TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols SMP00391 Insulin Signalling 0.000449149879177578 -7.70815391929148 11 10 0.0267379679144385 374 978 2885,5170,3643,6517,207,6654,5894,5594,3265,5605 GRB2,PDPK1,INSR,SLC2A4,AKT1,SOS1,RAF1,MAPK1,HRAS,MAP2K2 SMP00603 Gemcitabine Metabolism Pathway 0.00508634758199483 -5.28119527338246 13 10 0.0267379679144385 374 978 4830,50484,1633,6240,6241,7298,30833,1635,2030,51727 NME1,RRM2B,DCK,RRM1,RRM2,TYMS,NT5C,DCTD,SLC29A1,CMPK1 SMP00446 Gemcitabine Action Pathway 0.00508634758199483 -5.28119527338246 13 10 0.0267379679144385 374 978 4830,50484,1633,6240,6241,7298,30833,1635,2030,51727 NME1,RRM2B,DCK,RRM1,RRM2,TYMS,NT5C,DCTD,SLC29A1,CMPK1 SMP00654 Warburg Effect 0.0119073786102455 -4.43059701973589 45 25 0.0668449197860963 374 978 5160,2597,25796,8802,6391,3419,5315,3417,1743,51660,5226,6392,50,5091,5211,2539,1431,6566,8801,4190,5224,6510,3420,6888,22934 PDHA1,GAPDH,PGLS,SUCLG1,SDHC,IDH3A,PKM,IDH1,DLST,MPC1,PGD,SDHD,ACO2,PC,PFKL,G6PD,CS,SLC16A1,SUCLG2,MDH1,PGAM2,SLC1A5,IDH3B,TALDO1,RPIA SMP00466 Transfer of Acetyl Groups into Mitochondria 0.0186882574591003 -3.97985989572422 9 7 0.018716577540107 374 978 5160,8402,4190,4199,5091,51660,1431 PDHA1,SLC25A11,MDH1,ME1,PC,MPC1,CS SMP00129 Malate-Aspartate Shuttle 0.0211743180255269 -3.85496624554935 4 4 0.0106951871657754 374 978 8604,8402,2806,4191 SLC25A12,SLC25A11,GOT2,MDH2 SMP00092 Rosuvastatin Action Pathway 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00508 Cholesteryl ester storage disease 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00510 Mevalonic aciduria 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00387 CHILD Syndrome 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00095 Alendronate Action Pathway 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00107 Zoledronate Action Pathway 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00548 Mitochondrial complex II deficiency 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 5160,50,5091,8802,6391,3419,4191,1431,8801,3420,1743,51660,6392 PDHA1,ACO2,PC,SUCLG1,SDHC,IDH3A,MDH2,CS,SUCLG2,IDH3B,DLST,MPC1,SDHD SMP00389 Smith-Lemli-Opitz Syndrome (SLOS) 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00112 Risedronate Action Pathway 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,3157,39,3422,6307,50814,2224,7108,9453,10654,3156,2222,10682 LSS,HMGCS1,ACAT2,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00119 Fluvastatin Action Pathway 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00079 Ibandronate Action Pathway 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00057 Citric Acid Cycle 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 5160,50,5091,8802,6391,3419,4191,1431,8801,3420,1743,51660,6392 PDHA1,ACO2,PC,SUCLG1,SDHC,IDH3A,MDH2,CS,SUCLG2,IDH3B,DLST,MPC1,SDHD SMP00209 Hypercholesterolemia 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00388 Chondrodysplasia Punctata II- X Linked Dominant (CDPX2) 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00386 Desmosterolosis 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00551 Pyruvate dehydrogenase deficiency (E2) 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 5160,50,5091,8802,6391,3419,4191,1431,8801,3420,1743,51660,6392 PDHA1,ACO2,PC,SUCLG1,SDHC,IDH3A,MDH2,CS,SUCLG2,IDH3B,DLST,MPC1,SDHD SMP00511 Wolman disease 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00023 Steroid Biosynthesis 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00099 Lovastatin Action Pathway 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00509 Hyper-IgD syndrome 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,3156,2222,10682 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00131 Atorvastatin Action Pathway 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00082 Simvastatin Action Pathway 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,3157,39,3422,6307,50814,2224,7108,9453,10654,3156,2222,10682 LSS,HMGCS1,ACAT2,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,HMGCR,FDFT1,EBP SMP00117 Pamidronate Action Pathway 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00546 Congenital lactic acidosis 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 5160,50,5091,8802,6391,3419,4191,1431,8801,3420,1743,51660,6392 PDHA1,ACO2,PC,SUCLG1,SDHC,IDH3A,MDH2,CS,SUCLG2,IDH3B,DLST,MPC1,SDHD SMP00319 Lysosomal Acid Lipase Deficiency (Wolman Disease) 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00111 Cerivastatin Action Pathway 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00549 2-ketoglutarate dehydrogenase complex deficiency 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 5160,50,5091,8802,6391,3419,4191,1431,8801,3420,1743,51660,6392 PDHA1,ACO2,PC,SUCLG1,SDHC,IDH3A,MDH2,CS,SUCLG2,IDH3B,DLST,MPC1,SDHD SMP00547 Fumarase deficiency 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 5160,50,5091,8802,6391,3419,4191,1431,8801,3420,1743,51660,6392 PDHA1,ACO2,PC,SUCLG1,SDHC,IDH3A,MDH2,CS,SUCLG2,IDH3B,DLST,MPC1,SDHD SMP00089 Pravastatin Action Pathway 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 4047,39,3157,3422,6307,50814,2224,7108,9453,10654,10682,2222,3156 LSS,ACAT2,HMGCS1,IDI1,MSMO1,NSDHL,FDPS,TM7SF2,GGPS1,PMVK,EBP,FDFT1,HMGCR SMP00550 Pyruvate dehydrogenase deficiency (E3) 0.0227046091321651 -3.78518732963589 21 13 0.0347593582887701 374 978 5160,50,5091,8802,6391,3419,4191,1431,8801,3420,1743,51660,6392 PDHA1,ACO2,PC,SUCLG1,SDHC,IDH3A,MDH2,CS,SUCLG2,IDH3B,DLST,MPC1,SDHD SMP00355 Mitochondrial Electron Transport Chain 0.0232650101959268 -3.76080475543388 19 12 0.0320855614973262 374 978 2597,291,6391,509,4694,7384,498,506,514,2819,515,6392 GAPDH,SLC25A4,SDHC,ATP5C1,NDUFA1,UQCRC1,ATP5A1,ATP5B,ATP5E,GPD1,ATP5F1,SDHD SMP00518 Glucose-6-phosphate dehydrogenase deficiency 0.0234594270274022 -3.75248285943945 15 10 0.0267379679144385 374 978 5236,25796,5211,2539,226,64080,6120,6888,5226,22934 PGM1,PGLS,PFKL,G6PD,ALDOA,RBKS,RPE,TALDO1,PGD,RPIA SMP00031 Pentose Phosphate Pathway 0.0234594270274022 -3.75248285943945 15 10 0.0267379679144385 374 978 5236,25796,5211,2539,226,64080,6120,6888,5226,22934 PGM1,PGLS,PFKL,G6PD,ALDOA,RBKS,RPE,TALDO1,PGD,RPIA SMP00519 Ribose-5-phosphate isomerase deficiency 0.0234594270274022 -3.75248285943945 15 10 0.0267379679144385 374 978 5236,25796,5211,2539,226,64080,6120,6888,5226,22934 PGM1,PGLS,PFKL,G6PD,ALDOA,RBKS,RPE,TALDO1,PGD,RPIA SMP00520 Transaldolase deficiency 0.0234594270274022 -3.75248285943945 15 10 0.0267379679144385 374 978 5236,25796,5211,2539,226,64080,6120,6888,5226,22934 PGM1,PGLS,PFKL,G6PD,ALDOA,RBKS,RPE,TALDO1,PGD,RPIA SMP00428 Mercaptopurine Action Pathway 0.0459586958497208 -3.08001220217179 47 24 0.0641711229946524 374 978 10201,4860,5471,3704,84896,3177,5879,6240,158,6241,353,2030,318,3251,203,957,10606,471,3614,8833,11164,5144,132,7172 NME6,PNP,PPAT,ITPA,ATAD1,SLC29A2,RAC1,RRM1,ADSL,RRM2,APRT,SLC29A1,NUDT2,HPRT1,AK1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,NUDT5,PDE4D,ADK,TPMT SMP00430 Thioguanine Action Pathway 0.0459586958497208 -3.08001220217179 47 24 0.0641711229946524 374 978 10201,4860,3704,5471,3177,84896,5879,6240,6241,158,353,2030,318,203,3251,957,10606,471,3614,8833,11164,5144,132,7172 NME6,PNP,ITPA,PPAT,SLC29A2,ATAD1,RAC1,RRM1,RRM2,ADSL,APRT,SLC29A1,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,NUDT5,PDE4D,ADK,TPMT SMP00427 Azathioprine Action Pathway 0.0459586958497208 -3.08001220217179 47 24 0.0641711229946524 374 978 10201,4860,3704,5471,3177,84896,5879,6240,6241,158,353,2030,318,203,3251,957,10606,471,3614,8833,11164,5144,132,7172 NME6,PNP,ITPA,PPAT,SLC29A2,ATAD1,RAC1,RRM1,RRM2,ADSL,APRT,SLC29A1,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,NUDT5,PDE4D,ADK,TPMT SMP00219 UMP Synthase Deiciency (Orotic Aciduria) 0.0556498799578269 -2.88867535835497 23 13 0.0347593582887701 374 978 1890,10201,50484,3704,54963,1854,1723,6241,124583,7298,1635,50808,1806 TYMP,NME6,RRM2B,ITPA,UCKL1,DUT,DHODH,RRM2,CANT1,TYMS,DCTD,AK3,DPYD SMP00202 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) 0.0556498799578269 -2.88867535835497 23 13 0.0347593582887701 374 978 1890,10201,50484,3704,54963,1854,1723,6241,124583,7298,1635,50808,1806 TYMP,NME6,RRM2B,ITPA,UCKL1,DUT,DHODH,RRM2,CANT1,TYMS,DCTD,AK3,DPYD SMP00172 Beta Ureidopropionase Deficiency 0.0556498799578269 -2.88867535835497 23 13 0.0347593582887701 374 978 1890,10201,50484,3704,54963,1854,7298,124583,6241,1723,1635,1806,50808 TYMP,NME6,RRM2B,ITPA,UCKL1,DUT,TYMS,CANT1,RRM2,DHODH,DCTD,DPYD,AK3 SMP00046 Pyrimidine Metabolism 0.0556498799578269 -2.88867535835497 23 13 0.0347593582887701 374 978 1890,10201,50484,3704,54963,1854,1723,6241,124583,7298,1635,50808,1806 TYMP,NME6,RRM2B,ITPA,UCKL1,DUT,DHODH,RRM2,CANT1,TYMS,DCTD,AK3,DPYD SMP00178 Dihydropyrimidinase Deficiency 0.0556498799578269 -2.88867535835497 23 13 0.0347593582887701 374 978 1890,10201,50484,3704,54963,1854,7298,124583,6241,1723,1635,1806,50808 TYMP,NME6,RRM2B,ITPA,UCKL1,DUT,TYMS,CANT1,RRM2,DHODH,DCTD,DPYD,AK3 SMP00358 Fc Epsilon Receptor I Signaling in Mast Cells 0.0590388809771597 -2.82955905250844 32 17 0.0454545454545455 374 978 5599,5163,207,5609,6654,5894,5295,5879,5605,5606,2885,5335,2534,5608,5594,6416,3265 MAPK8,PDK1,AKT1,MAP2K7,SOS1,RAF1,PIK3R1,RAC1,MAP2K2,MAP2K3,GRB2,PLCG1,FYN,MAP2K6,MAPK1,MAP2K4,HRAS SMP00203 Molybdenum Cofactor Deficiency 0.0682043572230245 -2.68524682727288 37 19 0.0508021390374332 374 978 10201,4860,5471,3704,84896,6240,6241,158,353,318,203,3251,957,10606,471,3614,8833,5144,11164 NME6,PNP,PPAT,ITPA,ATAD1,RRM1,RRM2,ADSL,APRT,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,PDE4D,NUDT5 SMP00167 Adenylosuccinate Lyase Deficiency 0.0682043572230245 -2.68524682727288 37 19 0.0508021390374332 374 978 10201,4860,5471,3704,84896,6240,6241,158,353,318,203,3251,957,10606,471,3614,8833,5144,11164 NME6,PNP,PPAT,ITPA,ATAD1,RRM1,RRM2,ADSL,APRT,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,PDE4D,NUDT5 SMP00365 Gout or Kelley-Seegmiller Syndrome 0.0682043572230245 -2.68524682727288 37 19 0.0508021390374332 374 978 10201,4860,5471,3704,84896,6240,6241,158,353,318,203,3251,957,10606,471,3614,8833,5144,11164 NME6,PNP,PPAT,ITPA,ATAD1,RRM1,RRM2,ADSL,APRT,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,PDE4D,NUDT5 SMP00220 Xanthine Dehydrogenase Deficiency (Xanthinuria) 0.0682043572230245 -2.68524682727288 37 19 0.0508021390374332 374 978 10201,4860,5471,3704,84896,6240,6241,158,353,318,203,3251,957,10606,471,3614,8833,5144,11164 NME6,PNP,PPAT,ITPA,ATAD1,RRM1,RRM2,ADSL,APRT,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,PDE4D,NUDT5 SMP00537 Myoadenylate deaminase deficiency 0.0682043572230245 -2.68524682727288 37 19 0.0508021390374332 374 978 10201,4860,5471,3704,84896,6240,6241,158,353,318,203,3251,957,10606,471,3614,8833,5144,11164 NME6,PNP,PPAT,ITPA,ATAD1,RRM1,RRM2,ADSL,APRT,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,PDE4D,NUDT5 SMP00050 Purine Metabolism 0.0682043572230245 -2.68524682727288 37 19 0.0508021390374332 374 978 10201,4860,5471,3704,84896,6240,6241,158,353,318,203,3251,957,10606,471,3614,8833,5144,11164 NME6,PNP,PPAT,ITPA,ATAD1,RRM1,RRM2,ADSL,APRT,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,PDE4D,NUDT5 SMP00144 Adenosine Deaminase Deficiency 0.0682043572230245 -2.68524682727288 37 19 0.0508021390374332 374 978 10201,4860,5471,3704,84896,6240,6241,158,353,318,203,3251,957,10606,471,3614,8833,5144,11164 NME6,PNP,PPAT,ITPA,ATAD1,RRM1,RRM2,ADSL,APRT,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,PDE4D,NUDT5 SMP00536 Mitochondrial DNA depletion syndrome 0.0682043572230245 -2.68524682727288 37 19 0.0508021390374332 374 978 10201,4860,5471,3704,84896,6240,6241,158,353,318,203,3251,957,10606,471,3614,8833,5144,11164 NME6,PNP,PPAT,ITPA,ATAD1,RRM1,RRM2,ADSL,APRT,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,PDE4D,NUDT5 