11	7	0	0	3146	8202
R-HSA-5619102	SLC transporter disorders	1.00000000001985	1.98513545011936e-11	7	0	0	3146	8202
R-HSA-3656243	Defective ST3GAL3 causes MCT12 and EIEE15	1.00000000001985	1.98513545011936e-11	7	0	0	3146	8202
R-HSA-211935	Fatty acids	1.0000000000218	2.17980707127261e-11	15	0	0	3146	8202
R-HSA-190241	FGFR2 ligand binding and activation	1.00000000002497	2.49682137137405e-11	20	0	0	3146	8202
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	1.00000000002638	2.63797999404711e-11	18	0	0	3146	8202
R-HSA-140875	Common Pathway of Fibrin Clot Formation	1.00000000002716	2.71560632186976e-11	22	0	0	3146	8202
R-HSA-1839130	Signaling by activated point mutants of FGFR3	1.00000000003084	3.08366646528267e-11	12	0	0	3146	8202
R-HSA-390666	Serotonin receptors	1.00000000003084	3.08366646528267e-11	12	0	0	3146	8202
R-HSA-190239	FGFR3 ligand binding and activation	1.00000000003084	3.08366646528267e-11	12	0	0	3146	8202
R-HSA-2033514	FGFR3 mutant receptor activation	1.00000000003084	3.08366646528267e-11	12	0	0	3146	8202
R-HSA-190372	FGFR3c ligand binding and activation	1.00000000003084	3.08366646528267e-11	12	0	0	3146	8202
R-HSA-1679131	Trafficking and processing of endosomal TLR	1.00000000003277	3.27746968663788e-11	13	0	0	3146	8202
R-HSA-190375	FGFR2c ligand binding and activation	1.00000000003277	3.27746968663788e-11	13	0	0	3146	8202
R-HSA-1461973	Defensins	1.00000000004021	4.02064427164577e-11	51	0	0	3146	8202
R-HSA-1461957	Beta defensins	1.00000000004068	4.06786743613485e-11	42	0	0	3146	8202
R-HSA-2033519	Activated point mutants of FGFR2	1.0000000000408	4.07952522953321e-11	17	0	0	3146	8202
R-HSA-1839126	FGFR2 mutant receptor activation	1.0000000000408	4.07952522953321e-11	17	0	0	3146	8202
R-HSA-202427	Phosphorylation of CD3 and TCR zeta chains	1.00000000005149	5.14948321642904e-11	21	0	0	3146	8202