SMP00535 Adenine phosphoribosyltransferase deficiency (APRT) 0.0682043572230245 -2.68524682727288 37 19 0.0508021390374332 374 978 10201,4860,5471,3704,84896,6240,6241,158,353,318,203,3251,957,10606,471,3614,8833,5144,11164 NME6,PNP,PPAT,ITPA,ATAD1,RRM1,RRM2,ADSL,APRT,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,PDE4D,NUDT5 SMP00512 Xanthinuria type I 0.0682043572230245 -2.68524682727288 37 19 0.0508021390374332 374 978 10201,4860,5471,3704,84896,6240,6241,158,353,318,203,3251,957,10606,471,3614,8833,5144,11164 NME6,PNP,PPAT,ITPA,ATAD1,RRM1,RRM2,ADSL,APRT,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,PDE4D,NUDT5 SMP00513 Xanthinuria type II 0.0682043572230245 -2.68524682727288 37 19 0.0508021390374332 374 978 10201,4860,5471,3704,84896,6240,6241,158,353,318,203,3251,957,10606,471,3614,8833,5144,11164 NME6,PNP,PPAT,ITPA,ATAD1,RRM1,RRM2,ADSL,APRT,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,PDE4D,NUDT5 SMP00210 Purine Nucleoside Phosphorylase Deficiency 0.0682043572230245 -2.68524682727288 37 19 0.0508021390374332 374 978 10201,4860,5471,3704,84896,6240,6241,158,353,318,203,3251,957,10606,471,3614,8833,5144,11164 NME6,PNP,PPAT,ITPA,ATAD1,RRM1,RRM2,ADSL,APRT,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,PDE4D,NUDT5 SMP00364 Lesch-Nyhan Syndrome (LNS) 0.0682043572230245 -2.68524682727288 37 19 0.0508021390374332 374 978 10201,4860,5471,3704,84896,6240,6241,158,353,318,203,3251,957,10606,471,3614,8833,5144,11164 NME6,PNP,PPAT,ITPA,ATAD1,RRM1,RRM2,ADSL,APRT,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,PDE4D,NUDT5 SMP00168 AICA-Ribosiduria 0.0682043572230245 -2.68524682727288 37 19 0.0508021390374332 374 978 10201,4860,5471,3704,84896,6240,158,6241,353,318,203,3251,957,10606,471,3614,8833,5144,11164 NME6,PNP,PPAT,ITPA,ATAD1,RRM1,ADSL,RRM2,APRT,NUDT2,AK1,HPRT1,ENTPD5,PAICS,ATIC,IMPDH1,GMPS,PDE4D,NUDT5 SMP00609 Mercaptopurine Metabolism Pathway 0.0713559238968379 -2.64007491262155 15 9 0.0240641711229947 374 978 3251,5471,3177,5879,8833,3614,2030,132,7172 HPRT1,PPAT,SLC29A2,RAC1,GMPS,IMPDH1,SLC29A1,ADK,TPMT SMP00015 Glutathione Metabolism 0.0781684089885878 -2.54888969017965 11 7 0.018716577540107 374 978 26873,840,79017,119391,2876,2729,2937 OPLAH,CASP7,GGCT,GSTO2,GPX1,GCLC,GSS SMP00500 5-oxoprolinase deficiency 0.0781684089885878 -2.54888969017965 11 7 0.018716577540107 374 978 26873,840,79017,119391,2876,2729,2937 OPLAH,CASP7,GGCT,GSTO2,GPX1,GCLC,GSS SMP00337 Glutathione Synthetase Deficiency 0.0781684089885878 -2.54888969017965 11 7 0.018716577540107 374 978 26873,840,79017,119391,2876,2729,2937 OPLAH,CASP7,GGCT,GSTO2,GPX1,GCLC,GSS SMP00143 5-Oxoprolinuria 0.0781684089885878 -2.54888969017965 11 7 0.018716577540107 374 978 26873,840,119391,79017,2876,2729,2937 OPLAH,CASP7,GSTO2,GGCT,GPX1,GCLC,GSS SMP00501 Gamma-glutamyl-transpeptidase deficiency 0.0781684089885878 -2.54888969017965 11 7 0.018716577540107 374 978 26873,840,119391,79017,2876,2729,2937 OPLAH,CASP7,GSTO2,GGCT,GPX1,GCLC,GSS SMP00183 Gamma-Glutamyltransferase Deficiency 0.0781684089885878 -2.54888969017965 11 7 0.018716577540107 374 978 26873,840,79017,119391,2876,2729,2937 OPLAH,CASP7,GGCT,GSTO2,GPX1,GCLC,GSS SMP00054 Fatty Acid Elongation In Mitochondria 0.0794736938362798 -2.53232920722086 7 5 0.0133689839572193 374 978 1892,3028,10449,51102,3032 ECHS1,HSD17B10,ACAA2,MECR,HADHB SMP00682 Leucine Stimulation on Insulin Signaling 0.0794736938362798 -2.53232920722086 7 5 0.0133689839572193 374 978 6198,3643,207,2475,6009 RPS6KB1,INSR,AKT1,MTOR,RHEB SMP00544 Long-chain-3-hydroxyacyl-coa dehydrogenase deficiency (LCHAD) 0.0794736938362798 -2.53232920722086 7 5 0.0133689839572193 374 978 1892,10449,51102,3032,3028 ECHS1,ACAA2,MECR,HADHB,HSD17B10 SMP00128 Gluconeogenesis 0.0868921366739787 -2.44308773787083 22 12 0.0320855614973262 374 978 5236,2597,5091,669,4191,226,53354,8402,5224,5223,7167,51660 PGM1,GAPDH,PC,BPGM,MDH2,ALDOA,PANK1,SLC25A11,PGAM2,PGAM1,TPI1,MPC1 SMP00581 Glycogenosis- Type IA. Von gierke disease 0.0868921366739787 -2.44308773787083 22 12 0.0320855614973262 374 978 5236,2597,5091,669,4191,226,53354,8402,5224,5223,7167,51660 PGM1,GAPDH,PC,BPGM,MDH2,ALDOA,PANK1,SLC25A11,PGAM2,PGAM1,TPI1,MPC1 SMP00574 Glycogenosis- Type IC 0.0868921366739787 -2.44308773787083 22 12 0.0320855614973262 374 978 5236,2597,5091,669,4191,226,53354,5224,8402,5223,51660,7167 PGM1,GAPDH,PC,BPGM,MDH2,ALDOA,PANK1,PGAM2,SLC25A11,PGAM1,MPC1,TPI1 SMP00563 Triosephosphate isomerase 0.0868921366739787 -2.44308773787083 22 12 0.0320855614973262 374 978 5236,2597,5091,669,4191,226,53354,8402,5224,5223,7167,51660 PGM1,GAPDH,PC,BPGM,MDH2,ALDOA,PANK1,SLC25A11,PGAM2,PGAM1,TPI1,MPC1 SMP00562 Fructose-1-6-diphosphatase deficiency 0.0868921366739787 -2.44308773787083 22 12 0.0320855614973262 374 978 5236,2597,5091,669,4191,226,53354,5224,8402,5223,51660,7167 PGM1,GAPDH,PC,BPGM,MDH2,ALDOA,PANK1,PGAM2,SLC25A11,PGAM1,MPC1,TPI1 SMP00374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 0.0868921366739787 -2.44308773787083 22 12 0.0320855614973262 374 978 5236,2597,5091,669,4191,226,53354,8402,5224,5223,7167,51660 PGM1,GAPDH,PC,BPGM,MDH2,ALDOA,PANK1,SLC25A11,PGAM2,PGAM1,TPI1,MPC1 SMP00560 Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1) 0.0868921366739787 -2.44308773787083 22 12 0.0320855614973262 374 978 5236,2597,5091,669,4191,226,53354,8402,5224,5223,7167,51660 PGM1,GAPDH,PC,BPGM,MDH2,ALDOA,PANK1,SLC25A11,PGAM2,PGAM1,TPI1,MPC1 SMP00573 Glycogenosis- Type IB 0.0868921366739787 -2.44308773787083 22 12 0.0320855614973262 374 978 5236,2597,5091,669,4191,226,53354,8402,5224,5223,7167,51660 PGM1,GAPDH,PC,BPGM,MDH2,ALDOA,PANK1,SLC25A11,PGAM2,PGAM1,TPI1,MPC1 SMP00320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine 0.0895238968180557 -2.41324968578674 38 19 0.0508021390374332 374 978 5170,5599,673,207,5609,2782,1147,5605,2778,5906,5608,3551,5590,4791,1386,5594,3265,5567,4214 PDPK1,MAPK8,BRAF,AKT1,MAP2K7,GNB1,CHUK,MAP2K2,GNAS,RAP1A,MAP2K6,IKBKB,PRKCZ,NFKB2,ATF2,MAPK1,HRAS,PRKACB,MAP3K1 SMP00321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine 0.0895238968180557 -2.41324968578674 38 19 0.0508021390374332 374 978 5170,5599,673,5609,207,2782,1147,5605,2778,5906,5608,3551,5590,4791,1386,5594,3265,5567,4214 PDPK1,MAPK8,BRAF,MAP2K7,AKT1,GNB1,CHUK,MAP2K2,GNAS,RAP1A,MAP2K6,IKBKB,PRKCZ,NFKB2,ATF2,MAPK1,HRAS,PRKACB,MAP3K1 SMP00725 Fructose intolerance- hereditary 0.101458198422039 -2.28810840353546 18 10 0.0267379679144385 374 978 5372,197258,4351,5211,226,231,29925,3098,3795,7167 PMM1,FUK,MPI,PFKL,ALDOA,AKR1B1,GMPPB,HK1,KHK,TPI1 SMP00561 Fructosuria 0.101458198422039 -2.28810840353546 18 10 0.0267379679144385 374 978 5372,197258,4351,5211,226,231,29925,3098,3795,7167 PMM1,FUK,MPI,PFKL,ALDOA,AKR1B1,GMPPB,HK1,KHK,TPI1 SMP00064 Fructose and Mannose Degradation 0.101458198422039 -2.28810840353546 18 10 0.0267379679144385 374 978 5372,197258,4351,5211,226,231,29925,3098,3795,7167 PMM1,FUK,MPI,PFKL,ALDOA,AKR1B1,GMPPB,HK1,KHK,TPI1 SMP00543 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 0.127548188433072 -2.05926103729351 12 7 0.018716577540107 374 978 1719,10797,25902,123263,10588,2356,4522 DHFR,MTHFD2,MTHFD1L,MTFMT,MTHFS,FPGS,MTHFD1 SMP00053 Folate Metabolism 0.127548188433072 -2.05926103729351 12 7 0.018716577540107 374 978 1719,10797,25902,123263,10588,2356,4522 DHFR,MTHFD2,MTHFD1L,MTFMT,MTHFS,FPGS,MTHFD1 SMP00432 Methotrexate Action Pathway 0.127548188433072 -2.05926103729351 12 7 0.018716577540107 374 978 1719,10797,25902,123263,10588,2356,4522 DHFR,MTHFD2,MTHFD1L,MTFMT,MTHFS,FPGS,MTHFD1 SMP00724 Folate malabsorption- hereditary 0.127548188433072 -2.05926103729351 12 7 0.018716577540107 374 978 1719,10797,25902,123263,10588,2356,4522 DHFR,MTHFD2,MTHFD1L,MTFMT,MTHFS,FPGS,MTHFD1 SMP00011 Inositol Metabolism 0.131772072693074 -2.02668157092074 21 11 0.0294117647058824 374 978 3612,64768,253430,30849,5297,51477,9896,3706,200576,55626,55697 IMPA1,IPPK,IPMK,PIK3R4,PI4KA,ISYNA1,FIG4,ITPKA,PIKFYVE,AMBRA1,VAC14 SMP00456 Fatty Acid Biosynthesis 0.145998036642414 -1.92416210501892 2 2 0.0053475935828877 374 978 31,2194 ACACA,FASN SMP00487 Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency 0.146689691654752 -1.91943586450423 8 5 0.0133689839572193 374 978 5805,231,1719,2644,2643 PTS,AKR1B1,DHFR,GCHFR,GCH1 SMP00496 Galactosemia III 0.146689691654752 -1.91943586450423 8 5 0.0133689839572193 374 978 80146,5236,7360,7358,2582 UXS1,PGM1,UGP2,UGDH,GALE SMP00005 Pterine Biosynthesis 0.146689691654752 -1.91943586450423 8 5 0.0133689839572193 374 978 1719,5805,231,2644,2643 DHFR,PTS,AKR1B1,GCHFR,GCH1 SMP00488 Hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency (ptps) 0.146689691654752 -1.91943586450423 8 5 0.0133689839572193 374 978 1719,5805,231,2644,2643 DHFR,PTS,AKR1B1,GCHFR,GCH1 SMP00495 Galactosemia II (GALK) 0.146689691654752 -1.91943586450423 8 5 0.0133689839572193 374 978 80146,5236,7360,7358,2582 UXS1,PGM1,UGP2,UGDH,GALE SMP00010 Nucleotide Sugars Metabolism 0.146689691654752 -1.91943586450423 8 5 0.0133689839572193 374 978 80146,5236,7360,7358,2582 UXS1,PGM1,UGP2,UGDH,GALE SMP00490 Segawa syndrome 0.146689691654752 -1.91943586450423 8 5 0.0133689839572193 374 978 1719,5805,231,2644,2643 DHFR,PTS,AKR1B1,GCHFR,GCH1 SMP00491 Sepiapterin reductase deficiency 0.146689691654752 -1.91943586450423 8 5 0.0133689839572193 374 978 1719,5805,231,2644,2643 DHFR,PTS,AKR1B1,GCHFR,GCH1 SMP00486 Dopa-responsive dystonia 0.146689691654752 -1.91943586450423 8 5 0.0133689839572193 374 978 1719,5805,231,2644,2643 DHFR,PTS,AKR1B1,GCHFR,GCH1 SMP00489 Hyperphenylalaninemia due to dhpr-deficiency 0.146689691654752 -1.91943586450423 8 5 0.0133689839572193 374 978 1719,5805,231,2644,2643 DHFR,PTS,AKR1B1,GCHFR,GCH1 SMP00445 Spermidine and Spermine Biosynthesis 0.155072227289258 -1.86386428808768 6 4 0.0106951871657754 374 978 6723,4953,4144,262 SRM,ODC1,MAT2A,AMD1 SMP00478 Nucleotide Excision Repair 0.155072227289258 -1.86386428808768 6 4 0.0106951871657754 374 978 3978,2072,2068,5426 LIG1,ERCC4,ERCC2,POLE SMP00390 Tay-Sachs Disease 0.157059077174245 -1.85113325667826 17 9 0.0240641711229947 374 978 2673,64841,10007,10020,5238,51005,26503,3098,3073 GFPT1,GNPNAT1,GNPDA1,GNE,PGM3,AMDHD2,SLC17A5,HK1,HEXA SMP00045 Amino Sugar Metabolism 0.157059077174245 -1.85113325667826 17 9 0.0240641711229947 374 978 2673,64841,10007,10020,5238,51005,26503,3098,3073 GFPT1,GNPNAT1,GNPDA1,GNE,PGM3,AMDHD2,SLC17A5,HK1,HEXA SMP00240 Salla Disease/Infantile Sialic Acid Storage Disease 0.157059077174245 -1.85113325667826 17 9 0.0240641711229947 374 978 2673,64841,10007,10020,5238,51005,26503,3098,3073 GFPT1,GNPNAT1,GNPDA1,GNE,PGM3,AMDHD2,SLC17A5,HK1,HEXA SMP00534 G(M2)-Gangliosidosis: Variant B- Tay-sachs disease 0.157059077174245 -1.85113325667826 17 9 0.0240641711229947 374 978 2673,64841,10007,10020,5238,51005,26503,3098,3073 GFPT1,GNPNAT1,GNPDA1,GNE,PGM3,AMDHD2,SLC17A5,HK1,HEXA SMP00216 Sialuria or French Type Sialuria 0.157059077174245 -1.85113325667826 17 9 0.0240641711229947 374 978 2673,64841,10007,10020,5238,51005,26503,3098,3073 GFPT1,GNPNAT1,GNPDA1,GNE,PGM3,AMDHD2,SLC17A5,HK1,HEXA SMP00217 Sialuria or French Type Sialuria 0.157059077174245 -1.85113325667826 17 9 0.0240641711229947 374 978 2673,64841,10007,10020,5238,51005,26503,3098,3073 GFPT1,GNPNAT1,GNPDA1,GNE,PGM3,AMDHD2,SLC17A5,HK1,HEXA SMP00076 Thiamine Metabolism 0.159064216541872 -1.83844728067668 4 3 0.00802139037433155 374 978 84284,10560,27010 NTPCR,SLC19A2,TPK1 SMP00450 Phytanic Acid Peroxisomal Oxidation 0.159064216541872 -1.83844728067668 4 3 0.00802139037433155 374 978 11001,224,5264 SLC27A2,ALDH3A2,PHYH SMP00629 Adefovir Dipivoxil Metabolism Pathway 0.159064216541872 -1.83844728067668 4 3 0.00802139037433155 374 978 203,4830,4831 AK1,NME1,NME2 SMP00451 Refsum Disease 0.159064216541872 -1.83844728067668 4 3 0.00802139037433155 374 978 11001,224,5264 SLC27A2,ALDH3A2,PHYH SMP00630 Tenofovir Metabolism Pathway 0.159064216541872 -1.83844728067668 4 3 0.00802139037433155 374 978 203,4830,4831 AK1,NME1,NME2 SMP00060 Pyruvate Metabolism 0.176652008712249 -1.73357353409955 22 11 0.0294117647058824 374 978 5160,9380,5091,97,38,231,4190,4199,4200,197257,31 PDHA1,GRHPR,PC,ACYP1,ACAT1,AKR1B1,MDH1,ME1,ME2,LDHD,ACACA SMP00136 2-Hydroxyglutric Aciduria (D And L Form) 0.176652008712249 -1.73357353409955 22 11 0.0294117647058824 374 978 2673,8659,124454,1373,64841,5471,2806,2729,8833,2571,2937 GFPT1,ALDH4A1,EARS2,CPS1,GNPNAT1,PPAT,GOT2,GCLC,GMPS,GAD1,GSS SMP00567 Succinic semialdehyde dehydrogenase deficiency 0.176652008712249 -1.73357353409955 22 11 0.0294117647058824 374 978 2673,8659,1373,124454,64841,5471,2806,2729,8833,2571,2937 GFPT1,ALDH4A1,CPS1,EARS2,GNPNAT1,PPAT,GOT2,GCLC,GMPS,GAD1,GSS SMP00339 Hyperinsulinism-Hyperammonemia Syndrome 0.176652008712249 -1.73357353409955 22 11 0.0294117647058824 374 978 2673,8659,124454,1373,64841,5471,2806,2729,8833,2571,2937 GFPT1,ALDH4A1,EARS2,CPS1,GNPNAT1,PPAT,GOT2,GCLC,GMPS,GAD1,GSS SMP00334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) 0.176652008712249 -1.73357353409955 22 11 0.0294117647058824 374 978 5160,9380,5091,97,38,231,4190,4199,4200,197257,31 PDHA1,GRHPR,PC,ACYP1,ACAT1,AKR1B1,MDH1,ME1,ME2,LDHD,ACACA SMP00243 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency 0.176652008712249 -1.73357353409955 22 11 0.0294117647058824 374 978 2673,8659,124454,1373,64841,5471,2806,2729,8833,2571,2937 GFPT1,ALDH4A1,EARS2,CPS1,GNPNAT1,PPAT,GOT2,GCLC,GMPS,GAD1,GSS SMP00196 Leigh Syndrome 0.176652008712249 -1.73357353409955 22 11 0.0294117647058824 374 978 5160,9380,5091,97,38,231,4190,4199,4200,197257,31 PDHA1,GRHPR,PC,ACYP1,ACAT1,AKR1B1,MDH1,ME1,ME2,LDHD,ACACA SMP00212 Pyruvate Dehydrogenase Complex Deficiency 0.176652008712249 -1.73357353409955 22 11 0.0294117647058824 374 978 5160,9380,5091,97,38,231,4190,4199,4200,197257,31 PDHA1,GRHPR,PC,ACYP1,ACAT1,AKR1B1,MDH1,ME1,ME2,LDHD,ACACA SMP00385 Homocarnosinosis 0.176652008712249 -1.73357353409955 22 11 0.0294117647058824 374 978 2673,8659,124454,1373,64841,5471,2806,2729,8833,2571,2937 GFPT1,ALDH4A1,EARS2,CPS1,GNPNAT1,PPAT,GOT2,GCLC,GMPS,GAD1,GSS SMP00558 Primary hyperoxaluria II- PH2 0.176652008712249 -1.73357353409955 22 11 0.0294117647058824 374 978 5160,9380,5091,97,38,231,4190,4199,4200,197257,31 PDHA1,GRHPR,PC,ACYP1,ACAT1,AKR1B1,MDH1,ME1,ME2,LDHD,ACACA SMP00072 Glutamate Metabolism 0.176652008712249 -1.73357353409955 22 11 0.0294117647058824 374 978 2673,8659,124454,1373,64841,5471,2806,2729,8833,2571,2937 GFPT1,ALDH4A1,EARS2,CPS1,GNPNAT1,PPAT,GOT2,GCLC,GMPS,GAD1,GSS SMP00559 Pyruvate kinase deficiency 0.176652008712249 -1.73357353409955 22 11 0.0294117647058824 374 978 5160,9380,5091,97,38,231,4190,4199,4200,197257,31 PDHA1,GRHPR,PC,ACYP1,ACAT1,AKR1B1,MDH1,ME1,ME2,LDHD,ACACA SMP00002 Carbamoyl Phosphate Synthetase Deficiency 0.188787293790227 -1.66713432737537 13 7 0.018716577540107 374 978 8604,10166,1373,6510,6509,2806,435 SLC25A12,SLC25A15,CPS1,SLC1A5,SLC1A4,GOT2,ASL SMP00003 Argininosuccinic Aciduria 0.188787293790227 -1.66713432737537 13 7 0.018716577540107 374 978 8604,10166,1373,6510,6509,2806,435 SLC25A12,SLC25A15,CPS1,SLC1A5,SLC1A4,GOT2,ASL SMP00205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) 0.188787293790227 -1.66713432737537 13 7 0.018716577540107 374 978 8604,1373,10166,6510,6509,2806,435 SLC25A12,CPS1,SLC25A15,SLC1A5,SLC1A4,GOT2,ASL SMP00357 Argininemia 0.188787293790227 -1.66713432737537 13 7 0.018716577540107 374 978 8604,10166,1373,6510,6509,2806,435 SLC25A12,SLC25A15,CPS1,SLC1A5,SLC1A4,GOT2,ASL SMP00001 Citrullinemia Type I 0.188787293790227 -1.66713432737537 13 7 0.018716577540107 374 978 8604,10166,1373,6510,6509,2806,435 SLC25A12,SLC25A15,CPS1,SLC1A5,SLC1A4,GOT2,ASL SMP00059 Urea Cycle 0.188787293790227 -1.66713432737537 13 7 0.018716577540107 374 978 8604,1373,10166,6510,6509,2806,435 SLC25A12,CPS1,SLC25A15,SLC1A5,SLC1A4,GOT2,ASL SMP00187 Glycerol Kinase Deficiency 0.207924514213193 -1.57058017758604 11 6 0.0160427807486631 374 978 231,2710,57678,132158,2819,10554 AKR1B1,GK,GPAM,GLYCTK,GPD1,AGPAT1 SMP00530 Familial lipoprotein lipase deficiency 0.207924514213193 -1.57058017758604 11 6 0.0160427807486631 374 978 231,2710,57678,132158,2819,10554 AKR1B1,GK,GPAM,GLYCTK,GPD1,AGPAT1 SMP00529 D-glyceric acidura 0.207924514213193 -1.57058017758604 11 6 0.0160427807486631 374 978 231,2710,57678,132158,2819,10554 AKR1B1,GK,GPAM,GLYCTK,GPD1,AGPAT1 SMP00039 Glycerolipid Metabolism 0.207924514213193 -1.57058017758604 11 6 0.0160427807486631 374 978 231,2710,57678,132158,2819,10554 AKR1B1,GK,GPAM,GLYCTK,GPD1,AGPAT1 SMP00522 3-hydroxyisobutyric aciduria 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,10449,3028,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,ACAA2,HSD17B10,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00524 Isovaleric acidemia 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,10449,3028,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,ACAA2,HSD17B10,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00523 Isobutyryl-coa dehydrogenase deficiency 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,10449,3028,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,ACAA2,HSD17B10,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00237 3-Methylcrotonyl Coa Carboxylase Deficiency Type I 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,10449,3028,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,ACAA2,HSD17B10,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00238 Isovaleric Aciduria 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,10449,3028,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,ACAA2,HSD17B10,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00199 Maple Syrup Urine Disease 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,10449,3028,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,ACAA2,HSD17B10,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00521 3-hydroxyisobutyric acid dehydrogenase deficiency 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,10449,3028,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,ACAA2,HSD17B10,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00236 Propionic Acidemia 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,10449,3028,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,ACAA2,HSD17B10,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00200 Methylmalonic Aciduria 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,10449,3028,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,ACAA2,HSD17B10,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00384 Methylmalonate Semialdehyde Dehydrogenase Deficiency 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,3028,10449,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,HSD17B10,ACAA2,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00140 3-Methylglutaconic Aciduria Type III 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,3028,10449,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,HSD17B10,ACAA2,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00139 3-Methylglutaconic Aciduria Type I 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,3028,10449,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,HSD17B10,ACAA2,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00032 Valine- Leucine and Isoleucine Degradation 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,3028,10449,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,HSD17B10,ACAA2,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00173 Beta-Ketothiolase Deficiency 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,10449,3028,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,ACAA2,HSD17B10,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00141 3-Methylglutaconic Aciduria Type IV 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,10449,3028,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,ACAA2,HSD17B10,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00137 2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,10449,3028,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,ACAA2,HSD17B10,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00138 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency 0.218080243185508 -1.5228921959139 30 14 0.0374331550802139 374 978 84693,5096,36,4329,594,593,1892,10449,3028,56922,38,3155,27034,1629 MCEE,PCCB,ACADSB,ALDH6A1,BCKDHB,BCKDHA,ECHS1,ACAA2,HSD17B10,MCCC1,ACAT1,HMGCL,ACAD8,DBT SMP00452 Threonine and 2-Oxobutanoate Degradation 0.229982093075389 -1.46975382928386 9 5 0.0133689839572193 374 978 84693,5096,594,593,1629 MCEE,PCCB,BCKDHB,BCKDHA,DBT SMP00582 Joubert syndrome 0.249766849534457 -1.38722739812575 21 10 0.0267379679144385 374 978 5295,30849,2064,5297,9896,8394,10423,200576,55697,55626 PIK3R1,PIK3R4,ERBB2,PI4KA,FIG4,PIP5K1A,CDIPT,PIKFYVE,VAC14,AMBRA1 SMP00463 Phosphatidylinositol Phosphate Metabolism 0.249766849534457 -1.38722739812575 21 10 0.0267379679144385 374 978 5295,30849,2064,5297,9896,8394,10423,200576,55697,55626 PIK3R1,PIK3R4,ERBB2,PI4KA,FIG4,PIP5K1A,CDIPT,PIKFYVE,VAC14,AMBRA1 SMP00185 Glutaric Aciduria Type I 0.259264392982514 -1.34990691564108 14 7 0.018716577540107 374 978 38,2180,36,2639,1892,10449,3032 ACAT1,ACSL1,ACADSB,GCDH,ECHS1,ACAA2,HADHB SMP00540 Very-long-chain acyl coa dehydrogenase deficiency (VLCAD) 0.259264392982514 -1.34990691564108 14 7 0.018716577540107 374 978 38,2180,36,2639,1892,10449,3032 ACAT1,ACSL1,ACADSB,GCDH,ECHS1,ACAA2,HADHB SMP00545 Trifunctional protein deficiency 0.259264392982514 -1.34990691564108 14 7 0.018716577540107 374 978 38,2180,36,2639,1892,10449,3032 ACAT1,ACSL1,ACADSB,GCDH,ECHS1,ACAA2,HADHB SMP00542 Medium chain acyl-coa dehydrogenase deficiency (MCAD) 0.259264392982514 -1.34990691564108 14 7 0.018716577540107 374 978 38,2180,36,2639,1892,10449,3032 ACAT1,ACSL1,ACADSB,GCDH,ECHS1,ACAA2,HADHB SMP00235 Short Chain Acyl CoA Dehydrogenase Deficiency (SCAD Deficiency) 0.259264392982514 -1.34990691564108 14 7 0.018716577540107 374 978 38,2180,36,2639,1892,10449,3032 ACAT1,ACSL1,ACADSB,GCDH,ECHS1,ACAA2,HADHB SMP00181 Ethylmalonic Encephalopathy 0.259264392982514 -1.34990691564108 14 7 0.018716577540107 374 978 38,2180,36,2639,1892,10449,3032 ACAT1,ACSL1,ACADSB,GCDH,ECHS1,ACAA2,HADHB SMP00462 Inositol Phosphate Metabolism 0.259264392982514 -1.34990691564108 14 7 0.018716577540107 374 978 3612,64768,51477,3706,9807,11165,253430 IMPA1,IPPK,ISYNA1,ITPKA,IP6K1,NUDT3,IPMK SMP00538 Carnitine palmitoyl transferase deficiency (I) 0.259264392982514 -1.34990691564108 14 7 0.018716577540107 374 978 38,2180,36,2639,1892,10449,3032 ACAT1,ACSL1,ACADSB,GCDH,ECHS1,ACAA2,HADHB SMP00541 Carnitine palmitoyl transferase deficiency (II) 0.259264392982514 -1.34990691564108 14 7 0.018716577540107 374 978 38,2180,36,2639,1892,10449,3032 ACAT1,ACSL1,ACADSB,GCDH,ECHS1,ACAA2,HADHB SMP00051 Fatty acid Metabolism 0.259264392982514 -1.34990691564108 14 7 0.018716577540107 374 978 38,2180,36,2639,1892,10449,3032 ACAT1,ACSL1,ACADSB,GCDH,ECHS1,ACAA2,HADHB SMP00539 Long chain acyl-CoA dehydrogenase deficiency (LCAD) 0.259264392982514 -1.34990691564108 14 7 0.018716577540107 374 978 38,2180,36,2639,1892,10449,3032 ACAT1,ACSL1,ACADSB,GCDH,ECHS1,ACAA2,HADHB SMP00025 Phospholipid Biosynthesis 0.25946802348475 -1.34912180753435 26 12 0.0320855614973262 374 978 10400,23659,10554,162466,10434,81490,57678,10423,9791,5130,1119,2819 PEMT,PLA2G15,AGPAT1,PHOSPHO1,LYPLA1,PTDSS2,GPAM,CDIPT,PTDSS1,PCYT1A,CHKA,GPD1 SMP00055 Alanine Metabolism 0.287114948791613 -1.24787262497094 5 3 0.00802139037433155 374 978 5091,16,57505 PC,AARS,AARS2 SMP00352 Primary Hyperoxaluria Type I 0.287114948791613 -1.24787262497094 5 3 0.00802139037433155 374 978 5091,16,57505 PC,AARS,AARS2 SMP00021 Taurine and Hypotaurine Metabolism 0.287114948791613 -1.24787262497094 5 3 0.00802139037433155 374 978 51380,2571,84890 CSAD,GAD1,ADO SMP00516 Adrenoleukodystrophy- X-linked 0.287114948791613 -1.24787262497094 5 3 0.00802139037433155 374 978 2180,1384,54677 ACSL1,CRAT,CROT SMP00350 Pyruvate Carboxylase Deficiency 0.287114948791613 -1.24787262497094 5 3 0.00802139037433155 374 978 5091,16,57505 PC,AARS,AARS2 SMP00052 Beta Oxidation of Very Long Chain Fatty Acids 0.287114948791613 -1.24787262497094 5 3 0.00802139037433155 374 978 2180,1384,54677 ACSL1,CRAT,CROT SMP00313 Lactic Acidemia 0.287114948791613 -1.24787262497094 5 3 0.00802139037433155 374 978 5091,16,57505 PC,AARS,AARS2 SMP00517 Carnitine-acylcarnitine translocase deficiency 0.287114948791613 -1.24787262497094 5 3 0.00802139037433155 374 978 2180,1384,54677 ACSL1,CRAT,CROT SMP00310 Corticotropin Activation of Cortisol Production 0.287114948791613 -1.24787262497094 5 3 0.00802139037433155 374 978 2778,2782,5567 GNAS,GNB1,PRKACB SMP00124 Glycerol Phosphate Shuttle 0.326700524617088 -1.11871135456958 3 2 0.0053475935828877 374 978 2597,2819 GAPDH,GPD1 SMP00345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease 0.335645045868056 -1.09170108852142 15 7 0.018716577540107 374 978 644,210,7390,5498,1371,7389,211 BLVRA,ALAD,UROS,PPOX,CPOX,UROD,ALAS1 SMP00344 Acute Intermittent Porphyria 0.335645045868056 -1.09170108852142 15 7 0.018716577540107 374 978 644,210,7390,5498,1371,7389,211 BLVRA,ALAD,UROS,PPOX,CPOX,UROD,ALAS1 SMP00040 Glycolysis 0.335645045868056 -1.09170108852142 15 7 0.018716577540107 374 978 5224,2597,5223,669,7167,226,53354 PGAM2,GAPDH,PGAM1,BPGM,TPI1,ALDOA,PANK1 SMP00024 Porphyrin Metabolism 0.335645045868056 -1.09170108852142 15 7 0.018716577540107 374 978 644,210,7390,5498,1371,7389,211 BLVRA,ALAD,UROS,PPOX,CPOX,UROD,ALAS1 SMP00531 Glycogenosis- Type VII. Tarui disease 0.335645045868056 -1.09170108852142 15 7 0.018716577540107 374 978 5224,2597,5223,669,7167,226,53354 PGAM2,GAPDH,PGAM1,BPGM,TPI1,ALDOA,PANK1 SMP00342 Hereditary Coproporphyria (HCP) 0.335645045868056 -1.09170108852142 15 7 0.018716577540107 374 978 644,210,7390,5498,1371,7389,211 BLVRA,ALAD,UROS,PPOX,CPOX,UROD,ALAS1 SMP00346 Porphyria Variegata (PV) 0.335645045868056 -1.09170108852142 15 7 0.018716577540107 374 978 644,210,7390,5498,1371,7389,211 BLVRA,ALAD,UROS,PPOX,CPOX,UROD,ALAS1 SMP00572 Fanconi-bickel syndrome 0.335645045868056 -1.09170108852142 15 7 0.018716577540107 374 978 5224,2597,5223,669,7167,226,53354 PGAM2,GAPDH,PGAM1,BPGM,TPI1,ALDOA,PANK1 SMP00030 Oxidation of Branched Chain Fatty Acids 0.365050852134627 -1.00771861418712 8 4 0.0106951871657754 374 978 2180,1384,54677,5264 ACSL1,CRAT,CROT,PHYH SMP00127 Glucose-Alanine Cycle 0.365050852134627 -1.00771861418712 8 4 0.0106951871657754 374 978 84706,79751,6517,6509 GPT2,SLC25A22,SLC2A4,SLC1A4 SMP00480 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids 0.365050852134627 -1.00771861418712 8 4 0.0106951871657754 374 978 38,1892,10449,3028 ACAT1,ECHS1,ACAA2,HSD17B10 SMP00568 Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (SCHAD) 0.365050852134627 -1.00771861418712 8 4 0.0106951871657754 374 978 38,1892,10449,3028 ACAT1,ECHS1,ACAA2,HSD17B10 SMP00554 Glycogenosis- Type IV. Amylopectinosis 0.373598165313093 -0.9845744834717 13 6 0.0160427807486631 374 978 283209,2632,5236,7360,178,7358 PGM2L1,GBE1,PGM1,UGP2,AGL,UGDH SMP00043 Galactose Metabolism 0.373598165313093 -0.9845744834717 13 6 0.0160427807486631 374 978 231,5236,3098,2717,7360,2582 AKR1B1,PGM1,HK1,GLA,UGP2,GALE SMP00553 Glycogenosis- Type III. Cori disease 0.373598165313093 -0.9845744834717 13 6 0.0160427807486631 374 978 283209,2632,5236,7360,178,7358 PGM2L1,GBE1,PGM1,UGP2,AGL,UGDH SMP00182 Galactosemia 0.373598165313093 -0.9845744834717 13 6 0.0160427807486631 374 978 231,5236,3098,2717,7360,2582 AKR1B1,PGM1,HK1,GLA,UGP2,GALE SMP00632 Prednisolone Metabolism Pathway 0.382413087934722 -0.961253872619864 1 1 0.00267379679144385 374 978 3320 HSP90AA1 SMP00647 Thioguanine Metabolism Pathway 0.382413087934722 -0.961253872619864 1 1 0.00267379679144385 374 978 3251 HPRT1 SMP00470 Fluorouracil Action Pathway 0.382413087934722 -0.961253872619864 1 1 0.00267379679144385 374 978 7298 TYMS SMP00263 Cilostazol Action Pathway 0.382413087934722 -0.961253872619864 1 1 0.00267379679144385 374 978 5144 PDE4D SMP00264 Dipyridamole (Antiplatelet) Action Pathway 0.382413087934722 -0.961253872619864 1 1 0.00267379679144385 374 978 5144 PDE4D SMP00441 Prednisolone Action Pathway 0.382413087934722 -0.961253872619864 1 1 0.00267379679144385 374 978 3320 HSP90AA1 SMP00608 Fluorouracil Metabolism Pathway 0.382413087934722 -0.961253872619864 1 1 0.00267379679144385 374 978 7298 TYMS SMP00009 Ammonia Recycling 0.418558408602361 -0.870938832238278 11 5 0.0133689839572193 374 978 1373,440,80150,2653,2731 CPS1,ASNS,ASRGL1,GCSH,GLDC SMP00343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 0.419157670296104 -0.86950812842094 6 3 0.00802139037433155 374 978 2778,2782,5567 GNAS,GNB1,PRKACB SMP00308 Dopamine Activation of Neurological Reward System 0.419157670296104 -0.86950812842094 6 3 0.00802139037433155 374 978 2778,2782,5567 GNAS,GNB1,PRKACB SMP00340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 0.448576307454311 -0.801676472703799 19 8 0.0213903743315508 374 978 253827,6723,55349,123263,4144,262,4507,1491 MSRB3,SRM,CHDH,MTFMT,MAT2A,AMD1,MTAP,CTH SMP00214 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency 0.448576307454311 -0.801676472703799 19 8 0.0213903743315508 374 978 253827,6723,55349,123263,262,4507,4144,1491 MSRB3,SRM,CHDH,MTFMT,AMD1,MTAP,MAT2A,CTH SMP00221 Methionine Adenosyltransferase Deficiency 0.448576307454311 -0.801676472703799 19 8 0.0213903743315508 374 978 253827,6723,55349,123263,4144,262,4507,1491 MSRB3,SRM,CHDH,MTFMT,MAT2A,AMD1,MTAP,CTH SMP00177 Cystathionine Beta-Synthase Deficiency 0.448576307454311 -0.801676472703799 19 8 0.0213903743315508 374 978 253827,6723,55349,123263,4144,262,4507,1491 MSRB3,SRM,CHDH,MTFMT,MAT2A,AMD1,MTAP,CTH SMP00341 Hypermethioninemia 0.448576307454311 -0.801676472703799 19 8 0.0213903743315508 374 978 253827,6723,55349,123263,262,4507,4144,1491 MSRB3,SRM,CHDH,MTFMT,AMD1,MTAP,MAT2A,CTH SMP00033 Methionine Metabolism 0.448576307454311 -0.801676472703799 19 8 0.0213903743315508 374 978 253827,6723,55349,123263,4144,262,4507,1491 MSRB3,SRM,CHDH,MTFMT,MAT2A,AMD1,MTAP,CTH SMP00222 Glycine N-methyltransferase Deficiency 0.448576307454311 -0.801676472703799 19 8 0.0213903743315508 374 978 253827,6723,55349,123263,4144,262,4507,1491 MSRB3,SRM,CHDH,MTFMT,MAT2A,AMD1,MTAP,CTH SMP00570 Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism- cblG complementation type 0.448576307454311 -0.801676472703799 19 8 0.0213903743315508 374 978 253827,6723,55349,123263,4144,262,4507,1491 MSRB3,SRM,CHDH,MTFMT,MAT2A,AMD1,MTAP,CTH SMP00198 Malonic Aciduria 0.459348494561344 -0.777946109593763 14 6 0.0160427807486631 374 978 38,84693,5096,4329,31,1892 ACAT1,MCEE,PCCB,ALDH6A1,ACACA,ECHS1 SMP00201 Methylmalonic Aciduria Due to Cobalamin-Related Disorders 0.459348494561344 -0.777946109593763 14 6 0.0160427807486631 374 978 38,84693,5096,4329,31,1892 ACAT1,MCEE,PCCB,ALDH6A1,ACACA,ECHS1 SMP00067 Aspartate Metabolism 0.459348494561344 -0.777946109593763 14 6 0.0160427807486631 374 978 158,440,80150,2571,122622,435 ADSL,ASNS,ASRGL1,GAD1,ADSSL1,ASL SMP00175 Canavan Disease 0.459348494561344 -0.777946109593763 14 6 0.0160427807486631 374 978 158,440,80150,2571,122622,435 ADSL,ASNS,ASRGL1,GAD1,ADSSL1,ASL SMP00192 Hypoacetylaspartia 0.459348494561344 -0.777946109593763 14 6 0.0160427807486631 374 978 158,440,80150,2571,122622,435 ADSL,ASNS,ASRGL1,GAD1,ADSSL1,ASL SMP00502 Malonyl-coa decarboxylase deficiency 0.459348494561344 -0.777946109593763 14 6 0.0160427807486631 374 978 38,84693,5096,4329,31,1892 ACAT1,MCEE,PCCB,ALDH6A1,ACACA,ECHS1 SMP00016 Propanoate Metabolism 0.459348494561344 -0.777946109593763 14 6 0.0160427807486631 374 978 38,84693,5096,4329,31,1892 ACAT1,MCEE,PCCB,ALDH6A1,ACACA,ECHS1 SMP00580 GLUT-1 deficiency syndrome 0.473105859383276 -0.748436111337653 9 4 0.0106951871657754 374 978 124583,51727,7360,4831 CANT1,CMPK1,UGP2,NME2 SMP00444 Lactose Synthesis 0.473105859383276 -0.748436111337653 9 4 0.0106951871657754 374 978 124583,51727,7360,4831 CANT1,CMPK1,UGP2,NME2 SMP00335 Intracellular Signalling Through Histamine H2 Receptor and Histamine 0.473105859383276 -0.748436111337653 9 4 0.0106951871657754 374 978 2778,2782,5499,5567 GNAS,GNB1,PPP1CA,PRKACB SMP00499 Beta-mercaptolactate-cysteine disulfiduria 0.473105859383276 -0.748436111337653 9 4 0.0106951871657754 374 978 833,2729,4357,1491 CARS,GCLC,MPST,CTH SMP00333 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone 0.473105859383276 -0.748436111337653 9 4 0.0106951871657754 374 978 2778,2782,5499,5567 GNAS,GNB1,PPP1CA,PRKACB SMP00013 Cysteine Metabolism 0.473105859383276 -0.748436111337653 9 4 0.0106951871657754 374 978 833,2729,4357,1491 CARS,GCLC,MPST,CTH SMP00722 Cystinosis- ocular nonnephropathic 0.473105859383276 -0.748436111337653 9 4 0.0106951871657754 374 978 833,2729,4357,1491 CARS,GCLC,MPST,CTH SMP00312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin 0.473105859383276 -0.748436111337653 9 4 0.0106951871657754 374 978 2778,2782,5499,5567 GNAS,GNB1,PPP1CA,PRKACB SMP00309 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin 0.473105859383276 -0.748436111337653 9 4 0.0106951871657754 374 978 2778,2782,5499,5567 GNAS,GNB1,PPP1CA,PRKACB SMP00311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin 0.473105859383276 -0.748436111337653 9 4 0.0106951871657754 374 978 2778,2782,5499,5567 GNAS,GNB1,PPP1CA,PRKACB SMP00579 Congenital disorder of glycosylation CDG-IId 0.473105859383276 -0.748436111337653 9 4 0.0106951871657754 374 978 124583,51727,7360,4831 CANT1,CMPK1,UGP2,NME2 SMP00479 Plasmalogen Synthesis 0.494336832697281 -0.704538146581306 4 2 0.0053475935828877 374 978 8443,10554 GNPAT,AGPAT1 SMP00322 Vasopressin Regulation of Water Homeostasis 0.541623219098683 -0.613184686998213 7 3 0.00802139037433155 374 978 2778,2782,5567 GNAS,GNB1,PRKACB SMP00442 Etoposide Action Pathway 0.566878061479642 -0.567611057501711 18 7 0.018716577540107 374 978 7153,5743,5479,23753,10130,10961,9601 TOP2A,PTGS2,PPIB,SDF2L1,PDIA6,ERP29,PDIA4 SMP00649 Lamivudine Metabolism Pathway 0.566878061479642 -0.567611057501711 18 7 0.018716577540107 374 978 30833,51727,5833,4830,1633,5130,9429 NT5C,CMPK1,PCYT2,NME1,DCK,PCYT1A,ABCG2 SMP00601 Etoposide Metabolism Pathway 0.566878061479642 -0.567611057501711 18 7 0.018716577540107 374 978 7153,5743,5479,23753,10130,10961,9601 TOP2A,PTGS2,PPIB,SDF2L1,PDIA6,ERP29,PDIA4 SMP00482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids 0.573299279417933 -0.556347395970852 10 4 0.0106951871657754 374 978 2180,1892,10449,3032 ACSL1,ECHS1,ACAA2,HADHB SMP00338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin 0.573299279417933 -0.556347395970852 10 4 0.0106951871657754 374 978 2778,2782,5499,5567 GNAS,GNB1,PPP1CA,PRKACB SMP00525 Fabry disease 0.588406566300037 -0.530337130731744 21 8 0.0213903743315508 374 978 2531,7357,10825,2629,55331,2717,9517,56848 KDSR,UGCG,NEU3,GBA,ACER3,GLA,SPTLC2,SPHK2 SMP00526 Krabbe disease 0.588406566300037 -0.530337130731744 21 8 0.0213903743315508 374 978 2531,7357,10825,2629,55331,2717,9517,56848 KDSR,UGCG,NEU3,GBA,ACER3,GLA,SPTLC2,SPHK2 SMP00349 Gaucher Disease 0.588406566300037 -0.530337130731744 21 8 0.0213903743315508 374 978 2531,7357,10825,2629,55331,2717,9517,56848 KDSR,UGCG,NEU3,GBA,ACER3,GLA,SPTLC2,SPHK2 SMP00034 Sphingolipid Metabolism 0.588406566300037 -0.530337130731744 21 8 0.0213903743315508 374 978 2531,7357,10825,2629,55331,2717,56848,9517 KDSR,UGCG,NEU3,GBA,ACER3,GLA,SPHK2,SPTLC2 SMP00347 Metachromatic Leukodystrophy (MLD) 0.588406566300037 -0.530337130731744 21 8 0.0213903743315508 374 978 2531,7357,10825,2629,55331,2717,9517,56848 KDSR,UGCG,NEU3,GBA,ACER3,GLA,SPTLC2,SPHK2 SMP00348 Globoid Cell Leukodystrophy 0.588406566300037 -0.530337130731744 21 8 0.0213903743315508 374 978 2531,7357,10825,2629,55331,2717,9517,56848 KDSR,UGCG,NEU3,GBA,ACER3,GLA,SPTLC2,SPHK2 SMP00037 Lysine Degradation 0.597850381368182 -0.514414754717309 13 5 0.0133689839572193 374 978 38,51166,2639,1743,1892 ACAT1,AADAT,GCDH,DLST,ECHS1 SMP00186 Glutaric Aciduria Type I 0.597850381368182 -0.514414754717309 13 5 0.0133689839572193 374 978 38,51166,2639,1743,1892 ACAT1,AADAT,GCDH,DLST,ECHS1 SMP00528 Hyperlysinemia II or Saccharopinuria 0.597850381368182 -0.514414754717309 13 5 0.0133689839572193 374 978 38,51166,2639,1743,1892 ACAT1,AADAT,GCDH,DLST,ECHS1 SMP00527 Hyperlysinemia I- Familial 0.597850381368182 -0.514414754717309 13 5 0.0133689839572193 374 978 38,51166,2639,1743,1892 ACAT1,AADAT,GCDH,DLST,ECHS1 SMP00239 Saccharopinuria/Hyperlysinemia II 0.597850381368182 -0.514414754717309 13 5 0.0133689839572193 374 978 38,51166,2639,1743,1892 ACAT1,AADAT,GCDH,DLST,ECHS1 SMP00719 2-aminoadipic 2-oxoadipic aciduria 0.597850381368182 -0.514414754717309 13 5 0.0133689839572193 374 978 38,51166,2639,1743,1892 ACAT1,AADAT,GCDH,DLST,ECHS1 SMP00571 Pyridoxine dependency with seizures 0.597850381368182 -0.514414754717309 13 5 0.0133689839572193 374 978 38,51166,2639,1743,1892 ACAT1,AADAT,GCDH,DLST,ECHS1 SMP00555 Glycogenosis- Type VI. Hers disease 0.61824897850442 -0.480864024819065 16 6 0.0160427807486631 374 978 283209,2632,5236,7360,178,7358 PGM2L1,GBE1,PGM1,UGP2,AGL,UGDH SMP00058 Starch and Sucrose Metabolism 0.61824897850442 -0.480864024819065 16 6 0.0160427807486631 374 978 283209,2632,5236,7360,178,7358 PGM2L1,GBE1,PGM1,UGP2,AGL,UGDH SMP00557 Sucrase-isomaltase deficiency 0.61824897850442 -0.480864024819065 16 6 0.0160427807486631 374 978 283209,2632,5236,7360,178,7358 PGM2L1,GBE1,PGM1,UGP2,AGL,UGDH SMP00556 Mucopolysaccharidosis VI. Sly syndrome 0.61824897850442 -0.480864024819065 16 6 0.0160427807486631 374 978 283209,2632,5236,7360,178,7358 PGM2L1,GBE1,PGM1,UGP2,AGL,UGDH SMP00552 Glycogen synthetase deficiency 0.61824897850442 -0.480864024819065 16 6 0.0160427807486631 374 978 283209,2632,5236,7360,178,7358 PGM2L1,GBE1,PGM1,UGP2,AGL,UGDH SMP00455 Homocysteine Degradation 0.6188281392187 -0.479927687466613 2 1 0.00267379679144385 374 978 1491 CTH SMP00515 Homocystinuria- cystathionine beta-synthase deficiency 0.6188281392187 -0.479927687466613 2 1 0.00267379679144385 374 978 1491 CTH SMP00514 Gamma-cystathionase deficiency (CTH) 0.6188281392187 -0.479927687466613 2 1 0.00267379679144385 374 978 1491 CTH SMP00070 Riboflavin Metabolism 0.632484755303852 -0.458099160957326 5 2 0.0053475935828877 374 978 52,80308 ACP1,FLAD1 SMP00468 Degradation of Superoxides 0.632484755303852 -0.458099160957326 5 2 0.0053475935828877 374 978 847,6648 CAT,SOD2 SMP00469 Capecitabine Action Pathway 0.632484755303852 -0.458099160957326 5 2 0.0053475935828877 374 978 7298,1890 TYMS,TYMP SMP00607 Capecitabine Metabolism Pathway 0.632484755303852 -0.458099160957326 5 2 0.0053475935828877 374 978 7298,1890 TYMS,TYMP SMP00503 Hypophosphatasia 0.632484755303852 -0.458099160957326 5 2 0.0053475935828877 374 978 55163,8566 PNPO,PDXK SMP00017 Vitamin B6 Metabolism 0.632484755303852 -0.458099160957326 5 2 0.0053475935828877 374 978 55163,8566 PNPO,PDXK SMP00569 Succinyl CoA: 3-ketoacid CoA transferase deficiency 0.632484755303852 -0.458099160957326 5 2 0.0053475935828877 374 978 38,3155 ACAT1,HMGCL SMP00071 Ketone Body Metabolism 0.632484755303852 -0.458099160957326 5 2 0.0053475935828877 374 978 38,3155 ACAT1,HMGCL SMP00465 Carnitine Synthesis 0.632484755303852 -0.458099160957326 5 2 0.0053475935828877 374 978 223,55217 ALDH9A1,TMLHE SMP00481 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids 0.647566639278249 -0.434533572899872 8 3 0.00802139037433155 374 978 1892,10449,3032 ECHS1,ACAA2,HADHB SMP00073 Butyrate Metabolism 0.647566639278249 -0.434533572899872 8 3 0.00802139037433155 374 978 38,3155,1892 ACAT1,HMGCL,ECHS1 SMP00354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin 0.647566639278249 -0.434533572899872 8 3 0.00802139037433155 374 978 2778,2782,5567 GNAS,GNB1,PRKACB SMP00123 Betaine Metabolism 0.647566639278249 -0.434533572899872 8 3 0.00802139037433155 374 978 55349,10400,4144 CHDH,PEMT,MAT2A SMP00635 Valproic Acid Metabolism Pathway 0.661722634170954 -0.412908792457323 11 4 0.0106951871657754 374 978 36,1962,3028,3032 ACADSB,EHHADH,HSD17B10,HADHB SMP00029 Selenoamino Acid Metabolism 0.661722634170954 -0.412908792457323 11 4 0.0106951871657754 374 978 4144,9061,51540,1491 MAT2A,PAPSS1,SCLY,CTH SMP00648 Sorafenib Metabolism Pathway 0.674795874039012 -0.393345042675472 14 5 0.0133689839572193 374 978 5479,23753,10130,10961,9601 PPIB,SDF2L1,PDIA6,ERP29,PDIA4 SMP00363 Ornithine Aminotransferase Deficiency (OAT Deficiency) 0.698149168384065 -0.359322490765501 20 7 0.018716577540107 374 978 8659,5625,10166,1373,1152,4942,435 ALDH4A1,PRODH,SLC25A15,CPS1,CKB,OAT,ASL SMP00506 Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome] 0.698149168384065 -0.359322490765501 20 7 0.018716577540107 374 978 8659,5625,10166,1373,1152,4942,435 ALDH4A1,PRODH,SLC25A15,CPS1,CKB,OAT,ASL SMP00507 L-arginine:glycine amidinotransferase deficiency 0.698149168384065 -0.359322490765501 20 7 0.018716577540107 374 978 8659,5625,10166,1373,1152,4942,435 ALDH4A1,PRODH,SLC25A15,CPS1,CKB,OAT,ASL SMP00505 Hyperornithinemia with gyrate atrophy (HOGA) 0.698149168384065 -0.359322490765501 20 7 0.018716577540107 374 978 8659,5625,10166,1373,1152,4942,435 ALDH4A1,PRODH,SLC25A15,CPS1,CKB,OAT,ASL SMP00362 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) 0.698149168384065 -0.359322490765501 20 7 0.018716577540107 374 978 8659,5625,1373,1152,10166,4942,435 ALDH4A1,PRODH,CPS1,CKB,SLC25A15,OAT,ASL SMP00504 Creatine deficiency- guanidinoacetate methyltransferase deficiency 0.698149168384065 -0.359322490765501 20 7 0.018716577540107 374 978 8659,5625,1373,1152,10166,4942,435 ALDH4A1,PRODH,CPS1,CKB,SLC25A15,OAT,ASL SMP00207 Prolidase Deficiency (PD) 0.698149168384065 -0.359322490765501 20 7 0.018716577540107 374 978 8659,5625,10166,1373,1152,4942,435 ALDH4A1,PRODH,SLC25A15,CPS1,CKB,OAT,ASL SMP00360 Hyperprolinemia Type II 0.698149168384065 -0.359322490765501 20 7 0.018716577540107 374 978 8659,5625,10166,1373,1152,4942,435 ALDH4A1,PRODH,SLC25A15,CPS1,CKB,OAT,ASL SMP00188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) 0.698149168384065 -0.359322490765501 20 7 0.018716577540107 374 978 8659,5625,10166,1373,1152,4942,435 ALDH4A1,PRODH,SLC25A15,CPS1,CKB,OAT,ASL SMP00208 Prolinemia Type II 0.698149168384065 -0.359322490765501 20 7 0.018716577540107 374 978 8659,5625,10166,1373,1152,4942,435 ALDH4A1,PRODH,SLC25A15,CPS1,CKB,OAT,ASL SMP00361 Hyperprolinemia Type I 0.698149168384065 -0.359322490765501 20 7 0.018716577540107 374 978 8659,5625,10166,1373,1152,4942,435 ALDH4A1,PRODH,SLC25A15,CPS1,CKB,OAT,ASL SMP00020 Arginine and Proline Metabolism 0.698149168384065 -0.359322490765501 20 7 0.018716577540107 374 978 8659,5625,10166,1373,1152,4942,435 ALDH4A1,PRODH,SLC25A15,CPS1,CKB,OAT,ASL SMP00004 Glycine and Serine Metabolism 0.718566705786534 -0.330496737429332 26 9 0.0240641711229947 374 978 2617,29968,211,63826,6472,5723,132158,2731,1491 GARS,PSAT1,ALAS1,SRR,SHMT2,PSPH,GLYCTK,GLDC,CTH SMP00484 Dimethylglycine Dehydrogenase Deficiency 0.718566705786534 -0.330496737429332 26 9 0.0240641711229947 374 978 2617,29968,211,63826,6472,5723,132158,2731,1491 GARS,PSAT1,ALAS1,SRR,SHMT2,PSPH,GLYCTK,GLDC,CTH SMP00244 Sarcosinemia 0.718566705786534 -0.330496737429332 26 9 0.0240641711229947 374 978 2617,29968,211,63826,6472,5723,132158,2731,1491 GARS,PSAT1,ALAS1,SRR,SHMT2,PSPH,GLYCTK,GLDC,CTH SMP00242 Dimethylglycine Dehydrogenase Deficiency 0.718566705786534 -0.330496737429332 26 9 0.0240641711229947 374 978 2617,29968,211,63826,6472,5723,132158,2731,1491 GARS,PSAT1,ALAS1,SRR,SHMT2,PSPH,GLYCTK,GLDC,CTH SMP00223 Non Ketotic Hyperglycinemia 0.718566705786534 -0.330496737429332 26 9 0.0240641711229947 374 978 2617,29968,211,63826,6472,5723,132158,2731,1491 GARS,PSAT1,ALAS1,SRR,SHMT2,PSPH,GLYCTK,GLDC,CTH SMP00179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) 0.718566705786534 -0.330496737429332 26 9 0.0240641711229947 374 978 2617,29968,211,63826,6472,5723,132158,2731,1491 GARS,PSAT1,ALAS1,SRR,SHMT2,PSPH,GLYCTK,GLDC,CTH SMP00721 3-Phosphoglycerate dehydrogenase deficiency 0.718566705786534 -0.330496737429332 26 9 0.0240641711229947 374 978 2617,29968,211,63826,6472,5723,132158,2731,1491 GARS,PSAT1,ALAS1,SRR,SHMT2,PSPH,GLYCTK,GLDC,CTH SMP00485 Hyperglycinemia- non-ketotic 0.718566705786534 -0.330496737429332 26 9 0.0240641711229947 374 978 2617,29968,63826,211,6472,132158,5723,1491,2731 GARS,PSAT1,SRR,ALAS1,SHMT2,GLYCTK,PSPH,CTH,GLDC SMP00351 GABA-Transaminase Deficiency 0.73479702922761 -0.308160968616663 9 3 0.00802139037433155 374 978 1806,4329,2571 DPYD,ALDH6A1,GAD1 SMP00492 Ureidopropionase deficiency 0.73479702922761 -0.308160968616663 9 3 0.00802139037433155 374 978 1806,4329,2571 DPYD,ALDH6A1,GAD1 SMP00493 Carnosinuria- carnosinemia 0.73479702922761 -0.308160968616663 9 3 0.00802139037433155 374 978 1806,4329,2571 DPYD,ALDH6A1,GAD1 SMP00007 Beta-Alanine Metabolism 0.73479702922761 -0.308160968616663 9 3 0.00802139037433155 374 978 1806,4329,2571 DPYD,ALDH6A1,GAD1 SMP00027 Pantothenate and CoA Biosynthesis 0.739148297810182 -0.302256704539426 6 2 0.0053475935828877 374 978 79717,53354 PPCS,PANK1 SMP00622 Morphine Metabolism Pathway 0.741285080881214 -0.299370003137507 15 5 0.0133689839572193 374 978 5479,23753,10130,10961,9601 PPIB,SDF2L1,PDIA6,ERP29,PDIA4 SMP00420 Bevacizumab Action Pathway 0.764891946529339 -0.268020701498685 3 1 0.00267379679144385 374 978 7422 VEGFA SMP00564 Multiple carboxylase deficiency- neonatal or early onset form 0.764891946529339 -0.268020701498685 3 1 0.00267379679144385 374 978 686 BTD SMP00464 Vitamin K Metabolism 0.764891946529339 -0.268020701498685 3 1 0.00267379679144385 374 978 2677 GGCX SMP00459 Pyruvaldehyde Degradation 0.764891946529339 -0.268020701498685 3 1 0.00267379679144385 374 978 197257 LDHD SMP00174 Biotinidase Deficiency 0.764891946529339 -0.268020701498685 3 1 0.00267379679144385 374 978 686 BTD SMP00472 Erlotinib Action Pathway 0.764891946529339 -0.268020701498685 3 1 0.00267379679144385 374 978 9429 ABCG2 SMP00066 Biotin Metabolism 0.764891946529339 -0.268020701498685 3 1 0.00267379679144385 374 978 686 BTD SMP00437 Vincristine Action Pathway 0.804010350576832 -0.218143136034257 10 3 0.00802139037433155 374 978 1026,10928,89845 CDKN1A,RALBP1,ABCC10 SMP00438 Vindesine Action Pathway 0.804010350576832 -0.218143136034257 10 3 0.00802139037433155 374 978 1026,10928,89845 CDKN1A,RALBP1,ABCC10 SMP00078 Chlorothiazide Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00088 Bumetanide Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,360,482,481,9990,6505,4306,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,AQP3,ATP1B2,ATP1B1,SLC12A6,SLC1A1,NR3C2,SLC7A6 SMP00115 Furosemide Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00105 Metolazone Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00197 Lysinuric Protein Intolerance 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00245 Glucose Transporter Defect (SGLT2) 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00090 Bendroflumethiazide Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00100 Hydrochlorothiazide Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00583 Blue diaper syndrome 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,360,482,481,9990,6505,4306,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,AQP3,ATP1B2,ATP1B1,SLC12A6,SLC1A1,NR3C2,SLC7A6 SMP00135 Eplerenone Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00483 Kidney Function 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00081 Methyclothiazide Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00108 Hydroflumethiazide Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00723 Cystinuria 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00134 Spironolactone Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00118 Torsemide Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00189 Hartnup Disorder 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,360,482,481,9990,6505,4306,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,AQP3,ATP1B2,ATP1B1,SLC12A6,SLC1A1,NR3C2,SLC7A6 SMP00133 Amiloride Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00184 Glucose Transporter Defect (SGLT2) 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00097 Ethacrynic Acid Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00091 Quinethazone Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,360,482,481,9990,6505,4306,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,AQP3,ATP1B2,ATP1B1,SLC12A6,SLC1A1,NR3C2,SLC7A6 SMP00585 Lysinuric protein intolerance (LPI) 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00132 Triamterene Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00103 Cyclothiazide Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00110 Indapamide Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,482,360,9990,481,4306,6505,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,ATP1B2,AQP3,SLC12A6,ATP1B1,NR3C2,SLC1A1,SLC7A6 SMP00193 Iminoglycinuria 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,360,482,481,9990,6505,4306,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,AQP3,ATP1B2,ATP1B1,SLC12A6,SLC1A1,NR3C2,SLC7A6 SMP00121 Trichlormethiazide Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,360,482,481,9990,6505,4306,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,AQP3,ATP1B2,ATP1B1,SLC12A6,SLC1A1,NR3C2,SLC7A6 SMP00080 Polythiazide Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,360,482,481,9990,6505,4306,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,AQP3,ATP1B2,ATP1B1,SLC12A6,SLC1A1,NR3C2,SLC7A6 SMP00122 Chlorthalidone Action Pathway 0.814793423189493 -0.204820666348988 34 11 0.0294117647058824 374 978 476,6520,6337,6559,360,482,481,9990,6505,4306,9057 ATP1A1,SLC3A2,SCNN1A,SLC12A3,AQP3,ATP1B2,ATP1B1,SLC12A6,SLC1A1,NR3C2,SLC7A6 SMP00041 Sulfate/Sulfite Metabolism 0.818158329296154 -0.200699404512286 7 2 0.0053475935828877 374 978 50515,6821 CHST11,SUOX SMP00532 Sulfite oxidase deficiency 0.818158329296154 -0.200699404512286 7 2 0.0053475935828877 374 978 50515,6821 CHST11,SUOX SMP00650 Doxorubicin Metabolism Pathway 0.843175685417625 -0.170579937690473 17 5 0.0133689839572193 374 978 4720,10928,374291,9429,10327 NDUFS2,RALBP1,NDUFS7,ABCG2,AKR1A1 SMP00336 Vitamin A Deficiency 0.846719128995098 -0.166386246177279 35 11 0.0294117647058824 374 978 54884,5479,23753,8228,8694,10130,9249,10961,1592,51109,9601 RETSAT,PPIB,SDF2L1,PNPLA4,DGAT1,PDIA6,DHRS3,ERP29,CYP26A1,RDH11,PDIA4 SMP00074 Retinol Metabolism 0.846719128995098 -0.166386246177279 35 11 0.0294117647058824 374 978 54884,5479,23753,8228,8694,10130,9249,10961,1592,51109,9601 RETSAT,PPIB,SDF2L1,PNPLA4,DGAT1,PDIA6,DHRS3,ERP29,CYP26A1,RDH11,PDIA4 SMP00048 Nicotinate and Nicotinamide Metabolism 0.848027212942999 -0.164842552970462 14 4 0.0106951871657754 374 978 54981,4860,65220,23530 NMRK1,PNP,NADK,NNT SMP00618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway 0.855076984480244 -0.156563773770993 4 1 0.00267379679144385 374 978 6645 SNTB2 SMP00602 Teniposide Metabolism Pathway 0.855076984480244 -0.156563773770993 4 1 0.00267379679144385 374 978 7153 TOP2A SMP00620 Lidocaine (Local Anaesthetic) Metabolism Pathway 0.855076984480244 -0.156563773770993 4 1 0.00267379679144385 374 978 6324 SCN1B SMP00443 Teniposide Action Pathway 0.855076984480244 -0.156563773770993 4 1 0.00267379679144385 374 978 7153 TOP2A SMP00065 Ubiquinone Biosynthesis 0.855076984480244 -0.156563773770993 4 1 0.00267379679144385 374 978 51805 COQ3 SMP00436 Vinblastine Action Pathway 0.857368244230543 -0.153887762790671 11 3 0.00802139037433155 374 978 1026,10928,89845 CDKN1A,RALBP1,ABCC10 SMP00439 Vinorelbine Action Pathway 0.857368244230543 -0.153887762790671 11 3 0.00802139037433155 374 978 1026,10928,89845 CDKN1A,RALBP1,ABCC10 SMP00433 Irinotecan Action Pathway 0.876182683180613 -0.132180667344076 21 6 0.0160427807486631 374 978 5479,23753,10130,10961,9601,9429 PPIB,SDF2L1,PDIA6,ERP29,PDIA4,ABCG2 SMP00600 Irinotecan Metabolism Pathway 0.876182683180613 -0.132180667344076 21 6 0.0160427807486631 374 978 5479,23753,10130,10961,9601,9429 PPIB,SDF2L1,PDIA6,ERP29,PDIA4,ABCG2 SMP00458 Lactose Intolerance 0.897562930062476 -0.108072044016534 12 3 0.00802139037433155 374 978 482,481,476 ATP1B2,ATP1B1,ATP1A1 SMP00457 Lactose Degradation 0.897562930062476 -0.108072044016534 12 3 0.00802139037433155 374 978 482,476,481 ATP1B2,ATP1A1,ATP1B1 SMP00590 Ibuprofen Metabolism Pathway 0.904608444897421 -0.100253086477414 22 6 0.0160427807486631 374 978 5479,5743,23753,10130,10961,9601 PPIB,PTGS2,SDF2L1,PDIA6,ERP29,PDIA4 SMP00018 Alpha Linolenic Acid and Linoleic Acid Metabolism 0.91072504177926 -0.0935142474994194 5 1 0.00267379679144385 374 978 60481 ELOVL5 SMP00467 Trehalose Degradation 0.927272045679397 -0.075508287560046 13 3 0.00802139037433155 374 978 482,476,481 ATP1B2,ATP1A1,ATP1B1 SMP00317 Familial Hypercholanemia (FHCA) 0.939348824949353 -0.0625683831884888 17 4 0.0106951871657754 374 978 6342,3295,51302,10858 SCP2,HSD17B4,CYP39A1,CYP46A1 SMP00316 Zellweger Syndrome 0.939348824949353 -0.0625683831884888 17 4 0.0106951871657754 374 978 6342,3295,51302,10858 SCP2,HSD17B4,CYP39A1,CYP46A1 SMP00315 Cerebrotendinous Xanthomatosis (CTX) 0.939348824949353 -0.0625683831884888 17 4 0.0106951871657754 374 978 6342,3295,51302,10858 SCP2,HSD17B4,CYP39A1,CYP46A1 SMP00314 Congenital Bile Acid Synthesis Defect Type II 0.939348824949353 -0.0625683831884888 17 4 0.0106951871657754 374 978 6342,3295,51302,10858 SCP2,HSD17B4,CYP39A1,CYP46A1 SMP00035 Bile Acid Biosynthesis 0.939348824949353 -0.0625683831884888 17 4 0.0106951871657754 374 978 6342,3295,51302,10858 SCP2,HSD17B4,CYP39A1,CYP46A1 SMP00318 Congenital Bile Acid Synthesis Defect Type III 0.939348824949353 -0.0625683831884888 17 4 0.0106951871657754 374 978 6342,3295,51302,10858 SCP2,HSD17B4,CYP39A1,CYP46A1 SMP00720 27-Hydroxylase Deficiency 0.939348824949353 -0.0625683831884888 17 4 0.0106951871657754 374 978 6342,3295,51302,10858 SCP2,HSD17B4,CYP39A1,CYP46A1 SMP00640 Acetaminophen Metabolism Pathway 0.955240834907702 -0.045791787144806 28 7 0.018716577540107 374 978 2952,5479,23753,10130,10961,9601,9429 GSTT1,PPIB,SDF2L1,PDIA6,ERP29,PDIA4,ABCG2 SMP00370 Tyrosinemia Type 3 (TYRO3) 0.961852817344519 -0.0388938365449614 11 2 0.0053475935828877 374 978 2954,2193 GSTZ1,FARSA SMP00008 Phenylalanine and Tyrosine Metabolism 0.961852817344519 -0.0388938365449614 11 2 0.0053475935828877 374 978 2954,2193 GSTZ1,FARSA SMP00206 Phenylketonuria 0.961852817344519 -0.0388938365449614 11 2 0.0053475935828877 374 978 2954,2193 GSTZ1,FARSA SMP00369 Tyrosinemia Type 2 (or Richner-Hanhart syndrome) 0.961852817344519 -0.0388938365449614 11 2 0.0053475935828877 374 978 2954,2193 GSTZ1,FARSA SMP00449 Ethanol Degradation 0.966187400793638 -0.0343974669037568 7 1 0.00267379679144385 374 978 847 CAT SMP00634 Carbamazepine Metabolism Pathway 0.966187400793638 -0.0343974669037568 7 1 0.00267379679144385 374 978 2052 EPHX1 SMP00434 Paclitaxel Action Pathway 0.966187400793638 -0.0343974669037568 7 1 0.00267379679144385 374 978 9429 ABCG2 SMP00435 Docetaxel Action Pathway 0.966187400793638 -0.0343974669037568 7 1 0.00267379679144385 374 978 9429 ABCG2 SMP00063 Tryptophan Metabolism 0.968710082717427 -0.0317899041003767 19 4 0.0106951871657754 374 978 847,51166,125061,8942 CAT,AADAT,AFMID,KYNU SMP00652 Mycophenolic Acid Metabolism Pathway 0.975396597559228 -0.0249111239640339 16 3 0.00802139037433155 374 978 3614,3615,9429 IMPDH1,IMPDH2,ABCG2 SMP00644 Celecoxib Metabolism Pathway 0.979210997199271 -0.0210081364872317 8 1 0.00267379679144385 374 978 5743 PTGS2 SMP00642 Nevirapine Metabolism Pathway 0.979210997199271 -0.0210081364872317 8 1 0.00267379679144385 374 978 89845 ABCC10 SMP00716 Thyroid hormone synthesis 0.987226550864438 -0.0128557310706813 9 1 0.00267379679144385 374 978 1535 CYBA SMP00406 Morphine Action Pathway 0.990203497395741 -0.00984480405161845 40 9 0.0240641711229947 374 978 5479,476,6324,482,23753,481,10961,10130,9601 PPIB,ATP1A1,SCN1B,ATP1B2,SDF2L1,ATP1B1,ERP29,PDIA6,PDIA4 SMP00306 Pindolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00323 Quinidine Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00660 Sotalol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,8913,3759,3775,6645,3708,482,481,3767,7168,5566,144245 ATP1A1,TPM2,ATP2A2,CACNA1G,KCNJ2,KCNK1,SNTB2,ITPR1,ATP1B2,ATP1B1,KCNJ11,TPM1,PRKACA,ALG10B SMP00379 Nifedipine Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,8913,3759,3775,6645,3708,482,481,3767,7168,5566,144245 ATP1A1,TPM2,ATP2A2,CACNA1G,KCNJ2,KCNK1,SNTB2,ITPR1,ATP1B2,ATP1B1,KCNJ11,TPM1,PRKACA,ALG10B SMP00325 Disopyramide Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00669 Practolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,8913,3759,3775,6645,3708,482,481,3767,7168,5566,144245 ATP1A1,TPM2,ATP2A2,CACNA1G,KCNJ2,KCNK1,SNTB2,ITPR1,ATP1B2,ATP1B1,KCNJ11,TPM1,PRKACA,ALG10B SMP00667 Metipranolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00380 Nimodipine Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00381 Nisoldipine Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00659 Timolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00661 Epinephrine Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00324 Procainamide (Antiarrhythmic) Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00366 Nebivolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,8913,3759,3775,6645,3708,482,481,3767,7168,5566,144245 ATP1A1,TPM2,ATP2A2,CACNA1G,KCNJ2,KCNK1,SNTB2,ITPR1,ATP1B2,ATP1B1,KCNJ11,TPM1,PRKACA,ALG10B SMP00377 Felodipine Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,8913,3759,3775,6645,3708,482,481,3767,7168,5566,144245 ATP1A1,TPM2,ATP2A2,CACNA1G,KCNJ2,KCNK1,SNTB2,ITPR1,ATP1B2,ATP1B1,KCNJ11,TPM1,PRKACA,ALG10B SMP00296 Acebutolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00305 Penbutolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00663 Isoprenaline Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,8913,3759,3775,6645,3708,482,481,3767,7168,5566,144245 ATP1A1,TPM2,ATP2A2,CACNA1G,KCNJ2,KCNK1,SNTB2,ITPR1,ATP1B2,ATP1B1,KCNJ11,TPM1,PRKACA,ALG10B SMP00658 Carteolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00657 Bopindolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00664 Arbutamine Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00588 Muscle/Heart Contraction 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00298 Atenolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00304 Oxprenolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,8913,3759,3775,6645,3708,482,481,3767,7168,5566,144245 ATP1A1,TPM2,ATP2A2,CACNA1G,KCNJ2,KCNK1,SNTB2,ITPR1,ATP1B2,ATP1B1,KCNJ11,TPM1,PRKACA,ALG10B SMP00332 Ibutilide Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00665 Amiodarone Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00378 Isradipine Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00670 Bupranolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,8913,3759,3775,6645,3708,482,481,3767,7168,5566,144245 ATP1A1,TPM2,ATP2A2,CACNA1G,KCNJ2,KCNK1,SNTB2,ITPR1,ATP1B2,ATP1B1,KCNJ11,TPM1,PRKACA,ALG10B SMP00303 Nadolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00297 Alprenolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00331 Flecainide Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00359 Diltiazem Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00375 Verapamil Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00382 Nitrendipine Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00662 Dobutamine Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00329 Mexiletine Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,8913,3759,3775,6645,3708,482,481,3767,7168,5566,144245 ATP1A1,TPM2,ATP2A2,CACNA1G,KCNJ2,KCNK1,SNTB2,ITPR1,ATP1B2,ATP1B1,KCNJ11,TPM1,PRKACA,ALG10B SMP00302 Metoprolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,3759,8913,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,KCNJ2,CACNA1G,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00300 Bisoprolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,8913,3759,3775,6645,3708,482,481,3767,7168,5566,144245 ATP1A1,TPM2,ATP2A2,CACNA1G,KCNJ2,KCNK1,SNTB2,ITPR1,ATP1B2,ATP1B1,KCNJ11,TPM1,PRKACA,ALG10B SMP00376 Amlodipine Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00301 Esmolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00299 Betaxolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00330 Tocainide Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00307 Propranolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,8913,3759,3775,6645,3708,482,481,3767,7168,5566,144245 ATP1A1,TPM2,ATP2A2,CACNA1G,KCNJ2,KCNK1,SNTB2,ITPR1,ATP1B2,ATP1B1,KCNJ11,TPM1,PRKACA,ALG10B SMP00326 Fosphenytoin (Antiarrhythmic) Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00666 Levobunolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00668 Bevantolol Action Pathway 0.991648685337281 -0.00838638226790511 57 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00494 Tyrosinemia- transient 0.992875406654654 -0.00715009445606403 15 2 0.0053475935828877 374 978 4282,2954 MIF,GSTZ1 SMP00327 Phenytoin (Antiarrhythmic) Action Pathway 0.993524668533629 -0.00649638737036118 77 20 0.053475935828877 374 978 5479,7169,8913,3759,6645,23753,481,10961,5566,9601,476,488,3775,3708,482,3767,7168,10130,144245,2052 PPIB,TPM2,CACNA1G,KCNJ2,SNTB2,SDF2L1,ATP1B1,ERP29,PRKACA,PDIA4,ATP1A1,ATP2A2,KCNK1,ITPR1,ATP1B2,KCNJ11,TPM1,PDIA6,ALG10B,EPHX1 SMP00368 Labetalol Action Pathway 0.993553212673898 -0.00646765760537208 58 14 0.0374331550802139 374 978 476,7169,488,3775,8913,3759,6645,3708,482,3767,481,7168,5566,144245 ATP1A1,TPM2,ATP2A2,KCNK1,CACNA1G,KCNJ2,SNTB2,ITPR1,ATP1B2,KCNJ11,ATP1B1,TPM1,PRKACA,ALG10B SMP00367 Carvedilol Action Pathway 0.993553212673898 -0.00646765760537208 58 14 0.0374331550802139 374 978 476,7169,488,8913,3759,3775,6645,3708,482,481,3767,7168,5566,144245 ATP1A1,TPM2,ATP2A2,CACNA1G,KCNJ2,KCNK1,SNTB2,ITPR1,ATP1B2,ATP1B1,KCNJ11,TPM1,PRKACA,ALG10B SMP00328 Lidocaine (Antiarrhythmic) Action Pathway 0.995047392574463 -0.00496491222974784 59 14 0.0374331550802139 374 978 476,7169,488,8913,3759,3775,6645,3708,482,481,3767,7168,5566,144245 ATP1A1,TPM2,ATP2A2,CACNA1G,KCNJ2,KCNK1,SNTB2,ITPR1,ATP1B2,ATP1B1,KCNJ11,TPM1,PRKACA,ALG10B SMP00706 Tenoxicam Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00693 Antrafenine Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00102 Bromfenac Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00699 Lumiracoxib Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00098 Ketorolac Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00106 Meloxicam Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00707 Salsalate Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00085 Ketoprofen Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00692 Antipyrine Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00353 Leukotriene C4 Synthesis Deficiency 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00700 Lornoxicam Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00701 Phenylbutazone Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00094 Sulindac Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00114 Nabumetone Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00109 Mefenamic Acid Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00113 Oxaprozin Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00702 Nepafenac Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00698 Magnesium salicylate Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00289 Diflunisal Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00708 Salicylate-sodium Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00077 Piroxicam Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00083 Acetylsalicylic Acid Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00710 Acetaminophen Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00697 Flurbiprofen Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00084 Etodolac Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00075 Arachidonic Acid Metabolism 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00696 Fenoprofen Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00703 Trisalicylate-choline Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00709 Salicylic Acid Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00093 Diclofenac Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00695 Etoricoxib Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00101 Suprofen Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00704 Tolmetin Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00694 Carprofen Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00705 Tiaprofenic Acid Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00087 Rofecoxib Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00116 Valdecoxib Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00120 Naproxen Action Pathway 0.995061402158897 -0.00495083301511287 28 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00566 17-alpha-hydroxylase deficiency (CYP17) 0.995187037720779 -0.00482458188029773 11 1 0.00267379679144385 374 978 3291 HSD11B2 SMP00371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH 0.995187037720779 -0.00482458188029773 11 1 0.00267379679144385 374 978 3291 HSD11B2 SMP00575 11-beta-hydroxylase deficiency (CYP11B1) 0.995187037720779 -0.00482458188029773 11 1 0.00267379679144385 374 978 3291 HSD11B2 SMP00717 Apparent mineralocorticoid excess syndrome 0.995187037720779 -0.00482458188029773 11 1 0.00267379679144385 374 978 3291 HSD11B2 SMP00372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia due to 17 Alpha-hydroxylase Deficiency 0.995187037720779 -0.00482458188029773 11 1 0.00267379679144385 374 978 3291 HSD11B2 SMP00576 21-hydroxylase deficiency (CYP21) 0.995187037720779 -0.00482458188029773 11 1 0.00267379679144385 374 978 3291 HSD11B2 SMP00577 Corticosterone methyl oxidase I deficiency (CMO I) 0.995187037720779 -0.00482458188029773 11 1 0.00267379679144385 374 978 3291 HSD11B2 SMP00578 Corticosterone methyl oxidase II deficiency - CMO II 0.995187037720779 -0.00482458188029773 11 1 0.00267379679144385 374 978 3291 HSD11B2 SMP00718 3-Beta-Hydroxysteroid Dehydrogenase Deficiency 0.995187037720779 -0.00482458188029773 11 1 0.00267379679144385 374 978 3291 HSD11B2 SMP00373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency 0.995187037720779 -0.00482458188029773 11 1 0.00267379679144385 374 978 3291 HSD11B2 SMP00130 Steroidogenesis 0.995187037720779 -0.00482458188029773 11 1 0.00267379679144385 374 978 3291 HSD11B2 SMP00104 Indomethacin Action Pathway 0.996540416558793 -0.00346558163817087 29 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00086 Ibuprofen Action Pathway 0.996610737449764 -0.00339501911123171 47 10 0.0267379679144385 374 978 5743,5479,6916,23753,113612,10961,10130,2876,9536,9601 PTGS2,PPIB,TBXAS1,SDF2L1,CYP2U1,ERP29,PDIA6,GPX1,PTGES,PDIA4 SMP00218 Tyrosinemia Type I 0.997005880602674 -0.00299861074012737 17 2 0.0053475935828877 374 978 4282,2954 MIF,GSTZ1 SMP00498 Dopamine beta-hydroxylase deficiency 0.997005880602674 -0.00299861074012737 17 2 0.0053475935828877 374 978 4282,2954 MIF,GSTZ1 SMP00533 Monoamine oxidase-a deficiency (MAO-A) 0.997005880602674 -0.00299861074012737 17 2 0.0053475935828877 374 978 4282,2954 MIF,GSTZ1 SMP00190 Hawkinsinuria 0.997005880602674 -0.00299861074012737 17 2 0.0053475935828877 374 978 4282,2954 MIF,GSTZ1 SMP00006 Tyrosine Metabolism 0.997005880602674 -0.00299861074012737 17 2 0.0053475935828877 374 978 4282,2954 MIF,GSTZ1 SMP00169 Alkaptonuria 0.997005880602674 -0.00299861074012737 17 2 0.0053475935828877 374 978 4282,2954 MIF,GSTZ1 SMP00674 Anileridine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00411 Hydrocodone Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00689 Dihydromorphine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00687 Naltrexone Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00675 Diphenoxylate Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00417 Sufentanil Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00686 Pentazocine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00404 Ropivacaine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00425 Escitalopram Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00679 3-Methylthiofentanyl Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00681 Ethylmorphine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00684 Buprenorphine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00672 Propoxyphene Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00690 Ketobemidone Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00392 Benzocaine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00410 Hydromorphone Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00399 Mepivacaine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00678 Methadyl Acetate Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00416 Remifentanil Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00671 Tramadol Action Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00393 Bupivacaine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00396 Dibucaine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00415 Fentanyl Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00673 Levorphanol Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00401 Prilocaine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00685 Alvimopan Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00400 Oxybuprocaine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00394 Chloroprocaine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00414 Carfentanil Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00397 Levobupivacaine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00676 Dezocine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00413 Alfentanil Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00395 Cocaine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00412 Oxymorphone Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00688 Naloxone Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00403 Proparacaine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00677 Levomethadyl Acetate Action Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00683 Levallorphan Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00402 Procaine Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00680 Dimethylthiambutene Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00409 Oxycodone Action Pathway 0.997527065021296 -0.00247599773277858 26 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00691 Nalbuphine Action Pathway 0.998316375931934 -0.00168504295587324 27 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00423 Desipramine Action Pathway 0.998316375931934 -0.00168504295587324 27 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00398 Lidocaine (Local Anaesthetic) Action Pathway 0.998858871562382 -0.00114178002041377 28 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00282 Streptokinase Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00268 Warfarin Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00276 Argatroban Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00288 Aprotinin Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00279 Ximelagatran Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00281 Anistreplase Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00656 Dicoumarol Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00283 Tenecteplase Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00269 Acenocoumarol Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00280 Alteplase Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00277 Bivalirudin Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00271 Phenprocoumon Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00044 Histidine Metabolism 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 23438 HARS2 SMP00285 Reteplase Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00191 Histidinemia 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 23438 HARS2 SMP00278 Lepirudin Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00655 Phenindione Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00586 Coagulation 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00284 Urokinase Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00287 Tranexamic Acid Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00270 Dicumarol Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00286 Aminocaproic Acid Action Pathway 0.998892240669289 -0.00110837334957654 14 1 0.00267379679144385 374 978 2677 GGCX SMP00429 Disulfiram Action Pathway 0.99896670632848 -0.00103382788745859 24 3 0.00802139037433155 374 978 847,4282,2954 CAT,MIF,GSTZ1 SMP00405 Codeine Action Pathway 0.999229824363705 -0.000770472373920005 29 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00407 Heroin Action Pathway 0.999229824363705 -0.000770472373920005 29 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00275 Ardeparin Action Pathway 0.999322014529515 -0.000678215406569305 15 1 0.00267379679144385 374 978 2677 GGCX SMP00273 Fondaparinux Action Pathway 0.999322014529515 -0.000678215406569305 15 1 0.00267379679144385 374 978 2677 GGCX SMP00274 Heparin Action Pathway 0.999322014529515 -0.000678215406569305 15 1 0.00267379679144385 374 978 2677 GGCX SMP00272 Enoxaparin Action Pathway 0.999322014529515 -0.000678215406569305 15 1 0.00267379679144385 374 978 2677 GGCX SMP00096 Celecoxib Action Pathway 0.999457070026101 -0.000543077413746004 34 5 0.0133689839572193 374 978 5743,113612,2876,9536,6916 PTGS2,CYP2U1,GPX1,PTGES,TBXAS1 SMP00422 Imipramine Action Pathway 0.999482262902407 -0.000517871169722604 30 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00426 Fluoxetine Action Pathway 0.999653277288399 -0.000346782833817767 31 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00424 Citalopram Action Pathway 0.99976863912228 -0.000231387645776699 32 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00431 Nicotine Action Pathway 0.99976863912228 -0.000231387645776699 32 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00408 Methadone Action Pathway 0.99976863912228 -0.000231387645776699 32 4 0.0106951871657754 374 978 482,476,481,6324 ATP1B2,ATP1A1,ATP1B1,SCN1B SMP00612 Esomeprazole Metabolism Pathway 0.99999999999184 -8.15986167523874e-12 2 0 0 374 978 SMP00616 Rabeprazole Metabolism Pathway 0.99999999999184 -8.15986167523874e-12 2 0 0 374 978 SMP00613 Omeprazole Metabolism Pathway 0.99999999999184 -8.15986167523874e-12 2 0 0 374 978 SMP00614 Lansoprazole Metabolism Pathway 0.99999999999184 -8.15986167523874e-12 2 0 0 374 978 SMP00615 Pantoprazole Metabolism Pathway 0.99999999999184 -8.15986167523874e-12 2 0 0 374 978 SMP00653 Rosiglitazone Metabolism Pathway 0.999999999997973 -2.02676070371055e-12 3 0 0 374 978 SMP00126 Phenylacetate Metabolism 0.999999999997973 -2.02676070371055e-12 3 0 0 374 978 SMP00619 Felodipine Metabolism Pathway 0.999999999997973 -2.02676070371055e-12 3 0 0 374 978 SMP00626 Desipramine Metabolism Pathway 0.999999999997973 -2.02676070371055e-12 3 0 0 374 978 SMP00631 Prednisone Metabolism Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00265 Abciximab Action Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00476 Trastuzumab Action Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00593 Enalapril Metabolism Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00732 Temocapril Metabolism Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00473 Gefitinib Action Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00261 Ticlopidine Action Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00595 Moexipril Metabolism Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00475 Panitumumab Action Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00474 Cetuximab Action Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00591 Benazepril Metabolism Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00597 Ramipril Metabolism Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00267 Tirofiban Action Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00596 Quinapril Metabolism Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00617 Cimetidine Metabolism Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00421 Vatalanib Action Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00592 Cilazapril Metabolism Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00036 D-Arginine and D-Ornithine Metabolism 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00611 Ticlopidine Metabolism Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00599 Trandolapril Metabolism Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00594 Fosinopril Metabolism Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00598 Spirapril Metabolism Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00440 Prednisone Action Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00638 Levomethadyl Acetate Metabolism Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00266 Eptifibatide Action Pathway 1.00000000000026 2.56072940629792e-13 1 0 0 374 978 SMP00153 Quinapril Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00623 Heroin Metabolism Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00165 Valsartan Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00150 Lisinopril Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00633 Felbamate Metabolism Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00164 Telmisartan Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00651 Artemether Metabolism Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00170 Aromatic L-Aminoacid Decarboxylase Deficiency 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00145 Benazepril Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00733 Temocapril Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00621 Codeine Metabolism Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00152 Perindopril Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00012 Catecholamine Biosynthesis 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00149 Fosinopril Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00163 Olmesartan Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00154 Ramipril Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00497 Tyrosine hydroxylase deficiency 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00148 Enalapril Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00162 Losartan Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00155 Rescinnamine Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00161 Irbesartan Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00639 Clomipramine Metabolism Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00146 Captopril Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00160 Forasartan Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00587 Angiotensin Metabolism 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00159 Eprosartan Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00147 Cilazapril Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00156 Spirapril Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00151 Moexipril Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00158 Candesartan Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00157 Trandolapril Action Pathway 1.00000000000293 2.93494048508869e-12 4 0 0 374 978 SMP00454 Repaglinide Action Pathway 1.00000000000678 6.78242011165064e-12 5 0 0 374 978 SMP00641 Doxepin Metabolism Pathway 1.00000000000678 6.78242011165064e-12 5 0 0 374 978 SMP00453 Nateglinide Action Pathway 1.00000000000678 6.78242011165064e-12 5 0 0 374 978 SMP00460 Glibenclamide Action Pathway 1.00000000000678 6.78242011165064e-12 5 0 0 374 978 SMP00643 Pancreas Function 1.00000000000678 6.78242011165064e-12 5 0 0 374 978 SMP00461 Gliclazide Action Pathway 1.00000000000678 6.78242011165064e-12 5 0 0 374 978 SMP00646 Fluoxetine Metabolism Pathway 1.0000000000104 1.0399193658972e-11 6 0 0 374 978 SMP00636 Venlafaxine Metabolism Pathway 1.0000000000104 1.0399193658972e-11 6 0 0 374 978 SMP00628 Nicotine Metabolism Pathway 1.0000000000104 1.0399193658972e-11 6 0 0 374 978 SMP00625 Imipramine Metabolism Pathway 1.0000000000104 1.0399193658972e-11 6 0 0 374 978 SMP00627 Citalopram Metabolism Pathway 1.0000000000127 1.27034084206751e-11 7 0 0 374 978 SMP00637 Tramadol Metabolism Pathway 1.0000000000127 1.27034084206751e-11 7 0 0 374 978 SMP00605 Ifosfamide Metabolism Pathway 1.00000000001469 1.4693545750781e-11 8 0 0 374 978 SMP00028 Caffeine Metabolism 1.00000000001469 1.4693545750781e-11 8 0 0 374 978 SMP00448 Ifosfamide Action Pathway 1.00000000001469 1.4693545750781e-11 8 0 0 374 978 SMP00228 Pantoprazole Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00232 Cimetidine Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00610 Clopidogrel Metabolism Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00225 Esomeprazole Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00604 Cyclophosphamide Metabolism Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00230 Ranitidine Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00734 Roxatidine acetate Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00226 Omeprazole Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00735 Metiamide Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00260 Clopidogrel Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00736 Betazole Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00589 Gastric Acid Production 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00229 Rabeprazole Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00233 Nizatidine Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00227 Lansoprazole Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00231 Famotidine Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00246 Pirenzepine Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00447 Cyclophosphamide Action Pathway 1.00000000001701 1.70098352991841e-11 9 0 0 374 978 SMP00606 Tamoxifen Metabolism Pathway 1.00000000001948 1.94755374343823e-11 10 0 0 374 978 SMP00471 Tamoxifen Action Pathway 1.00000000001948 1.94755374343823e-11 10 0 0 374 978 SMP00624 Methadone Metabolism Pathway 1.00000000001948 1.94755374343823e-11 10 0 0 374 978 SMP00068 Androgen and Estrogen Metabolism 1.00000000002243 2.24321820308253e-11 12 0 0 374 978 SMP00565 Aromatase deficiency 1.00000000002243 2.24321820308253e-11 12 0 0 374 978 SMP00356 17-Beta Hydroxysteroid Dehydrogenase III Deficiency 1.00000000002243 2.24321820308253e-11 12 0 0 374 978